UNC13B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)6.52534658
2rhodopsin mediated signaling pathway (GO:0016056)6.42865568
3retinal cone cell development (GO:0046549)6.03112852
4retinal rod cell development (GO:0046548)5.69668507
5photoreceptor cell maintenance (GO:0045494)5.62360108
6photoreceptor cell development (GO:0042461)5.51352608
7eye photoreceptor cell development (GO:0042462)5.32077238
8detection of light stimulus involved in visual perception (GO:0050908)5.04278579
9detection of light stimulus involved in sensory perception (GO:0050962)5.04278579
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.67135444
11phototransduction (GO:0007602)4.07140727
12protein-chromophore linkage (GO:0018298)4.00886274
13detection of visible light (GO:0009584)3.99161597
14phototransduction, visible light (GO:0007603)3.97765069
15detection of light stimulus (GO:0009583)3.97698803
16* regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.87695553
17gonadal mesoderm development (GO:0007506)3.86934710
18visual perception (GO:0007601)3.82115401
19sensory perception of light stimulus (GO:0050953)3.79254106
20paraxial mesoderm development (GO:0048339)3.71008877
21regulation of clathrin-mediated endocytosis (GO:2000369)3.69340390
22protein localization to synapse (GO:0035418)3.63961822
23photoreceptor cell differentiation (GO:0046530)3.58554825
24eye photoreceptor cell differentiation (GO:0001754)3.58554825
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.55312450
26synaptic vesicle maturation (GO:0016188)3.52068046
27glutamate secretion (GO:0014047)3.51705599
28response to pheromone (GO:0019236)3.50435129
29cellular potassium ion homeostasis (GO:0030007)3.41984319
30synaptic vesicle exocytosis (GO:0016079)3.36976455
31* regulation of short-term neuronal synaptic plasticity (GO:0048172)3.33703165
32retina development in camera-type eye (GO:0060041)3.19952666
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.19718115
34* synaptic vesicle docking involved in exocytosis (GO:0016081)3.18998572
35GMP metabolic process (GO:0046037)3.17344775
36potassium ion homeostasis (GO:0055075)3.10781876
37vocalization behavior (GO:0071625)3.07828232
38layer formation in cerebral cortex (GO:0021819)3.07649846
39surfactant homeostasis (GO:0043129)3.04317454
40positive regulation of guanylate cyclase activity (GO:0031284)3.04207060
41cellular response to light stimulus (GO:0071482)2.97559020
42chemical homeostasis within a tissue (GO:0048875)2.95672029
43detection of external stimulus (GO:0009581)2.94789123
44cerebellar Purkinje cell differentiation (GO:0021702)2.94420406
45cell communication by electrical coupling (GO:0010644)2.92841335
46embryonic retina morphogenesis in camera-type eye (GO:0060059)2.91681472
47positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.90854929
48sodium ion export (GO:0071436)2.89958544
49detection of abiotic stimulus (GO:0009582)2.88505369
50synaptic vesicle endocytosis (GO:0048488)2.87503505
51negative regulation of cytosolic calcium ion concentration (GO:0051481)2.87392440
52positive regulation of synapse maturation (GO:0090129)2.75606838
53regulation of voltage-gated calcium channel activity (GO:1901385)2.75426959
54peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.73433627
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73348125
56behavioral response to ethanol (GO:0048149)2.72643411
57apical protein localization (GO:0045176)2.71661147
58regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.70878574
59regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.69965184
60protein targeting to Golgi (GO:0000042)2.67600772
61regulation of guanylate cyclase activity (GO:0031282)2.67556607
62* regulation of synaptic vesicle exocytosis (GO:2000300)2.64499276
63phosphorelay signal transduction system (GO:0000160)2.62097798
64locomotory exploration behavior (GO:0035641)2.59892498
65nonmotile primary cilium assembly (GO:0035058)2.58202655
66chemosensory behavior (GO:0007635)2.57494919
67regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.56970567
68establishment of protein localization to Golgi (GO:0072600)2.56216323
69* membrane hyperpolarization (GO:0060081)2.55660453
70regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.55248272
71membrane repolarization (GO:0086009)2.54904493
72regulation of calcium ion-dependent exocytosis (GO:0017158)2.54794610
73cytoskeletal anchoring at plasma membrane (GO:0007016)2.51849136
74regulation of glutamate receptor signaling pathway (GO:1900449)2.51098592
75response to histamine (GO:0034776)2.50438889
76membrane repolarization during action potential (GO:0086011)2.49693986
77camera-type eye morphogenesis (GO:0048593)2.49223669
78neurotransmitter secretion (GO:0007269)2.48993195
79neuron cell-cell adhesion (GO:0007158)2.48321941
80* innervation (GO:0060384)2.48311899
81establishment of nucleus localization (GO:0040023)2.47711037
82neuron projection extension involved in neuron projection guidance (GO:1902284)2.47421581
83axon extension involved in axon guidance (GO:0048846)2.47421581
84positive regulation of sodium ion transmembrane transport (GO:1902307)2.46720812
85pyrimidine nucleobase catabolic process (GO:0006208)2.45753417
86membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.44223196
87axonal fasciculation (GO:0007413)2.43909136
88neuron recognition (GO:0008038)2.42080521
89cardiac myofibril assembly (GO:0055003)2.38149448
90retrograde transport, vesicle recycling within Golgi (GO:0000301)2.37272185
91cell communication involved in cardiac conduction (GO:0086065)2.36713993
92positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.36472693
93positive regulation of vesicle fusion (GO:0031340)2.36376090
94* regulation of synaptic vesicle transport (GO:1902803)2.36059390
95nucleus localization (GO:0051647)2.35415414
96retina layer formation (GO:0010842)2.34351960
97carnitine shuttle (GO:0006853)2.34254991
98regulation of cGMP metabolic process (GO:0030823)2.34132529
99positive regulation of smoothened signaling pathway (GO:0045880)2.33603632
100urinary tract smooth muscle contraction (GO:0014848)2.33523686
101cochlea development (GO:0090102)2.32941272
102notochord development (GO:0030903)2.32409741
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.32010368
104synapse assembly (GO:0007416)2.31869265
105peripheral nervous system axon ensheathment (GO:0032292)2.31230305
106myelination in peripheral nervous system (GO:0022011)2.31230305
107epithelial cell-cell adhesion (GO:0090136)2.31226195
108startle response (GO:0001964)2.29126008
109regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.28902933
110receptor recycling (GO:0001881)2.28570505
111calcium ion import (GO:0070509)2.28504045
112positive regulation of cGMP biosynthetic process (GO:0030828)2.28081875
113* regulation of postsynaptic membrane potential (GO:0060078)2.27523113
114ovulation cycle (GO:0042698)2.27294777
115retina vasculature morphogenesis in camera-type eye (GO:0061299)2.26538034
116stress granule assembly (GO:0034063)2.26089386
117asymmetric protein localization (GO:0008105)2.25847100
118membrane depolarization during action potential (GO:0086010)2.25443433
119regulation of excitatory postsynaptic membrane potential (GO:0060079)2.25305297
120myofibril assembly (GO:0030239)2.24854545
121plasma membrane repair (GO:0001778)2.24475873
122myoblast fusion (GO:0007520)2.22419022
123biotin metabolic process (GO:0006768)2.21994534
124hippo signaling (GO:0035329)2.20585938
125embryonic foregut morphogenesis (GO:0048617)2.19895334
126macroautophagy (GO:0016236)2.18730249
127actin-myosin filament sliding (GO:0033275)2.18238227
128muscle filament sliding (GO:0030049)2.18238227
129sarcoplasmic reticulum calcium ion transport (GO:0070296)2.16678061
130planar cell polarity pathway involved in neural tube closure (GO:0090179)2.16626683
131carnitine transmembrane transport (GO:1902603)2.15532531
132lymphangiogenesis (GO:0001946)2.15477803
133neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.14561031
134midgut development (GO:0007494)2.14450041
135nucleobase catabolic process (GO:0046113)2.13573445
136establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.13157294
137phosphate ion transmembrane transport (GO:0035435)2.12500400
138actin-mediated cell contraction (GO:0070252)2.12315631
139axon extension (GO:0048675)2.11733965
140gap junction assembly (GO:0016264)2.10915132
141bundle of His cell to Purkinje myocyte communication (GO:0086069)2.10109602
142regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.08406267
143gastrulation with mouth forming second (GO:0001702)2.07845054
144regulation of cardioblast differentiation (GO:0051890)2.07506384
145amino-acid betaine transport (GO:0015838)2.05531288
146carnitine transport (GO:0015879)2.05531288
147morphogenesis of an epithelial sheet (GO:0002011)2.02874622
148neuronal ion channel clustering (GO:0045161)2.01311212
149actomyosin structure organization (GO:0031032)1.98900545
150establishment of apical/basal cell polarity (GO:0035089)1.97340780
151regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.96402389
152ethanol oxidation (GO:0006069)1.96271985
153* neuromuscular junction development (GO:0007528)1.96107131
154establishment or maintenance of apical/basal cell polarity (GO:0035088)1.96105278
155establishment or maintenance of bipolar cell polarity (GO:0061245)1.96105278
156actin filament-based movement (GO:0030048)1.96064936
157establishment of monopolar cell polarity (GO:0061162)1.95774059
158establishment or maintenance of monopolar cell polarity (GO:0061339)1.95774059
159cell migration in hindbrain (GO:0021535)1.95017076
160quaternary ammonium group transport (GO:0015697)1.94855951
161regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.94768167
162convergent extension (GO:0060026)1.93562787
163myotube differentiation (GO:0014902)1.93353336
164ventricular cardiac muscle cell action potential (GO:0086005)1.92747649
165mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)1.92021512
166ectodermal placode formation (GO:0060788)1.91559934
167artery development (GO:0060840)1.91228384
168sarcomere organization (GO:0045214)1.90451195
169positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)1.90011431
170syncytium formation by plasma membrane fusion (GO:0000768)1.89343578
171adult heart development (GO:0007512)1.87495818
172insulin-like growth factor receptor signaling pathway (GO:0048009)1.85775430
173positive regulation of dendritic spine morphogenesis (GO:0061003)1.85720112
174sodium ion homeostasis (GO:0055078)1.85282572
175G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.84154249
176phosphate ion transport (GO:0006817)1.82987063
177regulation of hippo signaling (GO:0035330)1.82824652
178Wnt signaling pathway, planar cell polarity pathway (GO:0060071)1.82472345
179desmosome organization (GO:0002934)1.82268352
180dorsal/ventral axis specification (GO:0009950)1.82151407
181dichotomous subdivision of an epithelial terminal unit (GO:0060600)1.81909514
182cell migration involved in sprouting angiogenesis (GO:0002042)1.81881462
183lung epithelium development (GO:0060428)1.81364359
184neurotransmitter-gated ion channel clustering (GO:0072578)1.81160270
185ethanol metabolic process (GO:0006067)1.81004525
186ephrin receptor signaling pathway (GO:0048013)1.79539304
187fatty acid transmembrane transport (GO:1902001)1.79390723
188regulation of establishment of planar polarity (GO:0090175)1.78953584
189developmental cell growth (GO:0048588)1.77813633
190cellular sodium ion homeostasis (GO:0006883)1.77582472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.44308491
2EZH2_22144423_ChIP-Seq_EOC_Human3.44074399
3DROSHA_22980978_ChIP-Seq_HELA_Human2.24857809
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18466555
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12798579
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09632983
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05773606
8* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.98591711
9JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95819146
10RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93272702
11EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93272702
12EZH2_27304074_Chip-Seq_ESCs_Mouse1.91460440
13RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91168429
14JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82739205
15RNF2_27304074_Chip-Seq_ESCs_Mouse1.82115719
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81780929
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78674684
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77309425
19REST_21632747_ChIP-Seq_MESCs_Mouse1.76361476
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.72979428
21SMAD4_21799915_ChIP-Seq_A2780_Human1.70684444
22* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70678991
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.68796168
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.67243999
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.65958125
26AHR_22903824_ChIP-Seq_MCF-7_Human1.64692804
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62173019
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60748759
29ARNT_22903824_ChIP-Seq_MCF-7_Human1.60291502
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59038223
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.58518143
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.56461199
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.54547846
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54183663
35* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52678255
36CLOCK_20551151_ChIP-Seq_293T_Human1.52014152
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51118831
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51113051
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50636363
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48143869
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.47692761
42* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46487738
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46156071
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45950701
45* STAT3_23295773_ChIP-Seq_U87_Human1.45578880
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44760909
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42973649
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42519079
49AR_19668381_ChIP-Seq_PC3_Human1.41783843
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40294035
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.39484072
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36876129
53IGF1R_20145208_ChIP-Seq_DFB_Human1.36375966
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35616630
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.35063268
56TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34996750
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.34068936
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.33299869
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.33060267
60P53_22127205_ChIP-Seq_FIBROBLAST_Human1.32999657
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.30866524
62SMAD3_21741376_ChIP-Seq_HESCs_Human1.30219389
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29002245
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.28955384
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28871334
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.28575711
67TCF4_23295773_ChIP-Seq_U87_Human1.27422441
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27422171
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.26908707
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26388341
71* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.26005236
72BCAT_22108803_ChIP-Seq_LS180_Human1.25732123
73P300_19829295_ChIP-Seq_ESCs_Human1.25272114
74* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25115608
75AR_21572438_ChIP-Seq_LNCaP_Human1.24509453
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.24394473
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24134761
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24057742
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23251487
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22670972
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22564286
82* ISL1_27105846_Chip-Seq_CPCs_Mouse1.22554931
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.22200520
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22153776
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20765397
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20698113
87TP53_16413492_ChIP-PET_HCT116_Human1.20447271
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.20345210
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.20101662
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18875490
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17364422
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15848483
93ESR1_20079471_ChIP-ChIP_T-47D_Human1.15547211
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15492169
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14511172
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14204452
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14204452
98* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13535035
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13385291
100GATA1_26923725_Chip-Seq_HPCs_Mouse1.12251524
101KDM2B_26808549_Chip-Seq_K562_Human1.10281679
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10043791
103* AR_25329375_ChIP-Seq_VCAP_Human1.09797316
104SMAD4_21741376_ChIP-Seq_HESCs_Human1.09637919
105SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09387502
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08983530
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06950800
108ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06912814
109RING1B_27294783_Chip-Seq_ESCs_Mouse1.06746490
110ZNF274_21170338_ChIP-Seq_K562_Hela1.06481625
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06300449
112FUS_26573619_Chip-Seq_HEK293_Human1.06057088
113RNF2_27304074_Chip-Seq_NSC_Mouse1.05994306
114SMAD3_21741376_ChIP-Seq_ESCs_Human1.05534167
115IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05273032
116LXR_22158963_ChIP-Seq_LIVER_Mouse1.04395762
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02860228
118TBX20_22328084_ChIP-Seq_HEART_Mouse1.02585144
119TBX20_22080862_ChIP-Seq_HEART_Mouse1.02585144
120ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02417200
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01540813
122ERG_21242973_ChIP-ChIP_JURKAT_Human1.01407506
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.01012156
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00933624
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00364858
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99303026
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99078658
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99078658
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.98363017
130RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98289368
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97131005
132FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95838105
133OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93280443

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog5.73371385
2MP0003011_delayed_dark_adaptation4.47850826
3MP0006072_abnormal_retinal_apoptosis4.42788087
4MP0005253_abnormal_eye_physiology4.14131871
5MP0009780_abnormal_chondrocyte_physiolo2.72898882
6MP0004859_abnormal_synaptic_plasticity2.64692161
7MP0005195_abnormal_posterior_eye2.40247976
8MP0004270_analgesia2.35873677
9MP0002653_abnormal_ependyma_morphology2.35524785
10MP0003941_abnormal_skin_development2.23713310
11MP0002090_abnormal_vision2.20524162
12MP0003880_abnormal_central_pattern2.17869868
13MP0004272_abnormal_basement_membrane2.04504096
14MP0005391_vision/eye_phenotype1.99187036
15MP0003787_abnormal_imprinting1.99149012
16MP0010030_abnormal_orbit_morphology1.97664705
17MP0005423_abnormal_somatic_nervous1.95311721
18MP0001324_abnormal_eye_pigmentation1.94518989
19MP0003635_abnormal_synaptic_transmissio1.92638111
20MP0001299_abnormal_eye_distance/1.89673562
21MP0010386_abnormal_urinary_bladder1.89186523
22MP0002638_abnormal_pupillary_reflex1.86497910
23MP0001984_abnormal_olfaction1.83603463
24MP0002229_neurodegeneration1.78004231
25MP0000566_synostosis1.77636939
26MP0010368_abnormal_lymphatic_system1.73079864
27MP0002822_catalepsy1.70632409
28MP0004782_abnormal_surfactant_physiolog1.67781528
29MP0003950_abnormal_plasma_membrane1.67335063
30MP0005248_abnormal_Harderian_gland1.60718046
31MP0002063_abnormal_learning/memory/cond1.60036058
32MP0000462_abnormal_digestive_system1.58541336
33MP0004233_abnormal_muscle_weight1.58169376
34MP0001502_abnormal_circadian_rhythm1.58109679
35MP0002734_abnormal_mechanical_nocicepti1.56945640
36MP0005394_taste/olfaction_phenotype1.55689356
37MP0005499_abnormal_olfactory_system1.55689356
38MP0001486_abnormal_startle_reflex1.51914924
39MP0010234_abnormal_vibrissa_follicle1.51416330
40MP0002752_abnormal_somatic_nervous1.51328311
41MP0003705_abnormal_hypodermis_morpholog1.50543278
42MP0002882_abnormal_neuron_morphology1.48067539
43MP0003879_abnormal_hair_cell1.44712479
44MP0005187_abnormal_penis_morphology1.43251088
45MP0000778_abnormal_nervous_system1.41662617
46MP0004885_abnormal_endolymph1.32828647
47MP0008789_abnormal_olfactory_epithelium1.32244143
48MP0003890_abnormal_embryonic-extraembry1.30675872
49MP0002909_abnormal_adrenal_gland1.30344540
50MP0001968_abnormal_touch/_nociception1.30035974
51MP0002572_abnormal_emotion/affect_behav1.29905154
52MP0002272_abnormal_nervous_system1.29715648
53MP0005409_darkened_coat_color1.28337088
54MP0000749_muscle_degeneration1.27455600
55MP0009745_abnormal_behavioral_response1.26987628
56MP0004087_abnormal_muscle_fiber1.25653356
57MP0002697_abnormal_eye_size1.24896604
58MP0005257_abnormal_intraocular_pressure1.24595068
59MP0002184_abnormal_innervation1.24326432
60MP0008877_abnormal_DNA_methylation1.22829431
61MP0008995_early_reproductive_senescence1.21877889
62MP0000569_abnormal_digit_pigmentation1.21105298
63MP0003942_abnormal_urinary_system1.20322902
64MP0003045_fibrosis1.19679287
65* MP0002064_seizures1.16613422
66MP0003937_abnormal_limbs/digits/tail_de1.16236309
67MP0000631_abnormal_neuroendocrine_gland1.14566546
68MP0002108_abnormal_muscle_morphology1.12840244
69MP0003566_abnormal_cell_adhesion1.12830707
70MP0000747_muscle_weakness1.12508154
71MP0004145_abnormal_muscle_electrophysio1.12282677
72MP0009046_muscle_twitch1.11413344
73MP0006292_abnormal_olfactory_placode1.11092294
74MP0010352_gastrointestinal_tract_polyps1.10847403
75MP0003115_abnormal_respiratory_system1.10698656
76MP0002557_abnormal_social/conspecific_i1.09389324
77MP0005670_abnormal_white_adipose1.08220742
78MP0003868_abnormal_feces_composition1.07750221
79MP0002067_abnormal_sensory_capabilities1.07505316
80MP0003385_abnormal_body_wall1.07417054
81MP0004043_abnormal_pH_regulation1.07105675
82MP0004215_abnormal_myocardial_fiber1.06781648
83MP0002139_abnormal_hepatobiliary_system1.06316017
84MP0002269_muscular_atrophy1.03318730
85MP0002233_abnormal_nose_morphology1.02208379
86MP0005365_abnormal_bile_salt0.99520769
87MP0009672_abnormal_birth_weight0.97305789
88MP0000013_abnormal_adipose_tissue0.97090386
89MP0006138_congestive_heart_failure0.96247395
90MP0004264_abnormal_extraembryonic_tissu0.95334545
91MP0005646_abnormal_pituitary_gland0.95239173
92MP0002127_abnormal_cardiovascular_syste0.95193063
93MP0004085_abnormal_heartbeat0.94710081
94MP0002234_abnormal_pharynx_morphology0.94199880
95MP0000759_abnormal_skeletal_muscle0.93264076
96MP0001661_extended_life_span0.93092635
97MP0001958_emphysema0.92823660
98MP0001666_abnormal_nutrient_absorption0.92694400
99MP0000751_myopathy0.90003300
100MP0001879_abnormal_lymphatic_vessel0.88493821
101MP0005369_muscle_phenotype0.87048483
102MP0010630_abnormal_cardiac_muscle0.86577451
103MP0003283_abnormal_digestive_organ0.86213049
104MP0002896_abnormal_bone_mineralization0.85904885
105MP0000762_abnormal_tongue_morphology0.85626516
106MP0002106_abnormal_muscle_physiology0.85192578
107MP0000534_abnormal_ureter_morphology0.84989193
108MP0001346_abnormal_lacrimal_gland0.84468440
109MP0002152_abnormal_brain_morphology0.83212891
110MP0003935_abnormal_craniofacial_develop0.82910608
111MP0001440_abnormal_grooming_behavior0.82028958
112MP0003121_genomic_imprinting0.81964284
113MP0001963_abnormal_hearing_physiology0.81946065
114MP0005645_abnormal_hypothalamus_physiol0.81871987
115MP0009703_decreased_birth_body0.81679226
116MP0004811_abnormal_neuron_physiology0.80670070
117MP0005386_behavior/neurological_phenoty0.80072284
118MP0004924_abnormal_behavior0.80072284
119MP0004133_heterotaxia0.78442349
120MP0010678_abnormal_skin_adnexa0.78296989
121MP0000955_abnormal_spinal_cord0.78055739
122MP0000733_abnormal_muscle_development0.77792335
123MP0004084_abnormal_cardiac_muscle0.77577566
124MP0002084_abnormal_developmental_patter0.77229785
125MP0003119_abnormal_digestive_system0.77008207
126MP0004130_abnormal_muscle_cell0.76555799
127MP0003755_abnormal_palate_morphology0.76055555
128MP0001188_hyperpigmentation0.75988779
129MP0001849_ear_inflammation0.75793363
130MP0002089_abnormal_postnatal_growth/wei0.75618756
131MP0002249_abnormal_larynx_morphology0.75384220
132MP0003122_maternal_imprinting0.75378122
133MP0004036_abnormal_muscle_relaxation0.74776812
134MP0002092_abnormal_eye_morphology0.74309726
135MP0000428_abnormal_craniofacial_morphol0.72058727
136MP0005377_hearing/vestibular/ear_phenot0.71540105
137MP0003878_abnormal_ear_physiology0.71540105
138MP0000432_abnormal_head_morphology0.71453939
139MP0001970_abnormal_pain_threshold0.71286395
140MP0003861_abnormal_nervous_system0.71280684
141MP0000579_abnormal_nail_morphology0.70815165
142MP0004858_abnormal_nervous_system0.70370992
143MP0008961_abnormal_basal_metabolism0.69433384
144MP0003634_abnormal_glial_cell0.69115551
145MP0001293_anophthalmia0.68561383
146MP0005623_abnormal_meninges_morphology0.68061867
147MP0001485_abnormal_pinna_reflex0.66814853
148MP0001944_abnormal_pancreas_morphology0.65253199
149MP0002736_abnormal_nociception_after0.64458194
150MP0003698_abnormal_male_reproductive0.63559213
151MP0001501_abnormal_sleep_pattern0.63247640
152MP0008569_lethality_at_weaning0.62543629
153MP0002733_abnormal_thermal_nociception0.61726251
154MP0006276_abnormal_autonomic_nervous0.61374983
155MP0005620_abnormal_muscle_contractility0.60992679
156MP0002735_abnormal_chemical_nociception0.60739358
157MP0000537_abnormal_urethra_morphology0.60665709
158MP0002102_abnormal_ear_morphology0.60518073
159MP0001177_atelectasis0.60473856
160MP0004742_abnormal_vestibular_system0.60252476

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)9.76731558
2Bony spicule pigmentary retinopathy (HP:0007737)7.78991593
3Central scotoma (HP:0000603)6.92867938
4Abnormal rod and cone electroretinograms (HP:0008323)6.47531965
5Abnormality of macular pigmentation (HP:0008002)6.34043926
6Absent rod-and cone-mediated responses on ERG (HP:0007688)6.31484179
7Scotoma (HP:0000575)5.73451803
8Pendular nystagmus (HP:0012043)5.49782352
9Chorioretinal atrophy (HP:0000533)5.40128430
10Dyschromatopsia (HP:0007641)5.22587340
11Pigmentary retinal degeneration (HP:0001146)4.88389036
12Decreased central vision (HP:0007663)4.84977426
13Attenuation of retinal blood vessels (HP:0007843)4.68333840
14Abolished electroretinogram (ERG) (HP:0000550)4.63465890
15Type II diabetes mellitus (HP:0005978)4.05248603
16Severe visual impairment (HP:0001141)4.03725031
17Cone-rod dystrophy (HP:0000548)3.86941136
18Posterior subcapsular cataract (HP:0007787)3.76359042
19Macular degeneration (HP:0000608)3.53719296
20Photophobia (HP:0000613)3.52585353
21Keratoconus (HP:0000563)3.52045722
22Increased corneal curvature (HP:0100692)3.52045722
23Congenital sensorineural hearing impairment (HP:0008527)2.96320500
24Vitreoretinal degeneration (HP:0000655)2.94447290
25Choroideremia (HP:0001139)2.92823913
26Subcapsular cataract (HP:0000523)2.92756211
27Retinitis pigmentosa (HP:0000510)2.89206329
28Constricted visual fields (HP:0001133)2.86383465
29Epileptic encephalopathy (HP:0200134)2.84829937
30Muscle fiber inclusion bodies (HP:0100299)2.69934695
31Type 1 muscle fiber predominance (HP:0003803)2.67469100
32Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.60572721
33Exercise-induced myalgia (HP:0003738)2.56958960
34Nemaline bodies (HP:0003798)2.47826328
35Febrile seizures (HP:0002373)2.46142031
36Exercise-induced muscle cramps (HP:0003710)2.37249838
37Hyperkalemia (HP:0002153)2.31675939
38Aplasia involving bones of the extremities (HP:0009825)2.30630604
39Aplasia involving bones of the upper limbs (HP:0009823)2.30630604
40Aplasia of the phalanges of the hand (HP:0009802)2.30630604
41Hepatoblastoma (HP:0002884)2.27159187
42Focal motor seizures (HP:0011153)2.24979716
43Decreased electroretinogram (ERG) amplitude (HP:0000654)2.24235980
44Bronchomalacia (HP:0002780)2.23608161
45Abnormality of the calf musculature (HP:0001430)2.22503576
46Rimmed vacuoles (HP:0003805)2.21902322
47Bundle branch block (HP:0011710)2.14147419
48Progressive visual loss (HP:0000529)2.13339818
49Muscle hypertrophy of the lower extremities (HP:0008968)2.10800985
50Calf muscle hypertrophy (HP:0008981)2.10709344
51Right ventricular cardiomyopathy (HP:0011663)2.09813528
52Gait imbalance (HP:0002141)2.08419313
53Mildly elevated creatine phosphokinase (HP:0008180)2.03497429
54Papillary thyroid carcinoma (HP:0002895)2.03188962
55Abnormality of the lower motor neuron (HP:0002366)2.02888495
56Prolonged QT interval (HP:0001657)2.02475509
57Genetic anticipation (HP:0003743)2.02001812
58Hyperactive renin-angiotensin system (HP:0000841)2.01552106
59Progressive cerebellar ataxia (HP:0002073)2.00124147
60Congenital primary aphakia (HP:0007707)1.98997682
61Retinal atrophy (HP:0001105)1.96998207
62Cortical dysplasia (HP:0002539)1.96176854
63Focal seizures (HP:0007359)1.93726510
64Shallow orbits (HP:0000586)1.90867330
65Cutaneous finger syndactyly (HP:0010554)1.87277688
66Broad metatarsal (HP:0001783)1.86062628
67Pancreatic fibrosis (HP:0100732)1.84462875
68Syncope (HP:0001279)1.81661404
69Overgrowth (HP:0001548)1.81602814
70Visual hallucinations (HP:0002367)1.81281371
71Turricephaly (HP:0000262)1.80986960
72Hemangiomatosis (HP:0007461)1.80481342
73Spinal rigidity (HP:0003306)1.80075513
74Interstitial pulmonary disease (HP:0006530)1.79869066
75Nephrogenic diabetes insipidus (HP:0009806)1.78382570
76Drooling (HP:0002307)1.77379726
77Excessive salivation (HP:0003781)1.77379726
78Medial flaring of the eyebrow (HP:0010747)1.76684316
79Cystic liver disease (HP:0006706)1.74924666
80Male infertility (HP:0003251)1.74792359
81Submucous cleft hard palate (HP:0000176)1.74432192
82Difficulty running (HP:0009046)1.74366636
83Absence seizures (HP:0002121)1.74245482
84Cutaneous syndactyly (HP:0012725)1.73955277
85Visceral angiomatosis (HP:0100761)1.70680740
86Lymphangioma (HP:0100764)1.70525179
87Macroorchidism (HP:0000053)1.70487978
88Intrahepatic cholestasis (HP:0001406)1.70153176
89Neonatal short-limb short stature (HP:0008921)1.70034172
90Wide nasal bridge (HP:0000431)1.69401162
91Hyporeflexia of lower limbs (HP:0002600)1.69306706
92Abnormality of permanent molar morphology (HP:0011071)1.65856829
93Abnormality of the dental root (HP:0006486)1.65856829
94Taurodontia (HP:0000679)1.65856829
95Hypoventilation (HP:0002791)1.65852380
96Genital tract atresia (HP:0001827)1.65246792
97Amblyopia (HP:0000646)1.64838526
98Hammertoe (HP:0001765)1.63133449
99Dysdiadochokinesis (HP:0002075)1.62023160
100Poor coordination (HP:0002370)1.61959348
101Elfin facies (HP:0004428)1.61880463
102Abnormality of the ischium (HP:0003174)1.61616401
103Abnormality of the dental pulp (HP:0006479)1.61531910
104Polar cataract (HP:0010696)1.61462573
105Choanal stenosis (HP:0000452)1.61430694
106Vaginal atresia (HP:0000148)1.59579953
107Limited hip movement (HP:0008800)1.58960124
108Abnormality of molar morphology (HP:0011070)1.58751541
109Abnormality of molar (HP:0011077)1.58751541
110Hyperventilation (HP:0002883)1.58472585
111Epileptiform EEG discharges (HP:0011182)1.57736631
112Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.57724775
113Truncal ataxia (HP:0002078)1.57489491
114Distal arthrogryposis (HP:0005684)1.57460273
115Male pseudohermaphroditism (HP:0000037)1.57288065
116Gaze-evoked nystagmus (HP:0000640)1.56874696
117Coronal craniosynostosis (HP:0004440)1.56658307
118Atonic seizures (HP:0010819)1.55645926
119Ventricular fibrillation (HP:0001663)1.55352973
120Sudden death (HP:0001699)1.54241612
121Protrusio acetabuli (HP:0003179)1.54127626
122Frequent falls (HP:0002359)1.54036611
123Severe Myopia (HP:0011003)1.52799461
124Limb-girdle muscle atrophy (HP:0003797)1.52749118
125Renovascular hypertension (HP:0100817)1.52199000
126EEG with generalized epileptiform discharges (HP:0011198)1.52095047
127Flat acetabular roof (HP:0003180)1.50808199
128Generalized tonic-clonic seizures (HP:0002069)1.50668479
129Advanced eruption of teeth (HP:0006288)1.50456865
130Mixed hearing impairment (HP:0000410)1.49956892
131Midline defect of the nose (HP:0004122)1.49811002
132Increased variability in muscle fiber diameter (HP:0003557)1.49297234
133Broad-based gait (HP:0002136)1.49011804
134Lower limb amyotrophy (HP:0007210)1.48416694
135Dysmetric saccades (HP:0000641)1.47716840
136Cervical subluxation (HP:0003308)1.46817430
137Abnormal pancreas size (HP:0012094)1.46797936
138Centrally nucleated skeletal muscle fibers (HP:0003687)1.46602638
139True hermaphroditism (HP:0010459)1.46535249
140Distal upper limb amyotrophy (HP:0007149)1.46534985
141Upper limb amyotrophy (HP:0009129)1.46534985
142Abnormality of dentin (HP:0010299)1.45925751
143Bifid scrotum (HP:0000048)1.45766405
144Back pain (HP:0003418)1.45730389
145Insomnia (HP:0100785)1.45430156
146Ependymoma (HP:0002888)1.45293788
147Germ cell neoplasia (HP:0100728)1.44975957
148Skin nodule (HP:0200036)1.44380243
149Hypoalphalipoproteinemia (HP:0003233)1.44105805
150Abnormality of the astrocytes (HP:0100707)1.43858901
151Astrocytoma (HP:0009592)1.43858901
152Late onset (HP:0003584)1.43731997
153Exotropia (HP:0000577)1.43717467
154Urinary bladder sphincter dysfunction (HP:0002839)1.43515966
155Abnormal EKG (HP:0003115)1.43500557
156Increased connective tissue (HP:0009025)1.42189261
157Abnormal atrioventricular conduction (HP:0005150)1.41785502
158Abnormality of monocarboxylic acid metabolism (HP:0010996)1.41737074
159EMG: myopathic abnormalities (HP:0003458)1.41061526
160Alacrima (HP:0000522)1.40914212
161Heart block (HP:0012722)1.40672000
162Decreased circulating renin level (HP:0003351)1.40572032
163Myopathic facies (HP:0002058)1.40537885
164Precocious puberty (HP:0000826)1.40197639
165Scapular winging (HP:0003691)1.39940489
166Abnormality of pain sensation (HP:0010832)1.39731916
167Impaired pain sensation (HP:0007328)1.39731916
168Chronic bronchitis (HP:0004469)1.38356591
169Wrist flexion contracture (HP:0001239)1.38203244
170Hand muscle atrophy (HP:0009130)1.38049066
171Distal lower limb amyotrophy (HP:0008944)1.37942653
172Insulin-resistant diabetes mellitus (HP:0000831)1.37839981
173Spastic diplegia (HP:0001264)1.37417297
174Dialeptic seizures (HP:0011146)1.37207462
175Complement deficiency (HP:0004431)1.37067038
176Vertebral arch anomaly (HP:0008438)1.36310982
177Muscle fiber splitting (HP:0003555)1.35768704
178Arterial tortuosity (HP:0005116)1.35714971
179Ankle clonus (HP:0011448)1.35598318
180Thyroid carcinoma (HP:0002890)1.34747945
181Nephronophthisis (HP:0000090)1.34704165
182Volvulus (HP:0002580)1.34480522
183Depression (HP:0000716)1.34012381
184Absent speech (HP:0001344)1.32715917
185Chronic hepatic failure (HP:0100626)1.32247757
186Obsessive-compulsive behavior (HP:0000722)1.31152969
187Aplasia/Hypoplasia of the lens (HP:0008063)1.30615807
188Mask-like facies (HP:0000298)1.29461851
189Myokymia (HP:0002411)1.29379620
190Abnormality of midbrain morphology (HP:0002418)1.28906501
191Molar tooth sign on MRI (HP:0002419)1.28906501
192Neoplasm of the heart (HP:0100544)1.28086399
193Testicular neoplasm (HP:0010788)1.28002038
194Absent eyebrow (HP:0002223)1.27364588

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K43.28783795
2OBSCN2.98912909
3GRK12.85418434
4LATS12.81251934
5AKT32.75370672
6EEF2K2.42851369
7INSRR2.33528177
8PRKD32.30340657
9NTRK32.21481802
10EPHA42.21253443
11MARK12.14712332
12DAPK22.11740397
13TTN1.99812161
14MAP2K71.97377414
15STK381.93353391
16MAP3K91.91343502
17FRK1.85190194
18CAMK1G1.85010273
19CASK1.79730031
20MET1.68846671
21PAK61.61668157
22BRD41.61173624
23EPHA31.53304901
24CDK121.53085046
25RIPK11.51495107
26TIE11.50350051
27EPHA21.43332515
28LMTK21.40282566
29MAP2K41.39972181
30CAMK1D1.39946828
31MAP3K21.39686053
32MST1R1.36298744
33SGK21.33068197
34NUAK11.26926033
35SGK2231.25082037
36SGK4941.25082037
37FER1.21785964
38DMPK1.17690851
39TRIB31.17613800
40MINK11.16391743
41PNCK1.15754865
42TYRO31.15540707
43STK38L1.10640451
44MAP3K61.09597327
45FGFR41.09493787
46CDC42BPA1.08859513
47KSR11.08385385
48PLK21.08121918
49ICK1.05611919
50TNIK1.05327514
51SGK31.05155193
52PTK21.03886665
53WNK31.01799527
54DYRK1A1.00774283
55PKN21.00388379
56PINK10.98524905
57MAPK130.95116919
58PAK30.94931587
59NTRK20.94155745
60WNK10.92363054
61TAOK30.92271482
62KSR20.91603993
63CDK50.91082091
64PHKG20.89685697
65PHKG10.89685697
66PRKAA20.87285518
67RET0.84689980
68PDGFRA0.80612701
69CAMKK10.78285101
70ERBB30.77941299
71SGK10.76090491
72ERBB20.76052385
73LATS20.76048445
74NTRK10.75446712
75DAPK10.75332523
76FGFR20.75264152
77DDR20.74911972
78PRKAA10.74785196
79PDGFRB0.74755222
80MYLK0.70221217
81MAPK150.69055489
82PAK20.68715805
83PRKCH0.68417891
84HIPK20.68032951
85FGFR30.65981895
86CDK30.64700839
87PTK2B0.64563576
88CSNK1G10.64526693
89CDK90.64404763
90WNK40.64060442
91EPHB20.63113069
92CAMK10.62907670
93CAMK2A0.60683280
94CSNK1G20.59280205
95PRKCZ0.57847456
96STK390.57593863
97DYRK1B0.56888707
98CAMK2D0.56430203
99MARK20.56361599
100SIK20.55490152
101RPS6KA30.55195286
102STK110.54481716
103CSNK1A1L0.53463710
104PRPF4B0.53335254
105ADRBK10.53221107
106CAMK40.52325766
107MAP3K70.51524966
108STK30.51136200
109DYRK20.49696926
110* GSK3B0.49092217
111ERBB40.49001484
112PBK0.47232803
113FGFR10.46829734
114RPS6KA20.46725713
115PIK3CA0.46473735
116AKT20.46399624
117CSNK1D0.45845164
118MAPK100.45548410
119PRKCE0.45307115
120PRKCB0.45118634
121MTOR0.44115831
122TTK0.43960645
123ROCK20.42885376
124NEK10.42838421
125CSNK1E0.42087413
126ROCK10.41990564
127PRKCG0.41854757
128PAK40.41842330
129SCYL20.40913325
130RPS6KB10.40323951
131CAMK2B0.40170193
132PDK20.39936691
133BCR0.39580753
134PRKG20.37201951
135PRKDC0.36836082

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047447.51612001
2* Synaptic vesicle cycle_Homo sapiens_hsa047212.26896756
3Nicotine addiction_Homo sapiens_hsa050332.20809921
4Olfactory transduction_Homo sapiens_hsa047402.09345783
5Insulin secretion_Homo sapiens_hsa049112.08986082
6Circadian entrainment_Homo sapiens_hsa047132.02417155
7GABAergic synapse_Homo sapiens_hsa047272.00646947
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93733640
9Morphine addiction_Homo sapiens_hsa050321.74954925
10Glutamatergic synapse_Homo sapiens_hsa047241.72922477
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65616777
12Dopaminergic synapse_Homo sapiens_hsa047281.64607650
13Long-term potentiation_Homo sapiens_hsa047201.63284906
14Arginine biosynthesis_Homo sapiens_hsa002201.61775610
15Amphetamine addiction_Homo sapiens_hsa050311.56373008
16Cholinergic synapse_Homo sapiens_hsa047251.56031114
17Salivary secretion_Homo sapiens_hsa049701.55406832
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53640819
19Renin secretion_Homo sapiens_hsa049241.52409902
20Circadian rhythm_Homo sapiens_hsa047101.52092401
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49816210
22Histidine metabolism_Homo sapiens_hsa003401.49149707
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46955264
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42005828
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35014180
26Bile secretion_Homo sapiens_hsa049761.34019873
27Gastric acid secretion_Homo sapiens_hsa049711.32997394
28Oxytocin signaling pathway_Homo sapiens_hsa049211.32842685
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32238421
30Fatty acid degradation_Homo sapiens_hsa000711.30791080
31Phenylalanine metabolism_Homo sapiens_hsa003601.27216593
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.27048313
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25112654
34Type II diabetes mellitus_Homo sapiens_hsa049301.24479982
35Serotonergic synapse_Homo sapiens_hsa047261.22267521
36Taste transduction_Homo sapiens_hsa047421.21809686
37Arginine and proline metabolism_Homo sapiens_hsa003301.21352025
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.18970438
39Dilated cardiomyopathy_Homo sapiens_hsa054141.16079249
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15795899
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15576351
42cAMP signaling pathway_Homo sapiens_hsa040241.15532862
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15156282
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14010335
45Pancreatic secretion_Homo sapiens_hsa049721.13198869
46Fatty acid metabolism_Homo sapiens_hsa012121.12340528
47beta-Alanine metabolism_Homo sapiens_hsa004101.09124732
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07669221
49Propanoate metabolism_Homo sapiens_hsa006401.03561263
50Cocaine addiction_Homo sapiens_hsa050301.03466208
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.03105673
52Calcium signaling pathway_Homo sapiens_hsa040201.01963740
53Pyruvate metabolism_Homo sapiens_hsa006201.01823842
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01238180
55GnRH signaling pathway_Homo sapiens_hsa049121.00957109
56Axon guidance_Homo sapiens_hsa043600.99042750
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98346329
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97509463
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.97129432
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.97104663
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96739309
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96340821
63Gap junction_Homo sapiens_hsa045400.96261565
64Vibrio cholerae infection_Homo sapiens_hsa051100.95237801
65mTOR signaling pathway_Homo sapiens_hsa041500.94645100
66Steroid biosynthesis_Homo sapiens_hsa001000.93177044
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92694189
68Tyrosine metabolism_Homo sapiens_hsa003500.92407745
69Complement and coagulation cascades_Homo sapiens_hsa046100.92016987
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91595822
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91180993
72Retinol metabolism_Homo sapiens_hsa008300.90602966
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90445873
74Vitamin B6 metabolism_Homo sapiens_hsa007500.90206444
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89829085
76Glioma_Homo sapiens_hsa052140.89469214
77PPAR signaling pathway_Homo sapiens_hsa033200.88991288
78Estrogen signaling pathway_Homo sapiens_hsa049150.87912268
79Endometrial cancer_Homo sapiens_hsa052130.87851158
80Starch and sucrose metabolism_Homo sapiens_hsa005000.87703386
81ErbB signaling pathway_Homo sapiens_hsa040120.87153833
82Dorso-ventral axis formation_Homo sapiens_hsa043200.87000647
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86797108
84Melanogenesis_Homo sapiens_hsa049160.86697786
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85476532
86Butanoate metabolism_Homo sapiens_hsa006500.85358733
87Biosynthesis of amino acids_Homo sapiens_hsa012300.84664556
88Tryptophan metabolism_Homo sapiens_hsa003800.84462929
89Thyroid hormone synthesis_Homo sapiens_hsa049180.83849125
90Long-term depression_Homo sapiens_hsa047300.81916574
91Inositol phosphate metabolism_Homo sapiens_hsa005620.81014389
92Tight junction_Homo sapiens_hsa045300.80745408
93Fat digestion and absorption_Homo sapiens_hsa049750.77840524
94Carbon metabolism_Homo sapiens_hsa012000.77832138
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76861637
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74012320
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73867826
98Glucagon signaling pathway_Homo sapiens_hsa049220.73609879
99Wnt signaling pathway_Homo sapiens_hsa043100.73271126
100Adherens junction_Homo sapiens_hsa045200.73201433
101Hippo signaling pathway_Homo sapiens_hsa043900.72629686
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71870773
103Choline metabolism in cancer_Homo sapiens_hsa052310.70982382
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70068694
105Renin-angiotensin system_Homo sapiens_hsa046140.68467819
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67982760
107Collecting duct acid secretion_Homo sapiens_hsa049660.67761217
108Fructose and mannose metabolism_Homo sapiens_hsa000510.67666240
109ABC transporters_Homo sapiens_hsa020100.66711747
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66343881
111Mineral absorption_Homo sapiens_hsa049780.63120859
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62773696
113Protein digestion and absorption_Homo sapiens_hsa049740.62511445
114Ovarian steroidogenesis_Homo sapiens_hsa049130.62390532
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60319692
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.60260060
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.59629592
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.58431641
119Proteoglycans in cancer_Homo sapiens_hsa052050.58225441
120Lysine degradation_Homo sapiens_hsa003100.58164373
121Cardiac muscle contraction_Homo sapiens_hsa042600.58145294
122Chemical carcinogenesis_Homo sapiens_hsa052040.57631466
123MAPK signaling pathway_Homo sapiens_hsa040100.56228931
124Oocyte meiosis_Homo sapiens_hsa041140.54687738
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.54388832
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53356579
127Hedgehog signaling pathway_Homo sapiens_hsa043400.52453618
128Ras signaling pathway_Homo sapiens_hsa040140.50711995
129Renal cell carcinoma_Homo sapiens_hsa052110.50147959
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49367473
131Focal adhesion_Homo sapiens_hsa045100.48903809
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48276018
133Colorectal cancer_Homo sapiens_hsa052100.47531226
134ECM-receptor interaction_Homo sapiens_hsa045120.47503683
135Fatty acid biosynthesis_Homo sapiens_hsa000610.46060555
136Insulin signaling pathway_Homo sapiens_hsa049100.45904220
137VEGF signaling pathway_Homo sapiens_hsa043700.45625627
138Rap1 signaling pathway_Homo sapiens_hsa040150.43127850
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43000263
140Insulin resistance_Homo sapiens_hsa049310.42796229
141AMPK signaling pathway_Homo sapiens_hsa041520.42524803
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42358458
143Prolactin signaling pathway_Homo sapiens_hsa049170.40471992
144Basal cell carcinoma_Homo sapiens_hsa052170.39778870
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38978249
146Notch signaling pathway_Homo sapiens_hsa043300.38369902
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37936396

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