

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.70982108 |
| 2 | locomotory exploration behavior (GO:0035641) | 5.63840448 |
| 3 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.51021033 |
| 4 | retinal cone cell development (GO:0046549) | 5.46115976 |
| 5 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.46088554 |
| 6 | synaptic vesicle maturation (GO:0016188) | 5.20986832 |
| 7 | cellular potassium ion homeostasis (GO:0030007) | 4.94338968 |
| 8 | neuronal action potential propagation (GO:0019227) | 4.78987279 |
| 9 | prepulse inhibition (GO:0060134) | 4.78554452 |
| 10 | vocalization behavior (GO:0071625) | 4.67250264 |
| 11 | gamma-aminobutyric acid transport (GO:0015812) | 4.60508498 |
| 12 | synaptic vesicle exocytosis (GO:0016079) | 4.57831401 |
| 13 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.56297348 |
| 14 | regulation of female gonad development (GO:2000194) | 4.52879169 |
| 15 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.51806722 |
| 16 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.50387217 |
| 17 | regulation of synapse structural plasticity (GO:0051823) | 4.50321049 |
| 18 | piRNA metabolic process (GO:0034587) | 4.49405167 |
| 19 | neuromuscular process controlling posture (GO:0050884) | 4.48138473 |
| 20 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.41712573 |
| 21 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.39006305 |
| 22 | regulation of meiosis I (GO:0060631) | 4.37780980 |
| 23 | neurotransmitter secretion (GO:0007269) | 4.34227051 |
| 24 | regulation of DNA methylation (GO:0044030) | 4.30321782 |
| 25 | glutamate receptor signaling pathway (GO:0007215) | 4.29452443 |
| 26 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 4.28505884 |
| 27 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.28301916 |
| 28 | sodium ion export (GO:0071436) | 4.28074363 |
| 29 | neuron-neuron synaptic transmission (GO:0007270) | 4.24887692 |
| 30 | synaptic transmission, glutamatergic (GO:0035249) | 4.19415834 |
| 31 | striatum development (GO:0021756) | 4.15243963 |
| 32 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 4.14452543 |
| 33 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.14380283 |
| 34 | long-term memory (GO:0007616) | 4.10060427 |
| 35 | regulation of synaptic vesicle transport (GO:1902803) | 4.08480712 |
| 36 | regulation of neurotransmitter uptake (GO:0051580) | 4.01719492 |
| 37 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.00298159 |
| 38 | glutamate secretion (GO:0014047) | 3.98977547 |
| 39 | layer formation in cerebral cortex (GO:0021819) | 3.97746061 |
| 40 | protein localization to synapse (GO:0035418) | 3.97652995 |
| 41 | glycine transport (GO:0015816) | 3.94790147 |
| 42 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.94368928 |
| 43 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.94011873 |
| 44 | regulation of acrosome reaction (GO:0060046) | 3.91824957 |
| 45 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.89221994 |
| 46 | auditory behavior (GO:0031223) | 3.87540051 |
| 47 | DNA methylation involved in gamete generation (GO:0043046) | 3.86038421 |
| 48 | response to auditory stimulus (GO:0010996) | 3.80980551 |
| 49 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.79493609 |
| 50 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.78903497 |
| 51 | neuromuscular process controlling balance (GO:0050885) | 3.77016177 |
| 52 | phosphorelay signal transduction system (GO:0000160) | 3.76570584 |
| 53 | exploration behavior (GO:0035640) | 3.76119443 |
| 54 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.75763769 |
| 55 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.75510540 |
| 56 | positive regulation of membrane potential (GO:0045838) | 3.74730366 |
| 57 | synaptic transmission, dopaminergic (GO:0001963) | 3.68960311 |
| 58 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 3.65798267 |
| 59 | proline transport (GO:0015824) | 3.65153007 |
| 60 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.63486538 |
| 61 | transmission of nerve impulse (GO:0019226) | 3.63113889 |
| 62 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.61369801 |
| 63 | amino acid import (GO:0043090) | 3.61053522 |
| 64 | negative regulation of hormone biosynthetic process (GO:0032353) | 3.58764642 |
| 65 | negative regulation of hormone metabolic process (GO:0032351) | 3.58764642 |
| 66 | neurotransmitter transport (GO:0006836) | 3.55436481 |
| 67 | membrane hyperpolarization (GO:0060081) | 3.55384997 |
| 68 | positive regulation of synapse maturation (GO:0090129) | 3.52982057 |
| 69 | potassium ion homeostasis (GO:0055075) | 3.51788955 |
| 70 | behavioral response to cocaine (GO:0048148) | 3.51060265 |
| 71 | regulation of dopamine uptake involved in synaptic transmission (GO:0051584) | 3.47865617 |
| 72 | regulation of catecholamine uptake involved in synaptic transmission (GO:0051940) | 3.47865617 |
| 73 | long-term synaptic potentiation (GO:0060291) | 3.47629722 |
| 74 | neuron cell-cell adhesion (GO:0007158) | 3.46038948 |
| 75 | regulation of postsynaptic membrane potential (GO:0060078) | 3.44956040 |
| 76 | adult walking behavior (GO:0007628) | 3.44623683 |
| 77 | membrane depolarization during action potential (GO:0086010) | 3.43880467 |
| 78 | meiotic cell cycle (GO:0051321) | 3.43873231 |
| 79 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.43640344 |
| 80 | multicellular organism reproduction (GO:0032504) | 3.41861869 |
| 81 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.41121044 |
| 82 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.39419814 |
| 83 | regulation of neurotransmitter levels (GO:0001505) | 3.38898256 |
| 84 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.38849179 |
| 85 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.35729873 |
| 86 | potassium ion import (GO:0010107) | 3.35001130 |
| 87 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.31501862 |
| 88 | positive regulation of neurotransmitter transport (GO:0051590) | 3.31025822 |
| 89 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.30781529 |
| 90 | regulation of neurotransmitter transport (GO:0051588) | 3.30439182 |
| 91 | positive regulation of meiosis (GO:0045836) | 3.28992675 |
| 92 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 3.26467737 |
| 93 | cerebellar granule cell differentiation (GO:0021707) | 3.26396782 |
| 94 | cell communication by electrical coupling (GO:0010644) | 3.25869988 |
| 95 | dopamine receptor signaling pathway (GO:0007212) | 3.25197901 |
| 96 | behavioral defense response (GO:0002209) | 3.25022738 |
| 97 | behavioral fear response (GO:0001662) | 3.25022738 |
| 98 | axon ensheathment in central nervous system (GO:0032291) | 3.24807328 |
| 99 | central nervous system myelination (GO:0022010) | 3.24807328 |
| 100 | regulation of synaptic plasticity (GO:0048167) | 3.23434558 |
| 101 | serotonin metabolic process (GO:0042428) | 3.23260287 |
| 102 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.22264720 |
| 103 | postsynaptic membrane organization (GO:0001941) | 3.21900382 |
| 104 | dendritic spine morphogenesis (GO:0060997) | 3.21558233 |
| 105 | activation of protein kinase A activity (GO:0034199) | 3.21451155 |
| 106 | regulation of ARF protein signal transduction (GO:0032012) | 3.18710070 |
| 107 | response to pheromone (GO:0019236) | 3.16834079 |
| 108 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.16106452 |
| 109 | synaptic vesicle endocytosis (GO:0048488) | 3.15070212 |
| 110 | relaxation of smooth muscle (GO:0044557) | 3.14029925 |
| 111 | adenosine receptor signaling pathway (GO:0001973) | 3.14021049 |
| 112 | membrane depolarization (GO:0051899) | 3.13526779 |
| 113 | mating behavior (GO:0007617) | 3.13206938 |
| 114 | neuromuscular process (GO:0050905) | 3.11888119 |
| 115 | female gamete generation (GO:0007292) | 3.11599548 |
| 116 | positive regulation of potassium ion transport (GO:0043268) | 3.10753611 |
| 117 | primary amino compound metabolic process (GO:1901160) | 3.09407441 |
| 118 | neuronal ion channel clustering (GO:0045161) | 3.09067218 |
| 119 | presynaptic membrane assembly (GO:0097105) | 3.07743758 |
| 120 | regulation of neurotransmitter secretion (GO:0046928) | 3.07700430 |
| 121 | positive regulation of synaptic transmission (GO:0050806) | 3.04976433 |
| 122 | positive regulation of meiotic cell cycle (GO:0051446) | 3.04403400 |
| 123 | cochlea development (GO:0090102) | 3.04384428 |
| 124 | C4-dicarboxylate transport (GO:0015740) | 3.03251542 |
| 125 | L-amino acid import (GO:0043092) | 3.02137025 |
| 126 | startle response (GO:0001964) | 3.01943376 |
| 127 | visual learning (GO:0008542) | 3.01659935 |
| 128 | presynaptic membrane organization (GO:0097090) | 2.98991286 |
| 129 | calcium ion-dependent exocytosis (GO:0017156) | 2.94632172 |
| 130 | dopamine biosynthetic process (GO:0042416) | 2.87662156 |
| 131 | regulation of female receptivity (GO:0045924) | 2.84152373 |
| 132 | relaxation of cardiac muscle (GO:0055119) | 2.83659028 |
| 133 | regulation of synapse maturation (GO:0090128) | 2.78933482 |
| 134 | behavioral response to nicotine (GO:0035095) | 2.78572051 |
| 135 | potassium ion transmembrane transport (GO:0071805) | 2.78294837 |
| 136 | cellular potassium ion transport (GO:0071804) | 2.78294837 |
| 137 | detection of light stimulus involved in sensory perception (GO:0050962) | 2.77907446 |
| 138 | detection of light stimulus involved in visual perception (GO:0050908) | 2.77907446 |
| 139 | * synaptic transmission (GO:0007268) | 2.77016164 |
| 140 | positive regulation of dendritic spine development (GO:0060999) | 2.76755540 |
| 141 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 2.75923434 |
| 142 | regulation of vesicle fusion (GO:0031338) | 2.74802777 |
| 143 | cellular sodium ion homeostasis (GO:0006883) | 2.70885693 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.81921126 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.26261505 |
| 3 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.90293521 |
| 4 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.82933440 |
| 5 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.79620530 |
| 6 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.77830377 |
| 7 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.71107968 |
| 8 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.68103197 |
| 9 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.53125951 |
| 10 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.53125951 |
| 11 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.51084427 |
| 12 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.49435613 |
| 13 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.38164744 |
| 14 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.35403045 |
| 15 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.31485348 |
| 16 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.28566401 |
| 17 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.20896424 |
| 18 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.20395857 |
| 19 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.18974948 |
| 20 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.11897230 |
| 21 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.11695838 |
| 22 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.11207585 |
| 23 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.09772629 |
| 24 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.01877134 |
| 25 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.00530515 |
| 26 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 2.00496958 |
| 27 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.99224840 |
| 28 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.98166177 |
| 29 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.97666907 |
| 30 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.94663975 |
| 31 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.94301943 |
| 32 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.92992995 |
| 33 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.92909136 |
| 34 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.86912070 |
| 35 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.82643660 |
| 36 | VDR_22108803_ChIP-Seq_LS180_Human | 1.71343189 |
| 37 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.70065649 |
| 38 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.68347419 |
| 39 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.62909768 |
| 40 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.62013402 |
| 41 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.59242569 |
| 42 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.57480797 |
| 43 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.51838742 |
| 44 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.48391450 |
| 45 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.47506049 |
| 46 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.41649543 |
| 47 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.41630802 |
| 48 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.41314609 |
| 49 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.40511642 |
| 50 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.40511642 |
| 51 | * MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.39491966 |
| 52 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.37577793 |
| 53 | FUS_26573619_Chip-Seq_HEK293_Human | 1.37322807 |
| 54 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.36603867 |
| 55 | * PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.33394497 |
| 56 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.33139927 |
| 57 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.32738437 |
| 58 | AR_19668381_ChIP-Seq_PC3_Human | 1.31693284 |
| 59 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.30482858 |
| 60 | EWS_26573619_Chip-Seq_HEK293_Human | 1.29728851 |
| 61 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.28842233 |
| 62 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.28194861 |
| 63 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.25577311 |
| 64 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.23745397 |
| 65 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.23146164 |
| 66 | AR_25329375_ChIP-Seq_VCAP_Human | 1.22183606 |
| 67 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.22064684 |
| 68 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.21288774 |
| 69 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.19903772 |
| 70 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.19208959 |
| 71 | KDM2B_26808549_Chip-Seq_K562_Human | 1.17908514 |
| 72 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.17400138 |
| 73 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.17282506 |
| 74 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.16929873 |
| 75 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.14360513 |
| 76 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.14110802 |
| 77 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.13970048 |
| 78 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.13624918 |
| 79 | P300_19829295_ChIP-Seq_ESCs_Human | 1.11556173 |
| 80 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.11016149 |
| 81 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.10921943 |
| 82 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.10394281 |
| 83 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.10269710 |
| 84 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.09871248 |
| 85 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.08431382 |
| 86 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.08262449 |
| 87 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.07636823 |
| 88 | KDM2B_26808549_Chip-Seq_REH_Human | 1.07410243 |
| 89 | * TCF4_22108803_ChIP-Seq_LS180_Human | 1.07401489 |
| 90 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.06248736 |
| 91 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.05830329 |
| 92 | TP53_16413492_ChIP-PET_HCT116_Human | 1.05740179 |
| 93 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.05588216 |
| 94 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.04723018 |
| 95 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.04022391 |
| 96 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.03819170 |
| 97 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.03778373 |
| 98 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.02992475 |
| 99 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.02756431 |
| 100 | RXR_22108803_ChIP-Seq_LS180_Human | 1.02709525 |
| 101 | * SOX2_19829295_ChIP-Seq_ESCs_Human | 1.02657626 |
| 102 | * NANOG_19829295_ChIP-Seq_ESCs_Human | 1.02657626 |
| 103 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.01588691 |
| 104 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.01207111 |
| 105 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.01020396 |
| 106 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.00452890 |
| 107 | * TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.99564737 |
| 108 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.99198463 |
| 109 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.98389753 |
| 110 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.97940710 |
| 111 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.97253054 |
| 112 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.96727992 |
| 113 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.96695788 |
| 114 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.96353066 |
| 115 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.96353066 |
| 116 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 0.96288034 |
| 117 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.96090795 |
| 118 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.95306059 |
| 119 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.94591235 |
| 120 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.94392297 |
| 121 | * SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.93667741 |
| 122 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.93521858 |
| 123 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.93437709 |
| 124 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.92975088 |
| 125 | * RUNX2_22187159_ChIP-Seq_PCA_Human | 0.92688979 |
| 126 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.92523260 |
| 127 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.92491651 |
| 128 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.92139191 |
| 129 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.91286254 |
| 130 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.91147895 |
| 131 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.91058381 |
| 132 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.90721790 |
| 133 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.90503214 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.89585591 |
| 2 | MP0002822_catalepsy | 4.88461397 |
| 3 | MP0003880_abnormal_central_pattern | 4.01907928 |
| 4 | * MP0003635_abnormal_synaptic_transmissio | 4.01727373 |
| 5 | MP0004270_analgesia | 3.67128223 |
| 6 | MP0009046_muscle_twitch | 3.66443041 |
| 7 | MP0009745_abnormal_behavioral_response | 3.40020991 |
| 8 | MP0005423_abnormal_somatic_nervous | 3.12360344 |
| 9 | * MP0002063_abnormal_learning/memory/cond | 3.05486278 |
| 10 | MP0002064_seizures | 3.02504744 |
| 11 | MP0003718_maternal_effect | 2.98339500 |
| 12 | MP0001968_abnormal_touch/_nociception | 2.88909520 |
| 13 | MP0001486_abnormal_startle_reflex | 2.80583538 |
| 14 | MP0002272_abnormal_nervous_system | 2.78345222 |
| 15 | MP0002734_abnormal_mechanical_nocicepti | 2.75966932 |
| 16 | MP0002572_abnormal_emotion/affect_behav | 2.64705824 |
| 17 | MP0008569_lethality_at_weaning | 2.29592623 |
| 18 | MP0005646_abnormal_pituitary_gland | 2.21991595 |
| 19 | MP0002736_abnormal_nociception_after | 2.15417132 |
| 20 | MP0001501_abnormal_sleep_pattern | 2.13135581 |
| 21 | MP0002067_abnormal_sensory_capabilities | 2.08841217 |
| 22 | MP0001529_abnormal_vocalization | 2.00804875 |
| 23 | MP0005386_behavior/neurological_phenoty | 1.92996493 |
| 24 | MP0004924_abnormal_behavior | 1.92996493 |
| 25 | MP0001970_abnormal_pain_threshold | 1.92510060 |
| 26 | MP0001984_abnormal_olfaction | 1.91799978 |
| 27 | MP0001440_abnormal_grooming_behavior | 1.86166706 |
| 28 | MP0008789_abnormal_olfactory_epithelium | 1.83902716 |
| 29 | MP0002909_abnormal_adrenal_gland | 1.82672692 |
| 30 | MP0002733_abnormal_thermal_nociception | 1.82183358 |
| 31 | MP0004885_abnormal_endolymph | 1.79507661 |
| 32 | MP0002184_abnormal_innervation | 1.75135412 |
| 33 | MP0002735_abnormal_chemical_nociception | 1.71048951 |
| 34 | MP0002557_abnormal_social/conspecific_i | 1.69294945 |
| 35 | MP0004145_abnormal_muscle_electrophysio | 1.60936370 |
| 36 | MP0003890_abnormal_embryonic-extraembry | 1.60669946 |
| 37 | MP0003879_abnormal_hair_cell | 1.53863052 |
| 38 | MP0001986_abnormal_taste_sensitivity | 1.53176023 |
| 39 | MP0004811_abnormal_neuron_physiology | 1.52375341 |
| 40 | MP0005551_abnormal_eye_electrophysiolog | 1.51966290 |
| 41 | MP0000955_abnormal_spinal_cord | 1.50608925 |
| 42 | MP0002234_abnormal_pharynx_morphology | 1.48667800 |
| 43 | MP0003329_amyloid_beta_deposits | 1.46025221 |
| 44 | MP0001502_abnormal_circadian_rhythm | 1.44429367 |
| 45 | MP0003690_abnormal_glial_cell | 1.42772093 |
| 46 | MP0002066_abnormal_motor_capabilities/c | 1.40353345 |
| 47 | MP0000778_abnormal_nervous_system | 1.39207802 |
| 48 | MP0002882_abnormal_neuron_morphology | 1.37389446 |
| 49 | MP0004142_abnormal_muscle_tone | 1.34308890 |
| 50 | MP0003787_abnormal_imprinting | 1.31959519 |
| 51 | MP0003633_abnormal_nervous_system | 1.26190579 |
| 52 | MP0005167_abnormal_blood-brain_barrier | 1.24935443 |
| 53 | MP0003646_muscle_fatigue | 1.24298880 |
| 54 | MP0003121_genomic_imprinting | 1.20050945 |
| 55 | MP0005410_abnormal_fertilization | 1.18741431 |
| 56 | MP0001188_hyperpigmentation | 1.18494568 |
| 57 | MP0004147_increased_porphyrin_level | 1.17139218 |
| 58 | MP0001905_abnormal_dopamine_level | 1.15621153 |
| 59 | MP0003631_nervous_system_phenotype | 1.15184207 |
| 60 | MP0001177_atelectasis | 1.13863178 |
| 61 | MP0004858_abnormal_nervous_system | 1.12335765 |
| 62 | MP0005395_other_phenotype | 1.12234206 |
| 63 | MP0002229_neurodegeneration | 1.09290521 |
| 64 | MP0000569_abnormal_digit_pigmentation | 1.07730279 |
| 65 | MP0002653_abnormal_ependyma_morphology | 1.06793888 |
| 66 | MP0002152_abnormal_brain_morphology | 1.05896470 |
| 67 | MP0008872_abnormal_physiological_respon | 1.04423999 |
| 68 | MP0003632_abnormal_nervous_system | 1.03747214 |
| 69 | MP0002160_abnormal_reproductive_system | 1.03569163 |
| 70 | MP0008874_decreased_physiological_sensi | 0.98930246 |
| 71 | MP0002138_abnormal_hepatobiliary_system | 0.97433936 |
| 72 | MP0001929_abnormal_gametogenesis | 0.94704191 |
| 73 | MP0006276_abnormal_autonomic_nervous | 0.93303394 |
| 74 | MP0006072_abnormal_retinal_apoptosis | 0.92247164 |
| 75 | MP0009780_abnormal_chondrocyte_physiolo | 0.92023601 |
| 76 | MP0000920_abnormal_myelination | 0.91666061 |
| 77 | MP0000427_abnormal_hair_cycle | 0.89937932 |
| 78 | MP0004742_abnormal_vestibular_system | 0.89774288 |
| 79 | MP0001299_abnormal_eye_distance/ | 0.88777913 |
| 80 | MP0005409_darkened_coat_color | 0.88581844 |
| 81 | MP0003195_calcinosis | 0.88463710 |
| 82 | MP0002876_abnormal_thyroid_physiology | 0.88214065 |
| 83 | MP0002210_abnormal_sex_determination | 0.87735891 |
| 84 | MP0005394_taste/olfaction_phenotype | 0.85826338 |
| 85 | MP0005499_abnormal_olfactory_system | 0.85826338 |
| 86 | MP0003698_abnormal_male_reproductive | 0.85285339 |
| 87 | MP0002752_abnormal_somatic_nervous | 0.84566903 |
| 88 | MP0004085_abnormal_heartbeat | 0.84108249 |
| 89 | MP0008057_abnormal_DNA_replication | 0.83409789 |
| 90 | MP0003634_abnormal_glial_cell | 0.82854079 |
| 91 | MP0001485_abnormal_pinna_reflex | 0.82177345 |
| 92 | MP0003137_abnormal_impulse_conducting | 0.81436173 |
| 93 | MP0004215_abnormal_myocardial_fiber | 0.81313943 |
| 94 | MP0000751_myopathy | 0.80958789 |
| 95 | MP0002161_abnormal_fertility/fecundity | 0.80382520 |
| 96 | MP0003183_abnormal_peptide_metabolism | 0.80105007 |
| 97 | MP0002837_dystrophic_cardiac_calcinosis | 0.78329135 |
| 98 | MP0002069_abnormal_eating/drinking_beha | 0.78243868 |
| 99 | MP0003699_abnormal_female_reproductive | 0.77929515 |
| 100 | MP0002090_abnormal_vision | 0.75970721 |
| 101 | MP0000631_abnormal_neuroendocrine_gland | 0.75115065 |
| 102 | MP0001963_abnormal_hearing_physiology | 0.73582151 |
| 103 | MP0008877_abnormal_DNA_methylation | 0.72589080 |
| 104 | MP0003075_altered_response_to | 0.72066844 |
| 105 | MP0000653_abnormal_sex_gland | 0.71972189 |
| 106 | MP0010386_abnormal_urinary_bladder | 0.71797473 |
| 107 | MP0002638_abnormal_pupillary_reflex | 0.71266924 |
| 108 | MP0006292_abnormal_olfactory_placode | 0.68902199 |
| 109 | MP0008961_abnormal_basal_metabolism | 0.68178863 |
| 110 | MP0002102_abnormal_ear_morphology | 0.67720539 |
| 111 | MP0003136_yellow_coat_color | 0.66721594 |
| 112 | MP0003283_abnormal_digestive_organ | 0.65912008 |
| 113 | MP0005389_reproductive_system_phenotype | 0.65557552 |
| 114 | MP0005253_abnormal_eye_physiology | 0.64422753 |
| 115 | MP0005645_abnormal_hypothalamus_physiol | 0.63373172 |
| 116 | MP0004233_abnormal_muscle_weight | 0.63296307 |
| 117 | MP0004043_abnormal_pH_regulation | 0.59632262 |
| 118 | MP0000639_abnormal_adrenal_gland | 0.58910679 |
| 119 | MP0003123_paternal_imprinting | 0.58760059 |
| 120 | MP0003861_abnormal_nervous_system | 0.52945066 |
| 121 | MP0003122_maternal_imprinting | 0.52155879 |
| 122 | MP0005535_abnormal_body_temperature | 0.51123209 |
| 123 | MP0000013_abnormal_adipose_tissue | 0.50728125 |
| 124 | MP0010769_abnormal_survival | 0.49285460 |
| 125 | MP0003950_abnormal_plasma_membrane | 0.48892919 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.37344106 |
| 2 | Myokymia (HP:0002411) | 7.23072916 |
| 3 | Focal seizures (HP:0007359) | 5.32084794 |
| 4 | Action tremor (HP:0002345) | 5.27118623 |
| 5 | Progressive cerebellar ataxia (HP:0002073) | 4.63108376 |
| 6 | Visual hallucinations (HP:0002367) | 4.34833460 |
| 7 | Febrile seizures (HP:0002373) | 4.34687793 |
| 8 | Atonic seizures (HP:0010819) | 4.10453403 |
| 9 | Gaze-evoked nystagmus (HP:0000640) | 4.06743396 |
| 10 | Epileptic encephalopathy (HP:0200134) | 3.83886916 |
| 11 | Dysdiadochokinesis (HP:0002075) | 3.80924063 |
| 12 | Supernumerary spleens (HP:0009799) | 3.80394983 |
| 13 | Absence seizures (HP:0002121) | 3.68358830 |
| 14 | Generalized tonic-clonic seizures (HP:0002069) | 3.55954561 |
| 15 | Dysmetric saccades (HP:0000641) | 3.52073665 |
| 16 | Abnormality of the labia minora (HP:0012880) | 3.47987367 |
| 17 | Annular pancreas (HP:0001734) | 3.40488015 |
| 18 | Torticollis (HP:0000473) | 3.33552279 |
| 19 | Dysmetria (HP:0001310) | 3.31008685 |
| 20 | Broad-based gait (HP:0002136) | 3.29316308 |
| 21 | Dialeptic seizures (HP:0011146) | 3.24478291 |
| 22 | Scanning speech (HP:0002168) | 3.24311769 |
| 23 | Poor eye contact (HP:0000817) | 3.24193254 |
| 24 | Genetic anticipation (HP:0003743) | 3.22681440 |
| 25 | Truncal ataxia (HP:0002078) | 3.14962203 |
| 26 | Urinary bladder sphincter dysfunction (HP:0002839) | 3.13571425 |
| 27 | Mutism (HP:0002300) | 3.11170588 |
| 28 | Depression (HP:0000716) | 3.11010945 |
| 29 | Impaired smooth pursuit (HP:0007772) | 3.10095161 |
| 30 | Hemiplegia (HP:0002301) | 3.09253872 |
| 31 | Ankle clonus (HP:0011448) | 3.08836865 |
| 32 | Postural instability (HP:0002172) | 2.99110527 |
| 33 | Intention tremor (HP:0002080) | 2.98027462 |
| 34 | Hyperventilation (HP:0002883) | 2.96629402 |
| 35 | Ventricular fibrillation (HP:0001663) | 2.93934885 |
| 36 | Abnormal eating behavior (HP:0100738) | 2.91119390 |
| 37 | Impaired social interactions (HP:0000735) | 2.90320234 |
| 38 | Abnormal social behavior (HP:0012433) | 2.90320234 |
| 39 | Supranuclear gaze palsy (HP:0000605) | 2.89658612 |
| 40 | Anxiety (HP:0000739) | 2.88442408 |
| 41 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.86875222 |
| 42 | Fair hair (HP:0002286) | 2.86555200 |
| 43 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.84638250 |
| 44 | Focal dystonia (HP:0004373) | 2.73862994 |
| 45 | Tetraplegia (HP:0002445) | 2.70205453 |
| 46 | Hemiparesis (HP:0001269) | 2.68543774 |
| 47 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.62177509 |
| 48 | Craniofacial dystonia (HP:0012179) | 2.62013908 |
| 49 | Hypoplasia of the fovea (HP:0007750) | 2.61485507 |
| 50 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.61485507 |
| 51 | Diplopia (HP:0000651) | 2.53398928 |
| 52 | Abnormality of binocular vision (HP:0011514) | 2.53398928 |
| 53 | Generalized hypopigmentation of hair (HP:0011358) | 2.47720165 |
| 54 | Status epilepticus (HP:0002133) | 2.46816623 |
| 55 | Pointed chin (HP:0000307) | 2.45236721 |
| 56 | Fetal akinesia sequence (HP:0001989) | 2.43850304 |
| 57 | Central scotoma (HP:0000603) | 2.43241952 |
| 58 | Aplasia involving bones of the extremities (HP:0009825) | 2.40744628 |
| 59 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.40744628 |
| 60 | Aplasia of the phalanges of the hand (HP:0009802) | 2.40744628 |
| 61 | Bundle branch block (HP:0011710) | 2.37969671 |
| 62 | Abnormality of saccadic eye movements (HP:0000570) | 2.35431328 |
| 63 | Male infertility (HP:0003251) | 2.35266177 |
| 64 | Abnormality of the fovea (HP:0000493) | 2.32805043 |
| 65 | Prolonged QT interval (HP:0001657) | 2.32325756 |
| 66 | Short tibia (HP:0005736) | 2.31393676 |
| 67 | Abnormality of midbrain morphology (HP:0002418) | 2.30958094 |
| 68 | Molar tooth sign on MRI (HP:0002419) | 2.30958094 |
| 69 | Spastic gait (HP:0002064) | 2.30140043 |
| 70 | Increased circulating renin level (HP:0000848) | 2.27748428 |
| 71 | Stereotypic behavior (HP:0000733) | 2.27336781 |
| 72 | Abnormality of macular pigmentation (HP:0008002) | 2.26790701 |
| 73 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.22664372 |
| 74 | Atrioventricular block (HP:0001678) | 2.20232525 |
| 75 | Hypsarrhythmia (HP:0002521) | 2.17227634 |
| 76 | Abnormality of the lower motor neuron (HP:0002366) | 2.16278199 |
| 77 | Abnormality of abdominal situs (HP:0011620) | 2.15922812 |
| 78 | Abdominal situs inversus (HP:0003363) | 2.15922812 |
| 79 | Medial flaring of the eyebrow (HP:0010747) | 2.15664452 |
| 80 | Incomplete penetrance (HP:0003829) | 2.14127884 |
| 81 | Urinary urgency (HP:0000012) | 2.14026385 |
| 82 | Heart block (HP:0012722) | 2.13874794 |
| 83 | Anterior segment dysgenesis (HP:0007700) | 2.12007103 |
| 84 | Attenuation of retinal blood vessels (HP:0007843) | 2.11695647 |
| 85 | Impaired vibratory sensation (HP:0002495) | 2.11611607 |
| 86 | Megalencephaly (HP:0001355) | 2.09575159 |
| 87 | Abnormal EKG (HP:0003115) | 2.09480828 |
| 88 | Clonus (HP:0002169) | 2.09305327 |
| 89 | Resting tremor (HP:0002322) | 2.07850227 |
| 90 | Inability to walk (HP:0002540) | 2.07648242 |
| 91 | Facial hemangioma (HP:0000329) | 2.06645802 |
| 92 | Absent speech (HP:0001344) | 2.06468691 |
| 93 | Bradykinesia (HP:0002067) | 2.05716439 |
| 94 | Optic nerve hypoplasia (HP:0000609) | 2.05163225 |
| 95 | Horizontal nystagmus (HP:0000666) | 2.03990156 |
| 96 | Gait imbalance (HP:0002141) | 2.02977107 |
| 97 | Pancreatic cysts (HP:0001737) | 2.01913659 |
| 98 | Type II lissencephaly (HP:0007260) | 1.99398316 |
| 99 | Impulsivity (HP:0100710) | 1.98930601 |
| 100 | Papilledema (HP:0001085) | 1.98609860 |
| 101 | Neuronal loss in central nervous system (HP:0002529) | 1.97463165 |
| 102 | Congenital sensorineural hearing impairment (HP:0008527) | 1.94814456 |
| 103 | Progressive inability to walk (HP:0002505) | 1.93296952 |
| 104 | Protruding tongue (HP:0010808) | 1.93149114 |
| 105 | Septo-optic dysplasia (HP:0100842) | 1.93015460 |
| 106 | Pancreatic fibrosis (HP:0100732) | 1.91741802 |
| 107 | Enlarged penis (HP:0000040) | 1.90755151 |
| 108 | Abnormal atrioventricular conduction (HP:0005150) | 1.90393874 |
| 109 | Cerebral hypomyelination (HP:0006808) | 1.90319994 |
| 110 | Insomnia (HP:0100785) | 1.88860585 |
| 111 | Absent septum pellucidum (HP:0001331) | 1.88071197 |
| 112 | Gait ataxia (HP:0002066) | 1.87844790 |
| 113 | Decreased central vision (HP:0007663) | 1.87689382 |
| 114 | Postural tremor (HP:0002174) | 1.87507706 |
| 115 | Dyskinesia (HP:0100660) | 1.86903268 |
| 116 | Drooling (HP:0002307) | 1.83578694 |
| 117 | Excessive salivation (HP:0003781) | 1.83578694 |
| 118 | Peripheral hypomyelination (HP:0007182) | 1.81839629 |
| 119 | Apathy (HP:0000741) | 1.81829719 |
| 120 | Limb dystonia (HP:0002451) | 1.81245829 |
| 121 | Termporal pattern (HP:0011008) | 1.80789450 |
| 122 | Insidious onset (HP:0003587) | 1.80789450 |
| 123 | Papillary thyroid carcinoma (HP:0002895) | 1.79147882 |
| 124 | Oligodactyly (HP:0012165) | 1.78908321 |
| 125 | Spinal canal stenosis (HP:0003416) | 1.78815878 |
| 126 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.78470657 |
| 127 | Lower limb muscle weakness (HP:0007340) | 1.77344858 |
| 128 | Abnormality of the renal cortex (HP:0011035) | 1.77329448 |
| 129 | Abnormality of the corticospinal tract (HP:0002492) | 1.77200144 |
| 130 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.76441062 |
| 131 | Congenital stationary night blindness (HP:0007642) | 1.75803436 |
| 132 | CNS hypomyelination (HP:0003429) | 1.75120602 |
| 133 | Limb ataxia (HP:0002070) | 1.74004420 |
| 134 | Amblyopia (HP:0000646) | 1.73994532 |
| 135 | Lower limb asymmetry (HP:0100559) | 1.73940879 |
| 136 | Decreased circulating renin level (HP:0003351) | 1.73844804 |
| 137 | Nephronophthisis (HP:0000090) | 1.73149345 |
| 138 | Neurofibrillary tangles (HP:0002185) | 1.73123734 |
| 139 | Median cleft lip (HP:0000161) | 1.72547480 |
| 140 | Onion bulb formation (HP:0003383) | 1.72061059 |
| 141 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.70793142 |
| 142 | Gonadotropin excess (HP:0000837) | 1.68519097 |
| 143 | Scotoma (HP:0000575) | 1.67538048 |
| 144 | Generalized myoclonic seizures (HP:0002123) | 1.67394186 |
| 145 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.66932079 |
| 146 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.66932079 |
| 147 | Oligodactyly (hands) (HP:0001180) | 1.66022959 |
| 148 | Obstructive sleep apnea (HP:0002870) | 1.65117496 |
| 149 | EEG with generalized epileptiform discharges (HP:0011198) | 1.65094172 |
| 150 | Epileptiform EEG discharges (HP:0011182) | 1.63112622 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 4.57979226 |
| 2 | MAP3K9 | 3.89393100 |
| 3 | NTRK3 | 3.50794646 |
| 4 | FRK | 3.43648020 |
| 5 | KSR2 | 2.95342650 |
| 6 | MAP3K4 | 2.55744728 |
| 7 | PAK6 | 2.54384201 |
| 8 | PRKD3 | 2.38076313 |
| 9 | TNIK | 2.33590483 |
| 10 | CAMKK1 | 2.20980716 |
| 11 | STK38 | 2.20063487 |
| 12 | MAP2K7 | 2.13818038 |
| 13 | NTRK2 | 2.11741684 |
| 14 | MINK1 | 2.10307838 |
| 15 | TAOK1 | 1.97844927 |
| 16 | MAP3K13 | 1.97671276 |
| 17 | CAMKK2 | 1.89404355 |
| 18 | RIPK4 | 1.74431017 |
| 19 | MARK1 | 1.73538375 |
| 20 | MUSK | 1.68651994 |
| 21 | PINK1 | 1.66130395 |
| 22 | DAPK2 | 1.64984900 |
| 23 | ARAF | 1.64791885 |
| 24 | NTRK1 | 1.62679423 |
| 25 | MAP2K4 | 1.61256588 |
| 26 | KSR1 | 1.59176489 |
| 27 | LATS2 | 1.57501657 |
| 28 | STK39 | 1.51887639 |
| 29 | BMPR1B | 1.50871641 |
| 30 | TAOK3 | 1.50806444 |
| 31 | SGK494 | 1.40892740 |
| 32 | SGK223 | 1.40892740 |
| 33 | SGK2 | 1.40666761 |
| 34 | RIPK1 | 1.40446761 |
| 35 | WNK3 | 1.37927299 |
| 36 | ZAK | 1.36768876 |
| 37 | RAF1 | 1.35609061 |
| 38 | TYRO3 | 1.35562968 |
| 39 | CDK5 | 1.27143594 |
| 40 | ACVR1B | 1.25441144 |
| 41 | MAP3K6 | 1.25145857 |
| 42 | MAPK13 | 1.24240673 |
| 43 | SGK3 | 1.20711575 |
| 44 | FES | 1.18947357 |
| 45 | WNK1 | 1.18074347 |
| 46 | PKN1 | 1.06718233 |
| 47 | TRIM28 | 1.04956474 |
| 48 | NEK6 | 1.02163858 |
| 49 | NUAK1 | 1.00699335 |
| 50 | PRKCG | 0.99185028 |
| 51 | GRK1 | 0.98262461 |
| 52 | PRPF4B | 0.97995068 |
| 53 | PRKCH | 0.95681556 |
| 54 | BRSK1 | 0.94028169 |
| 55 | MAP3K12 | 0.93933418 |
| 56 | INSRR | 0.90374581 |
| 57 | CAMK2A | 0.89399514 |
| 58 | NEK1 | 0.89140728 |
| 59 | RET | 0.88926770 |
| 60 | STK11 | 0.88775155 |
| 61 | BRAF | 0.86605469 |
| 62 | MARK2 | 0.86566805 |
| 63 | OBSCN | 0.85120718 |
| 64 | WNK4 | 0.82696600 |
| 65 | LMTK2 | 0.82304204 |
| 66 | SGK1 | 0.82189411 |
| 67 | BMPR2 | 0.82142073 |
| 68 | CDK15 | 0.82109580 |
| 69 | CDK18 | 0.80939145 |
| 70 | ADRBK2 | 0.80906123 |
| 71 | MOS | 0.79132835 |
| 72 | PHKG1 | 0.78391548 |
| 73 | PHKG2 | 0.78391548 |
| 74 | TLK1 | 0.77610851 |
| 75 | PRKD2 | 0.76982040 |
| 76 | MAP3K2 | 0.76510497 |
| 77 | TNK2 | 0.74847203 |
| 78 | PRKCI | 0.74568147 |
| 79 | GRK5 | 0.73616220 |
| 80 | CAMK1 | 0.71606195 |
| 81 | MAPK10 | 0.70859831 |
| 82 | CDK11A | 0.70445821 |
| 83 | SIK2 | 0.70427516 |
| 84 | CAMK2B | 0.70280498 |
| 85 | CDK14 | 0.69198180 |
| 86 | MAPKAPK5 | 0.67783129 |
| 87 | CDK9 | 0.67618995 |
| 88 | CAMK2G | 0.66963111 |
| 89 | PLK2 | 0.64944347 |
| 90 | CSNK1D | 0.64646811 |
| 91 | PRKG1 | 0.63551676 |
| 92 | MAP4K2 | 0.63024318 |
| 93 | STK38L | 0.62423032 |
| 94 | CAMK2D | 0.61061883 |
| 95 | LATS1 | 0.60906238 |
| 96 | STK24 | 0.60068392 |
| 97 | MAP3K1 | 0.59928271 |
| 98 | DMPK | 0.58467110 |
| 99 | CCNB1 | 0.58267703 |
| 100 | DAPK1 | 0.57580331 |
| 101 | FGFR2 | 0.57415299 |
| 102 | PDK1 | 0.57256195 |
| 103 | CSNK1G1 | 0.57202690 |
| 104 | RPS6KA3 | 0.56925166 |
| 105 | ALK | 0.56606294 |
| 106 | MKNK2 | 0.56032227 |
| 107 | PRKCE | 0.55943517 |
| 108 | PDPK1 | 0.55469335 |
| 109 | ERBB4 | 0.54108649 |
| 110 | UHMK1 | 0.53141958 |
| 111 | MET | 0.53097261 |
| 112 | AURKA | 0.53094497 |
| 113 | CDC42BPA | 0.50461082 |
| 114 | CSNK1G2 | 0.49893733 |
| 115 | CDK3 | 0.49289577 |
| 116 | TIE1 | 0.48555928 |
| 117 | CDK19 | 0.48542136 |
| 118 | CSNK1G3 | 0.48075878 |
| 119 | EIF2AK3 | 0.47499781 |
| 120 | PLK3 | 0.46222516 |
| 121 | ROCK2 | 0.46060333 |
| 122 | DYRK1A | 0.45391118 |
| 123 | PRKAA1 | 0.43019470 |
| 124 | CASK | 0.40046285 |
| 125 | PRKCA | 0.38733668 |
| 126 | ROCK1 | 0.36562840 |
| 127 | CAMK4 | 0.36274106 |
| 128 | PRKCZ | 0.36144864 |
| 129 | PAK3 | 0.34102530 |
| 130 | CSNK1A1 | 0.32799046 |
| 131 | OXSR1 | 0.30425489 |
| 132 | FYN | 0.29775894 |
| 133 | PRKACA | 0.29705729 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.61777924 |
| 2 | Olfactory transduction_Homo sapiens_hsa04740 | 3.07288702 |
| 3 | GABAergic synapse_Homo sapiens_hsa04727 | 2.86978452 |
| 4 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.72922737 |
| 5 | Morphine addiction_Homo sapiens_hsa05032 | 2.67142947 |
| 6 | * Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.63488342 |
| 7 | Circadian entrainment_Homo sapiens_hsa04713 | 2.61384119 |
| 8 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.58591066 |
| 9 | Long-term potentiation_Homo sapiens_hsa04720 | 2.48795877 |
| 10 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.30620427 |
| 11 | Salivary secretion_Homo sapiens_hsa04970 | 2.12957274 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.10604881 |
| 13 | Cocaine addiction_Homo sapiens_hsa05030 | 2.00702696 |
| 14 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.94462130 |
| 15 | Insulin secretion_Homo sapiens_hsa04911 | 1.91475834 |
| 16 | Long-term depression_Homo sapiens_hsa04730 | 1.86917255 |
| 17 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.85696459 |
| 18 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.85496967 |
| 19 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.77135098 |
| 20 | Taste transduction_Homo sapiens_hsa04742 | 1.73186359 |
| 21 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.72841962 |
| 22 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.65901869 |
| 23 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.63568624 |
| 24 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.62050396 |
| 25 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.61362075 |
| 26 | Renin secretion_Homo sapiens_hsa04924 | 1.57781481 |
| 27 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.56190521 |
| 28 | Basal transcription factors_Homo sapiens_hsa03022 | 1.53685602 |
| 29 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.53308387 |
| 30 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.51821952 |
| 31 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.43119425 |
| 32 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.40661397 |
| 33 | Gap junction_Homo sapiens_hsa04540 | 1.39912131 |
| 34 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.29218971 |
| 35 | Circadian rhythm_Homo sapiens_hsa04710 | 1.28058563 |
| 36 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.27015727 |
| 37 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.22312503 |
| 38 | Phototransduction_Homo sapiens_hsa04744 | 1.11675848 |
| 39 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.09386524 |
| 40 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.09230830 |
| 41 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.07745277 |
| 42 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.05547808 |
| 43 | ABC transporters_Homo sapiens_hsa02010 | 1.05095770 |
| 44 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.04860738 |
| 45 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.04117650 |
| 46 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.00911299 |
| 47 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.99396993 |
| 48 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.96140074 |
| 49 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.94604850 |
| 50 | Glioma_Homo sapiens_hsa05214 | 0.94269941 |
| 51 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.93245214 |
| 52 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.91275876 |
| 53 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.91052695 |
| 54 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.91024979 |
| 55 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.90919777 |
| 56 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.90283132 |
| 57 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.90247396 |
| 58 | Melanogenesis_Homo sapiens_hsa04916 | 0.86089788 |
| 59 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.84667850 |
| 60 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.83102216 |
| 61 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.79775818 |
| 62 | RNA degradation_Homo sapiens_hsa03018 | 0.78033016 |
| 63 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.77196462 |
| 64 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.76829499 |
| 65 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.75121421 |
| 66 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.72055246 |
| 67 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.71420156 |
| 68 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.68412641 |
| 69 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.67923358 |
| 70 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.67727015 |
| 71 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.67261896 |
| 72 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.66935386 |
| 73 | Axon guidance_Homo sapiens_hsa04360 | 0.64372081 |
| 74 | Bile secretion_Homo sapiens_hsa04976 | 0.62902760 |
| 75 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.61814344 |
| 76 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.61625973 |
| 77 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.60898294 |
| 78 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.60893391 |
| 79 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.59823584 |
| 80 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.56017819 |
| 81 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.55872458 |
| 82 | Histidine metabolism_Homo sapiens_hsa00340 | 0.55687086 |
| 83 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.55154811 |
| 84 | Endometrial cancer_Homo sapiens_hsa05213 | 0.54742915 |
| 85 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.54697632 |
| 86 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.54325585 |
| 87 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.53999707 |
| 88 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.53734099 |
| 89 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.53416232 |
| 90 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.53065835 |
| 91 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.52784922 |
| 92 | Alcoholism_Homo sapiens_hsa05034 | 0.50933549 |
| 93 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.50350144 |
| 94 | Mineral absorption_Homo sapiens_hsa04978 | 0.49043616 |
| 95 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.48981784 |
| 96 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.48624500 |
| 97 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.47404587 |
| 98 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.46368783 |
| 99 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.46343389 |
| 100 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.45281241 |
| 101 | Homologous recombination_Homo sapiens_hsa03440 | 0.45038250 |
| 102 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.43565993 |
| 103 | Endocytosis_Homo sapiens_hsa04144 | 0.43058810 |
| 104 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.41975332 |
| 105 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.41569818 |
| 106 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.40740315 |
| 107 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.40440765 |
| 108 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.40029670 |
| 109 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.39077637 |
| 110 | Colorectal cancer_Homo sapiens_hsa05210 | 0.38208012 |
| 111 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.37266082 |
| 112 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.36923403 |
| 113 | Cell cycle_Homo sapiens_hsa04110 | 0.36414730 |
| 114 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.35204946 |
| 115 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.33984752 |
| 116 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.32434796 |
| 117 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.32238418 |
| 118 | Platelet activation_Homo sapiens_hsa04611 | 0.30216423 |
| 119 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.29742069 |
| 120 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.28579738 |
| 121 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.28161609 |
| 122 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.27179180 |
| 123 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.26192319 |
| 124 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.25033957 |
| 125 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.24763779 |
| 126 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.24507257 |
| 127 | Alzheimers disease_Homo sapiens_hsa05010 | 0.24011751 |
| 128 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.22637882 |

