UNC13D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.36352257
2positive regulation of gamma-delta T cell activation (GO:0046645)6.20391312
3negative regulation of cell killing (GO:0031342)5.68466176
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.68466176
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.43943388
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.36872902
7antigen processing and presentation of endogenous antigen (GO:0019883)5.26488183
8DNA deamination (GO:0045006)5.13647973
9neutrophil activation involved in immune response (GO:0002283)5.08175435
10positive regulation by symbiont of host defense response (GO:0052509)4.97943155
11modulation by symbiont of host defense response (GO:0052031)4.97943155
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.97943155
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.97943155
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.97943155
15modulation by symbiont of host immune response (GO:0052553)4.97943155
16ribosomal small subunit assembly (GO:0000028)4.93664165
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.91781739
18negative regulation of erythrocyte differentiation (GO:0045647)4.89673813
19maturation of SSU-rRNA (GO:0030490)4.76203280
20response to peptidoglycan (GO:0032494)4.64753049
21regulation of B cell receptor signaling pathway (GO:0050855)4.59710836
22regulation of gamma-delta T cell activation (GO:0046643)4.53420506
23detection of other organism (GO:0098543)4.48450961
24leukocyte aggregation (GO:0070486)4.47583604
25detection of bacterium (GO:0016045)4.44860880
26viral transcription (GO:0019083)4.40218059
27proteasome assembly (GO:0043248)4.31671677
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.31653802
29regulation of gamma-delta T cell differentiation (GO:0045586)4.31145949
30translational termination (GO:0006415)4.24487284
31telomere maintenance via semi-conservative replication (GO:0032201)4.16558666
32positive regulation of B cell differentiation (GO:0045579)4.16375429
33ribonucleoprotein complex biogenesis (GO:0022613)4.13754997
34cellular extravasation (GO:0045123)4.04260261
35transcription elongation from RNA polymerase III promoter (GO:0006385)4.03382467
36termination of RNA polymerase III transcription (GO:0006386)4.03382467
37ribosomal large subunit biogenesis (GO:0042273)3.97292305
38macrophage activation involved in immune response (GO:0002281)3.97155898
39response to interleukin-15 (GO:0070672)3.96914268
40DNA strand elongation involved in DNA replication (GO:0006271)3.90768005
41negative regulation of lymphocyte mediated immunity (GO:0002707)3.85036638
42neutrophil activation (GO:0042119)3.84542647
43ribosome assembly (GO:0042255)3.84464998
44regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.81442445
45negative regulation of interleukin-12 production (GO:0032695)3.80385320
46immunoglobulin mediated immune response (GO:0016064)3.79721625
47negative thymic T cell selection (GO:0045060)3.79622127
48response to muramyl dipeptide (GO:0032495)3.78602582
49DNA strand elongation (GO:0022616)3.74683640
50translational elongation (GO:0006414)3.70046474
51respiratory burst (GO:0045730)3.69771606
52SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.67415254
53DNA replication initiation (GO:0006270)3.64987333
54negative T cell selection (GO:0043383)3.64568437
55cotranslational protein targeting to membrane (GO:0006613)3.63517127
56regulation of B cell differentiation (GO:0045577)3.63461709
57telomere maintenance via recombination (GO:0000722)3.62992763
58negative regulation of T cell mediated immunity (GO:0002710)3.62090097
59detection of external biotic stimulus (GO:0098581)3.59957036
60B cell receptor signaling pathway (GO:0050853)3.59337482
61protein targeting to ER (GO:0045047)3.58376562
62rRNA processing (GO:0006364)3.57603315
63rRNA modification (GO:0000154)3.57022763
64positive thymic T cell selection (GO:0045059)3.53304583
657-methylguanosine mRNA capping (GO:0006370)3.53243109
66translational initiation (GO:0006413)3.51971347
67negative regulation of leukocyte mediated immunity (GO:0002704)3.51392748
68response to host immune response (GO:0052572)3.50968422
69response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.50968422
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.50063416
71granulocyte activation (GO:0036230)3.49972287
72rRNA metabolic process (GO:0016072)3.47590378
73regulation of interferon-beta biosynthetic process (GO:0045357)3.47127327
747-methylguanosine RNA capping (GO:0009452)3.46296071
75RNA capping (GO:0036260)3.46296071
76regulation of nuclear cell cycle DNA replication (GO:0033262)3.45632699
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.44798221
78tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.44798221
79establishment of integrated proviral latency (GO:0075713)3.44378183
80nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.43704579
81ribosome biogenesis (GO:0042254)3.40910170
82pseudouridine synthesis (GO:0001522)3.40571658
83DNA damage response, detection of DNA damage (GO:0042769)3.40531044
84myeloid cell activation involved in immune response (GO:0002275)3.40150326
85establishment of protein localization to endoplasmic reticulum (GO:0072599)3.38467871
86protein localization to endoplasmic reticulum (GO:0070972)3.37780734
87* regulation of mast cell degranulation (GO:0043304)3.36716946
88tolerance induction (GO:0002507)3.36005315
89positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.35349702
90cellular protein complex disassembly (GO:0043624)3.35296127
91transcription-coupled nucleotide-excision repair (GO:0006283)3.34532113
92viral life cycle (GO:0019058)3.32047996
93nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.30662077
94cellular component biogenesis (GO:0044085)3.30367599
95response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.29697568
96response to host (GO:0075136)3.29697568
97response to host defenses (GO:0052200)3.29697568
98leukocyte migration involved in inflammatory response (GO:0002523)3.29639192
99termination of RNA polymerase I transcription (GO:0006363)3.27123219
100telomere maintenance via telomere lengthening (GO:0010833)3.25178573
101negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24522338
102translation (GO:0006412)3.24092899
103transcription elongation from RNA polymerase I promoter (GO:0006362)3.21065078
104negative regulation of phagocytosis (GO:0050765)3.20701953
105spliceosomal snRNP assembly (GO:0000387)3.19917593
106positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.19871295
107mitotic recombination (GO:0006312)3.19757630
108cellular response to type I interferon (GO:0071357)3.19186996
109type I interferon signaling pathway (GO:0060337)3.19186996
110response to type I interferon (GO:0034340)3.18792758
111positive regulation of granulocyte differentiation (GO:0030854)3.17703712
112thymic T cell selection (GO:0045061)3.17690377
113T cell selection (GO:0045058)3.17182130
114transcription from RNA polymerase I promoter (GO:0006360)3.17158105
115DNA replication checkpoint (GO:0000076)3.16632263
116* regulation of myeloid leukocyte mediated immunity (GO:0002886)3.16326450
117positive regulation of mast cell activation (GO:0033005)3.15519933
118detection of biotic stimulus (GO:0009595)3.12173750
119T cell migration (GO:0072678)3.10485744
120deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.09878408
121positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.09775933
122negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.09487916
123* regulation of leukocyte degranulation (GO:0043300)3.06693048
124CENP-A containing nucleosome assembly (GO:0034080)3.05818891
125signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05687912
126signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05687912
127signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05687912
128defense response to protozoan (GO:0042832)3.04097706
129positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.03960812
130* regulation of mast cell activation involved in immune response (GO:0033006)3.03753841
131deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.03513869
132spliceosomal complex assembly (GO:0000245)3.02766328
133positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01680290
134regulation of T cell tolerance induction (GO:0002664)3.01615062
135detection of molecule of bacterial origin (GO:0032490)3.01292866
136antigen processing and presentation via MHC class Ib (GO:0002475)3.00272271
137B cell mediated immunity (GO:0019724)3.00030970
138response to protozoan (GO:0001562)3.00014896
139DNA-dependent DNA replication (GO:0006261)2.99275395
140regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98807622
141cellular response to interleukin-15 (GO:0071350)2.98570101
142nucleotide-excision repair, DNA gap filling (GO:0006297)2.98538530
143tRNA methylation (GO:0030488)2.97696271
144negative regulation of ligase activity (GO:0051352)2.97212945
145negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97212945
146DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.96051844
147signal transduction involved in DNA damage checkpoint (GO:0072422)2.95835743
148signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95835743
149regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.94720587
150regulation of natural killer cell mediated immunity (GO:0002715)2.94720587
151negative regulation of innate immune response (GO:0045824)2.94444836
152lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94395930
153regulation of tolerance induction (GO:0002643)2.93463042
154signal transduction involved in cell cycle checkpoint (GO:0072395)2.93089251
155regulation of alpha-beta T cell proliferation (GO:0046640)2.93053056
156intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92858502
157signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92858502
158positive T cell selection (GO:0043368)2.92822820
159* leukocyte degranulation (GO:0043299)2.92097081
160anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91664219
161protein complex disassembly (GO:0043241)2.91291735
162microglial cell activation (GO:0001774)2.90081600
163deoxyribonucleotide biosynthetic process (GO:0009263)2.89994849
164formation of translation preinitiation complex (GO:0001731)2.89483144
165antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.89464151
166mitochondrial DNA replication (GO:0006264)2.88161823
167megakaryocyte development (GO:0035855)2.87869838
168chromatin remodeling at centromere (GO:0031055)2.87410706
169establishment of viral latency (GO:0019043)2.85883528
170RNA methylation (GO:0001510)2.85797627
171macrophage activation (GO:0042116)2.85700276
172negative regulation of cytokine production involved in immune response (GO:0002719)2.84579626
173negative regulation of interleukin-6 production (GO:0032715)2.84134185
174ncRNA processing (GO:0034470)2.83229636
175deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.83196467
176regulation of mitochondrial translation (GO:0070129)2.82629568
177regulation of dendritic cell antigen processing and presentation (GO:0002604)2.82608054
178interferon-gamma-mediated signaling pathway (GO:0060333)2.82479161
179nuclear-transcribed mRNA catabolic process (GO:0000956)2.81559502
180regulation of cellular amino acid metabolic process (GO:0006521)2.79954392
181neutrophil mediated immunity (GO:0002446)2.79758135
182regulation of T cell mediated cytotoxicity (GO:0001914)2.79138717
183regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77900761
184positive regulation of mast cell degranulation (GO:0043306)2.77726467
185positive regulation of mast cell activation involved in immune response (GO:0033008)2.77726467
186* regulation of mast cell activation (GO:0033003)2.76621165
187positive regulation of T cell mediated cytotoxicity (GO:0001916)2.76129311
188nucleobase biosynthetic process (GO:0046112)2.75847281
189macromolecular complex disassembly (GO:0032984)2.75622313
190T cell homeostasis (GO:0043029)2.75277748
191antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.74556294
192RNA destabilization (GO:0050779)2.73558457
193rRNA methylation (GO:0031167)2.72110316
194maturation of 5.8S rRNA (GO:0000460)2.70611695
195ncRNA metabolic process (GO:0034660)2.69464538
196DNA-templated transcription, termination (GO:0006353)2.68562426
197transcription initiation from RNA polymerase I promoter (GO:0006361)2.67944192
198mRNA catabolic process (GO:0006402)2.67229998
199positive regulation of Cdc42 GTPase activity (GO:0043089)2.62893551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.35636218
2EST1_17652178_ChIP-ChIP_JURKAT_Human3.99086759
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.96185418
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.92784651
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.83537749
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.45346007
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.35779463
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.35323643
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.25525449
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.19593589
11MYC_22102868_ChIP-Seq_BL_Human3.09996843
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06757793
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.05210002
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.95944911
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87713214
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.87037017
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77118332
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.75446894
19VDR_23849224_ChIP-Seq_CD4+_Human2.71655414
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71570228
21VDR_24763502_ChIP-Seq_THP-1_Human2.71285501
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59545351
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54755103
24* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53877307
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53627975
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52318926
27* MAF_26560356_Chip-Seq_TH1_Human2.52045847
28EGR1_19374776_ChIP-ChIP_THP-1_Human2.40140682
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36950731
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31947279
31* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31523227
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.31456224
33UTX_26944678_Chip-Seq_JUKART_Human2.30737454
34MYB_21317192_ChIP-Seq_ERMYB_Mouse2.30523166
35SPI1_23127762_ChIP-Seq_K562_Human2.29907419
36RUNX1_22412390_ChIP-Seq_EML_Mouse2.27620532
37XRN2_22483619_ChIP-Seq_HELA_Human2.24039386
38IRF8_27001747_Chip-Seq_BMDM_Mouse2.22805112
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.22254010
40* TCF7_22412390_ChIP-Seq_EML_Mouse2.20565952
41FOXP3_21729870_ChIP-Seq_TREG_Human2.16898303
42ELK1_19687146_ChIP-ChIP_HELA_Human2.14782359
43RUNX_20019798_ChIP-Seq_JUKART_Human2.13107173
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.12489348
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05648985
46NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05389371
47KDM2B_26808549_Chip-Seq_SUP-B15_Human2.05256592
48BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03422393
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01475239
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.98353030
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.97980847
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.96517182
53KDM2B_26808549_Chip-Seq_DND41_Human1.93950359
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.89823539
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89043824
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88592227
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88491196
58TTF2_22483619_ChIP-Seq_HELA_Human1.87408645
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.86119332
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85969194
61DCP1A_22483619_ChIP-Seq_HELA_Human1.84601770
62LXR_22292898_ChIP-Seq_THP-1_Human1.84480950
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83941557
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81557625
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81390975
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.80940187
67* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79409934
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78267324
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76451297
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73978432
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73827030
72CIITA_25753668_ChIP-Seq_RAJI_Human1.72652335
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72633952
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71676032
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71196656
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70539288
77BP1_19119308_ChIP-ChIP_Hs578T_Human1.67942108
78GABP_19822575_ChIP-Seq_HepG2_Human1.67544452
79* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.66865583
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60560945
81* GATA1_19941827_ChIP-Seq_MEL_Mouse1.60009005
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59587371
83* GATA1_19941826_ChIP-Seq_K562_Human1.57399064
84IRF8_21731497_ChIP-ChIP_J774_Mouse1.56185240
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55911530
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53711939
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52137145
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51467896
89* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48097836
90SPI1_23547873_ChIP-Seq_NB4_Human1.47250989
91GATA1_22025678_ChIP-Seq_K562_Human1.47235319
92NCOR1_26117541_ChIP-Seq_K562_Human1.45934658
93* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45350366
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44179472
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43613928
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41634101
97* GATA3_27048872_Chip-Seq_THYMUS_Human1.40632222
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40547516
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35929492
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32862792
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32770669
102* BCL6_27268052_Chip-Seq_Bcells_Human1.32584768
103* BCOR_27268052_Chip-Seq_Bcells_Human1.32073585
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30792820
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29458884
106STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28763652
107PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26149987
108POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23117876
109E2F1_21310950_ChIP-Seq_MCF-7_Human1.22492199
110ELF1_20517297_ChIP-Seq_JURKAT_Human1.22433580
111* KDM2B_26808549_Chip-Seq_JURKAT_Human1.22081497
112ELK1_22589737_ChIP-Seq_MCF10A_Human1.21116848
113ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21113186
114* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20053301
115* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19580989
116RACK7_27058665_Chip-Seq_MCF-7_Human1.19324457
117* P68_20966046_ChIP-Seq_HELA_Human1.18744079
118PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16921021
119* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16611084
120TP63_19390658_ChIP-ChIP_HaCaT_Human1.15120835
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14021716
122GATA2_19941826_ChIP-Seq_K562_Human1.13187680
123CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13056174
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12713796
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11345741
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11058819
127VDR_24787735_ChIP-Seq_THP-1_Human1.10472913
128SA1_27219007_Chip-Seq_ERYTHROID_Human1.10435736
129STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10404822
130* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08870425
131MYC_18940864_ChIP-ChIP_HL60_Human1.08625132
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08493117
133RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06154141
134KDM5A_27292631_Chip-Seq_BREAST_Human1.04653690
135* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04067512
136HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03600787
137PU_27001747_Chip-Seq_BMDM_Mouse1.02996289
138CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02739314
139MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01687509
140* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99910591
141PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97422442
142IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96122267
143GATA3_26560356_Chip-Seq_TH2_Human0.95192422
144BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94753459
145SPI1_20517297_ChIP-Seq_HL60_Human0.94458134
146STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91789573
147CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91584220
148IRF8_22096565_ChIP-ChIP_GC-B_Human0.91319118
149ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90899927
150VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90419510
151IRF1_19129219_ChIP-ChIP_H3396_Human0.90370293
152ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89576945
153* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89524070
154VDR_21846776_ChIP-Seq_THP-1_Human0.88660108
155MYB_26560356_Chip-Seq_TH2_Human0.88506321
156KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87382868
157KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87382868
158KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87382868
159MYB_26560356_Chip-Seq_TH1_Human0.86294410
160CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85006573
161CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.83312649
162DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81833379
163SCL_19346495_ChIP-Seq_HPC-7_Human0.80860624
164E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80528996
165* MAF_26560356_Chip-Seq_TH2_Human0.79782203
166* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79174998
167LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78219474
168NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78060589
169HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77117790
170STAT3_1855785_ChIP-Seq_MESCs_Mouse0.76775984
171FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.75631773
172GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74312405

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.77201122
2MP0003693_abnormal_embryo_hatching3.73834353
3MP0003303_peritoneal_inflammation3.38724912
4MP0003111_abnormal_nucleus_morphology3.12877186
5MP0008058_abnormal_DNA_repair2.97255398
6MP0010094_abnormal_chromosome_stability2.92127364
7MP0006292_abnormal_olfactory_placode2.82309227
8MP0003763_abnormal_thymus_physiology2.74868356
9MP0003077_abnormal_cell_cycle2.72529280
10MP0004957_abnormal_blastocyst_morpholog2.57448201
11MP0005671_abnormal_response_to2.50029118
12MP0003300_gastrointestinal_ulcer2.41640328
13MP0001835_abnormal_antigen_presentation2.36148148
14MP0009278_abnormal_bone_marrow2.22003291
15MP0008877_abnormal_DNA_methylation2.20499097
16MP0008007_abnormal_cellular_replicative2.19836303
17MP0002396_abnormal_hematopoietic_system2.16852593
18MP0005075_abnormal_melanosome_morpholog2.13204646
19MP0001853_heart_inflammation2.10595252
20MP0003172_abnormal_lysosome_physiology2.04627044
21MP0003191_abnormal_cellular_cholesterol2.03522127
22MP0001800_abnormal_humoral_immune2.01862916
23MP0005174_abnormal_tail_pigmentation1.95539544
24* MP0002398_abnormal_bone_marrow1.94404161
25MP0003786_premature_aging1.93338530
26MP0005451_abnormal_body_composition1.93267578
27MP0001533_abnormal_skeleton_physiology1.90768717
28MP0004947_skin_inflammation1.90031988
29MP0005409_darkened_coat_color1.89013516
30MP0005000_abnormal_immune_tolerance1.88642097
31MP0001986_abnormal_taste_sensitivity1.87865670
32* MP0002723_abnormal_immune_serum1.87438670
33* MP0002420_abnormal_adaptive_immunity1.87171298
34MP0008932_abnormal_embryonic_tissue1.85176611
35* MP0001819_abnormal_immune_cell1.84694009
36MP0009333_abnormal_splenocyte_physiolog1.84265196
37MP0000703_abnormal_thymus_morphology1.83285796
38MP0002148_abnormal_hypersensitivity_rea1.82022681
39* MP0002452_abnormal_antigen_presenting1.80013218
40MP0004381_abnormal_hair_follicle1.76884399
41MP0009785_altered_susceptibility_to1.75216541
42* MP0000689_abnormal_spleen_morphology1.74927143
43* MP0002722_abnormal_immune_system1.71835165
44MP0002132_abnormal_respiratory_system1.69763735
45MP0002277_abnormal_respiratory_mucosa1.68918416
46MP0005058_abnormal_lysosome_morphology1.68048313
47MP0009379_abnormal_foot_pigmentation1.66705818
48* MP0000716_abnormal_immune_system1.65887599
49MP0000685_abnormal_immune_system1.64654332
50* MP0005025_abnormal_response_to1.63385112
51MP0003718_maternal_effect1.62059283
52MP0003436_decreased_susceptibility_to1.61953568
53MP0001790_abnormal_immune_system1.59951455
54MP0005387_immune_system_phenotype1.59951455
55MP0000015_abnormal_ear_pigmentation1.55881026
56* MP0002429_abnormal_blood_cell1.48556727
57MP0001188_hyperpigmentation1.44183133
58MP0003828_pulmonary_edema1.42728903
59* MP0002419_abnormal_innate_immunity1.41973461
60MP0001851_eye_inflammation1.37032083
61MP0000490_abnormal_crypts_of1.34669718
62MP0001529_abnormal_vocalization1.32014722
63MP0005464_abnormal_platelet_physiology1.31543737
64MP0004808_abnormal_hematopoietic_stem1.30910316
65MP0003136_yellow_coat_color1.30737207
66MP0003656_abnormal_erythrocyte_physiolo1.29800111
67MP0002405_respiratory_system_inflammati1.28958266
68MP0002160_abnormal_reproductive_system1.24312928
69MP0009764_decreased_sensitivity_to1.20040668
70MP0002095_abnormal_skin_pigmentation1.19622625
71MP0003183_abnormal_peptide_metabolism1.18319963
72MP0001873_stomach_inflammation1.16072297
73MP0002998_abnormal_bone_remodeling1.15101587
74MP0000858_altered_metastatic_potential1.14622042
75MP0005389_reproductive_system_phenotype1.13416470
76MP0000313_abnormal_cell_death1.13300298
77MP0002019_abnormal_tumor_incidence1.12304267
78MP0003806_abnormal_nucleotide_metabolis1.06056742
79MP0003075_altered_response_to1.03854669
80MP0003315_abnormal_perineum_morphology1.01839536
81MP0005083_abnormal_biliary_tract1.01367258
82MP0001545_abnormal_hematopoietic_system1.00642190
83MP0005397_hematopoietic_system_phenotyp1.00642190
84MP0001905_abnormal_dopamine_level0.99156414
85MP0003880_abnormal_central_pattern0.98280122
86MP0000350_abnormal_cell_proliferation0.97973468
87MP0010155_abnormal_intestine_physiology0.95332569
88MP0004883_abnormal_blood_vessel0.95311745
89MP0004133_heterotaxia0.94853295
90MP0003724_increased_susceptibility_to0.93047292
91MP0000465_gastrointestinal_hemorrhage0.92711029
92MP0008995_early_reproductive_senescence0.91762022
93MP0005076_abnormal_cell_differentiation0.91744827
94MP0002006_tumorigenesis0.91540371
95MP0001730_embryonic_growth_arrest0.90026072
96MP0005310_abnormal_salivary_gland0.89829221
97MP0004147_increased_porphyrin_level0.89613844
98MP0001919_abnormal_reproductive_system0.89232768
99MP0003866_abnormal_defecation0.88004212
100MP0000678_abnormal_parathyroid_gland0.87004251
101MP0009763_increased_sensitivity_to0.85903871
102MP0003186_abnormal_redox_activity0.85394778
103MP0006035_abnormal_mitochondrial_morpho0.85288152
104MP0002210_abnormal_sex_determination0.85014764
105MP0001845_abnormal_inflammatory_respons0.84545192
106MP0001663_abnormal_digestive_system0.84544008
107MP0006082_CNS_inflammation0.84327210
108MP0009840_abnormal_foam_cell0.83374517
109MP0003448_altered_tumor_morphology0.83080031
110MP0005166_decreased_susceptibility_to0.81705447
111MP0003941_abnormal_skin_development0.81199862
112MP0008004_abnormal_stomach_pH0.79394051
113MP0005164_abnormal_response_to0.78538531
114MP0000343_altered_response_to0.78145925
115MP0001145_abnormal_male_reproductive0.74105698
116MP0005390_skeleton_phenotype0.72268544
117MP0004510_myositis0.69333090
118MP0008469_abnormal_protein_level0.68856143
119MP0003123_paternal_imprinting0.66722496
120MP0000372_irregular_coat_pigmentation0.66044408
121MP0001929_abnormal_gametogenesis0.65959988
122MP0004185_abnormal_adipocyte_glucose0.65841498
123MP0003045_fibrosis0.65288207
124MP0000566_synostosis0.65259199
125MP0002009_preneoplasia0.64498587
126MP0004264_abnormal_extraembryonic_tissu0.64359750
127MP0000249_abnormal_blood_vessel0.64299088
128MP0003453_abnormal_keratinocyte_physiol0.64176980
129MP0002166_altered_tumor_susceptibility0.63734859
130MP0002933_joint_inflammation0.63420284
131MP0000609_abnormal_liver_physiology0.63085619
132MP0009765_abnormal_xenobiotic_induced0.62909114
133* MP0003795_abnormal_bone_structure0.62130179
134MP0008260_abnormal_autophagy0.60927778
135MP0008874_decreased_physiological_sensi0.60546877
136MP0000653_abnormal_sex_gland0.60505093
137MP0002163_abnormal_gland_morphology0.60181797
138MP0000604_amyloidosis0.59601641
139MP0009931_abnormal_skin_appearance0.56837856
140MP0002138_abnormal_hepatobiliary_system0.56162564
141MP0003690_abnormal_glial_cell0.54844277
142MP0003566_abnormal_cell_adhesion0.52569844
143MP0005319_abnormal_enzyme/_coenzyme0.51370919
144MP0003221_abnormal_cardiomyocyte_apopto0.50096077

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.27935159
2Recurrent bacterial skin infections (HP:0005406)5.10670220
3Myositis (HP:0100614)4.98030345
4* Abnormality of macrophages (HP:0004311)4.42615123
5Recurrent fungal infections (HP:0002841)4.33066069
6Orchitis (HP:0100796)4.32107022
7Stomatitis (HP:0010280)4.31670237
8Reticulocytopenia (HP:0001896)4.13473814
9Birth length less than 3rd percentile (HP:0003561)4.11872052
10Recurrent gram-negative bacterial infections (HP:0005420)4.02946562
11Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.00790900
12Abnormality of cells of the erythroid lineage (HP:0012130)4.00657179
13Optic neuritis (HP:0100653)3.99652271
14Retrobulbar optic neuritis (HP:0100654)3.99652271
15Meningitis (HP:0001287)3.85811889
16Increased IgE level (HP:0003212)3.79665834
17Abnormal number of erythroid precursors (HP:0012131)3.78431902
18Breast hypoplasia (HP:0003187)3.77370984
19Gastrointestinal infarctions (HP:0005244)3.62955523
20Progressive external ophthalmoplegia (HP:0000590)3.60308438
21Recurrent skin infections (HP:0001581)3.55359605
22Pustule (HP:0200039)3.49238891
23IgM deficiency (HP:0002850)3.48590385
24Chronic mucocutaneous candidiasis (HP:0002728)3.47966648
25Recurrent cutaneous fungal infections (HP:0011370)3.47966648
26Cellulitis (HP:0100658)3.46456507
27Epistaxis (HP:0000421)3.36483142
28Macrocytic anemia (HP:0001972)3.35244101
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.31493611
30Recurrent viral infections (HP:0004429)3.30976086
31Spontaneous hematomas (HP:0007420)3.28121273
32Chromosomal breakage induced by crosslinking agents (HP:0003221)3.18468993
33Vasculitis (HP:0002633)3.17571493
34Chromsome breakage (HP:0040012)3.09544473
35Gingivitis (HP:0000230)3.09355386
36Gastrointestinal inflammation (HP:0004386)3.07619260
37Duplicated collecting system (HP:0000081)3.06888540
38Urticaria (HP:0001025)3.06610609
39Inflammation of the large intestine (HP:0002037)3.00870537
40Keratoconjunctivitis sicca (HP:0001097)3.00042326
41Pallor (HP:0000980)2.94544809
42Chest pain (HP:0100749)2.93200013
43Abnormality of the renal collecting system (HP:0004742)2.86839506
44Hypochromic anemia (HP:0001931)2.82334433
45Colitis (HP:0002583)2.78526410
46Gingival bleeding (HP:0000225)2.78065040
47Keratoconjunctivitis (HP:0001096)2.77161233
48Hypochromic microcytic anemia (HP:0004840)2.76155918
49Petechiae (HP:0000967)2.75657134
50Episodic fever (HP:0001954)2.73260013
51Cerebral hypomyelination (HP:0006808)2.72461128
52Aplastic anemia (HP:0001915)2.70995591
53Purpura (HP:0000979)2.70317720
54Agammaglobulinemia (HP:0004432)2.67074092
55Osteomyelitis (HP:0002754)2.62749851
56Carpal bone hypoplasia (HP:0001498)2.61958585
573-Methylglutaconic aciduria (HP:0003535)2.61728685
58Increased serum ferritin (HP:0003281)2.61602118
59Abnormality of T cell physiology (HP:0011840)2.60345197
60Abnormal platelet volume (HP:0011876)2.59709248
61Pulmonary infiltrates (HP:0002113)2.59633851
62Hemoptysis (HP:0002105)2.57905188
63Exertional dyspnea (HP:0002875)2.54221499
64Arterial thrombosis (HP:0004420)2.52113996
65Increased IgM level (HP:0003496)2.50294557
66Acute necrotizing encephalopathy (HP:0006965)2.50025356
67Renal Fanconi syndrome (HP:0001994)2.49922864
68Mitochondrial inheritance (HP:0001427)2.49628927
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.49606927
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.49606927
71Increased hepatocellular lipid droplets (HP:0006565)2.47649328
72Type I transferrin isoform profile (HP:0003642)2.44265279
73Abnormality of the preputium (HP:0100587)2.44117264
74Type 2 muscle fiber atrophy (HP:0003554)2.43780382
75Chronic otitis media (HP:0000389)2.41146397
76IgG deficiency (HP:0004315)2.38720380
77Abnormality of iron homeostasis (HP:0011031)2.38679447
78Increased serum lactate (HP:0002151)2.38217385
79Anorexia (HP:0002039)2.37316994
80Panhypogammaglobulinemia (HP:0003139)2.33600214
81Meckel diverticulum (HP:0002245)2.32201498
82Rough bone trabeculation (HP:0100670)2.32010513
83Absent thumb (HP:0009777)2.31465428
84Bone marrow hypocellularity (HP:0005528)2.30788778
85Increased cerebral lipofuscin (HP:0011813)2.30405448
86Lymphoma (HP:0002665)2.29606884
87Eosinophilia (HP:0001880)2.28492411
88Aplasia/Hypoplasia of the earlobes (HP:0009906)2.27939647
89Hypertensive crisis (HP:0100735)2.27095470
90Hypergammaglobulinemia (HP:0010702)2.26547450
91Lymphopenia (HP:0001888)2.26483945
92Pulmonary embolism (HP:0002204)2.25405571
93Myelodysplasia (HP:0002863)2.25152630
94Absent radius (HP:0003974)2.25060556
95* Granulocytopenia (HP:0001913)2.24934681
96Premature graying of hair (HP:0002216)2.24374581
97Sepsis (HP:0100806)2.23717072
98Exercise intolerance (HP:0003546)2.22301192
99Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.22001529
100Polycythemia (HP:0001901)2.20779215
101Microvesicular hepatic steatosis (HP:0001414)2.19616924
102Abnormality of the ileum (HP:0001549)2.18933702
103Muscle fiber atrophy (HP:0100295)2.18554287
104T lymphocytopenia (HP:0005403)2.18513672
105Abnormal platelet function (HP:0011869)2.18478707
106Impaired platelet aggregation (HP:0003540)2.18478707
107Agnosia (HP:0010524)2.18287142
108Increased CSF lactate (HP:0002490)2.18073708
109Abnormality of eosinophils (HP:0001879)2.17475754
110Menorrhagia (HP:0000132)2.17193746
111Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.16806111
112Skin ulcer (HP:0200042)2.16594609
113Microcytic anemia (HP:0001935)2.16338981
114Cleft eyelid (HP:0000625)2.15736756
115Autoimmune hemolytic anemia (HP:0001890)2.15493498
116Asplenia (HP:0001746)2.14772545
117Abnormality of chromosome stability (HP:0003220)2.13912156
118Abnormality of cells of the lymphoid lineage (HP:0012140)2.13288549
119Cellular immunodeficiency (HP:0005374)2.12846979
120Patellar aplasia (HP:0006443)2.12289385
121Clubbing of toes (HP:0100760)2.11507911
122Oral leukoplakia (HP:0002745)2.11393575
123Verrucae (HP:0200043)2.11344246
124Papilloma (HP:0012740)2.11344246
125Aplasia/Hypoplasia of the sacrum (HP:0008517)2.10541158
126Testicular atrophy (HP:0000029)2.10336524
127Viral hepatitis (HP:0006562)2.09881722
128Pancytopenia (HP:0001876)2.09840737
129Aplasia involving forearm bones (HP:0009822)2.08681522
130Absent forearm bone (HP:0003953)2.08681522
131Hepatocellular necrosis (HP:0001404)2.08096495
132Abnormal delayed hypersensitivity skin test (HP:0002963)2.07801780
133Increased neuronal autofluorescent lipopigment (HP:0002074)2.07665201
134Abnormality of T cells (HP:0002843)2.07479474
135Abnormal mitochondria in muscle tissue (HP:0008316)2.07366389
136Acute lymphatic leukemia (HP:0006721)2.06582315
137Abnormality of T cell number (HP:0011839)2.05938214
138Prolonged bleeding time (HP:0003010)2.05536670
139Slow saccadic eye movements (HP:0000514)2.04175608
140Elevated erythrocyte sedimentation rate (HP:0003565)2.03519989
141Chronic obstructive pulmonary disease (HP:0006510)2.03115259
142Obstructive lung disease (HP:0006536)2.03115259
143Recurrent abscess formation (HP:0002722)2.02492308
144Amyloidosis (HP:0011034)2.02379444
145Abnormality of the pleura (HP:0002103)2.02344869
146Acute hepatic failure (HP:0006554)2.00935414
147Loss of speech (HP:0002371)2.00924222
148Interstitial pulmonary disease (HP:0006530)2.00854553
149Respiratory difficulties (HP:0002880)2.00639089
15011 pairs of ribs (HP:0000878)2.00516493
151Abnormality of the heme biosynthetic pathway (HP:0010472)2.00262635
152Gastrointestinal stroma tumor (HP:0100723)1.99850282
153Aplasia/Hypoplasia of the patella (HP:0006498)1.98433748
154Skin rash (HP:0000988)1.98038189
155Fatigue (HP:0012378)1.98019920
156Triphalangeal thumb (HP:0001199)1.95188283
157External ophthalmoplegia (HP:0000544)1.94138967
158Abnormality of transition element cation homeostasis (HP:0011030)1.93848121
159Horseshoe kidney (HP:0000085)1.93068033
160Glomerulopathy (HP:0100820)1.92878007
161B lymphocytopenia (HP:0010976)1.92386606
162Abnormality of B cell number (HP:0010975)1.92386606
163Dysostosis multiplex (HP:0000943)1.92158617
164* Hepatosplenomegaly (HP:0001433)1.91564177
165Aplasia/Hypoplasia of the spleen (HP:0010451)1.91427330
166Abnormality of the columella (HP:0009929)1.91147552
167Stomach cancer (HP:0012126)1.91053519
168Abnormality of secondary sexual hair (HP:0009888)1.90803543
169Abnormality of the axillary hair (HP:0100134)1.90803543
170Aplasia/Hypoplasia of the uvula (HP:0010293)1.90756645
171Abnormality of the fingertips (HP:0001211)1.90700727
172Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.90245366
173Autoimmune thrombocytopenia (HP:0001973)1.88544116
174Abnormality of glycosphingolipid metabolism (HP:0004343)1.88123695
175Lipid accumulation in hepatocytes (HP:0006561)1.84740250
176Leukocytosis (HP:0001974)1.83903671
177Severe combined immunodeficiency (HP:0004430)1.83209617
178Mediastinal lymphadenopathy (HP:0100721)1.82545027
179Abnormality of DNA repair (HP:0003254)1.82000298
180Encephalitis (HP:0002383)1.80670629
181Thrombocytosis (HP:0001894)1.79749794

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.89985251
2PLK44.21546146
3BUB14.17779410
4STK163.63874224
5IRAK43.46138323
6ERN13.07432371
7PRPF4B2.93010793
8MAP2K32.88835033
9ZAK2.75149088
10WEE12.52649646
11MAP4K12.39964462
12SRPK12.35250866
13TXK2.11975125
14CSK2.10327717
15EIF2AK12.05522298
16VRK11.88573809
17IRAK21.87471141
18EPHB11.82561022
19TRIB31.79853227
20TSSK61.76080816
21IRAK11.73195322
22NME21.69919865
23MAP3K131.67152937
24EIF2AK31.61914904
25TBK11.57494142
26MARK11.55330920
27CDC71.53711812
28NME11.52284306
29MAP3K31.48937504
30MST41.48550402
31TAOK31.46702696
32TAOK11.44872182
33SIK31.43445947
34TESK21.41717410
35SMG11.41244225
36TTK1.40421422
37BLK1.34260633
38CLK11.31342236
39PNCK1.27092970
40JAK11.26278235
41JAK21.25442672
42MAP3K11.25179812
43GRK61.23638151
44RIPK41.19206835
45TAOK21.16231154
46ATR1.15031860
47SIK21.13672147
48TEC1.13388419
49MATK1.12306979
50RPS6KB21.10013762
51BMPR21.09498224
52PTK61.06253875
53KDR1.03312971
54SIK11.02889565
55KSR21.01851711
56STK100.99346207
57PLK30.98939130
58MARK30.98084333
59TLK10.97169608
60PLK10.96482173
61MARK20.96146747
62SYK0.95869075
63IKBKB0.94064597
64BTK0.93424168
65CDK120.93369858
66MKNK10.93283532
67JAK30.92140263
68FGFR40.91834831
69ADRBK20.90511274
70LYN0.88670422
71GRK70.87944466
72KIT0.87643951
73ZAP700.85703300
74MAP3K60.85124506
75PDK10.84436298
76MAP3K70.83842564
77PIM20.83524919
78TYK20.82553897
79IKBKE0.82233985
80LCK0.80898597
81MAP3K120.80721292
82EPHA20.79917992
83HIPK20.79666625
84LRRK20.79425967
85ACVR1B0.78847057
86FES0.76621400
87STK40.76587060
88PDPK10.75967555
89ICK0.75963440
90CHEK20.75696889
91MAP3K140.75513633
92PRKD20.72214077
93RPS6KA50.71254637
94EIF2AK20.70952458
95MKNK20.69460510
96MAPK120.68524833
97PAK40.67923829
98CDK70.67609497
99AURKB0.67305479
100BMX0.66894989
101CDC42BPA0.65089793
102PKN20.64859367
103PASK0.64283917
104TNIK0.63694721
105DYRK30.63428375
106AURKA0.60687095
107PRKCI0.60187893
108PBK0.60091081
109RPS6KL10.59683172
110RPS6KC10.59683172
111PIM10.59448265
112CDK40.57942685
113BRD40.56757995
114MAPK110.56670334
115PRKCQ0.56245990
116MAP2K60.55846245
117FGFR30.53714704
118TGFBR10.53402118
119CDK190.52650311
120YES10.52502444
121RET0.52400165
122TNK20.51415052
123MAP2K20.51029018
124FYN0.49945854
125FGR0.49934712
126NLK0.49445247
127RPS6KA60.49239501
128MAP3K80.49046572
129ITK0.48930015
130CHEK10.48561152
131RAF10.48288226
132CSNK2A20.47720661
133NEK60.47560912
134CSNK2A10.45967754
135MAPKAPK20.44788491
136CAMK2B0.43844178
137PTK2B0.42794330
138BRSK20.42371714
139MAPKAPK30.41061949
140ABL20.40499859
141TGFBR20.40492839
142ATM0.40488946
143NEK20.40233369
144CAMKK10.40194900
145DYRK20.40167812
146RPS6KA40.39228052
147MAPK70.39165668
148CSF1R0.38783386
149PRKG20.38240060
150CDK80.37364788
151HCK0.36109857
152MAP3K20.35731069
153RPS6KA20.33832438
154EPHA30.32529389
155MAP3K110.31921625
156DAPK10.31506449
157TTN0.30698743
158MAP3K50.29099714
159CDK60.28889820
160STK240.27694946
161BRAF0.27534167
162PAK10.27253289
163MAPK30.26930562
164DYRK1B0.26162029

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.49613434
2DNA replication_Homo sapiens_hsa030303.98895330
3RNA polymerase_Homo sapiens_hsa030203.93623037
4Proteasome_Homo sapiens_hsa030503.81754905
5Mismatch repair_Homo sapiens_hsa034303.39959898
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.92702507
7Spliceosome_Homo sapiens_hsa030402.89496796
8Homologous recombination_Homo sapiens_hsa034402.61392520
9Pyrimidine metabolism_Homo sapiens_hsa002402.60090963
10Fanconi anemia pathway_Homo sapiens_hsa034602.43653882
11Nucleotide excision repair_Homo sapiens_hsa034202.34094035
12Staphylococcus aureus infection_Homo sapiens_hsa051502.31443027
13Base excision repair_Homo sapiens_hsa034102.26461462
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.19224254
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.02451480
16RNA transport_Homo sapiens_hsa030131.97210479
17Primary immunodeficiency_Homo sapiens_hsa053401.91483814
18Non-homologous end-joining_Homo sapiens_hsa034501.90500960
19RNA degradation_Homo sapiens_hsa030181.82435921
20Oxidative phosphorylation_Homo sapiens_hsa001901.81789307
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79709720
22Basal transcription factors_Homo sapiens_hsa030221.70152080
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69248997
24Toxoplasmosis_Homo sapiens_hsa051451.53034188
25Cell cycle_Homo sapiens_hsa041101.51812384
26Purine metabolism_Homo sapiens_hsa002301.51291955
27Viral myocarditis_Homo sapiens_hsa054161.48407948
28Parkinsons disease_Homo sapiens_hsa050121.46763537
29One carbon pool by folate_Homo sapiens_hsa006701.43597614
30Non-small cell lung cancer_Homo sapiens_hsa052231.41928109
31Platelet activation_Homo sapiens_hsa046111.41051650
32Huntingtons disease_Homo sapiens_hsa050161.39108724
33Epstein-Barr virus infection_Homo sapiens_hsa051691.37807391
34Chronic myeloid leukemia_Homo sapiens_hsa052201.34013311
35TNF signaling pathway_Homo sapiens_hsa046681.32241172
36Pancreatic cancer_Homo sapiens_hsa052121.27643184
37Protein export_Homo sapiens_hsa030601.25131898
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.23325619
39p53 signaling pathway_Homo sapiens_hsa041151.21052723
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.20997246
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20657697
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19103780
43VEGF signaling pathway_Homo sapiens_hsa043701.14955281
44Measles_Homo sapiens_hsa051621.13134762
45Phagosome_Homo sapiens_hsa041451.10231727
46Hepatitis C_Homo sapiens_hsa051601.09442663
47Graft-versus-host disease_Homo sapiens_hsa053321.08898009
48Alzheimers disease_Homo sapiens_hsa050101.06157597
49Hematopoietic cell lineage_Homo sapiens_hsa046401.01880017
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99500374
51Herpes simplex infection_Homo sapiens_hsa051680.97375015
52Allograft rejection_Homo sapiens_hsa053300.95871105
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.93772239
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.89583641
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88631168
56Antigen processing and presentation_Homo sapiens_hsa046120.88404497
57Salmonella infection_Homo sapiens_hsa051320.87551441
58Prolactin signaling pathway_Homo sapiens_hsa049170.87317604
59Lysosome_Homo sapiens_hsa041420.86379054
60mRNA surveillance pathway_Homo sapiens_hsa030150.83265216
61Renal cell carcinoma_Homo sapiens_hsa052110.80617241
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.79804708
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79276822
64Notch signaling pathway_Homo sapiens_hsa043300.78637914
65Endocytosis_Homo sapiens_hsa041440.78625897
66Autoimmune thyroid disease_Homo sapiens_hsa053200.77272536
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75709411
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72821194
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72070851
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71608787
71Leishmaniasis_Homo sapiens_hsa051400.71115440
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70633153
73T cell receptor signaling pathway_Homo sapiens_hsa046600.69313369
74Shigellosis_Homo sapiens_hsa051310.69092408
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.67393043
76Asthma_Homo sapiens_hsa053100.66941660
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65842965
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.65772808
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65597663
80mTOR signaling pathway_Homo sapiens_hsa041500.64455690
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63828292
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.63709871
83Endometrial cancer_Homo sapiens_hsa052130.63611117
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.62044169
85Choline metabolism in cancer_Homo sapiens_hsa052310.61225744
86Arachidonic acid metabolism_Homo sapiens_hsa005900.60667422
87Other glycan degradation_Homo sapiens_hsa005110.60467418
88Systemic lupus erythematosus_Homo sapiens_hsa053220.60395497
89Inositol phosphate metabolism_Homo sapiens_hsa005620.58511533
90HIF-1 signaling pathway_Homo sapiens_hsa040660.56812913
91Colorectal cancer_Homo sapiens_hsa052100.56400366
92Glutathione metabolism_Homo sapiens_hsa004800.54207280
93Insulin resistance_Homo sapiens_hsa049310.53525917
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52706364
95GnRH signaling pathway_Homo sapiens_hsa049120.52631371
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52467126
97Viral carcinogenesis_Homo sapiens_hsa052030.52392612
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51159222
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50468300
100FoxO signaling pathway_Homo sapiens_hsa040680.48531299
101Bladder cancer_Homo sapiens_hsa052190.45599212
102Rheumatoid arthritis_Homo sapiens_hsa053230.45409055
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45044238
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44782153
105HTLV-I infection_Homo sapiens_hsa051660.44488211
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43973588
107Amoebiasis_Homo sapiens_hsa051460.43780789
108ErbB signaling pathway_Homo sapiens_hsa040120.42657612
109Thyroid cancer_Homo sapiens_hsa052160.41833702
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.41056586
111B cell receptor signaling pathway_Homo sapiens_hsa046620.40643414
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40482355
113MAPK signaling pathway_Homo sapiens_hsa040100.39780147
114Pertussis_Homo sapiens_hsa051330.39008941
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38862116
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37920986
117Apoptosis_Homo sapiens_hsa042100.37635638
118Phototransduction_Homo sapiens_hsa047440.37552553
119Influenza A_Homo sapiens_hsa051640.36645051
120Sphingolipid metabolism_Homo sapiens_hsa006000.35668029
121Insulin signaling pathway_Homo sapiens_hsa049100.34879936
122Type II diabetes mellitus_Homo sapiens_hsa049300.34579016
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33968706
124Legionellosis_Homo sapiens_hsa051340.31250751
125Hepatitis B_Homo sapiens_hsa051610.31247292
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30365791
127Type I diabetes mellitus_Homo sapiens_hsa049400.30260614
128Metabolic pathways_Homo sapiens_hsa011000.30213930
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29951189
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29708833
131Pentose phosphate pathway_Homo sapiens_hsa000300.29278784
132Osteoclast differentiation_Homo sapiens_hsa043800.29136218
133Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28498422
134Oocyte meiosis_Homo sapiens_hsa041140.28279866
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27662868
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.27348957
137Collecting duct acid secretion_Homo sapiens_hsa049660.26626224
138Ether lipid metabolism_Homo sapiens_hsa005650.26027729
139Folate biosynthesis_Homo sapiens_hsa007900.25006403
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24740820
141Acute myeloid leukemia_Homo sapiens_hsa052210.22541931
142Linoleic acid metabolism_Homo sapiens_hsa005910.21954905
143African trypanosomiasis_Homo sapiens_hsa051430.21560684
144Tuberculosis_Homo sapiens_hsa051520.20013005
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19464297
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18981053
147Toll-like receptor signaling pathway_Homo sapiens_hsa046200.18506690
148Drug metabolism - other enzymes_Homo sapiens_hsa009830.17898051
149Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17582493
150Chemokine signaling pathway_Homo sapiens_hsa040620.16898592
151Malaria_Homo sapiens_hsa051440.16127557

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