UNC45A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002 [PubMed 12356907]; Chadli et al., 2006 [PubMed 16478993]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.02732549
2COPI coating of Golgi vesicle (GO:0048205)6.02732549
3protein retention in ER lumen (GO:0006621)4.71220004
4keratinocyte development (GO:0003334)4.65401270
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.48944421
6proline biosynthetic process (GO:0006561)4.39789226
7pentose-phosphate shunt (GO:0006098)4.32203743
8modulation by virus of host process (GO:0019054)4.27160079
9negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.23925843
10retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.16644535
11desmosome organization (GO:0002934)4.00387270
12protein localization to endosome (GO:0036010)3.92615712
13protein maturation by protein folding (GO:0022417)3.88827275
14regulation of mammary gland epithelial cell proliferation (GO:0033599)3.88361166
15NADPH regeneration (GO:0006740)3.81874170
16adherens junction assembly (GO:0034333)3.74973135
17glucose catabolic process (GO:0006007)3.74591467
18negative regulation of cell size (GO:0045792)3.74201362
19modulation by symbiont of host cellular process (GO:0044068)3.63011199
20planar cell polarity pathway involved in neural tube closure (GO:0090179)3.60958451
21regulation of translational fidelity (GO:0006450)3.59047790
22focal adhesion assembly (GO:0048041)3.58673310
23cell-substrate adherens junction assembly (GO:0007045)3.58673310
24cell-substrate junction assembly (GO:0007044)3.56354865
25regulation of early endosome to late endosome transport (GO:2000641)3.55512887
26basement membrane organization (GO:0071711)3.48807345
27apoptotic process involved in morphogenesis (GO:0060561)3.34957914
28negative regulation of execution phase of apoptosis (GO:1900118)3.30831158
29negative regulation of erythrocyte differentiation (GO:0045647)3.27229550
30peptidyl-arginine omega-N-methylation (GO:0035247)3.22091894
31sensory perception of smell (GO:0007608)3.20573883
32hair cycle (GO:0042633)3.19886954
33molting cycle (GO:0042303)3.19886954
34DNA unwinding involved in DNA replication (GO:0006268)3.17932735
35cranial nerve morphogenesis (GO:0021602)3.17779653
36limb bud formation (GO:0060174)3.17415686
37hemidesmosome assembly (GO:0031581)3.17035480
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.16472856
39spliceosomal tri-snRNP complex assembly (GO:0000244)3.14489499
40cornea development in camera-type eye (GO:0061303)3.12210156
41mesenchymal cell differentiation involved in renal system development (GO:2001012)3.07095725
42mesenchymal cell differentiation involved in kidney development (GO:0072161)3.07095725
43semaphorin-plexin signaling pathway (GO:0071526)3.06856669
44establishment of skin barrier (GO:0061436)3.06747125
45sympathetic nervous system development (GO:0048485)3.06489627
46activation of Rac GTPase activity (GO:0032863)3.04472794
47epithelial cell-cell adhesion (GO:0090136)3.01780990
48glucose 6-phosphate metabolic process (GO:0051156)3.00748943
49mannose metabolic process (GO:0006013)3.00738888
50epithelial cell differentiation involved in prostate gland development (GO:0060742)2.99069315
51phosphorelay signal transduction system (GO:0000160)2.96852169
52pinocytosis (GO:0006907)2.94973381
53barbed-end actin filament capping (GO:0051016)2.94001260
54pentose metabolic process (GO:0019321)2.92814577
55endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.89680754
56detection of calcium ion (GO:0005513)2.89448303
57positive regulation of Cdc42 GTPase activity (GO:0043089)2.88629368
58positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.87089292
59activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.85883260
60positive regulation of blood vessel endothelial cell migration (GO:0043536)2.84208627
61negative regulation of homotypic cell-cell adhesion (GO:0034111)2.84167512
62regulation of water loss via skin (GO:0033561)2.83519185
63cytoskeletal anchoring at plasma membrane (GO:0007016)2.82711870
64maternal placenta development (GO:0001893)2.79283167
65vascular endothelial growth factor signaling pathway (GO:0038084)2.78758458
66proline metabolic process (GO:0006560)2.77516790
67positive regulation of nuclease activity (GO:0032075)2.76353164
68GDP-mannose metabolic process (GO:0019673)2.74175253
69formation of translation preinitiation complex (GO:0001731)2.70762351
70eyelid development in camera-type eye (GO:0061029)2.69382485
71post-embryonic morphogenesis (GO:0009886)2.69297994
72UV protection (GO:0009650)2.68702200
73sensory perception of chemical stimulus (GO:0007606)2.68193314
74mitotic chromosome condensation (GO:0007076)2.67506539
75skin morphogenesis (GO:0043589)2.66377557
76negative regulation of viral release from host cell (GO:1902187)2.66284426
77negative regulation of adherens junction organization (GO:1903392)2.65473203
78negative regulation of focal adhesion assembly (GO:0051895)2.65473203
79negative regulation of cell junction assembly (GO:1901889)2.65473203
80positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.63686490
81peptidyl-proline hydroxylation (GO:0019511)2.61307506
82histone arginine methylation (GO:0034969)2.57763285
83endoplasmic reticulum unfolded protein response (GO:0030968)2.57720276
84nuclear envelope reassembly (GO:0031468)2.57343631
85mitotic nuclear envelope reassembly (GO:0007084)2.57343631
86vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.56926859
87regulation of integrin activation (GO:0033623)2.56780720
88regulation of platelet aggregation (GO:0090330)2.56381203
89keratinization (GO:0031424)2.56274421
90regulation of apoptotic process involved in morphogenesis (GO:1902337)2.56084951
913-UTR-mediated mRNA stabilization (GO:0070935)2.55956444
92establishment of apical/basal cell polarity (GO:0035089)2.55602424
93negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.52740738
94positive regulation of keratinocyte differentiation (GO:0045618)2.52179198
95positive regulation of CREB transcription factor activity (GO:0032793)2.51054461
96rRNA transcription (GO:0009303)2.50727058
97retina layer formation (GO:0010842)2.50500173
98ribosomal small subunit biogenesis (GO:0042274)2.50006468
99positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.49966989
100nucleobase-containing small molecule interconversion (GO:0015949)2.49067621
101stress fiber assembly (GO:0043149)2.48324375
102regulation of glucose import in response to insulin stimulus (GO:2001273)2.47505417
103hyaluronan catabolic process (GO:0030214)2.47503388
104calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.45832411
105regulation of nuclease activity (GO:0032069)2.44894046
106regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.44695363
107long-chain fatty acid biosynthetic process (GO:0042759)2.43192045
108amyloid precursor protein catabolic process (GO:0042987)2.43013831
109protein complex localization (GO:0031503)2.41979374
110negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.41657638
111ER-nucleus signaling pathway (GO:0006984)2.41231024
112branching involved in mammary gland duct morphogenesis (GO:0060444)2.40579082
113adenine nucleotide transport (GO:0051503)2.40555184
114embryonic camera-type eye development (GO:0031076)2.38137994
115regulation of timing of cell differentiation (GO:0048505)2.37660294
116neuronal action potential (GO:0019228)2.37313178
117cellular response to unfolded protein (GO:0034620)2.37132036
118intracellular estrogen receptor signaling pathway (GO:0030520)2.37068926
119vesicle coating (GO:0006901)2.36725250
120face development (GO:0060324)2.36529090
121convergent extension (GO:0060026)2.35819683
122positive T cell selection (GO:0043368)2.35477841
123negative regulation of catenin import into nucleus (GO:0035414)2.35039572
124peptidyl-arginine methylation (GO:0018216)2.33802910
125peptidyl-arginine N-methylation (GO:0035246)2.33802910
126retina vasculature morphogenesis in camera-type eye (GO:0061299)2.33588418
127head development (GO:0060322)2.33339824
128lateral sprouting from an epithelium (GO:0060601)2.33259178
129mesonephros development (GO:0001823)2.33016818
130protein-DNA complex disassembly (GO:0032986)2.31332835
131nucleosome disassembly (GO:0006337)2.31332835
132positive regulation of odontogenesis (GO:0042482)2.31188983
133positive regulation of receptor recycling (GO:0001921)2.30882330
134platelet aggregation (GO:0070527)2.28995181
135dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.28755432
136positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.28292405
137endodermal cell differentiation (GO:0035987)2.28023890
138modulation by virus of host morphology or physiology (GO:0019048)2.27253291
139cardiac right ventricle morphogenesis (GO:0003215)2.26691537
140regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.25991284
141ganglion development (GO:0061548)2.24994925
142cellular response to interleukin-15 (GO:0071350)2.24948052
143cranial nerve structural organization (GO:0021604)2.24652184
144atrioventricular valve morphogenesis (GO:0003181)2.20358719
145cranial nerve development (GO:0021545)2.19688092
146sensory perception of taste (GO:0050909)2.18006986
147interferon-gamma production (GO:0032609)2.16873772
148mesenchymal cell differentiation (GO:0048762)2.15657582
149leukocyte aggregation (GO:0070486)2.13847196
150positive regulation of protein kinase C signaling (GO:0090037)2.12313296
151multicellular organismal water homeostasis (GO:0050891)2.11892351
152regulation of interleukin-8 secretion (GO:2000482)2.07209237
153bundle of His cell to Purkinje myocyte communication (GO:0086069)2.07115074
154inner ear morphogenesis (GO:0042472)2.06371416
155wound healing, spreading of epidermal cells (GO:0035313)2.05709428
156forebrain neuron differentiation (GO:0021879)2.05382656
157olfactory bulb development (GO:0021772)2.05219637
158neuron remodeling (GO:0016322)2.02504969
159postsynaptic membrane organization (GO:0001941)2.02458954
160negative regulation of leukocyte chemotaxis (GO:0002689)2.02019676
161positive regulation of uterine smooth muscle contraction (GO:0070474)2.02011460
162regulation of rhodopsin mediated signaling pathway (GO:0022400)2.01206649
163positive regulation of interleukin-8 secretion (GO:2000484)2.00077931
164regulation of branching involved in salivary gland morphogenesis (GO:0060693)1.99805049
165facial nerve structural organization (GO:0021612)1.99449406
166cell proliferation in forebrain (GO:0021846)1.99427067
167neuron cell-cell adhesion (GO:0007158)1.98832638
168positive regulation of hair follicle development (GO:0051798)1.98041927
169positive regulation of hair cycle (GO:0042635)1.98041927
170keratinocyte proliferation (GO:0043616)1.97869859
171regulation of development, heterochronic (GO:0040034)1.97092052
172ear development (GO:0043583)1.96420602
173negative regulation of axon extension involved in axon guidance (GO:0048843)1.96144370
174regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.95973055
175positive regulation of astrocyte differentiation (GO:0048711)1.95514150
176photoreceptor cell maintenance (GO:0045494)1.95355842
177regulation of inositol phosphate biosynthetic process (GO:0010919)1.94388325
178photoreceptor cell differentiation (GO:0046530)1.93950291
179eye photoreceptor cell differentiation (GO:0001754)1.93950291
180positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)1.93231103
181anatomical structure arrangement (GO:0048532)1.93152267
182negative regulation of keratinocyte proliferation (GO:0010839)1.93143684
183positive thymic T cell selection (GO:0045059)1.92724342
184neuron recognition (GO:0008038)1.92569361
185smooth muscle cell differentiation (GO:0051145)1.92020043
186regulation of somitogenesis (GO:0014807)1.91601631
187response to interleukin-15 (GO:0070672)1.90599225
188glucosamine-containing compound catabolic process (GO:1901072)1.89767709
189positive regulation of bone mineralization (GO:0030501)1.89748412
190response to muramyl dipeptide (GO:0032495)1.89590666
191regulation of homotypic cell-cell adhesion (GO:0034110)1.89407160
192spinal cord motor neuron differentiation (GO:0021522)1.89268470
193bone trabecula formation (GO:0060346)1.88629760
194T cell selection (GO:0045058)1.88584690
195histone H3-K36 demethylation (GO:0070544)1.87983335
196rhodopsin mediated signaling pathway (GO:0016056)1.87934131

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.79019141
2EZH2_22144423_ChIP-Seq_EOC_Human3.53093161
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.76385097
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.72471537
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.69194744
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.62994223
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.60831886
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.48349541
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48248603
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.48224896
11E2F7_22180533_ChIP-Seq_HELA_Human2.46231888
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45049145
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45049145
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44353300
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42086744
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41346110
17GBX2_23144817_ChIP-Seq_PC3_Human2.40915451
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.39884124
19VDR_21846776_ChIP-Seq_THP-1_Human2.38331749
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37785378
21LXR_22292898_ChIP-Seq_THP-1_Human2.36551424
22MYC_22102868_ChIP-Seq_BL_Human2.33184185
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32722851
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29696405
25ZNF263_19887448_ChIP-Seq_K562_Human2.28842447
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.25839609
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.19189388
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15901610
29RACK7_27058665_Chip-Seq_MCF-7_Human2.11694735
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08086064
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03806228
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01954644
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.00698188
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99684735
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96958082
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89698692
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.88821142
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.87541152
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.83644584
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.83567272
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83450293
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.82668696
43DROSHA_22980978_ChIP-Seq_HELA_Human1.73473045
44* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.73255538
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70163736
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66381218
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.62549859
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58932484
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.56229059
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55174679
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55160921
52AHR_22903824_ChIP-Seq_MCF-7_Human1.54503155
53KDM2B_26808549_Chip-Seq_DND41_Human1.53936277
54TCF7_22412390_ChIP-Seq_EML_Mouse1.53401338
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52188825
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.51849713
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50672213
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49138160
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48697490
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46439821
61XRN2_22483619_ChIP-Seq_HELA_Human1.45555711
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.45544051
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44635535
64* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44049519
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43019634
66AR_21572438_ChIP-Seq_LNCaP_Human1.42873600
67P68_20966046_ChIP-Seq_HELA_Human1.41755082
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41251129
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41073094
70CLOCK_20551151_ChIP-Seq_293T_Human1.39549811
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38889158
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37535054
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36300183
74VDR_22108803_ChIP-Seq_LS180_Human1.36019987
75RNF2_27304074_Chip-Seq_NSC_Mouse1.34558693
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34106675
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33851220
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33480191
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33138779
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.32488370
81TP53_18474530_ChIP-ChIP_U2OS_Human1.31078023
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30921271
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.29895028
84ATF3_27146783_Chip-Seq_COLON_Human1.29379370
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28747697
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28662346
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28185632
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.28118132
89* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27800864
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27750066
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27725436
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27703228
93* TP53_22127205_ChIP-Seq_IMR90_Human1.27155893
94NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26468421
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.26459758
96MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25893545
97TP53_20018659_ChIP-ChIP_R1E_Mouse1.24305295
98HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22416089
99NCOR1_26117541_ChIP-Seq_K562_Human1.22020177
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.21814682
101THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21052540
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20385462
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.19276840
104STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.18324333
105TRIM28_21343339_ChIP-Seq_HEK293_Human1.17765822
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.15689675
107SMAD_19615063_ChIP-ChIP_OVARY_Human1.15662280
108FOXM1_23109430_ChIP-Seq_U2OS_Human1.15175369
109SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15146946
110TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14842673
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14427124
112* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14390943
113NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14056262
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13803365
115KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13546593
116TP63_19390658_ChIP-ChIP_HaCaT_Human1.13174848
117CREB1_26743006_Chip-Seq_LNCaP_Human1.12114084
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11025509
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10987496
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10735360
121SMC4_20622854_ChIP-Seq_HELA_Human1.10095287
122STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09815598
123GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09766025
124SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09591565
125TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09517563
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09513396
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09281535
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08925912
129SMAD3_21741376_ChIP-Seq_EPCs_Human1.08562244
130PIAS1_25552417_ChIP-Seq_VCAP_Human1.08358947
131KDM2B_26808549_Chip-Seq_JURKAT_Human1.07959318
132* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07561240
133CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07377463
134MAF_26560356_Chip-Seq_TH1_Human1.05684052
135POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05467667
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03253171
137VDR_24763502_ChIP-Seq_THP-1_Human1.03237479
138* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03132160
139PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02561464
140EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01919816
141E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01723951
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01655881
143ESR1_21235772_ChIP-Seq_MCF-7_Human1.00759643
144SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00320310
145TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00098653
146P300_19829295_ChIP-Seq_ESCs_Human0.99827482
147CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99748932
148TAF15_26573619_Chip-Seq_HEK293_Human0.99125532
149UBF1/2_26484160_Chip-Seq_HMECs_Human0.98978668
150ESR2_21235772_ChIP-Seq_MCF-7_Human0.98924735
151TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98809875
152* MAF_26560356_Chip-Seq_TH2_Human0.98194135
153BP1_19119308_ChIP-ChIP_Hs578T_Human0.98013082
154CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98010555
155UTX_26944678_Chip-Seq_JUKART_Human0.97568988
156PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97039293
157POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96437503
158GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95845492
159SMAD3_21741376_ChIP-Seq_HESCs_Human0.94766781
160REST_21632747_ChIP-Seq_MESCs_Mouse0.94492957
161KDM2B_26808549_Chip-Seq_K562_Human0.90556906
162SMAD4_21799915_ChIP-Seq_A2780_Human0.89434813
163NANOG_18555785_Chip-Seq_ESCs_Mouse0.88569523
164TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88498677
165CTCF_27219007_Chip-Seq_Bcells_Human0.88151434
166THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87837148
167P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86960119
168POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86543021
169TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86543021
170CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86043418
171TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85766711
172EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85383549
173SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85012099
174TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.84657472
175NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83341221
176CDX2_20551321_ChIP-Seq_CACO-2_Human0.82793706
177RUNX2_22187159_ChIP-Seq_PCA_Human0.81793213
178CMYC_18555785_Chip-Seq_ESCs_Mouse0.81659295
179SUZ12_18555785_Chip-Seq_ESCs_Mouse0.81536614
180CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81211438
181SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80125447
182NFE2_27457419_Chip-Seq_LIVER_Mouse0.79932898
183KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79530902
184SMAD4_21741376_ChIP-Seq_HESCs_Human0.79239323
185NMYC_18555785_Chip-Seq_ESCs_Mouse0.78157858
186TP53_16413492_ChIP-PET_HCT116_Human0.78121067
187KLF5_25053715_ChIP-Seq_YYC3_Human0.77948882
188E2F1_18555785_Chip-Seq_ESCs_Mouse0.77325149
189EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.76981376

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.59322338
2MP0008438_abnormal_cutaneous_collagen3.61344146
3MP0005058_abnormal_lysosome_morphology3.28840084
4MP0002877_abnormal_melanocyte_morpholog3.13056625
5MP0004381_abnormal_hair_follicle3.02712509
6MP0005377_hearing/vestibular/ear_phenot2.88729434
7MP0003878_abnormal_ear_physiology2.88729434
8MP0002102_abnormal_ear_morphology2.86440678
9MP0001849_ear_inflammation2.84692395
10MP0010234_abnormal_vibrissa_follicle2.77927675
11MP0004272_abnormal_basement_membrane2.67981051
12MP0000383_abnormal_hair_follicle2.66018350
13MP0000537_abnormal_urethra_morphology2.38036977
14MP0008789_abnormal_olfactory_epithelium2.36231532
15MP0002098_abnormal_vibrissa_morphology2.32857080
16MP0004742_abnormal_vestibular_system2.29160101
17MP0005645_abnormal_hypothalamus_physiol2.27014792
18MP0002277_abnormal_respiratory_mucosa2.12494644
19MP0001984_abnormal_olfaction2.08953202
20MP0000579_abnormal_nail_morphology2.06058543
21MP0001188_hyperpigmentation1.99055316
22MP0005394_taste/olfaction_phenotype1.94848534
23MP0005499_abnormal_olfactory_system1.94848534
24MP0002796_impaired_skin_barrier1.93949780
25MP0009840_abnormal_foam_cell1.91158984
26MP0010030_abnormal_orbit_morphology1.90499473
27MP0010678_abnormal_skin_adnexa1.87934940
28MP0003941_abnormal_skin_development1.78734488
29MP0005076_abnormal_cell_differentiation1.76103371
30MP0000467_abnormal_esophagus_morphology1.76038789
31MP0002249_abnormal_larynx_morphology1.69051453
32MP0000762_abnormal_tongue_morphology1.64846033
33MP0000566_synostosis1.64312590
34MP0000678_abnormal_parathyroid_gland1.63234782
35MP0001346_abnormal_lacrimal_gland1.61072297
36MP0003938_abnormal_ear_development1.60295388
37MP0006292_abnormal_olfactory_placode1.59721318
38MP0003136_yellow_coat_color1.59086202
39MP0004233_abnormal_muscle_weight1.58076452
40MP0003045_fibrosis1.56522433
41MP0003191_abnormal_cellular_cholesterol1.51267606
42MP0001485_abnormal_pinna_reflex1.48646179
43MP0009278_abnormal_bone_marrow1.47506692
44MP0000026_abnormal_inner_ear1.47019586
45MP0002089_abnormal_postnatal_growth/wei1.45639835
46MP0000858_altered_metastatic_potential1.45617633
47MP0005464_abnormal_platelet_physiology1.43878832
48MP0004185_abnormal_adipocyte_glucose1.40124193
49MP0003279_aneurysm1.38797309
50MP0003091_abnormal_cell_migration1.38663852
51MP0003172_abnormal_lysosome_physiology1.38400905
52MP0000647_abnormal_sebaceous_gland1.38258867
53MP0001730_embryonic_growth_arrest1.38066289
54MP0005423_abnormal_somatic_nervous1.36945452
55MP0001348_abnormal_lacrimal_gland1.35566652
56MP0010352_gastrointestinal_tract_polyps1.33439081
57MP0000003_abnormal_adipose_tissue1.32248249
58MP0005275_abnormal_skin_tensile1.31726756
59MP0000049_abnormal_middle_ear1.31588612
60MP0003111_abnormal_nucleus_morphology1.30950717
61MP0004782_abnormal_surfactant_physiolog1.30425606
62MP0002060_abnormal_skin_morphology1.30379498
63MP0009053_abnormal_anal_canal1.29185501
64MP0002184_abnormal_innervation1.29044579
65MP0001486_abnormal_startle_reflex1.28619731
66MP0005501_abnormal_skin_physiology1.27907346
67MP0003693_abnormal_embryo_hatching1.26645942
68MP0002254_reproductive_system_inflammat1.24868673
69MP0002735_abnormal_chemical_nociception1.22008192
70MP0005387_immune_system_phenotype1.21499221
71MP0001790_abnormal_immune_system1.21499221
72MP0002233_abnormal_nose_morphology1.20488881
73MP0006072_abnormal_retinal_apoptosis1.20099902
74MP0005409_darkened_coat_color1.19799873
75MP0010368_abnormal_lymphatic_system1.19599568
76MP0004264_abnormal_extraembryonic_tissu1.19266776
77MP0005623_abnormal_meninges_morphology1.18765090
78MP0005023_abnormal_wound_healing1.17898730
79MP0001986_abnormal_taste_sensitivity1.17521831
80MP0010386_abnormal_urinary_bladder1.17348879
81MP0001216_abnormal_epidermal_layer1.16650100
82MP0010771_integument_phenotype1.16434212
83MP0008932_abnormal_embryonic_tissue1.15531433
84MP0002234_abnormal_pharynx_morphology1.15330169
85MP0005083_abnormal_biliary_tract1.13004674
86MP0004957_abnormal_blastocyst_morpholog1.12472985
87MP0003763_abnormal_thymus_physiology1.12346236
88MP0002751_abnormal_autonomic_nervous1.11759079
89MP0001661_extended_life_span1.10528672
90MP0001501_abnormal_sleep_pattern1.09515720
91MP0005621_abnormal_cell_physiology1.08931185
92MP0003453_abnormal_keratinocyte_physiol1.08605656
93MP0003787_abnormal_imprinting1.08571010
94MP0002177_abnormal_outer_ear1.07840854
95MP0002132_abnormal_respiratory_system1.07599618
96MP0004858_abnormal_nervous_system1.06345672
97MP0000681_abnormal_thyroid_gland1.05239884
98MP0002080_prenatal_lethality1.04165281
99MP0004808_abnormal_hematopoietic_stem1.04162987
100MP0005375_adipose_tissue_phenotype1.03544411
101MP0005171_absent_coat_pigmentation1.02272404
102MP0000613_abnormal_salivary_gland1.01540373
103MP0005551_abnormal_eye_electrophysiolog1.01179354
104MP0004510_myositis1.00331694
105MP0009931_abnormal_skin_appearance1.00328608
106MP0000427_abnormal_hair_cycle0.99919011
107MP0005310_abnormal_salivary_gland0.99135205
108MP0001963_abnormal_hearing_physiology0.98838533
109MP0000350_abnormal_cell_proliferation0.97656061
110MP0002752_abnormal_somatic_nervous0.97130798
111MP0000767_abnormal_smooth_muscle0.96994708
112MP0003300_gastrointestinal_ulcer0.96919923
113MP0000490_abnormal_crypts_of0.96890954
114MP0001958_emphysema0.96862161
115MP0000015_abnormal_ear_pigmentation0.96124805
116MP0003879_abnormal_hair_cell0.95991583
117MP0001915_intracranial_hemorrhage0.95696658
118MP0009250_abnormal_appendicular_skeleto0.95637722
119MP0000358_abnormal_cell_content/0.95030533
120MP0005666_abnormal_adipose_tissue0.94862325
121MP0005257_abnormal_intraocular_pressure0.94520060
122MP0000377_abnormal_hair_follicle0.94515876
123MP0003123_paternal_imprinting0.94038003
124MP0009384_cardiac_valve_regurgitation0.93854390
125MP0002086_abnormal_extraembryonic_tissu0.93463945
126MP0003984_embryonic_growth_retardation0.93407834
127MP0009672_abnormal_birth_weight0.92371497
128MP0005380_embryogenesis_phenotype0.91839483
129MP0001672_abnormal_embryogenesis/_devel0.91839483
130MP0008260_abnormal_autophagy0.91744507
131MP0003385_abnormal_body_wall0.91154226
132MP0005384_cellular_phenotype0.90574179
133MP0003724_increased_susceptibility_to0.88335426
134MP0001243_abnormal_dermal_layer0.87304353
135MP0000470_abnormal_stomach_morphology0.86412402
136MP0002998_abnormal_bone_remodeling0.86358856
137MP0002088_abnormal_embryonic_growth/wei0.86349297
138MP0002557_abnormal_social/conspecific_i0.85863777
139MP0003942_abnormal_urinary_system0.83873289
140MP0000778_abnormal_nervous_system0.83557889
141MP0008004_abnormal_stomach_pH0.83400342
142MP0000733_abnormal_muscle_development0.83001784
143MP0003755_abnormal_palate_morphology0.82779287
144MP0001502_abnormal_circadian_rhythm0.82486523
145MP0003329_amyloid_beta_deposits0.82134434
146MP0004134_abnormal_chest_morphology0.81739855
147MP0000631_abnormal_neuroendocrine_gland0.79599852
148MP0000462_abnormal_digestive_system0.78856379
149MP0005000_abnormal_immune_tolerance0.77493710
150MP0002933_joint_inflammation0.77304852
151MP0002085_abnormal_embryonic_tissue0.77260147
152MP0003077_abnormal_cell_cycle0.76944728
153MP0000313_abnormal_cell_death0.75038227
154MP0003315_abnormal_perineum_morphology0.74889782
155MP0001542_abnormal_bone_strength0.74691699
156MP0003566_abnormal_cell_adhesion0.74456903
157MP0009379_abnormal_foot_pigmentation0.74096306
158MP0006276_abnormal_autonomic_nervous0.73665955
159MP0001664_abnormal_digestion0.73107761
160MP0001340_abnormal_eyelid_morphology0.72726471
161MP0005671_abnormal_response_to0.72553392
162MP0005451_abnormal_body_composition0.72527200
163MP0003880_abnormal_central_pattern0.72385614
164MP0005508_abnormal_skeleton_morphology0.70502453
165MP0002116_abnormal_craniofacial_bone0.70395566
166MP0004947_skin_inflammation0.70376891
167MP0002697_abnormal_eye_size0.68427815
168MP0002084_abnormal_developmental_patter0.67792344
169MP0000534_abnormal_ureter_morphology0.67652078
170MP0000477_abnormal_intestine_morphology0.67090288
171MP0005253_abnormal_eye_physiology0.66657423

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.46858930
2Aplasia cutis congenita (HP:0001057)4.14950228
3Protrusio acetabuli (HP:0003179)4.08717924
4Hyperacusis (HP:0010780)3.92051305
5Parakeratosis (HP:0001036)3.66162664
6Upper limb muscle weakness (HP:0003484)3.55305536
7Lip pit (HP:0100267)3.25566330
8Vertebral compression fractures (HP:0002953)3.22612544
9Congenital stationary night blindness (HP:0007642)3.16382632
10Cervical subluxation (HP:0003308)3.10170373
11Onycholysis (HP:0001806)3.03067405
12Morphological abnormality of the middle ear (HP:0008609)2.89062431
13Atrophic scars (HP:0001075)2.85453183
14Septo-optic dysplasia (HP:0100842)2.83375611
15Thick nail (HP:0001805)2.82999634
16Milia (HP:0001056)2.80130645
17Ulnar bowing (HP:0003031)2.79082985
18Xerostomia (HP:0000217)2.74927669
19Unilateral renal agenesis (HP:0000122)2.71597964
20Absent rod-and cone-mediated responses on ERG (HP:0007688)2.69584243
21White forelock (HP:0002211)2.69095076
22Abnormality of the distal phalanges of the toes (HP:0010182)2.67072673
23Hypotrichosis (HP:0001006)2.65696726
24Insomnia (HP:0100785)2.65571077
25Chronic sinusitis (HP:0011109)2.65038837
26J-shaped sella turcica (HP:0002680)2.64319407
27Cerebral aneurysm (HP:0004944)2.62724541
28Achilles tendon contracture (HP:0001771)2.59222797
29Distal upper limb amyotrophy (HP:0007149)2.58446604
30Upper limb amyotrophy (HP:0009129)2.58446604
31Increased IgE level (HP:0003212)2.58369105
32Abnormal ciliary motility (HP:0012262)2.49611581
33Short nail (HP:0001799)2.46724413
34Plantar hyperkeratosis (HP:0007556)2.44776802
35Hypoplasia of the iris (HP:0007676)2.44483019
36Increased connective tissue (HP:0009025)2.44429936
37Congenital sensorineural hearing impairment (HP:0008527)2.44166963
38Long palpebral fissure (HP:0000637)2.43332626
39Shallow orbits (HP:0000586)2.42829418
40Disproportionate tall stature (HP:0001519)2.40246944
41Dynein arm defect of respiratory motile cilia (HP:0012255)2.40107170
42Absent/shortened dynein arms (HP:0200106)2.40107170
43Spinal rigidity (HP:0003306)2.39996836
44Natal tooth (HP:0000695)2.39720640
45Back pain (HP:0003418)2.39290191
46Fragile nails (HP:0001808)2.36607336
47Blue sclerae (HP:0000592)2.36068842
48Abnormality of the Achilles tendon (HP:0005109)2.35388266
49Broad face (HP:0000283)2.34542194
50Cholecystitis (HP:0001082)2.33973369
51Abnormal gallbladder physiology (HP:0012438)2.33973369
52Trismus (HP:0000211)2.32682260
53Bony spicule pigmentary retinopathy (HP:0007737)2.31606934
54Conical tooth (HP:0000698)2.31296303
55Patchy hypopigmentation of hair (HP:0011365)2.30034141
56Ankle contracture (HP:0006466)2.29838387
57Amelogenesis imperfecta (HP:0000705)2.28961588
58Bladder diverticulum (HP:0000015)2.28613895
59Abnormal rod and cone electroretinograms (HP:0008323)2.24313189
60Nasolacrimal duct obstruction (HP:0000579)2.24232889
61Popliteal pterygium (HP:0009756)2.23987295
62Decreased central vision (HP:0007663)2.23013933
63Broad distal phalanx of finger (HP:0009836)2.21420307
64Premature skin wrinkling (HP:0100678)2.21355834
65Biconcave vertebral bodies (HP:0004586)2.20709115
66Duplicated collecting system (HP:0000081)2.18267749
67Genu recurvatum (HP:0002816)2.17957613
68Aplasia involving bones of the upper limbs (HP:0009823)2.15937751
69Aplasia of the phalanges of the hand (HP:0009802)2.15937751
70Aplasia involving bones of the extremities (HP:0009825)2.15937751
71Nonimmune hydrops fetalis (HP:0001790)2.15332214
72Renal agenesis (HP:0000104)2.14880142
73Mixed hearing impairment (HP:0000410)2.14614872
74Thin bony cortex (HP:0002753)2.14130902
75Abnormality of the thoracic spine (HP:0100711)2.13354932
76Advanced eruption of teeth (HP:0006288)2.13066819
77Flat acetabular roof (HP:0003180)2.10812261
78Exotropia (HP:0000577)2.10661666
79Abnormality of the renal collecting system (HP:0004742)2.08788500
80Overfolded helix (HP:0000396)2.08016495
81Selective tooth agenesis (HP:0001592)2.07793538
82Dysostosis multiplex (HP:0000943)2.06361823
83Reticulocytosis (HP:0001923)2.05385578
84Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05057730
85Abnormality of the nasal septum (HP:0000419)2.04727569
86Abnormality of oral frenula (HP:0000190)2.04577963
87Increased mean platelet volume (HP:0011877)2.04175753
88Pili torti (HP:0003777)2.01189625
89Chin dimple (HP:0010751)2.00642463
90Ankyloglossia (HP:0010296)2.00464972
91Chronic otitis media (HP:0000389)2.00340629
92Alopecia of scalp (HP:0002293)2.00148621
93Hand muscle atrophy (HP:0009130)1.99692856
94Atelectasis (HP:0100750)1.99184760
95Distal lower limb amyotrophy (HP:0008944)1.98445475
96Distal lower limb muscle weakness (HP:0009053)1.97414847
97Submucous cleft hard palate (HP:0000176)1.97412476
98Congenital glaucoma (HP:0001087)1.96795974
99Elbow flexion contracture (HP:0002987)1.96597560
100Stridor (HP:0010307)1.95772682
101Follicular hyperkeratosis (HP:0007502)1.95075245
102Abnormality of the lacrimal duct (HP:0011481)1.95061021
103Cheilitis (HP:0100825)1.95011148
104Thoracic kyphosis (HP:0002942)1.94429288
105Wormian bones (HP:0002645)1.94372033
106Recurrent corneal erosions (HP:0000495)1.93702881
107Abnormally folded helix (HP:0008544)1.93339758
108Febrile seizures (HP:0002373)1.92961631
109Abnormality of the dental pulp (HP:0006479)1.91263104
110Abnormal platelet volume (HP:0011876)1.90721689
111Fragile skin (HP:0001030)1.90567021
112Abnormal respiratory motile cilium morphology (HP:0005938)1.88293838
113Abnormal respiratory epithelium morphology (HP:0012253)1.88293838
114Increased variability in muscle fiber diameter (HP:0003557)1.87779983
115Elfin facies (HP:0004428)1.87515144
116Mitral regurgitation (HP:0001653)1.86413792
117Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86275582
118Absent eyebrow (HP:0002223)1.86200432
119Generalized amyotrophy (HP:0003700)1.85539657
120Persistence of primary teeth (HP:0006335)1.85409434
121Pointed chin (HP:0000307)1.85186902
122Abnormality of calcium-phosphate metabolism (HP:0100530)1.85116897
123Asymmetry of the thorax (HP:0001555)1.85016019
124Duplication of thumb phalanx (HP:0009942)1.84931213
125Renal duplication (HP:0000075)1.84337139
126Patellar dislocation (HP:0002999)1.84252810
127Abnormality of dentin (HP:0010299)1.82711733
128Centrally nucleated skeletal muscle fibers (HP:0003687)1.80780657
129Corneal erosion (HP:0200020)1.80184780
130Alacrima (HP:0000522)1.78581389
131Difficulty climbing stairs (HP:0003551)1.77712524
132Joint stiffness (HP:0001387)1.77436937
133Truncus arteriosus (HP:0001660)1.76806543
134Woolly hair (HP:0002224)1.76041783
135Overriding aorta (HP:0002623)1.75382071
136Dilatation of the ascending aorta (HP:0005111)1.74991664
137Ulnar claw (HP:0001178)1.74629275
138Bowed forearm bones (HP:0003956)1.74606817
139Bowing of the arm (HP:0006488)1.74606817
140Entropion (HP:0000621)1.74129617
141Nail dystrophy (HP:0008404)1.73788177
142Short clavicles (HP:0000894)1.73609734
143Abnormality of molar (HP:0011077)1.73519138
144Abnormality of molar morphology (HP:0011070)1.73519138
145Abnormality of primary teeth (HP:0006481)1.73402397
146Turricephaly (HP:0000262)1.73295739
147Hypoplasia of dental enamel (HP:0006297)1.72995468
148Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.72066563
149Bilateral sensorineural hearing impairment (HP:0008619)1.71508865
150Abnormality of the umbilical cord (HP:0010881)1.71460055
151Mildly elevated creatine phosphokinase (HP:0008180)1.71414344
152Concave nail (HP:0001598)1.71229237
153Abnormality of the acetabulum (HP:0003170)1.70817944
154Abnormal hair laboratory examination (HP:0003328)1.70338183
155Recurrent sinusitis (HP:0011108)1.70031079
156Abnormal respiratory motile cilium physiology (HP:0012261)1.69836730
157Eczematoid dermatitis (HP:0000976)1.69199898
158Abnormality of the nasolacrimal system (HP:0000614)1.67040819
159Right ventricular cardiomyopathy (HP:0011663)1.66363713
160Progressive muscle weakness (HP:0003323)1.66235699
161Retrobulbar optic neuritis (HP:0100654)1.66042766
162Optic neuritis (HP:0100653)1.66042766
163Long toe (HP:0010511)1.65980754
164Abnormality of skeletal muscle fiber size (HP:0012084)1.64674055
165Ragged-red muscle fibers (HP:0003200)1.64492169
166Hemorrhage of the eye (HP:0011885)1.63889470
167Palmoplantar hyperkeratosis (HP:0000972)1.63888286
168Joint laxity (HP:0001388)1.63802162
169Urinary glycosaminoglycan excretion (HP:0003541)1.63773427
170Mucopolysacchariduria (HP:0008155)1.63773427
171Hypohidrosis (HP:0000966)1.63744101
172Attenuation of retinal blood vessels (HP:0007843)1.62956209
173Hyperphosphatemia (HP:0002905)1.62684044
174Mitral valve prolapse (HP:0001634)1.62561407
175Hyperparathyroidism (HP:0000843)1.62164221
176Broad metatarsal (HP:0001783)1.62074830
177Deviation of the thumb (HP:0009603)1.61914863
178Spinal cord compression (HP:0002176)1.61729950
179Lower limb amyotrophy (HP:0007210)1.61631709
180Abnormality of the dental root (HP:0006486)1.61452356
181Taurodontia (HP:0000679)1.61452356
182Abnormality of permanent molar morphology (HP:0011071)1.61452356
183Abnormality of reticulocytes (HP:0004312)1.60879253
184Osteolytic defects of the hand bones (HP:0009699)1.60313432
185Osteolytic defects of the phalanges of the hand (HP:0009771)1.60313432
186Hyperkalemia (HP:0002153)1.58777465
187Menorrhagia (HP:0000132)1.58772752
188Increased IgM level (HP:0003496)1.58435163
189Abnormality of dental color (HP:0011073)1.58426103
190Abnormality of the distal phalanx of the thumb (HP:0009617)1.57330292
191Abnormality of the parietal bone (HP:0002696)1.56952694
192Interstitial pulmonary disease (HP:0006530)1.56924063
193Abnormality of the tricuspid valve (HP:0001702)1.56414019
194Neonatal death (HP:0003811)1.56308438
195Increased corneal curvature (HP:0100692)1.56148732

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.99833125
2TRIB34.93081702
3SMG14.08012499
4NME23.35181694
5EEF2K3.19080229
6ICK2.79833269
7RIPK12.65790282
8SIK22.60626102
9PRPF4B2.39048374
10SIK32.36085871
11EPHB12.25068856
12MAPK152.17796461
13MAP3K142.08177573
14CASK2.05921906
15GRK12.05392560
16TESK21.98878895
17TXK1.93324143
18EPHA31.91180859
19EPHA21.89066955
20PKN21.85893863
21TNIK1.78834561
22SCYL21.78480734
23CDK121.76751836
24INSRR1.76344929
25KDR1.75685482
26PAK41.67242921
27TTN1.63267122
28EPHB21.61214557
29TESK11.61212103
30PDGFRA1.59349261
31BMPR1B1.54518341
32IRAK11.45398694
33MST41.39383541
34PKN11.37443317
35FGR1.37281452
36FER1.33611263
37DMPK1.32354882
38MAP3K131.32222745
39MAP3K111.31388993
40PIM21.26717944
41PRKD21.26675411
42MAP2K31.25122653
43NLK1.24504141
44PRKD31.24156043
45RPS6KB21.20044519
46NEK61.18503488
47MTOR1.16181195
48MARK21.16039586
49NTRK31.14076556
50HIPK21.13454631
51MAP4K11.09788325
52NTRK11.09718402
53LMTK21.09291919
54MKNK21.06963702
55TAOK21.06488159
56RPS6KA21.05433767
57NUAK11.03914687
58PTK61.03658233
59BMX1.03147415
60ARAF1.03053910
61SIK11.00495133
62MAP3K61.00050951
63ERN10.97503695
64CLK10.95570350
65MAPK70.94302294
66CDC42BPA0.92930531
67CDK70.89117565
68MAP3K100.88886676
69CAMK1D0.85968799
70LRRK20.85515043
71MAPK130.84539605
72CSK0.84534839
73LATS20.83491821
74TBK10.83038523
75MAP3K80.82372548
76MAPKAPK30.81481161
77VRK20.80242451
78DAPK30.79834061
79ILK0.78159253
80PRKCE0.78050932
81HCK0.77291214
82MET0.77009643
83IRAK20.76883586
84IKBKB0.75111623
85RIPK40.73905148
86TAOK10.73722083
87ITK0.72220488
88BRAF0.70823965
89AURKA0.70148134
90ADRBK20.69561533
91IKBKE0.69472672
92MAP2K20.69238898
93PAK20.68271460
94BMPR20.66684688
95MAP3K30.66625048
96CSNK1A1L0.66334998
97JAK10.66067725
98DDR20.64647396
99STK390.64351630
100PRKCQ0.64162067
101STK160.63961277
102KSR20.63954934
103PRKCI0.63141058
104AKT20.62594177
105IRAK30.62376758
106IRAK40.61894036
107CDK30.61451162
108PTK20.61274477
109MST1R0.60574201
110MAP3K10.60570483
111JAK30.60322832
112FGFR40.59939442
113CAMK2B0.58893500
114PDPK10.57367357
115CDK40.57156004
116MAPK110.56609450
117MAP3K20.56140894
118DAPK20.54668609
119PRKG20.54604970
120RPS6KC10.54234506
121RPS6KL10.54234506
122FYN0.53540738
123GRK50.53479794
124MAPKAPK20.52082568
125LIMK10.51790387
126INSR0.51710050
127RPS6KA60.51235937
128CHUK0.51121879
129DYRK1A0.49683459
130GRK60.49003448
131PAK10.48783183
132CDK90.46856797
133BCR0.46420099
134RET0.46165410
135EIF2AK20.45768687
136TGFBR20.45630518
137NTRK20.45626574
138LCK0.45592558
139GSK3A0.45547086
140CDK80.45223185
141PBK0.44970859
142RPS6KA40.44577352
143MAP3K90.44360287
144TNK20.44258395
145RPS6KA50.43330895
146AKT30.43304176
147CAMK1G0.42092547
148TIE10.42088134
149EIF2AK10.41656441
150FES0.41437364
151PDGFRB0.41288995
152ROCK20.40536408
153MARK10.40248125
154ABL20.40008127
155DYRK20.39592387
156WNK40.38509939
157CAMK2G0.38237792
158CHEK20.38222420
159TYK20.37927319
160TEC0.37775289
161ZAP700.37302236
162DAPK10.37086877
163BUB10.34834548
164MYLK0.33443011
165FLT30.32876126
166MOS0.31613410
167CDK11A0.31247799
168NEK20.30981330

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.11232240
2Phototransduction_Homo sapiens_hsa047442.86492723
3Pentose phosphate pathway_Homo sapiens_hsa000302.76124764
4Bladder cancer_Homo sapiens_hsa052192.28978986
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.23839955
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.22617954
7Central carbon metabolism in cancer_Homo sapiens_hsa052302.13564653
8Biosynthesis of amino acids_Homo sapiens_hsa012302.08127164
9Chronic myeloid leukemia_Homo sapiens_hsa052202.05428875
10Galactose metabolism_Homo sapiens_hsa000521.87999956
11Fructose and mannose metabolism_Homo sapiens_hsa000511.87917824
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.76355257
13DNA replication_Homo sapiens_hsa030301.73440611
14Sulfur relay system_Homo sapiens_hsa041221.73242393
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.72887334
16Thyroid cancer_Homo sapiens_hsa052161.71517813
17Taste transduction_Homo sapiens_hsa047421.70188066
18Axon guidance_Homo sapiens_hsa043601.65033703
19Serotonergic synapse_Homo sapiens_hsa047261.63154250
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.62362645
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.60408333
22Small cell lung cancer_Homo sapiens_hsa052221.60312500
23Olfactory transduction_Homo sapiens_hsa047401.58640264
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.53705143
25Morphine addiction_Homo sapiens_hsa050321.51980779
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51858412
27Primary immunodeficiency_Homo sapiens_hsa053401.51740481
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47977703
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.41751118
30Non-small cell lung cancer_Homo sapiens_hsa052231.40044290
31Nicotine addiction_Homo sapiens_hsa050331.39998957
32VEGF signaling pathway_Homo sapiens_hsa043701.38654736
33Pancreatic cancer_Homo sapiens_hsa052121.38374219
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38368530
35Base excision repair_Homo sapiens_hsa034101.35778494
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35460065
37Carbon metabolism_Homo sapiens_hsa012001.33762323
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31780574
39Autoimmune thyroid disease_Homo sapiens_hsa053201.31302082
40Vibrio cholerae infection_Homo sapiens_hsa051101.30409898
41Lysosome_Homo sapiens_hsa041421.29253420
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27864117
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27447692
44Endometrial cancer_Homo sapiens_hsa052131.26034592
45Glutamatergic synapse_Homo sapiens_hsa047241.25890984
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25080394
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25064575
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21169044
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19902452
50T cell receptor signaling pathway_Homo sapiens_hsa046601.18087488
51N-Glycan biosynthesis_Homo sapiens_hsa005101.16795508
52Circadian entrainment_Homo sapiens_hsa047131.14983138
53Asthma_Homo sapiens_hsa053101.14504282
54GABAergic synapse_Homo sapiens_hsa047271.14449757
55Ras signaling pathway_Homo sapiens_hsa040141.10213271
56Chemokine signaling pathway_Homo sapiens_hsa040621.09619646
57Prion diseases_Homo sapiens_hsa050201.06756060
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06660011
59Osteoclast differentiation_Homo sapiens_hsa043801.06273205
60Cholinergic synapse_Homo sapiens_hsa047251.06269573
61Shigellosis_Homo sapiens_hsa051311.05394154
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05111784
63Apoptosis_Homo sapiens_hsa042101.03936269
64Proteoglycans in cancer_Homo sapiens_hsa052051.03597903
65Leukocyte transendothelial migration_Homo sapiens_hsa046701.03184641
66ECM-receptor interaction_Homo sapiens_hsa045121.00267525
67Graft-versus-host disease_Homo sapiens_hsa053320.99301356
68Hematopoietic cell lineage_Homo sapiens_hsa046400.99097623
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98719324
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.98673748
71Glioma_Homo sapiens_hsa052140.98628030
72Insulin secretion_Homo sapiens_hsa049110.98033832
73Rheumatoid arthritis_Homo sapiens_hsa053230.95096937
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94886703
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.94688009
76mTOR signaling pathway_Homo sapiens_hsa041500.94105819
77Collecting duct acid secretion_Homo sapiens_hsa049660.93955022
78Viral carcinogenesis_Homo sapiens_hsa052030.93710583
79TNF signaling pathway_Homo sapiens_hsa046680.92930807
80MicroRNAs in cancer_Homo sapiens_hsa052060.91522527
81Sphingolipid metabolism_Homo sapiens_hsa006000.90759648
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.89488495
83Basal cell carcinoma_Homo sapiens_hsa052170.88436942
84Type II diabetes mellitus_Homo sapiens_hsa049300.88090144
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86586310
86Insulin signaling pathway_Homo sapiens_hsa049100.86016412
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85960159
88Calcium signaling pathway_Homo sapiens_hsa040200.85381486
89Prostate cancer_Homo sapiens_hsa052150.85074722
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84902067
91Allograft rejection_Homo sapiens_hsa053300.84840154
92Toxoplasmosis_Homo sapiens_hsa051450.83557786
93Rap1 signaling pathway_Homo sapiens_hsa040150.82787601
94Hepatitis C_Homo sapiens_hsa051600.82609778
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.82520080
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82185683
97Oxytocin signaling pathway_Homo sapiens_hsa049210.81930162
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81776188
99Endocytosis_Homo sapiens_hsa041440.81219495
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81185829
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79513292
102Salivary secretion_Homo sapiens_hsa049700.79277573
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78838934
104AMPK signaling pathway_Homo sapiens_hsa041520.77955194
105Melanoma_Homo sapiens_hsa052180.77763347
106Lysine degradation_Homo sapiens_hsa003100.77038916
107Dopaminergic synapse_Homo sapiens_hsa047280.75857920
108Measles_Homo sapiens_hsa051620.75592234
109Vitamin B6 metabolism_Homo sapiens_hsa007500.75422668
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75146604
111Pyrimidine metabolism_Homo sapiens_hsa002400.74507103
112Cocaine addiction_Homo sapiens_hsa050300.74301121
113Ribosome_Homo sapiens_hsa030100.73907705
114Gastric acid secretion_Homo sapiens_hsa049710.73775548
115MAPK signaling pathway_Homo sapiens_hsa040100.73069381
116Wnt signaling pathway_Homo sapiens_hsa043100.73006583
117Leishmaniasis_Homo sapiens_hsa051400.72981808
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72486366
119Amoebiasis_Homo sapiens_hsa051460.72447692
120Hepatitis B_Homo sapiens_hsa051610.72162835
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69769575
122Focal adhesion_Homo sapiens_hsa045100.69536386
123Arachidonic acid metabolism_Homo sapiens_hsa005900.69166100
124B cell receptor signaling pathway_Homo sapiens_hsa046620.69069790
125cAMP signaling pathway_Homo sapiens_hsa040240.68531380
126Renin secretion_Homo sapiens_hsa049240.66666420
127Tight junction_Homo sapiens_hsa045300.66301901
128Renal cell carcinoma_Homo sapiens_hsa052110.66162954
129HTLV-I infection_Homo sapiens_hsa051660.64969516
130Spliceosome_Homo sapiens_hsa030400.64846997
131Pathways in cancer_Homo sapiens_hsa052000.63836353
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63773368
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63167205
134Protein digestion and absorption_Homo sapiens_hsa049740.62284447
135Colorectal cancer_Homo sapiens_hsa052100.61898556
136Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61870545
137Platelet activation_Homo sapiens_hsa046110.61522336
138Cell cycle_Homo sapiens_hsa041100.61030831
139Acute myeloid leukemia_Homo sapiens_hsa052210.60982497
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60728267
141ErbB signaling pathway_Homo sapiens_hsa040120.59814427
142Inositol phosphate metabolism_Homo sapiens_hsa005620.59756272
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59567702
144Ether lipid metabolism_Homo sapiens_hsa005650.59179246
145Adherens junction_Homo sapiens_hsa045200.59146107
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.58866521
147Malaria_Homo sapiens_hsa051440.58863021
148p53 signaling pathway_Homo sapiens_hsa041150.58353812
149Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57903389
150Tuberculosis_Homo sapiens_hsa051520.57578352
151Salmonella infection_Homo sapiens_hsa051320.57513967
152Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57061121
153GnRH signaling pathway_Homo sapiens_hsa049120.56898126
154Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56379499
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.56359495
156Long-term depression_Homo sapiens_hsa047300.56263305
157Notch signaling pathway_Homo sapiens_hsa043300.55716656
158Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55699540
159Pancreatic secretion_Homo sapiens_hsa049720.55675867
160Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55039441
161Hippo signaling pathway_Homo sapiens_hsa043900.54973876
162RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54542926
163Melanogenesis_Homo sapiens_hsa049160.54327915
164HIF-1 signaling pathway_Homo sapiens_hsa040660.53480560
165Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49297634
166Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49011550
167Adipocytokine signaling pathway_Homo sapiens_hsa049200.46211118
168Prolactin signaling pathway_Homo sapiens_hsa049170.45923821
169mRNA surveillance pathway_Homo sapiens_hsa030150.44224716
170Choline metabolism in cancer_Homo sapiens_hsa052310.42250900
171Epstein-Barr virus infection_Homo sapiens_hsa051690.40385884
172Estrogen signaling pathway_Homo sapiens_hsa049150.37362632
173Glutathione metabolism_Homo sapiens_hsa004800.37264744
174Influenza A_Homo sapiens_hsa051640.36189105

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