UNC50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.65032915
2signal peptide processing (GO:0006465)5.07100108
3L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.69170757
4proteasome assembly (GO:0043248)4.65986980
5chaperone-mediated protein transport (GO:0072321)4.61001886
6regulation of female gonad development (GO:2000194)4.41803305
7water-soluble vitamin biosynthetic process (GO:0042364)4.41716812
8cullin deneddylation (GO:0010388)4.29881969
9attachment of spindle microtubules to kinetochore (GO:0008608)4.20896780
10regulation of RIG-I signaling pathway (GO:0039535)4.13716566
11lactate metabolic process (GO:0006089)4.01838609
12negative regulation of execution phase of apoptosis (GO:1900118)3.91910706
13mitochondrial respiratory chain complex assembly (GO:0033108)3.86772997
14DNA double-strand break processing (GO:0000729)3.83285898
15female gamete generation (GO:0007292)3.83171872
16branched-chain amino acid catabolic process (GO:0009083)3.81206959
17regulation of meiosis (GO:0040020)3.79351061
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.78093587
19regulation of cellular amino acid metabolic process (GO:0006521)3.71331504
20L-methionine salvage (GO:0071267)3.67933798
21L-methionine biosynthetic process (GO:0071265)3.67933798
22amino acid salvage (GO:0043102)3.67933798
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.66090784
24regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.66035193
25exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.62191252
26meiotic cell cycle (GO:0051321)3.61112107
27glycerophospholipid catabolic process (GO:0046475)3.57799798
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.57551033
29maturation of 5.8S rRNA (GO:0000460)3.57521839
30platelet dense granule organization (GO:0060155)3.51860037
31piRNA metabolic process (GO:0034587)3.51823360
32respiratory chain complex IV assembly (GO:0008535)3.50353287
33mitotic metaphase plate congression (GO:0007080)3.48969917
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.48612405
35GPI anchor biosynthetic process (GO:0006506)3.48249626
36cholesterol biosynthetic process (GO:0006695)3.41781386
37preassembly of GPI anchor in ER membrane (GO:0016254)3.39569476
38CENP-A containing nucleosome assembly (GO:0034080)3.38308352
397-methylguanosine mRNA capping (GO:0006370)3.37738509
40regulation of glucokinase activity (GO:0033131)3.37404414
41regulation of hexokinase activity (GO:1903299)3.37404414
42RNA capping (GO:0036260)3.35891367
437-methylguanosine RNA capping (GO:0009452)3.35891367
44protein deneddylation (GO:0000338)3.27837792
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26739207
46regulation of mitochondrial translation (GO:0070129)3.25950892
47regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.25940502
48sterol biosynthetic process (GO:0016126)3.25009685
49signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.17234975
50signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.17234975
51signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.17234975
52response to misfolded protein (GO:0051788)3.16055796
53sphingosine metabolic process (GO:0006670)3.15907012
54signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.14512099
55intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.14512099
56histone mRNA metabolic process (GO:0008334)3.14349195
57protein K6-linked ubiquitination (GO:0085020)3.12265815
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.10805274
59regulation of metalloenzyme activity (GO:0048552)3.10394980
60protein localization to mitochondrion (GO:0070585)3.09188003
61chromatin remodeling at centromere (GO:0031055)3.07766799
62pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.04437791
63positive regulation of ligase activity (GO:0051351)3.00719880
64protein neddylation (GO:0045116)3.00201724
65establishment of protein localization to mitochondrion (GO:0072655)3.00003308
66pteridine-containing compound biosynthetic process (GO:0042559)2.99375058
67negative regulation of meiotic cell cycle (GO:0051447)2.98950499
68xenobiotic catabolic process (GO:0042178)2.98710048
69signal transduction involved in DNA damage checkpoint (GO:0072422)2.98229801
70signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98229801
71tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98210916
72RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98210916
73transcription elongation from RNA polymerase II promoter (GO:0006368)2.96919063
74signal transduction involved in cell cycle checkpoint (GO:0072395)2.96568460
75regulation of meiotic cell cycle (GO:0051445)2.96080210
76energy coupled proton transport, down electrochemical gradient (GO:0015985)2.95136054
77ATP synthesis coupled proton transport (GO:0015986)2.95136054
78respiratory electron transport chain (GO:0022904)2.93532657
79C-terminal protein amino acid modification (GO:0018410)2.92711897
80intraciliary transport (GO:0042073)2.91887829
81positive regulation of mitochondrial fission (GO:0090141)2.91856907
82dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.91076098
83ribosome assembly (GO:0042255)2.90997919
84amyloid precursor protein catabolic process (GO:0042987)2.89756205
85mitochondrial respiratory chain complex I assembly (GO:0032981)2.89298056
86NADH dehydrogenase complex assembly (GO:0010257)2.89298056
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89298056
88GPI anchor metabolic process (GO:0006505)2.88360170
89axon ensheathment in central nervous system (GO:0032291)2.88352000
90central nervous system myelination (GO:0022010)2.88352000
91diol metabolic process (GO:0034311)2.88011254
92DNA integration (GO:0015074)2.87801770
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86904130
94metaphase plate congression (GO:0051310)2.86688732
95response to nitrosative stress (GO:0051409)2.86570946
96positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.86465324
97S-adenosylmethionine metabolic process (GO:0046500)2.86457268
98electron transport chain (GO:0022900)2.86268470
99GDP-mannose metabolic process (GO:0019673)2.85585485
100mitochondrial DNA replication (GO:0006264)2.84655916
101regulation of mitotic spindle checkpoint (GO:1903504)2.84064652
102regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84064652
103regulation of DNA methylation (GO:0044030)2.83189416
104regulation of histone H3-K27 methylation (GO:0061085)2.83038705
105phosphatidylinositol acyl-chain remodeling (GO:0036149)2.82601946
106multicellular organismal aging (GO:0010259)2.82297628
107ubiquinone metabolic process (GO:0006743)2.81829514
108branched-chain amino acid metabolic process (GO:0009081)2.81246273
109mitochondrial calcium ion transport (GO:0006851)2.79538386
110response to redox state (GO:0051775)2.79358205
111synapsis (GO:0007129)2.76927457
112histone H2A acetylation (GO:0043968)2.75688550
113DNA damage response, detection of DNA damage (GO:0042769)2.75203123
114protein K11-linked ubiquitination (GO:0070979)2.75075935
115antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.74875959
116protein complex biogenesis (GO:0070271)2.74286513
117sphingoid metabolic process (GO:0046519)2.74172087
118negative regulation of meiosis (GO:0045835)2.74036259
119deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.72299656
120ubiquinone biosynthetic process (GO:0006744)2.71866507
121positive regulation of megakaryocyte differentiation (GO:0045654)2.71373659
122establishment of chromosome localization (GO:0051303)2.71148131
123DNA replication-independent nucleosome assembly (GO:0006336)2.70686719
124DNA replication-independent nucleosome organization (GO:0034724)2.70686719
125regulation of exit from mitosis (GO:0007096)2.70038791
126dopamine transport (GO:0015872)2.69638353
127aldehyde catabolic process (GO:0046185)2.69448566
128cellular protein catabolic process (GO:0044257)2.69103040
129DNA catabolic process, exonucleolytic (GO:0000738)2.68251752
130pseudouridine synthesis (GO:0001522)2.67679643
131fatty acid elongation (GO:0030497)2.67592060
132termination of RNA polymerase III transcription (GO:0006386)2.67511348
133transcription elongation from RNA polymerase III promoter (GO:0006385)2.67511348
134replication fork processing (GO:0031297)2.66789647
135regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.65922032
136regulation of ubiquitin-protein transferase activity (GO:0051438)2.65198292
137cytochrome complex assembly (GO:0017004)2.64298790
138negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.63508201
139misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.61555697
140C-terminal protein lipidation (GO:0006501)2.61082298
141regulation of autophagic vacuole assembly (GO:2000785)2.60363638
142negative regulation of DNA-templated transcription, elongation (GO:0032785)2.59584503
143negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.59584503
144antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.58900580
145negative regulation of smooth muscle cell differentiation (GO:0051151)2.57908228
146folic acid-containing compound biosynthetic process (GO:0009396)2.56966203
147rRNA modification (GO:0000154)2.56721843
148DNA replication checkpoint (GO:0000076)2.56187015
149positive regulation of cellular amine metabolic process (GO:0033240)2.54201864
150positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.53131703
151mannosylation (GO:0097502)2.51986165
152regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.51523205
153iron-sulfur cluster assembly (GO:0016226)2.51426487
154metallo-sulfur cluster assembly (GO:0031163)2.51426487
155magnesium ion transport (GO:0015693)2.49668030
156negative regulation of ligase activity (GO:0051352)2.49657954
157negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.49657954
158nucleotide transmembrane transport (GO:1901679)2.48907248
159regulation of steroid hormone secretion (GO:2000831)2.48220727
160peptidyl-histidine modification (GO:0018202)2.47957007
161protein targeting to mitochondrion (GO:0006626)2.47896768
162protein maturation by protein folding (GO:0022417)2.47481170
163histone exchange (GO:0043486)2.47467261

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.62704928
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.52108666
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.75730279
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.34549987
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.20464353
6CREB1_15753290_ChIP-ChIP_HEK293T_Human2.89233529
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.79917276
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68078559
9VDR_23849224_ChIP-Seq_CD4+_Human2.62337573
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.58998435
11PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.55946153
12* SRF_21415370_ChIP-Seq_HL-1_Mouse2.46340534
13FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.44481486
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43909193
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.40830774
16E2F1_18555785_ChIP-Seq_MESCs_Mouse2.26769236
17GABP_19822575_ChIP-Seq_HepG2_Human2.26486595
18KAP1_22055183_ChIP-Seq_ESCs_Mouse2.23153469
19* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.23110616
20ZNF274_21170338_ChIP-Seq_K562_Hela2.10508555
21DCP1A_22483619_ChIP-Seq_HELA_Human2.09754703
22HOXB4_20404135_ChIP-ChIP_EML_Mouse2.09287967
23* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07927447
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.06366822
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05662737
26PADI4_21655091_ChIP-ChIP_MCF-7_Human2.04822664
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.04127745
28AR_21909140_ChIP-Seq_LNCAP_Human2.01169296
29ERG_20887958_ChIP-Seq_HPC-7_Mouse1.98021127
30* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.97247341
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94190852
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91644570
33EWS_26573619_Chip-Seq_HEK293_Human1.91058828
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89243153
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88246800
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82017478
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76413270
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73022542
39* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72676118
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.69558873
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67782308
42FOXP3_21729870_ChIP-Seq_TREG_Human1.67381828
43VDR_22108803_ChIP-Seq_LS180_Human1.66711899
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63781825
45FUS_26573619_Chip-Seq_HEK293_Human1.62022155
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60651011
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.58990241
48* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58020540
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55361611
50TAF15_26573619_Chip-Seq_HEK293_Human1.54894964
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54113017
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.51381806
53ELK1_19687146_ChIP-ChIP_HELA_Human1.50898523
54* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49476576
55MYC_18940864_ChIP-ChIP_HL60_Human1.49127682
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48815256
57P300_19829295_ChIP-Seq_ESCs_Human1.47692038
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46455119
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45737118
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.38397133
61E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.37403908
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37388778
63SPI1_23547873_ChIP-Seq_NB4_Human1.36008185
64* EZH2_27294783_Chip-Seq_NPCs_Mouse1.34080973
65* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33282445
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32192768
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31888478
68ERG_20517297_ChIP-Seq_VCAP_Human1.30442550
69TBX5_21415370_ChIP-Seq_HL-1_Mouse1.28049352
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27164449
71XRN2_22483619_ChIP-Seq_HELA_Human1.25910712
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21309616
73* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21028488
74LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20377831
75* NFE2_27457419_Chip-Seq_LIVER_Mouse1.18550779
76* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18094767
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17693666
78* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16536812
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15313109
80TTF2_22483619_ChIP-Seq_HELA_Human1.13998672
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13859924
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13513614
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13475168
84E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12562295
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12046338
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11056130
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10207537
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10044085
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08024195
90TFEB_21752829_ChIP-Seq_HELA_Human1.07827685
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.07192422
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07171147
93GBX2_23144817_ChIP-Seq_PC3_Human1.06945775
94* CRX_20693478_ChIP-Seq_RETINA_Mouse1.06387164
95NANOG_19829295_ChIP-Seq_ESCs_Human1.06013194
96SOX2_19829295_ChIP-Seq_ESCs_Human1.06013194
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05316072
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04804471
99CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04659580
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04399042
101* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03521720
102ER_23166858_ChIP-Seq_MCF-7_Human1.02858566
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02560410
104NANOG_20526341_ChIP-Seq_ESCs_Human1.00390900
105FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98912403
106FOXA1_25329375_ChIP-Seq_VCAP_Human0.98912403
107KDM5A_27292631_Chip-Seq_BREAST_Human0.98429626
108TP53_22573176_ChIP-Seq_HFKS_Human0.97750463
109* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97654486
110PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97179316
111AR_20517297_ChIP-Seq_VCAP_Human0.96603296
112CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96138226
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96061759
114HTT_18923047_ChIP-ChIP_STHdh_Human0.95562221
115* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95227902
116* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94882952
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93604738
118IGF1R_20145208_ChIP-Seq_DFB_Human0.93574903
119KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93027062
120MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92903728
121EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92899437
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92827286
123NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92577824
124SMAD_19615063_ChIP-ChIP_OVARY_Human0.92542771
125MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92325155
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90472816
127* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90355133
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90137035
129CBP_20019798_ChIP-Seq_JUKART_Human0.90137035
130* SALL4_22934838_ChIP-ChIP_CD34+_Human0.89941012
131AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89812145
132PIAS1_25552417_ChIP-Seq_VCAP_Human0.89806239
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89694459
134CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89663017
135MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89578297
136CDX2_22108803_ChIP-Seq_LS180_Human0.88831248
137YY1_21170310_ChIP-Seq_MESCs_Mouse0.87571365
138POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87486744
139TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86478570
140CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86037076
141E2F1_21310950_ChIP-Seq_MCF-7_Human0.85925112
142* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85825345
143* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85606316
144* FLI1_27457419_Chip-Seq_LIVER_Mouse0.85075461
145REST_19997604_ChIP-ChIP_NEURONS_Mouse0.83673814
146* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82965488
147FOXA1_21572438_ChIP-Seq_LNCaP_Human0.80013800
148CTCF_18555785_ChIP-Seq_MESCs_Mouse0.79920806
149TAL1_26923725_Chip-Seq_HPCs_Mouse0.79890645
150IRF8_22096565_ChIP-ChIP_GC-B_Human0.79244817
151NOTCH1_21737748_ChIP-Seq_TLL_Human0.79177326
152* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78881009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect4.68683633
2MP0005451_abnormal_body_composition4.35739710
3MP0003693_abnormal_embryo_hatching3.03587670
4MP0002102_abnormal_ear_morphology3.00410588
5MP0005408_hypopigmentation2.82025679
6MP0009840_abnormal_foam_cell2.79367518
7MP0008058_abnormal_DNA_repair2.77753805
8MP0001984_abnormal_olfaction2.55109256
9MP0003806_abnormal_nucleotide_metabolis2.44172467
10MP0004957_abnormal_blastocyst_morpholog2.42962814
11MP0003186_abnormal_redox_activity2.42014687
12MP0003011_delayed_dark_adaptation2.40779809
13MP0003724_increased_susceptibility_to2.33688401
14MP0003646_muscle_fatigue2.32473362
15MP0008260_abnormal_autophagy2.29156672
16MP0001905_abnormal_dopamine_level2.28378228
17MP0002653_abnormal_ependyma_morphology2.23222892
18MP0003656_abnormal_erythrocyte_physiolo2.17242184
19MP0001529_abnormal_vocalization2.14982849
20MP0005310_abnormal_salivary_gland2.10184725
21MP0005395_other_phenotype2.09106248
22MP0000516_abnormal_urinary_system2.01257795
23MP0005367_renal/urinary_system_phenotyp2.01257795
24MP0003786_premature_aging1.95355483
25MP0005379_endocrine/exocrine_gland_phen1.95323364
26MP0002139_abnormal_hepatobiliary_system1.94969921
27MP0001764_abnormal_homeostasis1.92570676
28MP0008789_abnormal_olfactory_epithelium1.91745859
29MP0004147_increased_porphyrin_level1.88948917
30MP0005253_abnormal_eye_physiology1.85105195
31MP0003122_maternal_imprinting1.84543527
32MP0010234_abnormal_vibrissa_follicle1.83659641
33MP0009333_abnormal_splenocyte_physiolog1.79111138
34MP0003077_abnormal_cell_cycle1.76256965
35MP0005058_abnormal_lysosome_morphology1.74939063
36MP0006035_abnormal_mitochondrial_morpho1.74937144
37MP0002090_abnormal_vision1.74234166
38MP0005394_taste/olfaction_phenotype1.72267195
39MP0005499_abnormal_olfactory_system1.72267195
40MP0010386_abnormal_urinary_bladder1.68753563
41MP0009785_altered_susceptibility_to1.66279789
42MP0001119_abnormal_female_reproductive1.65611589
43MP0008932_abnormal_embryonic_tissue1.64309727
44MP0000462_abnormal_digestive_system1.64218481
45MP0008875_abnormal_xenobiotic_pharmacok1.61765958
46MP0002938_white_spotting1.60238135
47MP0003329_amyloid_beta_deposits1.57044659
48MP0005220_abnormal_exocrine_pancreas1.56369294
49MP0010094_abnormal_chromosome_stability1.55916326
50MP0004043_abnormal_pH_regulation1.54375796
51MP0002254_reproductive_system_inflammat1.52348825
52MP0003890_abnormal_embryonic-extraembry1.52172450
53MP0005671_abnormal_response_to1.52048533
54MP0000920_abnormal_myelination1.46878404
55MP0003699_abnormal_female_reproductive1.46284338
56MP0005332_abnormal_amino_acid1.44556708
57MP0000490_abnormal_crypts_of1.44214924
58MP0008007_abnormal_cellular_replicative1.42533111
59MP0006292_abnormal_olfactory_placode1.41668205
60MP0003195_calcinosis1.41647002
61MP0006082_CNS_inflammation1.38762740
62MP0004133_heterotaxia1.38460988
63MP0003950_abnormal_plasma_membrane1.36930367
64MP0000685_abnormal_immune_system1.36000909
65MP0000647_abnormal_sebaceous_gland1.34633512
66MP0009384_cardiac_valve_regurgitation1.34307388
67MP0000653_abnormal_sex_gland1.34272584
68MP0003121_genomic_imprinting1.32185890
69MP0004264_abnormal_extraembryonic_tissu1.31856521
70MP0001929_abnormal_gametogenesis1.31064282
71MP0008877_abnormal_DNA_methylation1.30085399
72MP0001293_anophthalmia1.29817130
73MP0002233_abnormal_nose_morphology1.28840469
74MP0006072_abnormal_retinal_apoptosis1.28688041
75MP0002163_abnormal_gland_morphology1.26651641
76MP0006036_abnormal_mitochondrial_physio1.26569126
77MP0002837_dystrophic_cardiac_calcinosis1.24205923
78MP0002693_abnormal_pancreas_physiology1.23685978
79MP0003567_abnormal_fetal_cardiomyocyte1.22737886
80MP0003787_abnormal_imprinting1.22681697
81MP0002277_abnormal_respiratory_mucosa1.21288293
82MP0003283_abnormal_digestive_organ1.20042034
83MP0003111_abnormal_nucleus_morphology1.19860452
84MP0003763_abnormal_thymus_physiology1.18665341
85MP0000372_irregular_coat_pigmentation1.18595072
86MP0000639_abnormal_adrenal_gland1.17668980
87MP0002877_abnormal_melanocyte_morpholog1.17529393
88MP0008995_early_reproductive_senescence1.16938967
89MP0005551_abnormal_eye_electrophysiolog1.15573983
90MP0009046_muscle_twitch1.15169021
91MP0005365_abnormal_bile_salt1.15091573
92MP0005084_abnormal_gallbladder_morpholo1.14870475
93MP0000613_abnormal_salivary_gland1.14126541
94MP0002148_abnormal_hypersensitivity_rea1.13582896
95MP0005075_abnormal_melanosome_morpholog1.13139815
96MP0002295_abnormal_pulmonary_circulatio1.12489158
97MP0003252_abnormal_bile_duct1.11972368
98MP0002933_joint_inflammation1.11807160
99MP0005248_abnormal_Harderian_gland1.10804859
100MP0000358_abnormal_cell_content/1.09548419
101MP0005000_abnormal_immune_tolerance1.08793177
102MP0002210_abnormal_sex_determination1.07570197
103MP0001944_abnormal_pancreas_morphology1.07197146
104MP0002638_abnormal_pupillary_reflex1.02460946
105MP0005636_abnormal_mineral_homeostasis1.00552134
106MP0001986_abnormal_taste_sensitivity1.00381157
107MP0003937_abnormal_limbs/digits/tail_de1.00051165
108MP0001851_eye_inflammation0.99570369
109MP0002419_abnormal_innate_immunity0.98666278
110MP0004215_abnormal_myocardial_fiber0.97294215
111MP0000343_altered_response_to0.96240771
112MP0002736_abnormal_nociception_after0.95595638
113MP0009697_abnormal_copulation0.95437787
114MP0010678_abnormal_skin_adnexa0.95409547
115MP0002723_abnormal_immune_serum0.95288084
116MP0003221_abnormal_cardiomyocyte_apopto0.94182525
117MP0005389_reproductive_system_phenotype0.93733189
118MP0004019_abnormal_vitamin_homeostasis0.92760621
119MP0001835_abnormal_antigen_presentation0.92148600
120MP0000604_amyloidosis0.91888230
121MP0010368_abnormal_lymphatic_system0.91742778
122MP0002234_abnormal_pharynx_morphology0.90789653
123MP0003941_abnormal_skin_development0.89676398
124MP0002019_abnormal_tumor_incidence0.88406069
125MP0002160_abnormal_reproductive_system0.87729587
126MP0005025_abnormal_response_to0.87080167
127MP0001533_abnormal_skeleton_physiology0.86373576
128MP0003183_abnormal_peptide_metabolism0.85187474
129MP0005085_abnormal_gallbladder_physiolo0.84894034
130MP0003136_yellow_coat_color0.84414769
131MP0003119_abnormal_digestive_system0.83558560
132MP0000465_gastrointestinal_hemorrhage0.83137031
133MP0004142_abnormal_muscle_tone0.82933563
134MP0005391_vision/eye_phenotype0.81189104
135MP0001145_abnormal_male_reproductive0.80583957
136MP0001756_abnormal_urination0.80070260
137MP0002452_abnormal_antigen_presenting0.78971757
138MP0001819_abnormal_immune_cell0.78001016
139MP0002420_abnormal_adaptive_immunity0.77933256
140MP0000427_abnormal_hair_cycle0.76624132
141MP0002909_abnormal_adrenal_gland0.75769058
142MP0002405_respiratory_system_inflammati0.75222303
143MP0000579_abnormal_nail_morphology0.72475183
144MP0010329_abnormal_lipoprotein_level0.72426700
145MP0005645_abnormal_hypothalamus_physiol0.71113669
146MP0002161_abnormal_fertility/fecundity0.70986221
147MP0001324_abnormal_eye_pigmentation0.70314551
148MP0005390_skeleton_phenotype0.70055209
149MP0001845_abnormal_inflammatory_respons0.69622328
150MP0000689_abnormal_spleen_morphology0.69421825
151MP0005381_digestive/alimentary_phenotyp0.68967064
152MP0006054_spinal_hemorrhage0.67973715
153MP0008469_abnormal_protein_level0.67861408
154MP0000716_abnormal_immune_system0.66128367
155MP0003436_decreased_susceptibility_to0.66123707
156MP0009643_abnormal_urine_homeostasis0.65995758
157MP0002138_abnormal_hepatobiliary_system0.65170989
158MP0004185_abnormal_adipocyte_glucose0.64959131
159MP0008872_abnormal_physiological_respon0.64186428
160MP0005187_abnormal_penis_morphology0.63908504
161MP0002398_abnormal_bone_marrow0.63228425
162MP0005164_abnormal_response_to0.60614427

Predicted human phenotypes

RankGene SetZ-score
1Decreased activity of mitochondrial respiratory chain (HP:0008972)3.89472346
2Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.89472346
3Male infertility (HP:0003251)3.87699487
4Aplastic anemia (HP:0001915)3.51788260
5Flat capital femoral epiphysis (HP:0003370)3.47964789
6Hepatocellular necrosis (HP:0001404)3.43611151
7Hyperinsulinemic hypoglycemia (HP:0000825)3.40945772
8Hyperglycinemia (HP:0002154)3.37152397
9Hypothermia (HP:0002045)3.34587244
10Birth length less than 3rd percentile (HP:0003561)3.28328433
11Hepatic necrosis (HP:0002605)3.25159318
12Hypoglycemic seizures (HP:0002173)3.17287182
13Cerebral hypomyelination (HP:0006808)3.14044616
14Type I transferrin isoform profile (HP:0003642)3.12996260
15Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.08215512
16Abnormal protein N-linked glycosylation (HP:0012347)3.08215512
17Abnormal protein glycosylation (HP:0012346)3.08215512
18Abnormal glycosylation (HP:0012345)3.08215512
19Cerebral edema (HP:0002181)3.03415476
20Exertional dyspnea (HP:0002875)3.03302390
213-Methylglutaconic aciduria (HP:0003535)3.01613523
22Hypoglycemic coma (HP:0001325)3.00335578
23Secondary amenorrhea (HP:0000869)2.98857924
24Acute necrotizing encephalopathy (HP:0006965)2.96898409
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.91351326
26Abnormality of alanine metabolism (HP:0010916)2.91351326
27Hyperalaninemia (HP:0003348)2.91351326
28Breast hypoplasia (HP:0003187)2.89532277
29Mitochondrial inheritance (HP:0001427)2.89358868
30Increased hepatocellular lipid droplets (HP:0006565)2.84187641
31Abnormal mitochondria in muscle tissue (HP:0008316)2.81054919
32Increased serum pyruvate (HP:0003542)2.77986155
33Renal Fanconi syndrome (HP:0001994)2.75756857
34Lipid accumulation in hepatocytes (HP:0006561)2.73785829
35Medial flaring of the eyebrow (HP:0010747)2.72547660
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.70797119
37Increased intramyocellular lipid droplets (HP:0012240)2.69479402
38Acute encephalopathy (HP:0006846)2.68044235
39Irregular epiphyses (HP:0010582)2.65559757
40Progressive neurologic deterioration (HP:0002344)2.62158048
41Cerebellar dysplasia (HP:0007033)2.55577187
42Ketoacidosis (HP:0001993)2.52991011
43Adrenal hypoplasia (HP:0000835)2.51986485
44Abnormality of vitamin B metabolism (HP:0004340)2.50344925
45Reduced antithrombin III activity (HP:0001976)2.49877184
46Congenital primary aphakia (HP:0007707)2.42869884
47Pancreatic cysts (HP:0001737)2.42847371
48Pancreatic islet-cell hyperplasia (HP:0004510)2.42015795
49Hypergonadotropic hypogonadism (HP:0000815)2.41551603
50Neurofibrillary tangles (HP:0002185)2.41480444
51Pulmonary fibrosis (HP:0002206)2.38958930
52Lethargy (HP:0001254)2.37436470
53Increased muscle lipid content (HP:0009058)2.37146600
54Exercise intolerance (HP:0003546)2.35915698
55Abnormality of glycine metabolism (HP:0010895)2.34747710
56Abnormality of serine family amino acid metabolism (HP:0010894)2.34747710
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33860456
58Abnormality of the vitamin B12 metabolism (HP:0004341)2.33733403
59CNS hypomyelination (HP:0003429)2.33656434
60Increased CSF lactate (HP:0002490)2.33315181
61Prominent metopic ridge (HP:0005487)2.32604923
62Retinal dysplasia (HP:0007973)2.31288992
63Vacuolated lymphocytes (HP:0001922)2.30452234
64Microretrognathia (HP:0000308)2.28112220
65Abnormality of glycolysis (HP:0004366)2.27499165
66Poor head control (HP:0002421)2.27464979
67Symptomatic seizures (HP:0011145)2.27373035
68Carpal bone hypoplasia (HP:0001498)2.27315861
69Abnormality of aromatic amino acid family metabolism (HP:0004338)2.27016412
70Abnormality of serum amino acid levels (HP:0003112)2.26728907
71Abnormality of the metopic suture (HP:0005556)2.25043231
72Oral leukoplakia (HP:0002745)2.23137675
73Nephrogenic diabetes insipidus (HP:0009806)2.23131270
74Short tibia (HP:0005736)2.22708696
75Gait imbalance (HP:0002141)2.21974182
76Type 2 muscle fiber atrophy (HP:0003554)2.21565674
77Type II lissencephaly (HP:0007260)2.21223693
78True hermaphroditism (HP:0010459)2.20094908
79Microvesicular hepatic steatosis (HP:0001414)2.19501072
80Parakeratosis (HP:0001036)2.19366942
81Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.17803027
82Neoplasm of the adrenal gland (HP:0100631)2.15287624
83Nonprogressive disorder (HP:0003680)2.13646039
84Aplasia/hypoplasia of the uterus (HP:0008684)2.12430004
85Hypoplasia of the uterus (HP:0000013)2.12249864
86Increased serum lactate (HP:0002151)2.11214488
87Abnormality of the labia minora (HP:0012880)2.09980897
88Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09428035
89Dicarboxylic aciduria (HP:0003215)2.09379697
90Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09379697
91Bile duct proliferation (HP:0001408)2.08665083
92Abnormal biliary tract physiology (HP:0012439)2.08665083
93Gonadotropin excess (HP:0000837)2.07280481
94Progressive macrocephaly (HP:0004481)2.06786041
95Hypomagnesemia (HP:0002917)2.06641916
96Lactic acidosis (HP:0003128)2.05421490
97Rough bone trabeculation (HP:0100670)2.04974367
98Abnormality of the pancreatic islet cells (HP:0006476)2.04690693
99Abnormality of endocrine pancreas physiology (HP:0012093)2.04690693
100Postnatal microcephaly (HP:0005484)2.02934234
101Methylmalonic aciduria (HP:0012120)2.02926893
102Genital tract atresia (HP:0001827)2.02416937
103Delayed CNS myelination (HP:0002188)2.01300656
104Abnormality of placental membranes (HP:0011409)2.00757257
105Amniotic constriction ring (HP:0009775)2.00757257
106Tubulointerstitial nephritis (HP:0001970)1.99681796
107Abnormality of the pons (HP:0007361)1.99548526
108Abnormality of the femoral head (HP:0003368)1.99265831
109Vaginal atresia (HP:0000148)1.99133126
110Spastic paraparesis (HP:0002313)1.97997838
111Nephronophthisis (HP:0000090)1.97577317
112Methylmalonic acidemia (HP:0002912)1.97541676
113Intestinal atresia (HP:0011100)1.97459384
114Aplasia/Hypoplasia of the fovea (HP:0008060)1.97282590
115Hypoplasia of the fovea (HP:0007750)1.97282590
116Muscle fiber atrophy (HP:0100295)1.97171521
117Bifid tongue (HP:0010297)1.95055058
118Abnormality of midbrain morphology (HP:0002418)1.93651088
119Molar tooth sign on MRI (HP:0002419)1.93651088
120Ketosis (HP:0001946)1.93052633
121Abnormal number of erythroid precursors (HP:0012131)1.91740978
122Abnormality of liposaccharide metabolism (HP:0010968)1.88993004
123Abnormality of glycosphingolipid metabolism (HP:0004343)1.88993004
124Abnormality of glycolipid metabolism (HP:0010969)1.88993004
125Supernumerary spleens (HP:0009799)1.87570658
126Generalized aminoaciduria (HP:0002909)1.87416067
127Abnormality of the epiphysis of the femoral head (HP:0010574)1.86963905
128Abnormality of urine glucose concentration (HP:0011016)1.86760811
129Glycosuria (HP:0003076)1.86760811
130Abnormality of the fovea (HP:0000493)1.86430049
131Aplasia/Hypoplasia of the tibia (HP:0005772)1.86322360
132Irregular vertebral endplates (HP:0003301)1.86097687
133Chronic sinusitis (HP:0011109)1.85346628
134Abnormality of methionine metabolism (HP:0010901)1.85254133
135CNS demyelination (HP:0007305)1.84702935
136Abnormality of the anterior horn cell (HP:0006802)1.84400981
137Degeneration of anterior horn cells (HP:0002398)1.84400981
138Abnormality of vitamin metabolism (HP:0100508)1.83925650
139Pancreatic fibrosis (HP:0100732)1.82357894
140Abnormality of the heme biosynthetic pathway (HP:0010472)1.80936377
141Hyperphosphaturia (HP:0003109)1.80535641
142Optic disc pallor (HP:0000543)1.78882339
143Palpitations (HP:0001962)1.78669570
144Abnormal spermatogenesis (HP:0008669)1.78167972
145Beaking of vertebral bodies (HP:0004568)1.77877863
146Respiratory failure (HP:0002878)1.77665785
147IgM deficiency (HP:0002850)1.77489367
148Petechiae (HP:0000967)1.76047805
149Respiratory difficulties (HP:0002880)1.74254737
150Premature ovarian failure (HP:0008209)1.73369313
151Chronic bronchitis (HP:0004469)1.72279544
152Abnormality of renal resorption (HP:0011038)1.72157479
153Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.71610966
154Abnormality of macrophages (HP:0004311)1.71574211
155Delusions (HP:0000746)1.71194157
156Abnormality of cells of the erythroid lineage (HP:0012130)1.68926403
157Abnormal trabecular bone morphology (HP:0100671)1.68191872

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MOS4.06570455
2BMPR23.91974137
3ARAF3.68888485
4TAOK33.62061137
5MAP4K23.47722512
6MUSK3.40048174
7TRIM283.06709424
8BUB12.98499924
9PLK42.93835996
10BRAF2.52043247
11FRK2.45343489
12MAP3K132.38428428
13SRPK12.32126584
14MAP3K62.26467973
15KSR22.19276788
16PBK2.18369526
17NEK12.15126656
18RAF11.94578324
19WNK31.94038438
20ACVR1B1.91518832
21CDK81.88266489
22EIF2AK11.86212270
23DYRK21.82331570
24MAPKAPK51.80194578
25NUAK11.79192470
26TESK21.77311454
27ERBB41.76743913
28GRK11.76500195
29VRK21.63365254
30ERBB31.58681718
31MKNK21.57413713
32ZAK1.57301640
33PLK31.52130294
34AKT31.50016657
35VRK11.49907905
36LIMK11.47855629
37STK161.46833451
38STK38L1.39823904
39NME21.39485293
40EIF2AK31.39474266
41PLK21.39348211
42PDK21.37654875
43CSNK1G31.36504688
44CSNK1G11.34062715
45DYRK31.31863814
46MST41.31572288
47LATS11.30703393
48LATS21.29338471
49MKNK11.29313667
50TTK1.28986162
51ABL21.26242085
52MAP3K41.24689460
53MAP3K91.24644874
54MAPKAPK31.23523804
55CDK191.18588743
56STK391.16466581
57SIK31.08359341
58TSSK61.07158926
59NLK1.03291936
60MAP3K121.02916441
61RPS6KA40.99638412
62BCKDK0.99554659
63KDR0.99110916
64KSR10.96649503
65OXSR10.96615295
66NEK90.96379694
67CSNK1G20.95822076
68CDC70.93696617
69HIPK20.86056259
70MAP2K70.85043903
71KIT0.83275138
72BMPR1B0.82862610
73EIF2AK20.82331341
74PIM20.81177795
75BRSK20.79834152
76TLK10.79337695
77TNIK0.79148542
78MAP3K80.78928098
79CDK90.77539567
80CHEK20.77302320
81CSNK1A1L0.77023767
82NEK20.76576155
83ADRBK20.74373470
84TXK0.74270832
85STK100.72044331
86CCNB10.70258118
87FGFR20.69075859
88MAPK150.68613277
89PLK10.66825432
90TESK10.66132596
91PINK10.65881231
92PIK3CA0.65047566
93STK30.63586687
94FER0.63000790
95PRKCE0.60777283
96TEC0.60748459
97MELK0.59383303
98GRK70.59253980
99MET0.58172427
100WEE10.57848968
101CAMKK20.57139695
102BCR0.56244672
103FLT30.55746713
104AURKA0.53296034
105CSNK2A10.52819657
106AURKB0.52459794
107PIK3CG0.51321368
108PAK30.50825382
109RPS6KA50.50420811
110JAK30.50261111
111IRAK40.49795180
112ATM0.48340135
113TGFBR20.48323178
114MAP3K50.46848149
115TAOK10.45689930
116PRKCI0.45164839
117PRKCG0.43720060
118PASK0.43687510
119MINK10.43622419
120CASK0.43038941
121ERN10.41795570
122BRSK10.41357377
123MAP3K10.39818618
124MAP3K110.39141119
125CSNK1A10.39012353
126MAP3K140.38305941
127TYK20.37974192
128TBK10.37395898
129PRKD30.37286462
130ZAP700.36671175
131PAK10.36163625
132PAK40.36157181
133IKBKE0.35801766
134LYN0.35794280
135CDK30.35706212
136SCYL20.35328199
137CSNK2A20.34874061
138EPHB10.33872057
139ATR0.33323264
140CAMK2D0.33216659
141MAPK130.32338561
142ABL10.29120363
143CAMK2G0.29111695
144EPHA30.27676266
145STK240.27359608
146IRAK10.27260877
147NEK60.27254475
148FGFR10.26743917
149CAMK2A0.25795449
150WNK40.25789282
151INSRR0.24615053
152NME10.22768991

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.25886350
2RNA polymerase_Homo sapiens_hsa030203.06233848
3Folate biosynthesis_Homo sapiens_hsa007903.02041006
4Propanoate metabolism_Homo sapiens_hsa006402.92272024
5Basal transcription factors_Homo sapiens_hsa030222.85775875
6Proteasome_Homo sapiens_hsa030502.61762968
7RNA degradation_Homo sapiens_hsa030182.41750726
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.31921283
9DNA replication_Homo sapiens_hsa030302.29183871
10Sulfur metabolism_Homo sapiens_hsa009202.24356584
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.23916823
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.07261702
13Homologous recombination_Homo sapiens_hsa034402.04797817
14Ether lipid metabolism_Homo sapiens_hsa005652.03258710
15Oxidative phosphorylation_Homo sapiens_hsa001902.00783294
16Pyrimidine metabolism_Homo sapiens_hsa002401.99533716
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93433116
18Cell cycle_Homo sapiens_hsa041101.92619934
19Ribosome_Homo sapiens_hsa030101.90971088
20Fatty acid elongation_Homo sapiens_hsa000621.89317593
21Linoleic acid metabolism_Homo sapiens_hsa005911.88216285
22Nucleotide excision repair_Homo sapiens_hsa034201.81717368
23Base excision repair_Homo sapiens_hsa034101.80120480
24Vitamin B6 metabolism_Homo sapiens_hsa007501.77584109
25Ovarian steroidogenesis_Homo sapiens_hsa049131.75081877
26Butanoate metabolism_Homo sapiens_hsa006501.74574373
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.66974044
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61074213
29Steroid biosynthesis_Homo sapiens_hsa001001.57825109
30Sphingolipid metabolism_Homo sapiens_hsa006001.56401622
31Parkinsons disease_Homo sapiens_hsa050121.52503703
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49328139
33Sulfur relay system_Homo sapiens_hsa041221.46083271
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45168295
35Other glycan degradation_Homo sapiens_hsa005111.43927832
36Fatty acid metabolism_Homo sapiens_hsa012121.42009902
37Mismatch repair_Homo sapiens_hsa034301.41797943
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41643543
39Circadian rhythm_Homo sapiens_hsa047101.40538884
40Pyruvate metabolism_Homo sapiens_hsa006201.35280918
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34351753
42Purine metabolism_Homo sapiens_hsa002301.33694771
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.32397176
44Huntingtons disease_Homo sapiens_hsa050161.32183388
45Non-homologous end-joining_Homo sapiens_hsa034501.31718743
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30558938
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29905802
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27761341
49Collecting duct acid secretion_Homo sapiens_hsa049661.24671289
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17254453
51Arachidonic acid metabolism_Homo sapiens_hsa005901.16155981
52Fatty acid degradation_Homo sapiens_hsa000711.13060451
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12040765
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10992021
55Alzheimers disease_Homo sapiens_hsa050101.08520662
56RNA transport_Homo sapiens_hsa030130.99323956
57N-Glycan biosynthesis_Homo sapiens_hsa005100.96318310
58Carbon metabolism_Homo sapiens_hsa012000.95994915
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91929450
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91528920
61Regulation of autophagy_Homo sapiens_hsa041400.90819814
62p53 signaling pathway_Homo sapiens_hsa041150.87144201
63Glutathione metabolism_Homo sapiens_hsa004800.86869302
64Lysosome_Homo sapiens_hsa041420.85367344
65Tryptophan metabolism_Homo sapiens_hsa003800.85276279
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84595088
67Fanconi anemia pathway_Homo sapiens_hsa034600.82823071
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82700135
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79863776
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.79201325
71Histidine metabolism_Homo sapiens_hsa003400.77068606
72Phototransduction_Homo sapiens_hsa047440.75430894
73Metabolic pathways_Homo sapiens_hsa011000.74244806
74Spliceosome_Homo sapiens_hsa030400.73793232
75beta-Alanine metabolism_Homo sapiens_hsa004100.73046605
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71393327
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68523291
78Peroxisome_Homo sapiens_hsa041460.67932348
79Oocyte meiosis_Homo sapiens_hsa041140.67678369
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67348993
81One carbon pool by folate_Homo sapiens_hsa006700.67223513
82Pentose phosphate pathway_Homo sapiens_hsa000300.66770949
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65000636
84Vibrio cholerae infection_Homo sapiens_hsa051100.64402368
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63894891
86Malaria_Homo sapiens_hsa051440.63744385
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63269071
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.61827527
89Arginine and proline metabolism_Homo sapiens_hsa003300.61762656
90Shigellosis_Homo sapiens_hsa051310.57357335
91Retinol metabolism_Homo sapiens_hsa008300.55459584
92Nitrogen metabolism_Homo sapiens_hsa009100.54834946
93Rheumatoid arthritis_Homo sapiens_hsa053230.49166778
94Pancreatic cancer_Homo sapiens_hsa052120.46435689
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46074097
96Type I diabetes mellitus_Homo sapiens_hsa049400.45598126
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45040651
98TGF-beta signaling pathway_Homo sapiens_hsa043500.45023665
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41887153
100Biosynthesis of amino acids_Homo sapiens_hsa012300.41174213
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40964336
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39866040
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37706706
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36428836
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35702574
106Mineral absorption_Homo sapiens_hsa049780.34404491
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.34361839
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.34005228
109Herpes simplex infection_Homo sapiens_hsa051680.32628060
110Vitamin digestion and absorption_Homo sapiens_hsa049770.32225282
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31969342
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.31580921
113Selenocompound metabolism_Homo sapiens_hsa004500.31380782
114Fat digestion and absorption_Homo sapiens_hsa049750.31236102
115Phagosome_Homo sapiens_hsa041450.29148867
116Hematopoietic cell lineage_Homo sapiens_hsa046400.29023761
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28470143
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27776775
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25990173
120Epstein-Barr virus infection_Homo sapiens_hsa051690.24180540
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.24103480
122Antigen processing and presentation_Homo sapiens_hsa046120.23330987
123Complement and coagulation cascades_Homo sapiens_hsa046100.22185020
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.21349057
125Legionellosis_Homo sapiens_hsa051340.20562327
126Thyroid cancer_Homo sapiens_hsa052160.16578087
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.15307004
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.13053219
129Chemical carcinogenesis_Homo sapiens_hsa052040.11639488
130Asthma_Homo sapiens_hsa053100.10090793
131Graft-versus-host disease_Homo sapiens_hsa053320.07504252
132Caffeine metabolism_Homo sapiens_hsa002320.06818852
133Renal cell carcinoma_Homo sapiens_hsa052110.06733790
134Apoptosis_Homo sapiens_hsa042100.06189167
135Pertussis_Homo sapiens_hsa051330.04435578

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