UNC5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.52244552
2synaptic vesicle maturation (GO:0016188)6.40171386
3locomotory exploration behavior (GO:0035641)6.15293841
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.87181908
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.85132694
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.36057598
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.33836985
8vocalization behavior (GO:0071625)5.30852545
9synaptic vesicle exocytosis (GO:0016079)5.29859154
10glutamate secretion (GO:0014047)5.27696101
11regulation of glutamate receptor signaling pathway (GO:1900449)5.10612825
12regulation of synaptic vesicle exocytosis (GO:2000300)5.00046005
13cerebellar granule cell differentiation (GO:0021707)4.94358935
14L-amino acid import (GO:0043092)4.88725024
15regulation of neuronal synaptic plasticity (GO:0048168)4.86341038
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.84302758
17exploration behavior (GO:0035640)4.79437801
18protein localization to synapse (GO:0035418)4.71558459
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.66094587
20regulation of synaptic vesicle transport (GO:1902803)4.57815896
21regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.56398099
22neurotransmitter secretion (GO:0007269)4.38467291
23synaptic transmission, glutamatergic (GO:0035249)4.36554663
24regulation of synapse structural plasticity (GO:0051823)4.34272453
25neuronal action potential propagation (GO:0019227)4.33730974
26amino acid import (GO:0043090)4.33168214
27dendritic spine morphogenesis (GO:0060997)4.20459613
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.18283910
29regulation of synapse maturation (GO:0090128)4.18077143
30glutamate receptor signaling pathway (GO:0007215)4.16838492
31layer formation in cerebral cortex (GO:0021819)4.12811229
32neurotransmitter-gated ion channel clustering (GO:0072578)4.10296277
33long-term memory (GO:0007616)4.07536531
34proline transport (GO:0015824)4.07284042
35neuron cell-cell adhesion (GO:0007158)4.05430573
36negative regulation of dendrite morphogenesis (GO:0050774)4.00188458
37sodium ion export (GO:0071436)3.96121948
38positive regulation of membrane potential (GO:0045838)3.96074754
39negative regulation of synaptic transmission, GABAergic (GO:0032229)3.94734481
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.92988291
41cellular potassium ion homeostasis (GO:0030007)3.89229804
42neuron-neuron synaptic transmission (GO:0007270)3.89137931
43potassium ion homeostasis (GO:0055075)3.88100931
44regulation of voltage-gated calcium channel activity (GO:1901385)3.87757026
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82745486
46regulation of synaptic plasticity (GO:0048167)3.82173454
47axon ensheathment in central nervous system (GO:0032291)3.77712487
48central nervous system myelination (GO:0022010)3.77712487
49potassium ion import (GO:0010107)3.74946547
50regulation of postsynaptic membrane potential (GO:0060078)3.70902409
51activation of protein kinase A activity (GO:0034199)3.70884075
52positive regulation of synapse maturation (GO:0090129)3.69177723
53G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.64725737
54gamma-aminobutyric acid transport (GO:0015812)3.62252452
55cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.59054320
56regulation of dendritic spine morphogenesis (GO:0061001)3.59004696
57neuromuscular process controlling balance (GO:0050885)3.54691939
58cytoskeletal anchoring at plasma membrane (GO:0007016)3.50743658
59long-term synaptic potentiation (GO:0060291)3.50405969
60synaptic vesicle endocytosis (GO:0048488)3.50400153
61cell communication by electrical coupling (GO:0010644)3.47290225
62neurotransmitter transport (GO:0006836)3.45536486
63regulation of vesicle fusion (GO:0031338)3.43742862
64regulation of neurotransmitter secretion (GO:0046928)3.41469850
65positive regulation of synaptic transmission, GABAergic (GO:0032230)3.40242646
66neuromuscular synaptic transmission (GO:0007274)3.39912724
67chemosensory behavior (GO:0007635)3.38740224
68cell differentiation in hindbrain (GO:0021533)3.37995472
69cerebellar Purkinje cell differentiation (GO:0021702)3.36009127
70positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.35359410
71neuron recognition (GO:0008038)3.34745409
72positive regulation of neurotransmitter secretion (GO:0001956)3.33880603
73cell migration in hindbrain (GO:0021535)3.33117605
74regulation of ARF protein signal transduction (GO:0032012)3.31791865
75dendritic spine organization (GO:0097061)3.31376648
76innervation (GO:0060384)3.30062952
77acidic amino acid transport (GO:0015800)3.27181331
78neuromuscular process controlling posture (GO:0050884)3.27098167
79regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26828804
80regulation of synaptic transmission, glutamatergic (GO:0051966)3.26168284
81glycine transport (GO:0015816)3.25114803
82positive regulation of neurotransmitter transport (GO:0051590)3.22276682
83regulation of neurotransmitter levels (GO:0001505)3.22147606
84axonal fasciculation (GO:0007413)3.22030510
85transmission of nerve impulse (GO:0019226)3.20923382
86synaptic vesicle transport (GO:0048489)3.19743816
87establishment of synaptic vesicle localization (GO:0097480)3.19743816
88positive regulation of dendrite development (GO:1900006)3.16360216
89behavioral fear response (GO:0001662)3.15900450
90behavioral defense response (GO:0002209)3.15900450
91dendrite morphogenesis (GO:0048813)3.15748161
92synaptic transmission (GO:0007268)3.14695358
93vesicle docking involved in exocytosis (GO:0006904)3.14426869
94positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.14338166
95regulation of neurotransmitter transport (GO:0051588)3.13105943
96membrane depolarization (GO:0051899)3.12181677
97neurotransmitter uptake (GO:0001504)3.11904090
98regulation of dendrite morphogenesis (GO:0048814)3.09299576
99positive regulation of dendritic spine development (GO:0060999)3.09088146
100membrane depolarization during action potential (GO:0086010)3.08361060
101neuronal ion channel clustering (GO:0045161)3.07949844
102auditory behavior (GO:0031223)3.07377405
103positive regulation of dendritic spine morphogenesis (GO:0061003)3.05291230
104regulation of exocytosis (GO:0017157)3.05175426
105regulation of synaptic transmission (GO:0050804)3.05174107
106cerebellar Purkinje cell layer development (GO:0021680)3.04956335
107regulation of calcium ion-dependent exocytosis (GO:0017158)3.03998096
108positive regulation of synaptic transmission (GO:0050806)3.03667397
109vesicle transport along microtubule (GO:0047496)3.03065448
110fear response (GO:0042596)3.02467029
111negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.00822967
112regulation of dendritic spine development (GO:0060998)2.98386714
113postsynaptic membrane organization (GO:0001941)2.97937385
114gamma-aminobutyric acid signaling pathway (GO:0007214)2.97234538
115learning (GO:0007612)2.97133726
116positive regulation of vesicle fusion (GO:0031340)2.96432490
117response to auditory stimulus (GO:0010996)2.95634333
118neuromuscular process (GO:0050905)2.94890961
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94189925
120cellular sodium ion homeostasis (GO:0006883)2.93071519
121membrane hyperpolarization (GO:0060081)2.92400737
122intraspecies interaction between organisms (GO:0051703)2.91779367
123social behavior (GO:0035176)2.91779367
124G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90389555
125detection of calcium ion (GO:0005513)2.90274193

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.29996137
2GBX2_23144817_ChIP-Seq_PC3_Human3.15304300
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08408698
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04608480
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01872681
6* RARB_27405468_Chip-Seq_BRAIN_Mouse3.00622656
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.91461206
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75494096
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75494096
10* DROSHA_22980978_ChIP-Seq_HELA_Human2.75171632
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.73942661
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.62648003
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60388712
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60050583
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44664766
16* REST_18959480_ChIP-ChIP_MESCs_Mouse2.42985480
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42122411
18* EZH2_27304074_Chip-Seq_ESCs_Mouse2.40287988
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33761617
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.33532214
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.31267243
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.28402018
23* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26531116
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.26282843
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15826096
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.11583036
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01386385
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93437285
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.79649014
30AR_21572438_ChIP-Seq_LNCaP_Human1.57356859
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52317177
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46874883
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46573473
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43671419
35* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43403655
36* SMAD4_21799915_ChIP-Seq_A2780_Human1.42792342
37KDM2B_26808549_Chip-Seq_K562_Human1.41154105
38ZNF274_21170338_ChIP-Seq_K562_Hela1.38838875
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36168160
40* RING1B_27294783_Chip-Seq_ESCs_Mouse1.36134395
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35921713
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35816576
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34140085
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32763590
45* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32347917
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32165889
47* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29924832
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.29508006
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27776925
50AR_19668381_ChIP-Seq_PC3_Human1.26531559
51* SOX2_21211035_ChIP-Seq_LN229_Gbm1.24575903
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.20399158
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19364067
54* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18826055
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17968840
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17042323
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16706764
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16566175
59AR_25329375_ChIP-Seq_VCAP_Human1.14895272
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14798504
61SMC4_20622854_ChIP-Seq_HELA_Human1.12228802
62* RING1B_27294783_Chip-Seq_NPCs_Mouse1.12165684
63STAT3_23295773_ChIP-Seq_U87_Human1.11536558
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08220765
65* OCT4_19829295_ChIP-Seq_ESCs_Human1.08157702
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.07007229
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04855807
68* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04104114
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04032261
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03258888
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03125905
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02533717
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02329226
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01593143
75P300_19829295_ChIP-Seq_ESCs_Human1.01139635
76CTCF_27219007_Chip-Seq_Bcells_Human1.00288883
77CREB1_26743006_Chip-Seq_LNCaP_Human0.98974325
78* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97931248
79* TET1_21490601_ChIP-Seq_MESCs_Mouse0.97516290
80DPY_21335234_ChIP-Seq_ESCs_Mouse0.96497650
81SMAD_19615063_ChIP-ChIP_OVARY_Human0.96083742
82SMAD3_21741376_ChIP-Seq_ESCs_Human0.95750044
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95720942
84ARNT_22903824_ChIP-Seq_MCF-7_Human0.95249839
85KDM2B_26808549_Chip-Seq_DND41_Human0.94980645
86TCF4_23295773_ChIP-Seq_U87_Human0.94429984
87KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94331274
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93863562
89* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93138490
90RNF2_27304074_Chip-Seq_NSC_Mouse0.92424237
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92397856
92SMAD4_21741376_ChIP-Seq_HESCs_Human0.91517367
93* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91477572
94SMAD3_21741376_ChIP-Seq_HESCs_Human0.91461243
95TAF15_26573619_Chip-Seq_HEK293_Human0.91403455
96TP53_20018659_ChIP-ChIP_R1E_Mouse0.91369994
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91276236
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91231721
99AHR_22903824_ChIP-Seq_MCF-7_Human0.90965234
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90197564
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89535639
102ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89287386
103* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88992485
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88817539
105* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88634621
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88587277
107P68_20966046_ChIP-Seq_HELA_Human0.88419292
108CBX2_27304074_Chip-Seq_ESCs_Mouse0.87184644
109PIAS1_25552417_ChIP-Seq_VCAP_Human0.86737257
110* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86676425
111RXR_22108803_ChIP-Seq_LS180_Human0.85152364
112KDM2B_26808549_Chip-Seq_JURKAT_Human0.84220810
113KLF4_19829295_ChIP-Seq_ESCs_Human0.83904890
114PRDM14_20953172_ChIP-Seq_ESCs_Human0.83867587
115SMAD4_21741376_ChIP-Seq_ESCs_Human0.82958297
116IGF1R_20145208_ChIP-Seq_DFB_Human0.82753353
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82550689
118CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82167923
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81856842
120LXR_22292898_ChIP-Seq_THP-1_Human0.81728932
121CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81619557
122TP53_16413492_ChIP-PET_HCT116_Human0.81450801
123RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80766356
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79938293
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.75533718
126MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.74484436
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.74417185
128TET1_21451524_ChIP-Seq_MESCs_Mouse0.73745921
129TP53_23651856_ChIP-Seq_MEFs_Mouse0.73208238
130EGR1_19032775_ChIP-ChIP_M12_Human0.71237500
131TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.70957555
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68961739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.55706270
2MP0003880_abnormal_central_pattern4.46116902
3MP0003635_abnormal_synaptic_transmissio4.33832440
4MP0004270_analgesia3.94763448
5MP0009745_abnormal_behavioral_response3.47491528
6MP0002063_abnormal_learning/memory/cond3.45577740
7MP0002822_catalepsy3.33159100
8MP0002064_seizures3.16749229
9MP0002572_abnormal_emotion/affect_behav2.80428544
10MP0009046_muscle_twitch2.67882926
11MP0005423_abnormal_somatic_nervous2.67300159
12MP0001968_abnormal_touch/_nociception2.60124332
13MP0009780_abnormal_chondrocyte_physiolo2.46851909
14MP0002734_abnormal_mechanical_nocicepti2.46775320
15MP0002272_abnormal_nervous_system2.45827448
16MP0001486_abnormal_startle_reflex2.40976744
17MP0001501_abnormal_sleep_pattern2.39862182
18MP0002909_abnormal_adrenal_gland2.17182625
19MP0004858_abnormal_nervous_system2.03887434
20MP0001440_abnormal_grooming_behavior2.03370153
21MP0002735_abnormal_chemical_nociception2.01832679
22MP0003329_amyloid_beta_deposits1.93246431
23MP0008569_lethality_at_weaning1.92716044
24MP0002733_abnormal_thermal_nociception1.91854292
25MP0002736_abnormal_nociception_after1.90782073
26MP0001970_abnormal_pain_threshold1.85817263
27* MP0004811_abnormal_neuron_physiology1.81115956
28MP0003879_abnormal_hair_cell1.71884048
29MP0002067_abnormal_sensory_capabilities1.71743049
30MP0002557_abnormal_social/conspecific_i1.68563643
31MP0000778_abnormal_nervous_system1.68041143
32MP0002184_abnormal_innervation1.65549734
33MP0004924_abnormal_behavior1.64751661
34MP0005386_behavior/neurological_phenoty1.64751661
35MP0005646_abnormal_pituitary_gland1.62160707
36MP0003787_abnormal_imprinting1.56352219
37MP0008961_abnormal_basal_metabolism1.52497537
38* MP0000955_abnormal_spinal_cord1.50807245
39MP0003633_abnormal_nervous_system1.45457764
40MP0002066_abnormal_motor_capabilities/c1.37616593
41MP0003283_abnormal_digestive_organ1.36459411
42MP0004885_abnormal_endolymph1.35652809
43* MP0002882_abnormal_neuron_morphology1.35386126
44MP0001502_abnormal_circadian_rhythm1.30668598
45MP0005645_abnormal_hypothalamus_physiol1.29982803
46MP0003075_altered_response_to1.27240163
47MP0000569_abnormal_digit_pigmentation1.20871209
48MP0003631_nervous_system_phenotype1.16819453
49MP0001984_abnormal_olfaction1.14982531
50MP0001529_abnormal_vocalization1.12719912
51MP0010386_abnormal_urinary_bladder1.12129679
52MP0000013_abnormal_adipose_tissue1.10782229
53MP0003122_maternal_imprinting1.10135315
54MP0002152_abnormal_brain_morphology1.06715431
55MP0002069_abnormal_eating/drinking_beha1.05669910
56MP0006276_abnormal_autonomic_nervous1.04944386
57MP0001905_abnormal_dopamine_level1.02944692
58MP0003172_abnormal_lysosome_physiology1.02426000
59MP0004142_abnormal_muscle_tone0.98631758
60MP0004145_abnormal_muscle_electrophysio0.94131584
61MP0005535_abnormal_body_temperature0.92728779
62MP0001348_abnormal_lacrimal_gland0.92507855
63MP0008872_abnormal_physiological_respon0.91136014
64MP0004510_myositis0.91077807
65MP0001346_abnormal_lacrimal_gland0.88891518
66MP0000604_amyloidosis0.88770971
67MP0002229_neurodegeneration0.88514022
68MP0010234_abnormal_vibrissa_follicle0.86324476
69MP0008874_decreased_physiological_sensi0.85568682
70MP0001485_abnormal_pinna_reflex0.84357135
71MP0000751_myopathy0.83964937
72MP0001177_atelectasis0.83246606
73MP0004085_abnormal_heartbeat0.79624323
74MP0004233_abnormal_muscle_weight0.76206521
75MP0003632_abnormal_nervous_system0.74978929
76MP0003634_abnormal_glial_cell0.74657985
77MP0002653_abnormal_ependyma_morphology0.74651077
78MP0005623_abnormal_meninges_morphology0.74209765
79MP0005167_abnormal_blood-brain_barrier0.73284428
80MP0002090_abnormal_vision0.73149229
81MP0001664_abnormal_digestion0.72324280
82MP0004043_abnormal_pH_regulation0.71464923
83MP0003690_abnormal_glial_cell0.71104955
84MP0005551_abnormal_eye_electrophysiolog0.69624162
85MP0004147_increased_porphyrin_level0.69133789
86MP0000579_abnormal_nail_morphology0.67701333
87MP0002249_abnormal_larynx_morphology0.66683258
88MP0005499_abnormal_olfactory_system0.66434100
89MP0005394_taste/olfaction_phenotype0.66434100
90MP0000631_abnormal_neuroendocrine_gland0.65585215
91MP0002638_abnormal_pupillary_reflex0.64867553
92MP0005187_abnormal_penis_morphology0.63476393
93MP0003183_abnormal_peptide_metabolism0.61843640
94MP0001963_abnormal_hearing_physiology0.61676777
95MP0004130_abnormal_muscle_cell0.61303551
96MP0001188_hyperpigmentation0.61108823
97MP0003861_abnormal_nervous_system0.60502553
98MP0002234_abnormal_pharynx_morphology0.59836881
99MP0010769_abnormal_survival0.59096159
100MP0000920_abnormal_myelination0.58436731
101MP0002693_abnormal_pancreas_physiology0.58276030
102MP0002837_dystrophic_cardiac_calcinosis0.57835800
103MP0001765_abnormal_ion_homeostasis0.57306462
104MP0002752_abnormal_somatic_nervous0.57205505
105MP0001943_abnormal_respiration0.56080349
106MP0010768_mortality/aging0.55904053
107MP0010770_preweaning_lethality0.55823449
108MP0002082_postnatal_lethality0.55823449
109MP0000003_abnormal_adipose_tissue0.55421326
110MP0004484_altered_response_of0.54652855
111MP0003121_genomic_imprinting0.53697711
112MP0001986_abnormal_taste_sensitivity0.53454282
113MP0008877_abnormal_DNA_methylation0.53422133
114MP0003123_paternal_imprinting0.53388255
115MP0000566_synostosis0.52562187
116MP0004742_abnormal_vestibular_system0.52289848
117MP0002876_abnormal_thyroid_physiology0.51655565
118MP0003938_abnormal_ear_development0.51370114
119MP0000026_abnormal_inner_ear0.51320255
120MP0003956_abnormal_body_size0.50088692
121MP0005409_darkened_coat_color0.49594501
122MP0003137_abnormal_impulse_conducting0.48702672

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.36696151
2Focal motor seizures (HP:0011153)7.27749113
3Focal seizures (HP:0007359)5.68524205
4Visual hallucinations (HP:0002367)5.59536932
5Epileptic encephalopathy (HP:0200134)4.57940022
6Atonic seizures (HP:0010819)4.16252422
7Progressive cerebellar ataxia (HP:0002073)4.09020221
8Febrile seizures (HP:0002373)4.05802224
9Action tremor (HP:0002345)3.98483019
10Absence seizures (HP:0002121)3.92486325
11Supranuclear gaze palsy (HP:0000605)3.79849896
12Generalized tonic-clonic seizures (HP:0002069)3.76486544
13Dialeptic seizures (HP:0011146)3.62659584
14Depression (HP:0000716)3.54374837
15Impaired vibration sensation in the lower limbs (HP:0002166)3.46450551
16Ankle clonus (HP:0011448)3.42980033
17Poor eye contact (HP:0000817)3.40915259
18Tetraplegia (HP:0002445)3.33327599
19Papilledema (HP:0001085)3.32459929
20Abnormality of the lower motor neuron (HP:0002366)3.29739222
21Broad-based gait (HP:0002136)3.27221741
22Cerebral hypomyelination (HP:0006808)3.21137493
23Limb dystonia (HP:0002451)3.18286717
24Gaze-evoked nystagmus (HP:0000640)3.15644519
25Postural instability (HP:0002172)3.14812156
26Anxiety (HP:0000739)3.12505510
27Dysmetria (HP:0001310)3.12257604
28Urinary bladder sphincter dysfunction (HP:0002839)3.10510959
29Dysdiadochokinesis (HP:0002075)3.10049529
30Amblyopia (HP:0000646)3.08083573
31Abnormal social behavior (HP:0012433)3.04736180
32Impaired social interactions (HP:0000735)3.04736180
33Truncal ataxia (HP:0002078)2.99224206
34Mutism (HP:0002300)2.93119064
35Impaired smooth pursuit (HP:0007772)2.89902955
36Genetic anticipation (HP:0003743)2.86403468
37Abnormal eating behavior (HP:0100738)2.84766212
38Torticollis (HP:0000473)2.81826362
39Akinesia (HP:0002304)2.78463645
40Hyperventilation (HP:0002883)2.76742048
41Ventricular fibrillation (HP:0001663)2.71046788
42Focal dystonia (HP:0004373)2.67936771
43Epileptiform EEG discharges (HP:0011182)2.67931519
44Urinary urgency (HP:0000012)2.66448950
45Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.64318318
46Sleep apnea (HP:0010535)2.61302457
47Cerebral inclusion bodies (HP:0100314)2.61094322
48Stereotypic behavior (HP:0000733)2.60478892
49Drooling (HP:0002307)2.58064116
50Excessive salivation (HP:0003781)2.58064116
51EEG with generalized epileptiform discharges (HP:0011198)2.56993992
52Spastic gait (HP:0002064)2.55820197
53Hemiparesis (HP:0001269)2.55481442
54Bradykinesia (HP:0002067)2.54054933
55Hemiplegia (HP:0002301)2.53607085
56Annular pancreas (HP:0001734)2.48362571
57Abnormality of ocular smooth pursuit (HP:0000617)2.48204653
58Neurofibrillary tangles (HP:0002185)2.48029084
59Hypsarrhythmia (HP:0002521)2.46831479
60Intention tremor (HP:0002080)2.46563357
61Megalencephaly (HP:0001355)2.45549052
62Insomnia (HP:0100785)2.45143126
63Diminished motivation (HP:0000745)2.41526865
64Peripheral hypomyelination (HP:0007182)2.39497064
65Diplopia (HP:0000651)2.38954641
66Abnormality of binocular vision (HP:0011514)2.38954641
67Spastic tetraparesis (HP:0001285)2.36778915
68Pointed chin (HP:0000307)2.33987121
69Dysmetric saccades (HP:0000641)2.32639996
70Craniofacial dystonia (HP:0012179)2.32135280
71Impaired vibratory sensation (HP:0002495)2.30978828
72Scanning speech (HP:0002168)2.24749238
73Bundle branch block (HP:0011710)2.24588152
74Choreoathetosis (HP:0001266)2.18598986
75Agitation (HP:0000713)2.17488653
76Obstructive sleep apnea (HP:0002870)2.11629363
77Lower limb muscle weakness (HP:0007340)2.10594817
78Fetal akinesia sequence (HP:0001989)2.06844979
79Pheochromocytoma (HP:0002666)2.04776164
80Absent speech (HP:0001344)2.03117751
81Progressive inability to walk (HP:0002505)2.02641818
82Delusions (HP:0000746)1.99547235
83Status epilepticus (HP:0002133)1.99379581
84Abnormal EKG (HP:0003115)1.99103309
85Generalized myoclonic seizures (HP:0002123)1.95218001
86Morphological abnormality of the pyramidal tract (HP:0002062)1.94571776
87Bronchomalacia (HP:0002780)1.94080837
88Polyphagia (HP:0002591)1.93716256
89Insidious onset (HP:0003587)1.93347613
90Termporal pattern (HP:0011008)1.93347613
91CNS hypomyelination (HP:0003429)1.92678797
92Clonus (HP:0002169)1.92331840
93Abnormality of saccadic eye movements (HP:0000570)1.91903099
94Aplasia involving bones of the extremities (HP:0009825)1.91478459
95Aplasia involving bones of the upper limbs (HP:0009823)1.91478459
96Aplasia of the phalanges of the hand (HP:0009802)1.91478459
97Rapidly progressive (HP:0003678)1.91252315
98Apathy (HP:0000741)1.90911455
99Gait ataxia (HP:0002066)1.90759884
100Neuronal loss in central nervous system (HP:0002529)1.90219604
101Hypercortisolism (HP:0001578)1.88885831
102Decreased circulating renin level (HP:0003351)1.88269583
103Incomplete penetrance (HP:0003829)1.88052851
104Rigidity (HP:0002063)1.83854581
105Abnormality of the corticospinal tract (HP:0002492)1.83677937
106Resting tremor (HP:0002322)1.83514537
107Ankyloglossia (HP:0010296)1.82732204
108Psychosis (HP:0000709)1.82288633
109Lower limb asymmetry (HP:0100559)1.81770545
110Spinal canal stenosis (HP:0003416)1.80781486
111Neoplasm of the heart (HP:0100544)1.80423798
112Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79401124
113Degeneration of the lateral corticospinal tracts (HP:0002314)1.79401124
114Amyotrophic lateral sclerosis (HP:0007354)1.79314213
115Increased circulating renin level (HP:0000848)1.78789640
116Turricephaly (HP:0000262)1.77720507
117Intellectual disability, profound (HP:0002187)1.77186665
118Split foot (HP:0001839)1.77147555
119Lower limb amyotrophy (HP:0007210)1.76237158
120Hypoventilation (HP:0002791)1.74451446
121Abnormality of the periventricular white matter (HP:0002518)1.73989675
122Memory impairment (HP:0002354)1.72061022
123Dementia (HP:0000726)1.70947011

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.78394473
2EPHA44.49422083
3MAP3K94.11854927
4DAPK22.85203891
5PRKD32.80664567
6MAP3K42.62273288
7MINK12.58717521
8MARK12.57771850
9CAMKK12.57582813
10KSR22.55491252
11PAK62.40081173
12MAP2K71.93987242
13NTRK11.90992557
14NTRK21.89035174
15KSR11.83499209
16DAPK11.78295180
17RIPK41.73786912
18MAP2K41.62350185
19TNIK1.58978729
20CDK51.56981640
21PRPF4B1.56371507
22MAP3K131.44581795
23STK381.43204499
24SIK21.39779827
25ARAF1.39488654
26MAP3K21.39417365
27GRK51.37857733
28TAOK11.34667388
29MAP3K121.33303398
30FES1.26302755
31PLK21.25491602
32MAPK131.16210919
33PRKCG1.13964514
34UHMK11.13413853
35TYRO31.13072101
36CAMK11.12513892
37CDK191.06170303
38PRKCH1.04319007
39PNCK0.96554852
40CAMKK20.94171955
41PTK2B0.93561836
42RET0.93003317
43STK110.92956374
44RAF10.91331104
45CAMK2A0.87182050
46ALK0.83177264
47SGK4940.82068242
48SGK2230.82068242
49MAP3K110.81946543
50MAP3K10.81164386
51MARK20.80977747
52CDK180.80659972
53CDK150.78958474
54CAMK1D0.78572652
55LATS20.77211101
56CAMK2B0.77086460
57PDK10.76881373
58MAP3K70.76193982
59PINK10.75846382
60BMPR20.75285579
61PHKG20.75281130
62PHKG10.75281130
63CDK140.74718499
64MAPK120.72368280
65SGK20.72142187
66DYRK1A0.70662457
67PAK30.70461819
68SGK30.70039728
69SCYL20.69087011
70PKN10.68093810
71CDK11A0.67544971
72SGK10.67175713
73PDPK10.66770804
74OXSR10.65505488
75CASK0.64764197
76FGFR20.63599788
77BRSK10.62785346
78PASK0.62184486
79CAMK1G0.61787605
80RIPK10.58594129
81NME10.54842583
82LMTK20.54375039
83CDC42BPA0.54306308
84MAP2K10.54061997
85NEK60.53941982
86CAMK40.52662603
87TRIB30.52518553
88RPS6KA30.51296065
89PRKCZ0.49415249
90CSNK1G20.47679761
91FYN0.43677228
92LIMK10.43652390
93DMPK0.43519825
94MAPK100.43458033
95FER0.42806572
96SIK30.42050077
97WNK10.41756479
98INSRR0.41319606
99RPS6KA20.40898433
100DAPK30.40876319
101ERBB20.39627138
102CAMK2D0.36755322
103PRKD20.36429441
104TNK20.36330994
105ROCK20.36235013
106ICK0.35690105
107MAP3K60.35587209
108WNK30.34812250
109TESK10.34669794
110IRAK20.34408737
111MAPK80.34039174
112MAP2K60.33616542
113PRKCE0.33079792
114CAMK2G0.31858895
115PRKCA0.31194766
116BRAF0.31055545
117PRKG20.30174635
118GSK3B0.25666178
119PRKCB0.22202514
120SRC0.22001170

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.29941701
2Synaptic vesicle cycle_Homo sapiens_hsa047213.10982056
3Circadian entrainment_Homo sapiens_hsa047132.78556695
4Long-term potentiation_Homo sapiens_hsa047202.75327972
5Olfactory transduction_Homo sapiens_hsa047402.74269199
6Amphetamine addiction_Homo sapiens_hsa050312.52854487
7Glutamatergic synapse_Homo sapiens_hsa047242.52000961
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.49512422
9GABAergic synapse_Homo sapiens_hsa047272.48072005
10Morphine addiction_Homo sapiens_hsa050322.33275518
11Insulin secretion_Homo sapiens_hsa049112.31880484
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.30803338
13Salivary secretion_Homo sapiens_hsa049702.20076699
14Dopaminergic synapse_Homo sapiens_hsa047282.11073397
15Aldosterone synthesis and secretion_Homo sapiens_hsa049252.02698797
16Cholinergic synapse_Homo sapiens_hsa047251.97539034
17Gastric acid secretion_Homo sapiens_hsa049711.93873320
18Oxytocin signaling pathway_Homo sapiens_hsa049211.69337014
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69297228
20Cocaine addiction_Homo sapiens_hsa050301.66789917
21Calcium signaling pathway_Homo sapiens_hsa040201.60793980
22Vitamin B6 metabolism_Homo sapiens_hsa007501.59568152
23Long-term depression_Homo sapiens_hsa047301.58513191
24Renin secretion_Homo sapiens_hsa049241.58119797
25Taste transduction_Homo sapiens_hsa047421.55671741
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54437630
27GnRH signaling pathway_Homo sapiens_hsa049121.54062980
28Type II diabetes mellitus_Homo sapiens_hsa049301.52247753
29Serotonergic synapse_Homo sapiens_hsa047261.47810410
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46201785
31cAMP signaling pathway_Homo sapiens_hsa040241.33008985
32Pancreatic secretion_Homo sapiens_hsa049721.27754348
33Glioma_Homo sapiens_hsa052141.27616523
34Gap junction_Homo sapiens_hsa045401.27460481
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25888296
36Estrogen signaling pathway_Homo sapiens_hsa049151.23918348
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18507925
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12665656
39Collecting duct acid secretion_Homo sapiens_hsa049661.12036328
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09829891
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09262156
42Nitrogen metabolism_Homo sapiens_hsa009101.08537079
43Melanogenesis_Homo sapiens_hsa049161.03835489
44ErbB signaling pathway_Homo sapiens_hsa040121.02956955
45Dorso-ventral axis formation_Homo sapiens_hsa043200.98515654
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98230559
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.95136551
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91482530
49* Axon guidance_Homo sapiens_hsa043600.90392103
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.87850698
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86627517
52Vibrio cholerae infection_Homo sapiens_hsa051100.86615368
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84753580
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84717129
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84715417
56Thyroid hormone synthesis_Homo sapiens_hsa049180.84687411
57Oocyte meiosis_Homo sapiens_hsa041140.83171795
58VEGF signaling pathway_Homo sapiens_hsa043700.80297920
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.77540282
60Glucagon signaling pathway_Homo sapiens_hsa049220.74901586
61Choline metabolism in cancer_Homo sapiens_hsa052310.74183214
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70202800
63mTOR signaling pathway_Homo sapiens_hsa041500.69252153
64Dilated cardiomyopathy_Homo sapiens_hsa054140.67888841
65MAPK signaling pathway_Homo sapiens_hsa040100.67606654
66Cardiac muscle contraction_Homo sapiens_hsa042600.66811058
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66689604
68Phototransduction_Homo sapiens_hsa047440.66328518
69Type I diabetes mellitus_Homo sapiens_hsa049400.62158199
70Circadian rhythm_Homo sapiens_hsa047100.58592911
71Non-small cell lung cancer_Homo sapiens_hsa052230.57898178
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55417444
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54906030
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54737011
75Bile secretion_Homo sapiens_hsa049760.54733656
76Endometrial cancer_Homo sapiens_hsa052130.53239935
77Rap1 signaling pathway_Homo sapiens_hsa040150.52763239
78Ras signaling pathway_Homo sapiens_hsa040140.52681185
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52416277
80Prion diseases_Homo sapiens_hsa050200.52140458
81Endocytosis_Homo sapiens_hsa041440.51442438
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50205577
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.49805226
84Insulin signaling pathway_Homo sapiens_hsa049100.49797908
85Fatty acid biosynthesis_Homo sapiens_hsa000610.49319163
86Inositol phosphate metabolism_Homo sapiens_hsa005620.48565974
87Alcoholism_Homo sapiens_hsa050340.43853048
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42167592
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41102900
90Renal cell carcinoma_Homo sapiens_hsa052110.39701826
91Wnt signaling pathway_Homo sapiens_hsa043100.37024925
92Chemokine signaling pathway_Homo sapiens_hsa040620.36604929
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36374955
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35502337
95Ovarian steroidogenesis_Homo sapiens_hsa049130.35484759
96Arginine and proline metabolism_Homo sapiens_hsa003300.34628783
97AMPK signaling pathway_Homo sapiens_hsa041520.33870050
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32741833
99Arginine biosynthesis_Homo sapiens_hsa002200.31800450
100Prolactin signaling pathway_Homo sapiens_hsa049170.30895443
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30659203
102Tight junction_Homo sapiens_hsa045300.29375629
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.29292609
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28177712
105African trypanosomiasis_Homo sapiens_hsa051430.28089848
106HIF-1 signaling pathway_Homo sapiens_hsa040660.25917000
107Colorectal cancer_Homo sapiens_hsa052100.25839830
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25824082
109Mineral absorption_Homo sapiens_hsa049780.23926683
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23364456
111Hippo signaling pathway_Homo sapiens_hsa043900.22946944
112Histidine metabolism_Homo sapiens_hsa003400.22869369
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22309971
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.22158622
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.17588000

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