UNC5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.81362499
2axon ensheathment in central nervous system (GO:0032291)7.81362499
3cell migration involved in heart development (GO:0060973)5.01748388
4axon ensheathment (GO:0008366)4.88103656
5ensheathment of neurons (GO:0007272)4.88103656
6vascular endothelial growth factor signaling pathway (GO:0038084)4.83825123
7myelination (GO:0042552)4.78557763
8myelin maintenance (GO:0043217)4.50984708
9endothelium development (GO:0003158)4.42892940
10cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.18637584
11desmosome organization (GO:0002934)4.11441844
12lymph vessel development (GO:0001945)4.04442170
13fatty acid elongation (GO:0030497)3.94825232
14cytoskeletal anchoring at plasma membrane (GO:0007016)3.92092241
15apical protein localization (GO:0045176)3.91122255
16planar cell polarity pathway involved in neural tube closure (GO:0090179)3.84756222
17bone trabecula formation (GO:0060346)3.81382356
18endocardial cushion morphogenesis (GO:0003203)3.80117950
19hemidesmosome assembly (GO:0031581)3.78374031
20peptidyl-tyrosine autophosphorylation (GO:0038083)3.66307805
21coronary vasculature morphogenesis (GO:0060977)3.64922205
22chondrocyte proliferation (GO:0035988)3.64086949
23endocardial cushion development (GO:0003197)3.63576381
24enteric nervous system development (GO:0048484)3.62612719
25asymmetric protein localization (GO:0008105)3.58806009
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.53548738
27negative regulation of protein localization to cell surface (GO:2000009)3.49167159
28virion attachment to host cell (GO:0019062)3.48001219
29adhesion of symbiont to host cell (GO:0044650)3.48001219
30vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.46851795
31Notch signaling involved in heart development (GO:0061314)3.45028443
32mesodermal cell differentiation (GO:0048333)3.38018659
33protein localization to endosome (GO:0036010)3.35324731
34lymphangiogenesis (GO:0001946)3.34642891
35bundle of His cell to Purkinje myocyte communication (GO:0086069)3.30124409
36peripheral nervous system axon ensheathment (GO:0032292)3.29353858
37myelination in peripheral nervous system (GO:0022011)3.29353858
38astrocyte development (GO:0014002)3.27651158
39polarized epithelial cell differentiation (GO:0030859)3.24099128
40creatine metabolic process (GO:0006600)3.23456676
41collagen fibril organization (GO:0030199)3.21235498
42endothelial cell chemotaxis (GO:0035767)3.16816042
43renal filtration (GO:0097205)3.16172081
44mesenchyme morphogenesis (GO:0072132)3.15892209
45neuron projection extension involved in neuron projection guidance (GO:1902284)3.11045326
46axon extension involved in axon guidance (GO:0048846)3.11045326
47cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.10978058
48retina vasculature morphogenesis in camera-type eye (GO:0061299)3.09312319
49cell adhesion mediated by integrin (GO:0033627)3.09162411
50actin filament depolymerization (GO:0030042)3.08204758
51skin morphogenesis (GO:0043589)3.06757308
52endodermal cell differentiation (GO:0035987)3.03908894
53negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.03521778
54ventricular trabecula myocardium morphogenesis (GO:0003222)3.00094041
55craniofacial suture morphogenesis (GO:0097094)2.97596897
56endothelial cell morphogenesis (GO:0001886)2.97496877
57blood vessel endothelial cell migration (GO:0043534)2.97304949
58maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.97277294
59cell-substrate junction assembly (GO:0007044)2.96874969
60long-chain fatty acid biosynthetic process (GO:0042759)2.95982703
61epithelial cell-cell adhesion (GO:0090136)2.95352616
62negative regulation of chondrocyte differentiation (GO:0032331)2.94359298
63gap junction assembly (GO:0016264)2.93616529
64protein retention in ER lumen (GO:0006621)2.92730046
65paraxial mesoderm development (GO:0048339)2.91599276
66lateral sprouting from an epithelium (GO:0060601)2.91171929
67negative regulation of neurotransmitter secretion (GO:0046929)2.90660423
68stress fiber assembly (GO:0043149)2.89671383
69plasma membrane repair (GO:0001778)2.88472127
70extracellular matrix assembly (GO:0085029)2.88170693
71dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.84633138
72regulation of cardioblast differentiation (GO:0051890)2.83444957
73branching involved in salivary gland morphogenesis (GO:0060445)2.83381797
74protein heterotrimerization (GO:0070208)2.81950511
75glomerular filtration (GO:0003094)2.81925609
76Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.80334184
77wound healing, spreading of cells (GO:0044319)2.79078817
78blood vessel maturation (GO:0001955)2.77947759
79semaphorin-plexin signaling pathway (GO:0071526)2.76962400
80regulation of axon extension involved in axon guidance (GO:0048841)2.76887433
81wound healing, spreading of epidermal cells (GO:0035313)2.76793350
82convergent extension (GO:0060026)2.76699005
83hippo signaling (GO:0035329)2.76342776
84regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.75173509
85ganglion development (GO:0061548)2.73294658
86atrioventricular valve morphogenesis (GO:0003181)2.73123221
87positive regulation of osteoblast proliferation (GO:0033690)2.71896579
88cranial suture morphogenesis (GO:0060363)2.71692641
89membrane tubulation (GO:0097320)2.71667824
90negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.70805685
91glomerular basement membrane development (GO:0032836)2.69009714
92oligodendrocyte differentiation (GO:0048709)2.68735489
93cell surface receptor signaling pathway involved in heart development (GO:0061311)2.67940828
94cell-cell junction assembly (GO:0007043)2.67618858
95negative regulation of catenin import into nucleus (GO:0035414)2.66820781
96regulation of establishment of planar polarity (GO:0090175)2.65878413
97artery morphogenesis (GO:0048844)2.65637190
98cortical actin cytoskeleton organization (GO:0030866)2.64980165
99adhesion of symbiont to host (GO:0044406)2.64092676
100aorta morphogenesis (GO:0035909)2.62505532
101focal adhesion assembly (GO:0048041)2.61446098
102cell-substrate adherens junction assembly (GO:0007045)2.61446098
103heart valve morphogenesis (GO:0003179)2.61241242
104multicellular organismal macromolecule metabolic process (GO:0044259)2.60443140
105adherens junction assembly (GO:0034333)2.59886092
106establishment of apical/basal cell polarity (GO:0035089)2.58318826
107surfactant homeostasis (GO:0043129)2.58050933
108heart valve formation (GO:0003188)2.57888469
109sodium ion export (GO:0071436)2.57586831
110establishment of tissue polarity (GO:0007164)2.56484811
111establishment of planar polarity (GO:0001736)2.56484811
112cardiac chamber formation (GO:0003207)2.55626821
113peripheral nervous system neuron development (GO:0048935)2.55602822
114establishment of mitochondrion localization (GO:0051654)2.54069680
115cholesterol biosynthetic process (GO:0006695)2.53666493
116cell communication by electrical coupling (GO:0010644)2.53279519
117negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.53271303
118cell migration in hindbrain (GO:0021535)2.53070000
119extracellular matrix disassembly (GO:0022617)2.53006702
120patterning of blood vessels (GO:0001569)2.52391112
121endothelial cell differentiation (GO:0045446)2.52072470
122lens fiber cell development (GO:0070307)2.51596688
123negative regulation of neurotransmitter transport (GO:0051589)2.49913942
124cardiac ventricle formation (GO:0003211)2.49351122
125synaptic vesicle docking involved in exocytosis (GO:0016081)2.49220787
126negative regulation of blood vessel endothelial cell migration (GO:0043537)2.49187956
127embryonic heart tube development (GO:0035050)2.48019100
128establishment or maintenance of apical/basal cell polarity (GO:0035088)2.47704177
129establishment or maintenance of bipolar cell polarity (GO:0061245)2.47704177
130negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.47597807
131multicellular organismal catabolic process (GO:0044243)2.47376681
132neural tube development (GO:0021915)2.46614290
133apoptotic process involved in morphogenesis (GO:0060561)2.46172473
134regulation of secondary heart field cardioblast proliferation (GO:0003266)2.45694083
135regulation of cardioblast proliferation (GO:0003264)2.45694083
136positive regulation of Rho protein signal transduction (GO:0035025)2.45403175
137cardiac epithelial to mesenchymal transition (GO:0060317)2.45040730
138chondrocyte development (GO:0002063)2.44888460
139venous blood vessel morphogenesis (GO:0048845)2.43721216
140non-canonical Wnt signaling pathway (GO:0035567)2.43170759
141outflow tract septum morphogenesis (GO:0003148)2.42837776
142import into cell (GO:0098657)2.42712232
143trabecula formation (GO:0060343)2.42540013
144regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.42310073
145negative regulation of axon extension involved in axon guidance (GO:0048843)2.41800243
146neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.41787806
147response to lipoprotein particle (GO:0055094)2.41706535
148multicellular organismal metabolic process (GO:0044236)2.41501607
149cell junction assembly (GO:0034329)2.40553945
150limb bud formation (GO:0060174)2.39654888
151collagen metabolic process (GO:0032963)2.39534569
152membrane raft organization (GO:0031579)2.38872733
153blood vessel morphogenesis (GO:0048514)2.37534502
154cortical cytoskeleton organization (GO:0030865)2.37149588
155collagen catabolic process (GO:0030574)2.37028365
156negative regulation of adherens junction organization (GO:1903392)2.36777688
157negative regulation of focal adhesion assembly (GO:0051895)2.36777688
158negative regulation of cell junction assembly (GO:1901889)2.36777688
159cochlea morphogenesis (GO:0090103)2.35743210
160sequestering of extracellular ligand from receptor (GO:0035581)2.34925014
161regulation of axon guidance (GO:1902667)2.33576034
162positive regulation of oligodendrocyte differentiation (GO:0048714)2.33269661
163basement membrane organization (GO:0071711)2.32650338
164positive regulation of actin filament depolymerization (GO:0030836)2.32635471
165establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.32489147
166camera-type eye morphogenesis (GO:0048593)2.32254869
167lung-associated mesenchyme development (GO:0060484)2.32227812
168peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.31929936
169neuromuscular junction development (GO:0007528)2.30811018
170anterior/posterior axis specification, embryo (GO:0008595)2.30485741
171substrate adhesion-dependent cell spreading (GO:0034446)2.29622268
172axis elongation (GO:0003401)2.28878562
173cell migration involved in sprouting angiogenesis (GO:0002042)2.28794663
174regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.28569172
175protein localization to cell surface (GO:0034394)2.28539134
176mesenchymal cell proliferation (GO:0010463)2.28480151
177negative regulation of smooth muscle cell migration (GO:0014912)2.28097189

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.46469868
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.35698671
3* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.54870937
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52496700
5* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.48360835
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.41686520
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.40565538
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.29709256
9WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.20189034
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.17858567
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.12202092
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.10024052
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04906146
14* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04898107
15* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04898107
16LXR_22292898_ChIP-Seq_THP-1_Human2.01037419
17* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00979621
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.85972947
19* EED_16625203_ChIP-ChIP_MESCs_Mouse1.83439769
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82482668
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81964489
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.80897329
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77134262
24ZNF263_19887448_ChIP-Seq_K562_Human1.75028970
25UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.65903775
26* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.62607576
27* EZH2_27304074_Chip-Seq_ESCs_Mouse1.62003177
28* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61092161
29* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60997444
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60095406
31* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59094135
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58877822
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57052831
34* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56736837
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55746468
36CLOCK_20551151_ChIP-Seq_293T_Human1.55236105
37* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55228527
38* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55023629
39* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.54379505
40* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53769733
41* EZH2_27294783_Chip-Seq_ESCs_Mouse1.49337114
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.48900264
43* RNF2_27304074_Chip-Seq_ESCs_Mouse1.47872409
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45986228
45CJUN_26792858_Chip-Seq_BT549_Human1.44794003
46P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44757854
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43287397
48TET1_21490601_ChIP-Seq_MESCs_Mouse1.41460133
49DROSHA_22980978_ChIP-Seq_HELA_Human1.40936708
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39601904
51* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39228167
52* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39228167
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38380141
54* ISL1_27105846_Chip-Seq_CPCs_Mouse1.38104771
55CTCF_27219007_Chip-Seq_Bcells_Human1.37968044
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36119575
57* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35144539
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.34958037
59* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34439992
60* RING1B_27294783_Chip-Seq_NPCs_Mouse1.33481010
61TP53_16413492_ChIP-PET_HCT116_Human1.33089805
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33071546
63* KDM2B_26808549_Chip-Seq_K562_Human1.31758114
64* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30639155
65* TP53_20018659_ChIP-ChIP_R1E_Mouse1.30423222
66HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30221251
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28810300
68* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27839928
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27504555
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26297528
71* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24588897
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24532721
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.22573133
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21601908
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20560493
76* ELK3_25401928_ChIP-Seq_HUVEC_Human1.20006443
77* TP53_22127205_ChIP-Seq_IMR90_Human1.19747275
78* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17286747
79SOX2_20726797_ChIP-Seq_SW620_Human1.16765793
80* KLF5_25053715_ChIP-Seq_YYC3_Human1.16739025
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16713995
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16713398
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.16265440
84TBX20_22328084_ChIP-Seq_HEART_Mouse1.16265440
85* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16243524
86* RACK7_27058665_Chip-Seq_MCF-7_Human1.15520926
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14194639
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14026151
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14026151
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14026151
91* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12803405
92* TP53_23651856_ChIP-Seq_MEFs_Mouse1.12700586
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12669758
94* RING1B_27294783_Chip-Seq_ESCs_Mouse1.11779941
95* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11710623
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11376082
97* KDM2B_26808549_Chip-Seq_DND41_Human1.11288980
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10392631
99AHR_22903824_ChIP-Seq_MCF-7_Human1.08976423
100* UBF1/2_26484160_Chip-Seq_HMECs_Human1.08811263
101* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08576386
102* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06903573
103DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05715130
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05426340
105P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05334844
106SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05184932
107SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05184932
108NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04797152
109ESR1_21235772_ChIP-Seq_MCF-7_Human1.03615157
110* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03558941
111JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02769301
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02508848
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02348729
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01688132
115SMC4_20622854_ChIP-Seq_HELA_Human1.00663593
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00626606
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00611689
118* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00347681
119SA1_27219007_Chip-Seq_ERYTHROID_Human0.99190981
120* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98995270
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97423129
122CREB1_26743006_Chip-Seq_LNCaP_Human0.97231416
123JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97022711
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96880341
125TP53_18474530_ChIP-ChIP_U2OS_Human0.96545777
126ARNT_22903824_ChIP-Seq_MCF-7_Human0.96055279
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95748808
128EOMES_21245162_ChIP-Seq_HESCs_Human0.95579449
129KDM2B_26808549_Chip-Seq_JURKAT_Human0.95112613
130* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94313693

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.88402438
2MP0005623_abnormal_meninges_morphology3.59923949
3MP0004272_abnormal_basement_membrane3.14923885
4MP0003950_abnormal_plasma_membrane2.88179659
5MP0005275_abnormal_skin_tensile2.82674304
6MP0005503_abnormal_tendon_morphology2.61640090
7MP0001879_abnormal_lymphatic_vessel2.58121854
8MP0003705_abnormal_hypodermis_morpholog2.49584199
9MP0000920_abnormal_myelination2.49545604
10MP0005409_darkened_coat_color2.40584745
11MP0000537_abnormal_urethra_morphology2.35964650
12MP0010030_abnormal_orbit_morphology2.27792799
13MP0003279_aneurysm2.22518235
14MP0003385_abnormal_body_wall2.10950815
15MP0001299_abnormal_eye_distance/2.03267302
16MP0003941_abnormal_skin_development1.90358505
17MP0003566_abnormal_cell_adhesion1.79507370
18MP0009250_abnormal_appendicular_skeleto1.77489270
19MP0005257_abnormal_intraocular_pressure1.76496867
20MP0001958_emphysema1.72661089
21MP0009384_cardiac_valve_regurgitation1.71584339
22MP0003937_abnormal_limbs/digits/tail_de1.69050313
23MP0000733_abnormal_muscle_development1.67136763
24MP0000462_abnormal_digestive_system1.64972095
25MP0001348_abnormal_lacrimal_gland1.62868124
26MP0010678_abnormal_skin_adnexa1.55995277
27MP0004134_abnormal_chest_morphology1.54062723
28MP0005508_abnormal_skeleton_morphology1.51747991
29MP0004858_abnormal_nervous_system1.51028645
30MP0000762_abnormal_tongue_morphology1.49272250
31MP0002295_abnormal_pulmonary_circulatio1.49263382
32MP0004084_abnormal_cardiac_muscle1.48260514
33MP0003091_abnormal_cell_migration1.47597594
34MP0003283_abnormal_digestive_organ1.45365785
35MP0000751_myopathy1.44166929
36MP0005171_absent_coat_pigmentation1.38264704
37MP0000534_abnormal_ureter_morphology1.36463036
38MP0010368_abnormal_lymphatic_system1.32398363
39MP0003755_abnormal_palate_morphology1.31794706
40MP0009053_abnormal_anal_canal1.27507582
41MP0000747_muscle_weakness1.27383476
42MP0000428_abnormal_craniofacial_morphol1.24564192
43MP0000003_abnormal_adipose_tissue1.24337411
44MP0002249_abnormal_larynx_morphology1.23955585
45MP0000383_abnormal_hair_follicle1.23835133
46MP0002896_abnormal_bone_mineralization1.22741351
47MP0000013_abnormal_adipose_tissue1.22073382
48MP0003329_amyloid_beta_deposits1.22042272
49MP0003122_maternal_imprinting1.21365772
50MP0006138_congestive_heart_failure1.20942814
51MP0004885_abnormal_endolymph1.20585962
52MP0002822_catalepsy1.17677103
53MP0003634_abnormal_glial_cell1.17651061
54MP0002108_abnormal_muscle_morphology1.16544666
55MP0000467_abnormal_esophagus_morphology1.15344039
56MP0005023_abnormal_wound_healing1.14676516
57MP0002932_abnormal_joint_morphology1.14149936
58MP0000579_abnormal_nail_morphology1.11299859
59MP0004185_abnormal_adipocyte_glucose1.09638919
60MP0003942_abnormal_urinary_system1.09282526
61MP0003935_abnormal_craniofacial_develop1.08840024
62MP0000749_muscle_degeneration1.08720307
63MP0002060_abnormal_skin_morphology1.08645102
64MP0004087_abnormal_muscle_fiber1.08106398
65MP0006054_spinal_hemorrhage1.07463795
66MP0002254_reproductive_system_inflammat1.07244776
67MP0004233_abnormal_muscle_weight1.06937373
68MP0001243_abnormal_dermal_layer1.06642343
69MP0005501_abnormal_skin_physiology1.04602294
70MP0005595_abnormal_vascular_smooth1.04483447
71MP0010352_gastrointestinal_tract_polyps1.04209374
72MP0004036_abnormal_muscle_relaxation1.02422453
73MP0004145_abnormal_muscle_electrophysio1.01593946
74MP0001346_abnormal_lacrimal_gland1.00219167
75MP0002233_abnormal_nose_morphology0.99746291
76MP0000647_abnormal_sebaceous_gland0.99587032
77MP0005330_cardiomyopathy0.99061162
78MP0000778_abnormal_nervous_system0.98919357
79MP0000432_abnormal_head_morphology0.98502959
80MP0004859_abnormal_synaptic_plasticity0.97896099
81MP0009780_abnormal_chondrocyte_physiolo0.97412283
82MP0003115_abnormal_respiratory_system0.97173127
83MP0004264_abnormal_extraembryonic_tissu0.97126544
84MP0000767_abnormal_smooth_muscle0.96852354
85MP0002111_abnormal_tail_morphology0.96448843
86MP0001849_ear_inflammation0.96405972
87MP0002098_abnormal_vibrissa_morphology0.95334625
88MP0004270_analgesia0.95276901
89MP0002751_abnormal_autonomic_nervous0.95260652
90MP0004133_heterotaxia0.94692512
91MP0000163_abnormal_cartilage_morphology0.93379423
92MP0003453_abnormal_keratinocyte_physiol0.91818419
93MP0000750_abnormal_muscle_regeneration0.91545237
94MP0000516_abnormal_urinary_system0.91378525
95MP0005367_renal/urinary_system_phenotyp0.91378525
96MP0000566_synostosis0.90763321
97MP0004742_abnormal_vestibular_system0.90612179
98MP0003632_abnormal_nervous_system0.89738622
99MP0002116_abnormal_craniofacial_bone0.89388358
100MP0002697_abnormal_eye_size0.89348719
101MP0004782_abnormal_surfactant_physiolog0.89208625
102MP0000538_abnormal_urinary_bladder0.88545332
103MP0000049_abnormal_middle_ear0.88255644
104MP0001485_abnormal_pinna_reflex0.86601355
105* MP0002925_abnormal_cardiovascular_devel0.86131517
106MP0001340_abnormal_eyelid_morphology0.85786282
107MP0001270_distended_abdomen0.85063937
108MP0010630_abnormal_cardiac_muscle0.84709131
109MP0002128_abnormal_blood_circulation0.84565532
110* MP0001614_abnormal_blood_vessel0.83599544
111MP0002234_abnormal_pharynx_morphology0.83387850
112MP0003690_abnormal_glial_cell0.82523973
113MP0010234_abnormal_vibrissa_follicle0.82206902
114MP0001542_abnormal_bone_strength0.82159731
115MP0000759_abnormal_skeletal_muscle0.82124548
116MP0003137_abnormal_impulse_conducting0.81595611
117MP0002115_abnormal_skeleton_extremities0.79867919
118MP0001915_intracranial_hemorrhage0.79365359
119MP0003828_pulmonary_edema0.79124811
120MP0002796_impaired_skin_barrier0.77389815
121MP0002282_abnormal_trachea_morphology0.76770562
122MP0002114_abnormal_axial_skeleton0.75632038
123MP0005165_increased_susceptibility_to0.74247110
124MP0010771_integument_phenotype0.74169388
125MP0000377_abnormal_hair_follicle0.73810018
126MP0002972_abnormal_cardiac_muscle0.73546251
127MP0003119_abnormal_digestive_system0.73452057
128MP0002084_abnormal_developmental_patter0.71708584
129MP0000678_abnormal_parathyroid_gland0.69454743
130MP0005187_abnormal_penis_morphology0.69452485
131MP0002127_abnormal_cardiovascular_syste0.69415201
132MP0003567_abnormal_fetal_cardiomyocyte0.67714845
133MP0005076_abnormal_cell_differentiation0.66362753
134MP0005197_abnormal_uvea_morphology0.64104825

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.05862245
2Protrusio acetabuli (HP:0003179)4.93124916
3Shallow orbits (HP:0000586)4.19724935
4Degeneration of the lateral corticospinal tracts (HP:0002314)3.42430927
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.42430927
6Atrophic scars (HP:0001075)3.39542782
7Broad metatarsal (HP:0001783)3.33642148
8Muscle fiber splitting (HP:0003555)3.19112283
9Aortic dissection (HP:0002647)3.15636227
10Abnormality of dentin (HP:0010299)3.03541854
11Coronal craniosynostosis (HP:0004440)3.02131341
12Bowel diverticulosis (HP:0005222)2.99425694
13Fragile skin (HP:0001030)2.90023510
14Follicular hyperkeratosis (HP:0007502)2.88569705
15Infantile muscular hypotonia (HP:0008947)2.83622144
16Peritonitis (HP:0002586)2.83472688
17Hyporeflexia of lower limbs (HP:0002600)2.77125687
18Bladder diverticulum (HP:0000015)2.71520983
19Wormian bones (HP:0002645)2.69403703
20Ulnar bowing (HP:0003031)2.68545193
21Soft skin (HP:0000977)2.68345483
22Neurofibrillary tangles (HP:0002185)2.67596724
23Hyperacusis (HP:0010780)2.67442476
24Buphthalmos (HP:0000557)2.66703716
25Nonimmune hydrops fetalis (HP:0001790)2.63333721
26Scapular winging (HP:0003691)2.60040305
27Hypoventilation (HP:0002791)2.57617264
28Abnormality of the corticospinal tract (HP:0002492)2.46711377
29Stridor (HP:0010307)2.46495064
30Aplasia involving bones of the upper limbs (HP:0009823)2.43291072
31Aplasia of the phalanges of the hand (HP:0009802)2.43291072
32Aplasia involving bones of the extremities (HP:0009825)2.43291072
33Cerebral inclusion bodies (HP:0100314)2.43054752
34Lymphangioma (HP:0100764)2.39815871
35Cerebral aneurysm (HP:0004944)2.38206793
36Termporal pattern (HP:0011008)2.38048289
37Insidious onset (HP:0003587)2.38048289
38Round ear (HP:0100830)2.31713885
39Sensory axonal neuropathy (HP:0003390)2.30373119
40Ankle contracture (HP:0006466)2.30191388
41Mildly elevated creatine phosphokinase (HP:0008180)2.28982384
42Spinal rigidity (HP:0003306)2.25280827
43Joint laxity (HP:0001388)2.24685309
44Abnormal vertebral ossification (HP:0100569)2.24566934
45Hypoplasia of the iris (HP:0007676)2.24262592
46Absent eyelashes (HP:0000561)2.22783879
47Right ventricular cardiomyopathy (HP:0011663)2.21561714
48Obstructive sleep apnea (HP:0002870)2.21027762
49Fused cervical vertebrae (HP:0002949)2.18163028
50Blue sclerae (HP:0000592)2.18139546
51Bell-shaped thorax (HP:0001591)2.15724069
52Short hallux (HP:0010109)2.14946747
53Alacrima (HP:0000522)2.14667280
54Abnormality of the 2nd finger (HP:0004100)2.13472810
55Distal upper limb amyotrophy (HP:0007149)2.13351341
56Upper limb amyotrophy (HP:0009129)2.13351341
57Hyperextensible skin (HP:0000974)2.11777359
58Natal tooth (HP:0000695)2.10713222
59Abnormality of nail color (HP:0100643)2.09881285
60Advanced eruption of teeth (HP:0006288)2.07704029
61Increased variability in muscle fiber diameter (HP:0003557)2.06852205
62Onion bulb formation (HP:0003383)2.06788567
63Abnormality of the middle phalanges of the toes (HP:0010183)2.03921956
64Neonatal short-limb short stature (HP:0008921)2.03007071
65Genu recurvatum (HP:0002816)2.01840750
66Hypercalcemia (HP:0003072)2.01126268
67Bronchomalacia (HP:0002780)2.00316961
68Congenital glaucoma (HP:0001087)1.99026021
69Insomnia (HP:0100785)1.98533084
70Biconcave vertebral bodies (HP:0004586)1.96872687
71Vertebral compression fractures (HP:0002953)1.96354595
72Difficulty running (HP:0009046)1.96335338
73Hypoplastic ischia (HP:0003175)1.95516806
74Abnormality of the distal phalanx of the thumb (HP:0009617)1.95231865
75Pterygium (HP:0001059)1.94044883
76Bowed forearm bones (HP:0003956)1.93530615
77Bowing of the arm (HP:0006488)1.93530615
78Mitral valve prolapse (HP:0001634)1.92223815
79Alopecia of scalp (HP:0002293)1.91403707
80Turricephaly (HP:0000262)1.90572670
81Aplasia/Hypoplasia of the hallux (HP:0008362)1.90499182
82Tibial bowing (HP:0002982)1.90105749
83Wide anterior fontanel (HP:0000260)1.89718891
84Ectopia lentis (HP:0001083)1.89633629
85Hypoplastic pelvis (HP:0008839)1.88737114
86Type 1 muscle fiber predominance (HP:0003803)1.87249612
87Limited hip movement (HP:0008800)1.86932228
88Mitral regurgitation (HP:0001653)1.86571384
89Abnormal umbilical cord blood vessels (HP:0011403)1.86017746
90Single umbilical artery (HP:0001195)1.86017746
91Abnormality of the fetal cardiovascular system (HP:0010948)1.86017746
92Femoral bowing (HP:0002980)1.85836864
93Esophageal atresia (HP:0002032)1.85787369
94Renovascular hypertension (HP:0100817)1.85094682
95Abnormality of the phalanges of the 2nd finger (HP:0009541)1.84889480
96Dilatation of the ascending aorta (HP:0005111)1.83695935
97Skull defect (HP:0001362)1.83416747
98Tracheal stenosis (HP:0002777)1.82784759
99Protruding ear (HP:0000411)1.82750810
100Aneurysm (HP:0002617)1.82633654
101Renal duplication (HP:0000075)1.82411094
102Aortic aneurysm (HP:0004942)1.81694031
103Broad ribs (HP:0000885)1.80656878
104Increased connective tissue (HP:0009025)1.80556039
105Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79759747
106Vertebral clefting (HP:0008428)1.79695907
107Foot dorsiflexor weakness (HP:0009027)1.79497313
108Synostosis involving the elbow (HP:0003938)1.79177755
109Humeroradial synostosis (HP:0003041)1.79177755
110Vertebral arch anomaly (HP:0008438)1.79158844
111Deviation of the hallux (HP:0010051)1.78960780
112Premature skin wrinkling (HP:0100678)1.78759696
113Arnold-Chiari malformation (HP:0002308)1.78395335
114Overriding aorta (HP:0002623)1.77257566
115Asymmetry of the thorax (HP:0001555)1.77055776
116Wrist flexion contracture (HP:0001239)1.76606854
117Selective tooth agenesis (HP:0001592)1.76294167
118Partial duplication of the phalanx of hand (HP:0009999)1.75281048
119Disproportionate tall stature (HP:0001519)1.75013065
120Vascular tortuosity (HP:0004948)1.74686984
121Hip contracture (HP:0003273)1.74621755
122Venous insufficiency (HP:0005293)1.74488457
123Peripheral hypomyelination (HP:0007182)1.73486964
124Abnormality of the foot musculature (HP:0001436)1.73032522
125Preaxial foot polydactyly (HP:0001841)1.71618257
126Abnormality of the umbilical cord (HP:0010881)1.70803758
127Camptodactyly of toe (HP:0001836)1.70340631
128Hallux valgus (HP:0001822)1.70153075
129Elfin facies (HP:0004428)1.69782952
130Hypotrichosis (HP:0001006)1.69431007
131Overgrowth (HP:0001548)1.68962494
132Mild short stature (HP:0003502)1.67886266
133Pili torti (HP:0003777)1.66820312
134Cervical subluxation (HP:0003308)1.66336039
135Arterial tortuosity (HP:0005116)1.66102574
136Abnormality of skeletal muscle fiber size (HP:0012084)1.65740827
137Flat cornea (HP:0007720)1.65391097
138Trismus (HP:0000211)1.64960871
139Inguinal hernia (HP:0000023)1.62968151
140Venous abnormality (HP:0002624)1.61468993
141Abnormality of the phalanges of the hallux (HP:0010057)1.59894185
142Spinal cord compression (HP:0002176)1.57580360
143Calcaneovalgus deformity (HP:0001848)1.56541917
144Absent hand (HP:0004050)1.55650128
145Slender build (HP:0001533)1.55630941
146Thin ribs (HP:0000883)1.55161216
147Plantar hyperkeratosis (HP:0007556)1.53382578
148Esophageal varix (HP:0002040)1.52819270
149Fragile nails (HP:0001808)1.50788383
150Woolly hair (HP:0002224)1.50562750
151Hand muscle atrophy (HP:0009130)1.50393849

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.48639433
2MET3.11837292
3TTN3.03617560
4DDR22.85418910
5EEF2K2.80126180
6EPHB12.70190755
7OXSR12.65924517
8LIMK12.46008240
9EPHA22.03040428
10TESK22.02300825
11FGFR21.93748704
12BCR1.91343088
13LATS11.85802368
14WNK11.82767123
15DMPK1.81653136
16WNK41.80072530
17PIK3CA1.75779043
18PAK31.75708877
19ROCK21.74086373
20ICK1.73943501
21SMG11.72974285
22PDGFRA1.72924345
23PAK21.71655660
24MAPKAPK51.71253439
25NTRK11.64156750
26PTK21.63725569
27CDK121.59906825
28LATS21.57485275
29EPHB21.53258050
30PKN11.51042966
31BMX1.47750285
32TRPM71.45119635
33PAK61.42330496
34TRIB31.30471709
35CSNK1A1L1.28478677
36MAP3K101.25764505
37RPS6KA21.24783858
38CAMK2D1.23850731
39TYRO31.20781088
40PNCK1.17601623
41LMTK21.15570198
42RIPK11.11275874
43CAMK2B1.10182455
44UHMK11.06969607
45PTK2B1.06002057
46KSR21.04996060
47PRKD11.04376611
48CSNK1G31.02771763
49FGFR41.01424784
50FER1.00809298
51CDK190.98547871
52CAMK1D0.98222641
53PDGFRB0.97542389
54TESK10.96943667
55MAP2K20.96652709
56FGFR10.96501983
57PTK60.95745282
58MAP3K60.95303617
59PBK0.94232698
60PAK40.94039705
61ROCK10.91686077
62MAP3K90.91321557
63CDK140.91253616
64ILK0.90276335
65FLT30.90215619
66CLK10.86546540
67MAP3K20.83636645
68CDK150.83291546
69NEK60.81448145
70MTOR0.81100695
71CSNK1G10.80514426
72LRRK20.80105329
73FGR0.77651547
74MST1R0.77626890
75PAK10.77085652
76MOS0.76989596
77TIE10.75312422
78CDK180.74688891
79CDK11A0.74468481
80TGFBR10.74230704
81MST40.74226953
82DAPK30.73960208
83MARK20.73862654
84STK380.73610051
85ERBB40.72438427
86PRPF4B0.71991946
87CAMK2G0.70474607
88TGFBR20.68857409
89STK30.67795649
90MYLK0.66850030
91CSNK1G20.66709435
92CAMK1G0.65787658
93CDC42BPA0.65739313
94PRKD30.63451237
95NTRK30.63153662
96ERN10.62508189
97PKN20.59213287
98PRKG20.59110855
99SIK10.59087748
100MAP2K10.58875277
101ABL20.58688918
102MAPKAPK30.56540529
103INSR0.55982727
104MAP3K80.55747551
105ARAF0.54398539
106MAPK70.53630019
107MAP3K70.51540737
108FYN0.51385258
109KDR0.51232719
110PRKCH0.50163634
111CAMK2A0.48149901
112ALK0.46926417
113RPS6KL10.46728720
114RPS6KC10.46728720
115SRC0.46355962
116RET0.46278608
117GSK3A0.45959975
118CSNK1D0.45353040
119AKT30.44660019
120PRKCE0.43753926
121STK100.43644497
122MAPK100.40839048
123NTRK20.40711295
124PRKD20.40571790
125SGK2230.39975913
126SGK4940.39975913
127PHKG20.38961302
128STK38L0.38143697
129CAMK10.34602548
130MARK10.34390633
131CDK50.33690077
132NEK90.29973685
133RPS6KA60.29026812
134MAPK120.28093398
135STK240.25619775
136ERBB20.25244967
137DYRK1B0.25236494
138MAPK90.24704616
139SGK30.23803985
140MAPK10.22619779
141MAPK80.22279246

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.61579100
2ECM-receptor interaction_Homo sapiens_hsa045123.36383575
3Steroid biosynthesis_Homo sapiens_hsa001002.60575322
4Tight junction_Homo sapiens_hsa045302.43581428
5Focal adhesion_Homo sapiens_hsa045102.40048449
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.33590126
7Hippo signaling pathway_Homo sapiens_hsa043902.21721222
8* Axon guidance_Homo sapiens_hsa043602.18970586
9Dilated cardiomyopathy_Homo sapiens_hsa054142.15355245
10Fatty acid elongation_Homo sapiens_hsa000622.09809549
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.00475726
12Basal cell carcinoma_Homo sapiens_hsa052171.97980359
13Hedgehog signaling pathway_Homo sapiens_hsa043401.97945876
14Proteoglycans in cancer_Homo sapiens_hsa052051.87576169
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.78156297
16Renal cell carcinoma_Homo sapiens_hsa052111.71363398
17Protein digestion and absorption_Homo sapiens_hsa049741.66919742
18Prion diseases_Homo sapiens_hsa050201.64168144
19Ether lipid metabolism_Homo sapiens_hsa005651.60222610
20Adherens junction_Homo sapiens_hsa045201.56956388
21Bladder cancer_Homo sapiens_hsa052191.54448664
22Regulation of actin cytoskeleton_Homo sapiens_hsa048101.53105905
23TGF-beta signaling pathway_Homo sapiens_hsa043501.52728580
24Amoebiasis_Homo sapiens_hsa051461.41218122
25Thyroid cancer_Homo sapiens_hsa052161.39922603
26Thyroid hormone signaling pathway_Homo sapiens_hsa049191.38995246
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.37590975
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.33567575
29MicroRNAs in cancer_Homo sapiens_hsa052061.26160861
30PI3K-Akt signaling pathway_Homo sapiens_hsa041511.25696730
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25107354
32Gap junction_Homo sapiens_hsa045401.20605052
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18488233
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18337878
35Sulfur metabolism_Homo sapiens_hsa009201.18008368
36Melanogenesis_Homo sapiens_hsa049161.15747331
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15696503
38Rap1 signaling pathway_Homo sapiens_hsa040151.15528192
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13490261
40Mineral absorption_Homo sapiens_hsa049781.12001340
41Insulin secretion_Homo sapiens_hsa049111.11955871
42Wnt signaling pathway_Homo sapiens_hsa043101.11772667
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.08616281
44Small cell lung cancer_Homo sapiens_hsa052221.06232735
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05188017
46Long-term depression_Homo sapiens_hsa047301.04725223
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03387491
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.00506706
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00082085
50Nitrogen metabolism_Homo sapiens_hsa009100.99503321
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99108632
52Other glycan degradation_Homo sapiens_hsa005110.98669607
53Dorso-ventral axis formation_Homo sapiens_hsa043200.97299759
54Endocytosis_Homo sapiens_hsa041440.95653559
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.95039311
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94822946
57Ras signaling pathway_Homo sapiens_hsa040140.93846018
58Prostate cancer_Homo sapiens_hsa052150.93033988
59Sphingolipid metabolism_Homo sapiens_hsa006000.92993773
60Synaptic vesicle cycle_Homo sapiens_hsa047210.92890260
61Cardiac muscle contraction_Homo sapiens_hsa042600.92775390
62Melanoma_Homo sapiens_hsa052180.92692546
63Pathways in cancer_Homo sapiens_hsa052000.92263914
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91984732
65ErbB signaling pathway_Homo sapiens_hsa040120.89536732
66Arginine and proline metabolism_Homo sapiens_hsa003300.88546459
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88461621
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88216717
69Ovarian steroidogenesis_Homo sapiens_hsa049130.86642117
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85033147
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82715638
72Vitamin B6 metabolism_Homo sapiens_hsa007500.82047265
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80138320
74Long-term potentiation_Homo sapiens_hsa047200.80059811
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79839801
76Estrogen signaling pathway_Homo sapiens_hsa049150.78587996
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.76632167
78Notch signaling pathway_Homo sapiens_hsa043300.76202006
79Endometrial cancer_Homo sapiens_hsa052130.75573676
80Gastric acid secretion_Homo sapiens_hsa049710.74630964
81Lysine degradation_Homo sapiens_hsa003100.73968614
82Glioma_Homo sapiens_hsa052140.73044608
83Cocaine addiction_Homo sapiens_hsa050300.71899826
84Vibrio cholerae infection_Homo sapiens_hsa051100.71606036
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71133237
86Renin secretion_Homo sapiens_hsa049240.71023314
87Salivary secretion_Homo sapiens_hsa049700.70678758
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70639508
89mTOR signaling pathway_Homo sapiens_hsa041500.70255938
90Insulin signaling pathway_Homo sapiens_hsa049100.67293246
91Glutamatergic synapse_Homo sapiens_hsa047240.67163128
92Chronic myeloid leukemia_Homo sapiens_hsa052200.66047988
93Malaria_Homo sapiens_hsa051440.65649646
94Platelet activation_Homo sapiens_hsa046110.65465524
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.62437012
96AMPK signaling pathway_Homo sapiens_hsa041520.62325412
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61709027
98Oxytocin signaling pathway_Homo sapiens_hsa049210.61383877
99GnRH signaling pathway_Homo sapiens_hsa049120.61143227
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.60727209
101Shigellosis_Homo sapiens_hsa051310.60565680
102Serotonergic synapse_Homo sapiens_hsa047260.59113944
103VEGF signaling pathway_Homo sapiens_hsa043700.58484241
104Thyroid hormone synthesis_Homo sapiens_hsa049180.57002348
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56810123
106Salmonella infection_Homo sapiens_hsa051320.56707183
107HIF-1 signaling pathway_Homo sapiens_hsa040660.56469135
108Amphetamine addiction_Homo sapiens_hsa050310.54986890
109Linoleic acid metabolism_Homo sapiens_hsa005910.54909691
110Inositol phosphate metabolism_Homo sapiens_hsa005620.54689887
111MAPK signaling pathway_Homo sapiens_hsa040100.54238940
112Colorectal cancer_Homo sapiens_hsa052100.53430157
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53275532
114Dopaminergic synapse_Homo sapiens_hsa047280.53112651
115GABAergic synapse_Homo sapiens_hsa047270.50870631
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50762862
117Circadian entrainment_Homo sapiens_hsa047130.50546038
118Cholinergic synapse_Homo sapiens_hsa047250.50464600
119Viral myocarditis_Homo sapiens_hsa054160.50460628
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49107970
121Pancreatic cancer_Homo sapiens_hsa052120.47941145
122Pancreatic secretion_Homo sapiens_hsa049720.47455531
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46167641
124cAMP signaling pathway_Homo sapiens_hsa040240.44758992
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41882955
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41754175
127Protein export_Homo sapiens_hsa030600.41252501
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40450235
129Bile secretion_Homo sapiens_hsa049760.40169084
130Choline metabolism in cancer_Homo sapiens_hsa052310.38869830

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