UNC5CL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)7.01540719
2epoxygenase P450 pathway (GO:0019373)6.60289153
3intestinal cholesterol absorption (GO:0030299)6.51545889
4positive regulation of gamma-delta T cell activation (GO:0046645)5.90976318
5regulation of gamma-delta T cell differentiation (GO:0045586)5.70252679
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.55982953
7negative T cell selection (GO:0043383)5.34580668
8regulation of guanylate cyclase activity (GO:0031282)5.25072664
9regulation of bile acid biosynthetic process (GO:0070857)5.24207914
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.22807652
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.22807652
12angiotensin maturation (GO:0002003)5.16508701
13regulation of gamma-delta T cell activation (GO:0046643)5.05255792
14negative thymic T cell selection (GO:0045060)4.98313725
15response to interleukin-15 (GO:0070672)4.96533986
16positive thymic T cell selection (GO:0045059)4.90700624
17fat-soluble vitamin biosynthetic process (GO:0042362)4.89682262
18positive T cell selection (GO:0043368)4.72624252
19antigen processing and presentation of endogenous antigen (GO:0019883)4.67949772
20drug metabolic process (GO:0017144)4.67702916
21NADH metabolic process (GO:0006734)4.67166829
22regulation of T cell tolerance induction (GO:0002664)4.65946910
23very-low-density lipoprotein particle assembly (GO:0034379)4.64877319
24drug catabolic process (GO:0042737)4.54466722
25hormone catabolic process (GO:0042447)4.43203869
26lipoprotein transport (GO:0042953)4.43148826
27regulation of T cell receptor signaling pathway (GO:0050856)4.43010020
28urea metabolic process (GO:0019627)4.40782339
29cellular glucuronidation (GO:0052695)4.40539826
30exogenous drug catabolic process (GO:0042738)4.31176659
31uronic acid metabolic process (GO:0006063)4.30864284
32glucuronate metabolic process (GO:0019585)4.30864284
33thymic T cell selection (GO:0045061)4.26949605
34T cell selection (GO:0045058)4.24797035
35urea cycle (GO:0000050)4.23113466
36diacylglycerol metabolic process (GO:0046339)4.21568418
37fructose metabolic process (GO:0006000)4.21397195
38T cell costimulation (GO:0031295)4.15513717
39nitrogen cycle metabolic process (GO:0071941)4.07030483
40regulation of cellular extravasation (GO:0002691)4.05765610
41lymphocyte costimulation (GO:0031294)4.05045288
42positive regulation of tolerance induction (GO:0002645)4.03602331
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.02682205
44negative regulation of cell killing (GO:0031342)4.02682205
45regulation of isotype switching to IgG isotypes (GO:0048302)4.00527534
46regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.00504755
47positive regulation of guanylate cyclase activity (GO:0031284)3.99723446
48UDP-N-acetylglucosamine metabolic process (GO:0006047)3.88226137
49regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.85712487
50endocrine process (GO:0050886)3.85712487
51regulation of systemic arterial blood pressure by hormone (GO:0001990)3.85712487
52regulation of cholesterol esterification (GO:0010872)3.85518492
53cellular response to interleukin-15 (GO:0071350)3.81907941
54complement activation, alternative pathway (GO:0006957)3.81618862
55regulation of protein activation cascade (GO:2000257)3.80960563
56complement activation, classical pathway (GO:0006958)3.79731436
57mucosal-associated lymphoid tissue development (GO:0048537)3.77663552
58Peyers patch development (GO:0048541)3.77663552
59peptide hormone processing (GO:0016486)3.76753661
60bile acid and bile salt transport (GO:0015721)3.76585429
61regulation of complement activation (GO:0030449)3.76139681
62ethanol oxidation (GO:0006069)3.75637373
63protein-lipid complex remodeling (GO:0034368)3.73832491
64macromolecular complex remodeling (GO:0034367)3.73832491
65plasma lipoprotein particle remodeling (GO:0034369)3.73832491
66positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.71674099
67high-density lipoprotein particle remodeling (GO:0034375)3.70629726
68negative regulation of T cell receptor signaling pathway (GO:0050860)3.68023021
69regulation of oxidative stress-induced neuron death (GO:1903203)3.67511788
70arginine metabolic process (GO:0006525)3.63255318
71alkaloid metabolic process (GO:0009820)3.62765932
72triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.62625417
73peptide catabolic process (GO:0043171)3.61278769
74negative regulation of thymocyte apoptotic process (GO:0070244)3.61191252
75interferon-gamma production (GO:0032609)3.58802084
76digestion (GO:0007586)3.57167273
77vitamin A metabolic process (GO:0006776)3.56771133
78T cell receptor signaling pathway (GO:0050852)3.56152191
79negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.55870061
80regulation of cholesterol homeostasis (GO:2000188)3.53977327
81hepatocyte apoptotic process (GO:0097284)3.53879840
82bile acid metabolic process (GO:0008206)3.51296601
83plasma lipoprotein particle organization (GO:0071827)3.49262305
84positive regulation of interleukin-2 production (GO:0032743)3.46870008
85regulation of systemic arterial blood pressure (GO:0003073)3.44173572
86regulation of tolerance induction (GO:0002643)3.43764188
87fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.42871417
88complement activation (GO:0006956)3.38962231
89phenylpropanoid metabolic process (GO:0009698)3.38088020
90regulation of cGMP biosynthetic process (GO:0030826)3.37504732
91omega-hydroxylase P450 pathway (GO:0097267)3.37155617
92lipoprotein metabolic process (GO:0042157)3.37120571
93protein-lipid complex subunit organization (GO:0071825)3.30886338
94phospholipid scrambling (GO:0017121)3.30781854
95reverse cholesterol transport (GO:0043691)3.30282250
96dendritic cell chemotaxis (GO:0002407)3.29602527
97positive regulation of lipid catabolic process (GO:0050996)3.27771451
98regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.27397630
99leukocyte aggregation (GO:0070486)3.26361629
100regulation of response to interferon-gamma (GO:0060330)3.25422734
101positive regulation of response to oxidative stress (GO:1902884)3.24916775
102positive regulation of cellular response to oxidative stress (GO:1900409)3.24916775
103cholesterol efflux (GO:0033344)3.24701330
104digestive system process (GO:0022600)3.23719260
105flavonoid metabolic process (GO:0009812)3.23067789
106glycolipid catabolic process (GO:0019377)3.22375206
107acute-phase response (GO:0006953)3.19280267
108regulation of histone H3-K27 methylation (GO:0061085)3.18505566
109antigen receptor-mediated signaling pathway (GO:0050851)3.17555182
110regulation of B cell receptor signaling pathway (GO:0050855)3.16997881
111positive regulation of keratinocyte differentiation (GO:0045618)3.15502204
112positive regulation of isotype switching (GO:0045830)3.14257800
113vitamin transport (GO:0051180)3.11791666
114regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.10484924
115receptor guanylyl cyclase signaling pathway (GO:0007168)3.10120484
116positive regulation of fatty acid biosynthetic process (GO:0045723)3.09259589
117glycosphingolipid catabolic process (GO:0046479)3.08186640
118protein activation cascade (GO:0072376)3.07806556
119antibacterial humoral response (GO:0019731)3.06037667
120low-density lipoprotein particle remodeling (GO:0034374)3.04373879
121antimicrobial humoral response (GO:0019730)3.03820740
122drug transport (GO:0015893)3.02832729
123regulation of extracellular matrix disassembly (GO:0010715)3.02696899
124regulation of cholesterol metabolic process (GO:0090181)3.02653838
125plasma lipoprotein particle assembly (GO:0034377)3.01798718
126trophectodermal cell differentiation (GO:0001829)3.00496393
127mature B cell differentiation (GO:0002335)3.00064828
128positive regulation of histone deacetylation (GO:0031065)2.97293081
129virion attachment to host cell (GO:0019062)2.95098946
130adhesion of symbiont to host cell (GO:0044650)2.95098946
131auditory receptor cell differentiation (GO:0042491)2.94466051
132T cell migration (GO:0072678)2.93808843
133maintenance of gastrointestinal epithelium (GO:0030277)2.91929558
134dendritic cell migration (GO:0036336)2.91318535
135positive regulation of T cell differentiation in thymus (GO:0033089)2.91073500
136cholesterol homeostasis (GO:0042632)2.90828609
137glutamine family amino acid biosynthetic process (GO:0009084)2.90688315
138negative regulation of cholesterol transport (GO:0032375)2.89689011
139negative regulation of sterol transport (GO:0032372)2.89689011
140drug transmembrane transport (GO:0006855)2.89487653
141angiogenesis involved in wound healing (GO:0060055)2.88577290
142ethanol metabolic process (GO:0006067)2.88387207
143regulation of regulatory T cell differentiation (GO:0045589)2.88152785
144positive regulation of pseudopodium assembly (GO:0031274)2.87867030
145regulation of alpha-beta T cell proliferation (GO:0046640)2.86477486
146sterol homeostasis (GO:0055092)2.85394575
147T cell differentiation (GO:0030217)2.85153440
148protein-lipid complex assembly (GO:0065005)2.85068348
149purine nucleotide salvage (GO:0032261)2.84195049
150embryonic process involved in female pregnancy (GO:0060136)2.82978097
151regulation of fibrinolysis (GO:0051917)2.79975874
152L-ascorbic acid metabolic process (GO:0019852)2.79715607
153renal system process involved in regulation of blood volume (GO:0001977)2.79713900
154mature B cell differentiation involved in immune response (GO:0002313)2.79711831
155alpha-beta T cell activation (GO:0046631)2.79515004
156ganglioside metabolic process (GO:0001573)2.78661191
157positive regulation of respiratory burst (GO:0060267)2.78206781
158V(D)J recombination (GO:0033151)2.78020215
159leukocyte cell-cell adhesion (GO:0007159)2.77229839
160regulation of respiratory burst (GO:0060263)2.76798883
161regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.76250933
162cellular response to hepatocyte growth factor stimulus (GO:0035729)2.75666919
163response to hepatocyte growth factor (GO:0035728)2.75666919
164T cell activation (GO:0042110)2.74461004
165activated T cell proliferation (GO:0050798)2.73010335
166regulation of interleukin-2 biosynthetic process (GO:0045076)2.72495912
167myoblast migration (GO:0051451)2.72263328
168positive regulation of DNA recombination (GO:0045911)2.71951462
169positive regulation of triglyceride lipase activity (GO:0061365)2.71890163
170positive regulation of lipoprotein lipase activity (GO:0051006)2.71890163
171positive regulation of calcium-mediated signaling (GO:0050850)2.71045323
172phospholipid efflux (GO:0033700)2.70608038
173regulation of isotype switching (GO:0045191)2.70127122
174positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.69256346
175sialylation (GO:0097503)2.68744099
176sulfate transmembrane transport (GO:1902358)2.68701644
177actin filament depolymerization (GO:0030042)2.68274405
178purine deoxyribonucleotide catabolic process (GO:0009155)2.68134605
179B cell receptor signaling pathway (GO:0050853)2.67154635
180glycosphingolipid biosynthetic process (GO:0006688)2.66870428
181T cell homeostasis (GO:0043029)2.66776242
182epithelial structure maintenance (GO:0010669)2.63744056
183lymphocyte homeostasis (GO:0002260)2.59912655
184regulation of triglyceride catabolic process (GO:0010896)2.59726020

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.19369040
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.81529192
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.62827480
4E2F7_22180533_ChIP-Seq_HELA_Human4.10836654
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.65431427
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.33761601
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.12278419
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.10566971
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.09743609
10RUNX_20019798_ChIP-Seq_JUKART_Human3.08972646
11MYB_26560356_Chip-Seq_TH2_Human2.86038001
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.85587095
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.82349908
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.76037443
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.72549647
16MAF_26560356_Chip-Seq_TH1_Human2.70252451
17MYC_22102868_ChIP-Seq_BL_Human2.69185794
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.68982592
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.62492919
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.48134765
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.48112931
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.47933296
23UTX_26944678_Chip-Seq_JUKART_Human2.37528731
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.34273890
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.33569044
26CDX2_20551321_ChIP-Seq_CACO-2_Human2.28007150
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26685580
28MYB_26560356_Chip-Seq_TH1_Human2.25764798
29GATA1_22025678_ChIP-Seq_K562_Human2.20808069
30IRF8_21731497_ChIP-ChIP_J774_Mouse2.09484913
31VDR_21846776_ChIP-Seq_THP-1_Human2.07214993
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03857664
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.01987086
34* LXR_22292898_ChIP-Seq_THP-1_Human1.93966956
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.93367303
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.90111669
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.87965628
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85357578
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82057026
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.77472821
41SCL_19346495_ChIP-Seq_HPC-7_Human1.76062160
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73651781
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72311134
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.72075819
45* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69265102
46* GATA6_25053715_ChIP-Seq_YYC3_Human1.65006866
47TCF7_22412390_ChIP-Seq_EML_Mouse1.63657254
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61625961
49MAF_26560356_Chip-Seq_TH2_Human1.61061842
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59212143
51* FOXA2_19822575_ChIP-Seq_HepG2_Human1.59010327
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58711546
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55939064
54* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54925158
55* GATA3_27048872_Chip-Seq_THYMUS_Human1.54570021
56VDR_24763502_ChIP-Seq_THP-1_Human1.54475630
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54246589
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53604990
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.52901347
60SPI1_23127762_ChIP-Seq_K562_Human1.52360632
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47039147
62* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46866358
63* HNF4A_19822575_ChIP-Seq_HepG2_Human1.44893750
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44244417
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43980503
66PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.43755920
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43486615
68* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43465533
69SPI1_23547873_ChIP-Seq_NB4_Human1.43162787
70* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42354393
71* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41865265
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41787382
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.38430940
74* KDM2B_26808549_Chip-Seq_DND41_Human1.37492474
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.36632701
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.35855336
77BCOR_27268052_Chip-Seq_Bcells_Human1.34407119
78* GATA2_19941826_ChIP-Seq_K562_Human1.33231073
79FOXM1_23109430_ChIP-Seq_U2OS_Human1.33128513
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31619699
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30585609
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29629272
83GATA4_25053715_ChIP-Seq_YYC3_Human1.29420336
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27648001
85CIITA_25753668_ChIP-Seq_RAJI_Human1.24591328
86GATA1_19941826_ChIP-Seq_K562_Human1.24400907
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23298061
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22188584
89FOXA1_25552417_ChIP-Seq_VCAP_Human1.20587065
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18312156
91BCL6_27268052_Chip-Seq_Bcells_Human1.17816924
92PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17211503
93FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15302955
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14985431
95BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.13448024
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12003493
97FOXO3_23340844_ChIP-Seq_DLD1_Human1.10665164
98SA1_27219007_Chip-Seq_Bcells_Human1.09812728
99TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09148102
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08722839
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08562296
102PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07889419
103FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07605655
104CTCF_27219007_Chip-Seq_Bcells_Human1.07581890
105RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06374285
106RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05233814
107SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04931651
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04373260
109* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03678152
110KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02711898
111ESR2_21235772_ChIP-Seq_MCF-7_Human1.02430455
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02145079
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01260551
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00575869
115TCF4_18268006_ChIP-ChIP_LS174T_Human0.99677810
116PU_27001747_Chip-Seq_BMDM_Mouse0.98950374
117RUNX1_27514584_Chip-Seq_MCF-7_Human0.98731881
118PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98323151
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98051367
120P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96626517
121NCOR1_26117541_ChIP-Seq_K562_Human0.96533680
122SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95935761
123P68_20966046_ChIP-Seq_HELA_Human0.95027571
124CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94701591
125TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94188386
126TET1_21451524_ChIP-Seq_MESCs_Mouse0.93964445
127KDM2B_26808549_Chip-Seq_JURKAT_Human0.93407676
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93347282
129ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93328421
130LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93221079
131CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92706299
132PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91962911
133GATA3_26560356_Chip-Seq_TH2_Human0.91562616
134PHF8_20622854_ChIP-Seq_HELA_Human0.90277662
135DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89965750
136E2F1_20622854_ChIP-Seq_HELA_Human0.88746993
137RACK7_27058665_Chip-Seq_MCF-7_Human0.88499831
138ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88091594
139ESR1_21235772_ChIP-Seq_MCF-7_Human0.88081694
140* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.87572776
141NANOG_20526341_ChIP-Seq_ESCs_Human0.86934600
142CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86865734
143P300_27268052_Chip-Seq_Bcells_Human0.86540672
144E2F4_17652178_ChIP-ChIP_JURKAT_Human0.85498313
145CEBPB_22108803_ChIP-Seq_LS180_Human0.84990860
146* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84317767
147CLOCK_20551151_ChIP-Seq_293T_Human0.83304518
148CREB1_26743006_Chip-Seq_LNCaP_Human0.83282140
149SOX2_20726797_ChIP-Seq_SW620_Human0.83262253
150CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83062418
151* ELF5_23300383_ChIP-Seq_T47D_Human0.82674545
152ELK3_25401928_ChIP-Seq_HUVEC_Human0.82353950
153* KLF5_25053715_ChIP-Seq_YYC3_Human0.82214010
154HIF1A_21447827_ChIP-Seq_MCF-7_Human0.81918093
155SA1_27219007_Chip-Seq_ERYTHROID_Human0.81766619
156NOTCH1_21737748_ChIP-Seq_TLL_Human0.81576840
157CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81467367
158SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80047512
159EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79972942
160* TP63_22573176_ChIP-Seq_HFKS_Human0.79901022
161IKZF1_21737484_ChIP-ChIP_HCT116_Human0.79784119

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.98224323
2MP0003763_abnormal_thymus_physiology3.55089615
3MP0001666_abnormal_nutrient_absorption3.48355345
4MP0003866_abnormal_defecation3.15146202
5MP0004264_abnormal_extraembryonic_tissu3.09432783
6MP0010155_abnormal_intestine_physiology2.97083987
7MP0005671_abnormal_response_to2.92392656
8MP0000685_abnormal_immune_system2.90926106
9MP0001800_abnormal_humoral_immune2.85957645
10MP0002138_abnormal_hepatobiliary_system2.69551728
11MP0001835_abnormal_antigen_presentation2.62524952
12MP0009840_abnormal_foam_cell2.55293048
13MP0003300_gastrointestinal_ulcer2.46905398
14MP0001873_stomach_inflammation2.46355966
15MP0005387_immune_system_phenotype2.37641340
16MP0001790_abnormal_immune_system2.37641340
17MP0004947_skin_inflammation2.26216655
18MP0002398_abnormal_bone_marrow2.25683821
19MP0010234_abnormal_vibrissa_follicle2.23962666
20MP0000490_abnormal_crypts_of2.20809369
21MP0002452_abnormal_antigen_presenting2.20321446
22MP0002420_abnormal_adaptive_immunity2.19402834
23MP0005332_abnormal_amino_acid2.19050443
24MP0001819_abnormal_immune_cell2.17942803
25MP0003656_abnormal_erythrocyte_physiolo2.10825727
26MP0002723_abnormal_immune_serum2.10662535
27MP0002166_altered_tumor_susceptibility1.99382661
28MP0000716_abnormal_immune_system1.98428614
29MP0009333_abnormal_splenocyte_physiolog1.94510961
30MP0003195_calcinosis1.91322968
31MP0000703_abnormal_thymus_morphology1.90813025
32MP0003868_abnormal_feces_composition1.90556946
33MP0005000_abnormal_immune_tolerance1.88968411
34MP0003183_abnormal_peptide_metabolism1.88613685
35MP0005025_abnormal_response_to1.87964101
36MP0002722_abnormal_immune_system1.84853922
37MP0009379_abnormal_foot_pigmentation1.84369545
38MP0006082_CNS_inflammation1.83906287
39MP0002405_respiratory_system_inflammati1.83495060
40MP0010352_gastrointestinal_tract_polyps1.82611797
41MP0002132_abnormal_respiratory_system1.77307785
42MP0002429_abnormal_blood_cell1.72439949
43MP0002396_abnormal_hematopoietic_system1.70980735
44MP0004147_increased_porphyrin_level1.69890719
45MP0006054_spinal_hemorrhage1.69651108
46MP0000689_abnormal_spleen_morphology1.66795095
47MP0009785_altered_susceptibility_to1.65678189
48MP0002118_abnormal_lipid_homeostasis1.60778718
49MP0005409_darkened_coat_color1.54531478
50MP0002148_abnormal_hypersensitivity_rea1.54099324
51MP0001764_abnormal_homeostasis1.52010727
52MP0001664_abnormal_digestion1.50895731
53MP0003252_abnormal_bile_duct1.48846533
54MP0003879_abnormal_hair_cell1.48342049
55MP0005464_abnormal_platelet_physiology1.45528290
56MP0002006_tumorigenesis1.45271018
57MP0001663_abnormal_digestive_system1.44314902
58MP0001845_abnormal_inflammatory_respons1.43607931
59MP0003191_abnormal_cellular_cholesterol1.43128571
60MP0003724_increased_susceptibility_to1.42636156
61MP0000462_abnormal_digestive_system1.42148403
62MP0000477_abnormal_intestine_morphology1.35884979
63MP0000678_abnormal_parathyroid_gland1.33451727
64MP0000858_altered_metastatic_potential1.31059651
65MP0005166_decreased_susceptibility_to1.29727112
66MP0003436_decreased_susceptibility_to1.27636980
67MP0005310_abnormal_salivary_gland1.24101075
68MP0001756_abnormal_urination1.22908892
69MP0005381_digestive/alimentary_phenotyp1.21419162
70MP0010329_abnormal_lipoprotein_level1.18831641
71MP0002419_abnormal_innate_immunity1.16987881
72MP0002009_preneoplasia1.16161250
73MP0005058_abnormal_lysosome_morphology1.14741559
74MP0005451_abnormal_body_composition1.14386853
75MP0005085_abnormal_gallbladder_physiolo1.12111296
76MP0003693_abnormal_embryo_hatching1.09883893
77MP0002139_abnormal_hepatobiliary_system1.09401578
78MP0003045_fibrosis1.07779238
79MP0002971_abnormal_brown_adipose1.06006649
80MP0004858_abnormal_nervous_system1.05062232
81MP0005319_abnormal_enzyme/_coenzyme0.99882993
82MP0004185_abnormal_adipocyte_glucose0.99405318
83MP0000609_abnormal_liver_physiology0.98149146
84MP0004782_abnormal_surfactant_physiolog0.96889737
85MP0002933_joint_inflammation0.96045492
86MP0000538_abnormal_urinary_bladder0.95463797
87MP0008961_abnormal_basal_metabolism0.94610756
88MP0009643_abnormal_urine_homeostasis0.94331977
89MP0009642_abnormal_blood_homeostasis0.94108862
90MP0002078_abnormal_glucose_homeostasis0.93728663
91MP0004808_abnormal_hematopoietic_stem0.91563567
92MP0005535_abnormal_body_temperature0.91321783
93MP0005584_abnormal_enzyme/coenzyme_acti0.90834418
94MP0002909_abnormal_adrenal_gland0.89967061
95MP0008469_abnormal_protein_level0.86236730
96MP0001501_abnormal_sleep_pattern0.84709966
97MP0002876_abnormal_thyroid_physiology0.83670823
98MP0005076_abnormal_cell_differentiation0.82872813
99MP0004043_abnormal_pH_regulation0.81996222
100MP0003453_abnormal_keratinocyte_physiol0.81450878
101MP0002822_catalepsy0.81156105
102MP0008004_abnormal_stomach_pH0.79541481
103MP0009765_abnormal_xenobiotic_induced0.78868770
104MP0000604_amyloidosis0.78058842
105MP0003806_abnormal_nucleotide_metabolis0.76983839
106MP0002136_abnormal_kidney_physiology0.76088332
107MP0002693_abnormal_pancreas_physiology0.74752240
108MP0001851_eye_inflammation0.72577180
109MP0002019_abnormal_tumor_incidence0.72569420
110MP0003953_abnormal_hormone_level0.71775853
111MP0005448_abnormal_energy_balance0.71081998
112MP0008875_abnormal_xenobiotic_pharmacok0.70560598
113MP0004019_abnormal_vitamin_homeostasis0.69801418
114MP0001765_abnormal_ion_homeostasis0.69263116
115MP0005334_abnormal_fat_pad0.68283193
116MP0001849_ear_inflammation0.67634766
117MP0003172_abnormal_lysosome_physiology0.67250244
118MP0003448_altered_tumor_morphology0.67109994
119MP0002254_reproductive_system_inflammat0.66308030
120MP0003303_peritoneal_inflammation0.66055570
121MP0001485_abnormal_pinna_reflex0.66038460
122MP0005670_abnormal_white_adipose0.64719034
123MP0009115_abnormal_fat_cell0.63765818
124MP0001533_abnormal_skeleton_physiology0.63512351
125MP0003329_amyloid_beta_deposits0.63263501
126MP0001216_abnormal_epidermal_layer0.63090261
127MP0001853_heart_inflammation0.62463913
128MP0000230_abnormal_systemic_arterial0.61622762
129MP0001881_abnormal_mammary_gland0.61310001
130MP0000598_abnormal_liver_morphology0.61015778
131MP0004957_abnormal_blastocyst_morpholog0.59316389
132MP0008872_abnormal_physiological_respon0.59174302
133MP0003638_abnormal_response/metabolism_0.59045602
134MP0000249_abnormal_blood_vessel0.58923979
135MP0000537_abnormal_urethra_morphology0.58847280
136MP0002089_abnormal_postnatal_growth/wei0.57030835
137MP0005174_abnormal_tail_pigmentation0.56735100
138MP0005636_abnormal_mineral_homeostasis0.56471055
139MP0001944_abnormal_pancreas_morphology0.56137760
140MP0009764_decreased_sensitivity_to0.55390400
141MP0002796_impaired_skin_barrier0.55226887
142MP0005365_abnormal_bile_salt0.54211806
143MP0000566_synostosis0.53955580
144MP0001191_abnormal_skin_condition0.53526368
145MP0002998_abnormal_bone_remodeling0.53000668
146MP0003111_abnormal_nucleus_morphology0.52694255

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)6.11129858
2B lymphocytopenia (HP:0010976)5.33755215
3Abnormality of B cell number (HP:0010975)5.33755215
4Systemic lupus erythematosus (HP:0002725)5.26792128
5Severe combined immunodeficiency (HP:0004430)5.08724779
6Acanthocytosis (HP:0001927)5.07810846
7Autoimmune thrombocytopenia (HP:0001973)5.05145031
8T lymphocytopenia (HP:0005403)5.04185194
9Combined immunodeficiency (HP:0005387)4.94608301
10Abnormality of T cell number (HP:0011839)4.84507598
11Complement deficiency (HP:0004431)4.81610182
12Fat malabsorption (HP:0002630)4.72796213
13Pustule (HP:0200039)4.68297223
14Abnormality of monocarboxylic acid metabolism (HP:0010996)4.60068021
15Recurrent viral infections (HP:0004429)4.51275189
16Ileus (HP:0002595)4.46894744
17Nasal polyposis (HP:0100582)4.33419856
18Xanthomatosis (HP:0000991)4.25682864
19Abnormality of complement system (HP:0005339)4.20519066
20Panhypogammaglobulinemia (HP:0003139)4.03259413
21Thyroiditis (HP:0100646)3.98248966
22Abnormality of T cells (HP:0002843)3.94747148
23Recurrent fungal infections (HP:0002841)3.84805443
24Chronic diarrhea (HP:0002028)3.79181467
25Recurrent bronchitis (HP:0002837)3.74079975
26Poikilocytosis (HP:0004447)3.71043597
27IgM deficiency (HP:0002850)3.65720860
28Steatorrhea (HP:0002570)3.64115557
29Glomerulonephritis (HP:0000099)3.61734885
30Abnormality of vitamin B metabolism (HP:0004340)3.57695081
31Eosinophilia (HP:0001880)3.57092561
32Recurrent sinusitis (HP:0011108)3.56815183
33Widely patent fontanelles and sutures (HP:0004492)3.51326814
34Hypobetalipoproteinemia (HP:0003563)3.44540069
35Abnormality of the nasal mucosa (HP:0000433)3.43555218
36Abnormality of the vitamin B12 metabolism (HP:0004341)3.42967842
37Abnormality of vitamin metabolism (HP:0100508)3.42741583
38Chronic otitis media (HP:0000389)3.34592875
39Abnormal delayed hypersensitivity skin test (HP:0002963)3.31551838
40Abnormality of eosinophils (HP:0001879)3.30555501
41Agammaglobulinemia (HP:0004432)3.29687203
42Deep venous thrombosis (HP:0002625)3.27995259
43Abnormality of urine glucose concentration (HP:0011016)3.25727286
44Glycosuria (HP:0003076)3.25727286
45Inflammation of the large intestine (HP:0002037)3.23968412
46Increased IgE level (HP:0003212)3.19470172
47Colitis (HP:0002583)3.12041018
48Gastrointestinal inflammation (HP:0004386)3.06810269
49Abnormality of glutamine family amino acid metabolism (HP:0010902)3.05740945
50Granulocytopenia (HP:0001913)3.03613288
51Potter facies (HP:0002009)3.02076143
52Facial shape deformation (HP:0011334)3.02076143
53Abnormality of aromatic amino acid family metabolism (HP:0004338)3.01638080
54Congenital sensorineural hearing impairment (HP:0008527)2.99540060
55Elevated erythrocyte sedimentation rate (HP:0003565)2.99247852
56Lymphopenia (HP:0001888)2.96495284
57Hyperlipoproteinemia (HP:0010980)2.90830583
58Abnormality of cells of the lymphoid lineage (HP:0012140)2.90338101
59Abnormality of T cell physiology (HP:0011840)2.87627822
60Hemorrhage of the eye (HP:0011885)2.87172297
61Hyperglycinuria (HP:0003108)2.84811810
62Prolonged partial thromboplastin time (HP:0003645)2.84278633
63Proximal tubulopathy (HP:0000114)2.80211937
64IgG deficiency (HP:0004315)2.78983452
65Nephritis (HP:0000123)2.78958107
66Hypophosphatemia (HP:0002148)2.76057558
67Toxemia of pregnancy (HP:0100603)2.75537324
68Confusion (HP:0001289)2.75343144
69Alveolar cell carcinoma (HP:0006519)2.69947171
70Easy fatigability (HP:0003388)2.68253722
71Papilloma (HP:0012740)2.67875178
72Verrucae (HP:0200043)2.67875178
73Chronic mucocutaneous candidiasis (HP:0002728)2.66759257
74Recurrent cutaneous fungal infections (HP:0011370)2.66759257
75Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.61735156
76Abnormality of serine family amino acid metabolism (HP:0010894)2.61615077
77Abnormality of glycine metabolism (HP:0010895)2.61615077
78Abnormality of the fingertips (HP:0001211)2.58950042
79Cheilitis (HP:0100825)2.55479704
80Volvulus (HP:0002580)2.54551997
81Recurrent gram-negative bacterial infections (HP:0005420)2.53566768
82Neoplasm of the tracheobronchial system (HP:0100552)2.50190003
83Bronchiectasis (HP:0002110)2.50052606
84Intrahepatic cholestasis (HP:0001406)2.49804540
85Thin bony cortex (HP:0002753)2.47031010
86Villous atrophy (HP:0011473)2.46990360
87Abnormality of small intestinal villus morphology (HP:0011472)2.46990360
88Hyperuricemia (HP:0002149)2.46167667
89Increased purine levels (HP:0004368)2.46167667
90Leukocytosis (HP:0001974)2.43135066
91Alkalosis (HP:0001948)2.43108408
92Epidermoid cyst (HP:0200040)2.39137548
93Nephrolithiasis (HP:0000787)2.38354388
94Hypoproteinemia (HP:0003075)2.38080099
95Hyperphosphaturia (HP:0003109)2.37876886
96Hyperammonemia (HP:0001987)2.36489824
97Encephalitis (HP:0002383)2.35543056
98Joint hemorrhage (HP:0005261)2.35373096
99Chronic sinusitis (HP:0011109)2.34509881
100Gout (HP:0001997)2.34247029
101Eczematoid dermatitis (HP:0000976)2.33286526
102Abnormal platelet volume (HP:0011876)2.33249440
103Abnormal urine phosphate concentration (HP:0012599)2.32698398
104Gastrointestinal stroma tumor (HP:0100723)2.30551613
105Reticulocytosis (HP:0001923)2.29867362
106Cerebral palsy (HP:0100021)2.27482728
107Meningitis (HP:0001287)2.27172846
108Decreased circulating renin level (HP:0003351)2.26557551
109Metabolic alkalosis (HP:0200114)2.26548632
110Bronchitis (HP:0012387)2.26197036
111Abnormality of pyrimidine metabolism (HP:0004353)2.26115195
112Abnormality of nucleobase metabolism (HP:0010932)2.24550529
113IgA deficiency (HP:0002720)2.24144734
114Abnormality of purine metabolism (HP:0004352)2.23833390
115Protuberant abdomen (HP:0001538)2.23761812
116Pili torti (HP:0003777)2.22967059
117Wide cranial sutures (HP:0010537)2.21834539
118Pancreatitis (HP:0001733)2.21510412
119Nausea (HP:0002018)2.19958736
120Increased mean platelet volume (HP:0011877)2.17863668
121Abnormality of the heme biosynthetic pathway (HP:0010472)2.16696816
122Hypotension (HP:0002615)2.16209695
123Myositis (HP:0100614)2.16189256
124Abnormality of proline metabolism (HP:0010907)2.15175953
125Hydroxyprolinuria (HP:0003080)2.15175953
126Hyperphosphatemia (HP:0002905)2.13780540
127Vascular calcification (HP:0004934)2.13047627
128Recurrent otitis media (HP:0000403)2.12572441
129Malnutrition (HP:0004395)2.10521796
130Focal segmental glomerulosclerosis (HP:0000097)2.10229895
131Exocrine pancreatic insufficiency (HP:0001738)2.10186550
132Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08514374
133Megaloblastic anemia (HP:0001889)2.07521853
134Abnormality of the gastric mucosa (HP:0004295)2.05864154
135Late onset (HP:0003584)2.05789912
136Hypoplasia of the thymus (HP:0000778)2.04618388
137Gastrointestinal dysmotility (HP:0002579)2.03861030
138Fatigable weakness (HP:0003473)2.03753629
139Abnormality of the neuromuscular junction (HP:0003398)2.03753629
140Abnormality of the common coagulation pathway (HP:0010990)2.01793058
141Abdominal distention (HP:0003270)2.00815301
142Metabolic acidosis (HP:0001942)2.00135609
143Recurrent abscess formation (HP:0002722)1.99043805
144Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97586316
145Hypolipoproteinemia (HP:0010981)1.97463356
146Growth hormone excess (HP:0000845)1.96718175
147Gingival bleeding (HP:0000225)1.96129034
148Lymphoma (HP:0002665)1.95529482
149Conjugated hyperbilirubinemia (HP:0002908)1.93292787
150Abnormality of magnesium homeostasis (HP:0004921)1.92779141
151Abnormality of oral frenula (HP:0000190)1.92387354
152Symptomatic seizures (HP:0011145)1.91690433
153Cupped ribs (HP:0000887)1.90430180
154Abnormality of renin-angiotensin system (HP:0000847)1.90243460
155Thrombocytosis (HP:0001894)1.89846641
156Rickets (HP:0002748)1.89103776
157Rectal prolapse (HP:0002035)1.88430239
158Hyperparathyroidism (HP:0000843)1.88091170
159Abnormal pancreas size (HP:0012094)1.87208788
160Abnormality of macrophages (HP:0004311)1.86307758
161Disinhibition (HP:0000734)1.86285932
162Urinary glycosaminoglycan excretion (HP:0003541)1.84850922
163Mucopolysacchariduria (HP:0008155)1.84850922
164Hyperactive renin-angiotensin system (HP:0000841)1.84522238
165Abnormality of alkaline phosphatase activity (HP:0004379)1.84363274
166Abnormal enzyme/coenzyme activity (HP:0012379)1.84196374
167Pigmentary retinal degeneration (HP:0001146)1.84132136
168Aplasia/Hypoplasia of the thymus (HP:0010515)1.83322564
169Cellulitis (HP:0100658)1.81144218
170Amyloidosis (HP:0011034)1.80888744
171Seborrheic dermatitis (HP:0001051)1.80502899
172Gingivitis (HP:0000230)1.80220201
173Hepatitis (HP:0012115)1.79681910
174Vacuolated lymphocytes (HP:0001922)1.79213361
175Abnormality of reticulocytes (HP:0004312)1.77181647
176Osteomalacia (HP:0002749)1.77080465
177Vasculitis (HP:0002633)1.76441376
178Viral hepatitis (HP:0006562)1.76144485
179Irritability (HP:0000737)1.75127848
180Abnormal glucose tolerance (HP:0001952)1.74692725
181Joint swelling (HP:0001386)1.74609213
182Spontaneous hematomas (HP:0007420)1.74143061
183Recurrent skin infections (HP:0001581)1.74039599
184Petechiae (HP:0000967)1.72292183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.42923931
2BMPR24.23485861
3MST44.22269310
4ACVR1B4.19641820
5GRK63.51404034
6STK103.26641716
7TXK3.17592134
8ITK2.87203411
9MAP3K102.74224261
10LMTK22.22776300
11DMPK2.19897898
12ZAP702.14332003
13FGFR42.14036139
14JAK32.10675892
15TYK21.97957778
16NUAK11.83699642
17ERN11.72288439
18EEF2K1.71476897
19FRK1.70015558
20IKBKE1.65232133
21NLK1.57579992
22MAP3K11.57301137
23STK241.54286936
24PRPF4B1.50874196
25LRRK21.50291935
26MAPK151.49137879
27CSK1.47413823
28PRKG21.46611324
29PTK61.46561326
30IKBKB1.41928309
31BLK1.33510515
32TBK11.32000174
33JAK11.30996223
34TRIB31.29520189
35FGFR31.28864601
36SYK1.24147628
37TAOK11.23322839
38MET1.21435717
39CDC42BPA1.20827213
40LCK1.19829943
41SIK11.12966602
42TNIK1.11839782
43CDK121.11766208
44NME11.10896387
45STK391.06493834
46MAP3K111.05733218
47PDPK10.97631463
48TEC0.96803818
49PRKD20.93842159
50PRKCQ0.92534099
51OXSR10.91185110
52NME20.90503938
53MAP3K30.89889067
54PRKAA20.89851982
55PIM10.88020384
56CDK90.87211000
57IRAK40.86243573
58GSK3A0.86056400
59BTK0.85668714
60MAPK110.83472469
61FER0.83196626
62MELK0.82418007
63MAP3K80.82315255
64FGFR20.82047887
65MAP2K20.80016552
66MAP3K140.79734080
67MAP3K130.78746185
68DYRK1B0.78621124
69EPHB10.78598382
70CLK10.78421033
71CDK40.76837009
72TYRO30.76164067
73DDR20.75277661
74MST1R0.74945110
75DAPK20.74663744
76STK40.74045546
77PIK3CG0.73197771
78MAP3K70.71157664
79BMX0.70815731
80TLK10.70714683
81MAP3K120.70711257
82JAK20.67336709
83HCK0.66377226
84MAP2K60.66187658
85TGFBR20.66084659
86PDGFRB0.64008614
87MATK0.63477710
88PIK3CA0.63356282
89RET0.62266180
90MAPKAPK30.61926768
91HIPK20.61318172
92FLT30.60158496
93MARK20.60148734
94PRKCH0.59482308
95CHUK0.58178663
96PRKCZ0.58013452
97TESK10.57341863
98ERBB20.57117619
99TRPM70.55709316
100KIT0.54367725
101EPHA30.53654495
102YES10.53217229
103LYN0.51449721
104PRKACG0.51088668
105RPS6KA40.49974993
106EIF2AK10.49462901
107ALK0.49429118
108PRKCI0.49294953
109CDK60.47477639
110PKN20.47394339
111MAP3K50.46811485
112SIK20.46693756
113KSR20.44137241
114CSF1R0.43200245
115TAOK30.42544956
116MAPK70.42537551
117PAK40.42505014
118PDK10.40245685
119MAPK30.39554436
120TESK20.38834725
121ICK0.38594739
122SRC0.38277916
123NTRK30.38032020
124IRAK10.37754441
125MAPKAPK20.35781098
126INSR0.33528956
127EPHA20.33294895
128FGR0.32874687
129RPS6KB20.32742025
130RIPK40.32528634
131CAMKK20.32032100
132SCYL20.31822938
133PRKCA0.30652043
134SMG10.30388265
135AKT30.30169721
136TNK20.30129565
137KDR0.29410112
138PAK10.28603352
139PTK20.28443123
140PRKD10.26085804
141CDC70.25730984
142FYN0.25481365
143MAP3K20.25080195
144RIPK10.24125228

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.00492753
2Fat digestion and absorption_Homo sapiens_hsa049754.11451668
3Vitamin digestion and absorption_Homo sapiens_hsa049773.17126841
4Renin-angiotensin system_Homo sapiens_hsa046143.11271753
5T cell receptor signaling pathway_Homo sapiens_hsa046602.94762759
6Mineral absorption_Homo sapiens_hsa049782.91835082
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.82406859
8Carbohydrate digestion and absorption_Homo sapiens_hsa049732.59571508
9Arginine biosynthesis_Homo sapiens_hsa002202.58383451
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.56011395
11Antigen processing and presentation_Homo sapiens_hsa046122.36048719
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.23698879
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23669020
14Retinol metabolism_Homo sapiens_hsa008302.22969895
15Linoleic acid metabolism_Homo sapiens_hsa005912.10193166
16Chemical carcinogenesis_Homo sapiens_hsa052042.09563803
17Caffeine metabolism_Homo sapiens_hsa002322.03475142
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.97954255
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.97635802
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94087181
21Complement and coagulation cascades_Homo sapiens_hsa046101.91922603
22Hematopoietic cell lineage_Homo sapiens_hsa046401.83870075
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.80589178
24Galactose metabolism_Homo sapiens_hsa000521.79713879
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.78296335
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.72172227
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67362853
28Measles_Homo sapiens_hsa051621.66682812
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.65208979
30Fatty acid degradation_Homo sapiens_hsa000711.60912615
31Staphylococcus aureus infection_Homo sapiens_hsa051501.53899203
32B cell receptor signaling pathway_Homo sapiens_hsa046621.52774816
33Arachidonic acid metabolism_Homo sapiens_hsa005901.48141715
34Protein digestion and absorption_Homo sapiens_hsa049741.47714833
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.46272403
36Non-homologous end-joining_Homo sapiens_hsa034501.45518688
37Graft-versus-host disease_Homo sapiens_hsa053321.41476032
38Phenylalanine metabolism_Homo sapiens_hsa003601.35822917
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.35540796
40Osteoclast differentiation_Homo sapiens_hsa043801.33332703
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30456130
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.29633805
43Tryptophan metabolism_Homo sapiens_hsa003801.26536029
44Other glycan degradation_Homo sapiens_hsa005111.24854925
45Starch and sucrose metabolism_Homo sapiens_hsa005001.24219570
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.22764369
47Folate biosynthesis_Homo sapiens_hsa007901.16884325
48Leishmaniasis_Homo sapiens_hsa051401.15747432
49Apoptosis_Homo sapiens_hsa042101.15424019
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12521523
51Arginine and proline metabolism_Homo sapiens_hsa003301.09246728
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04964346
53Pancreatic cancer_Homo sapiens_hsa052121.03768227
54Herpes simplex infection_Homo sapiens_hsa051680.99449055
55Thyroid cancer_Homo sapiens_hsa052160.98777429
56Ether lipid metabolism_Homo sapiens_hsa005650.94811646
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93705606
58Influenza A_Homo sapiens_hsa051640.91812772
59Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91611106
60Toxoplasmosis_Homo sapiens_hsa051450.90316430
61Bile secretion_Homo sapiens_hsa049760.90251465
62Ribosome_Homo sapiens_hsa030100.89749184
63Pancreatic secretion_Homo sapiens_hsa049720.89662031
64Hepatitis C_Homo sapiens_hsa051600.89285012
65TNF signaling pathway_Homo sapiens_hsa046680.88786309
66Tyrosine metabolism_Homo sapiens_hsa003500.87478102
67Butanoate metabolism_Homo sapiens_hsa006500.87362498
68Hepatitis B_Homo sapiens_hsa051610.87089698
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85992320
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85978662
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84586603
72Pentose phosphate pathway_Homo sapiens_hsa000300.84468205
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82655815
74Fructose and mannose metabolism_Homo sapiens_hsa000510.82574457
75Asthma_Homo sapiens_hsa053100.81561041
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.80048597
77Type I diabetes mellitus_Homo sapiens_hsa049400.79805221
78Peroxisome_Homo sapiens_hsa041460.77755357
79Histidine metabolism_Homo sapiens_hsa003400.76756894
80Chemokine signaling pathway_Homo sapiens_hsa040620.73901002
81Acute myeloid leukemia_Homo sapiens_hsa052210.73517867
82Viral carcinogenesis_Homo sapiens_hsa052030.72556891
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71992819
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71063513
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70205528
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70173786
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69661731
88Glycerolipid metabolism_Homo sapiens_hsa005610.68894078
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65860255
90Chronic myeloid leukemia_Homo sapiens_hsa052200.64848506
91ABC transporters_Homo sapiens_hsa020100.64481861
92Viral myocarditis_Homo sapiens_hsa054160.64025829
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.63838338
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63632916
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62897623
96Inositol phosphate metabolism_Homo sapiens_hsa005620.62788011
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62492626
98Fatty acid metabolism_Homo sapiens_hsa012120.61419290
99Insulin resistance_Homo sapiens_hsa049310.58821737
100Platelet activation_Homo sapiens_hsa046110.58220058
101Shigellosis_Homo sapiens_hsa051310.58168518
102Fatty acid biosynthesis_Homo sapiens_hsa000610.57509017
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56986446
104Legionellosis_Homo sapiens_hsa051340.55866156
105PPAR signaling pathway_Homo sapiens_hsa033200.52790639
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52761539
107VEGF signaling pathway_Homo sapiens_hsa043700.52689784
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.50758073
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48855167
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48566767
111Pertussis_Homo sapiens_hsa051330.48503471
112Thyroid hormone synthesis_Homo sapiens_hsa049180.48376534
113Sphingolipid metabolism_Homo sapiens_hsa006000.48191030
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47991838
115Lysine degradation_Homo sapiens_hsa003100.47443183
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44842994
117Non-small cell lung cancer_Homo sapiens_hsa052230.44803498
118Glutathione metabolism_Homo sapiens_hsa004800.44040785
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41697772
120Colorectal cancer_Homo sapiens_hsa052100.40159448
121Salmonella infection_Homo sapiens_hsa051320.40082660
122Tuberculosis_Homo sapiens_hsa051520.39935656
123HTLV-I infection_Homo sapiens_hsa051660.39468615
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37931511
125Autoimmune thyroid disease_Homo sapiens_hsa053200.37727789
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37492184
127DNA replication_Homo sapiens_hsa030300.36916456
128Allograft rejection_Homo sapiens_hsa053300.36398963
129Prion diseases_Homo sapiens_hsa050200.36346841
130Adherens junction_Homo sapiens_hsa045200.35738297
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34984690
132African trypanosomiasis_Homo sapiens_hsa051430.34920243
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.34608491
134Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34302635
135Small cell lung cancer_Homo sapiens_hsa052220.33561388
136Sulfur metabolism_Homo sapiens_hsa009200.32946487
137Prolactin signaling pathway_Homo sapiens_hsa049170.31430593
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30704227
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30436928
140One carbon pool by folate_Homo sapiens_hsa006700.30236966
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.30071973
142Insulin secretion_Homo sapiens_hsa049110.25848934
143Glucagon signaling pathway_Homo sapiens_hsa049220.25474382
144Glycosaminoglycan degradation_Homo sapiens_hsa005310.24396117
145Metabolic pathways_Homo sapiens_hsa011000.21514981
146beta-Alanine metabolism_Homo sapiens_hsa004100.19552292
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17658631
148Renin secretion_Homo sapiens_hsa049240.16329020
149Carbon metabolism_Homo sapiens_hsa012000.15739749
150Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15253705
151Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15080507
152Biosynthesis of amino acids_Homo sapiens_hsa012300.14425011
153Type II diabetes mellitus_Homo sapiens_hsa049300.06657470

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