UNC5D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)6.09757047
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.95243822
3regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.75941572
4vocalization behavior (GO:0071625)5.71001366
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.67399723
6regulation of glutamate receptor signaling pathway (GO:1900449)5.49755917
7presynaptic membrane assembly (GO:0097105)5.43857296
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.42999769
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.30299993
10protein localization to synapse (GO:0035418)5.27740828
11synaptic vesicle exocytosis (GO:0016079)5.23153463
12postsynaptic membrane organization (GO:0001941)5.08875604
13neurotransmitter-gated ion channel clustering (GO:0072578)5.06406102
14glutamate secretion (GO:0014047)5.05146320
15regulation of synaptic vesicle exocytosis (GO:2000300)4.99026191
16presynaptic membrane organization (GO:0097090)4.87793195
17pyrimidine nucleobase catabolic process (GO:0006208)4.71657122
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.59614791
19locomotory exploration behavior (GO:0035641)4.56708427
20synaptic vesicle maturation (GO:0016188)4.56653656
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.54304608
22negative regulation of synaptic transmission, GABAergic (GO:0032229)4.48027239
23regulation of synaptic vesicle transport (GO:1902803)4.34890812
24neurotransmitter secretion (GO:0007269)4.29991240
25glutamate receptor signaling pathway (GO:0007215)4.29086043
26neuron recognition (GO:0008038)4.24703871
27synaptic transmission, glutamatergic (GO:0035249)4.18843669
28neuron-neuron synaptic transmission (GO:0007270)4.13479900
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.10148627
30gamma-aminobutyric acid signaling pathway (GO:0007214)4.04014828
31exploration behavior (GO:0035640)3.97814914
32regulation of gene silencing by RNA (GO:0060966)3.95414924
33regulation of posttranscriptional gene silencing (GO:0060147)3.95414924
34regulation of gene silencing by miRNA (GO:0060964)3.95414924
35positive regulation of synaptic transmission, GABAergic (GO:0032230)3.94316875
36startle response (GO:0001964)3.91913765
37regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.90837149
38axonal fasciculation (GO:0007413)3.90553724
39response to histamine (GO:0034776)3.86746254
40cerebellar granule cell differentiation (GO:0021707)3.82654731
41neuronal action potential propagation (GO:0019227)3.82383059
42nucleobase catabolic process (GO:0046113)3.82134855
43regulation of postsynaptic membrane potential (GO:0060078)3.77031906
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.74544743
45positive regulation of synapse assembly (GO:0051965)3.70372011
46dendritic spine morphogenesis (GO:0060997)3.69038740
47gamma-aminobutyric acid transport (GO:0015812)3.68676423
48positive regulation of membrane potential (GO:0045838)3.66321299
49positive regulation of neurotransmitter secretion (GO:0001956)3.64406305
50proline transport (GO:0015824)3.62992579
51regulation of long-term neuronal synaptic plasticity (GO:0048169)3.62207650
52layer formation in cerebral cortex (GO:0021819)3.59831962
53neurotransmitter transport (GO:0006836)3.58701887
54positive regulation of dendritic spine morphogenesis (GO:0061003)3.56607950
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.54281852
56regulation of synaptic transmission, glutamatergic (GO:0051966)3.54159617
57regulation of neuronal synaptic plasticity (GO:0048168)3.51274082
58regulation of neurotransmitter secretion (GO:0046928)3.50104890
59auditory behavior (GO:0031223)3.48628489
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.48389792
61positive regulation of synapse maturation (GO:0090129)3.44029195
62regulation of respiratory system process (GO:0044065)3.43964171
63response to auditory stimulus (GO:0010996)3.42892538
64cerebellar Purkinje cell differentiation (GO:0021702)3.41706948
65synapse assembly (GO:0007416)3.39189182
66long-term memory (GO:0007616)3.37611268
67regulation of synapse assembly (GO:0051963)3.33343667
68transmission of nerve impulse (GO:0019226)3.31433468
69positive regulation of neurotransmitter transport (GO:0051590)3.31026948
70kidney morphogenesis (GO:0060993)3.28374115
71atrial cardiac muscle cell action potential (GO:0086014)3.28209122
72mechanosensory behavior (GO:0007638)3.27777135
73negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.27163694
74negative regulation of translation, ncRNA-mediated (GO:0040033)3.27163694
75regulation of translation, ncRNA-mediated (GO:0045974)3.27163694
76regulation of neurotransmitter levels (GO:0001505)3.27110695
77long-term synaptic potentiation (GO:0060291)3.24234861
78membrane hyperpolarization (GO:0060081)3.23059444
79regulation of synaptic transmission, GABAergic (GO:0032228)3.20602179
80regulation of neurotransmitter transport (GO:0051588)3.20306743
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15175126
82regulation of vesicle fusion (GO:0031338)3.14628028
83regulation of synapse structural plasticity (GO:0051823)3.10902953
84pre-miRNA processing (GO:0031054)3.10068904
85regulation of synapse maturation (GO:0090128)3.10025801
86righting reflex (GO:0060013)3.08444469
87membrane depolarization (GO:0051899)3.08219772
88negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07308175
89regulation of telomere maintenance via telomerase (GO:0032210)3.07146459
90regulation of dendritic spine morphogenesis (GO:0061001)3.06861593
91regulation of synaptic plasticity (GO:0048167)3.06672748
92cerebral cortex radially oriented cell migration (GO:0021799)3.04977022
93short-term memory (GO:0007614)3.03792716
94regulation of respiratory gaseous exchange (GO:0043576)3.03069176
95synaptic vesicle endocytosis (GO:0048488)3.02906759
96negative regulation of DNA-dependent DNA replication (GO:2000104)3.02237812
97positive regulation of synaptic transmission (GO:0050806)2.98576275
98opioid receptor signaling pathway (GO:0038003)2.97443047
99central nervous system projection neuron axonogenesis (GO:0021952)2.95999468
100regulation of dendritic spine development (GO:0060998)2.95606608
101synaptic transmission (GO:0007268)2.93602434
102social behavior (GO:0035176)2.92933114
103intraspecies interaction between organisms (GO:0051703)2.92933114
104learning (GO:0007612)2.92468122
105positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91715409
106regulation of synapse organization (GO:0050807)2.91327615
107behavioral defense response (GO:0002209)2.90237601
108behavioral fear response (GO:0001662)2.90237601
109innervation (GO:0060384)2.87924367
110cochlea development (GO:0090102)2.86907243
111dendrite morphogenesis (GO:0048813)2.86115466
112dendrite development (GO:0016358)2.85482520
113synapse organization (GO:0050808)2.85050481
114negative regulation of dendrite morphogenesis (GO:0050774)2.84765797
115membrane depolarization during action potential (GO:0086010)2.84758941
116regulation of nuclear cell cycle DNA replication (GO:0033262)2.76983549
117regulation of mitotic spindle checkpoint (GO:1903504)2.73106965
118regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.73106965
119regulation of feeding behavior (GO:0060259)2.72429698
120regulation of cell fate specification (GO:0042659)2.70955726
121regulation of mesoderm development (GO:2000380)2.70881946
122limb bud formation (GO:0060174)2.70166378
123establishment of integrated proviral latency (GO:0075713)2.65629899
124DNA double-strand break processing (GO:0000729)2.63714278
125negative regulation of dendrite development (GO:2000171)2.63431997
126regulation of telomere maintenance (GO:0032204)2.63037861
127regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.57445453
128dorsal/ventral axis specification (GO:0009950)2.51908106
129cell fate commitment involved in formation of primary germ layer (GO:0060795)2.48584757
130chromatin remodeling at centromere (GO:0031055)2.48394124
131inner ear receptor cell development (GO:0060119)2.46602189
132fear response (GO:0042596)2.43486134
133regulation of growth hormone secretion (GO:0060123)2.42979942
134negative regulation of catecholamine secretion (GO:0033604)2.42480278
135serotonin receptor signaling pathway (GO:0007210)2.39620017
136replication fork processing (GO:0031297)2.38972502
137histone exchange (GO:0043486)2.38677131
138lung-associated mesenchyme development (GO:0060484)2.35564570
139negative regulation of DNA recombination (GO:0045910)2.34819114
140regulation of centriole replication (GO:0046599)2.32452621
141CENP-A containing nucleosome assembly (GO:0034080)2.32147238
142olfactory bulb development (GO:0021772)2.31556984
143positive regulation of growth hormone secretion (GO:0060124)2.30590209
144otic vesicle formation (GO:0030916)2.29554839
145C4-dicarboxylate transport (GO:0015740)2.29260824
146paraxial mesoderm development (GO:0048339)2.28518494
147cell migration in hindbrain (GO:0021535)2.27574699
148regulation of helicase activity (GO:0051095)2.26681272
149mitotic sister chromatid cohesion (GO:0007064)2.25988832
150regulation of hexokinase activity (GO:1903299)2.24874212
151regulation of glucokinase activity (GO:0033131)2.24874212
152DNA replication-dependent nucleosome assembly (GO:0006335)2.22857976
153DNA replication-dependent nucleosome organization (GO:0034723)2.22857976
154chemosensory behavior (GO:0007635)2.21133854
155regulation of non-canonical Wnt signaling pathway (GO:2000050)2.21007370
156maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.19386355
157regulation of cell fate commitment (GO:0010453)2.18467638
158single strand break repair (GO:0000012)2.17401133
159L-serine metabolic process (GO:0006563)2.17324384
160cAMP-mediated signaling (GO:0019933)2.15341911
161DNA replication checkpoint (GO:0000076)2.14960685
162DNA damage response, detection of DNA damage (GO:0042769)2.14918015

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.72109894
2GBX2_23144817_ChIP-Seq_PC3_Human4.49584924
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.02662978
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96287729
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93082490
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.83337648
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78740879
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.59909232
9TAF15_26573619_Chip-Seq_HEK293_Human2.51838819
10* REST_21632747_ChIP-Seq_MESCs_Mouse2.48173518
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46934805
12* GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46847451
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42689853
14* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41311665
15* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41311665
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37873460
17* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.35252995
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35194936
19* EED_16625203_ChIP-ChIP_MESCs_Mouse2.34371037
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31093309
21* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22915957
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16561918
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15866159
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15145160
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12551088
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03660752
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03102025
28DROSHA_22980978_ChIP-Seq_HELA_Human2.03028289
29POU5F1_16153702_ChIP-ChIP_HESCs_Human2.02993341
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.01501949
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.01419461
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99660321
33* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99420526
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97729922
35AR_21572438_ChIP-Seq_LNCaP_Human1.95121412
36* P300_19829295_ChIP-Seq_ESCs_Human1.89993814
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89441421
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.86795098
39* REST_18959480_ChIP-ChIP_MESCs_Mouse1.85559040
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.85162422
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85024161
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74981413
43* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74066815
44* RARB_27405468_Chip-Seq_BRAIN_Mouse1.73062109
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68469250
46FUS_26573619_Chip-Seq_HEK293_Human1.67664065
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.66971995
48E2F7_22180533_ChIP-Seq_HELA_Human1.64326359
49RNF2_27304074_Chip-Seq_NSC_Mouse1.63689293
50IGF1R_20145208_ChIP-Seq_DFB_Human1.57156546
51* SMAD3_21741376_ChIP-Seq_EPCs_Human1.56857335
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56693903
53* PIAS1_25552417_ChIP-Seq_VCAP_Human1.49572596
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49539148
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.48384171
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47881973
57* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45393367
58* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45222326
59ZNF274_21170338_ChIP-Seq_K562_Hela1.45166751
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45112416
61VDR_22108803_ChIP-Seq_LS180_Human1.45069930
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44346966
63* AR_25329375_ChIP-Seq_VCAP_Human1.39627301
64* STAT3_23295773_ChIP-Seq_U87_Human1.36879671
65* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36767881
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.34901730
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34393511
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33005804
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31182411
70CBP_20019798_ChIP-Seq_JUKART_Human1.31182411
71* NANOG_16153702_ChIP-ChIP_HESCs_Human1.30260805
72ER_23166858_ChIP-Seq_MCF-7_Human1.29851978
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.27884283
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26632821
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.25827983
76* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25369010
77* TCF4_23295773_ChIP-Seq_U87_Human1.25104458
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23454369
79* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23141914
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23091924
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.22804997
82* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22610263
83* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22534709
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21357603
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.20573450
86KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.18897554
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18327589
88TBX3_20139965_ChIP-Seq_ESCs_Mouse1.18299969
89TBX3_20139965_ChIP-Seq_MESCs_Mouse1.18211646
90* RUNX2_22187159_ChIP-Seq_PCA_Human1.17853109
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17634834
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16998262
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.15220276
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15146208
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14626814
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14626814
97POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.14363922
98JUN_21703547_ChIP-Seq_K562_Human1.14061009
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13409432
100EWS_26573619_Chip-Seq_HEK293_Human1.13291625
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13285250
102AR_19668381_ChIP-Seq_PC3_Human1.12485429
103* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11908753
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11683292
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.11506275
106* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11074435
107* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10616654
108AHR_22903824_ChIP-Seq_MCF-7_Human1.10600924
109FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10365361
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09740243
111ERG_21242973_ChIP-ChIP_JURKAT_Human1.09460554
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08613625
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08341759
114FLI1_27457419_Chip-Seq_LIVER_Mouse1.07779593
115* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07314509
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07207863
117* TP53_18474530_ChIP-ChIP_U2OS_Human1.06349625
118ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06340386
119IRF1_19129219_ChIP-ChIP_H3396_Human1.05559870
120PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05451763
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05353131
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.05076807
123BCAT_22108803_ChIP-Seq_LS180_Human1.04918352
124* SMAD3_21741376_ChIP-Seq_ESCs_Human1.04158737
125P53_22387025_ChIP-Seq_ESCs_Mouse1.02938525
126* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02827818
127* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02133328
128CMYC_18555785_Chip-Seq_ESCs_Mouse1.01694752
129* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00936326
130EZH2_27294783_Chip-Seq_NPCs_Mouse1.00008944
131CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99152410
132* KDM2B_26808549_Chip-Seq_REH_Human0.99099943
133TCF4_22108803_ChIP-Seq_LS180_Human0.98590238
134RING1B_27294783_Chip-Seq_NPCs_Mouse0.97877248
135SOX2_19829295_ChIP-Seq_ESCs_Human0.96626599
136NANOG_19829295_ChIP-Seq_ESCs_Human0.96626599
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95706335
138SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95333675
139SOX9_26525672_Chip-Seq_HEART_Mouse0.94826041
140SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94463238

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.53779429
2MP0004859_abnormal_synaptic_plasticity4.95152304
3MP0003635_abnormal_synaptic_transmissio3.68978553
4MP0001968_abnormal_touch/_nociception3.53592598
5MP0003890_abnormal_embryonic-extraembry3.26156771
6MP0009745_abnormal_behavioral_response3.26040146
7MP0009046_muscle_twitch3.21714517
8MP0002064_seizures2.97428845
9MP0004270_analgesia2.97387483
10MP0002063_abnormal_learning/memory/cond2.97217780
11MP0005423_abnormal_somatic_nervous2.87834098
12MP0002736_abnormal_nociception_after2.83782583
13MP0002572_abnormal_emotion/affect_behav2.79625390
14MP0002734_abnormal_mechanical_nocicepti2.63226828
15MP0001486_abnormal_startle_reflex2.49900598
16MP0002735_abnormal_chemical_nociception2.49880406
17MP0006276_abnormal_autonomic_nervous2.48070472
18MP0005645_abnormal_hypothalamus_physiol2.43582635
19MP0002272_abnormal_nervous_system2.42905247
20MP0003122_maternal_imprinting2.39350568
21MP0001440_abnormal_grooming_behavior2.34697120
22MP0001501_abnormal_sleep_pattern2.29241603
23MP0005646_abnormal_pituitary_gland2.22976905
24MP0002067_abnormal_sensory_capabilities2.10357762
25MP0001188_hyperpigmentation2.06346176
26MP0003941_abnormal_skin_development1.99070595
27MP0003787_abnormal_imprinting1.98467163
28MP0003119_abnormal_digestive_system1.96492289
29MP0002254_reproductive_system_inflammat1.95929118
30MP0002184_abnormal_innervation1.92864008
31MP0002557_abnormal_social/conspecific_i1.92233308
32MP0000778_abnormal_nervous_system1.92036615
33MP0009780_abnormal_chondrocyte_physiolo1.90112516
34MP0004924_abnormal_behavior1.85271862
35MP0005386_behavior/neurological_phenoty1.85271862
36MP0001970_abnormal_pain_threshold1.82565635
37MP0002733_abnormal_thermal_nociception1.82291344
38MP0003879_abnormal_hair_cell1.80568002
39MP0001984_abnormal_olfaction1.73167009
40MP0001529_abnormal_vocalization1.72562293
41MP0003136_yellow_coat_color1.68296688
42MP0000566_synostosis1.67999972
43MP0001293_anophthalmia1.66369148
44MP0002938_white_spotting1.63666736
45MP0003937_abnormal_limbs/digits/tail_de1.63088627
46MP0004133_heterotaxia1.59382432
47MP0004142_abnormal_muscle_tone1.49567101
48MP0000516_abnormal_urinary_system1.46406758
49MP0005367_renal/urinary_system_phenotyp1.46406758
50MP0003567_abnormal_fetal_cardiomyocyte1.46383753
51MP0004858_abnormal_nervous_system1.45798274
52MP0001502_abnormal_circadian_rhythm1.44748115
53MP0004811_abnormal_neuron_physiology1.44132757
54MP0002233_abnormal_nose_morphology1.43229769
55MP0000537_abnormal_urethra_morphology1.42373312
56MP0008569_lethality_at_weaning1.40071600
57MP0000049_abnormal_middle_ear1.39773101
58MP0004742_abnormal_vestibular_system1.38969626
59MP0008058_abnormal_DNA_repair1.38403826
60MP0009672_abnormal_birth_weight1.37420276
61MP0000955_abnormal_spinal_cord1.35419286
62MP0002882_abnormal_neuron_morphology1.32049021
63MP0003121_genomic_imprinting1.31366388
64MP0002876_abnormal_thyroid_physiology1.29895677
65MP0002066_abnormal_motor_capabilities/c1.27555453
66MP0001299_abnormal_eye_distance/1.25639583
67MP0001905_abnormal_dopamine_level1.22773249
68MP0005551_abnormal_eye_electrophysiolog1.18895217
69MP0000631_abnormal_neuroendocrine_gland1.14690703
70MP0003693_abnormal_embryo_hatching1.14464863
71MP0003718_maternal_effect1.10067623
72MP0005171_absent_coat_pigmentation1.08705329
73MP0010030_abnormal_orbit_morphology1.07971872
74MP0004885_abnormal_endolymph1.04710544
75MP0008789_abnormal_olfactory_epithelium1.04262158
76MP0004957_abnormal_blastocyst_morpholog1.03651819
77MP0001963_abnormal_hearing_physiology1.03134832
78MP0002697_abnormal_eye_size1.02018699
79MP0002152_abnormal_brain_morphology1.01553887
80MP0002822_catalepsy0.99868099
81MP0010386_abnormal_urinary_bladder0.97952873
82MP0009703_decreased_birth_body0.97760054
83MP0003938_abnormal_ear_development0.97641900
84MP0003123_paternal_imprinting0.97473664
85MP0003633_abnormal_nervous_system0.96118112
86MP0008932_abnormal_embryonic_tissue0.95165703
87MP0002084_abnormal_developmental_patter0.94734280
88MP0000579_abnormal_nail_morphology0.93557145
89MP0008872_abnormal_physiological_respon0.92974744
90MP0002234_abnormal_pharynx_morphology0.92606650
91MP0001286_abnormal_eye_development0.91746918
92MP0008004_abnormal_stomach_pH0.90004024
93MP0010352_gastrointestinal_tract_polyps0.88944651
94MP0003755_abnormal_palate_morphology0.86293165
95MP0005409_darkened_coat_color0.85607615
96MP0002638_abnormal_pupillary_reflex0.84376902
97MP0010094_abnormal_chromosome_stability0.84105927
98MP0002069_abnormal_eating/drinking_beha0.84076688
99MP0002102_abnormal_ear_morphology0.83926701
100MP0002752_abnormal_somatic_nervous0.83408529
101MP0002909_abnormal_adrenal_gland0.83016552
102MP0002229_neurodegeneration0.82994778
103MP0002090_abnormal_vision0.82306833
104MP0000026_abnormal_inner_ear0.82002795
105MP0006292_abnormal_olfactory_placode0.81661058
106MP0001177_atelectasis0.81597157
107MP0004085_abnormal_heartbeat0.81490942
108MP0003631_nervous_system_phenotype0.81489478
109MP0000569_abnormal_digit_pigmentation0.81067894
110MP0003329_amyloid_beta_deposits0.80885950
111MP0001986_abnormal_taste_sensitivity0.80221644
112MP0002085_abnormal_embryonic_tissue0.80022040
113MP0002111_abnormal_tail_morphology0.79661729
114MP0004145_abnormal_muscle_electrophysio0.79203040
115MP0001485_abnormal_pinna_reflex0.77814152
116MP0001664_abnormal_digestion0.76932183
117MP0004484_altered_response_of0.76554948
118MP0002653_abnormal_ependyma_morphology0.76082040
119MP0002081_perinatal_lethality0.74814980
120MP0003195_calcinosis0.74006067
121MP0003111_abnormal_nucleus_morphology0.73878949
122MP0000751_myopathy0.71872952
123MP0005394_taste/olfaction_phenotype0.71798893
124MP0005499_abnormal_olfactory_system0.71798893
125MP0003646_muscle_fatigue0.71639321
126MP0002751_abnormal_autonomic_nervous0.71263111
127MP0008877_abnormal_DNA_methylation0.71151996
128MP0001943_abnormal_respiration0.67162650
129MP0006072_abnormal_retinal_apoptosis0.66592048
130MP0005253_abnormal_eye_physiology0.65401400
131MP0005535_abnormal_body_temperature0.65146552
132MP0002837_dystrophic_cardiac_calcinosis0.64762159
133MP0002163_abnormal_gland_morphology0.63508491
134MP0003283_abnormal_digestive_organ0.63011189
135MP0008874_decreased_physiological_sensi0.62926025
136MP0004215_abnormal_myocardial_fiber0.62616786
137MP0003861_abnormal_nervous_system0.57374311
138MP0010770_preweaning_lethality0.56600717
139MP0002082_postnatal_lethality0.56600717
140MP0010769_abnormal_survival0.54293184
141MP0004233_abnormal_muscle_weight0.51902280
142MP0010768_mortality/aging0.51610957

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.88931605
2Epileptic encephalopathy (HP:0200134)5.96390470
3Atonic seizures (HP:0010819)5.28328104
4Focal seizures (HP:0007359)5.26211038
5Febrile seizures (HP:0002373)5.20904913
6Hyperventilation (HP:0002883)5.12338050
7Broad-based gait (HP:0002136)4.48993004
8Absence seizures (HP:0002121)4.43623127
9Myokymia (HP:0002411)4.28532291
10Progressive cerebellar ataxia (HP:0002073)4.13877705
11Dialeptic seizures (HP:0011146)4.07364551
12Visual hallucinations (HP:0002367)4.05331234
13Generalized tonic-clonic seizures (HP:0002069)3.80436752
14Colon cancer (HP:0003003)3.72606372
15Hepatoblastoma (HP:0002884)3.42318225
16Protruding tongue (HP:0010808)3.41581727
17Drooling (HP:0002307)3.37630549
18Excessive salivation (HP:0003781)3.37630549
19Hypoglycemic seizures (HP:0002173)3.27444757
20Gaze-evoked nystagmus (HP:0000640)3.21225760
21Poor eye contact (HP:0000817)3.09224125
22Septo-optic dysplasia (HP:0100842)3.02653625
23Fetal akinesia sequence (HP:0001989)3.00156898
24Polyphagia (HP:0002591)2.99753035
25Hyperinsulinemic hypoglycemia (HP:0000825)2.96724566
26Aqueductal stenosis (HP:0002410)2.94624434
27Inability to walk (HP:0002540)2.92571500
28Neoplasm of the adrenal cortex (HP:0100641)2.89842842
29Abnormal hair whorl (HP:0010721)2.89541811
30Absent speech (HP:0001344)2.88683313
31Abnormal eating behavior (HP:0100738)2.86156280
32Blue irides (HP:0000635)2.84921752
33Absent/shortened dynein arms (HP:0200106)2.77290990
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.77290990
35Progressive inability to walk (HP:0002505)2.75936912
36Urinary bladder sphincter dysfunction (HP:0002839)2.70196060
37Epileptiform EEG discharges (HP:0011182)2.67419981
38Truncal ataxia (HP:0002078)2.66332578
39Gait imbalance (HP:0002141)2.65820781
40Impaired vibration sensation in the lower limbs (HP:0002166)2.58481627
41Impaired social interactions (HP:0000735)2.58133504
42Abnormal social behavior (HP:0012433)2.58133504
43Dysdiadochokinesis (HP:0002075)2.55557844
44Ependymoma (HP:0002888)2.54817542
45Hyperglycinemia (HP:0002154)2.53638456
46Limb dystonia (HP:0002451)2.50684331
47Genetic anticipation (HP:0003743)2.47605023
48Amblyopia (HP:0000646)2.47559071
49EEG with generalized epileptiform discharges (HP:0011198)2.47431433
50Abnormality of the pancreatic islet cells (HP:0006476)2.45170646
51Abnormality of endocrine pancreas physiology (HP:0012093)2.45170646
52Hyperthyroidism (HP:0000836)2.45100372
53Abnormal ciliary motility (HP:0012262)2.42610684
54Cortical dysplasia (HP:0002539)2.40269765
55Vitreoretinal degeneration (HP:0000655)2.39731155
56Astrocytoma (HP:0009592)2.38894738
57Abnormality of the astrocytes (HP:0100707)2.38894738
58Optic nerve hypoplasia (HP:0000609)2.37515120
59Intestinal atresia (HP:0011100)2.36914613
60Abnormality of the labia minora (HP:0012880)2.36094747
61Glioma (HP:0009733)2.34223284
62Volvulus (HP:0002580)2.32695822
63Mutism (HP:0002300)2.32189946
64Anxiety (HP:0000739)2.29845395
65Fair hair (HP:0002286)2.29201139
66Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.28629729
67Bifid tongue (HP:0010297)2.27816077
68Abnormality of the corticospinal tract (HP:0002492)2.26199779
69Abnormality of salivation (HP:0100755)2.25885535
70Generalized hypopigmentation of hair (HP:0011358)2.24588977
71Hypsarrhythmia (HP:0002521)2.24198768
72Ankle clonus (HP:0011448)2.23547561
73Medial flaring of the eyebrow (HP:0010747)2.21303713
74Depression (HP:0000716)2.20523920
75Agitation (HP:0000713)2.19666873
76Failure to thrive in infancy (HP:0001531)2.19308523
77Action tremor (HP:0002345)2.18937911
78Cutaneous finger syndactyly (HP:0010554)2.16953295
79Congenital primary aphakia (HP:0007707)2.15821001
80Renal hypoplasia (HP:0000089)2.15758290
81Impaired smooth pursuit (HP:0007772)2.14163357
82Dysmetria (HP:0001310)2.13953024
83Nephrogenic diabetes insipidus (HP:0009806)2.12174814
84Abnormality of the metopic suture (HP:0005556)2.11647666
85Stereotypic behavior (HP:0000733)2.10761687
86Poor suck (HP:0002033)2.09510207
87Embryonal renal neoplasm (HP:0011794)2.09402265
88Pancreatic islet-cell hyperplasia (HP:0004510)2.08626250
89Cutaneous syndactyly (HP:0012725)2.08021811
90Specific learning disability (HP:0001328)2.07684251
91Abnormal respiratory epithelium morphology (HP:0012253)2.06665237
92Abnormal respiratory motile cilium morphology (HP:0005938)2.06665237
93Hemiparesis (HP:0001269)2.06467646
94Aplasia/Hypoplasia of the sternum (HP:0006714)2.03979483
95Abnormal respiratory motile cilium physiology (HP:0012261)2.03856544
96Akinesia (HP:0002304)2.03772907
97Generalized myoclonic seizures (HP:0002123)2.03414335
98Hypoglycemic coma (HP:0001325)2.02397181
99Pheochromocytoma (HP:0002666)2.02295619
100Neoplasm of the adrenal gland (HP:0100631)2.02196566
101Status epilepticus (HP:0002133)2.01502491
102Exotropia (HP:0000577)2.01307213
103Hypoventilation (HP:0002791)2.00869348
104Prominent metopic ridge (HP:0005487)2.00545813
105Papilledema (HP:0001085)2.00289286
106Breast carcinoma (HP:0003002)2.00125574
107Absent septum pellucidum (HP:0001331)1.99912583
108Sleep apnea (HP:0010535)1.99821668
109Gastroesophageal reflux (HP:0002020)1.99431074
110Abnormal lung lobation (HP:0002101)1.99424340
111Inappropriate behavior (HP:0000719)1.99403813
112Narrow nasal bridge (HP:0000446)1.99232129
113Shoulder girdle muscle weakness (HP:0003547)1.99083692
114Widely spaced teeth (HP:0000687)1.98945251
115Urinary urgency (HP:0000012)1.98613620
116Nephroblastoma (Wilms tumor) (HP:0002667)1.98597282
117Scrotal hypoplasia (HP:0000046)1.98431885
118Abnormality of the septum pellucidum (HP:0007375)1.97589115
119Supranuclear gaze palsy (HP:0000605)1.97073738
120Postural instability (HP:0002172)1.93655823
121Absent eyebrow (HP:0002223)1.92648602
122Tubulointerstitial nephritis (HP:0001970)1.91948501
123Choanal stenosis (HP:0000452)1.91791896
124Symptomatic seizures (HP:0011145)1.91738713
125Insidious onset (HP:0003587)1.90649116
126Termporal pattern (HP:0011008)1.90649116
127Spastic gait (HP:0002064)1.90446852
128Agnosia (HP:0010524)1.89213420
129Bilateral microphthalmos (HP:0007633)1.89031177
130Esotropia (HP:0000565)1.88329581
131Preaxial foot polydactyly (HP:0001841)1.87095596
132Stenosis of the external auditory canal (HP:0000402)1.85966458
133Broad foot (HP:0001769)1.84240503
134Labial hypoplasia (HP:0000066)1.83494821
135Abnormality of the hip-girdle musculature (HP:0001445)1.82990105
136Abnormality of the musculature of the pelvis (HP:0001469)1.82990105
137Abnormality of the ileum (HP:0001549)1.82262253
138Methylmalonic acidemia (HP:0002912)1.81439890
139Scanning speech (HP:0002168)1.80875408
140Meckel diverticulum (HP:0002245)1.80205486
141Neuroendocrine neoplasm (HP:0100634)1.80090362
142Rhabdomyosarcoma (HP:0002859)1.80010104
143Open mouth (HP:0000194)1.79535692
144Abnormality of binocular vision (HP:0011514)1.79450508
145Diplopia (HP:0000651)1.79450508
146Abnormality of ocular smooth pursuit (HP:0000617)1.77958736
147Gastrointestinal atresia (HP:0002589)1.77937459
148Bradykinesia (HP:0002067)1.76134297
149Myelomeningocele (HP:0002475)1.75860323
150Pendular nystagmus (HP:0012043)1.75822422
151Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75647027
152Degeneration of the lateral corticospinal tracts (HP:0002314)1.75647027
153Lower limb muscle weakness (HP:0007340)1.75355288
154Genital tract atresia (HP:0001827)1.75034533
155Medulloblastoma (HP:0002885)1.73798246
156Vaginal atresia (HP:0000148)1.72660525
157Hypoplastic female external genitalia (HP:0012815)1.72295761
158Incomplete penetrance (HP:0003829)1.72257652
159Papillary thyroid carcinoma (HP:0002895)1.70189009
160Neoplasm of the oral cavity (HP:0100649)1.69412896
161Restlessness (HP:0000711)1.68532900
162Supernumerary spleens (HP:0009799)1.68429818
163Abnormality of serum amino acid levels (HP:0003112)1.67682547
164Anophthalmia (HP:0000528)1.66406261
165Pancreatic fibrosis (HP:0100732)1.64615212
166Enlarged penis (HP:0000040)1.63545596
167Abdominal situs inversus (HP:0003363)1.63406072
168Abnormality of abdominal situs (HP:0011620)1.63406072
169Thyroid carcinoma (HP:0002890)1.63089913
170Micropenis (HP:0000054)1.62294990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM285.95749684
2CASK5.53054118
3NTRK34.12854249
4FRK3.66175710
5MARK13.59837195
6EPHA43.48353007
7MAP3K43.25963685
8MAP2K73.25159030
9FGFR22.90772729
10MAP3K122.73192154
11MAP3K92.62762340
12DAPK22.52567933
13MKNK22.18133789
14NTRK22.17320253
15TNIK2.12662283
16SIK22.08338082
17CCNB12.06699582
18MINK12.02825138
19MAP2K41.92416628
20STK38L1.91159614
21AKT31.89213277
22ZAK1.87963340
23MAPK131.85082822
24PLK21.78707989
25CDC71.77070391
26PLK31.68014307
27PRPF4B1.66591887
28CDK191.63779823
29MKNK11.62688212
30ACVR1B1.61771844
31SIK31.60812216
32PNCK1.59589467
33DAPK11.57003218
34PAK61.52558823
35SRPK11.50803533
36KSR11.42075895
37TTK1.39811025
38MAP4K21.30802009
39CDK51.25125183
40SGK21.22190473
41NUAK11.17153389
42PRKCG1.15635317
43CAMK2A1.13824248
44CSNK1G11.13735667
45SGK2231.06004965
46SGK4941.06004965
47GRK71.02306810
48CAMKK11.01184628
49TAF11.00091347
50OXSR10.99258127
51CAMKK20.97588770
52VRK10.93012624
53GRK50.92786508
54TNK20.91674586
55NLK0.90766126
56UHMK10.88190931
57CSNK1G20.85413467
58PLK40.85239379
59CAMK10.85133878
60NTRK10.83507149
61MAP3K100.82832481
62RIPK40.82313408
63PINK10.81710428
64WNK30.81222963
65LATS20.79216157
66FES0.78865064
67LATS10.77210728
68FGFR10.76711138
69PBK0.76349561
70BCR0.75218914
71PLK10.74518646
72SGK10.74022379
73CDK30.73988414
74PHKG20.73943592
75PHKG10.73943592
76PASK0.73904783
77SGK30.72754954
78KSR20.71503757
79BUB10.69888852
80ADRBK20.69798640
81RPS6KA40.68804268
82CDK180.68588574
83STK30.68337140
84PRKCE0.67309653
85TYRO30.66578236
86PAK30.66440333
87STK110.65220114
88CAMK2B0.64364514
89DYRK30.64141816
90CDK150.62690996
91CDK140.60448383
92STK380.58970716
93FLT30.58101653
94MAP3K60.58094796
95ERBB30.58009164
96BRSK20.57502183
97PRKCH0.56405401
98DYRK1A0.55099537
99ATM0.53758702
100CAMK1G0.53420777
101ALK0.53135280
102BMPR1B0.52522462
103MAPK120.52202894
104CAMK40.52009320
105CDK11A0.51943112
106INSRR0.51248477
107MAP3K20.50423231
108BRAF0.50232387
109NEK60.50100889
110MAPK70.49299592
111MARK20.49154477
112PRKD30.48106522
113ADRBK10.47382914
114RET0.47174519
115TIE10.46956391
116BMPR20.46524572
117CSNK1G30.46494487
118TGFBR10.45925822
119FGR0.45338547
120PKN10.45157461
121CSNK1E0.44623496
122WEE10.41635399
123VRK20.41584063
124PRKCZ0.41378038
125ERBB40.41025777
126GRK10.40799024
127NME10.39478969
128ATR0.38628633
129CAMK2D0.38506563
130PRKG10.38307828
131CHEK20.37539756
132EPHA30.37517531
133EIF2AK20.37326425
134RPS6KA20.37198683
135YES10.36986829
136PRKDC0.36860352
137TSSK60.36587124
138PIK3CA0.36316069
139RPS6KA30.36092591
140CAMK1D0.35655300
141MUSK0.34544137
142DYRK20.33966817
143PRKACA0.33492433
144CSNK1A1L0.33460176
145ARAF0.33285861
146CAMK2G0.32612585
147DAPK30.29575944
148PRKCB0.29377366
149WNK10.29171272
150CDK80.28900951

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.66871315
2Synaptic vesicle cycle_Homo sapiens_hsa047213.65848524
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.00061341
4GABAergic synapse_Homo sapiens_hsa047272.94127473
5Morphine addiction_Homo sapiens_hsa050322.79568648
6Circadian entrainment_Homo sapiens_hsa047132.62341263
7Olfactory transduction_Homo sapiens_hsa047402.56622896
8Glutamatergic synapse_Homo sapiens_hsa047242.53300510
9Long-term potentiation_Homo sapiens_hsa047202.38741509
10Amphetamine addiction_Homo sapiens_hsa050312.31373933
11Protein export_Homo sapiens_hsa030602.26439349
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.12347981
13Taste transduction_Homo sapiens_hsa047422.09913217
14Dopaminergic synapse_Homo sapiens_hsa047282.08501958
15Serotonergic synapse_Homo sapiens_hsa047262.07059681
16Collecting duct acid secretion_Homo sapiens_hsa049662.03798585
17Salivary secretion_Homo sapiens_hsa049702.00625309
18Insulin secretion_Homo sapiens_hsa049111.95496641
19Long-term depression_Homo sapiens_hsa047301.88147283
20Renin secretion_Homo sapiens_hsa049241.82280603
21Non-homologous end-joining_Homo sapiens_hsa034501.81686079
22Cholinergic synapse_Homo sapiens_hsa047251.75424718
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72861539
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67989743
25Cocaine addiction_Homo sapiens_hsa050301.66964364
26Propanoate metabolism_Homo sapiens_hsa006401.66244479
27Calcium signaling pathway_Homo sapiens_hsa040201.61986343
28Gastric acid secretion_Homo sapiens_hsa049711.61184744
29Oxytocin signaling pathway_Homo sapiens_hsa049211.57106712
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55441837
31Mismatch repair_Homo sapiens_hsa034301.53653594
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51433012
33Butanoate metabolism_Homo sapiens_hsa006501.50803516
34* Axon guidance_Homo sapiens_hsa043601.45103865
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.42786453
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39730031
37Phototransduction_Homo sapiens_hsa047441.38938411
38Steroid biosynthesis_Homo sapiens_hsa001001.36480772
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34925628
40Basal transcription factors_Homo sapiens_hsa030221.34268103
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34116258
42Homologous recombination_Homo sapiens_hsa034401.29145329
43Vibrio cholerae infection_Homo sapiens_hsa051101.27790362
44RNA degradation_Homo sapiens_hsa030181.27149315
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26827834
46GnRH signaling pathway_Homo sapiens_hsa049121.26112074
47Hippo signaling pathway_Homo sapiens_hsa043901.24826103
48RNA transport_Homo sapiens_hsa030131.24180024
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23624637
50Fanconi anemia pathway_Homo sapiens_hsa034601.22598867
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21731275
52Gap junction_Homo sapiens_hsa045401.21580620
53cAMP signaling pathway_Homo sapiens_hsa040241.19563139
54RNA polymerase_Homo sapiens_hsa030201.19061660
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18881291
56Selenocompound metabolism_Homo sapiens_hsa004501.17243172
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15342712
58Vitamin B6 metabolism_Homo sapiens_hsa007501.15307661
59Basal cell carcinoma_Homo sapiens_hsa052171.14978901
60ErbB signaling pathway_Homo sapiens_hsa040121.13371133
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11732506
62mRNA surveillance pathway_Homo sapiens_hsa030151.11341521
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10514219
64Type II diabetes mellitus_Homo sapiens_hsa049301.08503085
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05127088
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.04659087
67Melanogenesis_Homo sapiens_hsa049161.02732076
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00857419
69Estrogen signaling pathway_Homo sapiens_hsa049151.00416907
70beta-Alanine metabolism_Homo sapiens_hsa004100.99576380
71DNA replication_Homo sapiens_hsa030300.99249163
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98086353
73Cardiac muscle contraction_Homo sapiens_hsa042600.98003045
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95657510
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93637574
76Cell cycle_Homo sapiens_hsa041100.92290548
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89614121
78Glioma_Homo sapiens_hsa052140.86462092
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86437107
80Oxidative phosphorylation_Homo sapiens_hsa001900.85515771
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.85252107
82TGF-beta signaling pathway_Homo sapiens_hsa043500.83090093
83Proteasome_Homo sapiens_hsa030500.82871955
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82244881
85Tight junction_Homo sapiens_hsa045300.81508699
86MAPK signaling pathway_Homo sapiens_hsa040100.79629216
87Spliceosome_Homo sapiens_hsa030400.77730319
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76838900
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73736540
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73581420
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73514827
92Base excision repair_Homo sapiens_hsa034100.73186740
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72938914
94Type I diabetes mellitus_Homo sapiens_hsa049400.71588168
95Alzheimers disease_Homo sapiens_hsa050100.70099131
96Oocyte meiosis_Homo sapiens_hsa041140.69986848
97Dilated cardiomyopathy_Homo sapiens_hsa054140.69404386
98Circadian rhythm_Homo sapiens_hsa047100.68959989
99Choline metabolism in cancer_Homo sapiens_hsa052310.67379280
100Sulfur metabolism_Homo sapiens_hsa009200.65815948
101Ras signaling pathway_Homo sapiens_hsa040140.65496049
102Pyruvate metabolism_Homo sapiens_hsa006200.64184459
103Dorso-ventral axis formation_Homo sapiens_hsa043200.61583302
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.59989052
105Tryptophan metabolism_Homo sapiens_hsa003800.59836861
106Wnt signaling pathway_Homo sapiens_hsa043100.59520151
107Purine metabolism_Homo sapiens_hsa002300.59393525
108Rheumatoid arthritis_Homo sapiens_hsa053230.57553469
109Pancreatic secretion_Homo sapiens_hsa049720.56891637
110Ovarian steroidogenesis_Homo sapiens_hsa049130.55172645
111Fatty acid elongation_Homo sapiens_hsa000620.53631782
112Alcoholism_Homo sapiens_hsa050340.52744288
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51321215
114Adherens junction_Homo sapiens_hsa045200.50427943
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49778878
116Linoleic acid metabolism_Homo sapiens_hsa005910.49335706
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49294293
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49026564
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48883797
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48768904
121One carbon pool by folate_Homo sapiens_hsa006700.48732424
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48658783
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48183573
124Vitamin digestion and absorption_Homo sapiens_hsa049770.47891066
125Retinol metabolism_Homo sapiens_hsa008300.47075088
126Thyroid hormone synthesis_Homo sapiens_hsa049180.46762834
127Endometrial cancer_Homo sapiens_hsa052130.46735294
128Renal cell carcinoma_Homo sapiens_hsa052110.46117876
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45375188
130Rap1 signaling pathway_Homo sapiens_hsa040150.44257822
131Parkinsons disease_Homo sapiens_hsa050120.44058854
132Fatty acid metabolism_Homo sapiens_hsa012120.43929174
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.42644587
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42415711
135Phagosome_Homo sapiens_hsa041450.42008972
136Huntingtons disease_Homo sapiens_hsa050160.41747404
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40768942
138Melanoma_Homo sapiens_hsa052180.40394297
139Colorectal cancer_Homo sapiens_hsa052100.37220408
140Inositol phosphate metabolism_Homo sapiens_hsa005620.36636095
141African trypanosomiasis_Homo sapiens_hsa051430.36563472
142Glucagon signaling pathway_Homo sapiens_hsa049220.36218551
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.36199222
144Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32703738
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32593121
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32403149
147Hedgehog signaling pathway_Homo sapiens_hsa043400.31044146
148Ether lipid metabolism_Homo sapiens_hsa005650.28998869
149Insulin signaling pathway_Homo sapiens_hsa049100.28516158
150Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25073067
151Prion diseases_Homo sapiens_hsa050200.22805171
152Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22556296
153Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22365049
154Regulation of autophagy_Homo sapiens_hsa041400.22216837

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