UNC93B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interferon-beta biosynthetic process (GO:0045357)6.06353194
2positive regulation by symbiont of host defense response (GO:0052509)5.86823519
3modulation by symbiont of host defense response (GO:0052031)5.86823519
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.86823519
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.86823519
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.86823519
7modulation by symbiont of host immune response (GO:0052553)5.86823519
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.75645444
9antigen processing and presentation of endogenous antigen (GO:0019883)5.48920001
10macrophage activation involved in immune response (GO:0002281)5.18603087
11regulation of B cell receptor signaling pathway (GO:0050855)5.18570860
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.06793367
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.06793367
14neutrophil activation involved in immune response (GO:0002283)4.99424317
15positive regulation of B cell differentiation (GO:0045579)4.93235342
16positive regulation of interferon-alpha production (GO:0032727)4.86681621
17immunoglobulin mediated immune response (GO:0016064)4.86048167
18B cell receptor signaling pathway (GO:0050853)4.85915865
19positive regulation of gamma-delta T cell activation (GO:0046645)4.80708476
20respiratory burst (GO:0045730)4.60682240
21regulation of interferon-alpha production (GO:0032647)4.59275506
22response to peptidoglycan (GO:0032494)4.28867859
23regulation of B cell differentiation (GO:0045577)4.27384496
24detection of other organism (GO:0098543)4.23724234
25positive regulation of antigen processing and presentation (GO:0002579)4.19178876
26microglial cell activation (GO:0001774)4.15093293
27detection of bacterium (GO:0016045)4.12118817
28positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.08018928
29regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.06316317
30neutrophil activation (GO:0042119)3.86135649
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.78911365
32response to host immune response (GO:0052572)3.78911365
33granulocyte activation (GO:0036230)3.71924823
34macrophage activation (GO:0042116)3.71850178
35myeloid cell activation involved in immune response (GO:0002275)3.71015912
36negative regulation of granulocyte differentiation (GO:0030853)3.69378473
37detection of external biotic stimulus (GO:0098581)3.60469710
38regulation of antigen processing and presentation (GO:0002577)3.57789030
39cellular extravasation (GO:0045123)3.55319290
40positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.54295982
41defense response to protozoan (GO:0042832)3.53874332
42response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.50231436
43response to host (GO:0075136)3.50231436
44response to host defenses (GO:0052200)3.50231436
45B cell mediated immunity (GO:0019724)3.50144819
46cellular response to zinc ion (GO:0071294)3.49381834
47response to muramyl dipeptide (GO:0032495)3.48826346
48NIK/NF-kappaB signaling (GO:0038061)3.48316326
49positive regulation of interferon-beta production (GO:0032728)3.44899309
50negative regulation of phagocytosis (GO:0050765)3.44685261
51interferon-gamma-mediated signaling pathway (GO:0060333)3.41147894
52detection of molecule of bacterial origin (GO:0032490)3.40836356
53regulation of gamma-delta T cell differentiation (GO:0045586)3.29991202
54negative regulation of erythrocyte differentiation (GO:0045647)3.29186832
55regulation of mast cell degranulation (GO:0043304)3.28694955
56positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.25312447
57response to type I interferon (GO:0034340)3.24102468
58regulation of gamma-delta T cell activation (GO:0046643)3.24051780
59regulation of dendritic cell antigen processing and presentation (GO:0002604)3.23126682
60cellular response to type I interferon (GO:0071357)3.22601164
61type I interferon signaling pathway (GO:0060337)3.22601164
62detection of biotic stimulus (GO:0009595)3.21286340
63lipopolysaccharide-mediated signaling pathway (GO:0031663)3.20751165
64pinocytosis (GO:0006907)3.19600618
65negative regulation of B cell proliferation (GO:0030889)3.19541520
66I-kappaB phosphorylation (GO:0007252)3.19060283
67positive regulation of mast cell activation (GO:0033005)3.18472232
68regulation of interleukin-12 biosynthetic process (GO:0045075)3.16064761
69germinal center formation (GO:0002467)3.13538760
70neutrophil mediated immunity (GO:0002446)3.13240342
71regulation of mast cell activation (GO:0033003)3.12768770
72response to protozoan (GO:0001562)3.12718041
73mannose metabolic process (GO:0006013)3.09210908
74negative regulation of cytokine production involved in immune response (GO:0002719)3.08524385
75mature B cell differentiation (GO:0002335)3.05584695
76Arp2/3 complex-mediated actin nucleation (GO:0034314)3.05565777
77regulation of mast cell activation involved in immune response (GO:0033006)3.05373588
78positive regulation of type 2 immune response (GO:0002830)3.04937255
79regulation of T-helper 2 cell differentiation (GO:0045628)3.04682056
80positive regulation of mast cell activation involved in immune response (GO:0033008)3.01422463
81positive regulation of mast cell degranulation (GO:0043306)3.01422463
82T-helper 1 type immune response (GO:0042088)3.01280061
83regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.00807462
84negative regulation of lymphocyte mediated immunity (GO:0002707)3.00200209
85myeloid leukocyte activation (GO:0002274)2.99541704
86myeloid dendritic cell activation (GO:0001773)2.99512351
87negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.97755610
88regulation of tolerance induction (GO:0002643)2.96813313
89positive regulation of cellular amide metabolic process (GO:0034250)2.93801785
90negative regulation of cell killing (GO:0031342)2.91771142
91negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.91771142
92negative regulation of interleukin-6 production (GO:0032715)2.91610946
93regulation of interleukin-8 biosynthetic process (GO:0045414)2.91570641
94myeloid dendritic cell differentiation (GO:0043011)2.90974891
95negative regulation of leukocyte mediated immunity (GO:0002704)2.89900931
96regulation of type I interferon-mediated signaling pathway (GO:0060338)2.88999990
97negative regulation of interleukin-12 production (GO:0032695)2.83315353
98leukocyte mediated cytotoxicity (GO:0001909)2.81109163
99positive regulation of Cdc42 GTPase activity (GO:0043089)2.80778449
100regulation of type 2 immune response (GO:0002828)2.79977880
101hydrogen peroxide biosynthetic process (GO:0050665)2.79752111
102B cell homeostasis (GO:0001782)2.77462956
103regulation of interferon-gamma biosynthetic process (GO:0045072)2.76019219
104regulation of leukocyte degranulation (GO:0043300)2.75893935
105dendritic cell differentiation (GO:0097028)2.74990268
106regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.74550249
107T cell migration (GO:0072678)2.74501263
108cellular response to interferon-gamma (GO:0071346)2.74115461
109cellular response to interferon-beta (GO:0035458)2.73614207
110regulation of myeloid leukocyte mediated immunity (GO:0002886)2.72960720
111leukocyte aggregation (GO:0070486)2.72749448
112positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.72548198
113regulation of T cell tolerance induction (GO:0002664)2.71009208
114JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.70714684
115negative regulation of myeloid cell apoptotic process (GO:0033033)2.70573123
116tolerance induction (GO:0002507)2.70542192
117regulation of T-helper 1 cell differentiation (GO:0045625)2.70460082
118production of molecular mediator involved in inflammatory response (GO:0002532)2.70382218
119natural killer cell mediated cytotoxicity (GO:0042267)2.70237375
120natural killer cell mediated immunity (GO:0002228)2.70237375
121amino sugar catabolic process (GO:0046348)2.69963179
122glycosphingolipid catabolic process (GO:0046479)2.69956250
123positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.69752814
124regulation of interferon-beta production (GO:0032648)2.68821710
125negative regulation of innate immune response (GO:0045824)2.68339144
126positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.68298342
127mast cell activation (GO:0045576)2.67084924
128positive regulation of toll-like receptor signaling pathway (GO:0034123)2.67023611
129response to fungus (GO:0009620)2.66040116
130negative regulation of toll-like receptor signaling pathway (GO:0034122)2.65570200
131B cell proliferation (GO:0042100)2.65534644
132reactive oxygen species biosynthetic process (GO:1903409)2.65331124
133adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.65204394
134negative regulation of T cell mediated immunity (GO:0002710)2.65058103
135positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.63212497
136cellular response to thyroid hormone stimulus (GO:0097067)2.63165318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.30777576
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.82239254
3* IRF8_27001747_Chip-Seq_BMDM_Mouse4.21728050
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.94036526
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.86991926
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.82502412
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.63504998
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.39340335
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.26350445
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.20027561
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97940565
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.90246738
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.88462455
14* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.74261623
15* VDR_21846776_ChIP-Seq_THP-1_Human2.71192918
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.71142567
17SCL_19346495_ChIP-Seq_HPC-7_Human2.68175730
18* MYC_22102868_ChIP-Seq_BL_Human2.51763671
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.45216510
20* SPI1_23547873_ChIP-Seq_NB4_Human2.44839155
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.42326853
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29732795
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28428916
24* VDR_24763502_ChIP-Seq_THP-1_Human2.26776964
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19666726
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.14365758
27* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.09597333
28MAF_26560356_Chip-Seq_TH1_Human2.08221253
29MYB_26560356_Chip-Seq_TH2_Human2.06333144
30* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06143428
31RUNX_20019798_ChIP-Seq_JUKART_Human2.05674935
32* SPI1_23127762_ChIP-Seq_K562_Human2.02319154
33RUNX1_22412390_ChIP-Seq_EML_Mouse2.00992997
34GATA1_22025678_ChIP-Seq_K562_Human1.98105456
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.96900542
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.94892790
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.92532647
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.90259116
39MYB_26560356_Chip-Seq_TH1_Human1.85070898
40E2F7_22180533_ChIP-Seq_HELA_Human1.79395909
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71695264
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70244499
43TCF7_22412390_ChIP-Seq_EML_Mouse1.69637278
44* UTX_26944678_Chip-Seq_JUKART_Human1.68094806
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67795091
46PU_27001747_Chip-Seq_BMDM_Mouse1.64090708
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59194137
48* RACK7_27058665_Chip-Seq_MCF-7_Human1.58548217
49* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55619297
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54391285
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49919735
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47285810
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42853176
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41573505
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41464369
56* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35125222
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.34107081
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31304065
59* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30974926
60GATA3_27048872_Chip-Seq_THYMUS_Human1.30611977
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30040536
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29586774
63BCOR_27268052_Chip-Seq_Bcells_Human1.28262198
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27711897
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27034711
66VDR_24787735_ChIP-Seq_THP-1_Human1.26125786
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.23253970
68PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21767822
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21640051
70MAF_26560356_Chip-Seq_TH2_Human1.21377243
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20676958
72KDM2B_26808549_Chip-Seq_DND41_Human1.20607379
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19982884
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19287160
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.19138519
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19113998
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18007599
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17934193
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17663678
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.17650781
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16578229
82P68_20966046_ChIP-Seq_HELA_Human1.15961128
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14765014
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.12776634
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12392562
86* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10797945
87* KDM2B_26808549_Chip-Seq_JURKAT_Human1.10408382
88* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09091803
89* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08754737
90ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08424548
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07556534
92KDM2B_26808549_Chip-Seq_K562_Human1.07357288
93GATA3_26560356_Chip-Seq_TH2_Human1.07272015
94SMC4_20622854_ChIP-Seq_HELA_Human1.04750404
95PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02349583
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01381149
97* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01222820
98* LXR_22292898_ChIP-Seq_THP-1_Human0.97454501
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.97446482
100* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96667556
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95394457
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95318325
103ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94763794
104CTCF_26484167_Chip-Seq_Bcells_Mouse0.92750846
105SPI1_20517297_ChIP-Seq_HL60_Human0.92382335
106STAT1_20625510_ChIP-Seq_HELA_Human0.92317645
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92123883
108FOXM1_23109430_ChIP-Seq_U2OS_Human0.89970358
109SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89763380
110TFEB_21752829_ChIP-Seq_HELA_Human0.89650888
111GATA1_19941826_ChIP-Seq_K562_Human0.86996813
112GATA2_19941826_ChIP-Seq_K562_Human0.84144255
113RXR_22158963_ChIP-Seq_LIVER_Mouse0.84135988
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82422673
115HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80431495
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79334902
117BCL6_27268052_Chip-Seq_Bcells_Human0.79074606
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78093460
119NOTCH1_21737748_ChIP-Seq_TLL_Human0.76853611
120NCOR1_26117541_ChIP-Seq_K562_Human0.73086683
121ELF1_17652178_ChIP-ChIP_JURKAT_Human0.72563190
122EGR1_23403033_ChIP-Seq_LIVER_Mouse0.72438511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation4.69247717
2MP0003303_peritoneal_inflammation3.45903908
3MP0003436_decreased_susceptibility_to3.28864780
4MP0001790_abnormal_immune_system3.22276467
5MP0005387_immune_system_phenotype3.22276467
6MP0001800_abnormal_humoral_immune3.16789555
7MP0005058_abnormal_lysosome_morphology3.16369194
8MP0005000_abnormal_immune_tolerance3.03802383
9MP0000685_abnormal_immune_system2.98826306
10* MP0002419_abnormal_innate_immunity2.95764530
11* MP0002452_abnormal_antigen_presenting2.93123419
12MP0009785_altered_susceptibility_to2.80918880
13MP0002148_abnormal_hypersensitivity_rea2.72508409
14MP0005671_abnormal_response_to2.69912828
15* MP0005025_abnormal_response_to2.67050731
16MP0006082_CNS_inflammation2.65617542
17* MP0002723_abnormal_immune_serum2.59904679
18MP0003191_abnormal_cellular_cholesterol2.45780573
19* MP0002420_abnormal_adaptive_immunity2.44790022
20* MP0001819_abnormal_immune_cell2.43730510
21MP0003172_abnormal_lysosome_physiology2.37646576
22MP0005464_abnormal_platelet_physiology2.28626592
23MP0009840_abnormal_foam_cell2.11291919
24MP0005451_abnormal_body_composition2.06761797
25MP0000716_abnormal_immune_system1.97043939
26MP0003300_gastrointestinal_ulcer1.95813869
27MP0003724_increased_susceptibility_to1.95176867
28MP0002398_abnormal_bone_marrow1.94871537
29MP0004510_myositis1.93178410
30MP0000689_abnormal_spleen_morphology1.88951683
31MP0002405_respiratory_system_inflammati1.88641271
32MP0001845_abnormal_inflammatory_respons1.86708139
33MP0001853_heart_inflammation1.85015365
34MP0008260_abnormal_autophagy1.84850737
35MP0001533_abnormal_skeleton_physiology1.78855690
36MP0002166_altered_tumor_susceptibility1.78715338
37MP0002396_abnormal_hematopoietic_system1.69666763
38MP0003183_abnormal_peptide_metabolism1.67213845
39MP0004947_skin_inflammation1.64319305
40MP0002429_abnormal_blood_cell1.63258688
41MP0010155_abnormal_intestine_physiology1.62795554
42MP0002722_abnormal_immune_system1.60296333
43* MP0008469_abnormal_protein_level1.57907280
44MP0009278_abnormal_bone_marrow1.54603750
45MP0009333_abnormal_splenocyte_physiolog1.48139053
46MP0002006_tumorigenesis1.45816433
47MP0000465_gastrointestinal_hemorrhage1.45288611
48MP0000343_altered_response_to1.45044491
49MP0003075_altered_response_to1.44253598
50MP0005310_abnormal_salivary_gland1.43851939
51MP0003453_abnormal_keratinocyte_physiol1.43035805
52MP0002132_abnormal_respiratory_system1.31540603
53MP0005397_hematopoietic_system_phenotyp1.31357006
54MP0001545_abnormal_hematopoietic_system1.31357006
55MP0003690_abnormal_glial_cell1.29108488
56MP0001873_stomach_inflammation1.27483276
57MP0003806_abnormal_nucleotide_metabolis1.26994927
58MP0008004_abnormal_stomach_pH1.26878508
59MP0009764_decreased_sensitivity_to1.23943505
60MP0004808_abnormal_hematopoietic_stem1.21479854
61MP0002139_abnormal_hepatobiliary_system1.21470473
62MP0003448_altered_tumor_morphology1.21068446
63MP0000604_amyloidosis1.19264749
64MP0002933_joint_inflammation1.16342685
65MP0002998_abnormal_bone_remodeling1.13101871
66MP0005166_decreased_susceptibility_to1.13056102
67MP0005174_abnormal_tail_pigmentation1.12481552
68MP0003763_abnormal_thymus_physiology1.08400001
69MP0000858_altered_metastatic_potential1.07625323
70MP0010307_abnormal_tumor_latency1.01133424
71MP0000569_abnormal_digit_pigmentation1.00023889
72MP0003566_abnormal_cell_adhesion0.97454008
73MP0003705_abnormal_hypodermis_morpholog0.96093244
74MP0009763_increased_sensitivity_to0.95031553
75MP0001851_eye_inflammation0.94813491
76MP0001849_ear_inflammation0.94166885
77MP0000703_abnormal_thymus_morphology0.92387198
78MP0000249_abnormal_blood_vessel0.92320120
79MP0000490_abnormal_crypts_of0.92067134
80MP0006054_spinal_hemorrhage0.91158282
81MP0002277_abnormal_respiratory_mucosa0.90220087
82MP0003866_abnormal_defecation0.85907242
83MP0003828_pulmonary_edema0.85483289
84MP0002136_abnormal_kidney_physiology0.81911409
85MP0003656_abnormal_erythrocyte_physiolo0.81214239
86MP0000609_abnormal_liver_physiology0.79246082
87MP0005390_skeleton_phenotype0.76610588
88MP0010234_abnormal_vibrissa_follicle0.76492911
89MP0003329_amyloid_beta_deposits0.73858702
90MP0002138_abnormal_hepatobiliary_system0.72261053
91MP0005165_increased_susceptibility_to0.72235075
92MP0000767_abnormal_smooth_muscle0.69755913
93MP0000015_abnormal_ear_pigmentation0.69631125
94MP0005076_abnormal_cell_differentiation0.68977689
95MP0004858_abnormal_nervous_system0.67550703
96MP0005164_abnormal_response_to0.66424498
97MP0002019_abnormal_tumor_incidence0.66172821
98MP0005167_abnormal_blood-brain_barrier0.65964124
99MP0008874_decreased_physiological_sensi0.65784593
100MP0004883_abnormal_blood_vessel0.65520405
101MP0002332_abnormal_exercise_endurance0.65487661
102MP0008873_increased_physiological_sensi0.65383772
103MP0005584_abnormal_enzyme/coenzyme_acti0.63688669
104MP0000598_abnormal_liver_morphology0.63207054
105MP0001663_abnormal_digestive_system0.63170248
106MP0002877_abnormal_melanocyte_morpholog0.62957726
107MP0000371_diluted_coat_color0.62898968
108MP0002928_abnormal_bile_duct0.62382335
109MP0001915_intracranial_hemorrhage0.62125815
110MP0004185_abnormal_adipocyte_glucose0.61869961
111MP0003795_abnormal_bone_structure0.60634454
112MP0009765_abnormal_xenobiotic_induced0.60538913
113MP0005023_abnormal_wound_healing0.60317111
114MP0005319_abnormal_enzyme/_coenzyme0.60145567
115MP0003045_fibrosis0.60100722
116MP0005381_digestive/alimentary_phenotyp0.59173352
117MP0004782_abnormal_surfactant_physiolog0.59027279
118MP0002254_reproductive_system_inflammat0.58198049
119MP0003091_abnormal_cell_migration0.56711346
120MP0003279_aneurysm0.55838220
121MP0010352_gastrointestinal_tract_polyps0.53997178

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.24830845
2Systemic lupus erythematosus (HP:0002725)5.83729765
3Recurrent bacterial skin infections (HP:0005406)5.82183365
4Eczematoid dermatitis (HP:0000976)5.20929524
5Glomerulonephritis (HP:0000099)4.61163764
6Recurrent gram-negative bacterial infections (HP:0005420)4.56897629
7Cellulitis (HP:0100658)4.48452040
8Agammaglobulinemia (HP:0004432)4.28211046
9Vacuolated lymphocytes (HP:0001922)4.06241977
10Increased cerebral lipofuscin (HP:0011813)4.03865974
11Colitis (HP:0002583)4.01936639
12Abnormality of macrophages (HP:0004311)3.85296843
13Recurrent skin infections (HP:0001581)3.80477801
14Abnormality of glycolipid metabolism (HP:0010969)3.71493851
15Abnormality of liposaccharide metabolism (HP:0010968)3.71493851
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.71493851
17Dysostosis multiplex (HP:0000943)3.67258810
18Chronic otitis media (HP:0000389)3.63625091
19Mediastinal lymphadenopathy (HP:0100721)3.58893339
20Elevated erythrocyte sedimentation rate (HP:0003565)3.58291359
21Recurrent fungal infections (HP:0002841)3.56307687
22Meningitis (HP:0001287)3.55697056
23Inflammation of the large intestine (HP:0002037)3.53998497
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.52167397
25Complement deficiency (HP:0004431)3.46686620
26Myositis (HP:0100614)3.43406368
27* Recurrent viral infections (HP:0004429)3.41657954
28Gastrointestinal inflammation (HP:0004386)3.39730669
29Gastrointestinal stroma tumor (HP:0100723)3.38774967
30IgM deficiency (HP:0002850)3.38659555
31Recurrent bronchitis (HP:0002837)3.37860820
32Spontaneous hematomas (HP:0007420)3.28828152
33Osteomyelitis (HP:0002754)3.23453478
34Vasculitis (HP:0002633)3.22237599
35Chronic obstructive pulmonary disease (HP:0006510)3.21135791
36Obstructive lung disease (HP:0006536)3.21135791
37Abnormality of complement system (HP:0005339)3.20631444
38Urinary glycosaminoglycan excretion (HP:0003541)3.00682032
39Mucopolysacchariduria (HP:0008155)3.00682032
40Autoimmune thrombocytopenia (HP:0001973)2.97385183
41Recurrent pneumonia (HP:0006532)2.95306608
42Gingivitis (HP:0000230)2.93967143
43Disinhibition (HP:0000734)2.93940623
44Hematochezia (HP:0002573)2.89756768
45Interstitial pulmonary disease (HP:0006530)2.83011166
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.82606818
47Abnormality of polysaccharide metabolism (HP:0011012)2.82606818
48Abnormality of glycosaminoglycan metabolism (HP:0004371)2.82606818
49Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.76510112
50Nephritis (HP:0000123)2.74498021
51Recurrent cutaneous fungal infections (HP:0011370)2.74433046
52Chronic mucocutaneous candidiasis (HP:0002728)2.74433046
53Amyloidosis (HP:0011034)2.73731428
54Panhypogammaglobulinemia (HP:0003139)2.71548360
55Purpura (HP:0000979)2.69727982
56Recurrent sinusitis (HP:0011108)2.69063330
57Pustule (HP:0200039)2.67792108
58Verrucae (HP:0200043)2.66841816
59Papilloma (HP:0012740)2.66841816
60Recurrent lower respiratory tract infections (HP:0002783)2.66420773
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.65730738
62Loss of speech (HP:0002371)2.65452983
63Emphysema (HP:0002097)2.62118956
64Orchitis (HP:0100796)2.61920306
65Thrombocytosis (HP:0001894)2.61359941
66Gastrointestinal infarctions (HP:0005244)2.60639998
67Increased serum ferritin (HP:0003281)2.59684914
68Periodontitis (HP:0000704)2.57268062
69Lymphopenia (HP:0001888)2.51288990
70Keratoconjunctivitis sicca (HP:0001097)2.50833686
71Axonal loss (HP:0003447)2.49958949
72Agnosia (HP:0010524)2.48389382
73Sepsis (HP:0100806)2.44278306
74Encephalitis (HP:0002383)2.43388322
75Myocardial infarction (HP:0001658)2.42689256
76Abnormality of cells of the lymphoid lineage (HP:0012140)2.42007014
77Chronic sinusitis (HP:0011109)2.34670324
78Malnutrition (HP:0004395)2.33954106
79Pulmonary infiltrates (HP:0002113)2.33195654
80Nasal polyposis (HP:0100582)2.32301454
81Urticaria (HP:0001025)2.30620513
82Hemoptysis (HP:0002105)2.30226687
83Restrictive lung disease (HP:0002091)2.29642057
84Thyroiditis (HP:0100646)2.27952030
85Petechiae (HP:0000967)2.27256406
86Abnormality of B cell number (HP:0010975)2.27178643
87B lymphocytopenia (HP:0010976)2.27178643
88Basal ganglia calcification (HP:0002135)2.27024060
89Abnormality of the nasal mucosa (HP:0000433)2.24824164
90Abnormality of T cell physiology (HP:0011840)2.23640214
91Nuclear cataract (HP:0100018)2.23184118
92Keratoconjunctivitis (HP:0001096)2.23171747
93Thoracic kyphosis (HP:0002942)2.20977761
94Retrobulbar optic neuritis (HP:0100654)2.20521244
95Optic neuritis (HP:0100653)2.20521244
96Premature loss of primary teeth (HP:0006323)2.15969578
97Hepatosplenomegaly (HP:0001433)2.15801056
98Arterial thrombosis (HP:0004420)2.15665830
99Leukocytosis (HP:0001974)2.13523845
100Joint hemorrhage (HP:0005261)2.13266978
101Increased IgM level (HP:0003496)2.11562560
102Eosinophilia (HP:0001880)2.09778052
103Spondylolisthesis (HP:0003302)2.08997445
104Skin ulcer (HP:0200042)2.08967235
105Abnormality of iron homeostasis (HP:0011031)2.08443896
106Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07169151
107Chronic diarrhea (HP:0002028)2.06341352
108Hypergammaglobulinemia (HP:0010702)2.06065540
109Gingival bleeding (HP:0000225)2.05510226
110Stomatitis (HP:0010280)2.04790560
111Epistaxis (HP:0000421)2.03298338
112Neuronal loss in central nervous system (HP:0002529)2.02198049
113Chest pain (HP:0100749)2.01231996
114Polygenic inheritance (HP:0010982)1.99724835
115Mitral stenosis (HP:0001718)1.99502397
116Increased IgE level (HP:0003212)1.99120252
117Progressive neurologic deterioration (HP:0002344)1.98625965
118Prolonged bleeding time (HP:0003010)1.97018663
119Upper motor neuron abnormality (HP:0002127)1.96152423
120Hypertensive crisis (HP:0100735)1.95232592
121Abnormality of T cells (HP:0002843)1.93641389
122Mutism (HP:0002300)1.87425042
123Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87264201
124Pulmonary embolism (HP:0002204)1.87154911
125Pathologic fracture (HP:0002756)1.84580517
126Dynein arm defect of respiratory motile cilia (HP:0012255)1.84095504
127Absent/shortened dynein arms (HP:0200106)1.84095504
128Anorexia (HP:0002039)1.83791857

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.41179322
2BLK3.98052030
3ERN13.64620335
4TYK23.17916912
5RIPK43.16961382
6TGFBR23.11552935
7CSF1R3.05300854
8IRAK42.89713278
9PRPF4B2.82948507
10TBK12.76616113
11MAP3K142.64896035
12KIT2.60513153
13MAP3K102.32808071
14IRAK32.26816538
15BTK2.06964189
16SMG12.02970795
17SYK1.99643341
18TAOK11.89637994
19JAK11.80880113
20TAOK21.77954273
21STK101.72333050
22JAK31.71339886
23IKBKE1.70814716
24IKBKB1.70706870
25ZAP701.69863840
26GRK61.63184192
27MAP3K131.62539327
28CSK1.53679818
29HCK1.51700698
30FES1.50638264
31LYN1.46789794
32TEC1.42149357
33MAP2K31.41621898
34TRIB31.34024452
35TAOK31.32043557
36CLK11.28884828
37EPHB11.26284161
38LRRK21.23440683
39MATK1.20939592
40MAP3K11.20474905
41PKN21.18858384
42LCK1.18320050
43CDC42BPA1.17736517
44EEF2K1.14521213
45IRAK21.13396219
46CAMK1D1.11908897
47SIK21.08404474
48ITK1.02861002
49TESK21.02293435
50JAK20.95536235
51FLT30.93432943
52ICK0.92898327
53EPHA20.90210702
54GRK70.89660248
55PIM10.88575578
56MARK20.87680688
57IRAK10.87236386
58CHUK0.86739935
59NEK90.84954299
60RPS6KA40.84922574
61MARK30.84730056
62PRKD20.82926724
63SCYL20.82128379
64FGFR40.72644231
65PAK40.72190679
66TXK0.70254068
67BMPR20.70053463
68TESK10.69515305
69PTK60.67857802
70DDR20.67610230
71CAMK1G0.67141020
72STK40.65198762
73FGR0.63709539
74MST1R0.60691243
75KSR20.59737411
76ARAF0.58961146
77MAPK150.58423272
78FGFR30.58132473
79ABL10.57138105
80NME20.56267739
81PIM20.55320756
82EGFR0.52819481
83MAPK40.52591200
84PDK10.50643599
85CDK40.50177546
86CDK60.49520594
87RPS6KA20.49495344
88MAPK120.49372581
89PRKCD0.49232131
90MAP3K60.48813338
91ABL20.48085841
92MAP3K30.47175827
93PIK3CG0.46715525
94TTN0.46474823
95MAPKAPK20.45362533
96RPS6KA60.44508034
97RIPK10.41700497
98MAP2K60.41385520
99MAP3K110.41246981
100MAP3K80.40834046
101MAP2K20.38565045
102YES10.38521817
103KDR0.38497065
104CDK120.37686716
105TRPM70.37226196
106PRKCQ0.37029242
107MAP3K50.36542277
108PRKG20.36092222
109MAPK110.35644363
110FYN0.34549881
111RPS6KC10.34418814
112RPS6KL10.34418814
113MAPK70.34301849
114EIF2AK30.34218076
115MOS0.33409920
116SIK10.31879202
117TNK20.31469128
118PDPK10.30281189
119NEK20.28743848
120HIPK20.27754690
121IGF1R0.26595772
122CDK90.26138716
123CAMKK20.24643396
124DYRK1B0.24507711
125SIK30.24387383
126CAMKK10.24004366
127BMX0.23740561

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.98254223
2B cell receptor signaling pathway_Homo sapiens_hsa046623.41590067
3Leishmaniasis_Homo sapiens_hsa051403.24315976
4Glycosaminoglycan degradation_Homo sapiens_hsa005313.07571681
5Other glycan degradation_Homo sapiens_hsa005112.92691542
6Osteoclast differentiation_Homo sapiens_hsa043802.83283184
7Primary immunodeficiency_Homo sapiens_hsa053402.69459267
8Lysosome_Homo sapiens_hsa041422.45807624
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.44750474
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.39272999
11Pertussis_Homo sapiens_hsa051332.37944661
12Autoimmune thyroid disease_Homo sapiens_hsa053202.34443890
13Antigen processing and presentation_Homo sapiens_hsa046122.25728116
14Tuberculosis_Homo sapiens_hsa051522.11117650
15Legionellosis_Homo sapiens_hsa051341.93405636
16Measles_Homo sapiens_hsa051621.92761069
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.92662442
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.91935124
19Hematopoietic cell lineage_Homo sapiens_hsa046401.86837611
20Malaria_Homo sapiens_hsa051441.72671958
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.65165697
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64426875
23Toxoplasmosis_Homo sapiens_hsa051451.58219268
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58168097
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57898930
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57868940
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56151541
28Influenza A_Homo sapiens_hsa051641.55993815
29Complement and coagulation cascades_Homo sapiens_hsa046101.50640815
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48169318
31Herpes simplex infection_Homo sapiens_hsa051681.41699031
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40461449
33Chemokine signaling pathway_Homo sapiens_hsa040621.38820512
34Apoptosis_Homo sapiens_hsa042101.28234042
35Salmonella infection_Homo sapiens_hsa051321.27606040
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27073303
37Phagosome_Homo sapiens_hsa041451.27044665
38Shigellosis_Homo sapiens_hsa051311.23904204
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.16886993
40TNF signaling pathway_Homo sapiens_hsa046681.15670329
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.14470766
42Caffeine metabolism_Homo sapiens_hsa002321.12154295
43Hepatitis B_Homo sapiens_hsa051611.08405103
44Graft-versus-host disease_Homo sapiens_hsa053321.03900288
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00246250
46Rheumatoid arthritis_Homo sapiens_hsa053230.99446699
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95572432
48Platelet activation_Homo sapiens_hsa046110.95511285
49Acute myeloid leukemia_Homo sapiens_hsa052210.95005005
50Chronic myeloid leukemia_Homo sapiens_hsa052200.94199614
51African trypanosomiasis_Homo sapiens_hsa051430.89768687
52Allograft rejection_Homo sapiens_hsa053300.89233562
53Pancreatic cancer_Homo sapiens_hsa052120.87873608
54T cell receptor signaling pathway_Homo sapiens_hsa046600.86365972
55Prion diseases_Homo sapiens_hsa050200.84077725
56Hepatitis C_Homo sapiens_hsa051600.83479703
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82303170
58Bladder cancer_Homo sapiens_hsa052190.81986556
59Asthma_Homo sapiens_hsa053100.80122914
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78626572
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.77327065
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73707741
63Viral myocarditis_Homo sapiens_hsa054160.72656294
64Epstein-Barr virus infection_Homo sapiens_hsa051690.70182137
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68222218
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63818100
67Galactose metabolism_Homo sapiens_hsa000520.62618481
68ABC transporters_Homo sapiens_hsa020100.61622490
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58156748
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57828089
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55940533
72Fructose and mannose metabolism_Homo sapiens_hsa000510.55257190
73Non-homologous end-joining_Homo sapiens_hsa034500.52021371
74Endocytosis_Homo sapiens_hsa041440.50005999
75Amoebiasis_Homo sapiens_hsa051460.49544122
76Renal cell carcinoma_Homo sapiens_hsa052110.49162325
77Non-small cell lung cancer_Homo sapiens_hsa052230.48360502
78Viral carcinogenesis_Homo sapiens_hsa052030.48353731
79Systemic lupus erythematosus_Homo sapiens_hsa053220.44834390
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.42517697
81Renin-angiotensin system_Homo sapiens_hsa046140.41054701
82Collecting duct acid secretion_Homo sapiens_hsa049660.40477307
83Insulin resistance_Homo sapiens_hsa049310.40297870
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.40117976
85Notch signaling pathway_Homo sapiens_hsa043300.39662438
86Base excision repair_Homo sapiens_hsa034100.37470007
87Pentose phosphate pathway_Homo sapiens_hsa000300.35921275
88GnRH signaling pathway_Homo sapiens_hsa049120.35852843
89HTLV-I infection_Homo sapiens_hsa051660.35332638
90Prolactin signaling pathway_Homo sapiens_hsa049170.34688418
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34677768
92VEGF signaling pathway_Homo sapiens_hsa043700.34407449
93N-Glycan biosynthesis_Homo sapiens_hsa005100.34286016
94Vibrio cholerae infection_Homo sapiens_hsa051100.34095418
95HIF-1 signaling pathway_Homo sapiens_hsa040660.33955335
96mTOR signaling pathway_Homo sapiens_hsa041500.33708214
97Small cell lung cancer_Homo sapiens_hsa052220.33331218
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.31625218
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31284898
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30831224
101Endometrial cancer_Homo sapiens_hsa052130.30732312
102Type II diabetes mellitus_Homo sapiens_hsa049300.25885875
103Choline metabolism in cancer_Homo sapiens_hsa052310.25178401
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23826744
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.23214780
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22037777
107Type I diabetes mellitus_Homo sapiens_hsa049400.19407734
108DNA replication_Homo sapiens_hsa030300.18387650
109Colorectal cancer_Homo sapiens_hsa052100.17146607
110FoxO signaling pathway_Homo sapiens_hsa040680.14807324
111Proteoglycans in cancer_Homo sapiens_hsa052050.14322622
112Sphingolipid metabolism_Homo sapiens_hsa006000.13324603
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12685615
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12480016
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11728308
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.10545594

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