UNC93B6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to growth hormone stimulus (GO:0071378)8.97226188
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.12801935
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.12801935
4modulation by symbiont of host immune response (GO:0052553)6.12801935
5positive regulation by symbiont of host defense response (GO:0052509)6.12801935
6modulation by symbiont of host defense response (GO:0052031)6.12801935
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.12801935
8JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)6.09509940
9macrophage activation involved in immune response (GO:0002281)6.03104102
10positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)5.88039509
11T-helper 1 type immune response (GO:0042088)5.82115324
12positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.24383316
13detection of molecule of bacterial origin (GO:0032490)4.70281450
14regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)4.61615517
15response to growth hormone (GO:0060416)4.58924164
16regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.42386069
17hydrogen peroxide biosynthetic process (GO:0050665)4.41858413
18response to host immune response (GO:0052572)4.37249014
19response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.37249014
20microglial cell activation (GO:0001774)4.30284377
21negative regulation of bone mineralization (GO:0030502)4.25669576
22cellular response to thyroid hormone stimulus (GO:0097067)4.06640158
23positive regulation of chemokine biosynthetic process (GO:0045080)3.91784214
24reactive oxygen species biosynthetic process (GO:1903409)3.87721447
25response to peptidoglycan (GO:0032494)3.84041319
26response to host defenses (GO:0052200)3.83659056
27response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.83659056
28response to host (GO:0075136)3.83659056
29positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)3.82975802
30positive regulation of receptor internalization (GO:0002092)3.81989201
31regulation of interferon-alpha production (GO:0032647)3.81070340
32negative regulation of biomineral tissue development (GO:0070168)3.77346012
33regulation of vitamin D biosynthetic process (GO:0060556)3.75821651
34JAK-STAT cascade (GO:0007259)3.73772487
35regulation of T-helper 1 cell differentiation (GO:0045625)3.66985683
36regulation of interferon-beta biosynthetic process (GO:0045357)3.55774479
37response to protozoan (GO:0001562)3.54673052
38cellular response to type I interferon (GO:0071357)3.48624474
39type I interferon signaling pathway (GO:0060337)3.48624474
40regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516)3.44018068
41regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.43533856
42response to type I interferon (GO:0034340)3.42567562
43negative regulation of interleukin-12 production (GO:0032695)3.41137888
44regulation of chemokine biosynthetic process (GO:0045073)3.40086857
45macrophage activation (GO:0042116)3.34834987
46regulation of cytokine secretion involved in immune response (GO:0002739)3.34498822
47positive regulation of gamma-delta T cell activation (GO:0046645)3.33597048
48regulation of interleukin-6 biosynthetic process (GO:0045408)3.33495287
49activation of MAPKKK activity (GO:0000185)3.30170651
50positive regulation of interferon-alpha production (GO:0032727)3.29200886
51detection of external biotic stimulus (GO:0098581)3.28547150
52positive regulation of heat generation (GO:0031652)3.26378397
53immunoglobulin mediated immune response (GO:0016064)3.22497863
54dendritic cell differentiation (GO:0097028)3.20759181
55regulation of chronic inflammatory response (GO:0002676)3.20390269
56negative regulation of viral genome replication (GO:0045071)3.17842373
57defense response to protozoan (GO:0042832)3.11209387
58lipopolysaccharide-mediated signaling pathway (GO:0031663)3.10353181
59myeloid cell activation involved in immune response (GO:0002275)3.06687452
60neutrophil activation involved in immune response (GO:0002283)3.05147571
61positive regulation of NF-kappaB import into nucleus (GO:0042346)3.04144320
62positive regulation of osteoblast proliferation (GO:0033690)3.02409476
63positive regulation of interleukin-6 production (GO:0032755)3.00704908
64positive regulation of interferon-beta production (GO:0032728)2.97153135
65regulation of interleukin-8 biosynthetic process (GO:0045414)2.96751836
66response to thyroid hormone (GO:0097066)2.94492049
67negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.94259152
68positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.93229523
69regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.91378188
70myeloid dendritic cell differentiation (GO:0043011)2.88371521
71NIK/NF-kappaB signaling (GO:0038061)2.88133569
72branching involved in labyrinthine layer morphogenesis (GO:0060670)2.86067856
73positive regulation of cytokine biosynthetic process (GO:0042108)2.83883150
74germinal center formation (GO:0002467)2.82997951
75positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)2.82966164
76regulation of mitochondrial membrane permeability (GO:0046902)2.82634030
77purine nucleotide salvage (GO:0032261)2.81925658
78regulation of vitamin metabolic process (GO:0030656)2.81772276
79detection of biotic stimulus (GO:0009595)2.79145920
80negative regulation of myeloid cell apoptotic process (GO:0033033)2.75616059
81regulation of B cell apoptotic process (GO:0002902)2.73059229
82interferon-gamma-mediated signaling pathway (GO:0060333)2.72361257
83T cell migration (GO:0072678)2.71819650
84superoxide anion generation (GO:0042554)2.71717915
85regulation of podosome assembly (GO:0071801)2.71486554
86negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.71478665
87regulation of membrane permeability (GO:0090559)2.69058845
88positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.67888655
89regulation of interleukin-6 production (GO:0032675)2.67644666
90negative regulation of cytokine production involved in immune response (GO:0002719)2.67363046
91regulation of fever generation (GO:0031620)2.66883074
92regulation of tyrosine phosphorylation of STAT protein (GO:0042509)2.59542335
93granulocyte differentiation (GO:0030851)2.58986715
94monocyte chemotaxis (GO:0002548)2.55665680
95regulation of mast cell degranulation (GO:0043304)2.55001181
96myeloid dendritic cell activation (GO:0001773)2.53804453
97negative regulation of interleukin-17 production (GO:0032700)2.48634786
98regulation of mast cell activation involved in immune response (GO:0033006)2.48038651
99regulation of activation of Janus kinase activity (GO:0010533)11.7617194
100growth hormone receptor signaling pathway (GO:0060396)10.1943685

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.12819233
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.15414449
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.63033182
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.52993253
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.28393648
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.25809868
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.13444061
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.06144526
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.00747039
10VDR_21846776_ChIP-Seq_THP-1_Human3.00602303
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.88395877
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.77798181
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.69708480
14STAT1_20625510_ChIP-Seq_HELA_Human2.65831986
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65398040
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.55252430
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41014995
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.40733851
19SPI1_23547873_ChIP-Seq_NB4_Human2.34375084
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.21235860
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.19268917
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.18510770
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.13272635
24VDR_24763502_ChIP-Seq_THP-1_Human2.12383255
25SPI1_23127762_ChIP-Seq_K562_Human2.04135075
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.99056933
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.94612952
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83167940
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82363920
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.81471184
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.81471184
32KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.81471184
33SRY_22984422_ChIP-ChIP_TESTIS_Rat1.79383304
34VDR_24787735_ChIP-Seq_THP-1_Human1.73659733
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69981518
36MAF_26560356_Chip-Seq_TH1_Human1.69939311
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.66627621
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66421655
39ZNF263_19887448_ChIP-Seq_K562_Human1.65457465
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.58793990
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58156994
42LXR_22292898_ChIP-Seq_THP-1_Human1.56564628
43GATA1_19941826_ChIP-Seq_K562_Human1.54571941
44UTX_26944678_Chip-Seq_JUKART_Human1.53178578
45MYB_26560356_Chip-Seq_TH2_Human1.52172367
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.46973773
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44098198
48GATA1_22025678_ChIP-Seq_K562_Human1.42543492
49RUNX_20019798_ChIP-Seq_JUKART_Human1.42258269
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39458500
51PU.1_20513432_ChIP-Seq_Bcells_Mouse1.39376977
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.39131068
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38944907
54MAF_26560356_Chip-Seq_TH2_Human1.38240111
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.36570131
56TFEB_21752829_ChIP-Seq_HELA_Human1.36547800
57KDM2B_26808549_Chip-Seq_DND41_Human1.35078832
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34515159
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33489915
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33053185
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26609426
62CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25184212
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24953894
64MYB_26560356_Chip-Seq_TH1_Human1.24756883
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23581103
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23473888
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19731722
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19537350
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19190413
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18585765
71MYC_22102868_ChIP-Seq_BL_Human1.18126449
72PU_27001747_Chip-Seq_BMDM_Mouse1.17227439
73BCL6_27268052_Chip-Seq_Bcells_Human1.15276181
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12104378
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.10426160
76NCOR1_26117541_ChIP-Seq_K562_Human1.09970619
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.09358086
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08200371
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07553185
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06709055
81TCF7_22412390_ChIP-Seq_EML_Mouse1.06300667
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04034826
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03595526
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02758281
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01845487
86CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01794433
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00346426
88HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98540658
89FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97811935
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97676556
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96259800
92GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94880703
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93226293
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88457359
95SA1_27219007_Chip-Seq_Bcells_Human0.87233011
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86124551
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85995025
98CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85570380
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85195686
100GATA3_26560356_Chip-Seq_TH2_Human0.79594055

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition6.48233157
2MP0003303_peritoneal_inflammation5.37864855
3MP0002139_abnormal_hepatobiliary_system3.42437755
4MP0003436_decreased_susceptibility_to3.41008547
5MP0002148_abnormal_hypersensitivity_rea3.38642776
6MP0009785_altered_susceptibility_to3.09208560
7MP0004510_myositis2.97519644
8MP0002132_abnormal_respiratory_system2.92998936
9MP0003724_increased_susceptibility_to2.92914374
10MP0001835_abnormal_antigen_presentation2.88060854
11MP0006082_CNS_inflammation2.83197027
12MP0005000_abnormal_immune_tolerance2.45066211
13MP0005387_immune_system_phenotype2.41660751
14MP0001790_abnormal_immune_system2.41660751
15MP0005025_abnormal_response_to2.36418928
16MP0003195_calcinosis2.36350919
17MP0008004_abnormal_stomach_pH2.36071650
18MP0005671_abnormal_response_to2.28763796
19MP0005058_abnormal_lysosome_morphology2.27719236
20MP0002723_abnormal_immune_serum2.22496569
21MP0003453_abnormal_keratinocyte_physiol2.18332975
22MP0002419_abnormal_innate_immunity2.17175985
23MP0003300_gastrointestinal_ulcer2.17124853
24MP0002452_abnormal_antigen_presenting2.01214761
25MP0001800_abnormal_humoral_immune2.00527481
26MP0000685_abnormal_immune_system1.99028106
27MP0003806_abnormal_nucleotide_metabolis1.82263952
28MP0009764_decreased_sensitivity_to1.76593797
29MP0004947_skin_inflammation1.75341686
30MP0001545_abnormal_hematopoietic_system1.74904617
31MP0005397_hematopoietic_system_phenotyp1.74904617
32MP0002420_abnormal_adaptive_immunity1.70319569
33MP0001819_abnormal_immune_cell1.69788504
34MP0000343_altered_response_to1.64476335
35MP0001845_abnormal_inflammatory_respons1.59188952
36MP0001533_abnormal_skeleton_physiology1.54397704
37MP0000678_abnormal_parathyroid_gland1.51895939
38MP0009333_abnormal_splenocyte_physiolog1.47957317
39MP0008469_abnormal_protein_level1.43896383
40MP0001853_heart_inflammation1.42152272
41MP0010155_abnormal_intestine_physiology1.39802079
42MP0003075_altered_response_to1.39049681
43MP0000767_abnormal_smooth_muscle1.38104505
44MP0009840_abnormal_foam_cell1.36398407
45MP0003828_pulmonary_edema1.35588340
46MP0000716_abnormal_immune_system1.35092229
47MP0002405_respiratory_system_inflammati1.34530028
48MP0002254_reproductive_system_inflammat1.31801026
49MP0002332_abnormal_exercise_endurance1.29543070
50MP0002398_abnormal_bone_marrow1.26574970
51MP0003448_altered_tumor_morphology1.21191354
52MP0002933_joint_inflammation1.19308081
53MP0006054_spinal_hemorrhage1.18251850
54MP0005310_abnormal_salivary_gland1.14147967
55MP0000858_altered_metastatic_potential1.10229656
56MP0002722_abnormal_immune_system1.09817289
57MP0002429_abnormal_blood_cell1.05115885
58MP0002998_abnormal_bone_remodeling1.04248373
59MP0004185_abnormal_adipocyte_glucose1.02887701
60MP0009278_abnormal_bone_marrow1.00495554
61MP0005647_abnormal_sex_gland0.99854389
62MP0000689_abnormal_spleen_morphology0.97602772
63MP0003183_abnormal_peptide_metabolism0.93764870
64MP0005166_decreased_susceptibility_to0.92046241
65MP0001663_abnormal_digestive_system0.92002391
66MP0001348_abnormal_lacrimal_gland0.89415009
67MP0001849_ear_inflammation0.87377292
68MP0010234_abnormal_vibrissa_follicle0.86150646
69MP0002837_dystrophic_cardiac_calcinosis0.82920084
70MP0001542_abnormal_bone_strength0.80908413
71MP0008874_decreased_physiological_sensi0.80382431
72MP0003221_abnormal_cardiomyocyte_apopto0.76835505
73MP0003186_abnormal_redox_activity0.76121614
74MP0009763_increased_sensitivity_to0.73907133
75MP0000703_abnormal_thymus_morphology0.73257447
76MP0010307_abnormal_tumor_latency0.72006149
77MP0000604_amyloidosis0.71916721
78MP0005464_abnormal_platelet_physiology0.70657039
79MP0005076_abnormal_cell_differentiation0.70172747
80MP0005164_abnormal_response_to0.69578341
81MP0003172_abnormal_lysosome_physiology0.67414097
82MP0003656_abnormal_erythrocyte_physiolo0.67026099
83MP0001661_extended_life_span0.66612000
84MP0002277_abnormal_respiratory_mucosa0.65756002
85MP0000490_abnormal_crypts_of0.65119717
86MP0006036_abnormal_mitochondrial_physio0.64200098
87MP0005381_digestive/alimentary_phenotyp0.63840845
88MP0001919_abnormal_reproductive_system0.63449197
89MP0003763_abnormal_thymus_physiology0.63047980
90MP0002163_abnormal_gland_morphology0.62419406
91MP0003890_abnormal_embryonic-extraembry0.60602742
92MP0008875_abnormal_xenobiotic_pharmacok0.60251937
93MP0001764_abnormal_homeostasis0.58772452
94MP0004883_abnormal_blood_vessel0.58480694
95MP0005266_abnormal_metabolism0.57812408
96MP0008872_abnormal_physiological_respon0.56391874
97MP0005390_skeleton_phenotype0.56253227
98MP0005165_increased_susceptibility_to0.54980786
99MP0001873_stomach_inflammation0.53719493
100MP0004808_abnormal_hematopoietic_stem0.53347430

Predicted human phenotypes

RankGene SetZ-score
1Short middle phalanx of the 5th finger (HP:0004220)6.25559068
2Abnormality of glycolipid metabolism (HP:0010969)5.26171149
3Abnormality of liposaccharide metabolism (HP:0010968)5.26171149
4Abnormality of glycosphingolipid metabolism (HP:0004343)5.26171149
5Petechiae (HP:0000967)5.08782603
6Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)4.68074331
7Eczematoid dermatitis (HP:0000976)4.31033624
8Deep palmar crease (HP:0006191)4.23714583
9Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)4.18536065
10Acanthocytosis (HP:0001927)3.99817556
11Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.98911471
12Vacuolated lymphocytes (HP:0001922)3.93929670
13Recurrent bacterial skin infections (HP:0005406)3.93293092
14Severe short stature (HP:0003510)3.85085488
15Increased cerebral lipofuscin (HP:0011813)3.84342521
16Nuclear cataract (HP:0100018)3.83778750
17Stomatitis (HP:0010280)3.80503240
18Abnormality of macrophages (HP:0004311)3.62577473
19Abnormality of the phalanges of the 5th finger (HP:0004213)3.61390305
20Abnormal platelet function (HP:0011869)3.55172154
21Impaired platelet aggregation (HP:0003540)3.55172154
22Mediastinal lymphadenopathy (HP:0100721)3.51924299
23Increased neuronal autofluorescent lipopigment (HP:0002074)3.42977650
24Gastrointestinal stroma tumor (HP:0100723)3.39884158
25Recurrent abscess formation (HP:0002722)3.37701938
26Optic neuritis (HP:0100653)3.36293860
27Retrobulbar optic neuritis (HP:0100654)3.36293860
28Disinhibition (HP:0000734)3.33756931
29Systemic lupus erythematosus (HP:0002725)3.24617300
30Recurrent viral infections (HP:0004429)3.21883352
31Orchitis (HP:0100796)3.21255115
32Recurrent gram-negative bacterial infections (HP:0005420)3.11435331
33Recurrent fungal infections (HP:0002841)3.09644412
34Autoimmune thrombocytopenia (HP:0001973)3.00564437
35Growth hormone deficiency (HP:0000824)2.95480444
36Myositis (HP:0100614)2.88247432
37Dysostosis multiplex (HP:0000943)2.83041164
38Vasculitis (HP:0002633)2.62391193
39Loss of speech (HP:0002371)2.60004594
40Lymphopenia (HP:0001888)2.55067219
41Mutism (HP:0002300)2.44819528
42Obstructive lung disease (HP:0006536)2.44676025
43Chronic obstructive pulmonary disease (HP:0006510)2.44676025
44Protruding tongue (HP:0010808)2.44585245
45Keratoconjunctivitis sicca (HP:0001097)2.42975606
46Prolonged bleeding time (HP:0003010)2.42190169
47Abnormality of B cell number (HP:0010975)2.40915779
48Polycythemia (HP:0001901)2.40789299
49Short 5th finger (HP:0009237)2.31746929
50B lymphocytopenia (HP:0010976)2.31693578
51Acute necrotizing encephalopathy (HP:0006965)2.31340205
52Abnormal mitochondria in muscle tissue (HP:0008316)2.29746275
53Abnormality of the heme biosynthetic pathway (HP:0010472)2.27546542
54Urticaria (HP:0001025)2.26634804
55Poikilocytosis (HP:0004447)2.26319070
56Broad palm (HP:0001169)2.23205514
57Abnormality of cells of the lymphoid lineage (HP:0012140)2.21805532
58Brushfield spots (HP:0001088)2.20932392
59Inappropriate behavior (HP:0000719)2.18243268
60Parakeratosis (HP:0001036)2.17570617
61Keratoconjunctivitis (HP:0001096)2.16079599
62Progressive macrocephaly (HP:0004481)2.11524948
63Axonal loss (HP:0003447)2.08549066
64Meningitis (HP:0001287)2.08200427
65Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.07954029
66Glomerulonephritis (HP:0000099)2.04787815
67Recurrent skin infections (HP:0001581)2.02166180
68Pustule (HP:0200039)2.01395707
69Nausea (HP:0002018)2.00976872
70Nasal polyposis (HP:0100582)1.99037532
71Pulmonary infiltrates (HP:0002113)1.94221816
72Abnormality of dental color (HP:0011073)1.93827465
73Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93683191
74Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.92692157
75Reticulocytosis (HP:0001923)1.91769234
76Premature skin wrinkling (HP:0100678)1.91074746
77Respiratory difficulties (HP:0002880)1.89912320
78Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89329770
79Abnormality of the nasal mucosa (HP:0000433)1.88818151
80Mitochondrial inheritance (HP:0001427)1.88582873
81Acute encephalopathy (HP:0006846)1.88493352
82Testicular atrophy (HP:0000029)1.87153426
83Recurrent pneumonia (HP:0006532)1.84299466
84Purpura (HP:0000979)1.84020309
85Emphysema (HP:0002097)1.83936467
86T lymphocytopenia (HP:0005403)1.83814370
87Hematochezia (HP:0002573)1.83680040
88Arthralgia (HP:0002829)1.83649412
89Metaphyseal irregularity (HP:0003025)1.81702973
90Eosinophilia (HP:0001880)1.81367577
91Increased IgE level (HP:0003212)1.81339538
92Leukocytosis (HP:0001974)1.80683232
93Abnormal umbilical cord blood vessels (HP:0011403)1.80310684
94Single umbilical artery (HP:0001195)1.80310684
95Abnormality of the fetal cardiovascular system (HP:0010948)1.80310684
96Recurrent bronchitis (HP:0002837)1.76416968
97Progressive neurologic deterioration (HP:0002344)1.76269493
98Increased CSF lactate (HP:0002490)1.75880150
99Autoimmune hemolytic anemia (HP:0001890)1.74465232
100Hepatosplenomegaly (HP:0001433)1.73853166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.14647297
2BLK3.89302161
3ARAF3.81475208
4MAP3K113.74017077
5MAP4K13.38748264
6ERN13.04093370
7IRAK32.87662563
8MAP3K12.76638167
9MAP3K92.76082100
10BRAF2.59974276
11MOS2.52161755
12PDK22.44687113
13MAP3K132.42429692
14PIM22.26529669
15IRAK42.22896138
16JAK32.14378890
17GRK72.14369178
18TAOK12.02251498
19TYK21.96457197
20TBK11.81143117
21STK41.78791087
22IKBKE1.77511104
23MATK1.70635363
24MAP3K141.70186048
25RIPK41.66053303
26KSR21.65807749
27CDK121.56064273
28ACVR1B1.55527138
29TAOK21.53466191
30IKBKB1.48639969
31RAF11.23794181
32CSK1.20320616
33TGFBR21.19824777
34IRAK11.11710627
35PIM11.10096582
36TXK1.07139122
37RIPK10.99936468
38ADRBK20.98768325
39DDR20.97441840
40CHUK0.97391922
41SYK0.96114068
42BTK0.93751567
43JAK20.89784659
44PRPF4B0.87665959
45LYN0.85589714
46STK100.85362637
47MAP3K30.84433180
48CDK190.82414719
49CSF1R0.81855920
50FGR0.81641100
51IRAK20.81533525
52MARK30.79985895
53HIPK20.77463766
54TEC0.77320006
55ABL20.76471211
56PLK40.74986743
57TAOK30.74510102
58KSR10.74013746
59OXSR10.72555239
60CDK40.67879400
61GRK60.66567062
62ZAP700.65340624
63DYRK30.65318398
64BCKDK0.63276511
65TESK20.58080735
66MAP3K120.56474375
67HCK0.55252914
68CDK80.53891545
69LCK0.53543332
70BRSK20.53427240
71MAP2K30.53376580
72CAMKK20.51163198
73ITK0.50802861
74PIK3CG0.50760056
75PDPK10.50519256
76FES0.49433950
77MAP3K80.49145748
78PAK30.48802384
79LRRK20.47485128
80MAP3K50.45106515
81PDK10.42771710
82PAK10.39048689
83FER0.38027617
84AKT30.36183882
85JAK10.34951398
86EIF2AK20.32394351
87DAPK30.31317763
88EPHA30.30473796
89PKN10.29936455
90MARK20.29790984
91PRKD10.28208212
92RPS6KA10.24978080
93PRKCI0.24741121
94KIT0.24052117
95PRKCD0.21419947
96MAPK70.18664257
97INSR0.18145366
98MST40.17826112
99MAPK40.16087897
100TLK10.14385083

Predicted pathways (KEGG)

RankGene SetZ-score
1Toll-like receptor signaling pathway_Homo sapiens_hsa046203.29423221
2Leishmaniasis_Homo sapiens_hsa051403.11842964
3Allograft rejection_Homo sapiens_hsa053302.88639008
4Osteoclast differentiation_Homo sapiens_hsa043802.85035355
5Asthma_Homo sapiens_hsa053102.84360720
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.80254629
7Staphylococcus aureus infection_Homo sapiens_hsa051502.75329450
8Rheumatoid arthritis_Homo sapiens_hsa053232.61367409
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.48366194
10Tuberculosis_Homo sapiens_hsa051522.36766199
11Malaria_Homo sapiens_hsa051442.35456791
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.34011958
13Graft-versus-host disease_Homo sapiens_hsa053322.20984892
14Legionellosis_Homo sapiens_hsa051342.13081050
15Other glycan degradation_Homo sapiens_hsa005112.12468887
16Autoimmune thyroid disease_Homo sapiens_hsa053202.04886909
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01353044
18TNF signaling pathway_Homo sapiens_hsa046681.87313011
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.86954601
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.83872666
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.80387829
22Type I diabetes mellitus_Homo sapiens_hsa049401.74647667
23Caffeine metabolism_Homo sapiens_hsa002321.74153102
24Influenza A_Homo sapiens_hsa051641.69475789
25Salmonella infection_Homo sapiens_hsa051321.62116189
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62058330
27Lysosome_Homo sapiens_hsa041421.60549467
28Pertussis_Homo sapiens_hsa051331.60250884
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55919466
30B cell receptor signaling pathway_Homo sapiens_hsa046621.54670034
31Toxoplasmosis_Homo sapiens_hsa051451.53942058
32Systemic lupus erythematosus_Homo sapiens_hsa053221.52218442
33Antigen processing and presentation_Homo sapiens_hsa046121.43781005
34African trypanosomiasis_Homo sapiens_hsa051431.43076673
35Phagosome_Homo sapiens_hsa041451.41844439
36Herpes simplex infection_Homo sapiens_hsa051681.38990048
37Hematopoietic cell lineage_Homo sapiens_hsa046401.36628530
38Prion diseases_Homo sapiens_hsa050201.27800181
39Hepatitis B_Homo sapiens_hsa051611.25348085
40Measles_Homo sapiens_hsa051621.22129337
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15303266
42Hepatitis C_Homo sapiens_hsa051601.13675779
43Bladder cancer_Homo sapiens_hsa052191.10826940
44Primary immunodeficiency_Homo sapiens_hsa053401.08735062
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08064531
46Chemokine signaling pathway_Homo sapiens_hsa040621.07441629
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07335599
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06989320
49Acute myeloid leukemia_Homo sapiens_hsa052210.99648037
50Viral myocarditis_Homo sapiens_hsa054160.96257076
51Apoptosis_Homo sapiens_hsa042100.92163168
52Collecting duct acid secretion_Homo sapiens_hsa049660.88152063
53Epstein-Barr virus infection_Homo sapiens_hsa051690.84691446
54Dorso-ventral axis formation_Homo sapiens_hsa043200.82961086
55T cell receptor signaling pathway_Homo sapiens_hsa046600.82244068
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75080261
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73664376
58Oxidative phosphorylation_Homo sapiens_hsa001900.66156297
59Prolactin signaling pathway_Homo sapiens_hsa049170.66066871
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.65891195
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65309439
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64344886
63Non-small cell lung cancer_Homo sapiens_hsa052230.60874415
64Shigellosis_Homo sapiens_hsa051310.55373703
65HTLV-I infection_Homo sapiens_hsa051660.52637583
66Fatty acid biosynthesis_Homo sapiens_hsa000610.50624505
67Pancreatic cancer_Homo sapiens_hsa052120.49566230
68Glutathione metabolism_Homo sapiens_hsa004800.49538158
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49401326
70Amoebiasis_Homo sapiens_hsa051460.48312960
71Vibrio cholerae infection_Homo sapiens_hsa051100.44471327
72Sphingolipid metabolism_Homo sapiens_hsa006000.44367201
73Melanoma_Homo sapiens_hsa052180.40310119
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37913093
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.36941447
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34211797
77MAPK signaling pathway_Homo sapiens_hsa040100.34152234
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.33423674
79Parkinsons disease_Homo sapiens_hsa050120.32764471
80Galactose metabolism_Homo sapiens_hsa000520.32115259
81Chronic myeloid leukemia_Homo sapiens_hsa052200.30416722
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28796377
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28509199
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27965186
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.27747196
86Viral carcinogenesis_Homo sapiens_hsa052030.27337535
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.24564385
88N-Glycan biosynthesis_Homo sapiens_hsa005100.23363370
89ErbB signaling pathway_Homo sapiens_hsa040120.22593062
90FoxO signaling pathway_Homo sapiens_hsa040680.21087113
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20575689
92Complement and coagulation cascades_Homo sapiens_hsa046100.20455668
93Notch signaling pathway_Homo sapiens_hsa043300.20122872
94HIF-1 signaling pathway_Homo sapiens_hsa040660.20063407
95VEGF signaling pathway_Homo sapiens_hsa043700.16653480
96Glioma_Homo sapiens_hsa052140.16211826
97p53 signaling pathway_Homo sapiens_hsa041150.15332468
98Tryptophan metabolism_Homo sapiens_hsa003800.14672748
99Renal cell carcinoma_Homo sapiens_hsa052110.14158769
100Basal transcription factors_Homo sapiens_hsa030220.13939450

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »