

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | cellular response to growth hormone stimulus (GO:0071378) | 8.97226188 |
| 2 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 6.12801935 |
| 3 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 6.12801935 |
| 4 | modulation by symbiont of host immune response (GO:0052553) | 6.12801935 |
| 5 | positive regulation by symbiont of host defense response (GO:0052509) | 6.12801935 |
| 6 | modulation by symbiont of host defense response (GO:0052031) | 6.12801935 |
| 7 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 6.12801935 |
| 8 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 6.09509940 |
| 9 | macrophage activation involved in immune response (GO:0002281) | 6.03104102 |
| 10 | positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568) | 5.88039509 |
| 11 | T-helper 1 type immune response (GO:0042088) | 5.82115324 |
| 12 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 5.24383316 |
| 13 | detection of molecule of bacterial origin (GO:0032490) | 4.70281450 |
| 14 | regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108) | 4.61615517 |
| 15 | response to growth hormone (GO:0060416) | 4.58924164 |
| 16 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 4.42386069 |
| 17 | hydrogen peroxide biosynthetic process (GO:0050665) | 4.41858413 |
| 18 | response to host immune response (GO:0052572) | 4.37249014 |
| 19 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 4.37249014 |
| 20 | microglial cell activation (GO:0001774) | 4.30284377 |
| 21 | negative regulation of bone mineralization (GO:0030502) | 4.25669576 |
| 22 | cellular response to thyroid hormone stimulus (GO:0097067) | 4.06640158 |
| 23 | positive regulation of chemokine biosynthetic process (GO:0045080) | 3.91784214 |
| 24 | reactive oxygen species biosynthetic process (GO:1903409) | 3.87721447 |
| 25 | response to peptidoglycan (GO:0032494) | 3.84041319 |
| 26 | response to host defenses (GO:0052200) | 3.83659056 |
| 27 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.83659056 |
| 28 | response to host (GO:0075136) | 3.83659056 |
| 29 | positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517) | 3.82975802 |
| 30 | positive regulation of receptor internalization (GO:0002092) | 3.81989201 |
| 31 | regulation of interferon-alpha production (GO:0032647) | 3.81070340 |
| 32 | negative regulation of biomineral tissue development (GO:0070168) | 3.77346012 |
| 33 | regulation of vitamin D biosynthetic process (GO:0060556) | 3.75821651 |
| 34 | JAK-STAT cascade (GO:0007259) | 3.73772487 |
| 35 | regulation of T-helper 1 cell differentiation (GO:0045625) | 3.66985683 |
| 36 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.55774479 |
| 37 | response to protozoan (GO:0001562) | 3.54673052 |
| 38 | cellular response to type I interferon (GO:0071357) | 3.48624474 |
| 39 | type I interferon signaling pathway (GO:0060337) | 3.48624474 |
| 40 | regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516) | 3.44018068 |
| 41 | regulation of insulin-like growth factor receptor signaling pathway (GO:0043567) | 3.43533856 |
| 42 | response to type I interferon (GO:0034340) | 3.42567562 |
| 43 | negative regulation of interleukin-12 production (GO:0032695) | 3.41137888 |
| 44 | regulation of chemokine biosynthetic process (GO:0045073) | 3.40086857 |
| 45 | macrophage activation (GO:0042116) | 3.34834987 |
| 46 | regulation of cytokine secretion involved in immune response (GO:0002739) | 3.34498822 |
| 47 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.33597048 |
| 48 | regulation of interleukin-6 biosynthetic process (GO:0045408) | 3.33495287 |
| 49 | activation of MAPKKK activity (GO:0000185) | 3.30170651 |
| 50 | positive regulation of interferon-alpha production (GO:0032727) | 3.29200886 |
| 51 | detection of external biotic stimulus (GO:0098581) | 3.28547150 |
| 52 | positive regulation of heat generation (GO:0031652) | 3.26378397 |
| 53 | immunoglobulin mediated immune response (GO:0016064) | 3.22497863 |
| 54 | dendritic cell differentiation (GO:0097028) | 3.20759181 |
| 55 | regulation of chronic inflammatory response (GO:0002676) | 3.20390269 |
| 56 | negative regulation of viral genome replication (GO:0045071) | 3.17842373 |
| 57 | defense response to protozoan (GO:0042832) | 3.11209387 |
| 58 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 3.10353181 |
| 59 | myeloid cell activation involved in immune response (GO:0002275) | 3.06687452 |
| 60 | neutrophil activation involved in immune response (GO:0002283) | 3.05147571 |
| 61 | positive regulation of NF-kappaB import into nucleus (GO:0042346) | 3.04144320 |
| 62 | positive regulation of osteoblast proliferation (GO:0033690) | 3.02409476 |
| 63 | positive regulation of interleukin-6 production (GO:0032755) | 3.00704908 |
| 64 | positive regulation of interferon-beta production (GO:0032728) | 2.97153135 |
| 65 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 2.96751836 |
| 66 | response to thyroid hormone (GO:0097066) | 2.94492049 |
| 67 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 2.94259152 |
| 68 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 2.93229523 |
| 69 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.91378188 |
| 70 | myeloid dendritic cell differentiation (GO:0043011) | 2.88371521 |
| 71 | NIK/NF-kappaB signaling (GO:0038061) | 2.88133569 |
| 72 | branching involved in labyrinthine layer morphogenesis (GO:0060670) | 2.86067856 |
| 73 | positive regulation of cytokine biosynthetic process (GO:0042108) | 2.83883150 |
| 74 | germinal center formation (GO:0002467) | 2.82997951 |
| 75 | positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531) | 2.82966164 |
| 76 | regulation of mitochondrial membrane permeability (GO:0046902) | 2.82634030 |
| 77 | purine nucleotide salvage (GO:0032261) | 2.81925658 |
| 78 | regulation of vitamin metabolic process (GO:0030656) | 2.81772276 |
| 79 | detection of biotic stimulus (GO:0009595) | 2.79145920 |
| 80 | negative regulation of myeloid cell apoptotic process (GO:0033033) | 2.75616059 |
| 81 | regulation of B cell apoptotic process (GO:0002902) | 2.73059229 |
| 82 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.72361257 |
| 83 | T cell migration (GO:0072678) | 2.71819650 |
| 84 | superoxide anion generation (GO:0042554) | 2.71717915 |
| 85 | regulation of podosome assembly (GO:0071801) | 2.71486554 |
| 86 | negative regulation of toll-like receptor 4 signaling pathway (GO:0034144) | 2.71478665 |
| 87 | regulation of membrane permeability (GO:0090559) | 2.69058845 |
| 88 | positive regulation of interferon-gamma biosynthetic process (GO:0045078) | 2.67888655 |
| 89 | regulation of interleukin-6 production (GO:0032675) | 2.67644666 |
| 90 | negative regulation of cytokine production involved in immune response (GO:0002719) | 2.67363046 |
| 91 | regulation of fever generation (GO:0031620) | 2.66883074 |
| 92 | regulation of tyrosine phosphorylation of STAT protein (GO:0042509) | 2.59542335 |
| 93 | granulocyte differentiation (GO:0030851) | 2.58986715 |
| 94 | monocyte chemotaxis (GO:0002548) | 2.55665680 |
| 95 | regulation of mast cell degranulation (GO:0043304) | 2.55001181 |
| 96 | myeloid dendritic cell activation (GO:0001773) | 2.53804453 |
| 97 | negative regulation of interleukin-17 production (GO:0032700) | 2.48634786 |
| 98 | regulation of mast cell activation involved in immune response (GO:0033006) | 2.48038651 |
| 99 | regulation of activation of Janus kinase activity (GO:0010533) | 11.7617194 |
| 100 | growth hormone receptor signaling pathway (GO:0060396) | 10.1943685 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 5.12819233 |
| 2 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.15414449 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.63033182 |
| 4 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 3.52993253 |
| 5 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 3.28393648 |
| 6 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 3.25809868 |
| 7 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.13444061 |
| 8 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 3.06144526 |
| 9 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.00747039 |
| 10 | VDR_21846776_ChIP-Seq_THP-1_Human | 3.00602303 |
| 11 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.88395877 |
| 12 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.77798181 |
| 13 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.69708480 |
| 14 | STAT1_20625510_ChIP-Seq_HELA_Human | 2.65831986 |
| 15 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.65398040 |
| 16 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.55252430 |
| 17 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.41014995 |
| 18 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.40733851 |
| 19 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.34375084 |
| 20 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.21235860 |
| 21 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.19268917 |
| 22 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.18510770 |
| 23 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 2.13272635 |
| 24 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.12383255 |
| 25 | SPI1_23127762_ChIP-Seq_K562_Human | 2.04135075 |
| 26 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.99056933 |
| 27 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.94612952 |
| 28 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.83167940 |
| 29 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.82363920 |
| 30 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.81471184 |
| 31 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.81471184 |
| 32 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.81471184 |
| 33 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.79383304 |
| 34 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.73659733 |
| 35 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.69981518 |
| 36 | MAF_26560356_Chip-Seq_TH1_Human | 1.69939311 |
| 37 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.66627621 |
| 38 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.66421655 |
| 39 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.65457465 |
| 40 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.58793990 |
| 41 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.58156994 |
| 42 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.56564628 |
| 43 | GATA1_19941826_ChIP-Seq_K562_Human | 1.54571941 |
| 44 | UTX_26944678_Chip-Seq_JUKART_Human | 1.53178578 |
| 45 | MYB_26560356_Chip-Seq_TH2_Human | 1.52172367 |
| 46 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.46973773 |
| 47 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.44098198 |
| 48 | GATA1_22025678_ChIP-Seq_K562_Human | 1.42543492 |
| 49 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.42258269 |
| 50 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.39458500 |
| 51 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.39376977 |
| 52 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.39131068 |
| 53 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.38944907 |
| 54 | MAF_26560356_Chip-Seq_TH2_Human | 1.38240111 |
| 55 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.36570131 |
| 56 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.36547800 |
| 57 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.35078832 |
| 58 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.34515159 |
| 59 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.33489915 |
| 60 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.33053185 |
| 61 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.26609426 |
| 62 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.25184212 |
| 63 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.24953894 |
| 64 | MYB_26560356_Chip-Seq_TH1_Human | 1.24756883 |
| 65 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.23581103 |
| 66 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.23473888 |
| 67 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.19731722 |
| 68 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.19537350 |
| 69 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.19190413 |
| 70 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.18585765 |
| 71 | MYC_22102868_ChIP-Seq_BL_Human | 1.18126449 |
| 72 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.17227439 |
| 73 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.15276181 |
| 74 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.12104378 |
| 75 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.10426160 |
| 76 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.09970619 |
| 77 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.09358086 |
| 78 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.08200371 |
| 79 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.07553185 |
| 80 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.06709055 |
| 81 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.06300667 |
| 82 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.04034826 |
| 83 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.03595526 |
| 84 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.02758281 |
| 85 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.01845487 |
| 86 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 1.01794433 |
| 87 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.00346426 |
| 88 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.98540658 |
| 89 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.97811935 |
| 90 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.97676556 |
| 91 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.96259800 |
| 92 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.94880703 |
| 93 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.93226293 |
| 94 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.88457359 |
| 95 | SA1_27219007_Chip-Seq_Bcells_Human | 0.87233011 |
| 96 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.86124551 |
| 97 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.85995025 |
| 98 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.85570380 |
| 99 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.85195686 |
| 100 | GATA3_26560356_Chip-Seq_TH2_Human | 0.79594055 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005451_abnormal_body_composition | 6.48233157 |
| 2 | MP0003303_peritoneal_inflammation | 5.37864855 |
| 3 | MP0002139_abnormal_hepatobiliary_system | 3.42437755 |
| 4 | MP0003436_decreased_susceptibility_to | 3.41008547 |
| 5 | MP0002148_abnormal_hypersensitivity_rea | 3.38642776 |
| 6 | MP0009785_altered_susceptibility_to | 3.09208560 |
| 7 | MP0004510_myositis | 2.97519644 |
| 8 | MP0002132_abnormal_respiratory_system | 2.92998936 |
| 9 | MP0003724_increased_susceptibility_to | 2.92914374 |
| 10 | MP0001835_abnormal_antigen_presentation | 2.88060854 |
| 11 | MP0006082_CNS_inflammation | 2.83197027 |
| 12 | MP0005000_abnormal_immune_tolerance | 2.45066211 |
| 13 | MP0005387_immune_system_phenotype | 2.41660751 |
| 14 | MP0001790_abnormal_immune_system | 2.41660751 |
| 15 | MP0005025_abnormal_response_to | 2.36418928 |
| 16 | MP0003195_calcinosis | 2.36350919 |
| 17 | MP0008004_abnormal_stomach_pH | 2.36071650 |
| 18 | MP0005671_abnormal_response_to | 2.28763796 |
| 19 | MP0005058_abnormal_lysosome_morphology | 2.27719236 |
| 20 | MP0002723_abnormal_immune_serum | 2.22496569 |
| 21 | MP0003453_abnormal_keratinocyte_physiol | 2.18332975 |
| 22 | MP0002419_abnormal_innate_immunity | 2.17175985 |
| 23 | MP0003300_gastrointestinal_ulcer | 2.17124853 |
| 24 | MP0002452_abnormal_antigen_presenting | 2.01214761 |
| 25 | MP0001800_abnormal_humoral_immune | 2.00527481 |
| 26 | MP0000685_abnormal_immune_system | 1.99028106 |
| 27 | MP0003806_abnormal_nucleotide_metabolis | 1.82263952 |
| 28 | MP0009764_decreased_sensitivity_to | 1.76593797 |
| 29 | MP0004947_skin_inflammation | 1.75341686 |
| 30 | MP0001545_abnormal_hematopoietic_system | 1.74904617 |
| 31 | MP0005397_hematopoietic_system_phenotyp | 1.74904617 |
| 32 | MP0002420_abnormal_adaptive_immunity | 1.70319569 |
| 33 | MP0001819_abnormal_immune_cell | 1.69788504 |
| 34 | MP0000343_altered_response_to | 1.64476335 |
| 35 | MP0001845_abnormal_inflammatory_respons | 1.59188952 |
| 36 | MP0001533_abnormal_skeleton_physiology | 1.54397704 |
| 37 | MP0000678_abnormal_parathyroid_gland | 1.51895939 |
| 38 | MP0009333_abnormal_splenocyte_physiolog | 1.47957317 |
| 39 | MP0008469_abnormal_protein_level | 1.43896383 |
| 40 | MP0001853_heart_inflammation | 1.42152272 |
| 41 | MP0010155_abnormal_intestine_physiology | 1.39802079 |
| 42 | MP0003075_altered_response_to | 1.39049681 |
| 43 | MP0000767_abnormal_smooth_muscle | 1.38104505 |
| 44 | MP0009840_abnormal_foam_cell | 1.36398407 |
| 45 | MP0003828_pulmonary_edema | 1.35588340 |
| 46 | MP0000716_abnormal_immune_system | 1.35092229 |
| 47 | MP0002405_respiratory_system_inflammati | 1.34530028 |
| 48 | MP0002254_reproductive_system_inflammat | 1.31801026 |
| 49 | MP0002332_abnormal_exercise_endurance | 1.29543070 |
| 50 | MP0002398_abnormal_bone_marrow | 1.26574970 |
| 51 | MP0003448_altered_tumor_morphology | 1.21191354 |
| 52 | MP0002933_joint_inflammation | 1.19308081 |
| 53 | MP0006054_spinal_hemorrhage | 1.18251850 |
| 54 | MP0005310_abnormal_salivary_gland | 1.14147967 |
| 55 | MP0000858_altered_metastatic_potential | 1.10229656 |
| 56 | MP0002722_abnormal_immune_system | 1.09817289 |
| 57 | MP0002429_abnormal_blood_cell | 1.05115885 |
| 58 | MP0002998_abnormal_bone_remodeling | 1.04248373 |
| 59 | MP0004185_abnormal_adipocyte_glucose | 1.02887701 |
| 60 | MP0009278_abnormal_bone_marrow | 1.00495554 |
| 61 | MP0005647_abnormal_sex_gland | 0.99854389 |
| 62 | MP0000689_abnormal_spleen_morphology | 0.97602772 |
| 63 | MP0003183_abnormal_peptide_metabolism | 0.93764870 |
| 64 | MP0005166_decreased_susceptibility_to | 0.92046241 |
| 65 | MP0001663_abnormal_digestive_system | 0.92002391 |
| 66 | MP0001348_abnormal_lacrimal_gland | 0.89415009 |
| 67 | MP0001849_ear_inflammation | 0.87377292 |
| 68 | MP0010234_abnormal_vibrissa_follicle | 0.86150646 |
| 69 | MP0002837_dystrophic_cardiac_calcinosis | 0.82920084 |
| 70 | MP0001542_abnormal_bone_strength | 0.80908413 |
| 71 | MP0008874_decreased_physiological_sensi | 0.80382431 |
| 72 | MP0003221_abnormal_cardiomyocyte_apopto | 0.76835505 |
| 73 | MP0003186_abnormal_redox_activity | 0.76121614 |
| 74 | MP0009763_increased_sensitivity_to | 0.73907133 |
| 75 | MP0000703_abnormal_thymus_morphology | 0.73257447 |
| 76 | MP0010307_abnormal_tumor_latency | 0.72006149 |
| 77 | MP0000604_amyloidosis | 0.71916721 |
| 78 | MP0005464_abnormal_platelet_physiology | 0.70657039 |
| 79 | MP0005076_abnormal_cell_differentiation | 0.70172747 |
| 80 | MP0005164_abnormal_response_to | 0.69578341 |
| 81 | MP0003172_abnormal_lysosome_physiology | 0.67414097 |
| 82 | MP0003656_abnormal_erythrocyte_physiolo | 0.67026099 |
| 83 | MP0001661_extended_life_span | 0.66612000 |
| 84 | MP0002277_abnormal_respiratory_mucosa | 0.65756002 |
| 85 | MP0000490_abnormal_crypts_of | 0.65119717 |
| 86 | MP0006036_abnormal_mitochondrial_physio | 0.64200098 |
| 87 | MP0005381_digestive/alimentary_phenotyp | 0.63840845 |
| 88 | MP0001919_abnormal_reproductive_system | 0.63449197 |
| 89 | MP0003763_abnormal_thymus_physiology | 0.63047980 |
| 90 | MP0002163_abnormal_gland_morphology | 0.62419406 |
| 91 | MP0003890_abnormal_embryonic-extraembry | 0.60602742 |
| 92 | MP0008875_abnormal_xenobiotic_pharmacok | 0.60251937 |
| 93 | MP0001764_abnormal_homeostasis | 0.58772452 |
| 94 | MP0004883_abnormal_blood_vessel | 0.58480694 |
| 95 | MP0005266_abnormal_metabolism | 0.57812408 |
| 96 | MP0008872_abnormal_physiological_respon | 0.56391874 |
| 97 | MP0005390_skeleton_phenotype | 0.56253227 |
| 98 | MP0005165_increased_susceptibility_to | 0.54980786 |
| 99 | MP0001873_stomach_inflammation | 0.53719493 |
| 100 | MP0004808_abnormal_hematopoietic_stem | 0.53347430 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Short middle phalanx of the 5th finger (HP:0004220) | 6.25559068 |
| 2 | Abnormality of glycolipid metabolism (HP:0010969) | 5.26171149 |
| 3 | Abnormality of liposaccharide metabolism (HP:0010968) | 5.26171149 |
| 4 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 5.26171149 |
| 5 | Petechiae (HP:0000967) | 5.08782603 |
| 6 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 4.68074331 |
| 7 | Eczematoid dermatitis (HP:0000976) | 4.31033624 |
| 8 | Deep palmar crease (HP:0006191) | 4.23714583 |
| 9 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 4.18536065 |
| 10 | Acanthocytosis (HP:0001927) | 3.99817556 |
| 11 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 3.98911471 |
| 12 | Vacuolated lymphocytes (HP:0001922) | 3.93929670 |
| 13 | Recurrent bacterial skin infections (HP:0005406) | 3.93293092 |
| 14 | Severe short stature (HP:0003510) | 3.85085488 |
| 15 | Increased cerebral lipofuscin (HP:0011813) | 3.84342521 |
| 16 | Nuclear cataract (HP:0100018) | 3.83778750 |
| 17 | Stomatitis (HP:0010280) | 3.80503240 |
| 18 | Abnormality of macrophages (HP:0004311) | 3.62577473 |
| 19 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 3.61390305 |
| 20 | Abnormal platelet function (HP:0011869) | 3.55172154 |
| 21 | Impaired platelet aggregation (HP:0003540) | 3.55172154 |
| 22 | Mediastinal lymphadenopathy (HP:0100721) | 3.51924299 |
| 23 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.42977650 |
| 24 | Gastrointestinal stroma tumor (HP:0100723) | 3.39884158 |
| 25 | Recurrent abscess formation (HP:0002722) | 3.37701938 |
| 26 | Optic neuritis (HP:0100653) | 3.36293860 |
| 27 | Retrobulbar optic neuritis (HP:0100654) | 3.36293860 |
| 28 | Disinhibition (HP:0000734) | 3.33756931 |
| 29 | Systemic lupus erythematosus (HP:0002725) | 3.24617300 |
| 30 | Recurrent viral infections (HP:0004429) | 3.21883352 |
| 31 | Orchitis (HP:0100796) | 3.21255115 |
| 32 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.11435331 |
| 33 | Recurrent fungal infections (HP:0002841) | 3.09644412 |
| 34 | Autoimmune thrombocytopenia (HP:0001973) | 3.00564437 |
| 35 | Growth hormone deficiency (HP:0000824) | 2.95480444 |
| 36 | Myositis (HP:0100614) | 2.88247432 |
| 37 | Dysostosis multiplex (HP:0000943) | 2.83041164 |
| 38 | Vasculitis (HP:0002633) | 2.62391193 |
| 39 | Loss of speech (HP:0002371) | 2.60004594 |
| 40 | Lymphopenia (HP:0001888) | 2.55067219 |
| 41 | Mutism (HP:0002300) | 2.44819528 |
| 42 | Obstructive lung disease (HP:0006536) | 2.44676025 |
| 43 | Chronic obstructive pulmonary disease (HP:0006510) | 2.44676025 |
| 44 | Protruding tongue (HP:0010808) | 2.44585245 |
| 45 | Keratoconjunctivitis sicca (HP:0001097) | 2.42975606 |
| 46 | Prolonged bleeding time (HP:0003010) | 2.42190169 |
| 47 | Abnormality of B cell number (HP:0010975) | 2.40915779 |
| 48 | Polycythemia (HP:0001901) | 2.40789299 |
| 49 | Short 5th finger (HP:0009237) | 2.31746929 |
| 50 | B lymphocytopenia (HP:0010976) | 2.31693578 |
| 51 | Acute necrotizing encephalopathy (HP:0006965) | 2.31340205 |
| 52 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.29746275 |
| 53 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.27546542 |
| 54 | Urticaria (HP:0001025) | 2.26634804 |
| 55 | Poikilocytosis (HP:0004447) | 2.26319070 |
| 56 | Broad palm (HP:0001169) | 2.23205514 |
| 57 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.21805532 |
| 58 | Brushfield spots (HP:0001088) | 2.20932392 |
| 59 | Inappropriate behavior (HP:0000719) | 2.18243268 |
| 60 | Parakeratosis (HP:0001036) | 2.17570617 |
| 61 | Keratoconjunctivitis (HP:0001096) | 2.16079599 |
| 62 | Progressive macrocephaly (HP:0004481) | 2.11524948 |
| 63 | Axonal loss (HP:0003447) | 2.08549066 |
| 64 | Meningitis (HP:0001287) | 2.08200427 |
| 65 | Aplasia/Hypoplasia of the 5th finger (HP:0006262) | 2.07954029 |
| 66 | Glomerulonephritis (HP:0000099) | 2.04787815 |
| 67 | Recurrent skin infections (HP:0001581) | 2.02166180 |
| 68 | Pustule (HP:0200039) | 2.01395707 |
| 69 | Nausea (HP:0002018) | 2.00976872 |
| 70 | Nasal polyposis (HP:0100582) | 1.99037532 |
| 71 | Pulmonary infiltrates (HP:0002113) | 1.94221816 |
| 72 | Abnormality of dental color (HP:0011073) | 1.93827465 |
| 73 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 1.93683191 |
| 74 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 1.92692157 |
| 75 | Reticulocytosis (HP:0001923) | 1.91769234 |
| 76 | Premature skin wrinkling (HP:0100678) | 1.91074746 |
| 77 | Respiratory difficulties (HP:0002880) | 1.89912320 |
| 78 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.89329770 |
| 79 | Abnormality of the nasal mucosa (HP:0000433) | 1.88818151 |
| 80 | Mitochondrial inheritance (HP:0001427) | 1.88582873 |
| 81 | Acute encephalopathy (HP:0006846) | 1.88493352 |
| 82 | Testicular atrophy (HP:0000029) | 1.87153426 |
| 83 | Recurrent pneumonia (HP:0006532) | 1.84299466 |
| 84 | Purpura (HP:0000979) | 1.84020309 |
| 85 | Emphysema (HP:0002097) | 1.83936467 |
| 86 | T lymphocytopenia (HP:0005403) | 1.83814370 |
| 87 | Hematochezia (HP:0002573) | 1.83680040 |
| 88 | Arthralgia (HP:0002829) | 1.83649412 |
| 89 | Metaphyseal irregularity (HP:0003025) | 1.81702973 |
| 90 | Eosinophilia (HP:0001880) | 1.81367577 |
| 91 | Increased IgE level (HP:0003212) | 1.81339538 |
| 92 | Leukocytosis (HP:0001974) | 1.80683232 |
| 93 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.80310684 |
| 94 | Single umbilical artery (HP:0001195) | 1.80310684 |
| 95 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.80310684 |
| 96 | Recurrent bronchitis (HP:0002837) | 1.76416968 |
| 97 | Progressive neurologic deterioration (HP:0002344) | 1.76269493 |
| 98 | Increased CSF lactate (HP:0002490) | 1.75880150 |
| 99 | Autoimmune hemolytic anemia (HP:0001890) | 1.74465232 |
| 100 | Hepatosplenomegaly (HP:0001433) | 1.73853166 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NME2 | 4.14647297 |
| 2 | BLK | 3.89302161 |
| 3 | ARAF | 3.81475208 |
| 4 | MAP3K11 | 3.74017077 |
| 5 | MAP4K1 | 3.38748264 |
| 6 | ERN1 | 3.04093370 |
| 7 | IRAK3 | 2.87662563 |
| 8 | MAP3K1 | 2.76638167 |
| 9 | MAP3K9 | 2.76082100 |
| 10 | BRAF | 2.59974276 |
| 11 | MOS | 2.52161755 |
| 12 | PDK2 | 2.44687113 |
| 13 | MAP3K13 | 2.42429692 |
| 14 | PIM2 | 2.26529669 |
| 15 | IRAK4 | 2.22896138 |
| 16 | JAK3 | 2.14378890 |
| 17 | GRK7 | 2.14369178 |
| 18 | TAOK1 | 2.02251498 |
| 19 | TYK2 | 1.96457197 |
| 20 | TBK1 | 1.81143117 |
| 21 | STK4 | 1.78791087 |
| 22 | IKBKE | 1.77511104 |
| 23 | MATK | 1.70635363 |
| 24 | MAP3K14 | 1.70186048 |
| 25 | RIPK4 | 1.66053303 |
| 26 | KSR2 | 1.65807749 |
| 27 | CDK12 | 1.56064273 |
| 28 | ACVR1B | 1.55527138 |
| 29 | TAOK2 | 1.53466191 |
| 30 | IKBKB | 1.48639969 |
| 31 | RAF1 | 1.23794181 |
| 32 | CSK | 1.20320616 |
| 33 | TGFBR2 | 1.19824777 |
| 34 | IRAK1 | 1.11710627 |
| 35 | PIM1 | 1.10096582 |
| 36 | TXK | 1.07139122 |
| 37 | RIPK1 | 0.99936468 |
| 38 | ADRBK2 | 0.98768325 |
| 39 | DDR2 | 0.97441840 |
| 40 | CHUK | 0.97391922 |
| 41 | SYK | 0.96114068 |
| 42 | BTK | 0.93751567 |
| 43 | JAK2 | 0.89784659 |
| 44 | PRPF4B | 0.87665959 |
| 45 | LYN | 0.85589714 |
| 46 | STK10 | 0.85362637 |
| 47 | MAP3K3 | 0.84433180 |
| 48 | CDK19 | 0.82414719 |
| 49 | CSF1R | 0.81855920 |
| 50 | FGR | 0.81641100 |
| 51 | IRAK2 | 0.81533525 |
| 52 | MARK3 | 0.79985895 |
| 53 | HIPK2 | 0.77463766 |
| 54 | TEC | 0.77320006 |
| 55 | ABL2 | 0.76471211 |
| 56 | PLK4 | 0.74986743 |
| 57 | TAOK3 | 0.74510102 |
| 58 | KSR1 | 0.74013746 |
| 59 | OXSR1 | 0.72555239 |
| 60 | CDK4 | 0.67879400 |
| 61 | GRK6 | 0.66567062 |
| 62 | ZAP70 | 0.65340624 |
| 63 | DYRK3 | 0.65318398 |
| 64 | BCKDK | 0.63276511 |
| 65 | TESK2 | 0.58080735 |
| 66 | MAP3K12 | 0.56474375 |
| 67 | HCK | 0.55252914 |
| 68 | CDK8 | 0.53891545 |
| 69 | LCK | 0.53543332 |
| 70 | BRSK2 | 0.53427240 |
| 71 | MAP2K3 | 0.53376580 |
| 72 | CAMKK2 | 0.51163198 |
| 73 | ITK | 0.50802861 |
| 74 | PIK3CG | 0.50760056 |
| 75 | PDPK1 | 0.50519256 |
| 76 | FES | 0.49433950 |
| 77 | MAP3K8 | 0.49145748 |
| 78 | PAK3 | 0.48802384 |
| 79 | LRRK2 | 0.47485128 |
| 80 | MAP3K5 | 0.45106515 |
| 81 | PDK1 | 0.42771710 |
| 82 | PAK1 | 0.39048689 |
| 83 | FER | 0.38027617 |
| 84 | AKT3 | 0.36183882 |
| 85 | JAK1 | 0.34951398 |
| 86 | EIF2AK2 | 0.32394351 |
| 87 | DAPK3 | 0.31317763 |
| 88 | EPHA3 | 0.30473796 |
| 89 | PKN1 | 0.29936455 |
| 90 | MARK2 | 0.29790984 |
| 91 | PRKD1 | 0.28208212 |
| 92 | RPS6KA1 | 0.24978080 |
| 93 | PRKCI | 0.24741121 |
| 94 | KIT | 0.24052117 |
| 95 | PRKCD | 0.21419947 |
| 96 | MAPK7 | 0.18664257 |
| 97 | INSR | 0.18145366 |
| 98 | MST4 | 0.17826112 |
| 99 | MAPK4 | 0.16087897 |
| 100 | TLK1 | 0.14385083 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 3.29423221 |
| 2 | Leishmaniasis_Homo sapiens_hsa05140 | 3.11842964 |
| 3 | Allograft rejection_Homo sapiens_hsa05330 | 2.88639008 |
| 4 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.85035355 |
| 5 | Asthma_Homo sapiens_hsa05310 | 2.84360720 |
| 6 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.80254629 |
| 7 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.75329450 |
| 8 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 2.61367409 |
| 9 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.48366194 |
| 10 | Tuberculosis_Homo sapiens_hsa05152 | 2.36766199 |
| 11 | Malaria_Homo sapiens_hsa05144 | 2.35456791 |
| 12 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 2.34011958 |
| 13 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.20984892 |
| 14 | Legionellosis_Homo sapiens_hsa05134 | 2.13081050 |
| 15 | Other glycan degradation_Homo sapiens_hsa00511 | 2.12468887 |
| 16 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.04886909 |
| 17 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.01353044 |
| 18 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.87313011 |
| 19 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.86954601 |
| 20 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.83872666 |
| 21 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.80387829 |
| 22 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.74647667 |
| 23 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.74153102 |
| 24 | Influenza A_Homo sapiens_hsa05164 | 1.69475789 |
| 25 | Salmonella infection_Homo sapiens_hsa05132 | 1.62116189 |
| 26 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.62058330 |
| 27 | Lysosome_Homo sapiens_hsa04142 | 1.60549467 |
| 28 | Pertussis_Homo sapiens_hsa05133 | 1.60250884 |
| 29 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.55919466 |
| 30 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.54670034 |
| 31 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.53942058 |
| 32 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.52218442 |
| 33 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.43781005 |
| 34 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.43076673 |
| 35 | Phagosome_Homo sapiens_hsa04145 | 1.41844439 |
| 36 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.38990048 |
| 37 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.36628530 |
| 38 | Prion diseases_Homo sapiens_hsa05020 | 1.27800181 |
| 39 | Hepatitis B_Homo sapiens_hsa05161 | 1.25348085 |
| 40 | Measles_Homo sapiens_hsa05162 | 1.22129337 |
| 41 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.15303266 |
| 42 | Hepatitis C_Homo sapiens_hsa05160 | 1.13675779 |
| 43 | Bladder cancer_Homo sapiens_hsa05219 | 1.10826940 |
| 44 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.08735062 |
| 45 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.08064531 |
| 46 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.07441629 |
| 47 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.07335599 |
| 48 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.06989320 |
| 49 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.99648037 |
| 50 | Viral myocarditis_Homo sapiens_hsa05416 | 0.96257076 |
| 51 | Apoptosis_Homo sapiens_hsa04210 | 0.92163168 |
| 52 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.88152063 |
| 53 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.84691446 |
| 54 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.82961086 |
| 55 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.82244068 |
| 56 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.75080261 |
| 57 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.73664376 |
| 58 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.66156297 |
| 59 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.66066871 |
| 60 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.65891195 |
| 61 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.65309439 |
| 62 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.64344886 |
| 63 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.60874415 |
| 64 | Shigellosis_Homo sapiens_hsa05131 | 0.55373703 |
| 65 | HTLV-I infection_Homo sapiens_hsa05166 | 0.52637583 |
| 66 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.50624505 |
| 67 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.49566230 |
| 68 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.49538158 |
| 69 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.49401326 |
| 70 | Amoebiasis_Homo sapiens_hsa05146 | 0.48312960 |
| 71 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.44471327 |
| 72 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.44367201 |
| 73 | Melanoma_Homo sapiens_hsa05218 | 0.40310119 |
| 74 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.37913093 |
| 75 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.36941447 |
| 76 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.34211797 |
| 77 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.34152234 |
| 78 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.33423674 |
| 79 | Parkinsons disease_Homo sapiens_hsa05012 | 0.32764471 |
| 80 | Galactose metabolism_Homo sapiens_hsa00052 | 0.32115259 |
| 81 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.30416722 |
| 82 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.28796377 |
| 83 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.28509199 |
| 84 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.27965186 |
| 85 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.27747196 |
| 86 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.27337535 |
| 87 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.24564385 |
| 88 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.23363370 |
| 89 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.22593062 |
| 90 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.21087113 |
| 91 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.20575689 |
| 92 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.20455668 |
| 93 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.20122872 |
| 94 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.20063407 |
| 95 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.16653480 |
| 96 | Glioma_Homo sapiens_hsa05214 | 0.16211826 |
| 97 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.15332468 |
| 98 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.14672748 |
| 99 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.14158769 |
| 100 | Basal transcription factors_Homo sapiens_hsa03022 | 0.13939450 |

