UNG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcription from mitochondrial promoter (GO:0006390)8.19472435
2proline metabolic process (GO:0006560)7.59379703
3replication fork processing (GO:0031297)7.51743268
4embryonic process involved in female pregnancy (GO:0060136)7.17336269
5DNA deamination (GO:0045006)6.98104867
6DNA unwinding involved in DNA replication (GO:0006268)6.37696819
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.35771885
8positive regulation of protein homooligomerization (GO:0032464)6.33072412
9establishment of apical/basal cell polarity (GO:0035089)5.90215090
10oxidative demethylation (GO:0070989)5.81716630
11regulation of integrin activation (GO:0033623)5.76193913
12mitochondrial DNA metabolic process (GO:0032042)5.50431504
13regulation of protein homooligomerization (GO:0032462)5.38704566
14DNA strand renaturation (GO:0000733)5.38502908
15establishment of integrated proviral latency (GO:0075713)5.26533571
16establishment or maintenance of monopolar cell polarity (GO:0061339)5.09628063
17establishment of monopolar cell polarity (GO:0061162)5.09628063
18mitotic G1 DNA damage checkpoint (GO:0031571)5.07488714
19DNA replication initiation (GO:0006270)5.02297562
20viral mRNA export from host cell nucleus (GO:0046784)5.00933763
21poly(A)+ mRNA export from nucleus (GO:0016973)4.90622478
22telomere maintenance via semi-conservative replication (GO:0032201)4.66936171
23DNA replication checkpoint (GO:0000076)4.62502530
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.56564280
25G1 DNA damage checkpoint (GO:0044783)4.49194972
26formation of translation preinitiation complex (GO:0001731)4.48625732
27mitotic G1/S transition checkpoint (GO:0044819)4.46291803
28negative regulation of JAK-STAT cascade (GO:0046426)4.44788527
29mRNA cleavage (GO:0006379)4.33795814
30regulation of translational fidelity (GO:0006450)4.30405854
31negative regulation of cell cycle arrest (GO:0071157)4.29117695
32embryonic placenta development (GO:0001892)4.25622507
33DNA integration (GO:0015074)4.23646969
34negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.21499607
35chromatin remodeling at centromere (GO:0031055)4.20875014
36nucleotide-excision repair, DNA gap filling (GO:0006297)4.19370404
37spliceosomal tri-snRNP complex assembly (GO:0000244)4.17458875
38heterochromatin organization (GO:0070828)4.14353743
39CENP-A containing nucleosome assembly (GO:0034080)4.12700018
40mitotic chromosome condensation (GO:0007076)4.11659284
41establishment of viral latency (GO:0019043)4.11547173
42nuclear pore complex assembly (GO:0051292)3.98977763
43cellular response to ATP (GO:0071318)3.98775866
44double-strand break repair via nonhomologous end joining (GO:0006303)3.95998522
45non-recombinational repair (GO:0000726)3.95998522
46mitochondrial RNA metabolic process (GO:0000959)3.95455840
47glutamine family amino acid biosynthetic process (GO:0009084)3.93149393
48DNA strand elongation involved in DNA replication (GO:0006271)3.91548975
49DNA double-strand break processing (GO:0000729)3.90451244
50regulation of double-strand break repair via homologous recombination (GO:0010569)3.90326418
51histone H4-K12 acetylation (GO:0043983)3.90119863
52protein localization to kinetochore (GO:0034501)3.88125811
53IMP biosynthetic process (GO:0006188)3.85898039
54base-excision repair, AP site formation (GO:0006285)3.85864661
55negative regulation of fatty acid biosynthetic process (GO:0045717)3.83250928
56telomere maintenance via recombination (GO:0000722)3.80497811
57DNA replication-dependent nucleosome assembly (GO:0006335)3.77895558
58DNA replication-dependent nucleosome organization (GO:0034723)3.77895558
59dosage compensation (GO:0007549)3.76176497
60negative regulation of mRNA processing (GO:0050686)3.76132645
61pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.76103877
62meiotic chromosome segregation (GO:0045132)3.75632279
63positive regulation of developmental pigmentation (GO:0048087)3.75290739
64maturation of 5.8S rRNA (GO:0000460)3.74937448
65cellular response to zinc ion (GO:0071294)3.72896500
66positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.72592792
67positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.72592792
68positive regulation of mitotic sister chromatid separation (GO:1901970)3.72592792
69positive regulation of protein oligomerization (GO:0032461)3.70334381
70negative regulation of Ras GTPase activity (GO:0034261)3.69806369
71nuclear pore organization (GO:0006999)3.69454753
72DNA strand elongation (GO:0022616)3.68547542
73protein complex localization (GO:0031503)3.67713771
74regulation of sister chromatid cohesion (GO:0007063)3.67049610
75termination of RNA polymerase II transcription (GO:0006369)3.64884503
76mitotic metaphase plate congression (GO:0007080)3.63109685
77DNA replication-independent nucleosome assembly (GO:0006336)3.61426480
78DNA replication-independent nucleosome organization (GO:0034724)3.61426480
79positive regulation by host of viral transcription (GO:0043923)3.61310935
80purine nucleobase biosynthetic process (GO:0009113)3.60533801
81protein localization to chromosome, centromeric region (GO:0071459)3.59671935
82nucleobase biosynthetic process (GO:0046112)3.58695228
83L-serine metabolic process (GO:0006563)3.57770827
84kinetochore assembly (GO:0051382)3.56588925
85negative regulation of protein oligomerization (GO:0032460)3.56179410
86DNA topological change (GO:0006265)3.55429655
87regulation of RNA export from nucleus (GO:0046831)3.54807853
88folic acid-containing compound biosynthetic process (GO:0009396)3.52399831
89IMP metabolic process (GO:0046040)3.52079521
90embryonic camera-type eye development (GO:0031076)3.51942202
91regulation of gene silencing by RNA (GO:0060966)3.51078518
92regulation of posttranscriptional gene silencing (GO:0060147)3.51078518
93regulation of gene silencing by miRNA (GO:0060964)3.51078518
94regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.48891112
95* base-excision repair (GO:0006284)3.48747247
96regulation of double-strand break repair (GO:2000779)3.48495795
97mitotic sister chromatid cohesion (GO:0007064)3.47046906
98face development (GO:0060324)3.46206387
99DNA ligation (GO:0006266)3.45547472
100convergent extension (GO:0060026)3.44880155
101trophectodermal cell differentiation (GO:0001829)3.44280339
102regulation of protein oligomerization (GO:0032459)3.43455921
103negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.41670489
104ribosome assembly (GO:0042255)3.40703680
105positive regulation of DNA repair (GO:0045739)3.39392563
106histone exchange (GO:0043486)3.39178689
107apoptotic process involved in morphogenesis (GO:0060561)3.38077328
108histone arginine methylation (GO:0034969)3.36035014
109GDP-mannose metabolic process (GO:0019673)3.34121751
110peptidyl-arginine omega-N-methylation (GO:0035247)3.32415105
111negative regulation of RNA splicing (GO:0033119)3.32253070
112regulation of DNA damage checkpoint (GO:2000001)3.28422601
113DNA duplex unwinding (GO:0032508)3.27295657
114mitochondrial DNA replication (GO:0006264)3.24773900
115nodal signaling pathway (GO:0038092)3.23961710
116mitotic recombination (GO:0006312)3.23934053
117chromatin assembly or disassembly (GO:0006333)3.23773715
118telomere maintenance via telomere lengthening (GO:0010833)3.23537481
119mitotic nuclear envelope disassembly (GO:0007077)3.23057592
120DNA demethylation (GO:0080111)3.21828003
121regulation of helicase activity (GO:0051095)3.20160087
122glial cell migration (GO:0008347)3.18805018
123DNA geometric change (GO:0032392)3.17029233
124labyrinthine layer development (GO:0060711)3.16804281
125sister chromatid segregation (GO:0000819)3.15623776
126positive regulation of chromosome segregation (GO:0051984)3.14321482
127anatomical structure regression (GO:0060033)3.13233088
128cellular protein complex localization (GO:0034629)3.13194007
129resolution of meiotic recombination intermediates (GO:0000712)3.13046883
130transcription-coupled nucleotide-excision repair (GO:0006283)3.12832073
131regulation of mitochondrial translation (GO:0070129)3.12343060
132ATP-dependent chromatin remodeling (GO:0043044)3.09767014
133pyrimidine nucleotide catabolic process (GO:0006244)3.06684331
134nuclear envelope reassembly (GO:0031468)3.06524442
135mitotic nuclear envelope reassembly (GO:0007084)3.06524442
136ribosomal small subunit assembly (GO:0000028)3.06516745
137pore complex assembly (GO:0046931)3.06384491
138spliceosomal snRNP assembly (GO:0000387)3.05112376
139telomere maintenance (GO:0000723)3.03059867
140telomere organization (GO:0032200)3.03009301
141chromatin assembly (GO:0031497)3.02809625
142regulation of centriole replication (GO:0046599)3.02305724
143metaphase plate congression (GO:0051310)3.02129653
144kinetochore organization (GO:0051383)2.98682434
145translesion synthesis (GO:0019985)2.98367156
146negative regulation of mRNA metabolic process (GO:1903312)2.97885965
147nuclear envelope disassembly (GO:0051081)2.96857754
148membrane disassembly (GO:0030397)2.96857754
149mitotic sister chromatid segregation (GO:0000070)2.96019281
150* somatic hypermutation of immunoglobulin genes (GO:0016446)2.95409742
151* somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95409742
152determination of adult lifespan (GO:0008340)2.95365673
153G1/S transition of mitotic cell cycle (GO:0000082)2.91802214
154cell cycle G1/S phase transition (GO:0044843)2.91802214
155ribosome biogenesis (GO:0042254)2.91429382
156mRNA export from nucleus (GO:0006406)2.91100174
157maturation of SSU-rRNA (GO:0030490)2.90521933
158DNA replication (GO:0006260)2.90404002
159deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.88233148
160negative regulation of chromosome segregation (GO:0051985)2.83772338
161DNA conformation change (GO:0071103)2.80068230
162peptidyl-arginine N-methylation (GO:0035246)2.79872780
163peptidyl-arginine methylation (GO:0018216)2.79872780
164DNA damage response, detection of DNA damage (GO:0042769)2.78390008
165DNA synthesis involved in DNA repair (GO:0000731)2.77769298
166regulation of chromosome segregation (GO:0051983)2.77671283
167negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77423213
168proteasome assembly (GO:0043248)2.76221807
169postreplication repair (GO:0006301)2.76210183
170DNA catabolic process, exonucleolytic (GO:0000738)2.75393687
171pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.74297395
172ribonucleoprotein complex biogenesis (GO:0022613)2.73827235
173negative regulation of sister chromatid segregation (GO:0033046)2.73058106
174negative regulation of mitotic sister chromatid segregation (GO:0033048)2.73058106
175proline biosynthetic process (GO:0006561)10.0568762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.09326373
2SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.35874326
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20961947
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.20287990
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.11692474
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.11692474
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.11692474
8* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.84120407
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63957225
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61204976
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55634482
12AR_21909140_ChIP-Seq_LNCAP_Human2.52048945
13* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.51160022
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.37989872
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.37680285
16SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.35371839
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32854156
18VDR_21846776_ChIP-Seq_THP-1_Human2.30043646
19NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.29257304
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.29236253
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.21789085
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.20435163
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.17164756
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16503590
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09203903
26* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.06590912
27POU5F1_16518401_ChIP-PET_MESCs_Mouse2.04764439
28TCF3_18692474_ChIP-Seq_MESCs_Mouse2.02155679
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.99715235
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96806413
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.93181426
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88611668
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86425641
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83735115
35TCF3_18692474_ChIP-Seq_MEFs_Mouse1.83246343
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.82336242
37NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.81558754
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80981591
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.77048101
40NANOG_21062744_ChIP-ChIP_HESCs_Human1.73239980
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72206137
42FOXP3_21729870_ChIP-Seq_TREG_Human1.69400734
43MYC_22102868_ChIP-Seq_BL_Human1.68756555
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68073014
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.66160186
46PU.1_20513432_ChIP-Seq_Bcells_Mouse1.63546890
47ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.63241198
48LXR_22292898_ChIP-Seq_THP-1_Human1.62674174
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62547718
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60271125
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58757308
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.54984346
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.54523384
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54270784
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.54145795
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51805505
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.51286575
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.50618608
59NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.49238190
60NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.47347949
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46331699
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46171150
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45431009
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43764735
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43488952
66VDR_23849224_ChIP-Seq_CD4+_Human1.42778169
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41967681
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.39443014
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38350744
70* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.37798512
71GABP_19822575_ChIP-Seq_HepG2_Human1.37481985
72* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.36067143
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34859630
74ZNF263_19887448_ChIP-Seq_K562_Human1.34642242
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32182035
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31866199
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31522800
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31305414
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29620776
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.29426835
81DCP1A_22483619_ChIP-Seq_HELA_Human1.28764359
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27259339
83* ELK1_19687146_ChIP-ChIP_HELA_Human1.25913856
84* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25524555
85NANOG_18692474_ChIP-Seq_MESCs_Mouse1.24400579
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24192221
87RACK7_27058665_Chip-Seq_MCF-7_Human1.23393840
88* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.23241102
89KDM5A_27292631_Chip-Seq_BREAST_Human1.22990955
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22550920
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22468284
92XRN2_22483619_ChIP-Seq_HELA_Human1.22238532
93* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21951739
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21584493
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21233517
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19843021
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19825162
98ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19689522
99ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19673981
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19638571
101* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19533922
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17651666
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17060584
104TTF2_22483619_ChIP-Seq_HELA_Human1.16701192
105ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16289061
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13656037
107* E2F1_21310950_ChIP-Seq_MCF-7_Human1.13507986
108* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12369153
109ETS1_21867929_ChIP-Seq_TH2_Mouse1.12091070
110* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11252515
111* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11019376
112SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10667181
113RARB_24833708_ChIP-Seq_LIVER_Mouse1.10242188
114TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10206185
115* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09561604
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.05572215
117PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.05507884
118MYC_18940864_ChIP-ChIP_HL60_Human1.04184507
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02721030
120KDM2B_26808549_Chip-Seq_DND41_Human1.02648056
121KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02077725
122NANOG_18692474_ChIP-Seq_MEFs_Mouse1.00065156
123CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99926007
124KAP1_27257070_Chip-Seq_ESCs_Mouse0.99382651
125EST1_17652178_ChIP-ChIP_JURKAT_Human0.99194965
126NANOG_16153702_ChIP-ChIP_HESCs_Human0.98872907
127RARA_24833708_ChIP-Seq_LIVER_Mouse0.98212077
128TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97729695
129CIITA_25753668_ChIP-Seq_RAJI_Human0.97662213
130SOX2_16153702_ChIP-ChIP_HESCs_Human0.97556445
131EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97528596
132SPI1_26923725_Chip-Seq_HPCs_Mouse0.97322643
133SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97237703
134SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92748568
135* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91780880
136SOX17_20123909_ChIP-Seq_XEN_Mouse0.91262892
137ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90053583
138TP63_19390658_ChIP-ChIP_HaCaT_Human0.89227544
139SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87313934
140RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84833483
141CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82541526
142SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82012177
143HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79593071
144PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.79049697
145* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78839175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.56685115
2MP0005171_absent_coat_pigmentation4.19051770
3MP0009278_abnormal_bone_marrow4.18183458
4MP0010030_abnormal_orbit_morphology3.60071196
5MP0004233_abnormal_muscle_weight3.13909295
6MP0010094_abnormal_chromosome_stability3.11998748
7MP0002009_preneoplasia3.01542209
8MP0008995_early_reproductive_senescence2.56792666
9MP0004957_abnormal_blastocyst_morpholog2.51766930
10MP0003890_abnormal_embryonic-extraembry2.48279013
11MP0003786_premature_aging2.25313565
12MP0003111_abnormal_nucleus_morphology2.25203144
13MP0005397_hematopoietic_system_phenotyp2.22930531
14MP0001545_abnormal_hematopoietic_system2.22930531
15MP0008058_abnormal_DNA_repair2.15205355
16MP0004133_heterotaxia2.10687279
17MP0008877_abnormal_DNA_methylation2.05846218
18MP0003283_abnormal_digestive_organ2.05816522
19MP0002653_abnormal_ependyma_morphology2.03936929
20MP0009672_abnormal_birth_weight2.02787140
21MP0003119_abnormal_digestive_system1.99338672
22MP0005174_abnormal_tail_pigmentation1.95570283
23MP0006292_abnormal_olfactory_placode1.94541647
24MP0003693_abnormal_embryo_hatching1.90994568
25MP0006072_abnormal_retinal_apoptosis1.85926149
26MP0002249_abnormal_larynx_morphology1.84604048
27MP0003077_abnormal_cell_cycle1.80262227
28MP0008932_abnormal_embryonic_tissue1.79387366
29MP0010352_gastrointestinal_tract_polyps1.78063239
30MP0002086_abnormal_extraembryonic_tissu1.70417764
31MP0005076_abnormal_cell_differentiation1.70195773
32MP0001293_anophthalmia1.69473912
33MP0002084_abnormal_developmental_patter1.68305752
34MP0001697_abnormal_embryo_size1.66108336
35MP0009697_abnormal_copulation1.65466315
36MP0003453_abnormal_keratinocyte_physiol1.63543870
37MP0000537_abnormal_urethra_morphology1.60582719
38MP0002085_abnormal_embryonic_tissue1.58195128
39MP0003567_abnormal_fetal_cardiomyocyte1.58009134
40MP0002282_abnormal_trachea_morphology1.57071529
41MP0000490_abnormal_crypts_of1.54972246
42MP0004197_abnormal_fetal_growth/weight/1.51648919
43MP0000579_abnormal_nail_morphology1.47421582
44MP0005380_embryogenesis_phenotype1.43590291
45MP0001672_abnormal_embryogenesis/_devel1.43590291
46MP0001346_abnormal_lacrimal_gland1.43270201
47MP0000566_synostosis1.42160131
48MP0005075_abnormal_melanosome_morpholog1.41327853
49MP0000350_abnormal_cell_proliferation1.37692579
50MP0003315_abnormal_perineum_morphology1.37073886
51MP0003806_abnormal_nucleotide_metabolis1.36310639
52MP0003123_paternal_imprinting1.33889419
53MP0000371_diluted_coat_color1.32842700
54MP0002697_abnormal_eye_size1.32519048
55MP0003937_abnormal_limbs/digits/tail_de1.31684113
56MP0006035_abnormal_mitochondrial_morpho1.31657395
57MP0001730_embryonic_growth_arrest1.31123890
58MP0004185_abnormal_adipocyte_glucose1.28842458
59MP0000015_abnormal_ear_pigmentation1.28174004
60MP0003718_maternal_effect1.26334805
61MP0000470_abnormal_stomach_morphology1.25356744
62MP0002269_muscular_atrophy1.23827406
63MP0002111_abnormal_tail_morphology1.17386700
64MP0003172_abnormal_lysosome_physiology1.15945467
65MP0000462_abnormal_digestive_system1.12160867
66MP0002080_prenatal_lethality1.12031105
67MP0003984_embryonic_growth_retardation1.11251195
68MP0002234_abnormal_pharynx_morphology1.07661218
69MP0002088_abnormal_embryonic_growth/wei1.06228785
70MP0000358_abnormal_cell_content/1.04128963
71MP0000639_abnormal_adrenal_gland1.03162641
72MP0003828_pulmonary_edema1.02601739
73MP0009703_decreased_birth_body1.02021353
74MP0004264_abnormal_extraembryonic_tissu1.00908256
75MP0008789_abnormal_olfactory_epithelium1.00589526
76MP0003121_genomic_imprinting1.00445259
77MP0002796_impaired_skin_barrier1.00270235
78MP0001929_abnormal_gametogenesis0.99600441
79* MP0002019_abnormal_tumor_incidence0.98886849
80MP0001340_abnormal_eyelid_morphology0.98740199
81MP0010307_abnormal_tumor_latency0.97980203
82MP0005058_abnormal_lysosome_morphology0.96840433
83MP0002233_abnormal_nose_morphology0.96438658
84MP0000049_abnormal_middle_ear0.95221471
85MP0005266_abnormal_metabolism0.94372543
86MP0002075_abnormal_coat/hair_pigmentati0.94245723
87MP0002160_abnormal_reproductive_system0.93071698
88MP0002932_abnormal_joint_morphology0.92650122
89MP0000762_abnormal_tongue_morphology0.91248628
90MP0001529_abnormal_vocalization0.91171149
91MP0001286_abnormal_eye_development0.91084051
92MP0003186_abnormal_redox_activity0.90287257
93MP0006036_abnormal_mitochondrial_physio0.89528081
94MP0005499_abnormal_olfactory_system0.89339015
95MP0005394_taste/olfaction_phenotype0.89339015
96MP0002092_abnormal_eye_morphology0.88948670
97MP0003935_abnormal_craniofacial_develop0.87098165
98MP0003755_abnormal_palate_morphology0.87053892
99MP0002114_abnormal_axial_skeleton0.86129102
100MP0001145_abnormal_male_reproductive0.85779246
101MP0001188_hyperpigmentation0.85225495
102MP0002938_white_spotting0.84821564
103MP0001661_extended_life_span0.83423582
104MP0004147_increased_porphyrin_level0.83290111
105MP0002254_reproductive_system_inflammat0.82808262
106MP0003861_abnormal_nervous_system0.82605117
107MP0001186_pigmentation_phenotype0.78644663
108MP0003137_abnormal_impulse_conducting0.77346865
109* MP0000313_abnormal_cell_death0.77235499
110MP0002163_abnormal_gland_morphology0.76860142
111MP0002116_abnormal_craniofacial_bone0.75190604
112MP0000428_abnormal_craniofacial_morphol0.75148895
113MP0009115_abnormal_fat_cell0.74820406
114MP0000432_abnormal_head_morphology0.74714265
115MP0005501_abnormal_skin_physiology0.74711989
116MP0005384_cellular_phenotype0.74323399
117MP0009053_abnormal_anal_canal0.73307262
118MP0003941_abnormal_skin_development0.72978966
119MP0009333_abnormal_splenocyte_physiolog0.71315052
120MP0001727_abnormal_embryo_implantation0.71289878
121MP0005330_cardiomyopathy0.71035797
122MP0002210_abnormal_sex_determination0.70524900
123MP0003136_yellow_coat_color0.70384595
124MP0002396_abnormal_hematopoietic_system0.69799977
125MP0005085_abnormal_gallbladder_physiolo0.68621332
126MP0001881_abnormal_mammary_gland0.66257807
127MP0002161_abnormal_fertility/fecundity0.66066031
128MP0002060_abnormal_skin_morphology0.65863859
129MP0001119_abnormal_female_reproductive0.65522898
130MP0010630_abnormal_cardiac_muscle0.65232495
131MP0002877_abnormal_melanocyte_morpholog0.64990977
132MP0002332_abnormal_exercise_endurance0.64578789
133MP0001324_abnormal_eye_pigmentation0.64487350
134MP0003698_abnormal_male_reproductive0.63811203
135MP0000653_abnormal_sex_gland0.63489910
136MP0003221_abnormal_cardiomyocyte_apopto0.63309991
137MP0000467_abnormal_esophagus_morphology0.63117111
138MP0000685_abnormal_immune_system0.62688893
139MP0000516_abnormal_urinary_system0.62605301
140MP0005367_renal/urinary_system_phenotyp0.62605301
141MP0003936_abnormal_reproductive_system0.61971291
142MP0003943_abnormal_hepatobiliary_system0.61516056
143MP0002405_respiratory_system_inflammati0.61447042
144MP0003699_abnormal_female_reproductive0.60983035
145MP0000477_abnormal_intestine_morphology0.60067996
146MP0010234_abnormal_vibrissa_follicle0.59598264
147MP0008007_abnormal_cellular_replicative0.59181693
148MP0005621_abnormal_cell_physiology0.59094048
149MP0000678_abnormal_parathyroid_gland0.57664975
150MP0001849_ear_inflammation0.57588466
151MP0009379_abnormal_foot_pigmentation0.57094238
152MP0003942_abnormal_urinary_system0.57043435

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.77430521
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.39301684
3Concave nail (HP:0001598)5.24457817
4Facial hemangioma (HP:0000329)5.20096491
5Rectal fistula (HP:0100590)5.07496461
6Rectovaginal fistula (HP:0000143)5.07496461
7Annular pancreas (HP:0001734)5.01293986
8Pustule (HP:0200039)5.01290458
9Chromsome breakage (HP:0040012)4.88237002
10Intestinal fistula (HP:0100819)4.60256314
11Poikiloderma (HP:0001029)4.55534673
12Vaginal fistula (HP:0004320)4.46480521
13Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.40476049
14Alopecia of scalp (HP:0002293)4.34988755
15Turricephaly (HP:0000262)4.20068333
16Hypochromic microcytic anemia (HP:0004840)4.17565105
17Ulnar bowing (HP:0003031)4.06383467
18Tongue fasciculations (HP:0001308)4.02446092
19Short humerus (HP:0005792)3.89789581
20Birth length less than 3rd percentile (HP:0003561)3.86278541
21Aplasia/hypoplasia of the humerus (HP:0006507)3.86082645
22Absent radius (HP:0003974)3.69571798
23Muscle fibrillation (HP:0010546)3.69234674
24Male infertility (HP:0003251)3.67648207
25Intestinal atresia (HP:0011100)3.64170737
26Coronal craniosynostosis (HP:0004440)3.63548746
27Abnormal hemoglobin (HP:0011902)3.56158519
28Colon cancer (HP:0003003)3.51830639
29Reticulocytopenia (HP:0001896)3.50063364
30Absent forearm bone (HP:0003953)3.47542221
31Aplasia involving forearm bones (HP:0009822)3.47542221
32Meckel diverticulum (HP:0002245)3.46723641
33Orthostatic hypotension (HP:0001278)3.44603459
34Absent thumb (HP:0009777)3.29211273
35Anteriorly placed anus (HP:0001545)3.27503016
36Abnormality of the preputium (HP:0100587)3.22107887
37Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.21556066
38Vertebral hypoplasia (HP:0008417)3.21556066
39Multiple enchondromatosis (HP:0005701)3.20820489
40Microvesicular hepatic steatosis (HP:0001414)3.20465697
41Squamous cell carcinoma (HP:0002860)3.18647845
42Patellar aplasia (HP:0006443)3.16244081
43Short chin (HP:0000331)3.11559923
44Aplasia/Hypoplasia of the uvula (HP:0010293)3.09517814
45Congenital hip dislocation (HP:0001374)3.05049375
46Basal cell carcinoma (HP:0002671)3.04660237
47Broad alveolar ridges (HP:0000187)3.04616901
48Alacrima (HP:0000522)3.01143136
49Selective tooth agenesis (HP:0001592)2.96101652
50Abnormality of chromosome stability (HP:0003220)2.94474187
51Abnormality of the aortic arch (HP:0012303)2.93622769
52Aplasia/Hypoplasia of the patella (HP:0006498)2.91487381
53Premature graying of hair (HP:0002216)2.84224576
54Premature skin wrinkling (HP:0100678)2.83617178
55Dysautonomia (HP:0002459)2.83311611
56Volvulus (HP:0002580)2.82598641
57Large for gestational age (HP:0001520)2.81953852
58Albinism (HP:0001022)2.80028101
59Medulloblastoma (HP:0002885)2.77837255
60Pancreatic islet-cell hyperplasia (HP:0004510)2.73327055
61Abnormality of the labia minora (HP:0012880)2.73119848
62Capillary hemangiomas (HP:0005306)2.69360997
63Mucopolysacchariduria (HP:0008155)2.66300830
64Urinary glycosaminoglycan excretion (HP:0003541)2.66300830
65Hypotrichosis (HP:0001006)2.66145081
66Diaphragmatic weakness (HP:0009113)2.64660323
67Progressive muscle weakness (HP:0003323)2.64145763
68Increased nuchal translucency (HP:0010880)2.59589838
69Hamartoma (HP:0010566)2.56842762
70Choanal stenosis (HP:0000452)2.52363280
71Hypochromic anemia (HP:0001931)2.52324556
72Nephroblastoma (Wilms tumor) (HP:0002667)2.49302366
73Bifid uvula (HP:0000193)2.49212001
74Aplasia of the musculature (HP:0100854)2.49151049
75Aplasia/Hypoplasia of the sacrum (HP:0008517)2.46366940
76Hypotelorism (HP:0000601)2.44266814
77Cortical dysplasia (HP:0002539)2.43677893
78Astrocytoma (HP:0009592)2.42628860
79Abnormality of the astrocytes (HP:0100707)2.42628860
80Acute lymphatic leukemia (HP:0006721)2.42009288
81Joint stiffness (HP:0001387)2.39314830
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.38525733
83Abnormality of polysaccharide metabolism (HP:0011012)2.38525733
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.38525733
85Small intestinal stenosis (HP:0012848)2.38104371
86Duodenal stenosis (HP:0100867)2.38104371
87Horseshoe kidney (HP:0000085)2.37013762
88Abnormality of the carotid arteries (HP:0005344)2.36927805
89Vertebral fusion (HP:0002948)2.34208719
90Hypoplasia of the radius (HP:0002984)2.34096390
91Decreased lacrimation (HP:0000633)2.30850833
92Embryonal renal neoplasm (HP:0011794)2.30713741
93Facial cleft (HP:0002006)2.30678280
94Triphalangeal thumb (HP:0001199)2.30248570
95Dysostosis multiplex (HP:0000943)2.29354936
96Abnormal lung lobation (HP:0002101)2.27944149
97Increased number of teeth (HP:0011069)2.27787820
98Hypokinesia (HP:0002375)2.26522481
99Gastrointestinal atresia (HP:0002589)2.25440536
100Abnormality of glycolysis (HP:0004366)2.25242304
101Growth hormone excess (HP:0000845)2.24820934
102Bowing of the arm (HP:0006488)2.24053310
103Bowed forearm bones (HP:0003956)2.24053310
104Spastic diplegia (HP:0001264)2.23357388
105Abnormality of cells of the erythroid lineage (HP:0012130)2.22528194
106Duplication of thumb phalanx (HP:0009942)2.21712338
107Polycythemia (HP:0001901)2.20267767
108Neoplasm of the oral cavity (HP:0100649)2.20222523
109Clumsiness (HP:0002312)2.19814248
110Abnormality of cochlea (HP:0000375)2.19067300
111Proximal placement of thumb (HP:0009623)2.18336495
112Split hand (HP:0001171)2.15625523
113Abnormal number of erythroid precursors (HP:0012131)2.14717802
114Muscle fiber atrophy (HP:0100295)2.12539075
115Hyperglycinemia (HP:0002154)2.11666059
116Hyperglycinuria (HP:0003108)2.11615041
117Microglossia (HP:0000171)2.10534352
118Increased serum pyruvate (HP:0003542)2.10202342
119Amelogenesis imperfecta (HP:0000705)2.10173325
120High anterior hairline (HP:0009890)2.10065362
121Rhabdomyosarcoma (HP:0002859)2.09395425
122Redundant skin (HP:0001582)2.07411722
123Deviation of the thumb (HP:0009603)2.07408815
124Breast hypoplasia (HP:0003187)2.07221010
125Abnormal number of incisors (HP:0011064)2.07168246
126Popliteal pterygium (HP:0009756)2.07092093
127Myelodysplasia (HP:0002863)2.06201532
128Abnormality of the duodenum (HP:0002246)2.05048923
129Abnormality of the ileum (HP:0001549)2.04297416
130Spinal muscular atrophy (HP:0007269)2.03717846
131Hypoplasia of the ulna (HP:0003022)2.01992660
132Ectopic kidney (HP:0000086)2.00860216
133Narrow nasal bridge (HP:0000446)1.99754619
134Cerebral aneurysm (HP:0004944)1.99679932
135Shoulder girdle muscle weakness (HP:0003547)1.99514750
136Type 2 muscle fiber atrophy (HP:0003554)1.98573344
137Type I transferrin isoform profile (HP:0003642)1.96701058
138Aplasia/Hypoplasia involving the musculature (HP:0001460)1.95727968
139Bulbar palsy (HP:0001283)1.94880854
140Short 5th finger (HP:0009237)1.94135450
141Short thumb (HP:0009778)1.93249955
142Ependymoma (HP:0002888)1.93019272
143Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92750661
144Choanal atresia (HP:0000453)1.92006804
145Lipid accumulation in hepatocytes (HP:0006561)1.91846946
146Increased hepatocellular lipid droplets (HP:0006565)1.90997512
147Glioma (HP:0009733)1.90534392
148Carpal bone hypoplasia (HP:0001498)1.90504161
149Impulsivity (HP:0100710)1.90200523
150Premature ovarian failure (HP:0008209)1.89838956
151Macrocytic anemia (HP:0001972)1.89633942
152Secondary amenorrhea (HP:0000869)1.87670658
153Exertional dyspnea (HP:0002875)1.87212481
154Atresia of the external auditory canal (HP:0000413)1.86744500
155Abnormality of serine family amino acid metabolism (HP:0010894)1.85696945
156Abnormality of glycine metabolism (HP:0010895)1.85696945
157Postnatal microcephaly (HP:0005484)1.82260530
158Gout (HP:0001997)1.82230081
159Cleft eyelid (HP:0000625)1.82035714
160Pancytopenia (HP:0001876)1.81987209
161Ragged-red muscle fibers (HP:0003200)1.81455643
162Reduced antithrombin III activity (HP:0001976)1.81024169
163Neoplasm of the colon (HP:0100273)1.80133227
164Sloping forehead (HP:0000340)1.77504644
165Abnormal mitochondria in muscle tissue (HP:0008316)1.76144089
166Acute encephalopathy (HP:0006846)1.76052822
167Increased serum lactate (HP:0002151)1.73320414
168Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.69185635
169Decreased activity of mitochondrial respiratory chain (HP:0008972)1.69185635
170Tracheoesophageal fistula (HP:0002575)1.67435903
171Overriding aorta (HP:0002623)1.67014192
172Embryonal neoplasm (HP:0002898)1.66968198
173Irregular epiphyses (HP:0010582)1.65188569
174Degeneration of anterior horn cells (HP:0002398)1.64674270
175Abnormality of the anterior horn cell (HP:0006802)1.64674270
176Neoplasm of the pancreas (HP:0002894)1.64531240
177Megaloblastic anemia (HP:0001889)1.63635160
178Abnormal protein N-linked glycosylation (HP:0012347)1.62699994
179Abnormal protein glycosylation (HP:0012346)1.62699994
180Abnormal glycosylation (HP:0012345)1.62699994
181Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.62699994
182Cerebral edema (HP:0002181)1.61064226
183Broad distal phalanx of finger (HP:0009836)1.60886311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.93542696
2MAPK155.11749761
3DDR24.83384999
4MAP3K64.72114587
5VRK24.15386201
6SRPK13.47081966
7MAP3K113.45236408
8PINK13.25210175
9MATK2.93885525
10PBK2.89253632
11TYRO32.84562092
12FGR2.80826463
13TSSK62.61454243
14SMG12.56189855
15DAPK12.52603663
16TAF12.31567897
17NME22.27965317
18PIM22.25831291
19UHMK12.24680077
20PLK42.15700793
21YES12.13406551
22BMX2.12827867
23PRKD22.12686378
24CSK2.06907254
25CDK72.03359209
26DYRK1B1.88272715
27SCYL21.86772466
28PDGFRA1.86517295
29PLK31.79286136
30VRK11.77103272
31BCKDK1.73134886
32AKT31.72969204
33MKNK11.68580046
34ZAK1.65959606
35EIF2AK11.51508895
36PIM11.49404075
37LATS21.48058995
38CDK61.42161041
39TRIM281.41362710
40TRPM71.35534598
41EEF2K1.32980784
42CHEK21.32730354
43BRSK11.31973476
44STK161.25404748
45RPS6KC11.25264427
46RPS6KL11.25264427
47NME11.20594183
48TESK21.19826230
49KDR1.15159150
50MAPK111.13331464
51PASK1.13274993
52CDK191.12952805
53PLK11.12595536
54CDC42BPA1.10714502
55DYRK31.10515678
56RPS6KA61.08744427
57MST41.06221212
58WEE11.05029574
59NUAK11.03899122
60GSK3A1.01315981
61CDC70.94605184
62PHKG20.93911666
63PHKG10.93911666
64MAP3K100.92030113
65CSNK1G30.87842855
66RPS6KA40.83779680
67CDK120.83533299
68BUB10.82158025
69ATR0.81492535
70EIF2AK30.79582314
71TAOK20.79560701
72RPS6KB20.78705033
73PRPF4B0.77734219
74EPHA20.76330727
75NEK20.73099558
76MTOR0.72521387
77EIF2AK20.70794498
78ARAF0.69517031
79STK40.69405114
80RPS6KA10.68393303
81BRAF0.67773232
82HIPK20.67339648
83CSNK1A1L0.66670743
84PRKAA10.64482547
85CSNK1G20.64074125
86BRD40.59042721
87CDK90.58122590
88RAF10.57379656
89* CDK20.55856183
90ERBB40.55842649
91AKT20.55347895
92AURKA0.53181003
93CSNK2A10.52092891
94TESK10.48885580
95CHEK10.48801434
96PDK20.48207144
97PRKDC0.47069862
98CDK11A0.46565225
99CSNK1E0.46315938
100TTK0.45419226
101NEK10.45112490
102ATM0.43107527
103CDK180.42931277
104CDK150.42652125
105AURKB0.42622442
106STK30.42350785
107MET0.41823636
108RPS6KB10.41379825
109CDK40.41194466
110PNCK0.39261191
111BCR0.39180727
112CDK140.39158293
113CSNK2A20.39150257
114LYN0.38621170
115DYRK20.38244507
116EGFR0.38120800
117FGFR10.37352704
118LIMK10.36835889
119CCNB10.36783112
120ERBB30.36020222
121MAPK30.34130675
122CDK80.33912212
123CSNK1G10.33815216
124MELK0.33791969
125MAPKAPK50.33456394
126ALK0.32899568
127MAPKAPK30.32548179
128LATS10.32140888
129CAMK2G0.31122277
130MAPK40.29974769
131CLK10.29784203
132MAPK100.29536899
133CAMK2B0.29209009
134* MAPK10.28793782
135TAOK10.28295116
136* CDK10.27678623
137ACVR1B0.26282255
138* MAPK140.26142059
139STK38L0.25362835
140PDGFRB0.25021656
141PRKAA20.24062103
142BRSK20.22930938
143TNK20.21345990
144MAPKAPK20.21258715
145MAP3K90.18499601
146AKT10.17048189
147PAK10.16500197
148INSR0.16482885
149FLT30.16301243
150MAP3K80.16287966
151PAK40.15835363
152MKNK20.15311848
153PRKCI0.15284707
154TLK10.15138285
155PAK20.14325450
156STK380.13705872

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.61934691
2DNA replication_Homo sapiens_hsa030304.76461469
3Fatty acid biosynthesis_Homo sapiens_hsa000614.74486207
4* Base excision repair_Homo sapiens_hsa034103.72912806
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85334017
6Nucleotide excision repair_Homo sapiens_hsa034202.77887257
7Spliceosome_Homo sapiens_hsa030402.55625670
8Homologous recombination_Homo sapiens_hsa034402.50124632
9RNA transport_Homo sapiens_hsa030132.41981684
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.26246583
11Fanconi anemia pathway_Homo sapiens_hsa034602.16901530
12mRNA surveillance pathway_Homo sapiens_hsa030152.09222181
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.88178004
14Cell cycle_Homo sapiens_hsa041101.86156846
15Notch signaling pathway_Homo sapiens_hsa043301.80379750
16Arginine and proline metabolism_Homo sapiens_hsa003301.80187691
17Circadian rhythm_Homo sapiens_hsa047101.79869994
18p53 signaling pathway_Homo sapiens_hsa041151.79750589
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76442268
20mTOR signaling pathway_Homo sapiens_hsa041501.74911676
21Hippo signaling pathway_Homo sapiens_hsa043901.72338205
22Hedgehog signaling pathway_Homo sapiens_hsa043401.70811693
23Biosynthesis of amino acids_Homo sapiens_hsa012301.61558410
24Sulfur relay system_Homo sapiens_hsa041221.59858073
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.56208294
26Folate biosynthesis_Homo sapiens_hsa007901.53337235
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53320113
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53115194
29Carbon metabolism_Homo sapiens_hsa012001.48505794
30Ribosome_Homo sapiens_hsa030101.46472706
31Fatty acid elongation_Homo sapiens_hsa000621.42493304
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39919891
33Adherens junction_Homo sapiens_hsa045201.39875116
34Pyruvate metabolism_Homo sapiens_hsa006201.32337747
35One carbon pool by folate_Homo sapiens_hsa006701.25546238
36TGF-beta signaling pathway_Homo sapiens_hsa043501.23024244
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22902951
38Vitamin B6 metabolism_Homo sapiens_hsa007501.22849297
39Purine metabolism_Homo sapiens_hsa002301.21890322
40Pentose phosphate pathway_Homo sapiens_hsa000301.18895666
41Longevity regulating pathway - mammal_Homo sapiens_hsa042111.13447351
42Bladder cancer_Homo sapiens_hsa052191.13330219
43Basal cell carcinoma_Homo sapiens_hsa052171.10549947
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08493045
45Wnt signaling pathway_Homo sapiens_hsa043101.05568028
46Fatty acid metabolism_Homo sapiens_hsa012121.05543576
47RNA polymerase_Homo sapiens_hsa030201.04456270
48Oocyte meiosis_Homo sapiens_hsa041141.02191445
49Lysine degradation_Homo sapiens_hsa003101.01315759
50Fructose and mannose metabolism_Homo sapiens_hsa000510.94991373
51Shigellosis_Homo sapiens_hsa051310.93733356
52Parkinsons disease_Homo sapiens_hsa050120.93587756
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89435292
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88420111
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85021623
56Huntingtons disease_Homo sapiens_hsa050160.84717195
57RNA degradation_Homo sapiens_hsa030180.83017650
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82420013
59Propanoate metabolism_Homo sapiens_hsa006400.82224411
60Proteasome_Homo sapiens_hsa030500.81055157
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80808610
62Pyrimidine metabolism_Homo sapiens_hsa002400.80347969
63Colorectal cancer_Homo sapiens_hsa052100.80331007
64Basal transcription factors_Homo sapiens_hsa030220.78890662
65MicroRNAs in cancer_Homo sapiens_hsa052060.74321154
66Oxidative phosphorylation_Homo sapiens_hsa001900.73286030
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73033562
68VEGF signaling pathway_Homo sapiens_hsa043700.72681346
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72132392
70Protein export_Homo sapiens_hsa030600.70838839
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68660875
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67479244
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.65997351
74N-Glycan biosynthesis_Homo sapiens_hsa005100.60907504
75Viral carcinogenesis_Homo sapiens_hsa052030.58291424
76Thyroid cancer_Homo sapiens_hsa052160.58163597
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56235112
78Arginine biosynthesis_Homo sapiens_hsa002200.55910112
79Tight junction_Homo sapiens_hsa045300.54216261
80Glutathione metabolism_Homo sapiens_hsa004800.53128115
81Small cell lung cancer_Homo sapiens_hsa052220.52009864
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.51614385
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51354942
84Viral myocarditis_Homo sapiens_hsa054160.50808081
85Galactose metabolism_Homo sapiens_hsa000520.50047455
86Legionellosis_Homo sapiens_hsa051340.49784656
87Acute myeloid leukemia_Homo sapiens_hsa052210.48790241
88Epstein-Barr virus infection_Homo sapiens_hsa051690.47396684
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46288805
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44904089
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44841170
92Herpes simplex infection_Homo sapiens_hsa051680.44607308
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.44263714
94Chronic myeloid leukemia_Homo sapiens_hsa052200.43858188
95AMPK signaling pathway_Homo sapiens_hsa041520.41778705
96Dorso-ventral axis formation_Homo sapiens_hsa043200.37806446
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.37762279
98Choline metabolism in cancer_Homo sapiens_hsa052310.37673515
99Non-homologous end-joining_Homo sapiens_hsa034500.37099058
100Alzheimers disease_Homo sapiens_hsa050100.36716465
101ErbB signaling pathway_Homo sapiens_hsa040120.35052960
102HTLV-I infection_Homo sapiens_hsa051660.34354041
103Insulin signaling pathway_Homo sapiens_hsa049100.33281105
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32876348
105Gap junction_Homo sapiens_hsa045400.30743268
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30555634
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30007403
108Selenocompound metabolism_Homo sapiens_hsa004500.29314434
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28730008
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.27321670
111Fatty acid degradation_Homo sapiens_hsa000710.26988560
112Vitamin digestion and absorption_Homo sapiens_hsa049770.25295785
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24823127
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22900404
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.21817881
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21666706
117Peroxisome_Homo sapiens_hsa041460.21577506
118Pathways in cancer_Homo sapiens_hsa052000.20357623
119Phenylalanine metabolism_Homo sapiens_hsa003600.18852905
120Hepatitis B_Homo sapiens_hsa051610.18186848
121Alcoholism_Homo sapiens_hsa050340.17686473
122Endometrial cancer_Homo sapiens_hsa052130.17248808
123Proteoglycans in cancer_Homo sapiens_hsa052050.16108501
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15857125
125Prostate cancer_Homo sapiens_hsa052150.15402028
126Systemic lupus erythematosus_Homo sapiens_hsa053220.15380698
127Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.14825749
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14804348
129MAPK signaling pathway_Homo sapiens_hsa040100.13950312
130HIF-1 signaling pathway_Homo sapiens_hsa040660.13642311
131Melanoma_Homo sapiens_hsa052180.12368369
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.11873125
133Steroid biosynthesis_Homo sapiens_hsa001000.09659226
134Tyrosine metabolism_Homo sapiens_hsa003500.08647109
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07622392
136Metabolic pathways_Homo sapiens_hsa011000.06309749

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