ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.93177657
2	response to pheromone (GO:0019236)	5.14521429
3	L-fucose catabolic process (GO:0042355)	4.71006665
4	fucose catabolic process (GO:0019317)	4.71006665
5	L-fucose metabolic process (GO:0042354)	4.71006665
6	kynurenine metabolic process (GO:0070189)	4.02220175
7	DNA deamination (GO:0045006)	3.96181287
8	indolalkylamine metabolic process (GO:0006586)	3.88209106
9	tryptophan catabolic process (GO:0006569)	3.85350303
10	indole-containing compound catabolic process (GO:0042436)	3.85350303
11	indolalkylamine catabolic process (GO:0046218)	3.85350303
12	cellular ketone body metabolic process (GO:0046950)	3.81100614
13	negative regulation of telomere maintenance (GO:0032205)	3.64670853
14	detection of light stimulus involved in visual perception (GO:0050908)	3.62640180
15	detection of light stimulus involved in sensory perception (GO:0050962)	3.62640180
16	platelet dense granule organization (GO:0060155)	3.60401281
17	ketone body metabolic process (GO:1902224)	3.56825857
18	respiratory chain complex IV assembly (GO:0008535)	3.45435680
19	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.44153256
20	piRNA metabolic process (GO:0034587)	3.38806143
21	tryptophan metabolic process (GO:0006568)	3.36700918
22	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.33795537
23	regulation of action potential (GO:0098900)	3.31526350
24	water-soluble vitamin biosynthetic process (GO:0042364)	3.20915940
25	retinal cone cell development (GO:0046549)	3.19322541
26	protein complex biogenesis (GO:0070271)	3.19259922
27	protein neddylation (GO:0045116)	3.19075065
28	preassembly of GPI anchor in ER membrane (GO:0016254)	3.14440118
29	glycerophospholipid catabolic process (GO:0046475)	3.13738393
30	cornea development in camera-type eye (GO:0061303)	3.13631544
31	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.11667631
32	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.11667631
33	negative regulation of mast cell activation (GO:0033004)	3.10207631
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.07313547
35	NADH dehydrogenase complex assembly (GO:0010257)	3.07313547
36	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.07313547
37	protein K11-linked deubiquitination (GO:0035871)	3.01314075
38	mitochondrial respiratory chain complex assembly (GO:0033108)	3.01207687
39	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.99898893
40	ATP synthesis coupled proton transport (GO:0015986)	2.99898893
41	indole-containing compound metabolic process (GO:0042430)	2.93917344
42	cytochrome complex assembly (GO:0017004)	2.93316138
43	rRNA catabolic process (GO:0016075)	2.92722948
44	nephron tubule morphogenesis (GO:0072078)	2.91874784
45	nephron epithelium morphogenesis (GO:0072088)	2.91874784
46	protein localization to cilium (GO:0061512)	2.90848765
47	epithelial cilium movement (GO:0003351)	2.84364112
48	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.81768357
49	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.81292571
50	S-adenosylmethionine metabolic process (GO:0046500)	2.79688150
51	sulfation (GO:0051923)	2.79340922
52	nonmotile primary cilium assembly (GO:0035058)	2.78656881
53	gamma-aminobutyric acid transport (GO:0015812)	2.76857277
54	somite development (GO:0061053)	2.75696161
55	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.74401609
56	protein-cofactor linkage (GO:0018065)	2.72968270
57	protein K6-linked ubiquitination (GO:0085020)	2.72353229
58	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.71318926
59	behavioral response to ethanol (GO:0048149)	2.71318029
60	male meiosis I (GO:0007141)	2.68563764
61	reciprocal meiotic recombination (GO:0007131)	2.67850087
62	reciprocal DNA recombination (GO:0035825)	2.67850087
63	auditory receptor cell stereocilium organization (GO:0060088)	2.66816926
64	axoneme assembly (GO:0035082)	2.66687005
65	replication fork processing (GO:0031297)	2.64427017
66	exogenous drug catabolic process (GO:0042738)	2.64395249
67	cilium morphogenesis (GO:0060271)	2.64295375
68	pyrimidine nucleobase catabolic process (GO:0006208)	2.63694895
69	regulation of cilium movement (GO:0003352)	2.62877542
70	mannosylation (GO:0097502)	2.61917875
71	cellular biogenic amine catabolic process (GO:0042402)	2.61233916
72	amine catabolic process (GO:0009310)	2.61233916
73	cAMP catabolic process (GO:0006198)	2.59815000
74	cilium organization (GO:0044782)	2.59163338
75	DNA methylation involved in gamete generation (GO:0043046)	2.58683018
76	protein polyglutamylation (GO:0018095)	2.58635546
77	synapsis (GO:0007129)	2.58271034
78	primary amino compound metabolic process (GO:1901160)	2.57818763
79	kidney morphogenesis (GO:0060993)	2.57713028
80	synaptic transmission, cholinergic (GO:0007271)	2.56293965
81	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.54597033
82	positive regulation of fatty acid transport (GO:2000193)	2.54290252
83	photoreceptor cell development (GO:0042461)	2.53723390
84	polyol catabolic process (GO:0046174)	2.53017591
85	male meiosis (GO:0007140)	2.52727426
86	nucleobase catabolic process (GO:0046113)	2.51178620
87	regulation of hexokinase activity (GO:1903299)	2.50849965
88	regulation of glucokinase activity (GO:0033131)	2.50849965
89	cilium assembly (GO:0042384)	2.49327796
90	neuronal action potential (GO:0019228)	2.48230945
91	renal tubule morphogenesis (GO:0061333)	2.47350600
92	neural tube formation (GO:0001841)	2.46614215
93	positive regulation of prostaglandin secretion (GO:0032308)	2.46412287
94	regulation of telomere maintenance (GO:0032204)	2.45478832
95	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.43277734
96	tRNA processing (GO:0008033)	2.43236891
97	reflex (GO:0060004)	2.42956861
98	recombinational repair (GO:0000725)	2.42925699
99	anterograde synaptic vesicle transport (GO:0048490)	2.42701762
100	peptidyl-histidine modification (GO:0018202)	2.42391559

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.99325477
2	VDR_22108803_ChIP-Seq_LS180_Human	3.35735509
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.95504323
4	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.54293955
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.47166634
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.42365756
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.41358375
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.37332174
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.33184811
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.25357354
11	FUS_26573619_Chip-Seq_HEK293_Human	2.11742697
12	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.08587967
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.06657985
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.06469920
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03832299
16	EWS_26573619_Chip-Seq_HEK293_Human	1.96269598
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.92940569
18	TAF15_26573619_Chip-Seq_HEK293_Human	1.90283075
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89263762
20	P300_19829295_ChIP-Seq_ESCs_Human	1.88959875
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.82413200
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78862092
23	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.74619499
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.72202672
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.69451875
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.68818807
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.67952656
28	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.63883610
29	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.61427620
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57913336
31	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.56066046
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.55204421
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52697158
34	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.45437239
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.45136881
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.45136881
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.43394724
38	STAT3_23295773_ChIP-Seq_U87_Human	1.42904803
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.42363408
40	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.42287261
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41383624
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.41383624
43	REST_21632747_ChIP-Seq_MESCs_Mouse	1.39702371
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.39411955
45	AR_25329375_ChIP-Seq_VCAP_Human	1.39249593
46	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.37981211
47	TCF4_23295773_ChIP-Seq_U87_Human	1.35929895
48	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.35542119
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35182373
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35182373
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.34881049
52	TCF4_22108803_ChIP-Seq_LS180_Human	1.34343919
53	SMAD4_21799915_ChIP-Seq_A2780_Human	1.33547581
54	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33306112
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.32523122
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.31434822
57	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.31323016
58	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.30988090
59	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.28576685
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27946963
61	NCOR_22424771_ChIP-Seq_293T_Human	1.27886491
62	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27348133
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27342458
64	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25654145
65	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.25654145
66	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.25296556
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23170391
68	AR_20517297_ChIP-Seq_VCAP_Human	1.21716534
69	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.21613551
70	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.20421639
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19922394
72	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.19141252
73	HOXB7_26014856_ChIP-Seq_BT474_Human	1.18392864
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17391242
75	VDR_23849224_ChIP-Seq_CD4+_Human	1.17184086
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16431353
77	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.15027966
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.14304367
79	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.14037092
80	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13735522
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13558060
82	AR_21572438_ChIP-Seq_LNCaP_Human	1.12616572
83	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12214384
84	MYC_19829295_ChIP-Seq_ESCs_Human	1.08966248
85	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08157459
86	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.05681801
87	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.05509303
88	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.05238560
89	ELK1_19687146_ChIP-ChIP_HELA_Human	1.04766192
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02995719
91	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02525336
92	TAF2_19829295_ChIP-Seq_ESCs_Human	1.01718847
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01659699
94	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00617304
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00177789
96	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00115048
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99916889
98	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99574340
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98665593
100	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.97712935

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.70180596
2	MP0002102_abnormal_ear_morphology	2.97910972
3	MP0008877_abnormal_DNA_methylation	2.79995374
4	MP0005551_abnormal_eye_electrophysiolog	2.61835803
5	MP0001968_abnormal_touch/_nociception	2.43062361
6	MP0000569_abnormal_digit_pigmentation	2.40852209
7	MP0003136_yellow_coat_color	2.28921111
8	MP0008875_abnormal_xenobiotic_pharmacok	2.24165764
9	MP0000372_irregular_coat_pigmentation	2.21688018
10	MP0009046_muscle_twitch	2.13812292
11	MP0002736_abnormal_nociception_after	2.06173609
12	MP0006292_abnormal_olfactory_placode	2.02320856
13	MP0009745_abnormal_behavioral_response	2.00305076
14	MP0002837_dystrophic_cardiac_calcinosis	1.97951431
15	MP0005646_abnormal_pituitary_gland	1.97578193
16	MP0001986_abnormal_taste_sensitivity	1.95689886
17	MP0003787_abnormal_imprinting	1.95573719
18	MP0006072_abnormal_retinal_apoptosis	1.95382855
19	MP0003646_muscle_fatigue	1.91321537
20	MP0002938_white_spotting	1.91124678
21	MP0004885_abnormal_endolymph	1.88844293
22	MP0002876_abnormal_thyroid_physiology	1.88547135
23	MP0002653_abnormal_ependyma_morphology	1.86510165
24	MP0008872_abnormal_physiological_respon	1.86241991
25	MP0004142_abnormal_muscle_tone	1.82171114
26	MP0005253_abnormal_eye_physiology	1.79695387
27	MP0004043_abnormal_pH_regulation	1.78674686
28	MP0002638_abnormal_pupillary_reflex	1.73609098
29	MP0003283_abnormal_digestive_organ	1.72783552
30	MP0002272_abnormal_nervous_system	1.71541351
31	MP0003011_delayed_dark_adaptation	1.65903533
32	MP0001501_abnormal_sleep_pattern	1.60879314
33	MP0002163_abnormal_gland_morphology	1.56179925
34	MP0005075_abnormal_melanosome_morpholog	1.54130544
35	MP0005645_abnormal_hypothalamus_physiol	1.53619649
36	MP0000631_abnormal_neuroendocrine_gland	1.50031786
37	MP0003880_abnormal_central_pattern	1.48342128
38	MP0002064_seizures	1.47589801
39	MP0001984_abnormal_olfaction	1.44836106
40	MP0001486_abnormal_startle_reflex	1.38854698
41	MP0005379_endocrine/exocrine_gland_phen	1.36490105
42	MP0004147_increased_porphyrin_level	1.36487853
43	MP0002572_abnormal_emotion/affect_behav	1.36418305
44	MP0004133_heterotaxia	1.35423667
45	MP0010386_abnormal_urinary_bladder	1.32718380
46	MP0001485_abnormal_pinna_reflex	1.32675554
47	MP0000427_abnormal_hair_cycle	1.31941797
48	MP0002277_abnormal_respiratory_mucosa	1.31771744
49	MP0005084_abnormal_gallbladder_morpholo	1.26854271
50	MP0005174_abnormal_tail_pigmentation	1.25567713
51	MP0006276_abnormal_autonomic_nervous	1.23548590
52	MP0001529_abnormal_vocalization	1.23292167
53	MP0005389_reproductive_system_phenotype	1.19957605
54	MP0002557_abnormal_social/conspecific_i	1.17732911
55	MP0001970_abnormal_pain_threshold	1.13715112
56	MP0002735_abnormal_chemical_nociception	1.12451622
57	MP0004742_abnormal_vestibular_system	1.12396563
58	MP0005386_behavior/neurological_phenoty	1.10473637
59	MP0004924_abnormal_behavior	1.10473637
60	MP0001919_abnormal_reproductive_system	1.08914669
61	MP0002733_abnormal_thermal_nociception	1.08208680
62	MP0005167_abnormal_blood-brain_barrier	1.08103170
63	MP0005195_abnormal_posterior_eye	1.04192435
64	MP0000383_abnormal_hair_follicle	1.04110946
65	MP0002160_abnormal_reproductive_system	1.03961587
66	MP0002067_abnormal_sensory_capabilities	1.01334915
67	MP0003878_abnormal_ear_physiology	1.00877798
68	MP0005377_hearing/vestibular/ear_phenot	1.00877798
69	MP0004145_abnormal_muscle_electrophysio	1.00570376
70	MP0002063_abnormal_learning/memory/cond	0.99539352
71	MP0003635_abnormal_synaptic_transmissio	0.99405854
72	MP0003137_abnormal_impulse_conducting	0.97141552
73	MP0002234_abnormal_pharynx_morphology	0.95136304
74	MP0002928_abnormal_bile_duct	0.94837875
75	MP0005332_abnormal_amino_acid	0.94709729
76	MP0004215_abnormal_myocardial_fiber	0.91125577
77	MP0002095_abnormal_skin_pigmentation	0.90842573
78	MP0001502_abnormal_circadian_rhythm	0.90805052
79	MP0005410_abnormal_fertilization	0.89840480
80	MP0002229_neurodegeneration	0.89310864
81	MP0002909_abnormal_adrenal_gland	0.88962144
82	MP0002752_abnormal_somatic_nervous	0.88168405
83	MP0001324_abnormal_eye_pigmentation	0.87031966
84	MP0001293_anophthalmia	0.86858253
85	MP0003718_maternal_effect	0.85357606
86	MP0008058_abnormal_DNA_repair	0.84696874
87	MP0000026_abnormal_inner_ear	0.83676931
88	MP0002693_abnormal_pancreas_physiology	0.83608188
89	MP0001905_abnormal_dopamine_level	0.81903895
90	MP0000647_abnormal_sebaceous_gland	0.79558774
91	MP0003698_abnormal_male_reproductive	0.79446515
92	MP0005423_abnormal_somatic_nervous	0.79319030
93	MP0002751_abnormal_autonomic_nervous	0.78902545
94	MP0005365_abnormal_bile_salt	0.77818526
95	MP0002734_abnormal_mechanical_nocicepti	0.77215463
96	MP0005391_vision/eye_phenotype	0.75572113
97	MP0003119_abnormal_digestive_system	0.75188561
98	MP0002210_abnormal_sex_determination	0.75141805
99	MP0000230_abnormal_systemic_arterial	0.74721747
100	MP0001963_abnormal_hearing_physiology	0.73934307

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	4.34014235
2	Molar tooth sign on MRI (HP:0002419)	4.34014235
3	Congenital stationary night blindness (HP:0007642)	4.20914591
4	Pancreatic cysts (HP:0001737)	4.12101577
5	Pancreatic fibrosis (HP:0100732)	3.88635841
6	True hermaphroditism (HP:0010459)	3.72901599
7	Nephronophthisis (HP:0000090)	3.54692000
8	Type II lissencephaly (HP:0007260)	3.36842760
9	Abnormal rod and cone electroretinograms (HP:0008323)	3.11640922
10	Attenuation of retinal blood vessels (HP:0007843)	3.07165032
11	Abnormality of the renal cortex (HP:0011035)	3.02428922
12	Abnormality of the renal medulla (HP:0100957)	2.98930640
13	Hyperventilation (HP:0002883)	2.90795195
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.89452046
15	Decreased central vision (HP:0007663)	2.86691784
16	Medial flaring of the eyebrow (HP:0010747)	2.86022598
17	Abolished electroretinogram (ERG) (HP:0000550)	2.83180071
18	Pendular nystagmus (HP:0012043)	2.67805557
19	Tubular atrophy (HP:0000092)	2.65773691
20	Chronic hepatic failure (HP:0100626)	2.62268556
21	Large for gestational age (HP:0001520)	2.54157795
22	Abnormality of the pons (HP:0007361)	2.51731191
23	Cystic liver disease (HP:0006706)	2.50648039
24	Abnormal drinking behavior (HP:0030082)	2.47816812
25	Polydipsia (HP:0001959)	2.47816812
26	Increased corneal curvature (HP:0100692)	2.46980117
27	Keratoconus (HP:0000563)	2.46980117
28	Hypoplasia of the pons (HP:0012110)	2.44414274
29	Lissencephaly (HP:0001339)	2.42650406
30	Mitochondrial inheritance (HP:0001427)	2.42556182
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.40422065
32	Absent/shortened dynein arms (HP:0200106)	2.39911529
33	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.39911529
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.38744519
35	Abnormality of alanine metabolism (HP:0010916)	2.38744519
36	Hyperalaninemia (HP:0003348)	2.38744519
37	Abnormal biliary tract physiology (HP:0012439)	2.37672258
38	Bile duct proliferation (HP:0001408)	2.37672258
39	Sclerocornea (HP:0000647)	2.35929324
40	Renal cortical cysts (HP:0000803)	2.34534065
41	Inability to walk (HP:0002540)	2.32385885
42	Hypoplasia of the fovea (HP:0007750)	2.29172392
43	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.29172392
44	Increased CSF lactate (HP:0002490)	2.28358695
45	Gait imbalance (HP:0002141)	2.28225348
46	Acute necrotizing encephalopathy (HP:0006965)	2.28057413
47	Congenital primary aphakia (HP:0007707)	2.22102069
48	Retinal dysplasia (HP:0007973)	2.21249280
49	Concave nail (HP:0001598)	2.19793119
50	Cerebellar dysplasia (HP:0007033)	2.19313510
51	Congenital, generalized hypertrichosis (HP:0004540)	2.18714843
52	Hepatic necrosis (HP:0002605)	2.16365090
53	Hepatocellular necrosis (HP:0001404)	2.15244970
54	Anencephaly (HP:0002323)	2.12282880
55	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.11744327
56	Acute encephalopathy (HP:0006846)	2.09931340
57	Pachygyria (HP:0001302)	2.05340860
58	Hypothermia (HP:0002045)	2.03117836
59	Progressive macrocephaly (HP:0004481)	2.02441200
60	Decreased circulating renin level (HP:0003351)	2.02290379
61	Polyuria (HP:0000103)	2.01245097
62	Furrowed tongue (HP:0000221)	1.99038646
63	Abnormality of macular pigmentation (HP:0008002)	1.98927902
64	Nephrogenic diabetes insipidus (HP:0009806)	1.98222678
65	Abnormality of the labia minora (HP:0012880)	1.97728044
66	Abnormal mitochondria in muscle tissue (HP:0008316)	1.97708240
67	Hemiparesis (HP:0001269)	1.96850791
68	Stomatitis (HP:0010280)	1.96278752
69	Tachypnea (HP:0002789)	1.95440390
70	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.94808255
71	Disproportionate short-trunk short stature (HP:0003521)	1.94749750
72	Optic disc pallor (HP:0000543)	1.94133046
73	Constricted visual fields (HP:0001133)	1.93063169
74	Abnormality of the fovea (HP:0000493)	1.92478717
75	Genital tract atresia (HP:0001827)	1.90776887
76	Congenital hepatic fibrosis (HP:0002612)	1.90736328
77	Male pseudohermaphroditism (HP:0000037)	1.89406312
78	Severe muscular hypotonia (HP:0006829)	1.87986736
79	Patellar aplasia (HP:0006443)	1.87145423
80	Lipid accumulation in hepatocytes (HP:0006561)	1.86806933
81	Hypomagnesemia (HP:0002917)	1.85684969
82	Abnormal respiratory epithelium morphology (HP:0012253)	1.85682130
83	Abnormal respiratory motile cilium morphology (HP:0005938)	1.85682130
84	Postaxial foot polydactyly (HP:0001830)	1.84233871
85	3-Methylglutaconic aciduria (HP:0003535)	1.84229411
86	Bony spicule pigmentary retinopathy (HP:0007737)	1.83258731
87	Methylmalonic acidemia (HP:0002912)	1.83100507
88	Gaze-evoked nystagmus (HP:0000640)	1.81516670
89	Progressive inability to walk (HP:0002505)	1.80837278
90	Aplasia/Hypoplasia of the patella (HP:0006498)	1.80063984
91	Vaginal atresia (HP:0000148)	1.78541081
92	Methylmalonic aciduria (HP:0012120)	1.75714166
93	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.74033828
94	Broad-based gait (HP:0002136)	1.73499230
95	Oligodactyly (hands) (HP:0001180)	1.72025854
96	Increased hepatocellular lipid droplets (HP:0006565)	1.71808018
97	Aplasia/hypoplasia of the uterus (HP:0008684)	1.71634309
98	Optic nerve hypoplasia (HP:0000609)	1.71097237
99	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.71044675
100	Congenital sensorineural hearing impairment (HP:0008527)	1.70755456

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.77272077
2	ADRBK2	3.52810417
3	GRK1	2.92023850
4	WNK3	2.76735447
5	TLK1	2.64935655
6	NUAK1	2.59330499
7	ZAK	2.59195969
8	WNK4	2.57933143
9	DAPK2	2.39761842
10	MAP4K2	2.38563212
11	PINK1	2.25315358
12	BMPR1B	2.21012980
13	INSRR	2.13523390
14	TAOK3	1.89987786
15	MAPK13	1.79435819
16	STK38L	1.76557797
17	ACVR1B	1.69795077
18	MAP3K4	1.67900484
19	STK39	1.65048126
20	OXSR1	1.56668257
21	CASK	1.48460282
22	TXK	1.29930968
23	MAP2K6	1.25857225
24	FGFR2	1.23740496
25	MAP2K7	1.19660744
26	VRK2	1.14171258
27	ADRBK1	1.14135878
28	VRK1	1.13667411
29	MARK1	1.09458658
30	PIK3CA	1.09226553
31	PAK3	1.05038785
32	EPHA4	1.04714222
33	NME1	1.02472983
34	PHKG2	1.01405791
35	PHKG1	1.01405791
36	DYRK2	1.00692593
37	PRKCG	1.00183792
38	NTRK3	0.98684850
39	PRKCE	0.98387472
40	MST4	0.96584700
41	PNCK	0.92844258
42	CSNK1G2	0.92495284
43	TIE1	0.89895786
44	MUSK	0.82467757
45	IKBKB	0.81844219
46	TSSK6	0.81641198
47	MKNK2	0.81416495
48	TRIM28	0.80798555
49	CAMKK2	0.79822850
50	CSNK1G1	0.79795733
51	TNIK	0.78784990
52	NTRK2	0.77050382
53	TRPM7	0.76603222
54	MAPKAPK3	0.76446515
55	CSNK1G3	0.72776571
56	PTK2B	0.72733587
57	PRKCQ	0.71020194
58	WEE1	0.68375434
59	BRSK2	0.68252314
60	PLK2	0.67951247
61	PLK3	0.65500766
62	BCKDK	0.64608560
63	IRAK1	0.64204671
64	CAMK2A	0.64101796
65	ERBB3	0.63893484
66	TEC	0.58632380
67	CSNK1A1L	0.57389100
68	ITK	0.54472849
69	MAPK15	0.53372792
70	TGFBR1	0.53174980
71	STK11	0.52856645
72	PRKACA	0.51109567
73	RPS6KA5	0.49195401
74	PKN1	0.48989595
75	MAPKAPK5	0.48215209
76	PLK1	0.47787498
77	PLK4	0.46751078
78	GRK7	0.45607014
79	ATR	0.42319546
80	TNK2	0.42317957
81	PRKCZ	0.41827580
82	CSNK1A1	0.41692573
83	LIMK1	0.41688572
84	STK3	0.41544449
85	ERBB2	0.40889219
86	PRKCA	0.40573561
87	PRKCI	0.40374981
88	EIF2AK3	0.40040026
89	CAMK1	0.39681156
90	KIT	0.39465052
91	MAP2K4	0.39231006
92	CSNK1D	0.38742821
93	BCR	0.37817779
94	CAMK2D	0.37245394
95	SIK2	0.36594695
96	PIK3CG	0.35716725
97	STK16	0.35348011
98	PRKG1	0.34515138
99	OBSCN	0.34186389
100	TAF1	0.33587480

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.87716496
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.68023282
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.66308369
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.59625411
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.54700989
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.41690039
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.32212689
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.28938060
9	Protein export_Homo sapiens_hsa03060	2.24263461
10	Nicotine addiction_Homo sapiens_hsa05033	2.24142041
11	Butanoate metabolism_Homo sapiens_hsa00650	2.23315820
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.19521731
13	Selenocompound metabolism_Homo sapiens_hsa00450	2.02995769
14	Ether lipid metabolism_Homo sapiens_hsa00565	2.02806669
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.02016400
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.98358237
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.94801096
18	Caffeine metabolism_Homo sapiens_hsa00232	1.89310043
19	Parkinsons disease_Homo sapiens_hsa05012	1.87421476
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.85238045
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.76920809
22	One carbon pool by folate_Homo sapiens_hsa00670	1.63241155
23	Homologous recombination_Homo sapiens_hsa03440	1.60302912
24	RNA polymerase_Homo sapiens_hsa03020	1.58218096
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.41054364
26	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.38958545
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.33200146
28	Huntingtons disease_Homo sapiens_hsa05016	1.32737610
29	Basal transcription factors_Homo sapiens_hsa03022	1.30101266
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.29443052
31	Alzheimers disease_Homo sapiens_hsa05010	1.23443680
32	Morphine addiction_Homo sapiens_hsa05032	1.23159561
33	Olfactory transduction_Homo sapiens_hsa04740	1.22944864
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.22175104
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.14551710
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.13846028
37	Proteasome_Homo sapiens_hsa03050	1.13121760
38	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.12945972
39	ABC transporters_Homo sapiens_hsa02010	1.12611103
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.12560971
41	Peroxisome_Homo sapiens_hsa04146	1.10575888
42	Regulation of autophagy_Homo sapiens_hsa04140	1.04307170
43	RNA degradation_Homo sapiens_hsa03018	1.03172967
44	Taste transduction_Homo sapiens_hsa04742	1.01381259
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.98684845
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.98343979
47	Propanoate metabolism_Homo sapiens_hsa00640	0.95953033
48	GABAergic synapse_Homo sapiens_hsa04727	0.95284212
49	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.95222084
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.90907566
51	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.88391517
52	Sulfur relay system_Homo sapiens_hsa04122	0.85511506
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.84766640
54	Insulin secretion_Homo sapiens_hsa04911	0.83131428
55	Retinol metabolism_Homo sapiens_hsa00830	0.83048327
56	Type I diabetes mellitus_Homo sapiens_hsa04940	0.81182636
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.81063982
58	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.80889525
59	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.80339817
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.79988265
61	Asthma_Homo sapiens_hsa05310	0.77951852
62	Sulfur metabolism_Homo sapiens_hsa00920	0.77651535
63	Circadian entrainment_Homo sapiens_hsa04713	0.77437799
64	Serotonergic synapse_Homo sapiens_hsa04726	0.76700362
65	Primary immunodeficiency_Homo sapiens_hsa05340	0.74599657
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73527174
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.70968867
68	Histidine metabolism_Homo sapiens_hsa00340	0.70265993
69	Mineral absorption_Homo sapiens_hsa04978	0.70116835
70	Glutamatergic synapse_Homo sapiens_hsa04724	0.69976618
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.67130719
72	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66865800
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63938921
74	Metabolic pathways_Homo sapiens_hsa01100	0.63710266
75	Purine metabolism_Homo sapiens_hsa00230	0.63620712
76	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.63527996
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.59032806
78	Graft-versus-host disease_Homo sapiens_hsa05332	0.56968483
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.55173100
80	Folate biosynthesis_Homo sapiens_hsa00790	0.55143439
81	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.49259831
82	Calcium signaling pathway_Homo sapiens_hsa04020	0.47861158
83	Circadian rhythm_Homo sapiens_hsa04710	0.46826631
84	Salivary secretion_Homo sapiens_hsa04970	0.46051106
85	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.45965553
86	Ribosome_Homo sapiens_hsa03010	0.43290966
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42385933
88	Fatty acid degradation_Homo sapiens_hsa00071	0.42351459
89	Allograft rejection_Homo sapiens_hsa05330	0.40426006
90	Steroid biosynthesis_Homo sapiens_hsa00100	0.39624263
91	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.39298812
92	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.38655172
93	Dopaminergic synapse_Homo sapiens_hsa04728	0.36688948
94	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35429193
95	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.34878880
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33439073
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.31595469
98	Rheumatoid arthritis_Homo sapiens_hsa05323	0.30141600
99	Pyrimidine metabolism_Homo sapiens_hsa00240	0.30018836
100	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.29854826

UNGP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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