UNGP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleoside diphosphate catabolic process (GO:0009134)5.23420601
2estrogen biosynthetic process (GO:0006703)5.12079441
3CDP-diacylglycerol biosynthetic process (GO:0016024)4.78264940
4negative regulation of execution phase of apoptosis (GO:1900118)4.76385156
5water-soluble vitamin biosynthetic process (GO:0042364)4.67767332
6positive regulation of glycoprotein biosynthetic process (GO:0010560)4.62697464
7attachment of spindle microtubules to kinetochore (GO:0008608)4.49807392
8replication fork processing (GO:0031297)4.34787949
9protein neddylation (GO:0045116)4.31834264
10negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.28357375
11astrocyte development (GO:0014002)4.18079711
12cardiolipin metabolic process (GO:0032048)4.12272570
13estrogen metabolic process (GO:0008210)3.99359792
14positive regulation of cell cycle G1/S phase transition (GO:1902808)3.95311718
15CDP-diacylglycerol metabolic process (GO:0046341)3.95158655
16purine deoxyribonucleotide catabolic process (GO:0009155)3.94717699
17adaptation of signaling pathway (GO:0023058)3.86103736
18potassium ion export (GO:0071435)3.84862800
19DNA double-strand break processing (GO:0000729)3.82776514
20positive regulation of glycoprotein metabolic process (GO:1903020)3.76621656
21cornea development in camera-type eye (GO:0061303)3.72183653
22regulation of protein glycosylation (GO:0060049)3.70082671
23deoxyribonucleotide catabolic process (GO:0009264)3.66116509
24regulation of acyl-CoA biosynthetic process (GO:0050812)3.64409314
25dopamine transport (GO:0015872)3.61832084
26aspartate family amino acid catabolic process (GO:0009068)3.49086820
27behavioral response to cocaine (GO:0048148)3.41785775
28positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)3.41122464
29regulation of neurotransmitter uptake (GO:0051580)3.40481890
30maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.40060867
31regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.39636335
32regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.39636335
33regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.36900473
34regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)3.36283134
35organelle membrane fusion (GO:0090174)3.36123885
36viral mRNA export from host cell nucleus (GO:0046784)3.31449827
37deoxyribose phosphate catabolic process (GO:0046386)3.29684735
38positive regulation of histone H3-K4 methylation (GO:0051571)3.25869927
39nodal signaling pathway (GO:0038092)3.21173127
40deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.18250413
41regulation of dopamine metabolic process (GO:0042053)3.16085077
42regulation of catecholamine metabolic process (GO:0042069)3.16085077
43regulation of cofactor metabolic process (GO:0051193)3.13924282
44regulation of coenzyme metabolic process (GO:0051196)3.13924282
45cholesterol biosynthetic process (GO:0006695)3.13812884
46adult feeding behavior (GO:0008343)3.13369569
47serotonin metabolic process (GO:0042428)3.10893967
48negative regulation of DNA recombination (GO:0045910)3.08315965
49sterol biosynthetic process (GO:0016126)3.05926063
50positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.04475178
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.01380337
52DNA deamination (GO:0045006)3.01126964
53kinetochore organization (GO:0051383)2.98112150
54behavioral response to nicotine (GO:0035095)2.96330030
55protein K6-linked ubiquitination (GO:0085020)2.95940472
56hepatocyte differentiation (GO:0070365)2.95313179
57deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.95122487
58positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.91536341
59kinetochore assembly (GO:0051382)2.90718297
60L-alpha-amino acid transmembrane transport (GO:1902475)2.90157205
61serotonin receptor signaling pathway (GO:0007210)2.87596361
62negative regulation of thymocyte apoptotic process (GO:0070244)2.86775032
63chaperone-mediated protein transport (GO:0072321)2.85507190
64arginine catabolic process (GO:0006527)2.85263486
65positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.84144445
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81202652
67single strand break repair (GO:0000012)2.80891993
68phosphatidylcholine biosynthetic process (GO:0006656)2.80668566
69regulation of glycoprotein biosynthetic process (GO:0010559)2.79477333
70histone-serine phosphorylation (GO:0035404)2.77641157
71transcription from mitochondrial promoter (GO:0006390)2.76002540
72mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.75491835
73long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.74631809
74tricarboxylic acid cycle (GO:0006099)2.71829459
75protein-cofactor linkage (GO:0018065)2.71299744
76CENP-A containing nucleosome assembly (GO:0034080)2.66970445
77negative regulation of activin receptor signaling pathway (GO:0032926)2.66942894
78histone exchange (GO:0043486)2.66335546
79pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.65632655
80toxin metabolic process (GO:0009404)2.65281738
81deoxyribonucleotide metabolic process (GO:0009262)2.65235668
82primary amino compound metabolic process (GO:1901160)2.65209038
83preassembly of GPI anchor in ER membrane (GO:0016254)2.63957227
84regulation of collateral sprouting (GO:0048670)2.63122641
85recombinational repair (GO:0000725)2.62527402
86adenosine metabolic process (GO:0046085)2.62383304
87fatty-acyl-CoA biosynthetic process (GO:0046949)2.59369751
88chromatin remodeling at centromere (GO:0031055)2.59181342
89spermatid nucleus differentiation (GO:0007289)2.58132514
90somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.56585256
91isotype switching (GO:0045190)2.56585256
92somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.56585256
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.55848454
94tachykinin receptor signaling pathway (GO:0007217)2.54837730
95platelet dense granule organization (GO:0060155)2.54509397
96seminiferous tubule development (GO:0072520)2.53090954
97purine deoxyribonucleotide metabolic process (GO:0009151)2.52662133
98negative regulation of DNA-dependent DNA replication (GO:2000104)2.52436574
99synaptic transmission, dopaminergic (GO:0001963)2.51539157
100high-density lipoprotein particle remodeling (GO:0034375)2.51369288

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.08450172
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.03531186
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.46304669
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.40696483
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.13125150
6FUS_26573619_Chip-Seq_HEK293_Human2.78224264
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71048710
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.67667389
9GATA1_22025678_ChIP-Seq_K562_Human2.62728476
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.53844119
11ZNF274_21170338_ChIP-Seq_K562_Hela2.47498029
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46867794
13HTT_18923047_ChIP-ChIP_STHdh_Human2.37498839
14EWS_26573619_Chip-Seq_HEK293_Human2.28865621
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.22145510
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19592566
17ELK1_19687146_ChIP-ChIP_HELA_Human2.17929495
18IRF1_19129219_ChIP-ChIP_H3396_Human2.15776781
19GBX2_23144817_ChIP-Seq_PC3_Human2.13037962
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06327909
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04129679
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95085859
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91029981
24IGF1R_20145208_ChIP-Seq_DFB_Human1.90420809
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.88369905
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81539332
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.80491962
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75848570
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75694966
30MYC_18940864_ChIP-ChIP_HL60_Human1.71860206
31BCAT_22108803_ChIP-Seq_LS180_Human1.69332202
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62382108
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59203347
34P300_19829295_ChIP-Seq_ESCs_Human1.58513407
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.58292071
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.57938118
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54777252
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53959309
39VDR_23849224_ChIP-Seq_CD4+_Human1.52972229
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.50986717
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50773937
42ER_23166858_ChIP-Seq_MCF-7_Human1.50020796
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49534532
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44303262
45SMAD4_21799915_ChIP-Seq_A2780_Human1.39676562
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38765588
47VDR_22108803_ChIP-Seq_LS180_Human1.38466163
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.37301826
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33520220
50CRX_20693478_ChIP-Seq_RETINA_Mouse1.32209426
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30035682
52RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25029714
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24627559
54NANOG_16153702_ChIP-ChIP_HESCs_Human1.22271582
55TCF4_22108803_ChIP-Seq_LS180_Human1.20562612
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20491809
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.20005632
58SMAD4_21741376_ChIP-Seq_EPCs_Human1.18969689
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.15914588
60OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14897349
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12701487
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12313849
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09407071
64AR_20517297_ChIP-Seq_VCAP_Human1.09284293
65P53_22387025_ChIP-Seq_ESCs_Mouse1.09129631
66EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08995375
67SOX2_18555785_Chip-Seq_ESCs_Mouse1.08839856
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08003304
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07960749
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.07959175
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.07599751
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07423781
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06816824
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05138248
75SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03582386
76TAF15_26573619_Chip-Seq_HEK293_Human1.01455139
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01051871
78TAL1_26923725_Chip-Seq_HPCs_Mouse0.98070718
79SOX2_19829295_ChIP-Seq_ESCs_Human0.97483087
80NANOG_19829295_ChIP-Seq_ESCs_Human0.97483087
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96795141
82RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96683526
83SMAD3_21741376_ChIP-Seq_EPCs_Human0.96492365
84CBP_20019798_ChIP-Seq_JUKART_Human0.96403791
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96403791
86FOXP3_21729870_ChIP-Seq_TREG_Human0.96128455
87FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95614833
88ETS1_20019798_ChIP-Seq_JURKAT_Human0.95389714
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94316623
90TCF4_23295773_ChIP-Seq_U87_Human0.94255810
91EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94234805
92CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94163405
93SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94134694
94FOXM1_23109430_ChIP-Seq_U2OS_Human0.93571880
95STAT3_23295773_ChIP-Seq_U87_Human0.93369882
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93071612
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91669603
98P300_18555785_Chip-Seq_ESCs_Mouse0.91595017
99PU1_27457419_Chip-Seq_LIVER_Mouse0.89970968
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89684067

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland4.48070382
2MP0002837_dystrophic_cardiac_calcinosis3.31714142
3MP0008995_early_reproductive_senescence3.17972388
4MP0009697_abnormal_copulation3.05014403
5MP0006292_abnormal_olfactory_placode2.85754433
6MP0006072_abnormal_retinal_apoptosis2.79560390
7MP0005367_renal/urinary_system_phenotyp2.79076485
8MP0000516_abnormal_urinary_system2.79076485
9MP0005248_abnormal_Harderian_gland2.72371341
10MP0009780_abnormal_chondrocyte_physiolo2.63046261
11MP0005084_abnormal_gallbladder_morpholo2.57948221
12MP0003195_calcinosis2.50430306
13MP0008877_abnormal_DNA_methylation2.40477187
14MP0001346_abnormal_lacrimal_gland2.25672827
15MP0003786_premature_aging2.10034792
16MP0000372_irregular_coat_pigmentation2.04868541
17MP0003890_abnormal_embryonic-extraembry2.03054674
18MP0003011_delayed_dark_adaptation2.02063587
19MP0005645_abnormal_hypothalamus_physiol1.99434934
20MP0005365_abnormal_bile_salt1.98369284
21MP0003718_maternal_effect1.90378357
22MP0010329_abnormal_lipoprotein_level1.84174665
23MP0005551_abnormal_eye_electrophysiolog1.82750626
24MP0003122_maternal_imprinting1.76201438
25MP0003806_abnormal_nucleotide_metabolis1.76054685
26MP0002163_abnormal_gland_morphology1.75953497
27MP0000566_synostosis1.75904630
28MP0000579_abnormal_nail_morphology1.74702974
29MP0005253_abnormal_eye_physiology1.74603470
30MP0005464_abnormal_platelet_physiology1.72884167
31MP0008789_abnormal_olfactory_epithelium1.70889600
32MP0008058_abnormal_DNA_repair1.69121131
33MP0005332_abnormal_amino_acid1.68332888
34MP0008004_abnormal_stomach_pH1.67973031
35MP0000613_abnormal_salivary_gland1.66182229
36MP0008872_abnormal_physiological_respon1.53034908
37MP0003943_abnormal_hepatobiliary_system1.46312496
38MP0005379_endocrine/exocrine_gland_phen1.46290452
39MP0001919_abnormal_reproductive_system1.43826811
40MP0000631_abnormal_neuroendocrine_gland1.40509104
41MP0002102_abnormal_ear_morphology1.39322943
42MP0005394_taste/olfaction_phenotype1.35827861
43MP0005499_abnormal_olfactory_system1.35827861
44MP0002653_abnormal_ependyma_morphology1.32127995
45MP0010030_abnormal_orbit_morphology1.28441296
46MP0005389_reproductive_system_phenotype1.16303221
47MP0006276_abnormal_autonomic_nervous1.14556103
48MP0003656_abnormal_erythrocyte_physiolo1.13340058
49MP0002938_white_spotting1.12766808
50MP0006036_abnormal_mitochondrial_physio1.12101519
51MP0000013_abnormal_adipose_tissue1.12074498
52MP0001661_extended_life_span1.11986289
53MP0004133_heterotaxia1.11956059
54MP0004019_abnormal_vitamin_homeostasis1.11777066
55MP0005535_abnormal_body_temperature1.09428863
56MP0000383_abnormal_hair_follicle1.07212810
57MP0003693_abnormal_embryo_hatching1.06665069
58MP0004134_abnormal_chest_morphology1.05798032
59MP0008007_abnormal_cellular_replicative1.05757693
60MP0000647_abnormal_sebaceous_gland1.04795319
61MP0002090_abnormal_vision1.02034775
62MP0001664_abnormal_digestion0.98395172
63MP0005636_abnormal_mineral_homeostasis0.97326433
64MP0001324_abnormal_eye_pigmentation0.96928798
65MP0005647_abnormal_sex_gland0.96442653
66MP0001529_abnormal_vocalization0.95855905
67MP0003698_abnormal_male_reproductive0.92696746
68MP0002736_abnormal_nociception_after0.91045867
69MP0000653_abnormal_sex_gland0.90474782
70MP0001929_abnormal_gametogenesis0.85692559
71MP0010094_abnormal_chromosome_stability0.84566270
72MP0001666_abnormal_nutrient_absorption0.83916469
73MP0002210_abnormal_sex_determination0.82663824
74MP0000230_abnormal_systemic_arterial0.80092831
75MP0001145_abnormal_male_reproductive0.79982436
76MP0010678_abnormal_skin_adnexa0.79022767
77MP0004957_abnormal_blastocyst_morpholog0.77354364
78MP0001756_abnormal_urination0.75919720
79MP0004883_abnormal_blood_vessel0.75879063
80MP0005410_abnormal_fertilization0.75498988
81MP0004130_abnormal_muscle_cell0.75111264
82MP0001270_distended_abdomen0.74621996
83MP0002233_abnormal_nose_morphology0.74285626
84MP0005391_vision/eye_phenotype0.70919160
85MP0002069_abnormal_eating/drinking_beha0.69574781
86MP0004272_abnormal_basement_membrane0.69543240
87MP0005195_abnormal_posterior_eye0.68853449
88MP0002693_abnormal_pancreas_physiology0.68670443
89MP0002638_abnormal_pupillary_reflex0.68666506
90MP0001984_abnormal_olfaction0.66828416
91MP0003111_abnormal_nucleus_morphology0.66773363
92MP0005670_abnormal_white_adipose0.66466693
93MP0005395_other_phenotype0.65733619
94MP0001119_abnormal_female_reproductive0.63827075
95MP0002132_abnormal_respiratory_system0.62085841
96MP0003119_abnormal_digestive_system0.61824035
97MP0001727_abnormal_embryo_implantation0.60039389
98MP0000358_abnormal_cell_content/0.59307155
99MP0001968_abnormal_touch/_nociception0.59221918
100MP0003953_abnormal_hormone_level0.58280545

Predicted human phenotypes

RankGene SetZ-score
1Intestinal atresia (HP:0011100)6.42027173
2Stomach cancer (HP:0012126)4.69498868
3Abnormality of the labia minora (HP:0012880)4.17178866
4Spontaneous abortion (HP:0005268)3.66357759
5Abnormality of the proximal phalanges of the hand (HP:0009834)3.61231981
6Gastrointestinal atresia (HP:0002589)3.52912805
7Acute encephalopathy (HP:0006846)3.44665328
8Hypothermia (HP:0002045)3.27905058
9Acute necrotizing encephalopathy (HP:0006965)3.20362814
10Progressive macrocephaly (HP:0004481)3.12692378
11Gonadotropin excess (HP:0000837)2.91979934
12Anteriorly placed anus (HP:0001545)2.74543018
13Pancreatic fibrosis (HP:0100732)2.74499528
14Abnormal mitochondria in muscle tissue (HP:0008316)2.73738083
15Abnormality of the phalanges of the 2nd finger (HP:0009541)2.68421078
16Abnormality of chromosome stability (HP:0003220)2.66760537
17Generalized aminoaciduria (HP:0002909)2.65548457
18Mitochondrial inheritance (HP:0001427)2.64333223
19Pancreatic cysts (HP:0001737)2.60687944
20Nausea (HP:0002018)2.55128348
21Aplasia involving bones of the upper limbs (HP:0009823)2.52773592
22Aplasia of the phalanges of the hand (HP:0009802)2.52773592
23Aplasia involving bones of the extremities (HP:0009825)2.52773592
24Prostate neoplasm (HP:0100787)2.52055427
25Abnormality of the middle phalanges of the toes (HP:0010183)2.48091283
26Hyperglycemia (HP:0003074)2.40861251
27Adactyly (HP:0009776)2.37547607
28Irregular vertebral endplates (HP:0003301)2.35600283
29Abdominal situs inversus (HP:0003363)2.35549040
30Abnormality of abdominal situs (HP:0011620)2.35549040
31Abnormality of the duodenum (HP:0002246)2.34497777
32Abnormality of midbrain morphology (HP:0002418)2.32827730
33Molar tooth sign on MRI (HP:0002419)2.32827730
34Supernumerary spleens (HP:0009799)2.32171383
35True hermaphroditism (HP:0010459)2.30723379
36Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.30290927
37Short 1st metacarpal (HP:0010034)2.30290927
38Proximal tubulopathy (HP:0000114)2.18889570
39Increased hepatocellular lipid droplets (HP:0006565)2.16492847
40Nephronophthisis (HP:0000090)2.15978590
41Cortical dysplasia (HP:0002539)2.15825552
42Renal Fanconi syndrome (HP:0001994)2.15308520
43Adrenal hypoplasia (HP:0000835)2.14191312
44Delayed puberty (HP:0000823)2.12970215
45Chronic otitis media (HP:0000389)2.12843439
46Abnormal biliary tract morphology (HP:0012440)2.10914923
47Colon cancer (HP:0003003)2.07515674
48Increased CSF lactate (HP:0002490)2.04767834
49Methylmalonic acidemia (HP:0002912)2.03336595
50Growth hormone deficiency (HP:0000824)2.02480079
51Poor head control (HP:0002421)2.01832794
52Abnormality of the prostate (HP:0008775)2.01192374
53Thyroiditis (HP:0100646)2.00919762
54Abnormality of the 1st metacarpal (HP:0010009)1.99881749
55Congenital, generalized hypertrichosis (HP:0004540)1.99459274
56Lipid accumulation in hepatocytes (HP:0006561)1.97866079
57Menorrhagia (HP:0000132)1.96622635
58Cerebral edema (HP:0002181)1.95179840
59Congenital stationary night blindness (HP:0007642)1.94812842
60Alacrima (HP:0000522)1.93677448
61Neoplasm of the tracheobronchial system (HP:0100552)1.93019655
62Aplasia/Hypoplasia of the tongue (HP:0010295)1.90939470
63Hypoplasia of the uterus (HP:0000013)1.90834976
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89945538
65Abnormality of vitamin B metabolism (HP:0004340)1.89109530
66Hypoplastic labia majora (HP:0000059)1.88773461
67Labial hypoplasia (HP:0000066)1.88552445
68Optic nerve hypoplasia (HP:0000609)1.88252279
69Increased density of long bones (HP:0006392)1.88207172
70Hepatic necrosis (HP:0002605)1.87889428
71Bile duct proliferation (HP:0001408)1.86145180
72Abnormal biliary tract physiology (HP:0012439)1.86145180
73Abnormality of renal resorption (HP:0011038)1.85958582
74Medial flaring of the eyebrow (HP:0010747)1.85239253
75Attenuation of retinal blood vessels (HP:0007843)1.84465771
76Panhypogammaglobulinemia (HP:0003139)1.83698559
77Upper limb muscle weakness (HP:0003484)1.83329803
78Chromsome breakage (HP:0040012)1.82730832
79Central scotoma (HP:0000603)1.82615277
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81624483
81Posterior subcapsular cataract (HP:0007787)1.81253921
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80148311
83Abnormality of alanine metabolism (HP:0010916)1.80148311
84Hyperalaninemia (HP:0003348)1.80148311
85Striae distensae (HP:0001065)1.79152188
86Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.78988508
87Furrowed tongue (HP:0000221)1.76111156
88Abnormality of the renal cortex (HP:0011035)1.75852147
89Hepatocellular necrosis (HP:0001404)1.74779219
90Abnormality of macular pigmentation (HP:0008002)1.74533331
91Aqueductal stenosis (HP:0002410)1.74190827
92Gingival bleeding (HP:0000225)1.73711178
93Bony spicule pigmentary retinopathy (HP:0007737)1.73590631
94Abnormality of the fovea (HP:0000493)1.73321421
95Abolished electroretinogram (ERG) (HP:0000550)1.73081243
96Septo-optic dysplasia (HP:0100842)1.72010864
97Orthostatic hypotension (HP:0001278)1.72002285
98Abnormality of the labia majora (HP:0012881)1.69108552
99Abnormality of the heme biosynthetic pathway (HP:0010472)1.67691628
100Gonadal dysgenesis (HP:0000133)1.67346264

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK16.67713698
2NME23.63650254
3NUAK13.59615072
4BUB13.39097972
5PLK42.92707830
6FRK2.90284915
7MAP4K22.42911552
8ACVR1B2.28855659
9NEK22.19182505
10EIF2AK12.06123490
11FGFR21.99840179
12BRSK21.97236222
13PLK21.96181031
14CDK191.94081814
15NTRK11.75370431
16STK161.69577541
17STK31.67518386
18WNK31.66373905
19STK241.66255444
20ZAK1.64667309
21PTK2B1.55622412
22PLK31.42807662
23LATS11.32241566
24ERBB31.32216528
25CSNK1G31.29939075
26CCNB11.28819086
27GRK11.28758656
28MST41.27721899
29TNK21.21108113
30CSNK1G11.19430252
31MELK1.18570183
32INSRR1.15602843
33PDK21.13323128
34BCKDK1.12969303
35UHMK11.05720946
36PAK31.00761127
37CSNK1G21.00234882
38NTRK20.99773818
39BMPR1B0.96955292
40ADRBK20.94794461
41CSNK1A1L0.90642460
42TEC0.90218875
43TTK0.89539903
44AKT20.87189185
45BRSK10.81500926
46VRK10.80197470
47IRAK10.77160486
48STK40.76209283
49TGFBR10.74645334
50RAF10.71362382
51MAP2K10.68131199
52GRK60.67734742
53MAP3K50.64820959
54ILK0.63781990
55TAOK30.61436970
56TSSK60.61343499
57PINK10.60538815
58MKNK10.60533259
59FER0.60392650
60PLK10.59545207
61PRKCQ0.58809889
62PNCK0.58493304
63CAMKK20.57391592
64BMX0.57320618
65MAPK130.57258846
66PRKCE0.56699846
67MAP3K120.56567697
68GRK50.52123122
69DAPK20.51278721
70LMTK20.50604492
71PRKCG0.49793091
72MINK10.49119400
73TRPM70.47122985
74BTK0.46466590
75ATM0.45938959
76TRIM280.44325482
77MKNK20.44192159
78BRD40.43258924
79WEE10.42706480
80AURKB0.42569270
81OBSCN0.38581733
82SYK0.36933649
83SGK30.35474032
84PDK10.33030376
85PHKG20.31681161
86PHKG10.31681161
87AKT30.31103658
88YES10.30563140
89CDC70.29102485
90VRK20.28045209
91CSNK1E0.25504828
92SGK20.24384849
93IGF1R0.24044905
94PRKCA0.22732224
95PRKDC0.22181890
96CSNK1D0.21937891
97TNIK0.20738689
98PRKG10.20116225
99EGFR0.18452163
100PRKAA20.18071642

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.78589396
2Steroid biosynthesis_Homo sapiens_hsa001004.16987495
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.91270360
4Fatty acid elongation_Homo sapiens_hsa000622.64963268
5Collecting duct acid secretion_Homo sapiens_hsa049662.32324651
6Oxidative phosphorylation_Homo sapiens_hsa001902.32202242
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22237472
8Sulfur metabolism_Homo sapiens_hsa009202.21011916
9Protein export_Homo sapiens_hsa030602.18886732
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.13326081
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.10170957
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01930098
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.01044092
14Parkinsons disease_Homo sapiens_hsa050121.96185063
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.67851377
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67218864
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65890123
18Non-homologous end-joining_Homo sapiens_hsa034501.65422218
19Propanoate metabolism_Homo sapiens_hsa006401.61175617
20Glutathione metabolism_Homo sapiens_hsa004801.57055484
21Nitrogen metabolism_Homo sapiens_hsa009101.56691445
22Butanoate metabolism_Homo sapiens_hsa006501.56242354
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55239921
24Fatty acid metabolism_Homo sapiens_hsa012121.53712402
25Homologous recombination_Homo sapiens_hsa034401.49939740
26Fanconi anemia pathway_Homo sapiens_hsa034601.35009301
27Peroxisome_Homo sapiens_hsa041461.33646953
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.30536079
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25013053
30Phototransduction_Homo sapiens_hsa047441.23244193
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.20811997
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17266011
33One carbon pool by folate_Homo sapiens_hsa006701.15242970
34Huntingtons disease_Homo sapiens_hsa050161.14474633
35Circadian rhythm_Homo sapiens_hsa047101.14122258
36Fat digestion and absorption_Homo sapiens_hsa049751.12222578
37Proteasome_Homo sapiens_hsa030501.11978831
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11178097
39Arginine and proline metabolism_Homo sapiens_hsa003301.10285399
40Regulation of autophagy_Homo sapiens_hsa041401.09609931
41RNA polymerase_Homo sapiens_hsa030201.09590090
42Alzheimers disease_Homo sapiens_hsa050101.07234544
43Basal transcription factors_Homo sapiens_hsa030221.07151744
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06267755
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04552034
46Selenocompound metabolism_Homo sapiens_hsa004501.03851449
47Mismatch repair_Homo sapiens_hsa034301.03254566
48Vitamin digestion and absorption_Homo sapiens_hsa049771.03099759
49Glycerolipid metabolism_Homo sapiens_hsa005610.98007657
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96086011
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91776697
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.90109440
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88292179
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86991624
55Fatty acid degradation_Homo sapiens_hsa000710.84732222
56RNA degradation_Homo sapiens_hsa030180.82070428
57Pyruvate metabolism_Homo sapiens_hsa006200.77280755
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76701020
59Metabolic pathways_Homo sapiens_hsa011000.76091230
60Chemical carcinogenesis_Homo sapiens_hsa052040.74666861
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73046171
62Serotonergic synapse_Homo sapiens_hsa047260.70654224
63Synaptic vesicle cycle_Homo sapiens_hsa047210.70360250
64Sphingolipid metabolism_Homo sapiens_hsa006000.70042150
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69307553
66Tryptophan metabolism_Homo sapiens_hsa003800.68107487
67Cardiac muscle contraction_Homo sapiens_hsa042600.59713425
68Folate biosynthesis_Homo sapiens_hsa007900.59362268
69Arginine biosynthesis_Homo sapiens_hsa002200.58363604
70Hedgehog signaling pathway_Homo sapiens_hsa043400.55600139
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54358287
72Vibrio cholerae infection_Homo sapiens_hsa051100.54284212
73Insulin secretion_Homo sapiens_hsa049110.53957120
74Purine metabolism_Homo sapiens_hsa002300.51499612
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46329624
76Arachidonic acid metabolism_Homo sapiens_hsa005900.46207660
77African trypanosomiasis_Homo sapiens_hsa051430.44665121
78Platelet activation_Homo sapiens_hsa046110.44406733
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41854188
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40623345
81Retinol metabolism_Homo sapiens_hsa008300.39893110
82Spliceosome_Homo sapiens_hsa030400.38770259
83RNA transport_Homo sapiens_hsa030130.38244329
84Taste transduction_Homo sapiens_hsa047420.37492227
85Linoleic acid metabolism_Homo sapiens_hsa005910.37252769
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35061734
87Dorso-ventral axis formation_Homo sapiens_hsa043200.34976790
88Calcium signaling pathway_Homo sapiens_hsa040200.32689220
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31477045
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29814960
91Nucleotide excision repair_Homo sapiens_hsa034200.27331292
92Olfactory transduction_Homo sapiens_hsa047400.24715126
93Circadian entrainment_Homo sapiens_hsa047130.23851402
94Type I diabetes mellitus_Homo sapiens_hsa049400.23280626
95Long-term depression_Homo sapiens_hsa047300.21548437
96Alcoholism_Homo sapiens_hsa050340.21070518
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.20602407
98TGF-beta signaling pathway_Homo sapiens_hsa043500.19742264
99Carbon metabolism_Homo sapiens_hsa012000.18411297
100PPAR signaling pathway_Homo sapiens_hsa033200.17024739

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