UNKL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a RING finger protein that may function in Rac signaling. It can bind to Brg/Brm-associated factor 60b and can promote its ubiquitination. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.10057603
2protein kinase C signaling (GO:0070528)4.74370046
3positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.74078101
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.73066796
5sodium ion export (GO:0071436)4.67053876
6locomotory exploration behavior (GO:0035641)4.51900146
7regulation of DNA methylation (GO:0044030)4.46934592
8regulation of female gonad development (GO:2000194)4.31648612
9negative regulation of erythrocyte differentiation (GO:0045647)4.18977501
10negative regulation of histone methylation (GO:0031061)4.15624768
11histone H3-K36 demethylation (GO:0070544)4.12450912
12synaptic vesicle exocytosis (GO:0016079)4.12231462
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.07857366
14glutamate secretion (GO:0014047)4.04813824
15regulation of chromatin binding (GO:0035561)4.03927248
16negative regulation of cAMP-mediated signaling (GO:0043951)4.02233670
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.97597181
18histone H3-K4 methylation (GO:0051568)3.97414908
19cellular potassium ion homeostasis (GO:0030007)3.81155278
20regulation of acrosome reaction (GO:0060046)3.78624524
21cerebellar Purkinje cell differentiation (GO:0021702)3.75081441
22neurotransmitter secretion (GO:0007269)3.73631295
23histone H3-K4 trimethylation (GO:0080182)3.70878269
24regulation of synaptic vesicle exocytosis (GO:2000300)3.70100578
25oocyte development (GO:0048599)3.69775740
26negative regulation of cell killing (GO:0031342)3.65483943
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.65483943
28synaptic vesicle docking involved in exocytosis (GO:0016081)3.62700639
29activation of protein kinase A activity (GO:0034199)3.62674928
30regulation of gamma-delta T cell differentiation (GO:0045586)3.57850646
31positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.55988424
32negative T cell selection (GO:0043383)3.48398381
33regulation of ARF protein signal transduction (GO:0032012)3.46601387
34vocalization behavior (GO:0071625)3.45811470
35regulation of neuronal synaptic plasticity (GO:0048168)3.45795898
36multicellular organism reproduction (GO:0032504)3.44892771
37positive regulation by symbiont of host defense response (GO:0052509)3.44789473
38modulation by symbiont of host defense response (GO:0052031)3.44789473
39modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.44789473
40modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.44789473
41positive regulation by organism of defense response of other organism involved in symbiotic interact3.44789473
42modulation by symbiont of host immune response (GO:0052553)3.44789473
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.39825819
44cytoskeletal anchoring at plasma membrane (GO:0007016)3.38668204
45positive T cell selection (GO:0043368)3.38342743
46layer formation in cerebral cortex (GO:0021819)3.36766576
47neuromuscular process controlling posture (GO:0050884)3.36687451
48intracellular estrogen receptor signaling pathway (GO:0030520)3.36605381
49negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.36597122
50positive regulation of synapse maturation (GO:0090129)3.36462914
51mannose metabolic process (GO:0006013)3.36371339
52positive regulation of gene expression, epigenetic (GO:0045815)3.33675820
53positive regulation of CREB transcription factor activity (GO:0032793)3.32714448
54positive regulation of humoral immune response (GO:0002922)3.29987452
55regulation of glutamate receptor signaling pathway (GO:1900449)3.29857157
56positive regulation of gamma-delta T cell activation (GO:0046645)3.29126448
57histone H3-K9 modification (GO:0061647)3.28286765
58positive regulation of histone deacetylation (GO:0031065)3.27806756
59prepulse inhibition (GO:0060134)3.26888068
60gamma-aminobutyric acid transport (GO:0015812)3.25904541
61histone lysine demethylation (GO:0070076)3.25263358
62dicarboxylic acid biosynthetic process (GO:0043650)3.24277033
63neuromuscular process controlling balance (GO:0050885)3.23853065
64DNA methylation involved in gamete generation (GO:0043046)3.23558059
65regulation of long-term neuronal synaptic plasticity (GO:0048169)3.20014065
66negative thymic T cell selection (GO:0045060)3.19444426
67negative regulation of histone acetylation (GO:0035067)3.16785669
68regulation of clathrin-mediated endocytosis (GO:2000369)3.15650931
69histone demethylation (GO:0016577)3.14560437
70histone H3-K9 demethylation (GO:0033169)3.14075204
71regulation of synaptic vesicle transport (GO:1902803)3.12560575
72positive thymic T cell selection (GO:0045059)3.11787341
73potassium ion import (GO:0010107)3.10723047
74macrophage activation involved in immune response (GO:0002281)3.06849459
75thymic T cell selection (GO:0045061)3.05310018
76exploration behavior (GO:0035640)3.03319637
77ionotropic glutamate receptor signaling pathway (GO:0035235)3.01085526
78regulation of gamma-delta T cell activation (GO:0046643)3.00509670
79regulation of histone H3-K4 methylation (GO:0051569)3.00276868
80peptidyl-arginine modification (GO:0018195)2.95987426
81regulation of cholesterol homeostasis (GO:2000188)2.94238354
82negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.93965766
83T cell selection (GO:0045058)2.93472084
84DNA methylation (GO:0006306)2.93160942
85DNA alkylation (GO:0006305)2.93160942
86regulation of synapse structural plasticity (GO:0051823)2.93032174
87long-term memory (GO:0007616)2.90960230
88positive regulation of protein deacetylation (GO:0090312)2.90765937
89histone H3-K9 methylation (GO:0051567)2.90265287
90neuronal action potential propagation (GO:0019227)2.85817790
91antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.84824082
92response to muramyl dipeptide (GO:0032495)2.84122107
93signal complex assembly (GO:0007172)2.83286547
94negative regulation of histone modification (GO:0031057)2.83274850
95gene silencing (GO:0016458)2.80669732
96synaptic vesicle endocytosis (GO:0048488)2.79143194
97histone lysine methylation (GO:0034968)2.79020305
98establishment of nucleus localization (GO:0040023)2.78964469
99response to peptidoglycan (GO:0032494)2.78719742
100histone H4 deacetylation (GO:0070933)2.78628414
101leukocyte aggregation (GO:0070486)2.77530315
102protein dealkylation (GO:0008214)2.77505725
103protein demethylation (GO:0006482)2.77505725
104antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77483366
105response to pheromone (GO:0019236)2.77413338
106regulation of interferon-beta biosynthetic process (GO:0045357)2.75942628
107regulation of histone H3-K9 methylation (GO:0051570)2.75112694
108neurotransmitter transport (GO:0006836)2.74213016
109regulation of ARF GTPase activity (GO:0032312)2.73914975
110regulation of neurotransmitter levels (GO:0001505)2.72617969
111positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.72411600
112citrulline biosynthetic process (GO:0019240)2.70770448
113negative regulation of peptidyl-lysine acetylation (GO:2000757)2.70752236
114positive regulation of fibroblast migration (GO:0010763)2.69997340
115cellular sodium ion homeostasis (GO:0006883)2.68908782
116pre-miRNA processing (GO:0031054)2.68830442
117neurotransmitter-gated ion channel clustering (GO:0072578)2.68058439
118histone H4-K16 acetylation (GO:0043984)2.66614639
119snRNA metabolic process (GO:0016073)2.66466773
120neuronal ion channel clustering (GO:0045161)2.66296772
121regulation of histone methylation (GO:0031060)2.65877649
122regulation of mast cell degranulation (GO:0043304)2.65848901
123cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.64883636
124N-terminal protein amino acid acetylation (GO:0006474)2.64120033
125regulation of synaptic plasticity (GO:0048167)2.63969237
126cell migration in hindbrain (GO:0021535)2.61987514
127T cell homeostasis (GO:0043029)2.60941949
128phosphatidylinositol dephosphorylation (GO:0046856)2.60660489
129germinal center formation (GO:0002467)2.59527414
1303-UTR-mediated mRNA stabilization (GO:0070935)2.59125561
131synaptic transmission, glutamatergic (GO:0035249)2.58629996
132response to interleukin-15 (GO:0070672)2.58085854
133positive regulation of membrane potential (GO:0045838)2.57067820
134protein localization to synapse (GO:0035418)2.56443183
135membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.56371298
136lysine catabolic process (GO:0006554)2.56205253
137lysine metabolic process (GO:0006553)2.56205253
138regulation of type I interferon-mediated signaling pathway (GO:0060338)2.55918869
139cellular response to virus (GO:0098586)2.55793740
140glycine transport (GO:0015816)2.55302605
141dendritic spine morphogenesis (GO:0060997)2.55121867
142positive regulation of Cdc42 GTPase activity (GO:0043089)2.54880756
143antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.54825727
144piRNA metabolic process (GO:0034587)2.54346206
145histone phosphorylation (GO:0016572)2.52533692
146positive regulation of B cell differentiation (GO:0045579)2.50686689
147regulation of dendritic spine morphogenesis (GO:0061001)2.50362159
148cell communication by electrical coupling (GO:0010644)2.50336080
149potassium ion homeostasis (GO:0055075)2.49740160
150positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.49645036
151glutamate metabolic process (GO:0006536)2.49553002
152glutamate receptor signaling pathway (GO:0007215)2.49389458
153positive regulation of dendritic spine morphogenesis (GO:0061003)2.48397327
154membrane depolarization during action potential (GO:0086010)2.47794269
155regulation of excitatory postsynaptic membrane potential (GO:0060079)2.47611489
156negative regulation of viral release from host cell (GO:1902187)2.47064095
157mitotic chromosome condensation (GO:0007076)2.46720076
158proline transport (GO:0015824)2.45963062
159positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.45478456
160negative regulation of interleukin-12 production (GO:0032695)2.45284431
161B cell receptor signaling pathway (GO:0050853)2.44804066
162regulation of histone acetylation (GO:0035065)2.44601255
163cell-cell junction maintenance (GO:0045217)2.44359425
164chromatin silencing (GO:0006342)2.44142325
165response to auditory stimulus (GO:0010996)2.43434010
166negative regulation of chromatin modification (GO:1903309)2.42934544
167negative regulation of innate immune response (GO:0045824)2.42105325
168regulation of translational termination (GO:0006449)2.41917474
169vesicle transport along microtubule (GO:0047496)2.41910584
170neuron-neuron synaptic transmission (GO:0007270)2.41300363
171histone methylation (GO:0016571)2.41223469
172gene silencing by RNA (GO:0031047)2.41057932
173antigen processing and presentation of endogenous antigen (GO:0019883)2.41009888
174cAMP biosynthetic process (GO:0006171)2.40964956
175G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.40892861
176regulation of mast cell activation involved in immune response (GO:0033006)2.39240911
177stress granule assembly (GO:0034063)2.39175969
178neuromuscular process (GO:0050905)2.39051099
179regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.38963404
180auditory behavior (GO:0031223)2.38565818
181regulation of sodium ion transmembrane transporter activity (GO:2000649)2.35180834
182positive regulation of sodium ion transport (GO:0010765)2.35165927
183CDP-diacylglycerol metabolic process (GO:0046341)2.35058304
184regulation of postsynaptic membrane potential (GO:0060078)2.31814295
185regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.30431351

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human4.10389746
2VDR_21846776_ChIP-Seq_THP-1_Human3.84861003
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.28646738
4TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.79878079
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.75418458
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.64401158
7MYC_22102868_ChIP-Seq_BL_Human2.49789831
8DROSHA_22980978_ChIP-Seq_HELA_Human2.47368845
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.46663863
10* KDM2B_26808549_Chip-Seq_DND41_Human2.43471193
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43096103
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.41761622
13KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.22045431
14EZH2_22144423_ChIP-Seq_EOC_Human2.20172859
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.13785332
16VDR_24763502_ChIP-Seq_THP-1_Human2.11925407
17KDM2B_26808549_Chip-Seq_K562_Human2.11090557
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10728561
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06501511
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.04741621
21ZFP281_18757296_ChIP-ChIP_E14_Mouse2.02889773
22* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.99402878
23* KDM2B_26808549_Chip-Seq_JURKAT_Human1.91943114
24TCF7_22412390_ChIP-Seq_EML_Mouse1.91841636
25* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.86940526
26REST_21632747_ChIP-Seq_MESCs_Mouse1.85521826
27GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.85069902
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.84562701
29LXR_22292898_ChIP-Seq_THP-1_Human1.72597085
30ZFP281_27345836_Chip-Seq_ESCs_Mouse1.72156725
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71383115
32* BCOR_27268052_Chip-Seq_Bcells_Human1.71035483
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.70957540
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.70757934
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.68864957
36RUNX_20019798_ChIP-Seq_JUKART_Human1.67835577
37SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.63292145
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62779405
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.62777930
40GATA1_19941826_ChIP-Seq_K562_Human1.60871252
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59937031
42* BCL6_27268052_Chip-Seq_Bcells_Human1.55800616
43DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55653948
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54442272
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53703345
46NCOR1_26117541_ChIP-Seq_K562_Human1.53556232
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.53554808
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53431365
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52729927
50* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52381371
51SCL_19346495_ChIP-Seq_HPC-7_Human1.51154534
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50928289
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50548355
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.50186239
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49242624
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47692054
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47692054
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47350537
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.47324729
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47237680
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.46864130
62* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45331263
63ZNF263_19887448_ChIP-Seq_K562_Human1.44836096
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43693336
65CIITA_25753668_ChIP-Seq_RAJI_Human1.43095331
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.42001136
67LXR_22158963_ChIP-Seq_LIVER_Mouse1.41797392
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41353298
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41121617
70PKCTHETA_26484144_Chip-Seq_BREAST_Human1.40578379
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39993719
72PHF8_20622854_ChIP-Seq_HELA_Human1.38492315
73CREB1_26743006_Chip-Seq_LNCaP_Human1.37872705
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37639219
75* ESR2_21235772_ChIP-Seq_MCF-7_Human1.36774031
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35879585
77UTX_26944678_Chip-Seq_JUKART_Human1.35113860
78E2F1_20622854_ChIP-Seq_HELA_Human1.34853406
79TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.33366217
80MAF_26560356_Chip-Seq_TH1_Human1.32829883
81SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.32195273
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31376063
83AR_21572438_ChIP-Seq_LNCaP_Human1.30920171
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30688423
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30321520
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30018857
87MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.28148152
88* SMC4_20622854_ChIP-Seq_HELA_Human1.25335756
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.25124243
90* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.23757398
91SPI1_23127762_ChIP-Seq_K562_Human1.22684688
92JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22327295
93* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21894094
94FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21548658
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.20345135
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20314182
97FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20115348
98CTCF_21964334_Chip-Seq_Bcells_Human1.17630406
99CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17296425
100RNF2_27304074_Chip-Seq_ESCs_Mouse1.16550274
101MYB_26560356_Chip-Seq_TH1_Human1.16238095
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15041710
103TET1_21490601_ChIP-Seq_MESCs_Mouse1.14658512
104ETS1_21867929_ChIP-Seq_TH2_Mouse1.14326941
105CTCF_26484167_Chip-Seq_Bcells_Mouse1.14030096
106WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13459713
107* ELK3_25401928_ChIP-Seq_HUVEC_Human1.12260866
108SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11728028
109EZH2_27294783_Chip-Seq_ESCs_Mouse1.11524263
110* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10835784
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09918161
112P68_20966046_ChIP-Seq_HELA_Human1.08693311
113TP63_22573176_ChIP-Seq_HFKS_Human1.07986691
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07912524
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07796600
116RACK7_27058665_Chip-Seq_MCF-7_Human1.06955745
117KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06800971
118KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06800971
119KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06800971
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06417907
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05687880
122UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05035505
123AR_19668381_ChIP-Seq_PC3_Human1.04981932
124FOXA2_19822575_ChIP-Seq_HepG2_Human1.03767292
125RXR_22108803_ChIP-Seq_LS180_Human1.02680406
126YY1_22570637_ChIP-Seq_MALME-3M_Human1.02120882
127RARB_24833708_ChIP-Seq_LIVER_Mouse1.02115447
128SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01422014
129SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01381096
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00616399
131ESR1_20079471_ChIP-ChIP_T-47D_Human1.00386985
132RARA_24833708_ChIP-Seq_LIVER_Mouse1.00311505
133CTCF_27219007_Chip-Seq_Bcells_Human0.99786137
134CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98840658
135EGR1_19374776_ChIP-ChIP_THP-1_Human0.98838580
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98107944
137RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97750864
138SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96353728
139CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96123860
140SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95884225
141KLF4_19829295_ChIP-Seq_ESCs_Human0.95636659
142GATA2_19941826_ChIP-Seq_K562_Human0.92325455
143OCT4_19829295_ChIP-Seq_ESCs_Human0.91754249
144CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91538869
145TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.91317548
146CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90413848
147RUNX1_27514584_Chip-Seq_MCF-7_Human0.90381659
148MAF_26560356_Chip-Seq_TH2_Human0.89436977
149SOX2_21211035_ChIP-Seq_LN229_Gbm0.88737944
150SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.88716983
151RING1B_27294783_Chip-Seq_ESCs_Mouse0.88622333

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.63768724
2MP0002822_catalepsy4.77172238
3MP0009278_abnormal_bone_marrow3.51855157
4MP0003635_abnormal_synaptic_transmissio3.48847656
5MP0005076_abnormal_cell_differentiation3.37498489
6MP0005423_abnormal_somatic_nervous2.75902686
7MP0009046_muscle_twitch2.72420916
8MP0008260_abnormal_autophagy2.71421629
9MP0009745_abnormal_behavioral_response2.70725302
10MP0003436_decreased_susceptibility_to2.68054617
11MP0002063_abnormal_learning/memory/cond2.63744403
12MP0004270_analgesia2.60372043
13MP0005451_abnormal_body_composition2.59174191
14MP0002064_seizures2.57927851
15MP0003183_abnormal_peptide_metabolism2.55044334
16MP0003880_abnormal_central_pattern2.41763773
17MP0005360_urolithiasis2.31641726
18MP0003329_amyloid_beta_deposits2.29011469
19MP0003724_increased_susceptibility_to2.27484087
20MP0001968_abnormal_touch/_nociception2.27417066
21MP0008961_abnormal_basal_metabolism2.25326583
22MP0002139_abnormal_hepatobiliary_system2.18010109
23MP0008569_lethality_at_weaning2.14894985
24MP0002396_abnormal_hematopoietic_system2.11229762
25MP0002572_abnormal_emotion/affect_behav2.04200181
26MP0004185_abnormal_adipocyte_glucose2.01625066
27MP0000685_abnormal_immune_system1.99940885
28MP0002249_abnormal_larynx_morphology1.96993979
29MP0001486_abnormal_startle_reflex1.94691984
30MP0003718_maternal_effect1.91084452
31MP0004381_abnormal_hair_follicle1.90250674
32MP0004885_abnormal_endolymph1.88188603
33MP0002138_abnormal_hepatobiliary_system1.85396990
34MP0002272_abnormal_nervous_system1.85277563
35MP0000678_abnormal_parathyroid_gland1.84061580
36MP0001986_abnormal_taste_sensitivity1.82773568
37MP0004811_abnormal_neuron_physiology1.79252095
38MP0002733_abnormal_thermal_nociception1.78844923
39MP0002735_abnormal_chemical_nociception1.76698940
40MP0001440_abnormal_grooming_behavior1.74373051
41MP0005365_abnormal_bile_salt1.68118655
42MP0005085_abnormal_gallbladder_physiolo1.66928106
43MP0001800_abnormal_humoral_immune1.66407610
44MP0001348_abnormal_lacrimal_gland1.65952849
45MP0002736_abnormal_nociception_after1.63543493
46MP0003656_abnormal_erythrocyte_physiolo1.62753325
47MP0001501_abnormal_sleep_pattern1.57137534
48MP0003693_abnormal_embryo_hatching1.55843977
49MP0009333_abnormal_splenocyte_physiolog1.52697731
50MP0003111_abnormal_nucleus_morphology1.52668919
51MP0001970_abnormal_pain_threshold1.51556743
52MP0002734_abnormal_mechanical_nocicepti1.51251812
53MP0002419_abnormal_innate_immunity1.48936680
54MP0002909_abnormal_adrenal_gland1.48236654
55MP0008874_decreased_physiological_sensi1.47346959
56MP0002420_abnormal_adaptive_immunity1.45282051
57MP0010234_abnormal_vibrissa_follicle1.43043998
58MP0001819_abnormal_immune_cell1.42375809
59MP0003633_abnormal_nervous_system1.40687622
60MP0004858_abnormal_nervous_system1.39425213
61MP0002132_abnormal_respiratory_system1.39348690
62MP0010329_abnormal_lipoprotein_level1.38294089
63MP0002067_abnormal_sensory_capabilities1.37609154
64MP0008872_abnormal_physiological_respon1.37586943
65MP0005386_behavior/neurological_phenoty1.36246922
66MP0004924_abnormal_behavior1.36246922
67MP0000470_abnormal_stomach_morphology1.36043783
68MP0002722_abnormal_immune_system1.35233369
69MP0002723_abnormal_immune_serum1.34845777
70MP0002184_abnormal_innervation1.34595889
71MP0000604_amyloidosis1.33821832
72MP0008877_abnormal_DNA_methylation1.32195848
73MP0003699_abnormal_female_reproductive1.29958668
74MP0003763_abnormal_thymus_physiology1.29565306
75MP0005083_abnormal_biliary_tract1.26888971
76MP0000716_abnormal_immune_system1.26614470
77MP0003300_gastrointestinal_ulcer1.25784081
78MP0002452_abnormal_antigen_presenting1.25268409
79MP0000955_abnormal_spinal_cord1.24514011
80MP0000750_abnormal_muscle_regeneration1.22561523
81MP0000689_abnormal_spleen_morphology1.22284424
82MP0000003_abnormal_adipose_tissue1.20586888
83MP0001545_abnormal_hematopoietic_system1.20459927
84MP0005397_hematopoietic_system_phenotyp1.20459927
85MP0004808_abnormal_hematopoietic_stem1.20192570
86MP0002653_abnormal_ependyma_morphology1.19928421
87MP0001790_abnormal_immune_system1.19747896
88MP0005387_immune_system_phenotype1.19747896
89MP0005310_abnormal_salivary_gland1.19314910
90MP0008875_abnormal_xenobiotic_pharmacok1.18286184
91MP0002254_reproductive_system_inflammat1.17599555
92MP0003631_nervous_system_phenotype1.17062184
93MP0008995_early_reproductive_senescence1.16497021
94MP0008057_abnormal_DNA_replication1.16000450
95MP0003879_abnormal_hair_cell1.15870773
96MP0005025_abnormal_response_to1.14019091
97MP0001730_embryonic_growth_arrest1.13987191
98MP0002066_abnormal_motor_capabilities/c1.13532954
99MP0005000_abnormal_immune_tolerance1.13035799
100MP0000733_abnormal_muscle_development1.12033616
101MP0005409_darkened_coat_color1.10792598
102MP0002429_abnormal_blood_cell1.10157907
103MP0002405_respiratory_system_inflammati1.07616286
104MP0003172_abnormal_lysosome_physiology1.06907132
105MP0005670_abnormal_white_adipose1.03365760
106MP0002557_abnormal_social/conspecific_i1.00644116
107MP0002928_abnormal_bile_duct1.00008401
108MP0003077_abnormal_cell_cycle0.96796192
109MP0005375_adipose_tissue_phenotype0.96690852
110MP0003690_abnormal_glial_cell0.96429256
111MP0001502_abnormal_circadian_rhythm0.96427536
112MP0001849_ear_inflammation0.95914719
113MP0009780_abnormal_chondrocyte_physiolo0.95467218
114MP0000778_abnormal_nervous_system0.95067242
115MP0002882_abnormal_neuron_morphology0.94468345
116MP0005535_abnormal_body_temperature0.93241776
117MP0004147_increased_porphyrin_level0.93103861
118MP0003045_fibrosis0.92702562
119MP0003632_abnormal_nervous_system0.91647331
120MP0003075_altered_response_to0.91285041
121MP0003453_abnormal_keratinocyte_physiol0.90715870
122MP0002210_abnormal_sex_determination0.90314639
123MP0002069_abnormal_eating/drinking_beha0.89115350
124MP0000609_abnormal_liver_physiology0.88998027
125MP0000703_abnormal_thymus_morphology0.88669291
126MP0002019_abnormal_tumor_incidence0.88378326
127MP0001929_abnormal_gametogenesis0.88145339
128MP0000747_muscle_weakness0.88043749
129MP0002166_altered_tumor_susceptibility0.87355472
130MP0003866_abnormal_defecation0.85972134
131MP0005666_abnormal_adipose_tissue0.85421209
132MP0001919_abnormal_reproductive_system0.84777061
133MP0001533_abnormal_skeleton_physiology0.84724076
134MP0002152_abnormal_brain_morphology0.84354244
135MP0003878_abnormal_ear_physiology0.83327799
136MP0005377_hearing/vestibular/ear_phenot0.83327799
137MP0005395_other_phenotype0.82662758
138MP0000313_abnormal_cell_death0.82588904
139MP0000569_abnormal_digit_pigmentation0.81270100
140MP0003252_abnormal_bile_duct0.80459609
141MP0002089_abnormal_postnatal_growth/wei0.80235304
142MP0008770_decreased_survivor_rate0.78728129
143MP0005332_abnormal_amino_acid0.78361145
144MP0003787_abnormal_imprinting0.78275439
145MP0002970_abnormal_white_adipose0.78226804
146MP0005646_abnormal_pituitary_gland0.77862760
147MP0004142_abnormal_muscle_tone0.77813340
148MP0003705_abnormal_hypodermis_morpholog0.76804162
149MP0005621_abnormal_cell_physiology0.76534292
150MP0002161_abnormal_fertility/fecundity0.76515003
151MP0004130_abnormal_muscle_cell0.74855512
152MP0010307_abnormal_tumor_latency0.74766780
153MP0005623_abnormal_meninges_morphology0.73615608
154MP0003091_abnormal_cell_migration0.73420118
155MP0010094_abnormal_chromosome_stability0.71943328
156MP0001529_abnormal_vocalization0.71773884
157MP0004233_abnormal_muscle_weight0.71744090
158MP0001873_stomach_inflammation0.71537259
159MP0005584_abnormal_enzyme/coenzyme_acti0.70610787
160MP0002229_neurodegeneration0.70605519
161MP0000920_abnormal_myelination0.70439771
162MP0009840_abnormal_foam_cell0.69350532
163MP0000759_abnormal_skeletal_muscle0.69292246
164MP0000350_abnormal_cell_proliferation0.69270736
165MP0005334_abnormal_fat_pad0.68287493
166MP0004947_skin_inflammation0.67550508
167MP0001984_abnormal_olfaction0.67206478
168MP0010769_abnormal_survival0.66851997
169MP0002398_abnormal_bone_marrow0.66465273
170MP0002118_abnormal_lipid_homeostasis0.65543189
171MP0002277_abnormal_respiratory_mucosa0.64711204
172MP0005166_decreased_susceptibility_to0.64465344
173MP0005671_abnormal_response_to0.64027572
174MP0005174_abnormal_tail_pigmentation0.63602335
175MP0003303_peritoneal_inflammation0.63150570
176MP0000653_abnormal_sex_gland0.63136685
177MP0010768_mortality/aging0.63072791
178MP0001765_abnormal_ion_homeostasis0.59614449
179MP0010770_preweaning_lethality0.58256416

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.43118479
2Myokymia (HP:0002411)4.33505491
3Focal seizures (HP:0007359)4.31968608
4Focal motor seizures (HP:0011153)4.27117384
5Abnormality of the lower motor neuron (HP:0002366)3.72495340
6Dysmetric saccades (HP:0000641)3.65961294
7Action tremor (HP:0002345)3.44568351
8Eczematoid dermatitis (HP:0000976)3.41522626
9Visual hallucinations (HP:0002367)3.37959417
10Impaired social interactions (HP:0000735)3.30998457
11Abnormal social behavior (HP:0012433)3.30998457
12Hemiplegia (HP:0002301)3.11449208
13Annular pancreas (HP:0001734)3.03311706
14Gastrointestinal infarctions (HP:0005244)3.03002993
15Myositis (HP:0100614)3.02848992
16Homocystinuria (HP:0002156)3.01420798
17Abnormality of homocysteine metabolism (HP:0010919)3.01420798
18Poor eye contact (HP:0000817)2.93333530
19Febrile seizures (HP:0002373)2.84906300
20Urinary urgency (HP:0000012)2.84770884
21Postural instability (HP:0002172)2.83577158
22Orchitis (HP:0100796)2.78737742
23Impulsivity (HP:0100710)2.77951841
24Recurrent fungal infections (HP:0002841)2.77135566
25Abnormal eating behavior (HP:0100738)2.75101585
26Truncal ataxia (HP:0002078)2.72915279
27Hypochromic anemia (HP:0001931)2.71715156
28Spontaneous hematomas (HP:0007420)2.70070073
29Intention tremor (HP:0002080)2.69349747
30Impaired smooth pursuit (HP:0007772)2.68550831
31Urinary bladder sphincter dysfunction (HP:0002839)2.66591746
32Status epilepticus (HP:0002133)2.66158314
33Gout (HP:0001997)2.65103605
34Abnormality of the columella (HP:0009929)2.63145100
35Dysdiadochokinesis (HP:0002075)2.61669017
36Abnormality of the phalanges of the hallux (HP:0010057)2.61667398
37Panhypogammaglobulinemia (HP:0003139)2.61640641
38Ankle clonus (HP:0011448)2.61084161
39Deep venous thrombosis (HP:0002625)2.60461518
40Ulnar bowing (HP:0003031)2.57829114
41Atonic seizures (HP:0010819)2.57275528
42Optic neuritis (HP:0100653)2.57023088
43Retrobulbar optic neuritis (HP:0100654)2.57023088
44Recurrent abscess formation (HP:0002722)2.56557941
45Impaired vibration sensation in the lower limbs (HP:0002166)2.55956005
46Absence seizures (HP:0002121)2.55416124
47Rectal prolapse (HP:0002035)2.53937547
48Tetraplegia (HP:0002445)2.52349519
49Resting tremor (HP:0002322)2.51732457
50Supranuclear gaze palsy (HP:0000605)2.51231291
51Abnormality of ocular smooth pursuit (HP:0000617)2.49203692
52Lip pit (HP:0100267)2.48111310
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46493213
54Truncal obesity (HP:0001956)2.46450901
55Fatigue (HP:0012378)2.46405290
56Lower limb amyotrophy (HP:0007210)2.44228399
57Progressive cerebellar ataxia (HP:0002073)2.44167506
58Abnormality of macrophages (HP:0004311)2.43203503
59Spastic gait (HP:0002064)2.42943208
60Generalized tonic-clonic seizures (HP:0002069)2.42228150
61Depression (HP:0000716)2.40654850
62Dialeptic seizures (HP:0011146)2.38385238
63Dysmetria (HP:0001310)2.38347656
64Facial hemangioma (HP:0000329)2.36876675
65Turricephaly (HP:0000262)2.36243645
66Gaze-evoked nystagmus (HP:0000640)2.35644246
67Recurrent bacterial skin infections (HP:0005406)2.34708986
68Insomnia (HP:0100785)2.34324106
69Epileptic encephalopathy (HP:0200134)2.32173668
70Persistence of primary teeth (HP:0006335)2.31583455
71Anorexia (HP:0002039)2.31012509
72Hypoplasia of the thymus (HP:0000778)2.30710315
73Testicular atrophy (HP:0000029)2.27022343
74T lymphocytopenia (HP:0005403)2.26477363
75Long palpebral fissure (HP:0000637)2.23900413
76Macroorchidism (HP:0000053)2.21568795
77Broad-based gait (HP:0002136)2.21073722
78Papilledema (HP:0001085)2.19236372
79Pustule (HP:0200039)2.19107911
80Distal lower limb amyotrophy (HP:0008944)2.18690546
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17850787
82Polycythemia (HP:0001901)2.17641550
83Shallow orbits (HP:0000586)2.16470040
84Broad face (HP:0000283)2.16421446
85Hyperacusis (HP:0010780)2.14862202
86Genetic anticipation (HP:0003743)2.14372649
87Bowel incontinence (HP:0002607)2.13880472
88Disproportionate tall stature (HP:0001519)2.13371758
89Thin bony cortex (HP:0002753)2.13351756
90Ventricular fibrillation (HP:0001663)2.12265482
91Meningitis (HP:0001287)2.11924592
92Torticollis (HP:0000473)2.10954712
93Neoplasm of the heart (HP:0100544)2.10761186
94Slow saccadic eye movements (HP:0000514)2.10666373
95Attenuation of retinal blood vessels (HP:0007843)2.10310146
96Abnormality of the fingertips (HP:0001211)2.09936282
97Heterotopia (HP:0002282)2.09672805
98Capillary hemangiomas (HP:0005306)2.06413446
99Clonus (HP:0002169)2.06085444
100Pointed chin (HP:0000307)2.05510665
101Abnormality of T cell number (HP:0011839)2.03834342
102Bradykinesia (HP:0002067)2.00838396
103Bundle branch block (HP:0011710)2.00130151
104Scanning speech (HP:0002168)1.99693943
105Hypercortisolism (HP:0001578)1.99268641
106Poikilocytosis (HP:0004447)1.98584268
107Cholecystitis (HP:0001082)1.98448614
108Abnormal gallbladder physiology (HP:0012438)1.98448614
109Chronic mucocutaneous candidiasis (HP:0002728)1.97753866
110Recurrent cutaneous fungal infections (HP:0011370)1.97753866
111Abnormality of the Achilles tendon (HP:0005109)1.97671296
112Cellulitis (HP:0100658)1.95806206
113Increased connective tissue (HP:0009025)1.95499731
114Abnormal large intestine physiology (HP:0012700)1.95295127
115Stereotypic behavior (HP:0000733)1.95195239
116Global brain atrophy (HP:0002283)1.94410959
117Insidious onset (HP:0003587)1.94329746
118Termporal pattern (HP:0011008)1.94329746
119Urethral obstruction (HP:0000796)1.93357243
120Spastic diplegia (HP:0001264)1.92121521
121Basal cell carcinoma (HP:0002671)1.91800659
122Papilloma (HP:0012740)1.89019580
123Verrucae (HP:0200043)1.89019580
124Diplopia (HP:0000651)1.86661634
125Abnormality of binocular vision (HP:0011514)1.86661634
126Upper limb amyotrophy (HP:0009129)1.86464047
127Distal upper limb amyotrophy (HP:0007149)1.86464047
128Abnormality of saccadic eye movements (HP:0000570)1.86225462
129Abnormality of oral frenula (HP:0000190)1.86119083
130Spastic tetraparesis (HP:0001285)1.86020890
131Subacute progressive viral hepatitis (HP:0006572)1.85754722
132Cerebral inclusion bodies (HP:0100314)1.85692418
133Anxiety (HP:0000739)1.85548577
134Hypertriglyceridemia (HP:0002155)1.85422005
135Abnormality of the periventricular white matter (HP:0002518)1.85195829
136Generalized hypotonia (HP:0001290)1.83959632
137Focal dystonia (HP:0004373)1.83854221
138Aplasia/Hypoplasia of the thymus (HP:0010515)1.83775018
139Abnormal delayed hypersensitivity skin test (HP:0002963)1.83318477
140Increased serum ferritin (HP:0003281)1.83306056
141Myopathic facies (HP:0002058)1.82974030
142Stridor (HP:0010307)1.82498302
143Hyperglycinemia (HP:0002154)1.82145609
144Long eyelashes (HP:0000527)1.81627604
145Amyotrophic lateral sclerosis (HP:0007354)1.81033744
146Impaired vibratory sensation (HP:0002495)1.80496050
147Severe visual impairment (HP:0001141)1.80042563
148Cafe-au-lait spot (HP:0000957)1.80022120
149Abnormality of the corticospinal tract (HP:0002492)1.79783162
150Obsessive-compulsive behavior (HP:0000722)1.79398461
151Pseudobulbar signs (HP:0002200)1.78980486
152Entropion (HP:0000621)1.78933363
153Abnormality of DNA repair (HP:0003254)1.78863767
154Cerebral aneurysm (HP:0004944)1.78384713
155Xanthomatosis (HP:0000991)1.77995804
156Achilles tendon contracture (HP:0001771)1.77686921
157Atrioventricular block (HP:0001678)1.77649276
158Easy fatigability (HP:0003388)1.76984348
159Metaphyseal cupping (HP:0003021)1.76197809
160Birth length less than 3rd percentile (HP:0003561)1.74644601
161Hemorrhage of the eye (HP:0011885)1.74466384
162Granulocytopenia (HP:0001913)1.74143130
163Chronic obstructive pulmonary disease (HP:0006510)1.73430476
164Obstructive lung disease (HP:0006536)1.73430476
165Reticulocytosis (HP:0001923)1.72931371
166Craniofacial dystonia (HP:0012179)1.72666109
167Onion bulb formation (HP:0003383)1.71180956
168Rigidity (HP:0002063)1.69821129
169Deep palmar crease (HP:0006191)1.69124966
170Hypochromic microcytic anemia (HP:0004840)1.68744671
171Attention deficit hyperactivity disorder (HP:0007018)1.67710106
172Mitral stenosis (HP:0001718)1.67400449
173Mediastinal lymphadenopathy (HP:0100721)1.67161130
174Intestinal fistula (HP:0100819)1.66703098
175Squamous cell carcinoma (HP:0002860)1.65353511
176Abnormality of the aortic arch (HP:0012303)1.65302303
177Abnormality of the radial head (HP:0003995)1.64799915
178Dislocated radial head (HP:0003083)1.64530496
179Poikiloderma (HP:0001029)1.64303695
180Microcytic anemia (HP:0001935)1.63629694
181Keratoconjunctivitis sicca (HP:0001097)1.62101101
182Emphysema (HP:0002097)1.61820203
183Hypertensive crisis (HP:0100735)1.60656859
184Hemoptysis (HP:0002105)1.60578608
185Encephalitis (HP:0002383)1.59634545
186Recurrent viral infections (HP:0004429)1.58942889
187Keratoconjunctivitis (HP:0001096)1.58638606
188Sparse lateral eyebrow (HP:0005338)1.57854683
189Spina bifida occulta (HP:0003298)1.57512521
190Narrow palate (HP:0000189)1.57494386
191Genu recurvatum (HP:0002816)1.57434681

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.64855388
2PRPF4B3.23910447
3MAP2K33.08650927
4SMG12.87916330
5KSR22.74522944
6MAP3K132.69214995
7NTRK32.46804960
8EEF2K2.44368849
9RIPK12.41854282
10IRAK42.28137618
11TRIB32.23490605
12PAK62.16874342
13DAPK22.09560861
14MAP3K41.94457735
15EPHA41.91656168
16TYRO31.87091295
17SIK21.82961576
18IRAK31.78859190
19STK381.72783172
20PRKD21.71443859
21TAOK11.70866016
22CAMKK11.66653803
23PRKCH1.66650624
24NTRK11.66531277
25KSR11.61545930
26ALK1.60350804
27MAP4K11.56886964
28FGFR41.53722741
29MAP3K111.52141801
30CAMK1G1.48720474
31MAP2K41.43492108
32MAP3K71.40446212
33MINK11.39307992
34SGK31.38185813
35GRK61.37002479
36NTRK21.35134212
37BLK1.35123294
38CAMK1D1.29659804
39MAP3K101.29108991
40MAP3K31.22088293
41IRAK21.15494787
42FES1.12072846
43TTN1.11758501
44PKN21.08151460
45SGK21.08061294
46RET1.07488233
47CDK51.05261273
48SGK2231.03069425
49SGK4941.03069425
50TAOK21.02921971
51JAK11.02770126
52CDK121.02479116
53TLK11.01942797
54ICK0.98852073
55SIK10.96146079
56RAF10.93844182
57PDK10.93146702
58MELK0.92174559
59PRKD30.90936573
60STK110.87014552
61MAP3K20.85286389
62BMX0.84864762
63RIPK40.83988442
64DAPK10.82549019
65NEK10.82245819
66ITK0.81535328
67TIE10.81176828
68IRAK10.81116554
69TNK20.80647197
70RPS6KC10.78483218
71RPS6KL10.78483218
72CDK190.77677441
73RPS6KA60.75794172
74RPS6KA20.75779949
75PAK30.75663488
76ZAP700.74921141
77FGFR20.74400822
78PTK20.73960173
79MARK20.73522406
80EPHB10.71801160
81PDGFRA0.71404223
82ERN10.71130778
83CAMK40.70750343
84CSK0.70147845
85NEK20.70075359
86SIK30.69817708
87EPHA30.69638521
88MARK30.69321759
89PDPK10.68875192
90JAK20.68801075
91PTK60.68344422
92NEK60.68259927
93HIPK20.67370411
94WNK30.67288874
95MAP3K140.67223534
96BRAF0.66045567
97RPS6KB20.65994319
98CAMK10.64385953
99FGFR30.64084908
100SGK10.63895798
101PRKCI0.63705527
102TAOK30.63662636
103MTOR0.63326724
104ERBB20.61877273
105BTK0.61734088
106TBK10.60913078
107CDK70.60808895
108PRKCG0.60722258
109SCYL20.60274178
110PDGFRB0.60070662
111AURKA0.59240985
112CHUK0.58647180
113TXK0.58394793
114TYK20.57753615
115MAPKAPK30.55115139
116UHMK10.53900895
117MAP2K70.53747548
118FYN0.53360306
119CDK40.52617397
120ARAF0.52504442
121MAPK120.51717480
122MAPK100.51654742
123AKT30.51583431
124CDK90.51269494
125TSSK60.50832919
126MARK10.50457971
127RPS6KA30.50240401
128HCK0.49911397
129IKBKB0.49732932
130IKBKE0.49131014
131LMTK20.49049615
132JAK30.48545892
133MAP3K10.46906926
134PIM10.46668958
135DYRK1B0.46335170
136BRD40.45217761
137MAP3K80.45113929
138CAMKK20.44949270
139PRKCZ0.44579028
140WNK40.44558439
141RPS6KA10.44184566
142CDC42BPA0.44019066
143CSNK1G20.43905676
144WNK10.43007031
145MAPK110.42972770
146PNCK0.42000944
147MAPK150.41129118

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.44305501
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.46363951
3Synaptic vesicle cycle_Homo sapiens_hsa047212.07137314
4Notch signaling pathway_Homo sapiens_hsa043301.99967595
5Nicotine addiction_Homo sapiens_hsa050331.87736500
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.86296718
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85567710
8Osteoclast differentiation_Homo sapiens_hsa043801.85032007
9Olfactory transduction_Homo sapiens_hsa047401.83593551
10Long-term potentiation_Homo sapiens_hsa047201.81306198
11Arginine biosynthesis_Homo sapiens_hsa002201.76359679
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.72355000
13GABAergic synapse_Homo sapiens_hsa047271.67626856
14Bile secretion_Homo sapiens_hsa049761.60102626
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55153145
16Circadian entrainment_Homo sapiens_hsa047131.53228061
17Salivary secretion_Homo sapiens_hsa049701.52975010
18Morphine addiction_Homo sapiens_hsa050321.51941078
19Glutamatergic synapse_Homo sapiens_hsa047241.50240786
20Gastric acid secretion_Homo sapiens_hsa049711.46961553
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45346706
22Sulfur relay system_Homo sapiens_hsa041221.44005948
23Pancreatic cancer_Homo sapiens_hsa052121.42289965
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42273463
25Ovarian steroidogenesis_Homo sapiens_hsa049131.36143325
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.34635177
27Amphetamine addiction_Homo sapiens_hsa050311.34083597
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32020053
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31073653
30FoxO signaling pathway_Homo sapiens_hsa040681.29809903
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26756589
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25380403
33Dorso-ventral axis formation_Homo sapiens_hsa043201.24862756
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22661103
35Type II diabetes mellitus_Homo sapiens_hsa049301.22609979
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22257789
37Dopaminergic synapse_Homo sapiens_hsa047281.22040315
38Cholinergic synapse_Homo sapiens_hsa047251.20672611
39T cell receptor signaling pathway_Homo sapiens_hsa046601.20631756
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19919208
41Insulin secretion_Homo sapiens_hsa049111.17756080
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16199912
43Hepatitis B_Homo sapiens_hsa051611.15283746
44Thyroid cancer_Homo sapiens_hsa052161.13960181
45Estrogen signaling pathway_Homo sapiens_hsa049151.13938818
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13137721
47mTOR signaling pathway_Homo sapiens_hsa041501.12702833
48Glioma_Homo sapiens_hsa052141.11528678
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.11308821
50Non-small cell lung cancer_Homo sapiens_hsa052231.10240552
51Oxytocin signaling pathway_Homo sapiens_hsa049211.10008731
52Prostate cancer_Homo sapiens_hsa052151.09349372
53GnRH signaling pathway_Homo sapiens_hsa049121.08645689
54Butanoate metabolism_Homo sapiens_hsa006501.04940460
55TNF signaling pathway_Homo sapiens_hsa046681.04224208
56Hepatitis C_Homo sapiens_hsa051601.03153286
57Vitamin B6 metabolism_Homo sapiens_hsa007501.02671994
58Phospholipase D signaling pathway_Homo sapiens_hsa040721.01933804
59Measles_Homo sapiens_hsa051621.01616630
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01275669
61Viral carcinogenesis_Homo sapiens_hsa052030.98043149
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97242310
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.95292597
64Renin secretion_Homo sapiens_hsa049240.95102015
65mRNA surveillance pathway_Homo sapiens_hsa030150.94323027
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94306188
67Influenza A_Homo sapiens_hsa051640.94123655
68Choline metabolism in cancer_Homo sapiens_hsa052310.94068653
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93969920
70Apoptosis_Homo sapiens_hsa042100.92762603
71HTLV-I infection_Homo sapiens_hsa051660.91683267
72Cocaine addiction_Homo sapiens_hsa050300.91439595
73Colorectal cancer_Homo sapiens_hsa052100.91324664
74Herpes simplex infection_Homo sapiens_hsa051680.90673323
75ErbB signaling pathway_Homo sapiens_hsa040120.90326295
76Leishmaniasis_Homo sapiens_hsa051400.89971094
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89461759
78Other glycan degradation_Homo sapiens_hsa005110.89008847
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88161788
80Bladder cancer_Homo sapiens_hsa052190.87174306
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87027519
82cAMP signaling pathway_Homo sapiens_hsa040240.85889390
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85699166
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85617023
85Primary immunodeficiency_Homo sapiens_hsa053400.84221698
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.84203954
87Gap junction_Homo sapiens_hsa045400.83552076
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83445983
89Tuberculosis_Homo sapiens_hsa051520.81121136
90Calcium signaling pathway_Homo sapiens_hsa040200.81105630
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81090049
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.80808077
93Lysine degradation_Homo sapiens_hsa003100.80787445
94MicroRNAs in cancer_Homo sapiens_hsa052060.80648910
95VEGF signaling pathway_Homo sapiens_hsa043700.79469569
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.78000609
97Cell cycle_Homo sapiens_hsa041100.77960494
98Long-term depression_Homo sapiens_hsa047300.77338470
99Endometrial cancer_Homo sapiens_hsa052130.76713568
100Inositol phosphate metabolism_Homo sapiens_hsa005620.76456317
101Toxoplasmosis_Homo sapiens_hsa051450.75856654
102Small cell lung cancer_Homo sapiens_hsa052220.73607651
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72895016
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72598496
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72571302
106B cell receptor signaling pathway_Homo sapiens_hsa046620.72272929
107Taste transduction_Homo sapiens_hsa047420.71436625
108Glucagon signaling pathway_Homo sapiens_hsa049220.71089887
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.70683668
110Renal cell carcinoma_Homo sapiens_hsa052110.70627578
111Fructose and mannose metabolism_Homo sapiens_hsa000510.70466372
112Insulin signaling pathway_Homo sapiens_hsa049100.70077331
113HIF-1 signaling pathway_Homo sapiens_hsa040660.69795614
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69305930
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.66954962
116Tryptophan metabolism_Homo sapiens_hsa003800.64679662
117Melanoma_Homo sapiens_hsa052180.63807620
118Insulin resistance_Homo sapiens_hsa049310.63770998
119Epstein-Barr virus infection_Homo sapiens_hsa051690.61661903
120Thyroid hormone synthesis_Homo sapiens_hsa049180.60928343
121MAPK signaling pathway_Homo sapiens_hsa040100.60507199
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60351701
123Chronic myeloid leukemia_Homo sapiens_hsa052200.60124950
124Ras signaling pathway_Homo sapiens_hsa040140.59924297
125Fanconi anemia pathway_Homo sapiens_hsa034600.59587807
126Glycerolipid metabolism_Homo sapiens_hsa005610.59286393
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58563019
128Prolactin signaling pathway_Homo sapiens_hsa049170.56646112
129Endocytosis_Homo sapiens_hsa041440.56352684
130Acute myeloid leukemia_Homo sapiens_hsa052210.55745045
131Platelet activation_Homo sapiens_hsa046110.55549063
132Rap1 signaling pathway_Homo sapiens_hsa040150.54952141
133Prion diseases_Homo sapiens_hsa050200.54826896
134Melanogenesis_Homo sapiens_hsa049160.54597500
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54236459
136Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54038972
137ABC transporters_Homo sapiens_hsa020100.53389731
138Biosynthesis of amino acids_Homo sapiens_hsa012300.52499713
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52020904
140Pathways in cancer_Homo sapiens_hsa052000.51879183
141Base excision repair_Homo sapiens_hsa034100.51510057
142Chemokine signaling pathway_Homo sapiens_hsa040620.51296631
143Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50006806
144Oocyte meiosis_Homo sapiens_hsa041140.49531290
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.49104654
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.49076066
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48850052
148Axon guidance_Homo sapiens_hsa043600.48676318
149AMPK signaling pathway_Homo sapiens_hsa041520.48527309
150Glycosaminoglycan degradation_Homo sapiens_hsa005310.48060709
151PPAR signaling pathway_Homo sapiens_hsa033200.46798909
152Basal transcription factors_Homo sapiens_hsa030220.46713943

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