UPB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)8.01380695
2epoxygenase P450 pathway (GO:0019373)7.83945904
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.60473800
4L-phenylalanine catabolic process (GO:0006559)7.60473800
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.23917230
6L-phenylalanine metabolic process (GO:0006558)7.23917230
7aromatic amino acid family catabolic process (GO:0009074)7.03522932
8indole-containing compound catabolic process (GO:0042436)6.51701089
9indolalkylamine catabolic process (GO:0046218)6.51701089
10tryptophan catabolic process (GO:0006569)6.51701089
11kynurenine metabolic process (GO:0070189)6.19941506
12tryptophan metabolic process (GO:0006568)6.15441654
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.05700878
14oxidative demethylation (GO:0070989)6.03818145
15bile acid biosynthetic process (GO:0006699)5.89901255
16glyoxylate metabolic process (GO:0046487)5.81507032
17drug metabolic process (GO:0017144)5.69980029
18urea cycle (GO:0000050)5.56314655
19urea metabolic process (GO:0019627)5.56314655
20cysteine metabolic process (GO:0006534)5.42706864
21high-density lipoprotein particle remodeling (GO:0034375)5.40105053
22alpha-linolenic acid metabolic process (GO:0036109)5.33094763
23negative regulation of fibrinolysis (GO:0051918)5.32404347
24sulfur amino acid catabolic process (GO:0000098)5.26819471
25protein carboxylation (GO:0018214)5.21609859
26peptidyl-glutamic acid carboxylation (GO:0017187)5.21609859
27regulation of fibrinolysis (GO:0051917)5.20961579
28serine family amino acid catabolic process (GO:0009071)5.15795317
29complement activation, alternative pathway (GO:0006957)5.14170046
30aromatic amino acid family metabolic process (GO:0009072)5.12691158
31nitrogen cycle metabolic process (GO:0071941)5.11918869
32regulation of protein activation cascade (GO:2000257)5.10899164
33bile acid metabolic process (GO:0008206)5.08425502
34phenylpropanoid metabolic process (GO:0009698)4.96343122
35homocysteine metabolic process (GO:0050667)4.96287727
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.92776007
37tyrosine metabolic process (GO:0006570)4.88389448
38S-adenosylmethionine metabolic process (GO:0046500)4.86770792
39regulation of complement activation (GO:0030449)4.76048304
40regulation of cholesterol esterification (GO:0010872)4.71206986
41alpha-amino acid catabolic process (GO:1901606)4.70331050
42reverse cholesterol transport (GO:0043691)4.69811301
43amino-acid betaine metabolic process (GO:0006577)4.69176495
44indolalkylamine metabolic process (GO:0006586)4.69001967
45lysine catabolic process (GO:0006554)4.67520461
46lysine metabolic process (GO:0006553)4.67520461
47plasma lipoprotein particle remodeling (GO:0034369)4.61731843
48protein-lipid complex remodeling (GO:0034368)4.61731843
49macromolecular complex remodeling (GO:0034367)4.61731843
50regulation of triglyceride catabolic process (GO:0010896)4.58987285
51cellular biogenic amine catabolic process (GO:0042402)4.58482475
52amine catabolic process (GO:0009310)4.58482475
53ethanol metabolic process (GO:0006067)4.56332027
54acylglycerol homeostasis (GO:0055090)4.54954477
55triglyceride homeostasis (GO:0070328)4.54954477
56phospholipid efflux (GO:0033700)4.44130354
57bile acid and bile salt transport (GO:0015721)4.41603992
58negative regulation of sterol transport (GO:0032372)4.41102335
59negative regulation of cholesterol transport (GO:0032375)4.41102335
60cellular glucuronidation (GO:0052695)4.40206555
61cellular ketone body metabolic process (GO:0046950)4.39163137
62coenzyme catabolic process (GO:0009109)4.39136003
63alkaloid metabolic process (GO:0009820)4.37660033
64cellular amino acid catabolic process (GO:0009063)4.32271756
65imidazole-containing compound metabolic process (GO:0052803)4.31860047
66glycine metabolic process (GO:0006544)4.25123337
67benzene-containing compound metabolic process (GO:0042537)4.23885969
68glutamate metabolic process (GO:0006536)4.20976924
69drug catabolic process (GO:0042737)4.19868271
70serine family amino acid metabolic process (GO:0009069)4.17060327
71plasma lipoprotein particle clearance (GO:0034381)4.15112199
72cellular modified amino acid catabolic process (GO:0042219)4.12045983
73cholesterol efflux (GO:0033344)4.10163796
74dicarboxylic acid biosynthetic process (GO:0043650)4.02504787
75aldehyde catabolic process (GO:0046185)4.00004106
76ethanol oxidation (GO:0006069)3.99747887
77low-density lipoprotein particle remodeling (GO:0034374)3.96139817
78glucuronate metabolic process (GO:0019585)3.95166436
79uronic acid metabolic process (GO:0006063)3.95166436
80arginine metabolic process (GO:0006525)3.94842685
81serine family amino acid biosynthetic process (GO:0009070)3.93004154
82regulation of plasminogen activation (GO:0010755)3.91355155
83fibrinolysis (GO:0042730)3.86531434
84plasma lipoprotein particle assembly (GO:0034377)3.83718027
85short-chain fatty acid metabolic process (GO:0046459)3.81426924
86regulation of bile acid biosynthetic process (GO:0070857)3.81279199
87organic acid catabolic process (GO:0016054)3.79768852
88carboxylic acid catabolic process (GO:0046395)3.79768852
89ketone body metabolic process (GO:1902224)3.79416603
90blood coagulation, intrinsic pathway (GO:0007597)3.77598023
91negative regulation of blood coagulation (GO:0030195)3.77403220
92negative regulation of hemostasis (GO:1900047)3.77403220
93NAD biosynthetic process (GO:0009435)3.76682928
94cofactor catabolic process (GO:0051187)3.73016417
95drug transmembrane transport (GO:0006855)3.73002132
96negative regulation of lipase activity (GO:0060192)3.71907349
97urate metabolic process (GO:0046415)3.68522431
98phospholipid homeostasis (GO:0055091)3.67890547
99very-low-density lipoprotein particle assembly (GO:0034379)3.67691510
100exogenous drug catabolic process (GO:0042738)3.66838397
101acetyl-CoA metabolic process (GO:0006084)3.66568512
102positive regulation of lipoprotein lipase activity (GO:0051006)3.65517004
103positive regulation of triglyceride lipase activity (GO:0061365)3.65517004
104opsonization (GO:0008228)3.64881578
105nicotinamide nucleotide biosynthetic process (GO:0019359)3.64425040
106pyridine nucleotide biosynthetic process (GO:0019363)3.64425040
107arginine catabolic process (GO:0006527)3.64165509
108cholesterol homeostasis (GO:0042632)3.63948273
109regulation of humoral immune response (GO:0002920)3.62262623
110cytolysis (GO:0019835)3.61709914
111complement activation, classical pathway (GO:0006958)3.61480799
112protein activation cascade (GO:0072376)3.61086749
113complement activation (GO:0006956)3.58597518
114sterol homeostasis (GO:0055092)3.58321237
115flavonoid metabolic process (GO:0009812)3.56185437
116heme transport (GO:0015886)3.50133453
117negative regulation of protein activation cascade (GO:2000258)3.45106145
118killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.44315598
119disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.44315598
120acute-phase response (GO:0006953)3.42648009
121negative regulation of coagulation (GO:0050819)3.42090987
122sodium-independent organic anion transport (GO:0043252)3.37451139
123negative regulation of wound healing (GO:0061045)3.33442404
124intestinal cholesterol absorption (GO:0030299)3.30778071
125xenobiotic metabolic process (GO:0006805)3.27965186
126positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.27142978
127L-methionine salvage (GO:0071267)3.25523589
128L-methionine biosynthetic process (GO:0071265)3.25523589
129amino acid salvage (GO:0043102)3.25523589
130fat-soluble vitamin biosynthetic process (GO:0042362)3.22800504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.18271191
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.10729733
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.95422021
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.38589713
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.21831223
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.99786316
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.26934617
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.05803557
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.97635481
10ZNF274_21170338_ChIP-Seq_K562_Hela2.85948260
11GBX2_23144817_ChIP-Seq_PC3_Human2.35508359
12VDR_22108803_ChIP-Seq_LS180_Human2.12989156
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10581592
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02667800
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5174778
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98090568
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91857873
18IGF1R_20145208_ChIP-Seq_DFB_Human1.90865006
19ER_23166858_ChIP-Seq_MCF-7_Human1.88204405
20* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.87432319
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70888125
22HTT_18923047_ChIP-ChIP_STHdh_Human1.64922536
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64387979
24EZH2_22144423_ChIP-Seq_EOC_Human1.62864308
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62002645
26GATA1_22025678_ChIP-Seq_K562_Human1.61996490
27* FOXA2_19822575_ChIP-Seq_HepG2_Human1.58713013
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.52526376
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49915116
30CBP_20019798_ChIP-Seq_JUKART_Human1.49915116
31P300_19829295_ChIP-Seq_ESCs_Human1.49229596
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45894530
33GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.44757367
34* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40754746
35* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36735687
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35144033
37NANOG_19829295_ChIP-Seq_ESCs_Human1.33937075
38SOX2_19829295_ChIP-Seq_ESCs_Human1.33937075
39FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30846505
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.30846505
41* STAT3_23295773_ChIP-Seq_U87_Human1.28639813
42TCF4_22108803_ChIP-Seq_LS180_Human1.27565003
43AR_25329375_ChIP-Seq_VCAP_Human1.26369342
44* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25946779
45TCF4_23295773_ChIP-Seq_U87_Human1.25581332
46ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25020606
47FUS_26573619_Chip-Seq_HEK293_Human1.24290406
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22288816
49FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21721636
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21715919
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21508039
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.20443105
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19690560
54CLOCK_20551151_ChIP-Seq_293T_Human1.16511074
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16274022
56RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15861098
57SMAD4_21741376_ChIP-Seq_EPCs_Human1.14497967
58TP53_22573176_ChIP-Seq_HFKS_Human1.13893035
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12159141
60RUNX2_22187159_ChIP-Seq_PCA_Human1.11689126
61SMAD4_21799915_ChIP-Seq_A2780_Human1.11322120
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10713699
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10713699
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.10147386
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08756243
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05954523
67MYC_19829295_ChIP-Seq_ESCs_Human1.05949288
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05843043
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04215016
70EWS_26573619_Chip-Seq_HEK293_Human1.03604526
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02753107
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02276766
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01375847
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00924235
75PHF8_20622853_ChIP-Seq_HELA_Human1.00808565
76* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99963905
77SMAD3_21741376_ChIP-Seq_EPCs_Human0.98648978
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98312243
79REST_21632747_ChIP-Seq_MESCs_Mouse0.98262337
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94863513
81KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94375043
82NANOG_18555785_Chip-Seq_ESCs_Mouse0.94279612
83ETV1_20927104_ChIP-Seq_GIST48_Human0.93571489
84GATA3_26560356_Chip-Seq_TH2_Human0.93005531
85NFYA_21822215_ChIP-Seq_K562_Human0.92796020
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92702488
87CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92116182
88SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88726160
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88352295
90GATA4_25053715_ChIP-Seq_YYC3_Human0.85978790
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85631190
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84983513
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81442845
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80094157
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78943092
96AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73975680
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73726180
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72786311
99NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72786311
100TAF15_26573619_Chip-Seq_HEK293_Human0.71086283
101RARA_24833708_ChIP-Seq_LIVER_Mouse0.67105226
102ESR1_15608294_ChIP-ChIP_MCF-7_Human0.66985415
103AR_20517297_ChIP-Seq_VCAP_Human0.65602903
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64786753
105STAT1_17558387_ChIP-Seq_HELA_Human0.64473571
106* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.64222498
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.63307054
108SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62665523
109RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62371893
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62364280
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.60995390
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.60440817
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.59883338
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.59621978
115EZH2_27294783_Chip-Seq_NPCs_Mouse0.58327859
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.58079359
117RARG_19884340_ChIP-ChIP_MEFs_Mouse0.58038131
118* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.57932805
119* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57770485
120ESR2_21235772_ChIP-Seq_MCF-7_Human0.57399669
121CBP_21632823_ChIP-Seq_H3396_Human0.56868188
122FOXA1_25552417_ChIP-Seq_VCAP_Human0.56386801
123RARB_24833708_ChIP-Seq_LIVER_Mouse0.56207455
124FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.56155424
125CEBPB_22108803_ChIP-Seq_LS180_Human0.55953957
126ESET_19884257_ChIP-Seq_ESCs_Mouse0.55088810
127ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.54721696
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.54446159
129SUZ12_27294783_Chip-Seq_NPCs_Mouse0.53592665
130MYC_19915707_ChIP-ChIP_AK7_Human0.53538254
131* CRX_20693478_ChIP-Seq_RETINA_Mouse0.52140581
132* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.51084636
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.50872286
134FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.50728389
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.50365586
136BCAT_22108803_ChIP-Seq_LS180_Human0.50336289
137CDX2_20551321_ChIP-Seq_CACO-2_Human0.50257863
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.50144222
139PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49756656
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.49318841
141EGR1_19032775_ChIP-ChIP_M12_Human0.48165015
142IRF1_19129219_ChIP-ChIP_H3396_Human0.47885999
143RUNX1_27457419_Chip-Seq_LIVER_Mouse0.47659676
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.47332667
145CDX2_22108803_ChIP-Seq_LS180_Human0.46701460
146P53_21459846_ChIP-Seq_SAOS-2_Human0.43747842
147* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.43455976
148NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.42883534
149TAF2_19829295_ChIP-Seq_ESCs_Human0.40936554
150NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.39387254
151ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.39258649
152ESR1_20079471_ChIP-ChIP_T-47D_Human0.39035935
153SMAD1_18555785_Chip-Seq_ESCs_Mouse0.38642458
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.38581518
155GATA1_19941827_ChIP-Seq_MEL_Mouse0.38310966
156FOXH1_21741376_ChIP-Seq_EPCs_Human0.37927206
157NCOR_22424771_ChIP-Seq_293T_Human0.37919542
158ESRRB_18555785_Chip-Seq_ESCs_Mouse0.37748971
159GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.37545121
160SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.36354309

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.27574082
2MP0005360_urolithiasis7.64383211
3MP0005085_abnormal_gallbladder_physiolo6.42056692
4MP0005365_abnormal_bile_salt6.15395799
5MP0008875_abnormal_xenobiotic_pharmacok5.15240717
6MP0003806_abnormal_nucleotide_metabolis4.08796700
7MP0003252_abnormal_bile_duct3.98538247
8MP0010329_abnormal_lipoprotein_level3.46217962
9MP0003195_calcinosis3.15716649
10MP0009840_abnormal_foam_cell2.95154885
11MP0005083_abnormal_biliary_tract2.92408330
12MP0005332_abnormal_amino_acid2.87780217
13MP0001666_abnormal_nutrient_absorption2.55738573
14MP0004019_abnormal_vitamin_homeostasis2.37867955
15MP0002138_abnormal_hepatobiliary_system2.19800797
16MP0003191_abnormal_cellular_cholesterol2.14795931
17MP0000609_abnormal_liver_physiology2.08342000
18MP0002118_abnormal_lipid_homeostasis2.06034176
19MP0003868_abnormal_feces_composition1.91425885
20MP0001764_abnormal_homeostasis1.78308833
21MP0005319_abnormal_enzyme/_coenzyme1.78284375
22MP0009697_abnormal_copulation1.77860930
23MP0005451_abnormal_body_composition1.59111429
24MP0005584_abnormal_enzyme/coenzyme_acti1.53855230
25MP0008877_abnormal_DNA_methylation1.39176195
26MP0009643_abnormal_urine_homeostasis1.38672130
27MP0003646_muscle_fatigue1.36781269
28MP0003011_delayed_dark_adaptation1.35520324
29MP0005551_abnormal_eye_electrophysiolog1.31221946
30MP0003186_abnormal_redox_activity1.28540115
31MP0005647_abnormal_sex_gland1.20901105
32MP0009764_decreased_sensitivity_to1.16201825
33MP0005167_abnormal_blood-brain_barrier1.13736056
34MP0004142_abnormal_muscle_tone1.13102404
35MP0001986_abnormal_taste_sensitivity1.12684951
36MP0000598_abnormal_liver_morphology1.11904032
37MP0005636_abnormal_mineral_homeostasis1.07179105
38MP0003656_abnormal_erythrocyte_physiolo1.05958129
39MP0002876_abnormal_thyroid_physiology1.05847530
40MP0005646_abnormal_pituitary_gland1.01020424
41MP0009763_increased_sensitivity_to0.97813918
42MP0005379_endocrine/exocrine_gland_phen0.95847880
43MP0001501_abnormal_sleep_pattern0.95678923
44MP0009745_abnormal_behavioral_response0.95416920
45MP0002254_reproductive_system_inflammat0.95320324
46MP0005408_hypopigmentation0.92833128
47MP0005084_abnormal_gallbladder_morpholo0.91004398
48MP0008469_abnormal_protein_level0.89757191
49MP0009642_abnormal_blood_homeostasis0.89589826
50MP0000604_amyloidosis0.88884589
51MP0006292_abnormal_olfactory_placode0.88172833
52MP0005645_abnormal_hypothalamus_physiol0.87775543
53MP0009785_altered_susceptibility_to0.87475238
54MP0005220_abnormal_exocrine_pancreas0.86655139
55MP0005670_abnormal_white_adipose0.85297523
56MP0010368_abnormal_lymphatic_system0.84878930
57MP0002078_abnormal_glucose_homeostasis0.82472027
58MP0002282_abnormal_trachea_morphology0.80334495
59MP0009765_abnormal_xenobiotic_induced0.78676213
60MP0006036_abnormal_mitochondrial_physio0.78483042
61MP0005376_homeostasis/metabolism_phenot0.77659328
62MP0005535_abnormal_body_temperature0.77152394
63MP0003705_abnormal_hypodermis_morpholog0.76000523
64MP0001756_abnormal_urination0.73196518
65MP0005334_abnormal_fat_pad0.71153841
66MP0001968_abnormal_touch/_nociception0.70376692
67MP0009046_muscle_twitch0.70245817
68MP0001661_extended_life_span0.69709440
69MP0006072_abnormal_retinal_apoptosis0.68361529
70MP0003879_abnormal_hair_cell0.67053363
71MP0001984_abnormal_olfaction0.67045002
72MP0002971_abnormal_brown_adipose0.65908480
73MP0002638_abnormal_pupillary_reflex0.64414860
74MP0000569_abnormal_digit_pigmentation0.64311765
75MP0002102_abnormal_ear_morphology0.64061061
76MP0004133_heterotaxia0.63007262
77MP0005253_abnormal_eye_physiology0.62815522
78MP0005386_behavior/neurological_phenoty0.62734101
79MP0004924_abnormal_behavior0.62734101
80MP0002928_abnormal_bile_duct0.62521500
81MP0002909_abnormal_adrenal_gland0.61418231
82MP0005377_hearing/vestibular/ear_phenot0.61159308
83MP0003878_abnormal_ear_physiology0.61159308
84MP0001485_abnormal_pinna_reflex0.60722722
85MP0005266_abnormal_metabolism0.58788717
86MP0002272_abnormal_nervous_system0.58717028
87MP0004782_abnormal_surfactant_physiolog0.58622118
88MP0003690_abnormal_glial_cell0.58615242
89MP0000639_abnormal_adrenal_gland0.58536742
90MP0005410_abnormal_fertilization0.58268685
91MP0002064_seizures0.58256426
92MP0005187_abnormal_penis_morphology0.57040540
93MP0002136_abnormal_kidney_physiology0.56567262
94MP0004043_abnormal_pH_regulation0.54371778
95MP0009053_abnormal_anal_canal0.53391045
96MP0005448_abnormal_energy_balance0.53012804
97MP0005395_other_phenotype0.52604349
98MP0004130_abnormal_muscle_cell0.52035872
99MP0004381_abnormal_hair_follicle0.51273990
100MP0003724_increased_susceptibility_to0.50381203
101MP0001486_abnormal_startle_reflex0.48801729
102MP0005464_abnormal_platelet_physiology0.48788333
103MP0004147_increased_porphyrin_level0.48504926
104MP0010386_abnormal_urinary_bladder0.48277276
105MP0002653_abnormal_ependyma_morphology0.48037761
106MP0006035_abnormal_mitochondrial_morpho0.47675773
107MP0003633_abnormal_nervous_system0.47567068
108MP0003953_abnormal_hormone_level0.47220999
109MP0003718_maternal_effect0.46946882
110MP0000427_abnormal_hair_cycle0.46479772
111MP0004742_abnormal_vestibular_system0.45923186
112MP0005248_abnormal_Harderian_gland0.44305485
113MP0003638_abnormal_response/metabolism_0.43925694
114MP0000579_abnormal_nail_morphology0.43830622
115MP0008874_decreased_physiological_sensi0.41851614
116MP0003329_amyloid_beta_deposits0.41760410
117MP0002822_catalepsy0.40275507
118MP0003436_decreased_susceptibility_to0.39851571
119MP0000230_abnormal_systemic_arterial0.39542645
120MP0002168_other_aberrant_phenotype0.38593665
121MP0008873_increased_physiological_sensi0.36448273
122MP0002132_abnormal_respiratory_system0.35731297
123MP0001765_abnormal_ion_homeostasis0.35693252
124MP0009672_abnormal_birth_weight0.35255143
125MP0008872_abnormal_physiological_respon0.35212446
126MP0001944_abnormal_pancreas_morphology0.31918436
127MP0005166_decreased_susceptibility_to0.31492275
128MP0001845_abnormal_inflammatory_respons0.30646307
129MP0002837_dystrophic_cardiac_calcinosis0.30393965
130MP0009384_cardiac_valve_regurgitation0.29536490
131MP0009115_abnormal_fat_cell0.29493103
132MP0003075_altered_response_to0.29368536
133MP0001853_heart_inflammation0.29250503
134MP0000538_abnormal_urinary_bladder0.29006657
135MP0005666_abnormal_adipose_tissue0.28457126
136MP0000249_abnormal_blood_vessel0.28131528
137MP0006082_CNS_inflammation0.27086219
138MP0005058_abnormal_lysosome_morphology0.25430377
139MP0004264_abnormal_extraembryonic_tissu0.25186669
140MP0004883_abnormal_blood_vessel0.25119408
141MP0001881_abnormal_mammary_gland0.24684132

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.42705470
2Intrahepatic cholestasis (HP:0001406)7.27692575
3Deep venous thrombosis (HP:0002625)7.02841325
4Prolonged partial thromboplastin time (HP:0003645)6.58958541
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.55618947
6Hypobetalipoproteinemia (HP:0003563)6.13947823
7Xanthomatosis (HP:0000991)6.06674451
8Hyperlipoproteinemia (HP:0010980)5.32211748
9Complement deficiency (HP:0004431)5.11303974
10Joint hemorrhage (HP:0005261)4.95802493
11Hypolipoproteinemia (HP:0010981)4.55828524
12Hyperammonemia (HP:0001987)4.52154807
13Epidermoid cyst (HP:0200040)4.50762756
14Hyperglycinemia (HP:0002154)4.49951877
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.40522839
16Ketosis (HP:0001946)4.36351585
17Abnormality of the common coagulation pathway (HP:0010990)4.35955205
18Abnormality of methionine metabolism (HP:0010901)4.30845262
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.30844477
20Abnormality of aspartate family amino acid metabolism (HP:0010899)4.28309138
21Hyperglycinuria (HP:0003108)4.19400319
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.17508186
23Fat malabsorption (HP:0002630)4.15415225
24Conjugated hyperbilirubinemia (HP:0002908)4.09415750
25Abnormality of glycine metabolism (HP:0010895)4.05790692
26Abnormality of serine family amino acid metabolism (HP:0010894)4.05790692
27Abnormality of pyrimidine metabolism (HP:0004353)4.01841247
28Hypoglycemic coma (HP:0001325)4.01450169
29Hypoalphalipoproteinemia (HP:0003233)3.96531248
30Abnormality of the intrinsic pathway (HP:0010989)3.77378519
31Abnormality of complement system (HP:0005339)3.68966716
32Fair hair (HP:0002286)3.57039732
33Hypercholesterolemia (HP:0003124)3.51395078
34Abnormality of fatty-acid metabolism (HP:0004359)3.40622739
35Hyperbilirubinemia (HP:0002904)3.36474645
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32253905
37Abnormality of nucleobase metabolism (HP:0010932)3.29274266
38Ketoacidosis (HP:0001993)3.26708713
39Abnormality of serum amino acid levels (HP:0003112)3.14249772
40Steatorrhea (HP:0002570)3.11518344
41Hepatocellular carcinoma (HP:0001402)2.96522954
42Hypochromic microcytic anemia (HP:0004840)2.94868472
43Abnormality of purine metabolism (HP:0004352)2.92990776
44Metabolic acidosis (HP:0001942)2.90448733
45Myocardial infarction (HP:0001658)2.87627492
46Spontaneous abortion (HP:0005268)2.85937055
47Hypoglycemic seizures (HP:0002173)2.84703046
48Nephritis (HP:0000123)2.81219176
49Vascular calcification (HP:0004934)2.77472810
50Gout (HP:0001997)2.72292223
51Systemic lupus erythematosus (HP:0002725)2.72284828
52Bile duct proliferation (HP:0001408)2.69312733
53Abnormal biliary tract physiology (HP:0012439)2.69312733
54Generalized hypopigmentation of hair (HP:0011358)2.66977018
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66802847
56Dicarboxylic aciduria (HP:0003215)2.66802847
57Skin nodule (HP:0200036)2.65164099
58Lethargy (HP:0001254)2.64722115
59Pancreatic cysts (HP:0001737)2.52183245
60Enlarged kidneys (HP:0000105)2.50645697
61Glomerulonephritis (HP:0000099)2.43777126
62Cardiovascular calcification (HP:0011915)2.42932938
63Acanthocytosis (HP:0001927)2.42242631
64Cerebral edema (HP:0002181)2.42055718
65Generalized aminoaciduria (HP:0002909)2.41765734
66Renal cortical cysts (HP:0000803)2.40066218
67Mitral stenosis (HP:0001718)2.38976218
68Irritability (HP:0000737)2.37446323
69Congenital stationary night blindness (HP:0007642)2.36231195
70Abnormality of the renal cortex (HP:0011035)2.32284549
71Recurrent gram-negative bacterial infections (HP:0005420)2.31561448
72Hyperventilation (HP:0002883)2.31483788
73Abnormal gallbladder morphology (HP:0012437)2.29902206
74Hyperinsulinemic hypoglycemia (HP:0000825)2.27532334
75Arthropathy (HP:0003040)2.25594342
76Neonatal onset (HP:0003623)2.24902250
77Spastic diplegia (HP:0001264)2.24487515
78Malnutrition (HP:0004395)2.23995971
79Pancreatitis (HP:0001733)2.23522205
80* Delayed CNS myelination (HP:0002188)2.22220620
81Alkalosis (HP:0001948)2.22181218
82Abnormality of vitamin metabolism (HP:0100508)2.20704456
83Late onset (HP:0003584)2.20395937
84Menorrhagia (HP:0000132)2.19481906
85Gingival bleeding (HP:0000225)2.19247005
86Cholelithiasis (HP:0001081)2.17915681
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16925938
88Abnormality of alanine metabolism (HP:0010916)2.16925938
89Hyperalaninemia (HP:0003348)2.16925938
90Chronic hepatic failure (HP:0100626)2.16191758
91Sensorimotor neuropathy (HP:0007141)2.15367774
92Brushfield spots (HP:0001088)2.15240337
93Rickets (HP:0002748)2.15146701
94Vomiting (HP:0002013)2.12378674
95Pancreatic fibrosis (HP:0100732)2.12220648
96Opisthotonus (HP:0002179)2.11166771
97Osteomalacia (HP:0002749)2.09904635
98Amyloidosis (HP:0011034)2.09312437
99Esophageal varix (HP:0002040)2.09037566
100Hydroxyprolinuria (HP:0003080)2.08750017
101Abnormality of proline metabolism (HP:0010907)2.08750017
102Type II lissencephaly (HP:0007260)2.08661551
103Proximal tubulopathy (HP:0000114)2.08281899
104Hypophosphatemic rickets (HP:0004912)2.08268863
105Hypothermia (HP:0002045)2.07252307
106True hermaphroditism (HP:0010459)2.05845487
107Abnormality of midbrain morphology (HP:0002418)2.05012265
108Molar tooth sign on MRI (HP:0002419)2.05012265
109Symptomatic seizures (HP:0011145)2.03524988
110Thrombophlebitis (HP:0004418)2.01172860
111Abnormal enzyme/coenzyme activity (HP:0012379)1.99486319
112Cholecystitis (HP:0001082)1.98927939
113Abnormal gallbladder physiology (HP:0012438)1.98927939
114Glycosuria (HP:0003076)1.96089620
115Abnormality of urine glucose concentration (HP:0011016)1.96089620
116Increased purine levels (HP:0004368)1.93337684
117Hyperuricemia (HP:0002149)1.93337684
118Poikilocytosis (HP:0004447)1.93193640
119Hemorrhage of the eye (HP:0011885)1.88751834
120Elevated hepatic transaminases (HP:0002910)1.88704206
121Abnormality of the gallbladder (HP:0005264)1.88068577
122Abnormality of transition element cation homeostasis (HP:0011030)1.86836419
123Azoospermia (HP:0000027)1.85532970
124Pulmonary embolism (HP:0002204)1.85452849
125Hyperglycemia (HP:0003074)1.83518384
126Nephronophthisis (HP:0000090)1.83387240
127Hyperphosphaturia (HP:0003109)1.80248345
128Neonatal hypoglycemia (HP:0001998)1.78411667
129Methylmalonic acidemia (HP:0002912)1.77099953
130Abolished electroretinogram (ERG) (HP:0000550)1.75938250
131Decreased central vision (HP:0007663)1.75754619
1323-Methylglutaconic aciduria (HP:0003535)1.74631262
133Hypochromic anemia (HP:0001931)1.73701764
134Attenuation of retinal blood vessels (HP:0007843)1.72699065
135Gangrene (HP:0100758)1.72323664
136Blue irides (HP:0000635)1.72060731
137Tubular atrophy (HP:0000092)1.70576293
138Retrobulbar optic neuritis (HP:0100654)1.70308848
139Optic neuritis (HP:0100653)1.70308848
140Abnormal drinking behavior (HP:0030082)1.64403349
141Polydipsia (HP:0001959)1.64403349

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.67224637
2FGFR44.32799967
3INSRR4.17952295
4SIK14.03768120
5TAOK33.63773815
6ERN13.60577070
7MAP4K22.79873288
8ERBB42.76331471
9ZAK2.50692763
10BMPR1B2.30922576
11TLK12.25451094
12MST1R2.10803052
13PIK3CG2.09237990
14ACVR1B2.08888652
15MAP2K41.98973133
16FLT31.95063714
17MAPK131.94365328
18LATS11.90955626
19MAPK111.79565317
20FRK1.78347312
21MAP3K41.72205106
22MAP3K141.70376726
23TYK21.70327753
24IRAK31.60519502
25STK38L1.59644538
26PINK11.56658184
27TXK1.52475824
28STK391.49185726
29CASK1.46742784
30NTRK31.32332667
31MAPK151.28396360
32NEK91.27135316
33PRKAA21.23188056
34ABL21.22795417
35TNK21.21954978
36CAMKK21.21737476
37DAPK21.17205458
38PTK61.14634884
39FGFR21.12985897
40JAK21.11536814
41PKN21.10960018
42JAK11.09121893
43MAP3K71.08195081
44MAPKAPK31.06280798
45ITK1.02475818
46EPHA30.99843538
47TIE10.96694738
48TBK10.96561830
49PTK2B0.96448450
50PAK30.96331183
51PNCK0.95616373
52SGK20.94596013
53PRKCE0.93461358
54ERBB20.91912014
55CAMK1D0.91430273
56GRK10.91055681
57MAPK40.89070058
58KDR0.89030944
59SGK30.88603383
60ADRBK10.87653400
61WNK30.86071096
62PRKCZ0.85252182
63IKBKE0.82990978
64MAP2K60.80169491
65MAP2K30.79944317
66TAOK20.76738131
67MAP2K70.76640787
68MAP3K30.74446404
69GRK60.74265958
70PRKAA10.74063116
71BRSK20.72604760
72PRKACG0.71817764
73IRAK20.71666322
74DYRK20.70077428
75SGK2230.69957682
76SGK4940.69957682
77MET0.69509120
78CSK0.68576982
79GSK3A0.68054363
80NUAK10.67823398
81AKT30.66807424
82MAPK120.65008416
83DYRK1B0.63745824
84CDK60.63145266
85IRAK10.63078586
86MAPK70.62931371
87SIK20.62852705
88CAMK2G0.62789505
89GRK70.62100116
90EPHB10.62007065
91PRKCQ0.60198328
92WNK40.59821078
93PHKG10.59443337
94PHKG20.59443337
95FGFR30.58488949
96KIT0.56973273
97FER0.56480864
98PRKG10.55841030
99TEC0.55393497
100PTK20.52443406
101MUSK0.52270890
102SYK0.52176868
103TRPM70.51492150
104TNIK0.51220936
105PKN10.50846044
106MARK10.49595487
107CSNK1A10.49390768
108MKNK20.48348602
109IGF1R0.47206817
110CAMK1G0.45888809
111CSNK1D0.45336816
112STK110.45030041
113CSF1R0.44472934
114MAP3K130.44346489
115TRIB30.44252700
116PDPK10.44210067
117ERBB30.43419957
118TGFBR20.42592231
119BCR0.41102799
120MAP3K50.39548927
121CSNK1G10.39107241
122PRKCG0.38865526
123MARK30.38686053
124CAMK2A0.38288805
125CHUK0.38241629
126LYN0.38231536
127VRK10.38049972
128MATK0.37795374
129RPS6KA50.37384211
130CAMK40.36338768
131PRKACB0.35060485
132STK160.34864598
133CSNK1G20.34725400
134NLK0.34619729
135PDK20.33433178
136MAP3K110.31358713
137MAPKAPK50.30852583
138PRKCA0.30623099
139EIF2AK20.28995535
140IRAK40.27667512
141MAP3K100.27364329
142MAP3K10.26812694
143ADRBK20.26209328
144JAK30.25956112
145PIK3CA0.24846891
146MAPK30.23568616
147PDK10.23521998
148PRKACA0.23072583
149IKBKB0.22286705
150RPS6KB10.22105505
151ABL10.21608636
152OXSR10.21102374

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.44516543
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40913310
3Nitrogen metabolism_Homo sapiens_hsa009103.38229845
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.25596492
5Arginine biosynthesis_Homo sapiens_hsa002202.95624585
6Tryptophan metabolism_Homo sapiens_hsa003802.81519650
7Complement and coagulation cascades_Homo sapiens_hsa046102.68191886
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62830518
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57899015
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51393068
11Fatty acid degradation_Homo sapiens_hsa000712.49000003
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46384113
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.39879223
14Butanoate metabolism_Homo sapiens_hsa006502.22814221
15Peroxisome_Homo sapiens_hsa041462.18376021
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.18016912
17Steroid hormone biosynthesis_Homo sapiens_hsa001402.03301889
18Propanoate metabolism_Homo sapiens_hsa006401.97796184
19Histidine metabolism_Homo sapiens_hsa003401.96392523
20Chemical carcinogenesis_Homo sapiens_hsa052041.95520893
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94242655
22PPAR signaling pathway_Homo sapiens_hsa033201.81980390
23Fatty acid metabolism_Homo sapiens_hsa012121.79196864
24Retinol metabolism_Homo sapiens_hsa008301.77870521
25Caffeine metabolism_Homo sapiens_hsa002321.72232069
26Staphylococcus aureus infection_Homo sapiens_hsa051501.70998506
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68391664
28* beta-Alanine metabolism_Homo sapiens_hsa004101.64027551
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63976246
30* Drug metabolism - other enzymes_Homo sapiens_hsa009831.63035761
31Selenocompound metabolism_Homo sapiens_hsa004501.62696084
32Phenylalanine metabolism_Homo sapiens_hsa003601.61191796
33Sulfur metabolism_Homo sapiens_hsa009201.51977964
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49206300
35Bile secretion_Homo sapiens_hsa049761.48695614
36Tyrosine metabolism_Homo sapiens_hsa003501.47028413
37* Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43903731
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40539648
39Fatty acid elongation_Homo sapiens_hsa000621.35219398
40Starch and sucrose metabolism_Homo sapiens_hsa005001.34033593
41Pyruvate metabolism_Homo sapiens_hsa006201.32499066
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.32201427
43ABC transporters_Homo sapiens_hsa020101.27968913
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.25274781
45Folate biosynthesis_Homo sapiens_hsa007901.22763172
46Steroid biosynthesis_Homo sapiens_hsa001001.22678544
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18077779
48Fat digestion and absorption_Homo sapiens_hsa049751.09326696
49Biosynthesis of amino acids_Homo sapiens_hsa012301.07695889
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.04292023
51Carbon metabolism_Homo sapiens_hsa012001.03431841
52Vitamin digestion and absorption_Homo sapiens_hsa049771.00633783
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00072212
54Arginine and proline metabolism_Homo sapiens_hsa003301.00055995
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95280127
56Vitamin B6 metabolism_Homo sapiens_hsa007500.94386429
57Sulfur relay system_Homo sapiens_hsa041220.91127029
58Lysine degradation_Homo sapiens_hsa003100.87080788
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86539286
60One carbon pool by folate_Homo sapiens_hsa006700.77285810
61Glycerolipid metabolism_Homo sapiens_hsa005610.66439803
62Glutathione metabolism_Homo sapiens_hsa004800.66185990
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62710790
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53729593
65Phototransduction_Homo sapiens_hsa047440.51212708
66Pentose phosphate pathway_Homo sapiens_hsa000300.49966112
67* Metabolic pathways_Homo sapiens_hsa011000.48749131
68Fatty acid biosynthesis_Homo sapiens_hsa000610.47813307
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40953890
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39822053
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38093968
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35428427
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30593820
74Prion diseases_Homo sapiens_hsa050200.28522067
75Linoleic acid metabolism_Homo sapiens_hsa005910.28108699
76Galactose metabolism_Homo sapiens_hsa000520.25312186
77Serotonergic synapse_Homo sapiens_hsa047260.24968678
78Pertussis_Homo sapiens_hsa051330.24631998
79Fructose and mannose metabolism_Homo sapiens_hsa000510.23732573
80Insulin resistance_Homo sapiens_hsa049310.20997171
81Oxidative phosphorylation_Homo sapiens_hsa001900.17576090
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17331289
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.16910852
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15538618
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.14018041
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.14006547
87Nicotine addiction_Homo sapiens_hsa050330.13190832
88Protein export_Homo sapiens_hsa030600.12889531
89Graft-versus-host disease_Homo sapiens_hsa053320.11604200
90Circadian rhythm_Homo sapiens_hsa047100.09957472
91Glucagon signaling pathway_Homo sapiens_hsa049220.07450064
92Type I diabetes mellitus_Homo sapiens_hsa049400.06507146
93GABAergic synapse_Homo sapiens_hsa047270.03467546
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.01786618
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.01218019
96Lysosome_Homo sapiens_hsa04142-0.2420742
97Mineral absorption_Homo sapiens_hsa04978-0.2418413
98Other glycan degradation_Homo sapiens_hsa00511-0.2303506
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2171459
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2081335
101Ether lipid metabolism_Homo sapiens_hsa00565-0.2078532
102Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1961945
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1842405
104Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1809296
105Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1788745
106African trypanosomiasis_Homo sapiens_hsa05143-0.1561456
107Hepatitis C_Homo sapiens_hsa05160-0.1559847
108Insulin signaling pathway_Homo sapiens_hsa04910-0.1456916
109Renin-angiotensin system_Homo sapiens_hsa04614-0.1434120
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0803193
111Regulation of autophagy_Homo sapiens_hsa04140-0.0762566
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0641269
113Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0570031
114AMPK signaling pathway_Homo sapiens_hsa04152-0.0313099
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0277626
116Homologous recombination_Homo sapiens_hsa03440-0.0202584
117Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0179044
118Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0136208
119Parkinsons disease_Homo sapiens_hsa05012-0.0061964
120Basal transcription factors_Homo sapiens_hsa03022-0.0048049

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