UPF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)6.44222712
2nuclear pore complex assembly (GO:0051292)5.38898433
3nuclear pore organization (GO:0006999)4.93167162
4histone H3-K4 trimethylation (GO:0080182)4.53022379
5regulation of DNA endoreduplication (GO:0032875)4.43130805
6protein-cofactor linkage (GO:0018065)4.38695285
7negative regulation of histone methylation (GO:0031061)4.36177942
8proline transport (GO:0015824)4.33895070
9pre-miRNA processing (GO:0031054)4.33128498
10cytoplasmic mRNA processing body assembly (GO:0033962)4.28082874
11regulation of RNA export from nucleus (GO:0046831)4.25320047
12protein localization to kinetochore (GO:0034501)4.12540201
13centriole replication (GO:0007099)4.03249183
14positive regulation of mitotic sister chromatid separation (GO:1901970)4.02324729
15positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.02324729
16positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.02324729
17viral transcription (GO:0019083)4.02077571
18translational termination (GO:0006415)4.01170175
19histone H3-K4 methylation (GO:0051568)3.99297291
20regulation of nuclear cell cycle DNA replication (GO:0033262)3.98182385
21ribosomal small subunit biogenesis (GO:0042274)3.91350893
22pore complex assembly (GO:0046931)3.90300806
23regulation of histone H3-K9 methylation (GO:0051570)3.84576823
24negative regulation of DNA-dependent DNA replication (GO:2000104)3.83545578
25histone H3-K9 methylation (GO:0051567)3.79026858
26chromatin remodeling at centromere (GO:0031055)3.71687157
27regulation of nucleobase-containing compound transport (GO:0032239)3.66071584
28sister chromatid cohesion (GO:0007062)3.65775438
29histone H3-K9 demethylation (GO:0033169)3.57087849
30peptidyl-lysine trimethylation (GO:0018023)3.56792207
31piRNA metabolic process (GO:0034587)3.56617567
32ribosomal small subunit assembly (GO:0000028)3.55457033
33regulation of histone H3-K4 methylation (GO:0051569)3.53634927
34CENP-A containing nucleosome assembly (GO:0034080)3.53405651
35maturation of SSU-rRNA (GO:0030490)3.53377446
36sister chromatid segregation (GO:0000819)3.51227212
37chromatin assembly (GO:0031497)3.49764317
38protein targeting to Golgi (GO:0000042)3.48707488
39protein localization to chromosome, centromeric region (GO:0071459)3.44383088
40establishment of protein localization to Golgi (GO:0072600)3.44068173
41activated T cell proliferation (GO:0050798)3.40897538
42histone H4-K12 acetylation (GO:0043983)3.40092329
43mitotic sister chromatid segregation (GO:0000070)3.39215741
44negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.39120593
45ribosomal large subunit biogenesis (GO:0042273)3.36722389
46regulation of histone methylation (GO:0031060)3.36208115
47cotranslational protein targeting to membrane (GO:0006613)3.32045329
48histone lysine methylation (GO:0034968)3.31456156
49histone H4-K16 acetylation (GO:0043984)3.30908130
50regulation of sister chromatid cohesion (GO:0007063)3.30803463
51chaperone-mediated protein transport (GO:0072321)3.29747795
52histone H3-K9 modification (GO:0061647)3.25320344
53alternative mRNA splicing, via spliceosome (GO:0000380)3.24821409
54histone H3-K36 demethylation (GO:0070544)3.22924849
55histone exchange (GO:0043486)3.22294650
56translational elongation (GO:0006414)3.20898196
57mitotic chromosome condensation (GO:0007076)3.20876142
58translational initiation (GO:0006413)3.19447655
59reciprocal meiotic recombination (GO:0007131)3.19065015
60reciprocal DNA recombination (GO:0035825)3.19065015
61negative regulation of translation, ncRNA-mediated (GO:0040033)3.18981434
62regulation of translation, ncRNA-mediated (GO:0045974)3.18981434
63negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.18981434
64NLS-bearing protein import into nucleus (GO:0006607)3.18242931
65organelle disassembly (GO:1903008)3.18163581
66retrograde transport, vesicle recycling within Golgi (GO:0000301)3.17469555
67DNA double-strand break processing (GO:0000729)3.16243899
68* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.15091593
69SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.13523442
70ribonucleoprotein complex disassembly (GO:0032988)3.12522908
71histone lysine demethylation (GO:0070076)3.12373652
72rRNA modification (GO:0000154)3.11898267
73ribonucleoprotein complex biogenesis (GO:0022613)3.10880616
74regulation of mitotic spindle organization (GO:0060236)3.10584442
75protein targeting to ER (GO:0045047)3.10345620
76regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.08535595
77positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.08535595
78stress granule assembly (GO:0034063)3.07983495
79mRNA splice site selection (GO:0006376)3.06597195
80centriole assembly (GO:0098534)3.04376334
81positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.03108783
82regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.03108783
83heterochromatin organization (GO:0070828)3.01623935
84meiotic chromosome segregation (GO:0045132)3.00437429
85mitotic metaphase plate congression (GO:0007080)2.99174584
86positive regulation of chromosome segregation (GO:0051984)2.98635450
87double-strand break repair via homologous recombination (GO:0000724)2.96841417
88establishment of protein localization to endoplasmic reticulum (GO:0072599)2.96715136
89mRNA stabilization (GO:0048255)2.95746451
90RNA stabilization (GO:0043489)2.95746451
91histone H4-K8 acetylation (GO:0043982)2.94412690
92histone H4-K5 acetylation (GO:0043981)2.94412690
93DNA methylation involved in gamete generation (GO:0043046)2.93774002
94cellular protein complex disassembly (GO:0043624)2.93460393
95negative regulation of histone modification (GO:0031057)2.93158642
96glucocorticoid receptor signaling pathway (GO:0042921)2.91427029
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91022115
98telomere maintenance via telomerase (GO:0007004)2.90847816
99somatic hypermutation of immunoglobulin genes (GO:0016446)2.90009551
100somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90009551
101DNA replication checkpoint (GO:0000076)2.89823201
102recombinational repair (GO:0000725)2.89697168
103negative regulation of chromatin modification (GO:1903309)2.89667195
104viral life cycle (GO:0019058)2.89500711
105histone demethylation (GO:0016577)2.89424503
106nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83938475
107positive regulation of mRNA catabolic process (GO:0061014)2.83380455
108histone methylation (GO:0016571)2.81714625
109regulation of helicase activity (GO:0051095)2.80550547
110metaphase plate congression (GO:0051310)2.80533432
111ribosome biogenesis (GO:0042254)2.80178196
112kinetochore organization (GO:0051383)2.79264358
113regulation of spindle organization (GO:0090224)2.78512430
114DNA replication-independent nucleosome organization (GO:0034724)2.78250169
115DNA replication-independent nucleosome assembly (GO:0006336)2.78250169
116monoubiquitinated protein deubiquitination (GO:0035520)2.78046814
117protein localization to endoplasmic reticulum (GO:0070972)2.77855894
118* nuclear-transcribed mRNA catabolic process (GO:0000956)2.77552640
119DNA topological change (GO:0006265)2.77488506
120negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.76573084
121DNA duplex unwinding (GO:0032508)2.75892143
122histone H2A monoubiquitination (GO:0035518)2.75240244
123DNA geometric change (GO:0032392)2.73318852
124interkinetic nuclear migration (GO:0022027)2.72883157
125spliceosomal complex assembly (GO:0000245)2.72057559
126positive regulation of histone H3-K4 methylation (GO:0051571)2.71941832
127regulation of mRNA 3-end processing (GO:0031440)2.71934555
128peptidyl-lysine methylation (GO:0018022)2.70743034
129positive regulation of DNA-templated transcription, initiation (GO:2000144)2.70413793
130rRNA methylation (GO:0031167)2.69665070
131regulation of meiosis I (GO:0060631)2.69390732
132rRNA metabolic process (GO:0016072)2.69205002
133protein localization to chromosome (GO:0034502)2.67787843
134* mRNA catabolic process (GO:0006402)2.65581996
135macromolecular complex disassembly (GO:0032984)2.65540626
136negative regulation of fibroblast apoptotic process (GO:2000270)2.64044959
137regulation of telomere maintenance (GO:0032204)2.63640255
138regulation of centriole replication (GO:0046599)2.63488488
139rRNA processing (GO:0006364)2.63262411
140* RNA catabolic process (GO:0006401)2.62268190
141protein complex disassembly (GO:0043241)2.61954192
142regulation of DNA-dependent DNA replication (GO:0090329)2.61763195
143positive regulation of mRNA metabolic process (GO:1903313)2.61607273
144regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.60728525
145positive regulation of mRNA 3-end processing (GO:0031442)2.60641522
146cellular component biogenesis (GO:0044085)2.59639996
147intra-S DNA damage checkpoint (GO:0031573)2.59510086
148ribosome assembly (GO:0042255)2.58304815
149DNA methylation (GO:0006306)2.57589298
150DNA alkylation (GO:0006305)2.57589298
151protein demethylation (GO:0006482)2.56786347
152protein dealkylation (GO:0008214)2.56786347
153protein K48-linked deubiquitination (GO:0071108)2.56704119
154CTP metabolic process (GO:0046036)2.56349156
155CTP biosynthetic process (GO:0006241)2.56349156
156regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.55693677
157mitotic recombination (GO:0006312)2.55451568
158positive regulation of histone methylation (GO:0031062)2.55383516
159striated muscle atrophy (GO:0014891)2.54475354
160regulation of histone H3-K27 methylation (GO:0061085)2.53978092
161regulation of mRNA stability (GO:0043488)2.53931739
162negative regulation of DNA recombination (GO:0045910)2.53819304
163male meiosis I (GO:0007141)2.52646623
164histone mRNA metabolic process (GO:0008334)2.51297427
165corticosteroid receptor signaling pathway (GO:0031958)2.51065162
166positive regulation of mRNA processing (GO:0050685)2.50536408
167positive regulation of gene expression, epigenetic (GO:0045815)2.50313351
168regulation of gene expression by genetic imprinting (GO:0006349)2.48907767
169ventricular system development (GO:0021591)2.48889432
170positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.47296067
171mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.47296067
172import into cell (GO:0098657)2.46788807
173negative regulation of DNA repair (GO:0045738)2.46239740
174nucleotide-excision repair, DNA gap filling (GO:0006297)2.45751935
175translesion synthesis (GO:0019985)2.44200605
176kinetochore assembly (GO:0051382)2.42563606
177ncRNA catabolic process (GO:0034661)2.41037034
178mitotic G2/M transition checkpoint (GO:0044818)2.40855566
179somatic recombination of immunoglobulin gene segments (GO:0016447)2.40481569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.36196353
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.87297773
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.14880611
4KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.32576618
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32345162
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.24810863
7* EST1_17652178_ChIP-ChIP_JURKAT_Human2.76046643
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.61147952
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.47477952
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.44790373
11* VDR_23849224_ChIP-Seq_CD4+_Human2.38509336
12* ELK1_19687146_ChIP-ChIP_HELA_Human2.31301975
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.24038276
14FOXP3_21729870_ChIP-Seq_TREG_Human2.20301169
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.16878739
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09235665
17* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.07938217
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07714670
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06145790
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02093620
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.00628506
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.00628506
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.00628506
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99332575
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97862294
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.96601274
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92160194
28FUS_26573619_Chip-Seq_HEK293_Human1.91965800
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.89076153
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.86439969
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86390366
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.83758435
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78336596
34* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.75890485
35TCF4_18268006_ChIP-ChIP_LS174T_Human1.73558939
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72758512
37FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.68539461
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66353840
39* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66257986
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.65760400
41ZNF274_21170338_ChIP-Seq_K562_Hela1.64290077
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61492784
43HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58890248
44AR_21909140_ChIP-Seq_LNCAP_Human1.56555575
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.55339137
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53741581
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52183573
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.46862302
49TP53_16413492_ChIP-PET_HCT116_Human1.45209212
50* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40544423
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40439146
52MYC_18940864_ChIP-ChIP_HL60_Human1.38973733
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37871641
54KDM5A_27292631_Chip-Seq_BREAST_Human1.37155317
55EWS_26573619_Chip-Seq_HEK293_Human1.35459042
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33892615
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32212435
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31458014
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30461705
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26893239
61* STAT3_23295773_ChIP-Seq_U87_Human1.26556069
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.25978408
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25586862
64* MYB_26560356_Chip-Seq_TH2_Human1.24151057
65* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23378387
66TTF2_22483619_ChIP-Seq_HELA_Human1.22096097
67MYC_22102868_ChIP-Seq_BL_Human1.21162274
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.21069246
69* SPI1_23547873_ChIP-Seq_NB4_Human1.20518881
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18109429
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17417633
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17120044
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16947806
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16162098
75GATA3_26560356_Chip-Seq_TH2_Human1.15628101
76TCF4_23295773_ChIP-Seq_U87_Human1.15479404
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15057400
78IRF1_19129219_ChIP-ChIP_H3396_Human1.14558916
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12215221
80TP53_22573176_ChIP-Seq_HFKS_Human1.11708217
81TCF7_22412390_ChIP-Seq_EML_Mouse1.11457765
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10329095
83IGF1R_20145208_ChIP-Seq_DFB_Human1.10201094
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09517587
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08794923
86* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08729571
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08668902
88* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08325596
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08196084
90SMAD4_21799915_ChIP-Seq_A2780_Human1.06746954
91IRF8_21731497_ChIP-ChIP_J774_Mouse1.05901858
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05032073
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04355017
94BP1_19119308_ChIP-ChIP_Hs578T_Human1.03904983
95TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03759877
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.03200454
97CIITA_25753668_ChIP-Seq_RAJI_Human1.02706602
98CBP_20019798_ChIP-Seq_JUKART_Human1.02550888
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02550888
100TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02426474
101* E2F1_18555785_Chip-Seq_ESCs_Mouse1.02088084
102MYB_26560356_Chip-Seq_TH1_Human1.01632832
103EZH2_22144423_ChIP-Seq_EOC_Human1.00763552
104ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00119730
105ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00112542
106STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99995857
107MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99775923
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99525783
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99291631
110RARB_27405468_Chip-Seq_BRAIN_Mouse0.96976481
111HOXB7_26014856_ChIP-Seq_BT474_Human0.96742780
112* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96570930
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96455199
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96154102
115VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95546104
116NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94893634
117YY1_21170310_ChIP-Seq_MESCs_Mouse0.94883000
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94716450
119SMAD_19615063_ChIP-ChIP_OVARY_Human0.94548147
120ETV1_20927104_ChIP-Seq_GIST48_Human0.94443521
121DCP1A_22483619_ChIP-Seq_HELA_Human0.94291282
122PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93128617
123MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92485844
124SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92391595
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92301788
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92301788
127TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90413887
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89386798
129MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88673725
130* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87782925
131GATA1_22025678_ChIP-Seq_K562_Human0.87499174
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87329587
133FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87036207
134ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86452106
135* NANOG_18555785_Chip-Seq_ESCs_Mouse0.86008085
136CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.85601583
137* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85553639
138TAF15_26573619_Chip-Seq_HEK293_Human0.84965413
139* SMRT_27268052_Chip-Seq_Bcells_Human0.84816891
140RNF2_27304074_Chip-Seq_NSC_Mouse0.84642484
141YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83390386
142CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83190119
143OCT4_18555785_Chip-Seq_ESCs_Mouse0.82841442
144GATA1_26923725_Chip-Seq_HPCs_Mouse0.82117298
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81987125
146POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.81772114
147* P300_18555785_Chip-Seq_ESCs_Mouse0.81483496
148SRF_21415370_ChIP-Seq_HL-1_Mouse0.81291495
149GATA3_27048872_Chip-Seq_THYMUS_Human0.80348193
150ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80068087
151PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79070560
152FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.78442323
153FOXO3_23340844_ChIP-Seq_DLD1_Human0.77653966
154EZH2_27294783_Chip-Seq_NPCs_Mouse0.77413897
155SCL_19346495_ChIP-Seq_HPC-7_Human0.76837611
156CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75772546
157STAT3_18555785_ChIP-Seq_MESCs_Mouse0.75602948
158CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.75193803
159ISL1_27105846_Chip-Seq_CPCs_Mouse0.75110261
160* AR_19668381_ChIP-Seq_PC3_Human0.74638823
161ER_23166858_ChIP-Seq_MCF-7_Human0.73518030

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.94725903
2MP0003787_abnormal_imprinting4.80458379
3MP0000569_abnormal_digit_pigmentation4.76330884
4MP0008877_abnormal_DNA_methylation4.16500932
5MP0009379_abnormal_foot_pigmentation3.24143341
6MP0002009_preneoplasia3.16599193
7MP0003121_genomic_imprinting2.92698227
8MP0010352_gastrointestinal_tract_polyps2.81503887
9MP0003111_abnormal_nucleus_morphology2.66578023
10MP0010094_abnormal_chromosome_stability2.61725494
11MP0004264_abnormal_extraembryonic_tissu2.60472027
12MP0003123_paternal_imprinting2.49786156
13MP0004957_abnormal_blastocyst_morpholog2.47057392
14MP0003890_abnormal_embryonic-extraembry2.33500306
15MP0003693_abnormal_embryo_hatching2.19442250
16MP0003077_abnormal_cell_cycle2.17974255
17MP0003122_maternal_imprinting2.08210619
18MP0005076_abnormal_cell_differentiation1.99938779
19MP0004808_abnormal_hematopoietic_stem1.99421754
20MP0010307_abnormal_tumor_latency1.98906837
21MP0000685_abnormal_immune_system1.87667493
22MP0002396_abnormal_hematopoietic_system1.79900026
23MP0004130_abnormal_muscle_cell1.76833624
24MP0001835_abnormal_antigen_presentation1.76433241
25MP0001800_abnormal_humoral_immune1.70928210
26MP0010234_abnormal_vibrissa_follicle1.68608753
27MP0004147_increased_porphyrin_level1.64242725
28MP0002877_abnormal_melanocyte_morpholog1.58806484
29MP0004142_abnormal_muscle_tone1.55049240
30MP0002084_abnormal_developmental_patter1.50579719
31MP0005623_abnormal_meninges_morphology1.50372151
32MP0008007_abnormal_cellular_replicative1.49741640
33MP0008058_abnormal_DNA_repair1.48038387
34MP0001672_abnormal_embryogenesis/_devel1.47425589
35MP0005380_embryogenesis_phenotype1.47425589
36MP0000350_abnormal_cell_proliferation1.45018356
37MP0002166_altered_tumor_susceptibility1.42434242
38MP0004197_abnormal_fetal_growth/weight/1.40089966
39MP0003984_embryonic_growth_retardation1.38321179
40MP0002088_abnormal_embryonic_growth/wei1.38028325
41MP0009780_abnormal_chondrocyte_physiolo1.35676482
42MP0002006_tumorigenesis1.33461357
43MP0003045_fibrosis1.28627861
44MP0001790_abnormal_immune_system1.28449013
45MP0005387_immune_system_phenotype1.28449013
46MP0002086_abnormal_extraembryonic_tissu1.27529591
47MP0009703_decreased_birth_body1.26808144
48MP0000689_abnormal_spleen_morphology1.26060185
49MP0001919_abnormal_reproductive_system1.25063549
50MP0001730_embryonic_growth_arrest1.24862330
51MP0006035_abnormal_mitochondrial_morpho1.24616298
52MP0002723_abnormal_immune_serum1.22839565
53MP0004185_abnormal_adipocyte_glucose1.22073036
54MP0000427_abnormal_hair_cycle1.21992315
55MP0002163_abnormal_gland_morphology1.19675165
56MP0005379_endocrine/exocrine_gland_phen1.19064093
57MP0005310_abnormal_salivary_gland1.18926133
58MP0008995_early_reproductive_senescence1.18532125
59MP0002420_abnormal_adaptive_immunity1.16072601
60MP0005645_abnormal_hypothalamus_physiol1.15759605
61MP0003300_gastrointestinal_ulcer1.15306672
62MP0005174_abnormal_tail_pigmentation1.15305041
63MP0001819_abnormal_immune_cell1.14043210
64MP0002085_abnormal_embryonic_tissue1.13751167
65MP0002452_abnormal_antigen_presenting1.13596025
66MP0006072_abnormal_retinal_apoptosis1.11984686
67MP0000716_abnormal_immune_system1.11729742
68MP0002138_abnormal_hepatobiliary_system1.08879182
69MP0000631_abnormal_neuroendocrine_gland1.08173648
70MP0001929_abnormal_gametogenesis1.08173631
71MP0002722_abnormal_immune_system1.07601589
72MP0001697_abnormal_embryo_size1.07297465
73MP0000703_abnormal_thymus_morphology1.06420058
74MP0009278_abnormal_bone_marrow1.04063352
75MP0004859_abnormal_synaptic_plasticity1.02793982
76MP0005084_abnormal_gallbladder_morpholo1.02666488
77MP0002928_abnormal_bile_duct1.01182829
78MP0003718_maternal_effect1.00112474
79MP0001188_hyperpigmentation0.99508914
80MP0002210_abnormal_sex_determination0.98244539
81MP0002429_abnormal_blood_cell0.97047018
82MP0005389_reproductive_system_phenotype0.95169283
83MP0003698_abnormal_male_reproductive0.94696435
84MP0002405_respiratory_system_inflammati0.94605410
85MP0002095_abnormal_skin_pigmentation0.92761860
86MP0001145_abnormal_male_reproductive0.92362553
87MP0000432_abnormal_head_morphology0.91693850
88MP0005397_hematopoietic_system_phenotyp0.91367719
89MP0001545_abnormal_hematopoietic_system0.91367719
90MP0003937_abnormal_limbs/digits/tail_de0.89959888
91MP0004742_abnormal_vestibular_system0.85338744
92MP0002876_abnormal_thyroid_physiology0.85234577
93MP0006036_abnormal_mitochondrial_physio0.84915778
94MP0003935_abnormal_craniofacial_develop0.84102693
95MP0003656_abnormal_erythrocyte_physiolo0.83805334
96MP0002398_abnormal_bone_marrow0.83370646
97MP0009115_abnormal_fat_cell0.83050306
98MP0003567_abnormal_fetal_cardiomyocyte0.83002510
99MP0009765_abnormal_xenobiotic_induced0.82158687
100MP0010678_abnormal_skin_adnexa0.81660290
101MP0008770_decreased_survivor_rate0.80489625
102* MP0002080_prenatal_lethality0.80030858
103MP0004145_abnormal_muscle_electrophysio0.79958486
104MP0008961_abnormal_basal_metabolism0.79407240
105MP0009785_altered_susceptibility_to0.78180774
106MP0000653_abnormal_sex_gland0.78164286
107MP0002148_abnormal_hypersensitivity_rea0.78036020
108MP0002925_abnormal_cardiovascular_devel0.76933462
109MP0003786_premature_aging0.76784600
110MP0000313_abnormal_cell_death0.76660547
111MP0002160_abnormal_reproductive_system0.75119958
112MP0006292_abnormal_olfactory_placode0.74601527
113MP0002277_abnormal_respiratory_mucosa0.74183496
114MP0003763_abnormal_thymus_physiology0.73991768
115MP0001485_abnormal_pinna_reflex0.73756100
116MP0001851_eye_inflammation0.73467566
117MP0006276_abnormal_autonomic_nervous0.71149893
118MP0005551_abnormal_eye_electrophysiolog0.71106975
119MP0005000_abnormal_immune_tolerance0.69417092
120MP0001501_abnormal_sleep_pattern0.68302276
121MP0004270_analgesia0.67259559
122MP0005386_behavior/neurological_phenoty0.66325012
123MP0004924_abnormal_behavior0.66325012
124MP0003755_abnormal_palate_morphology0.66206836
125MP0008932_abnormal_embryonic_tissue0.65765152
126MP0005451_abnormal_body_composition0.65442226
127MP0001784_abnormal_fluid_regulation0.65323520
128MP0008872_abnormal_physiological_respon0.65225352
129MP0001849_ear_inflammation0.64939709
130MP0005075_abnormal_melanosome_morpholog0.64868026
131MP0003880_abnormal_central_pattern0.64229246
132MP0000490_abnormal_crypts_of0.62356795
133MP0005671_abnormal_response_to0.61809810
134MP0002127_abnormal_cardiovascular_syste0.61565150
135MP0003119_abnormal_digestive_system0.61299981
136MP0002114_abnormal_axial_skeleton0.61135539
137MP0000428_abnormal_craniofacial_morphol0.60939980
138MP0009672_abnormal_birth_weight0.60293275
139MP0000516_abnormal_urinary_system0.60145514
140MP0005367_renal/urinary_system_phenotyp0.60145514
141MP0000003_abnormal_adipose_tissue0.58659754
142MP0002019_abnormal_tumor_incidence0.57701653
143MP0005621_abnormal_cell_physiology0.56384562
144MP0001286_abnormal_eye_development0.55437155
145MP0002233_abnormal_nose_morphology0.53616153
146MP0001293_anophthalmia0.53238776
147MP0003861_abnormal_nervous_system0.53163296
148MP0003936_abnormal_reproductive_system0.52779873
149MP0003315_abnormal_perineum_morphology0.50760138
150MP0002081_perinatal_lethality0.50754927

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)5.76631535
2Abnormality of the fingertips (HP:0001211)3.95596827
3Abnormality of cells of the erythroid lineage (HP:0012130)3.63891542
4Hypochromic microcytic anemia (HP:0004840)3.43806301
5Macroorchidism (HP:0000053)3.35311134
6Abnormal number of erythroid precursors (HP:0012131)3.14109467
7Truncal obesity (HP:0001956)3.03257436
8Genetic anticipation (HP:0003743)3.00149156
9Chromsome breakage (HP:0040012)2.98537040
10Reticulocytopenia (HP:0001896)2.96261847
11Ependymoma (HP:0002888)2.90265864
12Aplasia/Hypoplasia of the uvula (HP:0010293)2.86665946
13Urethral obstruction (HP:0000796)2.84024153
14Abnormality of the renal cortex (HP:0011035)2.79537516
15Pancreatic fibrosis (HP:0100732)2.78664574
16Pallor (HP:0000980)2.73252910
17Neuroendocrine neoplasm (HP:0100634)2.68770082
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.66438097
19Meckel diverticulum (HP:0002245)2.65791552
20Abnormality of the ileum (HP:0001549)2.62355458
21Autoimmune hemolytic anemia (HP:0001890)2.60579869
22Asplenia (HP:0001746)2.50832135
23Aplasia/Hypoplasia of the spleen (HP:0010451)2.47899500
24Supernumerary ribs (HP:0005815)2.46162457
25Lip pit (HP:0100267)2.45356806
26Anal stenosis (HP:0002025)2.44911266
27Macrocytic anemia (HP:0001972)2.43183982
28Increased nuchal translucency (HP:0010880)2.43007555
29Microvesicular hepatic steatosis (HP:0001414)2.39871960
30Myokymia (HP:0002411)2.39692576
31Hypoplasia of the pons (HP:0012110)2.38717430
32Pancreatic cysts (HP:0001737)2.37603607
33Astrocytoma (HP:0009592)2.37241036
34Abnormality of the astrocytes (HP:0100707)2.37241036
35Long eyelashes (HP:0000527)2.36277116
36Absent frontal sinuses (HP:0002688)2.35895886
37Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32770420
38Absent thumb (HP:0009777)2.32573906
39Abnormality of the pons (HP:0007361)2.32238047
40Clubbing of toes (HP:0100760)2.31876314
41Abnormality of chromosome stability (HP:0003220)2.30154222
42Rhabdomyosarcoma (HP:0002859)2.30145434
43Glioma (HP:0009733)2.24401021
44Medulloblastoma (HP:0002885)2.21288098
45Small intestinal stenosis (HP:0012848)2.20936799
46Duodenal stenosis (HP:0100867)2.20936799
47Supernumerary bones of the axial skeleton (HP:0009144)2.18444054
48Tubulointerstitial nephritis (HP:0001970)2.18107104
49Ankyloglossia (HP:0010296)2.17761487
50Tinnitus (HP:0000360)2.15532875
51Acute lymphatic leukemia (HP:0006721)2.15433573
52Dysmetric saccades (HP:0000641)2.15358416
53Neoplasm of striated muscle (HP:0009728)2.14005395
54Prominent nose (HP:0000448)2.13167358
55Abnormality of DNA repair (HP:0003254)2.12282010
56Obsessive-compulsive behavior (HP:0000722)2.10582897
57Neoplasm of the adrenal cortex (HP:0100641)2.08850515
58Narrow palate (HP:0000189)2.08845812
59Abnormality of the lower motor neuron (HP:0002366)2.08458130
60Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.07457991
61Stenosis of the external auditory canal (HP:0000402)2.06714132
62Panhypogammaglobulinemia (HP:0003139)2.05867761
63Heterotopia (HP:0002282)2.05309912
643-Methylglutaconic aciduria (HP:0003535)2.03805710
65Birth length less than 3rd percentile (HP:0003561)2.03733431
66Abnormality of B cell number (HP:0010975)2.03516308
67Papilledema (HP:0001085)2.03500322
68Tapered finger (HP:0001182)2.03228159
69Biliary tract neoplasm (HP:0100574)2.03107860
70Cellular immunodeficiency (HP:0005374)2.02970138
71Proximal placement of thumb (HP:0009623)2.02048458
72Acute myeloid leukemia (HP:0004808)2.00339991
73IgG deficiency (HP:0004315)2.00327881
74Impaired smooth pursuit (HP:0007772)2.00173294
75Aplasia/Hypoplasia of the thymus (HP:0010515)1.97392593
76Sloping forehead (HP:0000340)1.95005821
77Abnormality of the nasal septum (HP:0000419)1.94598759
78Agammaglobulinemia (HP:0004432)1.94479602
79Aplasia/Hypoplasia of the sternum (HP:0006714)1.93886962
80Abnormality of the carotid arteries (HP:0005344)1.92688887
81Deep philtrum (HP:0002002)1.91083341
82Abnormality of the labia minora (HP:0012880)1.89896479
83Limb hypertonia (HP:0002509)1.89793261
84Diastasis recti (HP:0001540)1.89708565
85Abnormality of ocular smooth pursuit (HP:0000617)1.89603436
86Gonadotropin excess (HP:0000837)1.89391578
87Severe combined immunodeficiency (HP:0004430)1.89045135
88Abnormality of chromosome segregation (HP:0002916)1.88977657
89Abnormality of the duodenum (HP:0002246)1.88846957
90Nephroblastoma (Wilms tumor) (HP:0002667)1.88284178
91Supernumerary spleens (HP:0009799)1.88139479
92Broad palm (HP:0001169)1.86992968
93Oligodactyly (hands) (HP:0001180)1.85901801
94Horseshoe kidney (HP:0000085)1.85473739
95Myelodysplasia (HP:0002863)1.85386109
96Shawl scrotum (HP:0000049)1.85201019
97Neonatal hypoglycemia (HP:0001998)1.85137471
98Pendular nystagmus (HP:0012043)1.84974896
99Papillary thyroid carcinoma (HP:0002895)1.83695427
100Hypomagnesemia (HP:0002917)1.82944752
101Sandal gap (HP:0001852)1.82224893
102Rib fusion (HP:0000902)1.81645496
103Abnormal respiratory motile cilium physiology (HP:0012261)1.81189110
104Facial hemangioma (HP:0000329)1.81110799
105Abnormality of midbrain morphology (HP:0002418)1.80279182
106Molar tooth sign on MRI (HP:0002419)1.80279182
107Ectopic kidney (HP:0000086)1.79731668
108Renal cortical cysts (HP:0000803)1.79403518
109Abnormal ciliary motility (HP:0012262)1.79240401
110Vertebral arch anomaly (HP:0008438)1.78836494
111Stomach cancer (HP:0012126)1.78742246
112Abnormal hair whorl (HP:0010721)1.78278940
113Chronic bronchitis (HP:0004469)1.78022223
114Protruding tongue (HP:0010808)1.77938885
115Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.77750153
116Deviation of the thumb (HP:0009603)1.77727842
117Low anterior hairline (HP:0000294)1.77223992
118Hypoplasia of the thymus (HP:0000778)1.77162098
119Impulsivity (HP:0100710)1.76603152
120Embryonal renal neoplasm (HP:0011794)1.76555645
121Cleft eyelid (HP:0000625)1.75588585
122Attention deficit hyperactivity disorder (HP:0007018)1.75099792
123Cafe-au-lait spot (HP:0000957)1.75098693
124Hip dysplasia (HP:0001385)1.73486503
125B lymphocytopenia (HP:0010976)1.72958002
126Increased hepatocellular lipid droplets (HP:0006565)1.72758964
127Abnormality of oral frenula (HP:0000190)1.72388763
128Chronic hepatic failure (HP:0100626)1.72050370
129Septo-optic dysplasia (HP:0100842)1.71585059
130Hyperkalemia (HP:0002153)1.71024289
131Hypoplasia of the maxilla (HP:0000327)1.70878624
132Nephronophthisis (HP:0000090)1.70323562
133Malignant gastrointestinal tract tumors (HP:0006749)1.70316289
134Gastrointestinal carcinoma (HP:0002672)1.70316289
135Hypoplastic labia majora (HP:0000059)1.69844712
136Neoplasm of the oral cavity (HP:0100649)1.69770609
137Progressive cerebellar ataxia (HP:0002073)1.68153430
138Combined immunodeficiency (HP:0005387)1.68018144
139Short thumb (HP:0009778)1.67783511
140Thyroiditis (HP:0100646)1.67647937
141Submucous cleft hard palate (HP:0000176)1.67447514
142T lymphocytopenia (HP:0005403)1.67216681
143Abnormality of the frontal sinuses (HP:0002687)1.67016570
144Missing ribs (HP:0000921)1.66601096
145Rhinitis (HP:0012384)1.66110908
146Lipid accumulation in hepatocytes (HP:0006561)1.63463752
147Abnormality of T cell number (HP:0011839)1.62945745
148Acute necrotizing encephalopathy (HP:0006965)1.62913884
149Abnormality of the prostate (HP:0008775)1.62209616
150Neoplasm of the peripheral nervous system (HP:0100007)1.61570546
151Abnormality of the renal medulla (HP:0100957)1.61555462
152Abnormal biliary tract physiology (HP:0012439)1.60701002
153Bile duct proliferation (HP:0001408)1.60701002
154Aplasia/Hypoplasia of the earlobes (HP:0009906)1.60548573
155Transitional cell carcinoma of the bladder (HP:0006740)1.60481489
156Dynein arm defect of respiratory motile cilia (HP:0012255)1.60450220
157Absent/shortened dynein arms (HP:0200106)1.60450220
158Colon cancer (HP:0003003)1.58970532
159Triphalangeal thumb (HP:0001199)1.58541984
160Smooth philtrum (HP:0000319)1.57802769
161Dislocated radial head (HP:0003083)1.57232870
162Gaze-evoked nystagmus (HP:0000640)1.57079143
163Basal cell carcinoma (HP:0002671)1.56827812
164Resting tremor (HP:0002322)1.56743299
165Rectal prolapse (HP:0002035)1.56612493
166Hypochromic anemia (HP:0001931)1.56446291
167Abnormality of the preputium (HP:0100587)1.54529942
168Bronchiectasis (HP:0002110)1.54267849
169Oligodactyly (HP:0012165)1.53334474
170Abnormality of the labia majora (HP:0012881)1.53210927

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.17578830
2TNIK4.34040103
3STK163.47907548
4CDC73.30038377
5TAF12.70891619
6PNCK2.68358382
7TTK2.40396193
8VRK12.31773436
9BRD42.19265179
10LATS11.91699613
11MAP3K41.88117138
12TEC1.86380137
13PLK41.84926942
14MKNK21.82102885
15SIK21.81400879
16FRK1.78608066
17ALK1.75563852
18NUAK11.71610835
19CAMK1G1.67661509
20WNK31.61823170
21AKT31.61565879
22VRK21.57459727
23EIF2AK31.52556949
24WNK11.50586542
25BMPR1B1.50221280
26EIF2AK11.49738809
27CHEK11.45846556
28STK101.44319372
29RIPK41.42675301
30STK31.38508474
31MARK31.38107362
32ATR1.35835334
33NTRK31.35516775
34CDK71.30825412
35ATM1.30214731
36SRPK11.28007454
37OXSR11.25883511
38DMPK1.25727463
39MKNK11.20609601
40CDK61.16707955
41NLK1.15157528
42KIT1.13688758
43CDK41.13558391
44CAMK1D1.13280429
45GRK51.12943332
46BTK1.12686181
47EIF2AK21.11734891
48CSNK1E1.10331117
49IKBKE1.09581845
50DAPK21.08680170
51MST41.05787749
52PLK31.04455910
53CDK21.04209353
54TAOK31.02743588
55MAP4K21.02592701
56CHEK21.00811473
57NEK21.00777724
58CDK191.00159727
59WNK40.99676056
60CASK0.98272282
61STK40.97995928
62FGFR30.96287036
63MAPK100.94360941
64BRSK20.93872022
65MAPK140.90590296
66CDK10.88819023
67PLK10.84404838
68GSK3B0.83925043
69PINK10.82154630
70IKBKB0.81599703
71CDK80.81563937
72MTOR0.81545726
73PRKDC0.80804560
74JAK10.80804129
75PDGFRB0.80551370
76CDK90.80254719
77MAP2K40.79854423
78PRKD30.79741078
79EPHA40.78993932
80SGK10.78587024
81TYRO30.78162187
82GRK60.77468394
83STK110.77150344
84IRAK40.75890902
85CSNK1D0.75564008
86PIK3CG0.74062888
87MAP3K140.73968245
88UHMK10.73890635
89AURKB0.73315200
90PRKCI0.71027265
91SYK0.68448101
92WEE10.67850207
93GRK10.67276255
94TNK20.67167288
95PLK20.66764460
96MELK0.66422083
97ZAK0.66188041
98MAP3K20.65865503
99CDK30.64736065
100PRKCH0.63547175
101ACVR1B0.61810796
102SGK20.61090503
103RPS6KA30.60843921
104MARK20.60367566
105MAP4K10.58720330
106PRKG10.57339013
107SGK30.56405576
108AKT10.55798114
109HIPK20.54643449
110TXK0.53919868
111STK390.53263519
112STK380.53182168
113CHUK0.52988393
114PRKCQ0.52824409
115MAPK10.52441547
116INSRR0.50902849
117JAK30.50136004
118NEK10.50049853
119TSSK60.49868557
120SGK4940.49071199
121SGK2230.49071199
122PDK10.48846664
123MAPK80.47948319
124PASK0.47342045
125DYRK1A0.46162903
126ITK0.46057310
127PIM10.46049616
128RPS6KB10.45799963
129TRPM70.44355832
130CAMK40.43711244
131TRIB30.43303983
132LYN0.41760527
133MAP2K20.41647138
134PIK3CA0.41342729
135AKT20.40088848
136MAP3K100.38930714
137RPS6KB20.38422717
138PTK60.36953113
139MAP3K80.36845689
140CSNK2A20.35278674
141PAK20.34887775
142MAP3K70.34784669
143BMPR20.34198744
144FES0.33992817
145PDGFRA0.32824591

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.87184650
2DNA replication_Homo sapiens_hsa030302.66856133
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.46723319
4Nucleotide excision repair_Homo sapiens_hsa034202.28609961
5RNA polymerase_Homo sapiens_hsa030202.03772856
6Non-homologous end-joining_Homo sapiens_hsa034501.96137882
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90380239
8Fanconi anemia pathway_Homo sapiens_hsa034601.85173122
9* mRNA surveillance pathway_Homo sapiens_hsa030151.79113719
10One carbon pool by folate_Homo sapiens_hsa006701.76345705
11Protein export_Homo sapiens_hsa030601.70878415
12Parkinsons disease_Homo sapiens_hsa050121.68868213
13Dorso-ventral axis formation_Homo sapiens_hsa043201.68842771
14Oxidative phosphorylation_Homo sapiens_hsa001901.65816532
15Phosphatidylinositol signaling system_Homo sapiens_hsa040701.56396258
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55881184
17Asthma_Homo sapiens_hsa053101.53582339
18Long-term potentiation_Homo sapiens_hsa047201.53083099
19* RNA transport_Homo sapiens_hsa030131.48505742
20Cell cycle_Homo sapiens_hsa041101.42341572
21Spliceosome_Homo sapiens_hsa030401.31974405
22Huntingtons disease_Homo sapiens_hsa050161.26887617
23Inositol phosphate metabolism_Homo sapiens_hsa005621.26208213
24Nicotine addiction_Homo sapiens_hsa050331.25377333
25Amphetamine addiction_Homo sapiens_hsa050311.24773497
26Renin secretion_Homo sapiens_hsa049241.24467692
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21719418
28Basal transcription factors_Homo sapiens_hsa030221.21684097
29Type II diabetes mellitus_Homo sapiens_hsa049301.20838748
30RNA degradation_Homo sapiens_hsa030181.19931439
31Lysine degradation_Homo sapiens_hsa003101.19441557
32Cardiac muscle contraction_Homo sapiens_hsa042601.19155475
33Insulin secretion_Homo sapiens_hsa049111.14822204
34Salivary secretion_Homo sapiens_hsa049701.13348279
35mTOR signaling pathway_Homo sapiens_hsa041501.12869598
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12805472
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12747004
38Long-term depression_Homo sapiens_hsa047301.11179431
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10644416
40MicroRNAs in cancer_Homo sapiens_hsa052061.09071934
41Oocyte meiosis_Homo sapiens_hsa041141.08903423
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08733511
43Graft-versus-host disease_Homo sapiens_hsa053321.08041803
44Glutamatergic synapse_Homo sapiens_hsa047241.06794513
45Base excision repair_Homo sapiens_hsa034101.05810811
46GnRH signaling pathway_Homo sapiens_hsa049121.04636865
47Oxytocin signaling pathway_Homo sapiens_hsa049211.04115863
48Propanoate metabolism_Homo sapiens_hsa006401.03678409
49Allograft rejection_Homo sapiens_hsa053301.03646802
50Mismatch repair_Homo sapiens_hsa034301.02701474
51Homologous recombination_Homo sapiens_hsa034401.02235303
52Autoimmune thyroid disease_Homo sapiens_hsa053201.02075009
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00530639
54Circadian entrainment_Homo sapiens_hsa047130.99208626
55Selenocompound metabolism_Homo sapiens_hsa004500.98891398
56Pyrimidine metabolism_Homo sapiens_hsa002400.97796042
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97540206
58Olfactory transduction_Homo sapiens_hsa047400.97401793
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97335605
60Morphine addiction_Homo sapiens_hsa050320.97257897
61Gastric acid secretion_Homo sapiens_hsa049710.97212398
62B cell receptor signaling pathway_Homo sapiens_hsa046620.95107846
63Estrogen signaling pathway_Homo sapiens_hsa049150.94762314
64Phototransduction_Homo sapiens_hsa047440.93974571
65Proteasome_Homo sapiens_hsa030500.93741728
66Glioma_Homo sapiens_hsa052140.93264194
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92954987
68T cell receptor signaling pathway_Homo sapiens_hsa046600.91935039
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.91922272
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.90864181
71Dopaminergic synapse_Homo sapiens_hsa047280.90337427
72Non-small cell lung cancer_Homo sapiens_hsa052230.90194576
73cAMP signaling pathway_Homo sapiens_hsa040240.90154118
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89609089
75Herpes simplex infection_Homo sapiens_hsa051680.88739420
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87495559
77Chronic myeloid leukemia_Homo sapiens_hsa052200.86798717
78FoxO signaling pathway_Homo sapiens_hsa040680.85363678
79Prostate cancer_Homo sapiens_hsa052150.85333735
80Pancreatic secretion_Homo sapiens_hsa049720.85136221
81MAPK signaling pathway_Homo sapiens_hsa040100.85038073
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84771470
83Wnt signaling pathway_Homo sapiens_hsa043100.84751020
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84708983
85Platelet activation_Homo sapiens_hsa046110.84563534
86p53 signaling pathway_Homo sapiens_hsa041150.84271325
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83612080
88Glucagon signaling pathway_Homo sapiens_hsa049220.83355655
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83025088
90Adherens junction_Homo sapiens_hsa045200.82664094
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82563997
92Calcium signaling pathway_Homo sapiens_hsa040200.82380562
93Prolactin signaling pathway_Homo sapiens_hsa049170.82336352
94Measles_Homo sapiens_hsa051620.81003345
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80179948
96Choline metabolism in cancer_Homo sapiens_hsa052310.79846774
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.79638688
98Viral carcinogenesis_Homo sapiens_hsa052030.79029433
99Primary immunodeficiency_Homo sapiens_hsa053400.78717525
100beta-Alanine metabolism_Homo sapiens_hsa004100.77919150
101ErbB signaling pathway_Homo sapiens_hsa040120.75375285
102Fatty acid degradation_Homo sapiens_hsa000710.75273872
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74716221
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73694166
105Serotonergic synapse_Homo sapiens_hsa047260.72635449
106Purine metabolism_Homo sapiens_hsa002300.71214780
107Tryptophan metabolism_Homo sapiens_hsa003800.71128902
108HTLV-I infection_Homo sapiens_hsa051660.70717522
109Rap1 signaling pathway_Homo sapiens_hsa040150.70669641
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70239643
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70136565
112Chemokine signaling pathway_Homo sapiens_hsa040620.70056068
113Alzheimers disease_Homo sapiens_hsa050100.69923057
114Cholinergic synapse_Homo sapiens_hsa047250.68931079
115Leishmaniasis_Homo sapiens_hsa051400.67927358
116Circadian rhythm_Homo sapiens_hsa047100.67524186
117Taste transduction_Homo sapiens_hsa047420.67267205
118Linoleic acid metabolism_Homo sapiens_hsa005910.67237406
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.67021974
120African trypanosomiasis_Homo sapiens_hsa051430.66894914
121Small cell lung cancer_Homo sapiens_hsa052220.65515126
122GABAergic synapse_Homo sapiens_hsa047270.65383806
123Thyroid hormone synthesis_Homo sapiens_hsa049180.64782021
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63127485
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.62605604
126Renal cell carcinoma_Homo sapiens_hsa052110.62365418
127Cocaine addiction_Homo sapiens_hsa050300.62030872
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61061979
129Type I diabetes mellitus_Homo sapiens_hsa049400.60887401
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60217539
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.60028989
132Proteoglycans in cancer_Homo sapiens_hsa052050.59248092
133Antigen processing and presentation_Homo sapiens_hsa046120.59193372
134Epstein-Barr virus infection_Homo sapiens_hsa051690.59118120
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58962041
136Pathways in cancer_Homo sapiens_hsa052000.58422048
137Colorectal cancer_Homo sapiens_hsa052100.58361036
138Caffeine metabolism_Homo sapiens_hsa002320.57963987
139Melanogenesis_Homo sapiens_hsa049160.57688955
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.57142799
141Osteoclast differentiation_Homo sapiens_hsa043800.56648932
142Systemic lupus erythematosus_Homo sapiens_hsa053220.54594229
143Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48713472
144Hepatitis B_Homo sapiens_hsa051610.48457615
145Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47160283
146Histidine metabolism_Homo sapiens_hsa003400.46865668
147Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43956771
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43520185
149alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43165731
150Influenza A_Homo sapiens_hsa051640.43144312
151Hematopoietic cell lineage_Homo sapiens_hsa046400.42437592
152Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39956077
153Acute myeloid leukemia_Homo sapiens_hsa052210.39485124
154Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36373758
155Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35115828
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34942296
157Thyroid cancer_Homo sapiens_hsa052160.32649875
158Pancreatic cancer_Homo sapiens_hsa052120.30887839
159Nitrogen metabolism_Homo sapiens_hsa009100.30457604
160Pyruvate metabolism_Homo sapiens_hsa006200.28693071
161Glycerolipid metabolism_Homo sapiens_hsa005610.27564955
162SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25935617

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