UPF3AP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.87241076
2establishment of protein localization to mitochondrial membrane (GO:0090151)6.21241400
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.85971144
4ATP synthesis coupled proton transport (GO:0015986)5.85971144
5sequestering of actin monomers (GO:0042989)5.79976362
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.90313075
7viral transcription (GO:0019083)4.82090360
8protein neddylation (GO:0045116)4.74494256
9translational termination (GO:0006415)4.74262047
10behavioral response to nicotine (GO:0035095)4.66555035
11respiratory electron transport chain (GO:0022904)4.60849433
12electron transport chain (GO:0022900)4.53730519
13sulfation (GO:0051923)4.09446949
14cotranslational protein targeting to membrane (GO:0006613)4.03190722
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.99172380
16protein targeting to ER (GO:0045047)3.98505287
17ribosomal small subunit assembly (GO:0000028)3.96430616
18chaperone-mediated protein transport (GO:0072321)3.92500611
19neuron cell-cell adhesion (GO:0007158)3.90822776
20maturation of SSU-rRNA (GO:0030490)3.88246775
21cell proliferation in forebrain (GO:0021846)3.87190405
22establishment of protein localization to endoplasmic reticulum (GO:0072599)3.80309749
23protein-cofactor linkage (GO:0018065)3.77947404
24translational elongation (GO:0006414)3.76580471
25neuron fate determination (GO:0048664)3.72970076
26protein complex biogenesis (GO:0070271)3.72811037
27inner mitochondrial membrane organization (GO:0007007)3.71471307
28protein localization to endoplasmic reticulum (GO:0070972)3.67779277
29presynaptic membrane assembly (GO:0097105)3.66621836
30ribosomal small subunit biogenesis (GO:0042274)3.63671526
31cellular protein complex disassembly (GO:0043624)3.59760769
32mitochondrial respiratory chain complex assembly (GO:0033108)3.46949641
33viral life cycle (GO:0019058)3.46557339
34gamma-aminobutyric acid transport (GO:0015812)3.44526235
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40999123
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.40999123
37NADH dehydrogenase complex assembly (GO:0010257)3.40999123
38presynaptic membrane organization (GO:0097090)3.38282751
39hydrogen ion transmembrane transport (GO:1902600)3.33714873
40regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.31044427
41ATP biosynthetic process (GO:0006754)3.19509461
42intracellular protein transmembrane import (GO:0044743)3.19048457
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.16837776
44regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.13490661
45proton transport (GO:0015992)3.11517563
46hydrogen transport (GO:0006818)3.06390935
47DNA deamination (GO:0045006)3.05834288
48water-soluble vitamin biosynthetic process (GO:0042364)3.05809508
49protein complex disassembly (GO:0043241)3.02932999
50postsynaptic membrane organization (GO:0001941)2.99454918
51transcription elongation from RNA polymerase III promoter (GO:0006385)2.97451469
52termination of RNA polymerase III transcription (GO:0006386)2.97451469
53vascular smooth muscle contraction (GO:0014829)2.95764147
54translational initiation (GO:0006413)2.95299694
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89608008
56purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.88130543
57macromolecular complex disassembly (GO:0032984)2.83829533
58purine nucleoside triphosphate biosynthetic process (GO:0009145)2.83484165
59negative regulation of transcription regulatory region DNA binding (GO:2000678)2.76649367
60kidney morphogenesis (GO:0060993)2.75906073
61response to pheromone (GO:0019236)2.74861590
62artery smooth muscle contraction (GO:0014824)2.73217321
63DNA damage response, detection of DNA damage (GO:0042769)2.73044058
64negative regulation of response to food (GO:0032096)2.71964889
65negative regulation of appetite (GO:0032099)2.71964889
66forebrain neuron differentiation (GO:0021879)2.70801596
67regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.70449156
68pyrimidine nucleobase catabolic process (GO:0006208)2.65183036
69chromatin remodeling at centromere (GO:0031055)2.62847766
70regulation of mesoderm development (GO:2000380)2.62833922
71intracellular protein transmembrane transport (GO:0065002)2.62612103
72translation (GO:0006412)2.62115540
73positive regulation of protein homodimerization activity (GO:0090073)2.60433178
74pituitary gland development (GO:0021983)2.60160834
75protein targeting to membrane (GO:0006612)2.58313257
76exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.57967535
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.57251171
78synaptic transmission, cholinergic (GO:0007271)2.57153576
79resolution of meiotic recombination intermediates (GO:0000712)2.56141343
80nonmotile primary cilium assembly (GO:0035058)2.56074567
81otic vesicle formation (GO:0030916)2.56046902
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.54982404
83ribosomal large subunit biogenesis (GO:0042273)2.53282712
84somite development (GO:0061053)2.51503802
85neuronal stem cell maintenance (GO:0097150)2.48247980
86vocalization behavior (GO:0071625)2.46434989
87transmission of nerve impulse (GO:0019226)2.46153883
88regulation of action potential (GO:0098900)2.45833371
89tongue development (GO:0043586)2.45434441
90respiratory chain complex IV assembly (GO:0008535)2.44788041
91membrane repolarization (GO:0086009)2.43195881
92cytochrome complex assembly (GO:0017004)2.41895136
93mechanosensory behavior (GO:0007638)2.41423307
94protein transmembrane transport (GO:0071806)2.40680509
95negative regulation of heart rate (GO:0010459)2.39531786
96axonemal dynein complex assembly (GO:0070286)2.37747024
97protein localization to synapse (GO:0035418)2.36946690
98ribonucleoside triphosphate biosynthetic process (GO:0009201)2.36899870
99cellular component biogenesis (GO:0044085)2.35552310
100neuronal action potential (GO:0019228)2.34763210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.08343974
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.55627000
3VDR_22108803_ChIP-Seq_LS180_Human2.96305008
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.81300974
5ZNF274_21170338_ChIP-Seq_K562_Hela2.80502108
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.79739978
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.57410022
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55637448
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.52264783
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40867492
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.37692968
12IGF1R_20145208_ChIP-Seq_DFB_Human2.25916802
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19229722
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15888044
15CBX2_27304074_Chip-Seq_ESCs_Mouse2.09704237
16POU5F1_16153702_ChIP-ChIP_HESCs_Human2.02304434
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01237436
18EWS_26573619_Chip-Seq_HEK293_Human2.00912302
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00561040
20MYC_18940864_ChIP-ChIP_HL60_Human1.94201839
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89049670
22FUS_26573619_Chip-Seq_HEK293_Human1.86239880
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84993418
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.82420174
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77230098
26IRF1_19129219_ChIP-ChIP_H3396_Human1.74102242
27REST_21632747_ChIP-Seq_MESCs_Mouse1.73359558
28RNF2_27304074_Chip-Seq_NSC_Mouse1.70434411
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69506802
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.65540222
31P300_19829295_ChIP-Seq_ESCs_Human1.62118968
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61858897
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58027453
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.53189429
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49024216
36HTT_18923047_ChIP-ChIP_STHdh_Human1.48953096
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43962225
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43770571
39GBX2_23144817_ChIP-Seq_PC3_Human1.43411203
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41765104
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40639227
42ER_23166858_ChIP-Seq_MCF-7_Human1.36601543
43SOX2_16153702_ChIP-ChIP_HESCs_Human1.35270636
44TAF15_26573619_Chip-Seq_HEK293_Human1.35183704
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34905096
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34102207
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32765712
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.32352060
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32179719
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32179719
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.30960032
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26695836
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.25355020
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.25155720
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.24792101
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24096285
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23454871
58ELK1_19687146_ChIP-ChIP_HELA_Human1.22710719
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22613897
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22496084
61BCAT_22108803_ChIP-Seq_LS180_Human1.21538806
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21061156
63TP53_22573176_ChIP-Seq_HFKS_Human1.20822246
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20086625
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19265087
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17744703
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.17495069
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15603846
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.15085902
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.13159077
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12784740
72CBP_20019798_ChIP-Seq_JUKART_Human1.11753098
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11753098
74VDR_23849224_ChIP-Seq_CD4+_Human1.09994798
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08203576
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05209260
77RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05209260
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03445420
79AR_25329375_ChIP-Seq_VCAP_Human1.02972119
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01855924
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.01855924
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01597217
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.00521555
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00410325
85NCOR_22424771_ChIP-Seq_293T_Human1.00071051
86FOXP3_21729870_ChIP-Seq_TREG_Human0.99439281
87NANOG_16153702_ChIP-ChIP_HESCs_Human0.97419995
88TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96385855
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96280891
90TCF4_22108803_ChIP-Seq_LS180_Human0.96186813
91SMAD4_21799915_ChIP-Seq_A2780_Human0.95269336
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95194981
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94884416
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93776508
95NANOG_19829295_ChIP-Seq_ESCs_Human0.92972668
96SOX2_19829295_ChIP-Seq_ESCs_Human0.92972668
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90417389
98YY1_21170310_ChIP-Seq_MESCs_Mouse0.90219678
99TTF2_22483619_ChIP-Seq_HELA_Human0.89385904
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.88619356

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.45086201
2MP0006292_abnormal_olfactory_placode4.43638448
3MP0009379_abnormal_foot_pigmentation3.80440447
4MP0008877_abnormal_DNA_methylation2.57515841
5MP0002653_abnormal_ependyma_morphology2.38677042
6MP0001485_abnormal_pinna_reflex2.21953921
7MP0002277_abnormal_respiratory_mucosa2.19672164
8MP0003122_maternal_imprinting2.11642105
9MP0001293_anophthalmia2.11503140
10MP0010386_abnormal_urinary_bladder2.07198092
11MP0002638_abnormal_pupillary_reflex2.06221205
12MP0010030_abnormal_orbit_morphology2.04685741
13MP0000631_abnormal_neuroendocrine_gland1.97456577
14MP0004133_heterotaxia1.97345602
15MP0004142_abnormal_muscle_tone1.93212083
16MP0009046_muscle_twitch1.90886065
17MP0003787_abnormal_imprinting1.89497723
18MP0001188_hyperpigmentation1.85377954
19MP0002938_white_spotting1.84360721
20MP0009745_abnormal_behavioral_response1.82109705
21MP0004885_abnormal_endolymph1.81824959
22MP0000778_abnormal_nervous_system1.79494366
23MP0003121_genomic_imprinting1.65839678
24MP0005551_abnormal_eye_electrophysiolog1.65494813
25MP0002102_abnormal_ear_morphology1.61747044
26MP0002272_abnormal_nervous_system1.59996597
27MP0001968_abnormal_touch/_nociception1.59636763
28MP0003880_abnormal_central_pattern1.56557686
29MP0008789_abnormal_olfactory_epithelium1.53510210
30MP0005084_abnormal_gallbladder_morpholo1.50793141
31MP0002064_seizures1.47050750
32MP0001970_abnormal_pain_threshold1.42973737
33MP0002733_abnormal_thermal_nociception1.41378086
34MP0005377_hearing/vestibular/ear_phenot1.40774805
35MP0003878_abnormal_ear_physiology1.40774805
36MP0006072_abnormal_retinal_apoptosis1.39672673
37MP0002572_abnormal_emotion/affect_behav1.38461630
38MP0003283_abnormal_digestive_organ1.35473287
39MP0002736_abnormal_nociception_after1.33990484
40MP0004742_abnormal_vestibular_system1.32682522
41MP0005174_abnormal_tail_pigmentation1.32117260
42MP0005423_abnormal_somatic_nervous1.29734657
43MP0002837_dystrophic_cardiac_calcinosis1.29350601
44MP0002734_abnormal_mechanical_nocicepti1.28795709
45MP0002234_abnormal_pharynx_morphology1.28586694
46MP0000026_abnormal_inner_ear1.27110882
47MP0005645_abnormal_hypothalamus_physiol1.25514649
48MP0006276_abnormal_autonomic_nervous1.24897420
49MP0001529_abnormal_vocalization1.24382113
50MP0001286_abnormal_eye_development1.23048604
51MP0003635_abnormal_synaptic_transmissio1.20085925
52MP0003938_abnormal_ear_development1.18942940
53MP0005195_abnormal_posterior_eye1.18182163
54MP0005499_abnormal_olfactory_system1.18172966
55MP0005394_taste/olfaction_phenotype1.18172966
56MP0008995_early_reproductive_senescence1.17853940
57MP0000955_abnormal_spinal_cord1.17327421
58MP0002557_abnormal_social/conspecific_i1.16612854
59MP0001486_abnormal_startle_reflex1.12760283
60MP0001984_abnormal_olfaction1.12667400
61MP0002752_abnormal_somatic_nervous1.10302808
62MP0000049_abnormal_middle_ear1.08797889
63MP0001905_abnormal_dopamine_level1.08289771
64MP0004043_abnormal_pH_regulation1.08031684
65MP0005646_abnormal_pituitary_gland1.07476634
66MP0002063_abnormal_learning/memory/cond1.07155015
67MP0002184_abnormal_innervation1.05735556
68MP0003890_abnormal_embryonic-extraembry1.05133117
69MP0002067_abnormal_sensory_capabilities1.03981789
70MP0002095_abnormal_skin_pigmentation1.03296351
71MP0003195_calcinosis0.99582746
72MP0004859_abnormal_synaptic_plasticity0.95770650
73MP0005253_abnormal_eye_physiology0.93784555
74MP0003119_abnormal_digestive_system0.93502186
75MP0008872_abnormal_physiological_respon0.90838338
76MP0003011_delayed_dark_adaptation0.90824264
77MP0002735_abnormal_chemical_nociception0.89628523
78MP0002160_abnormal_reproductive_system0.88732217
79MP0000569_abnormal_digit_pigmentation0.88295822
80MP0002882_abnormal_neuron_morphology0.87513841
81MP0005391_vision/eye_phenotype0.86010645
82MP0005171_absent_coat_pigmentation0.85113204
83MP0002751_abnormal_autonomic_nervous0.84968716
84MP0005386_behavior/neurological_phenoty0.84891218
85MP0004924_abnormal_behavior0.84891218
86MP0002697_abnormal_eye_size0.83786194
87MP0002822_catalepsy0.83764149
88MP0001963_abnormal_hearing_physiology0.82983386
89MP0004145_abnormal_muscle_electrophysio0.82765169
90MP0001440_abnormal_grooming_behavior0.82669710
91MP0005389_reproductive_system_phenotype0.81231322
92MP0002210_abnormal_sex_determination0.80941829
93MP0002233_abnormal_nose_morphology0.80455837
94MP0002909_abnormal_adrenal_gland0.79548341
95MP0002152_abnormal_brain_morphology0.79440261
96MP0003861_abnormal_nervous_system0.76833216
97MP0003755_abnormal_palate_morphology0.76186730
98MP0004270_analgesia0.75550264
99MP0002282_abnormal_trachea_morphology0.75491548
100MP0003698_abnormal_male_reproductive0.75248552

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)5.02707576
2Reticulocytopenia (HP:0001896)4.22192370
3Acute necrotizing encephalopathy (HP:0006965)4.04922290
4Abnormal mitochondria in muscle tissue (HP:0008316)3.63810715
5Acute encephalopathy (HP:0006846)3.49025517
6Abnormal number of erythroid precursors (HP:0012131)3.46055911
7Progressive macrocephaly (HP:0004481)3.45995698
8Abnormality of cells of the erythroid lineage (HP:0012130)3.43355597
9Mitochondrial inheritance (HP:0001427)3.37363543
10Rib fusion (HP:0000902)3.34614821
11Macrocytic anemia (HP:0001972)3.30424290
12Pancreatic fibrosis (HP:0100732)3.26007282
13Maternal diabetes (HP:0009800)3.22819368
14Congenital, generalized hypertrichosis (HP:0004540)3.18588954
15Increased hepatocellular lipid droplets (HP:0006565)3.16732361
16Progressive cerebellar ataxia (HP:0002073)3.13885989
17True hermaphroditism (HP:0010459)3.13870141
18Abnormality of midbrain morphology (HP:0002418)3.08104701
19Molar tooth sign on MRI (HP:0002419)3.08104701
20Optic nerve hypoplasia (HP:0000609)3.03780555
21Absent septum pellucidum (HP:0001331)2.97832450
22Lipid accumulation in hepatocytes (HP:0006561)2.96227477
23Pancreatic cysts (HP:0001737)2.94816532
24Sclerocornea (HP:0000647)2.92875373
25Esophageal atresia (HP:0002032)2.83039145
26Increased CSF lactate (HP:0002490)2.78297774
27Optic disc pallor (HP:0000543)2.75882335
28Anophthalmia (HP:0000528)2.74529376
29Renal Fanconi syndrome (HP:0001994)2.71390151
30Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.68851033
31Abnormality of the labia minora (HP:0012880)2.67243138
32Pendular nystagmus (HP:0012043)2.63892565
33Congenital stationary night blindness (HP:0007642)2.53991292
34Abnormal number of incisors (HP:0011064)2.53802687
35Myokymia (HP:0002411)2.52978526
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.51365281
37Pallor (HP:0000980)2.49509360
38Abnormality of renal resorption (HP:0011038)2.47488002
39Nephronophthisis (HP:0000090)2.46734476
40Abnormal rod and cone electroretinograms (HP:0008323)2.44233425
41Methylmalonic acidemia (HP:0002912)2.43100339
42Abnormality of the septum pellucidum (HP:0007375)2.41936944
43Methylmalonic aciduria (HP:0012120)2.40687961
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40125762
45Gastrointestinal atresia (HP:0002589)2.39075092
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.38289473
47Medial flaring of the eyebrow (HP:0010747)2.32072240
48Cerebral edema (HP:0002181)2.28875430
493-Methylglutaconic aciduria (HP:0003535)2.27230064
50Anencephaly (HP:0002323)2.24423815
51Chronic hepatic failure (HP:0100626)2.21218848
52Abolished electroretinogram (ERG) (HP:0000550)2.15191738
53Abnormal respiratory motile cilium physiology (HP:0012261)2.14040276
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11743588
55Abnormal ciliary motility (HP:0012262)2.03763128
56Abnormality of urine glucose concentration (HP:0011016)2.01960124
57Glycosuria (HP:0003076)2.01960124
58Hyperphosphaturia (HP:0003109)2.01913937
59Exertional dyspnea (HP:0002875)2.01762615
60Leukodystrophy (HP:0002415)2.01440213
61Abnormality of alanine metabolism (HP:0010916)2.00457840
62Hyperalaninemia (HP:0003348)2.00457840
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00457840
64Chronic bronchitis (HP:0004469)1.99609837
65Gait imbalance (HP:0002141)1.98787937
66Male pseudohermaphroditism (HP:0000037)1.98024246
67Agitation (HP:0000713)1.96509599
68Hepatocellular necrosis (HP:0001404)1.96407703
69Colon cancer (HP:0003003)1.96002093
70Retinal dysplasia (HP:0007973)1.92375964
71Attenuation of retinal blood vessels (HP:0007843)1.90677567
72Increased intramyocellular lipid droplets (HP:0012240)1.89334798
73Hepatic necrosis (HP:0002605)1.87844205
74Lissencephaly (HP:0001339)1.86012466
75Median cleft lip (HP:0000161)1.85314116
76Hyperventilation (HP:0002883)1.84245360
77Abnormality of the renal medulla (HP:0100957)1.81401055
78Abnormality of DNA repair (HP:0003254)1.79272981
79Decreased central vision (HP:0007663)1.76212247
80Broad-based gait (HP:0002136)1.76112801
81Increased serum lactate (HP:0002151)1.75375468
82Cystic liver disease (HP:0006706)1.75328379
83Congenital primary aphakia (HP:0007707)1.74331495
84Growth hormone deficiency (HP:0000824)1.74185415
85Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.73806131
86Hypomagnesemia (HP:0002917)1.73288316
87Nephrogenic diabetes insipidus (HP:0009806)1.73126343
88Genital tract atresia (HP:0001827)1.71942656
89Neuroendocrine neoplasm (HP:0100634)1.69430204
90Vaginal atresia (HP:0000148)1.69033377
91Large for gestational age (HP:0001520)1.67490271
92Absent/shortened dynein arms (HP:0200106)1.67327376
93Dynein arm defect of respiratory motile cilia (HP:0012255)1.67327376
94Abnormal urine phosphate concentration (HP:0012599)1.67248313
95Abnormality of magnesium homeostasis (HP:0004921)1.66017982
96Type II lissencephaly (HP:0007260)1.65893082
97Epileptic encephalopathy (HP:0200134)1.65790577
98Bony spicule pigmentary retinopathy (HP:0007737)1.64720297
99Generalized aminoaciduria (HP:0002909)1.64559543
100Aplastic anemia (HP:0001915)1.64178320

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK166.01967606
2PNCK4.17385007
3ZAK3.49205342
4CASK3.12883241
5WNK32.70232368
6MAPK152.55911747
7NUAK12.33124196
8WNK42.28719093
9VRK12.27218456
10WEE12.15955940
11TLK12.13802048
12CDC71.87093164
13VRK21.84407003
14DYRK21.81801954
15MARK11.79236784
16GRK11.69237093
17NTRK31.67159423
18ADRBK21.58931693
19MAP4K21.54351824
20MAPK131.51192138
21TNIK1.46020898
22TAF11.45987872
23BUB11.45973017
24MAP2K71.42939003
25PINK11.40164461
26NTRK21.39534776
27BMPR1B1.38407860
28DYRK31.23851191
29FRK1.23421008
30EPHB21.17585892
31KDR1.11288783
32MAP3K41.11039928
33PLK31.07606604
34PRKCG0.95847496
35INSRR0.94288769
36BRSK20.89899826
37PLK40.89188646
38TIE10.88654170
39RPS6KA40.83193400
40TSSK60.82308736
41PASK0.81857589
42EPHA40.81675713
43PAK30.79153994
44BCKDK0.77641362
45SIK20.77495728
46TYRO30.73449549
47STK390.72586690
48NEK20.70560392
49MAP3K110.69366666
50OXSR10.68865986
51ADRBK10.67522781
52MINK10.67140063
53LATS10.66998710
54STK240.65349580
55PLK10.64314323
56STK38L0.63193586
57PHKG20.62402488
58PHKG10.62402488
59STK30.62294563
60CDK30.61146927
61NME10.60619992
62AURKA0.58945530
63UHMK10.58062013
64CSNK1E0.57378002
65CDK80.56411792
66PIK3CA0.54458278
67GRK70.54208262
68TAOK30.53900548
69DYRK1A0.52765371
70CHEK20.51833231
71DMPK0.49056883
72PRKACA0.45401306
73BRSK10.45060966
74MAP2K40.44689310
75RPS6KA50.44677790
76MAP3K100.43075019
77ATR0.42246596
78PRKCQ0.41774615
79PRKCE0.40921525
80TGFBR10.40516650
81PKN10.39780591
82SGK2230.39122598
83SGK4940.39122598
84DAPK20.39022856
85PLK20.38634929
86PRKG10.37711506
87MST40.37579780
88CAMK2A0.36853799
89TEC0.36533808
90LIMK10.34911101
91MKNK20.34789411
92TXK0.34475883
93PIM10.34019584
94CSNK1A10.33507115
95CSNK2A10.32460331
96CAMK10.31758849
97DAPK30.31011648
98SGK10.30678929
99CSNK2A20.29946701
100PRKDC0.27417589

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.86783190
2Ribosome_Homo sapiens_hsa030104.64062176
3Parkinsons disease_Homo sapiens_hsa050124.04126265
4Cardiac muscle contraction_Homo sapiens_hsa042602.92161233
5Alzheimers disease_Homo sapiens_hsa050102.84611150
6Protein export_Homo sapiens_hsa030602.82747348
7Huntingtons disease_Homo sapiens_hsa050162.80382698
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.53338576
9Nicotine addiction_Homo sapiens_hsa050332.33959192
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26030841
11RNA polymerase_Homo sapiens_hsa030202.24902060
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.10214845
13Proteasome_Homo sapiens_hsa030501.95986948
14Homologous recombination_Homo sapiens_hsa034401.77411306
15Phototransduction_Homo sapiens_hsa047441.75739720
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74625624
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73508869
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59647303
19Basal transcription factors_Homo sapiens_hsa030221.49165762
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43903715
21Mismatch repair_Homo sapiens_hsa034301.39625895
22Taste transduction_Homo sapiens_hsa047421.38991156
23Nitrogen metabolism_Homo sapiens_hsa009101.34623411
24Butanoate metabolism_Homo sapiens_hsa006501.30023326
25Spliceosome_Homo sapiens_hsa030401.27779703
26Fanconi anemia pathway_Homo sapiens_hsa034601.27349305
27Sulfur relay system_Homo sapiens_hsa041221.20865668
28Nucleotide excision repair_Homo sapiens_hsa034201.20750858
29RNA degradation_Homo sapiens_hsa030181.16870187
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12999472
31Insulin secretion_Homo sapiens_hsa049111.12676416
32Tryptophan metabolism_Homo sapiens_hsa003801.09583829
33Linoleic acid metabolism_Homo sapiens_hsa005911.08180185
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.05634849
35Vitamin digestion and absorption_Homo sapiens_hsa049771.04292967
36Cocaine addiction_Homo sapiens_hsa050301.00932934
37GABAergic synapse_Homo sapiens_hsa047270.97485207
38Folate biosynthesis_Homo sapiens_hsa007900.95787747
39Steroid biosynthesis_Homo sapiens_hsa001000.90847743
40Collecting duct acid secretion_Homo sapiens_hsa049660.89679325
41Hedgehog signaling pathway_Homo sapiens_hsa043400.89469339
42Basal cell carcinoma_Homo sapiens_hsa052170.89102121
43Ether lipid metabolism_Homo sapiens_hsa005650.84494304
44Olfactory transduction_Homo sapiens_hsa047400.84252173
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79973890
46Morphine addiction_Homo sapiens_hsa050320.78110483
47Propanoate metabolism_Homo sapiens_hsa006400.78023543
48Chemical carcinogenesis_Homo sapiens_hsa052040.77582558
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75417752
50Purine metabolism_Homo sapiens_hsa002300.73667617
51Glutamatergic synapse_Homo sapiens_hsa047240.70454244
52Circadian entrainment_Homo sapiens_hsa047130.69940594
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69875377
54Caffeine metabolism_Homo sapiens_hsa002320.69604668
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68841255
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67872142
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67387728
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66871052
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63798354
60Pyrimidine metabolism_Homo sapiens_hsa002400.63027164
61Peroxisome_Homo sapiens_hsa041460.61766277
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60965987
63DNA replication_Homo sapiens_hsa030300.60021116
64Serotonergic synapse_Homo sapiens_hsa047260.59850751
65Metabolic pathways_Homo sapiens_hsa011000.58597806
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57285912
67Amphetamine addiction_Homo sapiens_hsa050310.56087942
68Retinol metabolism_Homo sapiens_hsa008300.55744019
69Hippo signaling pathway_Homo sapiens_hsa043900.54513935
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54000307
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52721027
72Synaptic vesicle cycle_Homo sapiens_hsa047210.50448177
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50427134
74Selenocompound metabolism_Homo sapiens_hsa004500.48312105
75One carbon pool by folate_Homo sapiens_hsa006700.45283459
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.43057480
77beta-Alanine metabolism_Homo sapiens_hsa004100.42389669
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42372471
79Pyruvate metabolism_Homo sapiens_hsa006200.41115790
80Dopaminergic synapse_Homo sapiens_hsa047280.40442367
81Fatty acid degradation_Homo sapiens_hsa000710.40345876
82Fat digestion and absorption_Homo sapiens_hsa049750.39642283
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38250864
84RNA transport_Homo sapiens_hsa030130.38155839
85Base excision repair_Homo sapiens_hsa034100.37548876
86Wnt signaling pathway_Homo sapiens_hsa043100.37133029
87Melanogenesis_Homo sapiens_hsa049160.36930764
88Cholinergic synapse_Homo sapiens_hsa047250.36375659
89cAMP signaling pathway_Homo sapiens_hsa040240.34815165
90Calcium signaling pathway_Homo sapiens_hsa040200.33927628
91Primary immunodeficiency_Homo sapiens_hsa053400.33803957
92Salivary secretion_Homo sapiens_hsa049700.31725667
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31411968
94Axon guidance_Homo sapiens_hsa043600.31231730
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.30241421
96Arachidonic acid metabolism_Homo sapiens_hsa005900.28078949
97Mineral absorption_Homo sapiens_hsa049780.27294946
98Gap junction_Homo sapiens_hsa045400.26604841
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25517942
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22610714

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