Rank | Gene Set | Z-score |
---|---|---|
1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.87241076 |
2 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 6.21241400 |
3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.85971144 |
4 | ATP synthesis coupled proton transport (GO:0015986) | 5.85971144 |
5 | sequestering of actin monomers (GO:0042989) | 5.79976362 |
6 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.90313075 |
7 | viral transcription (GO:0019083) | 4.82090360 |
8 | protein neddylation (GO:0045116) | 4.74494256 |
9 | translational termination (GO:0006415) | 4.74262047 |
10 | behavioral response to nicotine (GO:0035095) | 4.66555035 |
11 | respiratory electron transport chain (GO:0022904) | 4.60849433 |
12 | electron transport chain (GO:0022900) | 4.53730519 |
13 | sulfation (GO:0051923) | 4.09446949 |
14 | cotranslational protein targeting to membrane (GO:0006613) | 4.03190722 |
15 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.99172380 |
16 | protein targeting to ER (GO:0045047) | 3.98505287 |
17 | ribosomal small subunit assembly (GO:0000028) | 3.96430616 |
18 | chaperone-mediated protein transport (GO:0072321) | 3.92500611 |
19 | neuron cell-cell adhesion (GO:0007158) | 3.90822776 |
20 | maturation of SSU-rRNA (GO:0030490) | 3.88246775 |
21 | cell proliferation in forebrain (GO:0021846) | 3.87190405 |
22 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.80309749 |
23 | protein-cofactor linkage (GO:0018065) | 3.77947404 |
24 | translational elongation (GO:0006414) | 3.76580471 |
25 | neuron fate determination (GO:0048664) | 3.72970076 |
26 | protein complex biogenesis (GO:0070271) | 3.72811037 |
27 | inner mitochondrial membrane organization (GO:0007007) | 3.71471307 |
28 | protein localization to endoplasmic reticulum (GO:0070972) | 3.67779277 |
29 | presynaptic membrane assembly (GO:0097105) | 3.66621836 |
30 | ribosomal small subunit biogenesis (GO:0042274) | 3.63671526 |
31 | cellular protein complex disassembly (GO:0043624) | 3.59760769 |
32 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.46949641 |
33 | viral life cycle (GO:0019058) | 3.46557339 |
34 | gamma-aminobutyric acid transport (GO:0015812) | 3.44526235 |
35 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.40999123 |
36 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.40999123 |
37 | NADH dehydrogenase complex assembly (GO:0010257) | 3.40999123 |
38 | presynaptic membrane organization (GO:0097090) | 3.38282751 |
39 | hydrogen ion transmembrane transport (GO:1902600) | 3.33714873 |
40 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.31044427 |
41 | ATP biosynthetic process (GO:0006754) | 3.19509461 |
42 | intracellular protein transmembrane import (GO:0044743) | 3.19048457 |
43 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.16837776 |
44 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.13490661 |
45 | proton transport (GO:0015992) | 3.11517563 |
46 | hydrogen transport (GO:0006818) | 3.06390935 |
47 | DNA deamination (GO:0045006) | 3.05834288 |
48 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.05809508 |
49 | protein complex disassembly (GO:0043241) | 3.02932999 |
50 | postsynaptic membrane organization (GO:0001941) | 2.99454918 |
51 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.97451469 |
52 | termination of RNA polymerase III transcription (GO:0006386) | 2.97451469 |
53 | vascular smooth muscle contraction (GO:0014829) | 2.95764147 |
54 | translational initiation (GO:0006413) | 2.95299694 |
55 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 2.89608008 |
56 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.88130543 |
57 | macromolecular complex disassembly (GO:0032984) | 2.83829533 |
58 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.83484165 |
59 | negative regulation of transcription regulatory region DNA binding (GO:2000678) | 2.76649367 |
60 | kidney morphogenesis (GO:0060993) | 2.75906073 |
61 | response to pheromone (GO:0019236) | 2.74861590 |
62 | artery smooth muscle contraction (GO:0014824) | 2.73217321 |
63 | DNA damage response, detection of DNA damage (GO:0042769) | 2.73044058 |
64 | negative regulation of response to food (GO:0032096) | 2.71964889 |
65 | negative regulation of appetite (GO:0032099) | 2.71964889 |
66 | forebrain neuron differentiation (GO:0021879) | 2.70801596 |
67 | regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095) | 2.70449156 |
68 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.65183036 |
69 | chromatin remodeling at centromere (GO:0031055) | 2.62847766 |
70 | regulation of mesoderm development (GO:2000380) | 2.62833922 |
71 | intracellular protein transmembrane transport (GO:0065002) | 2.62612103 |
72 | translation (GO:0006412) | 2.62115540 |
73 | positive regulation of protein homodimerization activity (GO:0090073) | 2.60433178 |
74 | pituitary gland development (GO:0021983) | 2.60160834 |
75 | protein targeting to membrane (GO:0006612) | 2.58313257 |
76 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.57967535 |
77 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.57251171 |
78 | synaptic transmission, cholinergic (GO:0007271) | 2.57153576 |
79 | resolution of meiotic recombination intermediates (GO:0000712) | 2.56141343 |
80 | nonmotile primary cilium assembly (GO:0035058) | 2.56074567 |
81 | otic vesicle formation (GO:0030916) | 2.56046902 |
82 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.54982404 |
83 | ribosomal large subunit biogenesis (GO:0042273) | 2.53282712 |
84 | somite development (GO:0061053) | 2.51503802 |
85 | neuronal stem cell maintenance (GO:0097150) | 2.48247980 |
86 | vocalization behavior (GO:0071625) | 2.46434989 |
87 | transmission of nerve impulse (GO:0019226) | 2.46153883 |
88 | regulation of action potential (GO:0098900) | 2.45833371 |
89 | tongue development (GO:0043586) | 2.45434441 |
90 | respiratory chain complex IV assembly (GO:0008535) | 2.44788041 |
91 | membrane repolarization (GO:0086009) | 2.43195881 |
92 | cytochrome complex assembly (GO:0017004) | 2.41895136 |
93 | mechanosensory behavior (GO:0007638) | 2.41423307 |
94 | protein transmembrane transport (GO:0071806) | 2.40680509 |
95 | negative regulation of heart rate (GO:0010459) | 2.39531786 |
96 | axonemal dynein complex assembly (GO:0070286) | 2.37747024 |
97 | protein localization to synapse (GO:0035418) | 2.36946690 |
98 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.36899870 |
99 | cellular component biogenesis (GO:0044085) | 2.35552310 |
100 | neuronal action potential (GO:0019228) | 2.34763210 |
Rank | Gene Set | Z-score |
---|---|---|
1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.08343974 |
2 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 3.55627000 |
3 | VDR_22108803_ChIP-Seq_LS180_Human | 2.96305008 |
4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.81300974 |
5 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.80502108 |
6 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.79739978 |
7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.57410022 |
8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.55637448 |
9 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.52264783 |
10 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.40867492 |
11 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.37692968 |
12 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.25916802 |
13 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.19229722 |
14 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.15888044 |
15 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 2.09704237 |
16 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 2.02304434 |
17 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 2.01237436 |
18 | EWS_26573619_Chip-Seq_HEK293_Human | 2.00912302 |
19 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.00561040 |
20 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.94201839 |
21 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.89049670 |
22 | FUS_26573619_Chip-Seq_HEK293_Human | 1.86239880 |
23 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.84993418 |
24 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.82420174 |
25 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.77230098 |
26 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.74102242 |
27 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.73359558 |
28 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.70434411 |
29 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.69506802 |
30 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.65540222 |
31 | P300_19829295_ChIP-Seq_ESCs_Human | 1.62118968 |
32 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.61858897 |
33 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.58027453 |
34 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.53189429 |
35 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.49024216 |
36 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.48953096 |
37 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.43962225 |
38 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.43770571 |
39 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.43411203 |
40 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.41765104 |
41 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.40639227 |
42 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.36601543 |
43 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.35270636 |
44 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.35183704 |
45 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.34905096 |
46 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.34102207 |
47 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.32765712 |
48 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.32352060 |
49 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.32179719 |
50 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.32179719 |
51 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.30960032 |
52 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.26695836 |
53 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.25355020 |
54 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.25155720 |
55 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.24792101 |
56 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.24096285 |
57 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.23454871 |
58 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.22710719 |
59 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.22613897 |
60 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.22496084 |
61 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.21538806 |
62 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.21061156 |
63 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.20822246 |
64 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.20086625 |
65 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.19265087 |
66 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.17744703 |
67 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.17495069 |
68 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.15603846 |
69 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.15085902 |
70 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.13159077 |
71 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.12784740 |
72 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.11753098 |
73 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.11753098 |
74 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.09994798 |
75 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.08203576 |
76 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.05209260 |
77 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.05209260 |
78 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.03445420 |
79 | AR_25329375_ChIP-Seq_VCAP_Human | 1.02972119 |
80 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.01855924 |
81 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.01855924 |
82 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.01597217 |
83 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.00521555 |
84 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.00410325 |
85 | NCOR_22424771_ChIP-Seq_293T_Human | 1.00071051 |
86 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.99439281 |
87 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.97419995 |
88 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.96385855 |
89 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 0.96280891 |
90 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.96186813 |
91 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.95269336 |
92 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.95194981 |
93 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.94884416 |
94 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.93776508 |
95 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.92972668 |
96 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.92972668 |
97 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.90417389 |
98 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.90219678 |
99 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.89385904 |
100 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 0.88619356 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003136_yellow_coat_color | 5.45086201 |
2 | MP0006292_abnormal_olfactory_placode | 4.43638448 |
3 | MP0009379_abnormal_foot_pigmentation | 3.80440447 |
4 | MP0008877_abnormal_DNA_methylation | 2.57515841 |
5 | MP0002653_abnormal_ependyma_morphology | 2.38677042 |
6 | MP0001485_abnormal_pinna_reflex | 2.21953921 |
7 | MP0002277_abnormal_respiratory_mucosa | 2.19672164 |
8 | MP0003122_maternal_imprinting | 2.11642105 |
9 | MP0001293_anophthalmia | 2.11503140 |
10 | MP0010386_abnormal_urinary_bladder | 2.07198092 |
11 | MP0002638_abnormal_pupillary_reflex | 2.06221205 |
12 | MP0010030_abnormal_orbit_morphology | 2.04685741 |
13 | MP0000631_abnormal_neuroendocrine_gland | 1.97456577 |
14 | MP0004133_heterotaxia | 1.97345602 |
15 | MP0004142_abnormal_muscle_tone | 1.93212083 |
16 | MP0009046_muscle_twitch | 1.90886065 |
17 | MP0003787_abnormal_imprinting | 1.89497723 |
18 | MP0001188_hyperpigmentation | 1.85377954 |
19 | MP0002938_white_spotting | 1.84360721 |
20 | MP0009745_abnormal_behavioral_response | 1.82109705 |
21 | MP0004885_abnormal_endolymph | 1.81824959 |
22 | MP0000778_abnormal_nervous_system | 1.79494366 |
23 | MP0003121_genomic_imprinting | 1.65839678 |
24 | MP0005551_abnormal_eye_electrophysiolog | 1.65494813 |
25 | MP0002102_abnormal_ear_morphology | 1.61747044 |
26 | MP0002272_abnormal_nervous_system | 1.59996597 |
27 | MP0001968_abnormal_touch/_nociception | 1.59636763 |
28 | MP0003880_abnormal_central_pattern | 1.56557686 |
29 | MP0008789_abnormal_olfactory_epithelium | 1.53510210 |
30 | MP0005084_abnormal_gallbladder_morpholo | 1.50793141 |
31 | MP0002064_seizures | 1.47050750 |
32 | MP0001970_abnormal_pain_threshold | 1.42973737 |
33 | MP0002733_abnormal_thermal_nociception | 1.41378086 |
34 | MP0005377_hearing/vestibular/ear_phenot | 1.40774805 |
35 | MP0003878_abnormal_ear_physiology | 1.40774805 |
36 | MP0006072_abnormal_retinal_apoptosis | 1.39672673 |
37 | MP0002572_abnormal_emotion/affect_behav | 1.38461630 |
38 | MP0003283_abnormal_digestive_organ | 1.35473287 |
39 | MP0002736_abnormal_nociception_after | 1.33990484 |
40 | MP0004742_abnormal_vestibular_system | 1.32682522 |
41 | MP0005174_abnormal_tail_pigmentation | 1.32117260 |
42 | MP0005423_abnormal_somatic_nervous | 1.29734657 |
43 | MP0002837_dystrophic_cardiac_calcinosis | 1.29350601 |
44 | MP0002734_abnormal_mechanical_nocicepti | 1.28795709 |
45 | MP0002234_abnormal_pharynx_morphology | 1.28586694 |
46 | MP0000026_abnormal_inner_ear | 1.27110882 |
47 | MP0005645_abnormal_hypothalamus_physiol | 1.25514649 |
48 | MP0006276_abnormal_autonomic_nervous | 1.24897420 |
49 | MP0001529_abnormal_vocalization | 1.24382113 |
50 | MP0001286_abnormal_eye_development | 1.23048604 |
51 | MP0003635_abnormal_synaptic_transmissio | 1.20085925 |
52 | MP0003938_abnormal_ear_development | 1.18942940 |
53 | MP0005195_abnormal_posterior_eye | 1.18182163 |
54 | MP0005499_abnormal_olfactory_system | 1.18172966 |
55 | MP0005394_taste/olfaction_phenotype | 1.18172966 |
56 | MP0008995_early_reproductive_senescence | 1.17853940 |
57 | MP0000955_abnormal_spinal_cord | 1.17327421 |
58 | MP0002557_abnormal_social/conspecific_i | 1.16612854 |
59 | MP0001486_abnormal_startle_reflex | 1.12760283 |
60 | MP0001984_abnormal_olfaction | 1.12667400 |
61 | MP0002752_abnormal_somatic_nervous | 1.10302808 |
62 | MP0000049_abnormal_middle_ear | 1.08797889 |
63 | MP0001905_abnormal_dopamine_level | 1.08289771 |
64 | MP0004043_abnormal_pH_regulation | 1.08031684 |
65 | MP0005646_abnormal_pituitary_gland | 1.07476634 |
66 | MP0002063_abnormal_learning/memory/cond | 1.07155015 |
67 | MP0002184_abnormal_innervation | 1.05735556 |
68 | MP0003890_abnormal_embryonic-extraembry | 1.05133117 |
69 | MP0002067_abnormal_sensory_capabilities | 1.03981789 |
70 | MP0002095_abnormal_skin_pigmentation | 1.03296351 |
71 | MP0003195_calcinosis | 0.99582746 |
72 | MP0004859_abnormal_synaptic_plasticity | 0.95770650 |
73 | MP0005253_abnormal_eye_physiology | 0.93784555 |
74 | MP0003119_abnormal_digestive_system | 0.93502186 |
75 | MP0008872_abnormal_physiological_respon | 0.90838338 |
76 | MP0003011_delayed_dark_adaptation | 0.90824264 |
77 | MP0002735_abnormal_chemical_nociception | 0.89628523 |
78 | MP0002160_abnormal_reproductive_system | 0.88732217 |
79 | MP0000569_abnormal_digit_pigmentation | 0.88295822 |
80 | MP0002882_abnormal_neuron_morphology | 0.87513841 |
81 | MP0005391_vision/eye_phenotype | 0.86010645 |
82 | MP0005171_absent_coat_pigmentation | 0.85113204 |
83 | MP0002751_abnormal_autonomic_nervous | 0.84968716 |
84 | MP0005386_behavior/neurological_phenoty | 0.84891218 |
85 | MP0004924_abnormal_behavior | 0.84891218 |
86 | MP0002697_abnormal_eye_size | 0.83786194 |
87 | MP0002822_catalepsy | 0.83764149 |
88 | MP0001963_abnormal_hearing_physiology | 0.82983386 |
89 | MP0004145_abnormal_muscle_electrophysio | 0.82765169 |
90 | MP0001440_abnormal_grooming_behavior | 0.82669710 |
91 | MP0005389_reproductive_system_phenotype | 0.81231322 |
92 | MP0002210_abnormal_sex_determination | 0.80941829 |
93 | MP0002233_abnormal_nose_morphology | 0.80455837 |
94 | MP0002909_abnormal_adrenal_gland | 0.79548341 |
95 | MP0002152_abnormal_brain_morphology | 0.79440261 |
96 | MP0003861_abnormal_nervous_system | 0.76833216 |
97 | MP0003755_abnormal_palate_morphology | 0.76186730 |
98 | MP0004270_analgesia | 0.75550264 |
99 | MP0002282_abnormal_trachea_morphology | 0.75491548 |
100 | MP0003698_abnormal_male_reproductive | 0.75248552 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Septo-optic dysplasia (HP:0100842) | 5.02707576 |
2 | Reticulocytopenia (HP:0001896) | 4.22192370 |
3 | Acute necrotizing encephalopathy (HP:0006965) | 4.04922290 |
4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.63810715 |
5 | Acute encephalopathy (HP:0006846) | 3.49025517 |
6 | Abnormal number of erythroid precursors (HP:0012131) | 3.46055911 |
7 | Progressive macrocephaly (HP:0004481) | 3.45995698 |
8 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.43355597 |
9 | Mitochondrial inheritance (HP:0001427) | 3.37363543 |
10 | Rib fusion (HP:0000902) | 3.34614821 |
11 | Macrocytic anemia (HP:0001972) | 3.30424290 |
12 | Pancreatic fibrosis (HP:0100732) | 3.26007282 |
13 | Maternal diabetes (HP:0009800) | 3.22819368 |
14 | Congenital, generalized hypertrichosis (HP:0004540) | 3.18588954 |
15 | Increased hepatocellular lipid droplets (HP:0006565) | 3.16732361 |
16 | Progressive cerebellar ataxia (HP:0002073) | 3.13885989 |
17 | True hermaphroditism (HP:0010459) | 3.13870141 |
18 | Abnormality of midbrain morphology (HP:0002418) | 3.08104701 |
19 | Molar tooth sign on MRI (HP:0002419) | 3.08104701 |
20 | Optic nerve hypoplasia (HP:0000609) | 3.03780555 |
21 | Absent septum pellucidum (HP:0001331) | 2.97832450 |
22 | Lipid accumulation in hepatocytes (HP:0006561) | 2.96227477 |
23 | Pancreatic cysts (HP:0001737) | 2.94816532 |
24 | Sclerocornea (HP:0000647) | 2.92875373 |
25 | Esophageal atresia (HP:0002032) | 2.83039145 |
26 | Increased CSF lactate (HP:0002490) | 2.78297774 |
27 | Optic disc pallor (HP:0000543) | 2.75882335 |
28 | Anophthalmia (HP:0000528) | 2.74529376 |
29 | Renal Fanconi syndrome (HP:0001994) | 2.71390151 |
30 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.68851033 |
31 | Abnormality of the labia minora (HP:0012880) | 2.67243138 |
32 | Pendular nystagmus (HP:0012043) | 2.63892565 |
33 | Congenital stationary night blindness (HP:0007642) | 2.53991292 |
34 | Abnormal number of incisors (HP:0011064) | 2.53802687 |
35 | Myokymia (HP:0002411) | 2.52978526 |
36 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.51365281 |
37 | Pallor (HP:0000980) | 2.49509360 |
38 | Abnormality of renal resorption (HP:0011038) | 2.47488002 |
39 | Nephronophthisis (HP:0000090) | 2.46734476 |
40 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.44233425 |
41 | Methylmalonic acidemia (HP:0002912) | 2.43100339 |
42 | Abnormality of the septum pellucidum (HP:0007375) | 2.41936944 |
43 | Methylmalonic aciduria (HP:0012120) | 2.40687961 |
44 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.40125762 |
45 | Gastrointestinal atresia (HP:0002589) | 2.39075092 |
46 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.38289473 |
47 | Medial flaring of the eyebrow (HP:0010747) | 2.32072240 |
48 | Cerebral edema (HP:0002181) | 2.28875430 |
49 | 3-Methylglutaconic aciduria (HP:0003535) | 2.27230064 |
50 | Anencephaly (HP:0002323) | 2.24423815 |
51 | Chronic hepatic failure (HP:0100626) | 2.21218848 |
52 | Abolished electroretinogram (ERG) (HP:0000550) | 2.15191738 |
53 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.14040276 |
54 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.11743588 |
55 | Abnormal ciliary motility (HP:0012262) | 2.03763128 |
56 | Abnormality of urine glucose concentration (HP:0011016) | 2.01960124 |
57 | Glycosuria (HP:0003076) | 2.01960124 |
58 | Hyperphosphaturia (HP:0003109) | 2.01913937 |
59 | Exertional dyspnea (HP:0002875) | 2.01762615 |
60 | Leukodystrophy (HP:0002415) | 2.01440213 |
61 | Abnormality of alanine metabolism (HP:0010916) | 2.00457840 |
62 | Hyperalaninemia (HP:0003348) | 2.00457840 |
63 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.00457840 |
64 | Chronic bronchitis (HP:0004469) | 1.99609837 |
65 | Gait imbalance (HP:0002141) | 1.98787937 |
66 | Male pseudohermaphroditism (HP:0000037) | 1.98024246 |
67 | Agitation (HP:0000713) | 1.96509599 |
68 | Hepatocellular necrosis (HP:0001404) | 1.96407703 |
69 | Colon cancer (HP:0003003) | 1.96002093 |
70 | Retinal dysplasia (HP:0007973) | 1.92375964 |
71 | Attenuation of retinal blood vessels (HP:0007843) | 1.90677567 |
72 | Increased intramyocellular lipid droplets (HP:0012240) | 1.89334798 |
73 | Hepatic necrosis (HP:0002605) | 1.87844205 |
74 | Lissencephaly (HP:0001339) | 1.86012466 |
75 | Median cleft lip (HP:0000161) | 1.85314116 |
76 | Hyperventilation (HP:0002883) | 1.84245360 |
77 | Abnormality of the renal medulla (HP:0100957) | 1.81401055 |
78 | Abnormality of DNA repair (HP:0003254) | 1.79272981 |
79 | Decreased central vision (HP:0007663) | 1.76212247 |
80 | Broad-based gait (HP:0002136) | 1.76112801 |
81 | Increased serum lactate (HP:0002151) | 1.75375468 |
82 | Cystic liver disease (HP:0006706) | 1.75328379 |
83 | Congenital primary aphakia (HP:0007707) | 1.74331495 |
84 | Growth hormone deficiency (HP:0000824) | 1.74185415 |
85 | Aplasia/Hypoplasia affecting the fundus (HP:0008057) | 1.73806131 |
86 | Hypomagnesemia (HP:0002917) | 1.73288316 |
87 | Nephrogenic diabetes insipidus (HP:0009806) | 1.73126343 |
88 | Genital tract atresia (HP:0001827) | 1.71942656 |
89 | Neuroendocrine neoplasm (HP:0100634) | 1.69430204 |
90 | Vaginal atresia (HP:0000148) | 1.69033377 |
91 | Large for gestational age (HP:0001520) | 1.67490271 |
92 | Absent/shortened dynein arms (HP:0200106) | 1.67327376 |
93 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.67327376 |
94 | Abnormal urine phosphate concentration (HP:0012599) | 1.67248313 |
95 | Abnormality of magnesium homeostasis (HP:0004921) | 1.66017982 |
96 | Type II lissencephaly (HP:0007260) | 1.65893082 |
97 | Epileptic encephalopathy (HP:0200134) | 1.65790577 |
98 | Bony spicule pigmentary retinopathy (HP:0007737) | 1.64720297 |
99 | Generalized aminoaciduria (HP:0002909) | 1.64559543 |
100 | Aplastic anemia (HP:0001915) | 1.64178320 |
Rank | Gene Set | Z-score |
---|---|---|
1 | STK16 | 6.01967606 |
2 | PNCK | 4.17385007 |
3 | ZAK | 3.49205342 |
4 | CASK | 3.12883241 |
5 | WNK3 | 2.70232368 |
6 | MAPK15 | 2.55911747 |
7 | NUAK1 | 2.33124196 |
8 | WNK4 | 2.28719093 |
9 | VRK1 | 2.27218456 |
10 | WEE1 | 2.15955940 |
11 | TLK1 | 2.13802048 |
12 | CDC7 | 1.87093164 |
13 | VRK2 | 1.84407003 |
14 | DYRK2 | 1.81801954 |
15 | MARK1 | 1.79236784 |
16 | GRK1 | 1.69237093 |
17 | NTRK3 | 1.67159423 |
18 | ADRBK2 | 1.58931693 |
19 | MAP4K2 | 1.54351824 |
20 | MAPK13 | 1.51192138 |
21 | TNIK | 1.46020898 |
22 | TAF1 | 1.45987872 |
23 | BUB1 | 1.45973017 |
24 | MAP2K7 | 1.42939003 |
25 | PINK1 | 1.40164461 |
26 | NTRK2 | 1.39534776 |
27 | BMPR1B | 1.38407860 |
28 | DYRK3 | 1.23851191 |
29 | FRK | 1.23421008 |
30 | EPHB2 | 1.17585892 |
31 | KDR | 1.11288783 |
32 | MAP3K4 | 1.11039928 |
33 | PLK3 | 1.07606604 |
34 | PRKCG | 0.95847496 |
35 | INSRR | 0.94288769 |
36 | BRSK2 | 0.89899826 |
37 | PLK4 | 0.89188646 |
38 | TIE1 | 0.88654170 |
39 | RPS6KA4 | 0.83193400 |
40 | TSSK6 | 0.82308736 |
41 | PASK | 0.81857589 |
42 | EPHA4 | 0.81675713 |
43 | PAK3 | 0.79153994 |
44 | BCKDK | 0.77641362 |
45 | SIK2 | 0.77495728 |
46 | TYRO3 | 0.73449549 |
47 | STK39 | 0.72586690 |
48 | NEK2 | 0.70560392 |
49 | MAP3K11 | 0.69366666 |
50 | OXSR1 | 0.68865986 |
51 | ADRBK1 | 0.67522781 |
52 | MINK1 | 0.67140063 |
53 | LATS1 | 0.66998710 |
54 | STK24 | 0.65349580 |
55 | PLK1 | 0.64314323 |
56 | STK38L | 0.63193586 |
57 | PHKG2 | 0.62402488 |
58 | PHKG1 | 0.62402488 |
59 | STK3 | 0.62294563 |
60 | CDK3 | 0.61146927 |
61 | NME1 | 0.60619992 |
62 | AURKA | 0.58945530 |
63 | UHMK1 | 0.58062013 |
64 | CSNK1E | 0.57378002 |
65 | CDK8 | 0.56411792 |
66 | PIK3CA | 0.54458278 |
67 | GRK7 | 0.54208262 |
68 | TAOK3 | 0.53900548 |
69 | DYRK1A | 0.52765371 |
70 | CHEK2 | 0.51833231 |
71 | DMPK | 0.49056883 |
72 | PRKACA | 0.45401306 |
73 | BRSK1 | 0.45060966 |
74 | MAP2K4 | 0.44689310 |
75 | RPS6KA5 | 0.44677790 |
76 | MAP3K10 | 0.43075019 |
77 | ATR | 0.42246596 |
78 | PRKCQ | 0.41774615 |
79 | PRKCE | 0.40921525 |
80 | TGFBR1 | 0.40516650 |
81 | PKN1 | 0.39780591 |
82 | SGK223 | 0.39122598 |
83 | SGK494 | 0.39122598 |
84 | DAPK2 | 0.39022856 |
85 | PLK2 | 0.38634929 |
86 | PRKG1 | 0.37711506 |
87 | MST4 | 0.37579780 |
88 | CAMK2A | 0.36853799 |
89 | TEC | 0.36533808 |
90 | LIMK1 | 0.34911101 |
91 | MKNK2 | 0.34789411 |
92 | TXK | 0.34475883 |
93 | PIM1 | 0.34019584 |
94 | CSNK1A1 | 0.33507115 |
95 | CSNK2A1 | 0.32460331 |
96 | CAMK1 | 0.31758849 |
97 | DAPK3 | 0.31011648 |
98 | SGK1 | 0.30678929 |
99 | CSNK2A2 | 0.29946701 |
100 | PRKDC | 0.27417589 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.86783190 |
2 | Ribosome_Homo sapiens_hsa03010 | 4.64062176 |
3 | Parkinsons disease_Homo sapiens_hsa05012 | 4.04126265 |
4 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.92161233 |
5 | Alzheimers disease_Homo sapiens_hsa05010 | 2.84611150 |
6 | Protein export_Homo sapiens_hsa03060 | 2.82747348 |
7 | Huntingtons disease_Homo sapiens_hsa05016 | 2.80382698 |
8 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.53338576 |
9 | Nicotine addiction_Homo sapiens_hsa05033 | 2.33959192 |
10 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.26030841 |
11 | RNA polymerase_Homo sapiens_hsa03020 | 2.24902060 |
12 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 2.10214845 |
13 | Proteasome_Homo sapiens_hsa03050 | 1.95986948 |
14 | Homologous recombination_Homo sapiens_hsa03440 | 1.77411306 |
15 | Phototransduction_Homo sapiens_hsa04744 | 1.75739720 |
16 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.74625624 |
17 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.73508869 |
18 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.59647303 |
19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.49165762 |
20 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.43903715 |
21 | Mismatch repair_Homo sapiens_hsa03430 | 1.39625895 |
22 | Taste transduction_Homo sapiens_hsa04742 | 1.38991156 |
23 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.34623411 |
24 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.30023326 |
25 | Spliceosome_Homo sapiens_hsa03040 | 1.27779703 |
26 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.27349305 |
27 | Sulfur relay system_Homo sapiens_hsa04122 | 1.20865668 |
28 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.20750858 |
29 | RNA degradation_Homo sapiens_hsa03018 | 1.16870187 |
30 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.12999472 |
31 | Insulin secretion_Homo sapiens_hsa04911 | 1.12676416 |
32 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.09583829 |
33 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.08180185 |
34 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.05634849 |
35 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.04292967 |
36 | Cocaine addiction_Homo sapiens_hsa05030 | 1.00932934 |
37 | GABAergic synapse_Homo sapiens_hsa04727 | 0.97485207 |
38 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.95787747 |
39 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.90847743 |
40 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.89679325 |
41 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.89469339 |
42 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.89102121 |
43 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.84494304 |
44 | Olfactory transduction_Homo sapiens_hsa04740 | 0.84252173 |
45 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.79973890 |
46 | Morphine addiction_Homo sapiens_hsa05032 | 0.78110483 |
47 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.78023543 |
48 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.77582558 |
49 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.75417752 |
50 | Purine metabolism_Homo sapiens_hsa00230 | 0.73667617 |
51 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.70454244 |
52 | Circadian entrainment_Homo sapiens_hsa04713 | 0.69940594 |
53 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.69875377 |
54 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.69604668 |
55 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.68841255 |
56 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.67872142 |
57 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.67387728 |
58 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.66871052 |
59 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.63798354 |
60 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.63027164 |
61 | Peroxisome_Homo sapiens_hsa04146 | 0.61766277 |
62 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.60965987 |
63 | DNA replication_Homo sapiens_hsa03030 | 0.60021116 |
64 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.59850751 |
65 | Metabolic pathways_Homo sapiens_hsa01100 | 0.58597806 |
66 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.57285912 |
67 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.56087942 |
68 | Retinol metabolism_Homo sapiens_hsa00830 | 0.55744019 |
69 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.54513935 |
70 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.54000307 |
71 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.52721027 |
72 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.50448177 |
73 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.50427134 |
74 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.48312105 |
75 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.45283459 |
76 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.43057480 |
77 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.42389669 |
78 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.42372471 |
79 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.41115790 |
80 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.40442367 |
81 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.40345876 |
82 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.39642283 |
83 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.38250864 |
84 | RNA transport_Homo sapiens_hsa03013 | 0.38155839 |
85 | Base excision repair_Homo sapiens_hsa03410 | 0.37548876 |
86 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.37133029 |
87 | Melanogenesis_Homo sapiens_hsa04916 | 0.36930764 |
88 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.36375659 |
89 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.34815165 |
90 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.33927628 |
91 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.33803957 |
92 | Salivary secretion_Homo sapiens_hsa04970 | 0.31725667 |
93 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.31411968 |
94 | Axon guidance_Homo sapiens_hsa04360 | 0.31231730 |
95 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.30241421 |
96 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.28078949 |
97 | Mineral absorption_Homo sapiens_hsa04978 | 0.27294946 |
98 | Gap junction_Homo sapiens_hsa04540 | 0.26604841 |
99 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.25517942 |
100 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.22610714 |