UPF3AP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)6.81424087
2viral transcription (GO:0019083)5.82623319
3ribosomal small subunit biogenesis (GO:0042274)5.56642740
4translational termination (GO:0006415)5.49243696
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.15602890
6ATP synthesis coupled proton transport (GO:0015986)5.15602890
7behavioral response to nicotine (GO:0035095)5.09759245
8maturation of SSU-rRNA (GO:0030490)4.77486020
9pyrimidine nucleobase catabolic process (GO:0006208)4.71033702
10protein localization to cilium (GO:0061512)4.69132893
11phenol-containing compound catabolic process (GO:0019336)4.66895695
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.56575145
13cardiovascular system development (GO:0072358)4.54525920
14translational elongation (GO:0006414)4.49973097
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.37385966
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.37007413
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.33087704
18cotranslational protein targeting to membrane (GO:0006613)4.31069524
19protein targeting to ER (GO:0045047)4.29528726
20positive regulation of T cell apoptotic process (GO:0070234)4.26400884
21negative regulation of macrophage differentiation (GO:0045650)4.22068032
22cellular protein complex disassembly (GO:0043624)4.18185437
23establishment of protein localization to endoplasmic reticulum (GO:0072599)4.10632843
24regulation of glycogen (starch) synthase activity (GO:2000465)4.09203140
25ribosomal small subunit assembly (GO:0000028)4.04288296
26respiratory electron transport chain (GO:0022904)4.03091894
27viral life cycle (GO:0019058)3.98926718
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.97110543
29electron transport chain (GO:0022900)3.95120692
30protein localization to endoplasmic reticulum (GO:0070972)3.89423651
31camera-type eye morphogenesis (GO:0048593)3.83537452
32negative regulation of T cell differentiation in thymus (GO:0033085)3.82268043
33phosphorelay signal transduction system (GO:0000160)3.73410476
34cerebellar granule cell differentiation (GO:0021707)3.73150460
35regulation of RNA export from nucleus (GO:0046831)3.70157853
36dopamine biosynthetic process (GO:0042416)3.69433289
37negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.66027345
38negative regulation of translation, ncRNA-mediated (GO:0040033)3.66027345
39regulation of translation, ncRNA-mediated (GO:0045974)3.66027345
40nucleobase catabolic process (GO:0046113)3.65455846
41protein complex disassembly (GO:0043241)3.60111583
42synaptic transmission, cholinergic (GO:0007271)3.59087974
43ribosomal large subunit biogenesis (GO:0042273)3.56475275
44centrosome duplication (GO:0051298)3.55414938
45embryonic body morphogenesis (GO:0010172)3.53822286
46rRNA catabolic process (GO:0016075)3.50425390
47negative regulation of cAMP-mediated signaling (GO:0043951)3.49481158
48substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.44372797
49substrate-independent telencephalic tangential migration (GO:0021826)3.44372797
50microtubule nucleation (GO:0007020)3.44236548
51prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.41373440
52cell-cell junction maintenance (GO:0045217)3.32593425
53pseudouridine synthesis (GO:0001522)3.32500617
54body morphogenesis (GO:0010171)3.29739982
55macromolecular complex disassembly (GO:0032984)3.29699482
56negative regulation of transcription regulatory region DNA binding (GO:2000678)3.22316819
57neuron remodeling (GO:0016322)3.21960706
58translational initiation (GO:0006413)3.21800725
59peristalsis (GO:0030432)3.14718247
60regulation of catecholamine metabolic process (GO:0042069)3.13396074
61regulation of dopamine metabolic process (GO:0042053)3.13396074
62negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.12802087
63negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.11930624
64protein localization to synapse (GO:0035418)2.97244761
65positive regulation of synapse assembly (GO:0051965)2.96062996
66histone H2B ubiquitination (GO:0033523)2.95327793
67behavioral response to ethanol (GO:0048149)2.92519496
68positive regulation of protein homodimerization activity (GO:0090073)2.91396592
69neuron maturation (GO:0042551)2.87031278
70positive regulation of lymphocyte apoptotic process (GO:0070230)2.86698252
71kidney morphogenesis (GO:0060993)2.82543178
72protein targeting to membrane (GO:0006612)2.79898309
73epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.79785955
74negative regulation of cell cycle G2/M phase transition (GO:1902750)2.79539121
75regulation of hydrogen peroxide metabolic process (GO:0010310)2.77321747
76ATP biosynthetic process (GO:0006754)2.76481416
77regulation of synaptic transmission, dopaminergic (GO:0032225)2.75921917
78regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.75656143
79tryptophan catabolic process (GO:0006569)2.73815789
80indole-containing compound catabolic process (GO:0042436)2.73815789
81indolalkylamine catabolic process (GO:0046218)2.73815789
82protein-cofactor linkage (GO:0018065)2.72190019
83regulation of female receptivity (GO:0045924)2.71393533
84alanine transport (GO:0032328)2.69416287
85protein peptidyl-prolyl isomerization (GO:0000413)2.69085854
86epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.68512310
87viral mRNA export from host cell nucleus (GO:0046784)2.67429503
88ventricular system development (GO:0021591)2.66875668
89negative regulation of DNA-templated transcription, elongation (GO:0032785)2.66382839
90behavioral response to cocaine (GO:0048148)2.64290049
91negative regulation of telomerase activity (GO:0051974)2.63490127
92purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.62747489
93regulation of telomerase activity (GO:0051972)2.62421306
94endoderm formation (GO:0001706)2.60160125
95organic cation transport (GO:0015695)2.58574369
96cell differentiation in hindbrain (GO:0021533)2.57339728
97purine nucleoside triphosphate biosynthetic process (GO:0009145)2.56564077
98axonemal dynein complex assembly (GO:0070286)2.54066107
99nuclear-transcribed mRNA catabolic process (GO:0000956)2.54055252
100response to parathyroid hormone (GO:0071107)2.53498634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.84369018
2EZH2_22144423_ChIP-Seq_EOC_Human6.67319106
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.69148986
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.82410993
5IKZF1_21737484_ChIP-ChIP_HCT116_Human2.74678128
6EZH2_27294783_Chip-Seq_ESCs_Mouse2.64757719
7BMI1_23680149_ChIP-Seq_NPCS_Mouse2.46511875
8ERG_21242973_ChIP-ChIP_JURKAT_Human2.46471774
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.40931372
10REST_21632747_ChIP-Seq_MESCs_Mouse2.40782155
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.35428216
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.33669787
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32880579
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30260260
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29632762
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.29490586
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.22575721
18CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.20203824
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08692733
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02086846
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02086846
22VDR_22108803_ChIP-Seq_LS180_Human1.87392367
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86822927
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.86816513
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.81208119
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.79175264
27ZNF274_21170338_ChIP-Seq_K562_Hela1.75965268
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.75270087
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.72689875
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70837084
31RNF2_27304074_Chip-Seq_NSC_Mouse1.67708085
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.67551494
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66558797
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57108562
35GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.53373173
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49839682
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49839682
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49769330
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49373621
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.49015238
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48961463
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47983623
43SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.42111321
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.40973248
45CTCF_27219007_Chip-Seq_Bcells_Human1.40527001
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.37246885
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34246489
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34184490
49IRF1_19129219_ChIP-ChIP_H3396_Human1.32105829
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.30936872
51RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29410559
52SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25804997
53CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24001349
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21833089
55BCL6_27268052_Chip-Seq_Bcells_Human1.14417590
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.12539421
57DROSHA_22980978_ChIP-Seq_HELA_Human1.11774855
58STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.10354006
59TAF2_19829295_ChIP-Seq_ESCs_Human1.08570709
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08357096
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08188866
62OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07903105
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07825966
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.07744240
65EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07322424
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04934316
67GABP_17652178_ChIP-ChIP_JURKAT_Human1.04485739
68MYC_18940864_ChIP-ChIP_HL60_Human1.04406432
69ERA_21632823_ChIP-Seq_H3396_Human1.04300747
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02720181
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.02036479
72E2F1_20622854_ChIP-Seq_HELA_Human0.94695635
73AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94355992
74OCT4_19829295_ChIP-Seq_ESCs_Human0.93478336
75YY1_22570637_ChIP-Seq_MALME-3M_Human0.93155066
76TP53_22127205_ChIP-Seq_IMR90_Human0.92587131
77ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92504606
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92435706
79KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90957235
80TET1_21451524_ChIP-Seq_MESCs_Mouse0.90176791
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90145058
82STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88507615
83CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88395528
84SOX3_22085726_ChIP-Seq_NPCs_Mouse0.87372473
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87344346
86NCOR_22424771_ChIP-Seq_293T_Human0.86256368
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85790683
88TP53_22573176_ChIP-Seq_HFKS_Human0.84778314
89FOXH1_21741376_ChIP-Seq_EPCs_Human0.84601554
90JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.84186418
91GATA3_21878914_ChIP-Seq_MCF-7_Human0.83946774
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.82947325
93NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82484073
94ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81009974
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79468199
96KLF4_19829295_ChIP-Seq_ESCs_Human0.77786500
97SMAD4_21741376_ChIP-Seq_ESCs_Human0.77021581
98THAP11_20581084_ChIP-Seq_MESCs_Mouse0.77010605
99P53_21459846_ChIP-Seq_SAOS-2_Human0.75115126
100FLI1_21867929_ChIP-Seq_CD8_Mouse0.74918477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting5.41839277
2MP0009379_abnormal_foot_pigmentation5.21520300
3MP0006292_abnormal_olfactory_placode3.72117892
4MP0003123_paternal_imprinting3.49895785
5MP0009053_abnormal_anal_canal2.87767303
6MP0005423_abnormal_somatic_nervous2.61413888
7MP0004885_abnormal_endolymph2.58190301
8MP0006276_abnormal_autonomic_nervous2.45393832
9MP0008789_abnormal_olfactory_epithelium2.40870677
10MP0003121_genomic_imprinting2.31213274
11MP0004043_abnormal_pH_regulation2.29073838
12MP0000778_abnormal_nervous_system2.14738173
13MP0004142_abnormal_muscle_tone2.06969591
14MP0002163_abnormal_gland_morphology2.00818126
15MP0009046_muscle_twitch1.94334652
16MP0001188_hyperpigmentation1.93413758
17MP0005499_abnormal_olfactory_system1.89965589
18MP0005394_taste/olfaction_phenotype1.89965589
19MP0000631_abnormal_neuroendocrine_gland1.79259269
20MP0006072_abnormal_retinal_apoptosis1.75219240
21MP0003646_muscle_fatigue1.73957718
22MP0000372_irregular_coat_pigmentation1.72791966
23MP0003880_abnormal_central_pattern1.71307297
24MP0002638_abnormal_pupillary_reflex1.69962944
25MP0008877_abnormal_DNA_methylation1.67975428
26MP0004742_abnormal_vestibular_system1.61434082
27MP0002909_abnormal_adrenal_gland1.55330825
28MP0001905_abnormal_dopamine_level1.55190105
29MP0003635_abnormal_synaptic_transmissio1.51069202
30MP0002734_abnormal_mechanical_nocicepti1.48814476
31MP0001485_abnormal_pinna_reflex1.48530347
32MP0002272_abnormal_nervous_system1.48218503
33MP0003136_yellow_coat_color1.47423667
34MP0005551_abnormal_eye_electrophysiolog1.46069297
35MP0004859_abnormal_synaptic_plasticity1.45692880
36MP0005360_urolithiasis1.42990682
37MP0002160_abnormal_reproductive_system1.40091783
38MP0002735_abnormal_chemical_nociception1.39426011
39MP0002063_abnormal_learning/memory/cond1.38018952
40MP0009745_abnormal_behavioral_response1.37723605
41MP0002876_abnormal_thyroid_physiology1.32636990
42MP0002752_abnormal_somatic_nervous1.31515904
43MP0000955_abnormal_spinal_cord1.31349441
44MP0002184_abnormal_innervation1.30638433
45MP0001970_abnormal_pain_threshold1.30399875
46MP0005377_hearing/vestibular/ear_phenot1.29661452
47MP0003878_abnormal_ear_physiology1.29661452
48MP0000049_abnormal_middle_ear1.29352570
49MP0005645_abnormal_hypothalamus_physiol1.28768159
50MP0002882_abnormal_neuron_morphology1.28464096
51MP0005195_abnormal_posterior_eye1.27336354
52MP0002822_catalepsy1.27214952
53MP0001968_abnormal_touch/_nociception1.25022100
54MP0002557_abnormal_social/conspecific_i1.22554063
55MP0005389_reproductive_system_phenotype1.21533948
56MP0003385_abnormal_body_wall1.17220548
57MP0004133_heterotaxia1.16604313
58MP0002733_abnormal_thermal_nociception1.15766775
59MP0000427_abnormal_hair_cycle1.14034388
60MP0002572_abnormal_emotion/affect_behav1.12381996
61MP0002064_seizures1.10366452
62MP0002095_abnormal_skin_pigmentation1.10305037
63MP0001440_abnormal_grooming_behavior1.09260003
64MP0003942_abnormal_urinary_system1.08873620
65MP0002067_abnormal_sensory_capabilities1.06198535
66MP0003938_abnormal_ear_development1.05295023
67MP0000678_abnormal_parathyroid_gland1.02985125
68MP0001919_abnormal_reproductive_system0.99715816
69MP0003861_abnormal_nervous_system0.99649042
70MP0001486_abnormal_startle_reflex0.97786121
71MP0005379_endocrine/exocrine_gland_phen0.96275079
72MP0000026_abnormal_inner_ear0.95333775
73MP0005646_abnormal_pituitary_gland0.94423178
74MP0002234_abnormal_pharynx_morphology0.94381004
75MP0002938_white_spotting0.94174711
76MP0001542_abnormal_bone_strength0.93235892
77MP0003879_abnormal_hair_cell0.92582033
78MP0004811_abnormal_neuron_physiology0.91626800
79MP0002152_abnormal_brain_morphology0.90123362
80MP0001293_anophthalmia0.88509212
81MP0004130_abnormal_muscle_cell0.85332857
82MP0001286_abnormal_eye_development0.82852531
83MP0001963_abnormal_hearing_physiology0.81729870
84MP0002837_dystrophic_cardiac_calcinosis0.81288391
85MP0002653_abnormal_ependyma_morphology0.81037546
86MP0002066_abnormal_motor_capabilities/c0.80006742
87MP0004145_abnormal_muscle_electrophysio0.80000435
88MP0002229_neurodegeneration0.75753821
89MP0002928_abnormal_bile_duct0.75268562
90MP0000534_abnormal_ureter_morphology0.74981926
91MP0005257_abnormal_intraocular_pressure0.74064862
92MP0002138_abnormal_hepatobiliary_system0.73100644
93MP0008875_abnormal_xenobiotic_pharmacok0.71541315
94MP0005174_abnormal_tail_pigmentation0.71227661
95MP0002210_abnormal_sex_determination0.69837466
96MP0003698_abnormal_male_reproductive0.68836283
97MP0000015_abnormal_ear_pigmentation0.67861629
98MP0002697_abnormal_eye_size0.67108015
99MP0008872_abnormal_physiological_respon0.66632574
100MP0003283_abnormal_digestive_organ0.66401101

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)3.73683600
2Oligodactyly (hands) (HP:0001180)3.57561553
3Absent rod-and cone-mediated responses on ERG (HP:0007688)3.54666001
4Abnormality of cells of the erythroid lineage (HP:0012130)3.50812530
5Anencephaly (HP:0002323)3.47516875
6Medial flaring of the eyebrow (HP:0010747)3.42491862
7Sclerocornea (HP:0000647)3.35597687
8Pancreatic fibrosis (HP:0100732)3.35381389
9Ectopic kidney (HP:0000086)3.29598698
10Acute necrotizing encephalopathy (HP:0006965)3.23257145
11Limb dystonia (HP:0002451)3.12321327
12Broad distal phalanx of finger (HP:0009836)3.10188641
13Volvulus (HP:0002580)3.04898473
14Abnormality of midbrain morphology (HP:0002418)3.03463582
15Molar tooth sign on MRI (HP:0002419)3.03463582
16Abnormal mitochondria in muscle tissue (HP:0008316)3.00792726
17Macrocytic anemia (HP:0001972)2.92888550
18Abnormality of the renal cortex (HP:0011035)2.91363948
19Abnormal number of erythroid precursors (HP:0012131)2.80870097
20Mitochondrial inheritance (HP:0001427)2.76866692
21True hermaphroditism (HP:0010459)2.76761508
22Neoplasm of the adrenal cortex (HP:0100641)2.75538997
23Myokymia (HP:0002411)2.70683407
24Chronic hepatic failure (HP:0100626)2.67187726
25Metaphyseal dysplasia (HP:0100255)2.63738147
26Pancreatic cysts (HP:0001737)2.60701301
27Nephronophthisis (HP:0000090)2.59993644
28Oligodactyly (HP:0012165)2.59223475
29Acute encephalopathy (HP:0006846)2.58839380
30Abnormal respiratory motile cilium physiology (HP:0012261)2.57915382
31Abnormal pancreas size (HP:0012094)2.54452921
32Progressive macrocephaly (HP:0004481)2.54371004
33Increased hepatocellular lipid droplets (HP:0006565)2.47951492
34Absent thumb (HP:0009777)2.47556040
35Abnormal rod and cone electroretinograms (HP:0008323)2.47275106
36Cystic liver disease (HP:0006706)2.46883361
37Abnormality of renal resorption (HP:0011038)2.45670947
38Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.45307976
39Aplasia/Hypoplasia of the lens (HP:0008063)2.44179528
40Fetal akinesia sequence (HP:0001989)2.41934060
41Occipital encephalocele (HP:0002085)2.41600993
42Aplasia/Hypoplasia of the macula (HP:0008059)2.41452305
43Abnormality of the renal medulla (HP:0100957)2.39434281
44Concave nail (HP:0001598)2.38581862
45Nephrogenic diabetes insipidus (HP:0009806)2.38489876
46Gait imbalance (HP:0002141)2.33918370
47Pendular nystagmus (HP:0012043)2.33798312
48Increased CSF lactate (HP:0002490)2.31004002
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30798580
50Abnormality of the phalanges of the hallux (HP:0010057)2.30527610
51Abnormal ciliary motility (HP:0012262)2.29605179
52Renal Fanconi syndrome (HP:0001994)2.28616340
53Aplasia/Hypoplasia affecting the retina (HP:0008061)2.23481725
54Esophageal atresia (HP:0002032)2.22253115
55Hypoplasia of the radius (HP:0002984)2.19264517
56High anterior hairline (HP:0009890)2.18720568
57Postaxial foot polydactyly (HP:0001830)2.18315953
58Pallor (HP:0000980)2.17520079
59Hepatoblastoma (HP:0002884)2.16470667
60Congenital primary aphakia (HP:0007707)2.16325875
61Rectal prolapse (HP:0002035)2.15963815
62Abnormal respiratory motile cilium morphology (HP:0005938)2.15331046
63Abnormal respiratory epithelium morphology (HP:0012253)2.15331046
64Abnormal hair whorl (HP:0010721)2.15152554
65Renal cortical cysts (HP:0000803)2.15044986
66Neonatal hypoglycemia (HP:0001998)2.12566691
67Abnormality of the 4th metacarpal (HP:0010012)2.10109610
68Hyperventilation (HP:0002883)2.08681621
69Poor coordination (HP:0002370)2.06426011
70Lipid accumulation in hepatocytes (HP:0006561)2.05842290
71Diastasis recti (HP:0001540)2.04655548
72Increased corneal curvature (HP:0100692)2.03962729
73Keratoconus (HP:0000563)2.03962729
74Rib fusion (HP:0000902)2.02544629
75Preaxial hand polydactyly (HP:0001177)2.01791244
76Dyskinesia (HP:0100660)2.01773936
77Abnormality of the intervertebral disk (HP:0005108)2.00545232
78Depressed nasal ridge (HP:0000457)2.00179716
79Absent/shortened dynein arms (HP:0200106)1.98656946
80Dynein arm defect of respiratory motile cilia (HP:0012255)1.98656946
81Pachygyria (HP:0001302)1.98348216
82Chronic bronchitis (HP:0004469)1.97991706
8311 pairs of ribs (HP:0000878)1.96054774
84Congenital stationary night blindness (HP:0007642)1.95332003
85Abnormal number of incisors (HP:0011064)1.94173739
86Visual hallucinations (HP:0002367)1.91736698
87Testicular atrophy (HP:0000029)1.91289981
88Impulsivity (HP:0100710)1.90812229
89Anomalous pulmonary venous return (HP:0010772)1.89848454
90Absent phalangeal crease (HP:0006109)1.88239387
91Type II lissencephaly (HP:0007260)1.83285373
92Aplasia/Hypoplasia of the tongue (HP:0010295)1.82985177
93Furrowed tongue (HP:0000221)1.82076913
94Forearm undergrowth (HP:0009821)1.81577086
95Lissencephaly (HP:0001339)1.81102661
96Osteomalacia (HP:0002749)1.78659573
97Adrenal hypoplasia (HP:0000835)1.77062880
98Akinesia (HP:0002304)1.75578425
99Tachypnea (HP:0002789)1.74814492
100Rhinitis (HP:0012384)1.74720362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K113.46174641
2NUAK13.42691397
3SIK23.28482184
4MAP3K43.11701086
5IRAK22.96428437
6CASK2.77126810
7TYRO32.59091435
8STK162.00668562
9ZAK1.97616541
10NTRK31.93675822
11ICK1.93623292
12NTRK21.91575989
13TAOK31.65973829
14EPHB11.64994363
15BMPR1B1.59752435
16FRK1.57342379
17NME21.51852826
18STK241.48201309
19MARK11.44810399
20CDK191.43234977
21LATS11.41102697
22MARK21.34517382
23MARK31.33838345
24WNK41.31206980
25MAP2K41.30809190
26PAK31.30204939
27EPHB21.29647742
28IRAK11.28856804
29AURKA1.27087617
30ADRBK21.26644615
31DYRK21.24850304
32PNCK1.22635877
33GRK11.19256402
34KIT1.16725311
35DMPK1.15865275
36MAP2K21.14955211
37FES1.14492567
38OXSR11.06800207
39TLK11.05465308
40MINK11.04948429
41PDGFRB1.03926415
42PRKCH1.02504384
43ABL20.93912034
44SIK10.93811366
45CAMK1G0.93669719
46GRK50.90954159
47CAMK10.90745194
48MAPK130.89786921
49CDK30.87155229
50MAP3K120.85341293
51DYRK1B0.84885814
52BRSK10.84591798
53LRRK20.83868482
54UHMK10.82403160
55CAMK1D0.80832900
56PRKCG0.80304808
57DDR20.78451883
58MAP2K70.76959321
59STK110.75836282
60FLT30.74465026
61BRAF0.72502385
62GRK60.70289380
63STK30.68519548
64DYRK1A0.65275699
65CDK50.64363663
66PRKCZ0.62770096
67STK390.59615515
68CSNK1E0.59525676
69RPS6KA60.57882559
70PRKACA0.57032001
71MUSK0.56551212
72SIK30.56430510
73PIK3CA0.55233443
74CAMKK10.54792768
75INSRR0.54519375
76MAPK120.54282527
77ACVR1B0.53307503
78MAP2K60.51316546
79MAP4K20.49992597
80DYRK30.48743314
81MAPK150.47519703
82PIM20.47260578
83PRKAA10.43579495
84CDK40.43463586
85NEK20.43298821
86TGFBR10.42466396
87SYK0.42338695
88PDK20.39658556
89PKN20.39386706
90PRKDC0.38755233
91CSNK2A20.36898187
92AKT10.36891509
93AURKB0.36681028
94CSF1R0.36523030
95PRKG10.35668817
96MAP3K70.35085440
97FYN0.34789343
98NEK10.34374966
99CSNK1G20.33564884
100PIM10.33144641

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.34181876
2Oxidative phosphorylation_Homo sapiens_hsa001904.57112285
3Parkinsons disease_Homo sapiens_hsa050124.34834463
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.48435417
5Sulfur relay system_Homo sapiens_hsa041223.41711673
6Alzheimers disease_Homo sapiens_hsa050103.06156002
7Huntingtons disease_Homo sapiens_hsa050163.00928290
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.58311099
9Nicotine addiction_Homo sapiens_hsa050332.56445174
10Cardiac muscle contraction_Homo sapiens_hsa042602.46496654
11Tryptophan metabolism_Homo sapiens_hsa003801.94874863
12Morphine addiction_Homo sapiens_hsa050321.83246442
13Cocaine addiction_Homo sapiens_hsa050301.81574859
14RNA polymerase_Homo sapiens_hsa030201.81172813
15Phototransduction_Homo sapiens_hsa047441.59658445
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.51412513
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44484614
18Phenylalanine metabolism_Homo sapiens_hsa003601.39045125
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.37000672
20Axon guidance_Homo sapiens_hsa043601.27920036
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22396885
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20123633
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14692069
24Olfactory transduction_Homo sapiens_hsa047401.10249902
25Linoleic acid metabolism_Homo sapiens_hsa005911.07180165
26GABAergic synapse_Homo sapiens_hsa047271.02753793
27Pyrimidine metabolism_Homo sapiens_hsa002401.01493231
28Tyrosine metabolism_Homo sapiens_hsa003501.01452760
29Dopaminergic synapse_Homo sapiens_hsa047281.00101948
30Ovarian steroidogenesis_Homo sapiens_hsa049130.99312666
31Vitamin B6 metabolism_Homo sapiens_hsa007500.98887562
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98380035
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94629093
34Glutamatergic synapse_Homo sapiens_hsa047240.91111387
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82841379
36Insulin secretion_Homo sapiens_hsa049110.81748599
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81088259
38Lysine degradation_Homo sapiens_hsa003100.78428445
39Circadian entrainment_Homo sapiens_hsa047130.74882077
40Amphetamine addiction_Homo sapiens_hsa050310.74145174
41Chemical carcinogenesis_Homo sapiens_hsa052040.74113505
42Fanconi anemia pathway_Homo sapiens_hsa034600.73382802
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73088557
44Cholinergic synapse_Homo sapiens_hsa047250.69782479
45Purine metabolism_Homo sapiens_hsa002300.69422022
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66864328
47Taste transduction_Homo sapiens_hsa047420.64397419
48Serotonergic synapse_Homo sapiens_hsa047260.62523341
49Butanoate metabolism_Homo sapiens_hsa006500.62509676
50Retinol metabolism_Homo sapiens_hsa008300.61500022
51Oxytocin signaling pathway_Homo sapiens_hsa049210.60946438
52beta-Alanine metabolism_Homo sapiens_hsa004100.58818792
53ABC transporters_Homo sapiens_hsa020100.58715623
54Protein export_Homo sapiens_hsa030600.58467768
55Homologous recombination_Homo sapiens_hsa034400.58298762
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56713300
57Calcium signaling pathway_Homo sapiens_hsa040200.55890439
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53972970
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52723677
60GnRH signaling pathway_Homo sapiens_hsa049120.51204724
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48867175
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.47788612
63cAMP signaling pathway_Homo sapiens_hsa040240.47455993
64Gastric acid secretion_Homo sapiens_hsa049710.47193645
65MAPK signaling pathway_Homo sapiens_hsa040100.45974329
66Metabolic pathways_Homo sapiens_hsa011000.45545500
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45035938
68Base excision repair_Homo sapiens_hsa034100.44920493
69DNA replication_Homo sapiens_hsa030300.44666258
70Selenocompound metabolism_Homo sapiens_hsa004500.43762869
71RNA degradation_Homo sapiens_hsa030180.42856908
72Nitrogen metabolism_Homo sapiens_hsa009100.42770289
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42218198
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.41873501
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40501229
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38778517
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38398396
78Salivary secretion_Homo sapiens_hsa049700.37038454
79Rap1 signaling pathway_Homo sapiens_hsa040150.35895284
80Bile secretion_Homo sapiens_hsa049760.34582398
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33456197
82Histidine metabolism_Homo sapiens_hsa003400.33099854
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32835449
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32437252
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.31794524
86Dilated cardiomyopathy_Homo sapiens_hsa054140.31271924
87Melanogenesis_Homo sapiens_hsa049160.31224951
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30631458
89Alcoholism_Homo sapiens_hsa050340.30178784
90Ras signaling pathway_Homo sapiens_hsa040140.29972449
91Hippo signaling pathway_Homo sapiens_hsa043900.29681328
92Wnt signaling pathway_Homo sapiens_hsa043100.28224524
93Renin secretion_Homo sapiens_hsa049240.28223188
94Arginine and proline metabolism_Homo sapiens_hsa003300.28130111
95Arachidonic acid metabolism_Homo sapiens_hsa005900.27677204
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27215734
97Fatty acid degradation_Homo sapiens_hsa000710.26656700
98Gap junction_Homo sapiens_hsa045400.26358213
99Notch signaling pathway_Homo sapiens_hsa043300.26349947
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26209424

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