UPF3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.53515987
2ribosomal small subunit assembly (GO:0000028)4.24557997
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.21388438
4mesenchymal cell differentiation involved in renal system development (GO:2001012)4.18264907
5mesenchymal cell differentiation involved in kidney development (GO:0072161)4.18264907
6regulation of nuclear cell cycle DNA replication (GO:0033262)4.13148553
7DNA ligation (GO:0006266)3.93771894
8chaperone-mediated protein transport (GO:0072321)3.69175816
9histone exchange (GO:0043486)3.65371387
10viral transcription (GO:0019083)3.63696656
11translational termination (GO:0006415)3.63189180
12presynaptic membrane assembly (GO:0097105)3.62485508
13intraciliary transport (GO:0042073)3.46948126
14DNA strand renaturation (GO:0000733)3.46581533
15DNA replication checkpoint (GO:0000076)3.40168748
16DNA replication-independent nucleosome organization (GO:0034724)3.38610711
17DNA replication-independent nucleosome assembly (GO:0006336)3.38610711
18kinetochore organization (GO:0051383)3.37209431
19maturation of SSU-rRNA (GO:0030490)3.36926080
20regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.31433530
21centriole assembly (GO:0098534)3.31050356
22keratinocyte development (GO:0003334)3.29466171
23respiratory electron transport chain (GO:0022904)3.26602550
24GTP biosynthetic process (GO:0006183)3.25396132
25pseudouridine synthesis (GO:0001522)3.24481917
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.24351877
27behavioral response to nicotine (GO:0035095)3.24034115
28kinetochore assembly (GO:0051382)3.23447571
29presynaptic membrane organization (GO:0097090)3.22672017
30electron transport chain (GO:0022900)3.21694735
31ribosomal small subunit biogenesis (GO:0042274)3.20463823
32cotranslational protein targeting to membrane (GO:0006613)3.20192767
33negative regulation of DNA-dependent DNA replication (GO:2000104)3.19200636
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.18678778
35protein neddylation (GO:0045116)3.13756417
36protein targeting to ER (GO:0045047)3.13292109
37regulation of timing of cell differentiation (GO:0048505)3.12333805
38poly(A)+ mRNA export from nucleus (GO:0016973)3.09845286
39centriole replication (GO:0007099)3.09668406
40guanosine-containing compound biosynthetic process (GO:1901070)3.08952241
41replication fork processing (GO:0031297)3.07670936
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06561172
43resolution of meiotic recombination intermediates (GO:0000712)3.05937654
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.02305582
45GMP metabolic process (GO:0046037)2.98393199
46regulation of rhodopsin mediated signaling pathway (GO:0022400)2.98222553
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.97772355
48kidney morphogenesis (GO:0060993)2.96350150
49microtubule depolymerization (GO:0007019)2.95218652
50translational elongation (GO:0006414)2.95208320
51respiratory chain complex IV assembly (GO:0008535)2.94992870
52regulation of DNA endoreduplication (GO:0032875)2.94825076
53regulation of pigment cell differentiation (GO:0050932)2.94593512
54protein complex biogenesis (GO:0070271)2.93774420
55GPI anchor biosynthetic process (GO:0006506)2.92795536
56nucleotide transmembrane transport (GO:1901679)2.91104709
57protein localization to endoplasmic reticulum (GO:0070972)2.91001940
58protein K6-linked ubiquitination (GO:0085020)2.87755753
59histone H3-K4 trimethylation (GO:0080182)2.84732101
60rhodopsin mediated signaling pathway (GO:0016056)2.83162390
61mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82714576
62mitochondrial respiratory chain complex I assembly (GO:0032981)2.82714576
63NADH dehydrogenase complex assembly (GO:0010257)2.82714576
64response to redox state (GO:0051775)2.80799099
65cellular protein complex disassembly (GO:0043624)2.80408973
66regulation of development, heterochronic (GO:0040034)2.79400736
67photoreceptor cell maintenance (GO:0045494)2.77817063
68termination of RNA polymerase III transcription (GO:0006386)2.76131708
69transcription elongation from RNA polymerase III promoter (GO:0006385)2.76131708
70ribosomal large subunit biogenesis (GO:0042273)2.74915680
71preassembly of GPI anchor in ER membrane (GO:0016254)2.74719206
72protein localization to kinetochore (GO:0034501)2.74485126
73synapsis (GO:0007129)2.72994541
74telomere maintenance via semi-conservative replication (GO:0032201)2.72367816
75signal peptide processing (GO:0006465)2.71718277
76nonmotile primary cilium assembly (GO:0035058)2.71584849
77translational initiation (GO:0006413)2.71224240
78CENP-A containing nucleosome assembly (GO:0034080)2.70940315
79viral life cycle (GO:0019058)2.69652853
80spliceosomal snRNP assembly (GO:0000387)2.68318057
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68167285
82tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68167285
83* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.67765387
84termination of RNA polymerase I transcription (GO:0006363)2.67181016
85regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.66861443
86regulation of mitotic spindle checkpoint (GO:1903504)2.66861443
87regulation of mRNA splicing, via spliceosome (GO:0048024)2.64860688
88nucleotide-excision repair, DNA gap filling (GO:0006297)2.63855263
89transcription elongation from RNA polymerase I promoter (GO:0006362)2.63613258
90maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.63211495
91DNA double-strand break processing (GO:0000729)2.61986108
92UTP biosynthetic process (GO:0006228)2.61959334
93DNA-dependent DNA replication (GO:0006261)2.61950824
94postsynaptic membrane organization (GO:0001941)2.61370128
95viral mRNA export from host cell nucleus (GO:0046784)2.60177096
96translation (GO:0006412)2.58373869
97axon ensheathment in central nervous system (GO:0032291)2.57722411
98central nervous system myelination (GO:0022010)2.57722411
99peptidyl-histidine modification (GO:0018202)2.56080081
100GPI anchor metabolic process (GO:0006505)2.55929564
101developmental pigmentation (GO:0048066)2.55111083
102eye photoreceptor cell development (GO:0042462)2.54967210
103establishment of integrated proviral latency (GO:0075713)2.54495707
104cytochrome complex assembly (GO:0017004)2.54449444
105positive regulation of mRNA processing (GO:0050685)2.54048677
106mitotic sister chromatid segregation (GO:0000070)2.53922905
107protein-cofactor linkage (GO:0018065)2.53816182
108cell differentiation involved in metanephros development (GO:0072202)2.53188013
109mitotic recombination (GO:0006312)2.52918456
110chromatin remodeling at centromere (GO:0031055)2.52785765
111dopamine transport (GO:0015872)2.51442122
112protein complex disassembly (GO:0043241)2.51040945
113meiotic chromosome segregation (GO:0045132)2.50565811
114microtubule polymerization or depolymerization (GO:0031109)2.49769154
115DNA strand elongation involved in DNA replication (GO:0006271)2.48494637
116spliceosomal complex assembly (GO:0000245)2.48478371
117macromolecular complex disassembly (GO:0032984)2.47264901
118photoreceptor cell development (GO:0042461)2.46230308
119negative regulation of transcription by competitive promoter binding (GO:0010944)2.45524038
120RNA capping (GO:0036260)2.44634312
1217-methylguanosine RNA capping (GO:0009452)2.44634312
122mannosylation (GO:0097502)2.44601735
123telomere maintenance via recombination (GO:0000722)2.44269274
124retina layer formation (GO:0010842)2.43985295
125sister chromatid segregation (GO:0000819)2.43406779
126organelle disassembly (GO:1903008)2.43249076
127mitochondrial respiratory chain complex assembly (GO:0033108)2.42469064
128tRNA processing (GO:0008033)2.41512674
129negative regulation of keratinocyte proliferation (GO:0010839)2.41170793
130atrial cardiac muscle cell action potential (GO:0086014)2.40967617
1317-methylguanosine mRNA capping (GO:0006370)2.40286903
132axoneme assembly (GO:0035082)2.40094673
133maturation of 5.8S rRNA (GO:0000460)2.38374096
134rRNA processing (GO:0006364)2.38365237
135somite development (GO:0061053)2.38212617
136dentate gyrus development (GO:0021542)2.37863106
137cellular component biogenesis (GO:0044085)2.36865187
138lymphoid progenitor cell differentiation (GO:0002320)2.36633161
139protein polyglutamylation (GO:0018095)2.36371482
140DNA damage response, detection of DNA damage (GO:0042769)2.35986394
141negative regulation of telomere maintenance (GO:0032205)2.35902633
142cilium assembly (GO:0042384)2.35670348
143ATP-dependent chromatin remodeling (GO:0043044)2.35635660
144ATP biosynthetic process (GO:0006754)2.35528751
145inner mitochondrial membrane organization (GO:0007007)2.34697363
146recombinational repair (GO:0000725)2.34676313
147energy coupled proton transport, down electrochemical gradient (GO:0015985)2.33925001
148ATP synthesis coupled proton transport (GO:0015986)2.33925001
149cell differentiation involved in kidney development (GO:0061005)2.32014754
150single strand break repair (GO:0000012)2.31647697
151transcription from RNA polymerase I promoter (GO:0006360)2.31162606
152transcription initiation from RNA polymerase I promoter (GO:0006361)2.30858483
153proteasome assembly (GO:0043248)2.29977349
154histone H2B ubiquitination (GO:0033523)2.29138211
155regulation of mRNA processing (GO:0050684)2.28906365
156mitotic sister chromatid cohesion (GO:0007064)2.28444894
157RNA-dependent DNA replication (GO:0006278)2.27617801
158limb bud formation (GO:0060174)2.27265124
159viral protein processing (GO:0019082)2.27184240
160appendage development (GO:0048736)2.26789800
161limb development (GO:0060173)2.26789800
162cilium organization (GO:0044782)2.26528751
163establishment of viral latency (GO:0019043)2.26202611
164CTP biosynthetic process (GO:0006241)2.25826454
165CTP metabolic process (GO:0046036)2.25826454
166epithelial cilium movement (GO:0003351)2.25800262
167nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.25180087

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.50006641
2ZNF274_21170338_ChIP-Seq_K562_Hela2.65326896
3GBX2_23144817_ChIP-Seq_PC3_Human2.60510345
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.53289210
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52339357
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.48453879
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.44556469
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.44172391
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.42790554
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42232274
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.40210647
12VDR_22108803_ChIP-Seq_LS180_Human2.37554284
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.35464837
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.33451760
15FUS_26573619_Chip-Seq_HEK293_Human2.33165744
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.32077141
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29609948
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.28713556
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24893200
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.22644429
21TAF15_26573619_Chip-Seq_HEK293_Human2.18730172
22EWS_26573619_Chip-Seq_HEK293_Human2.13097732
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02332116
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00085971
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.95194727
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.94484645
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.90865143
28MYC_18940864_ChIP-ChIP_HL60_Human1.90347407
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.89048955
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86638615
31IGF1R_20145208_ChIP-Seq_DFB_Human1.83497482
32RNF2_27304074_Chip-Seq_NSC_Mouse1.79929440
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78996746
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.77398242
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.77312764
36TTF2_22483619_ChIP-Seq_HELA_Human1.75446703
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72255205
38IRF1_19129219_ChIP-ChIP_H3396_Human1.71469741
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68501423
40EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.68240905
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.67968064
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67595800
43ELK1_19687146_ChIP-ChIP_HELA_Human1.66655701
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.64796492
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64444338
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.63961354
47SUZ12_18555785_Chip-Seq_ESCs_Mouse1.63424929
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62909535
49P300_19829295_ChIP-Seq_ESCs_Human1.58998826
50P53_22387025_ChIP-Seq_ESCs_Mouse1.56104528
51STAT3_18555785_Chip-Seq_ESCs_Mouse1.54512616
52EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.53448093
53EZH2_22144423_ChIP-Seq_EOC_Human1.53256149
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.52926446
55E2F1_18555785_Chip-Seq_ESCs_Mouse1.52764023
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51797490
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51089287
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45344005
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45297658
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44804957
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.44734730
62NMYC_18555785_Chip-Seq_ESCs_Mouse1.43983320
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43205432
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42709766
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.42630797
66P300_18555785_Chip-Seq_ESCs_Mouse1.42474078
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41304503
68ER_23166858_ChIP-Seq_MCF-7_Human1.40465493
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39213705
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.38989210
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36973813
72XRN2_22483619_ChIP-Seq_HELA_Human1.35986430
73RUNX1_27457419_Chip-Seq_LIVER_Mouse1.34771255
74GABP_19822575_ChIP-Seq_HepG2_Human1.34528723
75SOX2_18555785_Chip-Seq_ESCs_Mouse1.33304882
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33236841
77ZFX_18555785_Chip-Seq_ESCs_Mouse1.33192981
78* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32674175
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32549873
80E2F4_17652178_ChIP-ChIP_JURKAT_Human1.31436595
81JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31206972
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30275194
83KLF4_18555785_Chip-Seq_ESCs_Mouse1.28769814
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.27523817
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26559963
86OCT4_18555785_Chip-Seq_ESCs_Mouse1.25971357
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25523498
88DCP1A_22483619_ChIP-Seq_HELA_Human1.24981325
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24487940
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.23181341
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22258684
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21670635
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21075724
94E2F7_22180533_ChIP-Seq_HELA_Human1.20787675
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19765345
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18803281
97FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17151240
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16573021
99* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16302735
100SMAD1_18555785_Chip-Seq_ESCs_Mouse1.15971965
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.14524835
102* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14209141
103* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13409250
104SRF_21415370_ChIP-Seq_HL-1_Mouse1.12734779
105VDR_23849224_ChIP-Seq_CD4+_Human1.12581961
106PU1_27457419_Chip-Seq_LIVER_Mouse1.10213449
107ESRRB_18555785_Chip-Seq_ESCs_Mouse1.09531150
108* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08576145
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08292527
110CTCF_18555785_Chip-Seq_ESCs_Mouse1.07786027
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07253921
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07253921
113EZH2_27304074_Chip-Seq_ESCs_Mouse1.06506751
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05845027
115REST_21632747_ChIP-Seq_MESCs_Mouse1.05692642
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05383529
117SMAD3_21741376_ChIP-Seq_EPCs_Human1.05271543
118FOXP3_21729870_ChIP-Seq_TREG_Human1.05211669
119TP53_22573176_ChIP-Seq_HFKS_Human1.05165187
120CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03774322
121* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03110383
122YY1_21170310_ChIP-Seq_MESCs_Mouse1.02746870
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02300120
124FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01553117
125SMAD4_21799915_ChIP-Seq_A2780_Human1.00760930
126ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99768964
127NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99208086
128MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99018457
129POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99012372
130EED_16625203_ChIP-ChIP_MESCs_Mouse0.98898792
131KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98739787
132CRX_20693478_ChIP-Seq_RETINA_Mouse0.98225281
133HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98080644
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97541094
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96957598
136JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96462089
137RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95994133
138GATA1_26923725_Chip-Seq_HPCs_Mouse0.91689194
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91571656
140UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91428905
141SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88424311
142KDM5A_27292631_Chip-Seq_BREAST_Human0.83836957
143NOTCH1_21737748_ChIP-Seq_TLL_Human0.83718003
144KLF5_20875108_ChIP-Seq_MESCs_Mouse0.80904609
145CBP_20019798_ChIP-Seq_JUKART_Human0.79887382
146IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79887382

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.08886301
2MP0001986_abnormal_taste_sensitivity3.45398809
3MP0001188_hyperpigmentation3.15679029
4MP0009379_abnormal_foot_pigmentation3.01062274
5MP0008057_abnormal_DNA_replication2.95554806
6MP0005423_abnormal_somatic_nervous2.77170354
7MP0003787_abnormal_imprinting2.69723021
8MP0006072_abnormal_retinal_apoptosis2.56440107
9MP0003136_yellow_coat_color2.38582594
10MP0001529_abnormal_vocalization2.35668477
11MP0005646_abnormal_pituitary_gland2.32547113
12MP0005409_darkened_coat_color2.14328595
13MP0000566_synostosis2.01935345
14MP0005551_abnormal_eye_electrophysiolog2.00660603
15MP0002277_abnormal_respiratory_mucosa2.00383233
16MP0002638_abnormal_pupillary_reflex1.94095674
17MP0010386_abnormal_urinary_bladder1.93065718
18MP0005171_absent_coat_pigmentation1.91755752
19MP0005253_abnormal_eye_physiology1.91081085
20MP0005379_endocrine/exocrine_gland_phen1.86649191
21MP0000015_abnormal_ear_pigmentation1.86600708
22MP0003718_maternal_effect1.84129074
23MP0005645_abnormal_hypothalamus_physiol1.83353099
24MP0001293_anophthalmia1.82788285
25MP0002163_abnormal_gland_morphology1.69624161
26MP0008058_abnormal_DNA_repair1.67705389
27MP0003941_abnormal_skin_development1.63237520
28MP0003121_genomic_imprinting1.61486554
29MP0001905_abnormal_dopamine_level1.57336878
30MP0002102_abnormal_ear_morphology1.53307102
31MP0003890_abnormal_embryonic-extraembry1.51647727
32MP0003880_abnormal_central_pattern1.51610311
33MP0002735_abnormal_chemical_nociception1.50495222
34MP0000631_abnormal_neuroendocrine_gland1.49793532
35MP0003693_abnormal_embryo_hatching1.49289490
36MP0004957_abnormal_blastocyst_morpholog1.49255735
37MP0002876_abnormal_thyroid_physiology1.47666162
38MP0002938_white_spotting1.45376251
39MP0008932_abnormal_embryonic_tissue1.43275133
40MP0003123_paternal_imprinting1.40619012
41MP0008877_abnormal_DNA_methylation1.37798580
42MP0002837_dystrophic_cardiac_calcinosis1.37499914
43MP0010030_abnormal_orbit_morphology1.37165360
44MP0003122_maternal_imprinting1.36976563
45MP0005075_abnormal_melanosome_morpholog1.33415469
46MP0000372_irregular_coat_pigmentation1.32215844
47MP0002653_abnormal_ependyma_morphology1.31535982
48MP0009046_muscle_twitch1.29709314
49MP0003646_muscle_fatigue1.29388048
50MP0010094_abnormal_chromosome_stability1.26040863
51MP0001486_abnormal_startle_reflex1.25661604
52MP0003119_abnormal_digestive_system1.24140313
53MP0002095_abnormal_skin_pigmentation1.22227612
54MP0004742_abnormal_vestibular_system1.22037904
55MP0002210_abnormal_sex_determination1.21427611
56MP0004381_abnormal_hair_follicle1.19161631
57MP0004043_abnormal_pH_regulation1.19077703
58MP0000049_abnormal_middle_ear1.17694852
59MP0002132_abnormal_respiratory_system1.16610935
60MP0002751_abnormal_autonomic_nervous1.16130688
61MP0008260_abnormal_autophagy1.16037156
62MP0006276_abnormal_autonomic_nervous1.15569416
63MP0000778_abnormal_nervous_system1.14060120
64MP0004885_abnormal_endolymph1.12916909
65MP0003950_abnormal_plasma_membrane1.12379539
66MP0002234_abnormal_pharynx_morphology1.11243404
67MP0006035_abnormal_mitochondrial_morpho1.11051077
68MP0004142_abnormal_muscle_tone1.10150499
69MP0003861_abnormal_nervous_system1.08460718
70MP0000678_abnormal_parathyroid_gland1.06934353
71MP0002177_abnormal_outer_ear1.06377659
72MP0009697_abnormal_copulation1.06191940
73MP0000026_abnormal_inner_ear1.05949840
74MP0003186_abnormal_redox_activity1.04199770
75MP0001968_abnormal_touch/_nociception1.04085168
76MP0002184_abnormal_innervation1.03940038
77MP0002233_abnormal_nose_morphology1.02882398
78MP0005174_abnormal_tail_pigmentation1.02664761
79MP0000955_abnormal_spinal_cord0.99624475
80MP0004782_abnormal_surfactant_physiolog0.99153557
81MP0003938_abnormal_ear_development0.98896809
82MP0002734_abnormal_mechanical_nocicepti0.98770815
83MP0005499_abnormal_olfactory_system0.98444982
84MP0005394_taste/olfaction_phenotype0.98444982
85MP0002160_abnormal_reproductive_system0.98231270
86MP0001963_abnormal_hearing_physiology0.97759520
87MP0004147_increased_porphyrin_level0.97530721
88MP0001346_abnormal_lacrimal_gland0.96391692
89MP0003567_abnormal_fetal_cardiomyocyte0.95288313
90MP0000613_abnormal_salivary_gland0.95264921
91MP0008789_abnormal_olfactory_epithelium0.94815039
92MP0003011_delayed_dark_adaptation0.94650778
93MP0008872_abnormal_physiological_respon0.94637450
94MP0000569_abnormal_digit_pigmentation0.94553480
95MP0002752_abnormal_somatic_nervous0.94110074
96MP0003315_abnormal_perineum_morphology0.94061814
97MP0003937_abnormal_limbs/digits/tail_de0.92909855
98MP0003786_premature_aging0.92678596
99MP0002822_catalepsy0.92296165
100MP0002272_abnormal_nervous_system0.92184929
101MP0003111_abnormal_nucleus_morphology0.91750355
102MP0001929_abnormal_gametogenesis0.91502786
103MP0005391_vision/eye_phenotype0.88892000
104MP0005195_abnormal_posterior_eye0.88312780
105MP0002067_abnormal_sensory_capabilities0.88228390
106MP0001145_abnormal_male_reproductive0.87222421
107MP0001485_abnormal_pinna_reflex0.86354767
108MP0000681_abnormal_thyroid_gland0.86049023
109MP0000653_abnormal_sex_gland0.85989174
110MP0002152_abnormal_brain_morphology0.85351120
111MP0003635_abnormal_synaptic_transmissio0.84922429
112MP0003698_abnormal_male_reproductive0.84848585
113MP0003878_abnormal_ear_physiology0.84676134
114MP0005377_hearing/vestibular/ear_phenot0.84676134
115MP0003283_abnormal_digestive_organ0.83849923
116MP0000538_abnormal_urinary_bladder0.83843410
117MP0008995_early_reproductive_senescence0.83366423
118MP0002733_abnormal_thermal_nociception0.82171008
119MP0003077_abnormal_cell_cycle0.81671311
120MP0002693_abnormal_pancreas_physiology0.81316226
121MP0001286_abnormal_eye_development0.81054301
122MP0005389_reproductive_system_phenotype0.80977321
123MP0001970_abnormal_pain_threshold0.80704911
124MP0004924_abnormal_behavior0.79224701
125MP0005386_behavior/neurological_phenoty0.79224701
126MP0003755_abnormal_palate_morphology0.78528652
127MP0001502_abnormal_circadian_rhythm0.77453834
128MP0001984_abnormal_olfaction0.76172738
129MP0002557_abnormal_social/conspecific_i0.75395068
130MP0005408_hypopigmentation0.75258722
131MP0001324_abnormal_eye_pigmentation0.73910001
132MP0002229_neurodegeneration0.73568798
133MP0001177_atelectasis0.72928085
134MP0002572_abnormal_emotion/affect_behav0.72418047
135MP0004133_heterotaxia0.72058480
136MP0009745_abnormal_behavioral_response0.71601488
137MP0008007_abnormal_cellular_replicative0.69376678
138MP0002736_abnormal_nociception_after0.68336745
139MP0009250_abnormal_appendicular_skeleto0.68204562

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.34859482
2Acute encephalopathy (HP:0006846)3.32554031
3Abnormal hair whorl (HP:0010721)3.29686874
4Abnormal mitochondria in muscle tissue (HP:0008316)3.27431376
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.20503729
6True hermaphroditism (HP:0010459)3.16934493
7Chromsome breakage (HP:0040012)3.13421612
8Aplasia/Hypoplasia of the sternum (HP:0006714)2.95786838
9Absent rod-and cone-mediated responses on ERG (HP:0007688)2.88340846
10Hypothermia (HP:0002045)2.80143131
11Pancreatic fibrosis (HP:0100732)2.79235669
12Volvulus (HP:0002580)2.78177478
13Patellar aplasia (HP:0006443)2.74209875
14Abnormal rod and cone electroretinograms (HP:0008323)2.71760366
15Pancreatic cysts (HP:0001737)2.67378649
16Colon cancer (HP:0003003)2.67078013
17Congenital stationary night blindness (HP:0007642)2.66612022
18Abnormality of the renal collecting system (HP:0004742)2.66274251
19Type I transferrin isoform profile (HP:0003642)2.66016373
20Hepatocellular necrosis (HP:0001404)2.65514245
21Congenital sensorineural hearing impairment (HP:0008527)2.64137078
22Septo-optic dysplasia (HP:0100842)2.62758339
23Macrocytic anemia (HP:0001972)2.61804076
24Medial flaring of the eyebrow (HP:0010747)2.60011368
25Abnormality of cells of the erythroid lineage (HP:0012130)2.59477869
26Aplasia/Hypoplasia of the patella (HP:0006498)2.58067709
27Increased hepatocellular lipid droplets (HP:0006565)2.54739857
28Abnormality of the ileum (HP:0001549)2.49282357
29Breast hypoplasia (HP:0003187)2.43920366
30Renal Fanconi syndrome (HP:0001994)2.42797799
31Duplicated collecting system (HP:0000081)2.41726781
32Hepatic necrosis (HP:0002605)2.41400961
33Myokymia (HP:0002411)2.38657167
34Attenuation of retinal blood vessels (HP:0007843)2.37494067
35Abnormality of the columella (HP:0009929)2.37258824
36Abnormal number of erythroid precursors (HP:0012131)2.36419561
37Cerebral edema (HP:0002181)2.35647578
38Lip pit (HP:0100267)2.34621934
39Abnormal ciliary motility (HP:0012262)2.32154373
40Fibular aplasia (HP:0002990)2.31515213
41Patchy hypopigmentation of hair (HP:0011365)2.30287041
42Type II lissencephaly (HP:0007260)2.27904285
43Molar tooth sign on MRI (HP:0002419)2.27597227
44Abnormality of midbrain morphology (HP:0002418)2.27597227
45Congenital primary aphakia (HP:0007707)2.24128997
46Nephronophthisis (HP:0000090)2.23295212
47Intestinal atresia (HP:0011100)2.21977034
48Nephrogenic diabetes insipidus (HP:0009806)2.21887423
49Gait imbalance (HP:0002141)2.19425074
50Abnormality of the preputium (HP:0100587)2.18860401
51Abnormal respiratory epithelium morphology (HP:0012253)2.17339522
52Abnormal respiratory motile cilium morphology (HP:0005938)2.17339522
53Protruding tongue (HP:0010808)2.17185134
54Absent thumb (HP:0009777)2.14975224
55Renal cortical cysts (HP:0000803)2.14970346
56Nephroblastoma (Wilms tumor) (HP:0002667)2.14155322
57Acute necrotizing encephalopathy (HP:0006965)2.13983733
58Triphalangeal thumb (HP:0001199)2.11213836
59Nasolacrimal duct obstruction (HP:0000579)2.10923275
60Oligodactyly (hands) (HP:0001180)2.09655257
61Sclerocornea (HP:0000647)2.06648753
62Anencephaly (HP:0002323)2.05869971
63Cupped ear (HP:0000378)2.00302165
64Abnormality of the septum pellucidum (HP:0007375)1.99861285
65Lissencephaly (HP:0001339)1.99736883
66Mitochondrial inheritance (HP:0001427)1.99644760
67Dandy-Walker malformation (HP:0001305)1.99008757
6811 pairs of ribs (HP:0000878)1.98402984
69Scrotal hypoplasia (HP:0000046)1.98343194
70Preaxial hand polydactyly (HP:0001177)1.98320539
71Aplasia/Hypoplasia of the tibia (HP:0005772)1.98148712
72Rib fusion (HP:0000902)1.98045653
73Poor coordination (HP:0002370)1.97655333
74Hypoplasia of the fovea (HP:0007750)1.97109280
75Aplasia/Hypoplasia of the fovea (HP:0008060)1.97109280
76Abnormality of renal resorption (HP:0011038)1.96905219
77Abnormality of chromosome stability (HP:0003220)1.96372172
78Abnormality of the renal medulla (HP:0100957)1.95940486
79Abnormality of the lacrimal duct (HP:0011481)1.95868696
80Embryonal renal neoplasm (HP:0011794)1.95725006
81Birth length less than 3rd percentile (HP:0003561)1.95183791
82Hyperventilation (HP:0002883)1.94973826
83Optic nerve hypoplasia (HP:0000609)1.94940480
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94588654
85Abnormality of the nasolacrimal system (HP:0000614)1.93876579
86White forelock (HP:0002211)1.93723553
87Osteomalacia (HP:0002749)1.93223276
88Bile duct proliferation (HP:0001408)1.93187282
89Abnormal biliary tract physiology (HP:0012439)1.93187282
90Retinal dysplasia (HP:0007973)1.92919776
91Supernumerary spleens (HP:0009799)1.92499743
92Tubulointerstitial nephritis (HP:0001970)1.91462451
93Congenital, generalized hypertrichosis (HP:0004540)1.91178979
94Anophthalmia (HP:0000528)1.91091665
95Genital tract atresia (HP:0001827)1.90864876
96Cystic liver disease (HP:0006706)1.89928151
97Stomach cancer (HP:0012126)1.89389466
98Pallor (HP:0000980)1.89361576
99Abnormal number of incisors (HP:0011064)1.89126936
100Optic disc pallor (HP:0000543)1.89080055
101Lipid accumulation in hepatocytes (HP:0006561)1.89059601
102Postaxial foot polydactyly (HP:0001830)1.88962393
103Bony spicule pigmentary retinopathy (HP:0007737)1.88532241
104Aplasia/hypoplasia of the uterus (HP:0008684)1.87900411
105Progressive macrocephaly (HP:0004481)1.87856945
106Decreased central vision (HP:0007663)1.87546467
107Absent septum pellucidum (HP:0001331)1.86139271
108Sloping forehead (HP:0000340)1.85903638
109Vaginal atresia (HP:0000148)1.85609393
110Ectopic kidney (HP:0000086)1.84829034
111Abnormal lung lobation (HP:0002101)1.84691472
112Hyperglycinemia (HP:0002154)1.84559945
113Parakeratosis (HP:0001036)1.84246879
114Diastasis recti (HP:0001540)1.84108574
1153-Methylglutaconic aciduria (HP:0003535)1.83382262
116Broad-based gait (HP:0002136)1.82683145
117Increased serum lactate (HP:0002151)1.82659963
118Aganglionic megacolon (HP:0002251)1.82466072
119Abnormal respiratory motile cilium physiology (HP:0012261)1.81377336
120Abnormality of incisor morphology (HP:0011063)1.81171471
121Thyroid-stimulating hormone excess (HP:0002925)1.80735437
122Duodenal stenosis (HP:0100867)1.80474082
123Small intestinal stenosis (HP:0012848)1.80474082
124Leukodystrophy (HP:0002415)1.80084777
125Chronic hepatic failure (HP:0100626)1.79718165
126Absent radius (HP:0003974)1.78896429
127Male pseudohermaphroditism (HP:0000037)1.78875283
128Abnormality of the axillary hair (HP:0100134)1.77228965
129Abnormality of secondary sexual hair (HP:0009888)1.77228965
130Severe visual impairment (HP:0001141)1.75329695
131Abnormality of the renal cortex (HP:0011035)1.75327230
132Median cleft lip (HP:0000161)1.74785562
133Pendular nystagmus (HP:0012043)1.74111924
134Aplasia/Hypoplasia of the uvula (HP:0010293)1.73759016
135Microretrognathia (HP:0000308)1.73085181
136Exertional dyspnea (HP:0002875)1.72992142
137Renal agenesis (HP:0000104)1.72599818
138Reduced antithrombin III activity (HP:0001976)1.72276088
139Increased CSF lactate (HP:0002490)1.71917954
140Abnormality of the nasal septum (HP:0000419)1.71363861
141Abnormal protein N-linked glycosylation (HP:0012347)1.71084005
142Abnormal protein glycosylation (HP:0012346)1.71084005
143Abnormal glycosylation (HP:0012345)1.71084005
144Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71084005
145Dynein arm defect of respiratory motile cilia (HP:0012255)1.70803551
146Absent/shortened dynein arms (HP:0200106)1.70803551
147Reticulocytopenia (HP:0001896)1.70357340
148Absent forearm bone (HP:0003953)1.69643010
149Aplasia involving forearm bones (HP:0009822)1.69643010
150Meckel diverticulum (HP:0002245)1.69397316
151Abnormality of the duodenum (HP:0002246)1.69079991
152Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68771234
153Abnormality of the carotid arteries (HP:0005344)1.68317089
154Duplication of thumb phalanx (HP:0009942)1.68286788
155Stenosis of the external auditory canal (HP:0000402)1.67183643
156Lactic acidosis (HP:0003128)1.67119818
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.66924290

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B3.19468469
2CASK3.15731452
3STK162.75122675
4MKNK22.56826675
5ZAK2.50994609
6INSRR2.35814520
7VRK22.19815324
8SRPK12.18905651
9BRD42.03208880
10MKNK12.00014350
11NEK11.86048494
12IRAK41.85288808
13VRK11.77520802
14TRIM281.76337735
15MAPK151.64001809
16ERBB31.60019225
17NEK61.58360355
18IRAK31.56729224
19BRSK21.54798050
20CDK31.52931842
21MUSK1.51680543
22TNIK1.50303707
23PASK1.49663095
24NEK21.49207847
25PLK41.47287306
26TAF11.44427557
27PBK1.43700345
28GRK71.42733636
29MAP4K21.42686483
30PRPF4B1.34551608
31ADRBK21.33683022
32TGFBR11.31940189
33YES11.29375972
34PINK11.28765226
35MAPK131.28636214
36MAP3K41.26459365
37BMPR21.23971298
38GRK11.22229164
39PLK31.19768219
40CLK11.18270609
41MINK11.16987033
42MAP3K141.16985885
43WNK41.16864371
44NUAK11.16638102
45CDK81.15739871
46MAP2K71.15217608
47TXK1.13600234
48AKT31.12394770
49NME11.11657204
50PKN11.08483654
51DYRK31.07176797
52PNCK1.06556506
53ACVR1B1.06393160
54OXSR11.03525383
55SIK31.01964203
56UHMK11.01574909
57DAPK20.99664988
58FRK0.98871208
59TEC0.98319397
60BUB10.96859315
61EIF2AK30.95697749
62EIF2AK20.93319351
63STK38L0.92509155
64TTK0.90844855
65TAOK20.90705258
66MST40.89761966
67PRKCG0.88765193
68CCNB10.88545445
69IRAK20.88511878
70BCR0.86930393
71DYRK1A0.85699616
72CDC70.84096189
73NTRK20.81071508
74STK390.80539876
75SGK20.79061273
76CAMK1G0.78870628
77PLK10.78275739
78SGK4940.77582468
79SGK2230.77582468
80IRAK10.76551097
81DYRK20.76326209
82EPHB20.74381421
83ATR0.73962728
84TRPM70.73169847
85CSNK1E0.71845776
86CSNK1G30.71621075
87CAMK1D0.69391806
88CSNK1G20.69187172
89NTRK30.68081646
90WEE10.67931749
91SIK20.67068590
92BRSK10.64677683
93MAPKAPK50.64024904
94EIF2AK10.62149727
95CHEK20.61967746
96CDK190.61578310
97CSNK1G10.60971766
98PAK30.60578792
99CDK70.60243052
100MARK10.59087670
101BCKDK0.58717277
102ATM0.56761768
103TAOK30.56536211
104TLK10.56421606
105AURKB0.56383029
106PIK3CA0.56350421
107STK40.55562303
108TSSK60.55282162
109MAP3K120.55274200
110RPS6KA50.54224752
111EPHA40.52674532
112STK30.51520503
113CSNK1A1L0.51345270
114WNK10.50334126
115CAMK10.49479432
116HIPK20.48702106
117CSNK2A10.48628963
118AURKA0.48098427
119TNK20.48097727
120PRKCE0.48090950
121ADRBK10.47998799
122PRKG10.46842773
123PIK3CG0.45311567
124IKBKB0.44559254
125PRKDC0.43763757
126PLK20.43642328
127CDK10.43241399
128CDK20.42786441
129CAMK2A0.42252805
130CSNK2A20.40646737
131CHEK10.40525000
132CAMKK10.40285777
133WNK30.39747857
134NLK0.37580243
135PRKACB0.36771012
136CSNK1A10.36574914
137RPS6KA40.36285718
138ALK0.35608871
139STK110.33224336
140PRKCI0.31979716

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.28136938
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.64632684
3RNA polymerase_Homo sapiens_hsa030202.57773075
4Phototransduction_Homo sapiens_hsa047442.51457249
5Non-homologous end-joining_Homo sapiens_hsa034502.35165056
6Fanconi anemia pathway_Homo sapiens_hsa034602.28871586
7Oxidative phosphorylation_Homo sapiens_hsa001902.27033701
8Mismatch repair_Homo sapiens_hsa034302.16672586
9Homologous recombination_Homo sapiens_hsa034402.16391797
10Ribosome_Homo sapiens_hsa030102.15740364
11Spliceosome_Homo sapiens_hsa030402.05190808
12Basal transcription factors_Homo sapiens_hsa030222.05148064
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01493667
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97093885
15RNA degradation_Homo sapiens_hsa030181.89130593
16Parkinsons disease_Homo sapiens_hsa050121.77525459
17DNA replication_Homo sapiens_hsa030301.62500465
18Nucleotide excision repair_Homo sapiens_hsa034201.57641915
19Huntingtons disease_Homo sapiens_hsa050161.53710718
20Propanoate metabolism_Homo sapiens_hsa006401.48719010
21Alzheimers disease_Homo sapiens_hsa050101.47994400
22Proteasome_Homo sapiens_hsa030501.47884416
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45188553
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44714467
25Base excision repair_Homo sapiens_hsa034101.42034901
26Pyrimidine metabolism_Homo sapiens_hsa002401.39845749
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37963998
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36267953
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30193564
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28206227
31Selenocompound metabolism_Homo sapiens_hsa004501.28065226
32Arachidonic acid metabolism_Homo sapiens_hsa005901.27552492
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27210028
34Sphingolipid metabolism_Homo sapiens_hsa006001.26750499
35Nicotine addiction_Homo sapiens_hsa050331.26606754
36Butanoate metabolism_Homo sapiens_hsa006501.26287801
37Taste transduction_Homo sapiens_hsa047421.24179244
38Serotonergic synapse_Homo sapiens_hsa047261.21867846
39Purine metabolism_Homo sapiens_hsa002301.21367664
40Folate biosynthesis_Homo sapiens_hsa007901.18440481
41Ether lipid metabolism_Homo sapiens_hsa005651.17482658
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.16426275
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14002362
44Cell cycle_Homo sapiens_hsa041101.10076741
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07757369
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05264938
47* mRNA surveillance pathway_Homo sapiens_hsa030151.03072819
48Fatty acid elongation_Homo sapiens_hsa000620.97465991
49Autoimmune thyroid disease_Homo sapiens_hsa053200.97173684
50Regulation of autophagy_Homo sapiens_hsa041400.94802190
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94323652
52Pyruvate metabolism_Homo sapiens_hsa006200.94077266
53Linoleic acid metabolism_Homo sapiens_hsa005910.93233906
54Sulfur metabolism_Homo sapiens_hsa009200.92797590
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92714013
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90443904
57Basal cell carcinoma_Homo sapiens_hsa052170.89122213
58Type I diabetes mellitus_Homo sapiens_hsa049400.88416297
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87498282
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.86600346
61Hematopoietic cell lineage_Homo sapiens_hsa046400.84724924
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84580709
63* RNA transport_Homo sapiens_hsa030130.84288221
64Morphine addiction_Homo sapiens_hsa050320.80928631
65Oocyte meiosis_Homo sapiens_hsa041140.76112609
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76011333
67Allograft rejection_Homo sapiens_hsa053300.75994275
68Circadian rhythm_Homo sapiens_hsa047100.75643561
69Sulfur relay system_Homo sapiens_hsa041220.74574503
70Collecting duct acid secretion_Homo sapiens_hsa049660.72380066
71Graft-versus-host disease_Homo sapiens_hsa053320.71563461
72Hedgehog signaling pathway_Homo sapiens_hsa043400.71378577
73Cocaine addiction_Homo sapiens_hsa050300.70060755
74Vitamin B6 metabolism_Homo sapiens_hsa007500.69568305
75Nitrogen metabolism_Homo sapiens_hsa009100.67227988
76N-Glycan biosynthesis_Homo sapiens_hsa005100.66510153
77Asthma_Homo sapiens_hsa053100.65204148
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64728297
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64175166
80Rheumatoid arthritis_Homo sapiens_hsa053230.63934499
81Primary immunodeficiency_Homo sapiens_hsa053400.63866530
82Steroid biosynthesis_Homo sapiens_hsa001000.63816731
83GABAergic synapse_Homo sapiens_hsa047270.61396063
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.58530587
85Olfactory transduction_Homo sapiens_hsa047400.57816437
86Glutamatergic synapse_Homo sapiens_hsa047240.56377286
87Insulin secretion_Homo sapiens_hsa049110.55326687
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54797839
89Tryptophan metabolism_Homo sapiens_hsa003800.53964219
90Vibrio cholerae infection_Homo sapiens_hsa051100.53622932
91Long-term depression_Homo sapiens_hsa047300.51881916
92Peroxisome_Homo sapiens_hsa041460.51685119
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51510661
94Other glycan degradation_Homo sapiens_hsa005110.47512338
95Glutathione metabolism_Homo sapiens_hsa004800.45994516
96Alcoholism_Homo sapiens_hsa050340.45958360
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45807163
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45216625
99Chemical carcinogenesis_Homo sapiens_hsa052040.44598586
100Epstein-Barr virus infection_Homo sapiens_hsa051690.43503355
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42829120
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.42782538
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42631064
104Retinol metabolism_Homo sapiens_hsa008300.42148808
105Wnt signaling pathway_Homo sapiens_hsa043100.42063068
106Herpes simplex infection_Homo sapiens_hsa051680.42056909
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41784340
108Hippo signaling pathway_Homo sapiens_hsa043900.41263537
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40866456
110Caffeine metabolism_Homo sapiens_hsa002320.40553708
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40143582
112p53 signaling pathway_Homo sapiens_hsa041150.39528783
113Amphetamine addiction_Homo sapiens_hsa050310.39169281
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39085204
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38095915
116beta-Alanine metabolism_Homo sapiens_hsa004100.36856268
117Metabolic pathways_Homo sapiens_hsa011000.35688393
118Circadian entrainment_Homo sapiens_hsa047130.35151351
119Cholinergic synapse_Homo sapiens_hsa047250.34994465
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34731178
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33801915
122Cardiac muscle contraction_Homo sapiens_hsa042600.33732240
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33337021
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32958340
125Tyrosine metabolism_Homo sapiens_hsa003500.32053130
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.30191380
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29908317
128Axon guidance_Homo sapiens_hsa043600.29370632
129One carbon pool by folate_Homo sapiens_hsa006700.27584442
130Prostate cancer_Homo sapiens_hsa052150.27276689
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26163195
132Arginine and proline metabolism_Homo sapiens_hsa003300.25421051
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24340264
134Dopaminergic synapse_Homo sapiens_hsa047280.23686171
135Vitamin digestion and absorption_Homo sapiens_hsa049770.23432231
136Measles_Homo sapiens_hsa051620.23009448
137Fat digestion and absorption_Homo sapiens_hsa049750.22936201

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