UPK1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Alternative splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1potassium ion homeostasis (GO:0055075)9.77844629
2citrulline metabolic process (GO:0000052)9.40980934
3phosphatidylinositol acyl-chain remodeling (GO:0036149)8.43410576
4peptidyl-arginine modification (GO:0018195)8.21755585
5phosphatidylserine acyl-chain remodeling (GO:0036150)7.98725999
6benzene-containing compound metabolic process (GO:0042537)7.88779546
7phosphatidylglycerol acyl-chain remodeling (GO:0036148)7.62553231
8glutathione derivative metabolic process (GO:1901685)7.58190407
9glutathione derivative biosynthetic process (GO:1901687)7.58190407
10sodium ion homeostasis (GO:0055078)7.03240111
11branching involved in prostate gland morphogenesis (GO:0060442)6.33474223
12thrombin receptor signaling pathway (GO:0070493)6.16579721
13phosphatidylethanolamine acyl-chain remodeling (GO:0036152)6.06685601
14regulation of clathrin-mediated endocytosis (GO:2000369)5.96454133
15lipoxygenase pathway (GO:0019372)5.85803456
16parturition (GO:0007567)5.84778063
17tonic smooth muscle contraction (GO:0014820)5.58500816
18aggressive behavior (GO:0002118)5.50558041
19phosphatidylcholine acyl-chain remodeling (GO:0036151)5.42109510
20phosphatidylserine metabolic process (GO:0006658)5.39140749
21cellular response to osmotic stress (GO:0071470)5.35344226
22extracellular matrix assembly (GO:0085029)5.34413703
23spindle assembly involved in mitosis (GO:0090307)5.04281589
24establishment of apical/basal cell polarity (GO:0035089)4.98901090
25acrosome reaction (GO:0007340)4.91676265
26intestinal epithelial cell development (GO:0060576)4.86130748
27alditol phosphate metabolic process (GO:0052646)4.80129404
28cyclooxygenase pathway (GO:0019371)4.76519577
29prostate gland epithelium morphogenesis (GO:0060740)4.75495851
30epithelial cell differentiation involved in prostate gland development (GO:0060742)4.75487074
31response to phenylpropanoid (GO:0080184)4.73452075
32galactose catabolic process (GO:0019388)4.68831758
33protein autoprocessing (GO:0016540)4.66229960
34negative regulation of cardiac muscle hypertrophy (GO:0010614)4.65538876
35negative regulation of cardiac muscle tissue growth (GO:0055022)4.62752191
36negative regulation of heart growth (GO:0061117)4.62752191
37glutathione metabolic process (GO:0006749)4.61770222
38anterior/posterior axis specification, embryo (GO:0008595)4.61419927
39lung lobe morphogenesis (GO:0060463)4.51437763
40prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.46584011
41cellular glucuronidation (GO:0052695)4.36470393
42glucuronate metabolic process (GO:0019585)4.28065851
43uronic acid metabolic process (GO:0006063)4.28065851
44establishment or maintenance of monopolar cell polarity (GO:0061339)4.22155990
45establishment of monopolar cell polarity (GO:0061162)4.22155990
46lung vasculature development (GO:0060426)4.19179466
47polarized epithelial cell differentiation (GO:0030859)4.18218593
48phosphatidic acid biosynthetic process (GO:0006654)4.12567825
49phosphatidic acid metabolic process (GO:0046473)4.12567825
50establishment of planar polarity (GO:0001736)4.09262731
51establishment of tissue polarity (GO:0007164)4.09262731
52smooth muscle contraction (GO:0006939)4.04550560
53negative regulation of muscle hypertrophy (GO:0014741)4.04312386
54diol metabolic process (GO:0034311)4.02800853
55keratinization (GO:0031424)4.01957533
56sphingosine metabolic process (GO:0006670)4.01740921
57ovulation cycle (GO:0042698)4.01052450
58artery development (GO:0060840)4.00730960
59response to water (GO:0009415)3.99866796
60platelet aggregation (GO:0070527)3.99682528
61ectoderm development (GO:0007398)3.88394452
62mesonephros development (GO:0001823)3.88317725
63DNA integration (GO:0015074)3.87112702
64microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.73209438
65negative regulation of glycoprotein biosynthetic process (GO:0010561)3.71828232
66regulation of protein glycosylation (GO:0060049)3.71456622
67mRNA transcription from RNA polymerase II promoter (GO:0042789)3.67488952
68water transport (GO:0006833)3.67186811
69endocardial cushion development (GO:0003197)3.66666943
70prostanoid metabolic process (GO:0006692)3.65292294
71prostaglandin metabolic process (GO:0006693)3.65292294
72negative regulation of kidney development (GO:0090185)3.64125887
73protein localization to cell surface (GO:0034394)3.62914904
74response to UV-B (GO:0010224)3.62098441
75UDP-N-acetylglucosamine metabolic process (GO:0006047)3.61432967
76ovulation (GO:0030728)3.56499235
77L-ascorbic acid metabolic process (GO:0019852)3.53611581
78respiratory tube development (GO:0030323)3.53201597
79relaxation of smooth muscle (GO:0044557)3.51992430
80establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.51646111
81cellular ketone body metabolic process (GO:0046950)3.48028966
82ectodermal placode formation (GO:0060788)3.48025538
83lung morphogenesis (GO:0060425)3.44391636
84positive regulation of bone resorption (GO:0045780)3.42082894
85positive regulation of bone remodeling (GO:0046852)3.42082894
86planar cell polarity pathway involved in neural tube closure (GO:0090179)3.40576264
87mRNA transcription (GO:0009299)3.40102805
88sphingoid metabolic process (GO:0046519)3.39048264
89phosphatidylglycerol metabolic process (GO:0046471)3.38691474
90regulation of ruffle assembly (GO:1900027)3.30746733
91vascular smooth muscle contraction (GO:0014829)3.28542579
92establishment or maintenance of bipolar cell polarity (GO:0061245)3.22477898
93establishment or maintenance of apical/basal cell polarity (GO:0035088)3.22477898
94cell volume homeostasis (GO:0006884)3.22354114
95regulation of acrosome reaction (GO:0060046)3.20518239
96glutathione biosynthetic process (GO:0006750)3.20283697
97negative regulation of receptor-mediated endocytosis (GO:0048261)3.19915884
98establishment of skin barrier (GO:0061436)3.18348480
99multicellular organismal water homeostasis (GO:0050891)3.17707848
100regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.14007023
101fluid transport (GO:0042044)3.13099795
102regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.11485800
103regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.11354334
104negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.08243986
105cardiac muscle cell development (GO:0055013)3.06747915
106regulation of plasminogen activation (GO:0010755)3.06478077
107nonribosomal peptide biosynthetic process (GO:0019184)3.06137977
108regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.04900310
109positive regulation of SMAD protein import into nucleus (GO:0060391)3.04795045
110COPI coating of Golgi vesicle (GO:0048205)3.03367564
111Golgi transport vesicle coating (GO:0048200)3.03367564
112primary alcohol catabolic process (GO:0034310)3.02933694
113ketone body metabolic process (GO:1902224)3.01110694
114cGMP-mediated signaling (GO:0019934)2.99126625
115epithelial cell maturation (GO:0002070)2.97398248
116endothelial cell morphogenesis (GO:0001886)2.97188515
117cellular modified amino acid biosynthetic process (GO:0042398)2.93965314
118vasoconstriction (GO:0042310)2.92924729
119fibroblast migration (GO:0010761)2.92787562
120regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.92765594
121cardiac right ventricle morphogenesis (GO:0003215)2.91773277
122epithelial cell-cell adhesion (GO:0090136)2.91769050
123replicative senescence (GO:0090399)2.91579181
124regulation of water loss via skin (GO:0033561)2.89978726
125phosphatidylcholine metabolic process (GO:0046470)2.87210368
126sulfur amino acid catabolic process (GO:0000098)2.86418042
127early endosome to late endosome transport (GO:0045022)2.86285363
128cardiac cell development (GO:0055006)2.83470078
129desmosome organization (GO:0002934)2.82723085
130branching involved in mammary gland duct morphogenesis (GO:0060444)2.82153792
131water homeostasis (GO:0030104)2.81622896
132nodal signaling pathway (GO:0038092)2.81383407
133monovalent inorganic cation homeostasis (GO:0055067)2.79477936
134negative regulation of cardiac muscle tissue development (GO:0055026)2.79372113
135regulation of SMAD protein import into nucleus (GO:0060390)2.79267359
136proline biosynthetic process (GO:0006561)2.78379746
137regulation of Cdc42 GTPase activity (GO:0043088)2.78240674
138homotypic cell-cell adhesion (GO:0034109)2.78025715
139protein retention in ER lumen (GO:0006621)2.77082206
140negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.76519635
141eyelid development in camera-type eye (GO:0061029)2.76363859
142angiotensin maturation (GO:0002003)2.75918885
143purinergic nucleotide receptor signaling pathway (GO:0035590)2.75639205
144response to testosterone (GO:0033574)2.74226421
145regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.73902904
146male genitalia development (GO:0030539)2.73570825
147maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73138081
148negative regulation of catenin import into nucleus (GO:0035414)2.72411846
149beta-amyloid metabolic process (GO:0050435)2.72298631
150regulation of cardiac muscle hypertrophy (GO:0010611)2.71703186
151midgut development (GO:0007494)2.71147642
152fusion of sperm to egg plasma membrane (GO:0007342)2.65964115
153regulation of skeletal muscle contraction (GO:0014819)2.64437985
154coenzyme catabolic process (GO:0009109)2.62922871
155negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.58813262
156cellular modified amino acid metabolic process (GO:0006575)2.58280712
157branched-chain amino acid catabolic process (GO:0009083)2.40540099
158lung epithelium development (GO:0060428)2.33645794
159regulation of dopamine secretion (GO:0014059)2.31087284
160face development (GO:0060324)2.26059062
161response to redox state (GO:0051775)2.25406517
162ethanolamine-containing compound metabolic process (GO:0042439)2.21892333
163keratinocyte differentiation (GO:0030216)2.20752361
164peptide biosynthetic process (GO:0043043)2.19948807
165transepithelial transport (GO:0070633)2.18355310
166negative regulation of transcription regulatory region DNA binding (GO:2000678)2.16196022
167positive regulation of hormone metabolic process (GO:0032352)2.15564574
168peptide metabolic process (GO:0006518)2.12284732
169regulation of mesoderm development (GO:2000380)2.12032144
170cellular modified amino acid catabolic process (GO:0042219)2.11443557
171negative regulation of transcription by competitive promoter binding (GO:0010944)2.10653527
172regulation of interleukin-13 production (GO:0032656)2.09851301
173xenobiotic metabolic process (GO:0006805)2.09798906
174cochlea development (GO:0090102)2.08530427
175positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.08226990
176one-carbon compound transport (GO:0019755)17.0516067
177response to nitrosative stress (GO:0051409)17.0130970
178xenobiotic catabolic process (GO:0042178)16.7166546
179citrulline biosynthetic process (GO:0019240)14.8751462
180hypotonic response (GO:0006971)10.8325700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.79116156
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.42806487
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.42806487
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.42806487
5POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.11269842
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.79519539
7CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.77543040
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.76143729
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.71160233
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.64537572
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.56498433
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.50827901
13TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.50075567
14CLOCK_20551151_ChIP-Seq_293T_Human2.33394758
15CDX2_20551321_ChIP-Seq_CACO-2_Human2.27924552
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.23355711
17TCF3_18692474_ChIP-Seq_MEFs_Mouse2.16935460
18ZNF274_21170338_ChIP-Seq_K562_Hela2.16116930
19PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.15422457
20RACK7_27058665_Chip-Seq_MCF-7_Human2.09466284
21SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.05911688
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.05765799
23ZNF263_19887448_ChIP-Seq_K562_Human2.04578760
24SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.02399540
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.01672868
26IRF1_19129219_ChIP-ChIP_H3396_Human1.96277578
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.95384061
28ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.86292538
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.85094885
30NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.83973581
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82454642
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.82447775
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79798420
34RBPJ_21746931_ChIP-Seq_IB4_Human1.78114458
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.76989161
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.76733975
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74033885
38LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73245055
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.73141324
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73074509
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71397688
42CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.70435364
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.68425389
44* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.65219347
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.64888001
46GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.63922730
47FOXH1_21741376_ChIP-Seq_ESCs_Human1.63311844
48NANOG_18692474_ChIP-Seq_MEFs_Mouse1.63238143
49SOX2_20726797_ChIP-Seq_SW620_Human1.60357874
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.57372174
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55550393
52NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.55166024
53RUNX1_27514584_Chip-Seq_MCF-7_Human1.53973553
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53035180
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52160386
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52056017
57SOX2_18692474_ChIP-Seq_MEFs_Mouse1.48370451
58AHR_22903824_ChIP-Seq_MCF-7_Human1.48265470
59PHF8_20622853_ChIP-Seq_HELA_Human1.47618764
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.46990550
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46946600
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46439348
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44821004
64GATA4_25053715_ChIP-Seq_YYC3_Human1.43730855
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42845787
66* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.42224463
67CTCF_27219007_Chip-Seq_Bcells_Human1.42059964
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.39967014
69GATA6_25053715_ChIP-Seq_YYC3_Human1.39680902
70LXR_22292898_ChIP-Seq_THP-1_Human1.38501782
71TCF4_22108803_ChIP-Seq_LS180_Human1.38419567
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37617463
73ETV1_20927104_ChIP-Seq_GIST48_Human1.37407500
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37214265
75NANOG_20526341_ChIP-Seq_ESCs_Human1.37091748
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36538673
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36422021
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.36103898
79TCF4_18268006_ChIP-ChIP_LS174T_Human1.32719762
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32643712
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.32170910
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32170910
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31992641
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31767942
85CBX2_22325352_ChIP-Seq_293T-Rex_Human1.28673093
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28111849
87TBL1_22424771_ChIP-Seq_293T_Human1.28075987
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27771408
89GATA6_21074721_ChIP-Seq_CACO-2_Human1.26205302
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26131229
91PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.25118820
92P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24625323
93GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.24509884
94* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.22972726
95NFYB_21822215_ChIP-Seq_K562_Human1.22957104
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21426039
97NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21396517
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21336571
99ATF3_27146783_Chip-Seq_COLON_Human1.21205740
100OCT4_18692474_ChIP-Seq_MEFs_Mouse1.21069050
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20276335
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.19362998
103SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19334174
104SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19334174
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18028171
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17906986
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17505591
108CREB1_26743006_Chip-Seq_LNCaP_Human1.15840344
109SA1_27219007_Chip-Seq_Bcells_Human1.14980942
110CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14294957
111FOXO3_23340844_ChIP-Seq_DLD1_Human1.14129497
112EGR1_19374776_ChIP-ChIP_THP-1_Human1.13945913
113KLF5_25053715_ChIP-Seq_YYC3_Human1.12136754
114ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11363916
115EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11155622
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10758131
117TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.10210014
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10012982
119P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.09863128
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09787049
121HNFA_21074721_ChIP-Seq_CACO-2_Human1.09339353
122SMAD3_21741376_ChIP-Seq_HESCs_Human1.08847420
123PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.08444789
124ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07949309
125ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07878630
126CBP_21632823_ChIP-Seq_H3396_Human1.07523805
127RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07435640
128TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07250634
129GATA3_24758297_ChIP-Seq_MCF-7_Human1.06088230
130PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06008781
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.05924076
132DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05449315
133KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05431005
134POU5F1_16518401_ChIP-PET_MESCs_Mouse1.05271011
135RXR_22108803_ChIP-Seq_LS180_Human1.04998455
136SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04304720
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04111089
138HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04078839
139EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03360344
140CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02071950
141* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01648506
142CHD1_26751641_Chip-Seq_LNCaP_Human1.01498968
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01486775
144CDX2_22108803_ChIP-Seq_LS180_Human1.01392953
145KDM2B_26808549_Chip-Seq_K562_Human1.00780117
146MYC_19829295_ChIP-Seq_ESCs_Human1.00778096
147CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00269284
148KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99430196
149EST1_17652178_ChIP-ChIP_JURKAT_Human0.99297105
150HOXB7_26014856_ChIP-Seq_BT474_Human0.99277727
151ELF5_23300383_ChIP-Seq_T47D_Human0.99028361
152TP63_22573176_ChIP-Seq_HFKS_Human0.99013571
153FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.98899202
154E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98375712
155ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98156315
156* KAP1_27257070_Chip-Seq_ESCs_Mouse0.97788529
157NFYA_21822215_ChIP-Seq_K562_Human0.97141720
158AR_20517297_ChIP-Seq_VCAP_Human0.96670905
159GABP_17652178_ChIP-ChIP_JURKAT_Human0.96469528
160RUNX2_22187159_ChIP-Seq_PCA_Human0.92676799
161SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91862355
162SMAD4_21741376_ChIP-Seq_HESCs_Human0.90421432
163AR_25329375_ChIP-Seq_VCAP_Human0.89422491
164FOXA1_25552417_ChIP-Seq_VCAP_Human0.88406952

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000534_abnormal_ureter_morphology4.08177015
2MP0001756_abnormal_urination3.18240983
3MP0000566_synostosis2.53589350
4MP0000516_abnormal_urinary_system10.6348720
5MP0005367_renal/urinary_system_phenotyp10.6348720
6MP0010386_abnormal_urinary_bladder10.0464659
7MP0008872_abnormal_physiological_respon1.97719375
8MP0003878_abnormal_ear_physiology1.65213266
9MP0005377_hearing/vestibular/ear_phenot1.65213266
10MP0000462_abnormal_digestive_system1.62093510
11MP0000537_abnormal_urethra_morphology1.61847460
12MP0005275_abnormal_skin_tensile1.55998987
13MP0001664_abnormal_digestion1.48718092
14MP0006054_spinal_hemorrhage1.47435448
15MP0010234_abnormal_vibrissa_follicle1.36751032
16MP0001905_abnormal_dopamine_level1.36688699
17MP0000538_abnormal_urinary_bladder1.35525657
18MP0008438_abnormal_cutaneous_collagen1.29597856
19MP0001958_emphysema1.28260253
20MP0004264_abnormal_extraembryonic_tissu1.23688975
21MP0003566_abnormal_cell_adhesion1.20141096
22MP0003705_abnormal_hypodermis_morpholog1.12539509
23MP0003283_abnormal_digestive_organ1.08424645
24MP0003011_delayed_dark_adaptation1.05805882
25MP0004185_abnormal_adipocyte_glucose1.05129401
26MP0009643_abnormal_urine_homeostasis1.04006523
27MP0000013_abnormal_adipose_tissue1.03596575
28MP0002837_dystrophic_cardiac_calcinosis1.02856104
29MP0009780_abnormal_chondrocyte_physiolo1.02629870
30MP0008789_abnormal_olfactory_epithelium1.00516709
31MP0010352_gastrointestinal_tract_polyps1.00413315
32MP0005330_cardiomyopathy1.00056338
33MP0004036_abnormal_muscle_relaxation1.00045444
34MP0003315_abnormal_perineum_morphology0.97999085
35MP0005636_abnormal_mineral_homeostasis0.93202698
36MP0000230_abnormal_systemic_arterial0.93074467
37MP0005365_abnormal_bile_salt0.92149153
38MP0004019_abnormal_vitamin_homeostasis0.90937046
39MP0003890_abnormal_embryonic-extraembry0.87251565
40MP0002254_reproductive_system_inflammat0.86430929
41MP0002796_impaired_skin_barrier0.83223782
42MP0009053_abnormal_anal_canal0.83166636
43MP0000613_abnormal_salivary_gland0.80826680
44MP0006292_abnormal_olfactory_placode0.80775616
45MP0000647_abnormal_sebaceous_gland0.80032482
46MP0005620_abnormal_muscle_contractility0.78831799
47MP0010678_abnormal_skin_adnexa0.78116954
48MP0002166_altered_tumor_susceptibility0.77472867
49MP0004133_heterotaxia0.76453220
50MP0000383_abnormal_hair_follicle0.74399077
51MP0005394_taste/olfaction_phenotype0.74324330
52MP0005499_abnormal_olfactory_system0.74324330
53MP0005310_abnormal_salivary_gland0.73412948
54MP0004043_abnormal_pH_regulation0.72355894
55MP0002136_abnormal_kidney_physiology0.71820945
56MP0005332_abnormal_amino_acid0.70561954
57MP0008004_abnormal_stomach_pH0.69954529
58MP0002277_abnormal_respiratory_mucosa0.68919111
59MP0001216_abnormal_epidermal_layer0.67570354
60MP0002098_abnormal_vibrissa_morphology0.67078668
61MP0005023_abnormal_wound_healing0.66504953
62MP0002736_abnormal_nociception_after0.66090504
63MP0004885_abnormal_endolymph0.65594458
64MP0005670_abnormal_white_adipose0.65266698
65MP0005503_abnormal_tendon_morphology0.64703315
66MP0005646_abnormal_pituitary_gland0.64661720
67MP0005381_digestive/alimentary_phenotyp0.63592183
68MP0000465_gastrointestinal_hemorrhage0.62007749
69MP0005187_abnormal_penis_morphology0.61597594
70MP0000427_abnormal_hair_cycle0.60202266
71MP0001270_distended_abdomen0.57465755
72MP0004272_abnormal_basement_membrane0.57252141
73MP0001485_abnormal_pinna_reflex0.57028119
74MP0002249_abnormal_larynx_morphology0.56884739
75MP0003638_abnormal_response/metabolism_0.55847322
76MP0010030_abnormal_orbit_morphology0.55833908
77MP0003941_abnormal_skin_development0.55785946
78MP0000750_abnormal_muscle_regeneration0.55638609
79MP0002135_abnormal_kidney_morphology0.55594300
80MP0004381_abnormal_hair_follicle0.54664148
81MP0000751_myopathy0.53610601
82MP0010771_integument_phenotype0.53540940
83MP0005319_abnormal_enzyme/_coenzyme0.52978005
84MP0006138_congestive_heart_failure0.52045159
85MP0003942_abnormal_urinary_system0.51887813
86MP0003385_abnormal_body_wall0.51783757
87MP0002006_tumorigenesis0.51518728
88MP0002102_abnormal_ear_morphology0.51290062
89MP0003136_yellow_coat_color0.50704468
90MP0004084_abnormal_cardiac_muscle0.50166322
91MP0005410_abnormal_fertilization0.50079287
92MP0005083_abnormal_biliary_tract0.50030861
93MP0005595_abnormal_vascular_smooth0.50025274
94MP0000377_abnormal_hair_follicle0.48602960
95MP0005084_abnormal_gallbladder_morpholo0.48211482
96MP0002653_abnormal_ependyma_morphology0.47523431
97MP0004858_abnormal_nervous_system0.46454298
98MP0008877_abnormal_DNA_methylation0.46228478
99MP0003938_abnormal_ear_development0.44278821
100MP0009379_abnormal_foot_pigmentation0.44152388
101MP0002909_abnormal_adrenal_gland0.43020970
102MP0000163_abnormal_cartilage_morphology0.42999452
103MP0002089_abnormal_postnatal_growth/wei0.42033289
104MP0000003_abnormal_adipose_tissue0.41998362
105MP0003453_abnormal_keratinocyte_physiol0.41870411
106MP0000858_altered_metastatic_potential0.40932766
107MP0001984_abnormal_olfaction0.39863407
108MP0001502_abnormal_circadian_rhythm0.39680902
109MP0005551_abnormal_eye_electrophysiolog0.39513247
110MP0000470_abnormal_stomach_morphology0.39208840
111MP0005647_abnormal_sex_gland0.38376495
112MP0003937_abnormal_limbs/digits/tail_de0.38341658
113MP0005166_decreased_susceptibility_to0.38155484
114MP0001765_abnormal_ion_homeostasis0.38057860
115MP0000477_abnormal_intestine_morphology0.38001403
116MP0005164_abnormal_response_to0.36981890
117MP0003567_abnormal_fetal_cardiomyocyte0.36832398
118MP0002938_white_spotting0.36515109
119MP0000579_abnormal_nail_morphology0.36379488
120MP0008875_abnormal_xenobiotic_pharmacok0.35836872
121MP0005375_adipose_tissue_phenotype0.35001622
122MP0000762_abnormal_tongue_morphology0.34824522
123MP0004147_increased_porphyrin_level0.34421185
124MP0002233_abnormal_nose_morphology0.34087024
125MP0001873_stomach_inflammation0.33915248
126MP0004130_abnormal_muscle_cell0.32796860
127MP0001666_abnormal_nutrient_absorption0.32550966
128MP0005666_abnormal_adipose_tissue0.32358516
129MP0002282_abnormal_trachea_morphology0.32354055
130MP0001849_ear_inflammation0.32128714
131MP0002557_abnormal_social/conspecific_i0.32000491
132MP0009384_cardiac_valve_regurgitation0.31702376
133MP0005501_abnormal_skin_physiology0.31692088
134MP0000350_abnormal_cell_proliferation0.30932629
135MP0002822_catalepsy0.30357916
136MP0002127_abnormal_cardiovascular_syste0.29901330
137MP0002114_abnormal_axial_skeleton0.29700729
138MP0002060_abnormal_skin_morphology0.29601801
139MP0002111_abnormal_tail_morphology0.29520778
140MP0010155_abnormal_intestine_physiology0.29305350
141MP0009250_abnormal_appendicular_skeleto0.28542250
142MP0004087_abnormal_muscle_fiber0.28185412
143MP0003300_gastrointestinal_ulcer0.28041446
144MP0000627_abnormal_mammary_gland0.28040420
145MP0002269_muscular_atrophy0.27728696
146MP0003119_abnormal_digestive_system0.27671977
147MP0002092_abnormal_eye_morphology0.27597115
148MP0000767_abnormal_smooth_muscle0.27489253
149MP0002925_abnormal_cardiovascular_devel0.26848581
150MP0003137_abnormal_impulse_conducting0.26526361
151MP0000747_muscle_weakness0.26271611
152MP0003252_abnormal_bile_duct0.26073895
153MP0004197_abnormal_fetal_growth/weight/0.25962033
154MP0003935_abnormal_craniofacial_develop0.25924894
155MP0003936_abnormal_reproductive_system0.25848237
156MP0005076_abnormal_cell_differentiation0.25835091
157MP0003122_maternal_imprinting0.25802387
158MP0001968_abnormal_touch/_nociception0.25586783
159MP0002115_abnormal_skeleton_extremities0.24826680
160MP0001663_abnormal_digestive_system0.24754099
161MP0003045_fibrosis0.24739034
162MP0001346_abnormal_lacrimal_gland0.24468060
163MP0005085_abnormal_gallbladder_physiolo0.24268005
164MP0003186_abnormal_redox_activity0.24231144
165MP0005075_abnormal_melanosome_morpholog0.23945807
166MP0000467_abnormal_esophagus_morphology0.23444846
167MP0010329_abnormal_lipoprotein_level0.23232089
168MP0002733_abnormal_thermal_nociception0.23060049

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)9.65462537
2Aortic dissection (HP:0002647)7.08145481
3Neoplasm of the heart (HP:0100544)6.09257886
4Gastrointestinal dysmotility (HP:0002579)6.08594963
5Malnutrition (HP:0004395)5.62230998
6Long clavicles (HP:0000890)5.59139836
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.54238977
8Ankle contracture (HP:0006466)5.12039466
9Parakeratosis (HP:0001036)5.04213601
10Cerebral aneurysm (HP:0004944)4.99982085
11Hyperactive renin-angiotensin system (HP:0000841)4.93432552
12Eczematoid dermatitis (HP:0000976)4.83986672
13Abnormality of the 2nd finger (HP:0004100)4.72608088
14Abdominal situs inversus (HP:0003363)4.61424336
15Abnormality of abdominal situs (HP:0011620)4.61424336
16Cerebral palsy (HP:0100021)4.60596260
17Short hallux (HP:0010109)4.54510726
18Seborrheic dermatitis (HP:0001051)4.33321417
19Ulnar bowing (HP:0003031)4.29952978
20Aplasia/Hypoplasia of the hallux (HP:0008362)4.25371799
21Congenital ichthyosiform erythroderma (HP:0007431)4.13627653
22Hydroureter (HP:0000072)3.97139224
23Abnormality of the salivary glands (HP:0010286)3.95262922
24Chronic bronchitis (HP:0004469)3.88658979
25Acanthocytosis (HP:0001927)3.86940517
26Increased density of long bones (HP:0006392)3.72910136
27Aortic regurgitation (HP:0001659)3.72767197
28Absent frontal sinuses (HP:0002688)3.71756469
29Stridor (HP:0010307)3.60937101
30Long toe (HP:0010511)3.57659975
31Wrist flexion contracture (HP:0001239)3.53079663
32Abnormal foot bone ossification (HP:0010675)3.47325265
33Selective tooth agenesis (HP:0001592)3.47300200
34Growth hormone excess (HP:0000845)3.42228407
35Abnormality of secondary sexual hair (HP:0009888)3.42136002
36Abnormality of the axillary hair (HP:0100134)3.42136002
37Erythroderma (HP:0001019)3.40743726
38Broad distal phalanx of finger (HP:0009836)3.34677939
39Long foot (HP:0001833)3.27181395
40Palmoplantar hyperkeratosis (HP:0000972)3.27107521
41Renal salt wasting (HP:0000127)3.25718368
42Abnormal pupillary function (HP:0007686)3.25367599
43Decreased circulating renin level (HP:0003351)3.22640725
44Aneurysm (HP:0002617)3.21963517
45Palmar hyperkeratosis (HP:0010765)3.21565367
46Hypokalemic alkalosis (HP:0001949)3.19333428
47Mesomelia (HP:0003027)3.18906510
48Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.17115932
49Short 4th metacarpal (HP:0010044)3.17115932
50Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.15193897
51Hyperaldosteronism (HP:0000859)3.14099642
52Radial bowing (HP:0002986)3.13340366
53Hyperparathyroidism (HP:0000843)3.13237804
54Redundant skin (HP:0001582)3.10460938
55Ureteral stenosis (HP:0000071)3.04972732
56Hyperkalemia (HP:0002153)3.01115564
57Tarsal synostosis (HP:0008368)2.99834352
58Bicuspid aortic valve (HP:0001647)2.97754612
59Broad face (HP:0000283)2.95187534
60Scapular winging (HP:0003691)2.92122572
61Conical tooth (HP:0000698)2.89594735
62Spastic diplegia (HP:0001264)2.85839928
63Dilatation of the ascending aorta (HP:0005111)2.84583047
64Synostosis of carpal bones (HP:0005048)2.84508156
65Genu varum (HP:0002970)2.83996663
66Ureteral obstruction (HP:0006000)2.83603202
67Hyperglycinuria (HP:0003108)2.81937655
68Persistence of primary teeth (HP:0006335)2.79609540
69Breast hypoplasia (HP:0003187)2.76878869
70Abnormality of the calcaneus (HP:0008364)2.73414949
71Synostosis involving bones of the lower limbs (HP:0009138)2.73135092
72Synostosis involving bones of the feet (HP:0009140)2.73135092
73Short humerus (HP:0005792)2.72410065
74Abnormality of renin-angiotensin system (HP:0000847)2.71989241
75Fused cervical vertebrae (HP:0002949)2.69584958
76Carpal synostosis (HP:0009702)2.67744724
77Clubbing of toes (HP:0100760)2.67220666
78Plantar hyperkeratosis (HP:0007556)2.66546431
79Hypoplastic labia majora (HP:0000059)2.62677169
80Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.61684259
81Facial diplegia (HP:0001349)2.60289567
82Testicular atrophy (HP:0000029)2.57121001
83Type 1 muscle fiber predominance (HP:0003803)2.54675733
84Osteolytic defects of the hand bones (HP:0009699)2.54532225
85Osteolytic defects of the phalanges of the hand (HP:0009771)2.54532225
86Bowed forearm bones (HP:0003956)2.54471271
87Bowing of the arm (HP:0006488)2.54471271
88Aplasia/hypoplasia of the humerus (HP:0006507)2.52889288
89Abnormality of chloride homeostasis (HP:0011422)2.51139696
90Thickened calvaria (HP:0002684)2.50831499
91Camptodactyly of toe (HP:0001836)2.50542779
92Labial hypoplasia (HP:0000066)2.49295486
93Shawl scrotum (HP:0000049)2.47861159
94Abnormality of the labia majora (HP:0012881)2.41866654
95Abnormality of cochlea (HP:0000375)2.40322486
96Abnormal ossification of hand bones (HP:0005921)2.39667670
97Elbow flexion contracture (HP:0002987)2.38478669
98Hyponatremia (HP:0002902)2.34232785
99Partial duplication of thumb phalanx (HP:0009944)2.32884289
100Abnormality of the 4th metacarpal (HP:0010012)2.32620106
101Knee flexion contracture (HP:0006380)2.31297923
102Abnormality of the dental root (HP:0006486)2.30986414
103Taurodontia (HP:0000679)2.30986414
104Abnormality of permanent molar morphology (HP:0011071)2.30986414
105Nasolacrimal duct obstruction (HP:0000579)2.29711140
106Abnormality of oral frenula (HP:0000190)2.27653885
107Aplasia involving bones of the upper limbs (HP:0009823)2.26565031
108Aplasia of the phalanges of the hand (HP:0009802)2.26565031
109Aplasia involving bones of the extremities (HP:0009825)2.26565031
110Absent toe (HP:0010760)2.26231362
111Increased mean platelet volume (HP:0011877)2.25588654
112Hypoplastic female external genitalia (HP:0012815)2.25453141
113Abnormality of the right ventricle (HP:0001707)2.24470558
114Broad hallux (HP:0010055)2.24408486
115Limb-girdle muscle atrophy (HP:0003797)2.24317346
116Abnormality of the phalanges of the 2nd finger (HP:0009541)2.21997442
117Focal segmental glomerulosclerosis (HP:0000097)2.21248348
118Glossoptosis (HP:0000162)2.20803159
119Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.20529206
120Amelogenesis imperfecta (HP:0000705)2.19820512
121Aplasia/Hypoplasia of the fibula (HP:0006492)2.19382079
122Blepharitis (HP:0000498)2.15197369
123Abnormality of the dental pulp (HP:0006479)2.14703048
124Intestinal malrotation (HP:0002566)2.13385523
125Abnormality of the lacrimal duct (HP:0011481)2.12917621
126Abnormality of molar morphology (HP:0011070)2.10838298
127Abnormality of molar (HP:0011077)2.10838298
128Tracheal stenosis (HP:0002777)2.10764613
129Broad toe (HP:0001837)2.10752983
130Synostosis involving bones of the hand (HP:0004278)2.10120188
131Absent radius (HP:0003974)2.09676898
132Abnormality of the middle phalanges of the toes (HP:0010183)2.08852187
133Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.06580911
134Septate vagina (HP:0001153)2.06160822
135Anal stenosis (HP:0002025)2.02566560
136Lip pit (HP:0100267)2.00843551
137Aplasia involving forearm bones (HP:0009822)1.99471802
138Absent forearm bone (HP:0003953)1.99471802
139Congenital hip dislocation (HP:0001374)1.99454440
140Microretrognathia (HP:0000308)1.99005771
141Ulnar deviation of finger (HP:0009465)1.98585340
142Median cleft lip (HP:0000161)1.98562968
143Dehydration (HP:0001944)1.98433613
144Joint swelling (HP:0001386)1.98416822
145Tongue fasciculations (HP:0001308)1.98358913
146Widely patent fontanelles and sutures (HP:0004492)1.97834393
147Pancreatic cysts (HP:0001737)1.95911449
148Abnormality of the proximal phalanges of the hand (HP:0009834)1.95055204
149Fibular aplasia (HP:0002990)1.94633556
150Hypoplasia of the uterus (HP:0000013)1.94269549
151Partial duplication of the phalanx of hand (HP:0009999)1.94165607
152Non-midline cleft lip (HP:0100335)1.93988972
153Abnormality of nail color (HP:0100643)1.92752427
154Aplasia/Hypoplasia of the scapulae (HP:0006713)1.92312675
155Hypoplastic scapulae (HP:0000882)1.92312675
156Short chin (HP:0000331)1.91967284
157Abnormal platelet volume (HP:0011876)1.91728815
158Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.90097376
159Absent hair (HP:0002298)1.89958101
160Right ventricular cardiomyopathy (HP:0011663)1.88892797
161Hyperpituitarism (HP:0010514)1.88733873
162Midline defect of the nose (HP:0004122)1.87007833
163Abnormality of sodium homeostasis (HP:0010931)1.86977773
164Abnormality of the frontal sinuses (HP:0002687)1.86894780
165Concave nail (HP:0001598)1.86310999
166Abnormality of the gastric mucosa (HP:0004295)1.85354709
167Hyperuricemia (HP:0002149)1.85191809
168Increased purine levels (HP:0004368)1.85191809
169Abnormality of the shoulder girdle musculature (HP:0001435)1.84942714
170Fibular hypoplasia (HP:0003038)1.84143735
171Absent hand (HP:0004050)1.84026188
172Abnormality of the epiphyses of the hand (HP:0005924)1.82347629
173Hypoplasia of the ulna (HP:0003022)1.81598444
174Glomerulosclerosis (HP:0000096)1.80694601
175Mitral valve prolapse (HP:0001634)1.80435091
176Congenital, generalized hypertrichosis (HP:0004540)1.79604897
177Abnormality of serine family amino acid metabolism (HP:0010894)1.78554489
178Abnormality of glycine metabolism (HP:0010895)1.78554489
179Abnormality of the nasolacrimal system (HP:0000614)1.78456699
180Maternal diabetes (HP:0009800)1.77838434
181Septo-optic dysplasia (HP:0100842)1.77739867
182Abnormality of the labia (HP:0000058)1.74320807
183Pendular nystagmus (HP:0012043)1.74060365
184Oligodactyly (hands) (HP:0001180)1.72523025
185Neoplasm of the lung (HP:0100526)1.72352101
186Pancreatic fibrosis (HP:0100732)1.70416116
187Popliteal pterygium (HP:0009756)1.69819371
188Cupped ear (HP:0000378)1.69655306
189Aplasia of the musculature (HP:0100854)1.69179371
190Hypothermia (HP:0002045)1.69003389
191Potter facies (HP:0002009)1.66741779
192Facial shape deformation (HP:0011334)1.66741779
193Furrowed tongue (HP:0000221)1.65445965
194Abnormality of purine metabolism (HP:0004352)1.63334888
195Alkalosis (HP:0001948)1.63286748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN9.41535821
2MYLK8.02979829
3GRK54.27433441
4DMPK3.43887856
5AKT33.10067612
6PIK3CG2.95894937
7LMTK22.57302002
8PAK22.54698348
9NME12.53093158
10MAP3K122.32797999
11EPHA22.04578080
12STK241.98621036
13TGFBR11.96479346
14WNK41.96098390
15STK391.91377470
16DDR21.90763466
17MST1R1.86615659
18ERN11.85283964
19BMPR1B1.79658888
20ACVR1B1.73800113
21MST41.67150971
22STK38L1.65546290
23ZAK1.63843252
24NUAK11.57941065
25PNCK1.42416443
26MAPKAPK31.40990695
27FGFR11.40072174
28STK161.40049729
29PINK11.35025492
30GRK11.33296952
31FGR1.32894309
32EEF2K1.32793551
33WNK31.27822259
34MAP4K21.27550694
35MUSK1.22280669
36CAMK2G1.21642424
37PAK11.20636219
38MINK11.20505579
39TNIK1.19114775
40LATS11.18229456
41MET1.18214838
42RPS6KB21.15345097
43TRIM281.15041539
44CDC42BPA1.13401074
45ILK1.11000443
46OXSR11.10080117
47CASK1.08298587
48NME21.07509199
49DAPK31.07417616
50PIK3CA1.06978665
51RPS6KA21.05307240
52EPHB21.02166834
53RIPK10.99806539
54CDK90.97921629
55MELK0.95906170
56SIK10.95655884
57VRK20.93354180
58MAP2K60.89313932
59MAPKAPK50.87730447
60ADRBK20.85254584
61ROCK20.83202874
62TESK10.81987299
63PHKG20.81578001
64PHKG10.81578001
65PTK20.81166034
66FRK0.80037872
67LRRK20.78546636
68TRIB30.78334334
69RAF10.77391033
70RPS6KC10.76067431
71RPS6KL10.76067431
72BCKDK0.70059727
73TAOK30.68468349
74CDK120.68171902
75STK100.66454494
76MAP3K20.66173386
77INSRR0.65853558
78NEK20.65751492
79ROCK10.65725120
80SCYL20.63279351
81RPS6KA60.60815353
82WEE10.59269952
83FER0.58674464
84CAMK2B0.57595022
85ICK0.57367234
86PRKCE0.57047757
87CDK80.54976312
88TYRO30.54478353
89GSK3A0.54347277
90NLK0.53747594
91BRD40.51667527
92TGFBR20.51112489
93MATK0.50599828
94PDGFRA0.50392350
95IKBKB0.50374701
96MTOR0.50167745
97LATS20.48990922
98WNK10.48903918
99PKN20.47652953
100ERBB40.47301277
101CAMK2D0.46189413
102PAK30.45813740
103FGFR30.44305994
104PRKCI0.44270659
105BCR0.43422154
106MAPKAPK20.43382838
107MKNK20.42459736
108PRKACB0.42298996
109BRSK20.41762033
110SRPK10.41182711
111TTK0.40227960
112NEK10.39995857
113AURKB0.38973527
114PBK0.38894775
115ADRBK10.37705140
116CHUK0.36830598
117CAMK1G0.36646990
118DYRK20.35977228
119CSNK1A10.35200458
120ERBB20.34782906
121CAMK10.34604645
122YES10.33868031
123TAF10.33836064
124PRKCQ0.33055921
125SGK20.32749026
126LIMK10.32637265
127KSR20.31340988
128PRKCZ0.30487127
129STK380.29465815
130PTK60.29147527
131MAPK130.28423830
132TESK20.28079569
133TNK20.27736347
134MAP3K40.27573604
135FYN0.27247615
136SGK30.26941828
137PLK10.25060411
138STK30.24780695
139MAPK40.24059144
140BMX0.22889651
141TRPM70.22123217
142PAK40.21957627
143MAP2K10.21752574
144CSK0.20547469
145MAP3K30.18060609
146RPS6KA10.18022905
147NTRK10.15143506
148MAP3K70.14805910
149TAOK10.14715601
150PRKD20.14509107
151EPHB10.14471827
152DAPK10.12575271
153DAPK20.12428436
154MAP2K30.11800172
155SRC0.11376045
156PRKD10.10322500
157CDK70.10248569
158INSR0.07624969
159PDK30.07457489
160PDK40.07457489
161CAMKK10.07077768
162PDK20.07047396

Predicted pathways (KEGG)

RankGene SetZ-score
1Bladder cancer_Homo sapiens_hsa052196.09828853
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005925.23123142
3Linoleic acid metabolism_Homo sapiens_hsa005914.39135183
4Vascular smooth muscle contraction_Homo sapiens_hsa042704.18767855
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.09340005
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.96362107
7Ether lipid metabolism_Homo sapiens_hsa005652.87345745
8Arachidonic acid metabolism_Homo sapiens_hsa005902.80457614
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.71183533
10Fat digestion and absorption_Homo sapiens_hsa049752.65125368
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.62506769
12Sulfur metabolism_Homo sapiens_hsa009202.22236769
13Focal adhesion_Homo sapiens_hsa045102.19489082
14Tight junction_Homo sapiens_hsa045302.09575573
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06619384
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99725777
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92123969
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88756141
19Hippo signaling pathway_Homo sapiens_hsa043901.88637002
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.87318444
21Proteoglycans in cancer_Homo sapiens_hsa052051.81673528
22Renin-angiotensin system_Homo sapiens_hsa046141.70432404
23TGF-beta signaling pathway_Homo sapiens_hsa043501.70396547
24Other glycan degradation_Homo sapiens_hsa005111.66258365
25ECM-receptor interaction_Homo sapiens_hsa045121.62748740
26Adherens junction_Homo sapiens_hsa045201.58213300
27Chemical carcinogenesis_Homo sapiens_hsa052041.57926907
28Nitrogen metabolism_Homo sapiens_hsa009101.55084592
29Platelet activation_Homo sapiens_hsa046111.53730346
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.51270339
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.49511253
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.48906478
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.37760669
34Basal cell carcinoma_Homo sapiens_hsa052171.36811500
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35422336
36Thyroid cancer_Homo sapiens_hsa052161.35358425
37Glutathione metabolism_Homo sapiens_hsa004801.33328851
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.30055644
39Retinol metabolism_Homo sapiens_hsa008301.29888592
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27395267
41Butanoate metabolism_Homo sapiens_hsa006501.27167851
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26529731
43Oxidative phosphorylation_Homo sapiens_hsa001901.23176854
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.22367599
45Phenylalanine metabolism_Homo sapiens_hsa003601.20627425
46Protein digestion and absorption_Homo sapiens_hsa049741.19610864
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16093292
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.13178423
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11179683
50Oxytocin signaling pathway_Homo sapiens_hsa049211.05978038
51Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05638842
52Protein export_Homo sapiens_hsa030601.04193416
53Gastric acid secretion_Homo sapiens_hsa049711.02154754
54Histidine metabolism_Homo sapiens_hsa003401.01654315
55Amoebiasis_Homo sapiens_hsa051460.99071946
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97901145
57beta-Alanine metabolism_Homo sapiens_hsa004100.96584765
58Biosynthesis of amino acids_Homo sapiens_hsa012300.94511902
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92712560
60Sphingolipid metabolism_Homo sapiens_hsa006000.91909352
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91463901
62Ovarian steroidogenesis_Homo sapiens_hsa049130.91163375
63Dilated cardiomyopathy_Homo sapiens_hsa054140.91074977
64Hedgehog signaling pathway_Homo sapiens_hsa043400.89039271
65Fatty acid elongation_Homo sapiens_hsa000620.84962756
66Parkinsons disease_Homo sapiens_hsa050120.84937686
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84291079
68Phototransduction_Homo sapiens_hsa047440.83833229
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.83482290
70Circadian rhythm_Homo sapiens_hsa047100.82213952
71mTOR signaling pathway_Homo sapiens_hsa041500.80380512
72Arginine and proline metabolism_Homo sapiens_hsa003300.79882165
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79519170
74Vibrio cholerae infection_Homo sapiens_hsa051100.79163535
75Insulin resistance_Homo sapiens_hsa049310.79115118
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78686870
77Fructose and mannose metabolism_Homo sapiens_hsa000510.77296598
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76993212
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76414739
80Thyroid hormone synthesis_Homo sapiens_hsa049180.75283352
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73349622
82Peroxisome_Homo sapiens_hsa041460.73194126
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70929026
84Arginine biosynthesis_Homo sapiens_hsa002200.67736847
85Proteasome_Homo sapiens_hsa030500.67489591
86Sulfur relay system_Homo sapiens_hsa041220.66285689
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65663328
88AMPK signaling pathway_Homo sapiens_hsa041520.64596145
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64403354
90Pancreatic secretion_Homo sapiens_hsa049720.64343193
91Huntingtons disease_Homo sapiens_hsa050160.62572379
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58930554
93Insulin signaling pathway_Homo sapiens_hsa049100.58918970
94Lysosome_Homo sapiens_hsa041420.58610800
95Metabolic pathways_Homo sapiens_hsa011000.58584974
96Basal transcription factors_Homo sapiens_hsa030220.58014305
97Melanogenesis_Homo sapiens_hsa049160.57637663
98Vitamin digestion and absorption_Homo sapiens_hsa049770.55603653
99Wnt signaling pathway_Homo sapiens_hsa043100.54494353
100Fatty acid degradation_Homo sapiens_hsa000710.54429562
101Shigellosis_Homo sapiens_hsa051310.53749055
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53725302
103Selenocompound metabolism_Homo sapiens_hsa004500.52711813
104Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50946024
105MicroRNAs in cancer_Homo sapiens_hsa052060.50740020
106Small cell lung cancer_Homo sapiens_hsa052220.49832027
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48172906
108Lysine degradation_Homo sapiens_hsa003100.47844983
109Carbon metabolism_Homo sapiens_hsa012000.46356324
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46250540
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45730274
112RNA degradation_Homo sapiens_hsa030180.44923856
113One carbon pool by folate_Homo sapiens_hsa006700.44756954
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44474432
115VEGF signaling pathway_Homo sapiens_hsa043700.44417378
116Prostate cancer_Homo sapiens_hsa052150.43251653
117Fatty acid biosynthesis_Homo sapiens_hsa000610.42892322
118Endometrial cancer_Homo sapiens_hsa052130.41292494
119Pathways in cancer_Homo sapiens_hsa052000.41284799
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.40927775
121Notch signaling pathway_Homo sapiens_hsa043300.40802193
122Propanoate metabolism_Homo sapiens_hsa006400.40180327
123Glucagon signaling pathway_Homo sapiens_hsa049220.39599056
124Bile secretion_Homo sapiens_hsa049760.38283511
125Salmonella infection_Homo sapiens_hsa051320.38005221
126Tyrosine metabolism_Homo sapiens_hsa003500.37816421
127RNA polymerase_Homo sapiens_hsa030200.37338572
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37000670
129Collecting duct acid secretion_Homo sapiens_hsa049660.36504999
130Salivary secretion_Homo sapiens_hsa049700.36399971
131Calcium signaling pathway_Homo sapiens_hsa040200.36349350
132Alzheimers disease_Homo sapiens_hsa050100.35878942
133Folate biosynthesis_Homo sapiens_hsa007900.35677834
134Estrogen signaling pathway_Homo sapiens_hsa049150.35644432
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.35026152
136Starch and sucrose metabolism_Homo sapiens_hsa005000.35004208
137Non-homologous end-joining_Homo sapiens_hsa034500.34375999
138Cardiac muscle contraction_Homo sapiens_hsa042600.34303634
139PPAR signaling pathway_Homo sapiens_hsa033200.34173853
140Ribosome_Homo sapiens_hsa030100.33201923
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32786117
142Taste transduction_Homo sapiens_hsa047420.32330835
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32327402
144Homologous recombination_Homo sapiens_hsa034400.32075283
145Tryptophan metabolism_Homo sapiens_hsa003800.31991470
146Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30088056
147Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25824988
148Base excision repair_Homo sapiens_hsa034100.25445710
149Purine metabolism_Homo sapiens_hsa002300.25158674
150Galactose metabolism_Homo sapiens_hsa000520.24515781
151Inositol phosphate metabolism_Homo sapiens_hsa005620.22494800
152Fatty acid metabolism_Homo sapiens_hsa012120.21530409
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21409585
154Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18282356
155Glycerolipid metabolism_Homo sapiens_hsa005610.17916601
156Pyrimidine metabolism_Homo sapiens_hsa002400.14401495
157Ras signaling pathway_Homo sapiens_hsa040140.14376716
158Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14103224
159Primary bile acid biosynthesis_Homo sapiens_hsa001200.13947707

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