UPK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-arginine modification (GO:0018195)9.51012098
2sodium ion homeostasis (GO:0055078)8.13424669
3phosphatidylinositol acyl-chain remodeling (GO:0036149)7.75242960
4benzene-containing compound metabolic process (GO:0042537)7.33160176
5phosphatidylserine acyl-chain remodeling (GO:0036150)7.17826909
6phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.88010150
7tonic smooth muscle contraction (GO:0014820)6.84229339
8extracellular matrix assembly (GO:0085029)5.91320320
9response to water (GO:0009415)5.73365993
10cellular response to osmotic stress (GO:0071470)5.70623586
11lipoxygenase pathway (GO:0019372)5.68946002
12cyclooxygenase pathway (GO:0019371)5.56091065
13negative regulation of cardiac muscle tissue growth (GO:0055022)5.51566372
14negative regulation of heart growth (GO:0061117)5.51566372
15thrombin receptor signaling pathway (GO:0070493)5.40876855
16phosphatidylserine metabolic process (GO:0006658)5.30114746
17negative regulation of cardiac muscle hypertrophy (GO:0010614)5.21161308
18phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.20595818
19lung vasculature development (GO:0060426)5.08969621
20parturition (GO:0007567)4.92676812
21spindle assembly involved in mitosis (GO:0090307)4.88633707
22establishment of apical/basal cell polarity (GO:0035089)4.87757471
23aggressive behavior (GO:0002118)4.84191093
24glutathione metabolic process (GO:0006749)4.82362838
25water transport (GO:0006833)4.74298054
26polarized epithelial cell differentiation (GO:0030859)4.71160379
27phosphatidylcholine acyl-chain remodeling (GO:0036151)4.69675383
28smooth muscle contraction (GO:0006939)4.64524777
29lung lobe morphogenesis (GO:0060463)4.61507763
30desmosome organization (GO:0002934)4.59891050
31alditol phosphate metabolic process (GO:0052646)4.59136758
32negative regulation of muscle hypertrophy (GO:0014741)4.58327174
33protein autoprocessing (GO:0016540)4.52546653
34platelet aggregation (GO:0070527)4.51223923
35respiratory tube development (GO:0030323)4.50704582
36positive regulation of Cdc42 GTPase activity (GO:0043089)4.48506428
37regulation of plasminogen activation (GO:0010755)4.36068038
38prostaglandin metabolic process (GO:0006693)4.35161865
39prostanoid metabolic process (GO:0006692)4.35161865
40response to phenylpropanoid (GO:0080184)4.35095481
41mRNA transcription from RNA polymerase II promoter (GO:0042789)4.32817366
42vascular smooth muscle contraction (GO:0014829)4.22214515
43establishment or maintenance of monopolar cell polarity (GO:0061339)4.21147486
44establishment of monopolar cell polarity (GO:0061162)4.21147486
45lung morphogenesis (GO:0060425)4.20908256
46planar cell polarity pathway involved in neural tube closure (GO:0090179)4.17383958
47relaxation of smooth muscle (GO:0044557)4.13190553
48fluid transport (GO:0042044)4.11078383
49galactose catabolic process (GO:0019388)4.10538229
50protein localization to cell surface (GO:0034394)4.09771346
51negative regulation of kidney development (GO:0090185)4.01663901
52regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.98148693
53primary alcohol catabolic process (GO:0034310)3.95778806
54cellular glucuronidation (GO:0052695)3.90710723
55mesonephros development (GO:0001823)3.85840730
56mRNA transcription (GO:0009299)3.79022632
57regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.77178058
58multicellular organismal water homeostasis (GO:0050891)3.72020958
59midgut development (GO:0007494)3.69314623
60phosphatidic acid metabolic process (GO:0046473)3.69051655
61phosphatidic acid biosynthetic process (GO:0006654)3.69051655
62uronic acid metabolic process (GO:0006063)3.66622667
63glucuronate metabolic process (GO:0019585)3.66622667
64microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.66545385
65regulation of ruffle assembly (GO:1900027)3.63512720
66negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.61444092
67regulation of cardiac muscle hypertrophy (GO:0010611)3.59695419
68cGMP-mediated signaling (GO:0019934)3.59241247
69regulation of cardiac muscle cell differentiation (GO:2000725)3.57777547
70regulation of water loss via skin (GO:0033561)3.55551698
71regulation of Cdc42 GTPase activity (GO:0043088)3.53650198
72endocardial cushion development (GO:0003197)3.51474513
73negative regulation of glycoprotein biosynthetic process (GO:0010561)3.49056519
74establishment of planar polarity (GO:0001736)3.47854417
75establishment of tissue polarity (GO:0007164)3.47854417
76endocardial cushion morphogenesis (GO:0003203)3.46238215
77regulation of clathrin-mediated endocytosis (GO:2000369)3.45085336
78ethanol metabolic process (GO:0006067)3.43665163
79negative regulation of cardiac muscle tissue development (GO:0055026)3.42991232
80vasoconstriction (GO:0042310)3.42810530
81regulation of muscle hypertrophy (GO:0014743)3.42403736
82phosphatidylglycerol metabolic process (GO:0046471)3.40921725
83establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.40221709
84cellular modified amino acid biosynthetic process (GO:0042398)3.38040925
85ovulation (GO:0030728)3.30156955
86intestinal epithelial cell development (GO:0060576)3.27880524
87regulation of protein glycosylation (GO:0060049)3.26478460
88regulation of skeletal muscle contraction (GO:0014819)3.25296760
89DNA integration (GO:0015074)3.24819679
90face development (GO:0060324)3.22825343
91glutathione biosynthetic process (GO:0006750)3.19397360
92positive regulation of cellular amine metabolic process (GO:0033240)3.18872204
93xenobiotic catabolic process (GO:0042178)3.18608549
94endothelial cell morphogenesis (GO:0001886)3.18090221
95homotypic cell-cell adhesion (GO:0034109)3.17129965
96branching involved in mammary gland duct morphogenesis (GO:0060444)3.13798360
97acrosome reaction (GO:0007340)3.13366277
98sphingosine metabolic process (GO:0006670)3.11633428
99water homeostasis (GO:0030104)3.10923634
100nonribosomal peptide biosynthetic process (GO:0019184)3.08350089
101regulation of interleukin-13 production (GO:0032656)3.07898958
102renal filtration (GO:0097205)3.06390613
103establishment of skin barrier (GO:0061436)3.04882178
104one-carbon compound transport (GO:0019755)20.0987349
105fibroblast migration (GO:0010761)2.99887799
106glutathione derivative metabolic process (GO:1901685)2.98877447
107glutathione derivative biosynthetic process (GO:1901687)2.98877447
108eyelid development in camera-type eye (GO:0061029)2.97700965
109mesenchyme morphogenesis (GO:0072132)2.96827614
110renal system development (GO:0072001)2.96764860
111regulation of keratinocyte differentiation (GO:0045616)2.96735253
112negative regulation of catenin import into nucleus (GO:0035414)2.96174168
113positive regulation of SMAD protein import into nucleus (GO:0060391)2.95719499
114diol metabolic process (GO:0034311)2.94120788
115negative regulation of glycoprotein metabolic process (GO:1903019)2.93820330
116viral transcription (GO:0019083)2.93233037
117epithelial cell-cell adhesion (GO:0090136)2.92086303
118outflow tract septum morphogenesis (GO:0003148)2.91127176
119regulation of muscle adaptation (GO:0043502)2.90243052
120muscle contraction (GO:0006936)2.89491219
121establishment of epithelial cell polarity (GO:0090162)2.88431826
122hepatocyte apoptotic process (GO:0097284)2.88087999
123glomerular filtration (GO:0003094)2.87676305
124protein heterotrimerization (GO:0070208)2.86390198
125carnitine shuttle (GO:0006853)2.84930442
126embryonic foregut morphogenesis (GO:0048617)2.84780514
127ectodermal placode formation (GO:0060788)2.84703258
128cardiac muscle cell development (GO:0055013)2.84328779
129purinergic nucleotide receptor signaling pathway (GO:0035590)2.84252192
130G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.81876935
131dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.80232240
132establishment or maintenance of apical/basal cell polarity (GO:0035088)2.79919202
133establishment or maintenance of bipolar cell polarity (GO:0061245)2.79919202
134translational termination (GO:0006415)2.78069750
135lung epithelium development (GO:0060428)2.76324203
136surfactant homeostasis (GO:0043129)2.75626169
137regulation of SMAD protein import into nucleus (GO:0060390)2.75520614
138cardiac cell development (GO:0055006)2.73825088
139relaxation of muscle (GO:0090075)2.73319410
140Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.71850584
141regulation of cardiac muscle tissue growth (GO:0055021)2.71166259
142mesodermal cell differentiation (GO:0048333)2.70000724
143ectoderm development (GO:0007398)2.69996856
144regulation of smooth muscle contraction (GO:0006940)2.69466729
145fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.68745315
146regulation of apoptotic process involved in morphogenesis (GO:1902337)2.66241847
147epithelial cell differentiation involved in prostate gland development (GO:0060742)2.63085864
148positive regulation of keratinocyte differentiation (GO:0045618)2.62873746
149norepinephrine metabolic process (GO:0042415)2.62787136
150early endosome to late endosome transport (GO:0045022)2.61454718
151regulation of smooth muscle cell differentiation (GO:0051150)2.60700666
152cell differentiation involved in metanephros development (GO:0072202)2.58592741
153sphingoid metabolic process (GO:0046519)2.57415539
154cell volume homeostasis (GO:0006884)2.56882554
155negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.55569446
156negative regulation of stress fiber assembly (GO:0051497)2.54445378
157muscle system process (GO:0003012)2.54343617
158negative regulation of embryonic development (GO:0045992)2.54298681
159ear development (GO:0043583)2.54127043
160SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.53386853
161positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.51721059
162protein localization to endoplasmic reticulum (GO:0070972)2.51150200
163protein targeting to ER (GO:0045047)2.50737633
164amyloid precursor protein metabolic process (GO:0042982)2.50206294
165regulation of interleukin-5 production (GO:0032674)2.49568103
166regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.48687937
167cotranslational protein targeting to membrane (GO:0006613)2.47849113
168cellular modified amino acid metabolic process (GO:0006575)2.45442986
169bundle of His cell to Purkinje myocyte communication (GO:0086069)2.43201506
170establishment of protein localization to endoplasmic reticulum (GO:0072599)2.42891409
171citrulline biosynthetic process (GO:0019240)16.4830892
172response to nitrosative stress (GO:0051409)16.2948993
173hypotonic response (GO:0006971)11.4108022
174citrulline metabolic process (GO:0000052)11.0757449
175potassium ion homeostasis (GO:0055075)10.8863555

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.05372196
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.80140966
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.17047152
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.01171501
5CLOCK_20551151_ChIP-Seq_293T_Human2.87944476
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.79599033
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.70019371
8ERG_21242973_ChIP-ChIP_JURKAT_Human2.60512957
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.56017434
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.41768283
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.32786686
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.25494221
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.24591342
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.22919101
15CDX2_20551321_ChIP-Seq_CACO-2_Human2.22403961
16RACK7_27058665_Chip-Seq_MCF-7_Human2.10118248
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.10080034
18* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.07280167
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.05525836
20ZFP281_18757296_ChIP-ChIP_E14_Mouse2.02014436
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.97228712
22GATA3_24758297_ChIP-Seq_MCF-7_Human1.93312642
23GATA6_25053715_ChIP-Seq_YYC3_Human1.91951076
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.91187150
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.91187150
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.91187150
27PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.89127287
28ZNF263_19887448_ChIP-Seq_K562_Human1.87936892
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.87702227
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85380174
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.75122662
32TCF3_18692474_ChIP-Seq_MEFs_Mouse1.69290591
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66582591
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65851734
35NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.65637077
36P63_26484246_Chip-Seq_KERATINOCYTES_Human1.59502782
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.57089973
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53546505
39EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.53030681
40LXR_22292898_ChIP-Seq_THP-1_Human1.50957612
41TCF3_18692474_ChIP-Seq_MESCs_Mouse1.50377951
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50283782
43SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.49605136
44UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.49323123
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48779613
46NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.48540957
47SOX2_20726797_ChIP-Seq_SW620_Human1.45891481
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44986902
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.44860829
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44676050
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44210893
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42889263
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42379277
54NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40948877
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40677077
56RXR_22158963_ChIP-Seq_LIVER_Mouse1.40600030
57* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.37915899
58GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.36679806
59AHR_22903824_ChIP-Seq_MCF-7_Human1.35783363
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.35159406
61CTCF_27219007_Chip-Seq_Bcells_Human1.34134195
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33707610
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33507679
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32477315
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32392855
66PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29671040
67* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29437096
68FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.29100099
69TP53_20018659_ChIP-ChIP_R1E_Mouse1.27197851
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26891520
71SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26891520
72BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.26658826
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26006942
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25824724
75SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24987764
76TP53_18474530_ChIP-ChIP_U2OS_Human1.23571697
77KLF5_25053715_ChIP-Seq_YYC3_Human1.23419707
78SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.23099148
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21708125
80* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.20707205
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20549245
82RUNX1_27514584_Chip-Seq_MCF-7_Human1.19429789
83ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19152485
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18849192
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16768714
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16768714
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16611925
88SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16574707
89TP63_22573176_ChIP-Seq_HFKS_Human1.16462051
90CJUN_26792858_Chip-Seq_BT549_Human1.16387486
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13643942
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10725113
93GATA4_25053715_ChIP-Seq_YYC3_Human1.10710714
94CSB_26484114_Chip-Seq_FIBROBLAST_Human1.10624734
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10493268
96* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10144005
97KDM2B_26808549_Chip-Seq_K562_Human1.09417650
98NANOG_18692474_ChIP-Seq_MEFs_Mouse1.09336257
99SA1_27219007_Chip-Seq_ERYTHROID_Human1.09173050
100EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07307213
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07231869
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06960762
103SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06793299
104TP53_16413492_ChIP-PET_HCT116_Human1.06431958
105ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05994223
106EP300_21415370_ChIP-Seq_HL-1_Mouse1.05087109
107CREB1_26743006_Chip-Seq_LNCaP_Human1.03725323
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02655429
109MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01541821
110NANOG_18692474_ChIP-Seq_MESCs_Mouse1.01234479
111TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01174669
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01073657
113SMC4_20622854_ChIP-Seq_HELA_Human1.01055827
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00974014
115SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00215340
116* TET1_21451524_ChIP-Seq_MESCs_Mouse0.99951157
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99780765
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99629333
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.99613029
120ATF3_27146783_Chip-Seq_COLON_Human0.99141311
121SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99121337
122HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99107777
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98243321
124ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98045924
125NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97298572
126CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97200749
127OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96857098
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.95889141
129BCL6_27268052_Chip-Seq_Bcells_Human0.95877409
130P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.95575625
131* SA1_27219007_Chip-Seq_Bcells_Human0.95180528
132CHD1_26751641_Chip-Seq_LNCaP_Human0.94755413
133AR_21909140_ChIP-Seq_LNCAP_Human0.93911011
134KAP1_27257070_Chip-Seq_ESCs_Mouse0.91182840
135HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89526700
136ELF5_23300383_ChIP-Seq_T47D_Human0.88053088
137GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87748918
138GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87378936
139CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86085456
140PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85997846
141BCOR_27268052_Chip-Seq_Bcells_Human0.83847855
142RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83089108
143LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81758907
144TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.81031374
145SOX11_22085726_ChIP-Seq_ESNs_Mouse0.80772750
146EOMES_21245162_ChIP-Seq_HESCs_Human0.80604801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005367_renal/urinary_system_phenotyp9.55110506
2* MP0000516_abnormal_urinary_system9.55110506
3MP0000566_synostosis4.90355105
4MP0010234_abnormal_vibrissa_follicle4.42308864
5* MP0000534_abnormal_ureter_morphology3.91250483
6* MP0010386_abnormal_urinary_bladder3.86586069
7MP0005377_hearing/vestibular/ear_phenot3.29237733
8MP0003878_abnormal_ear_physiology3.29237733
9* MP0001756_abnormal_urination3.27749257
10MP0001958_emphysema2.86920454
11MP0001905_abnormal_dopamine_level2.69085855
12MP0000013_abnormal_adipose_tissue2.54050599
13MP0000462_abnormal_digestive_system2.50876551
14MP0006054_spinal_hemorrhage2.42245447
15MP0001664_abnormal_digestion2.41617977
16MP0005501_abnormal_skin_physiology2.39145459
17MP0002837_dystrophic_cardiac_calcinosis2.36555124
18MP0008438_abnormal_cutaneous_collagen2.30194355
19MP0008872_abnormal_physiological_respon2.23575788
20MP0005275_abnormal_skin_tensile2.21290499
21MP0002098_abnormal_vibrissa_morphology2.07000401
22MP0010678_abnormal_skin_adnexa1.96486061
23MP0001765_abnormal_ion_homeostasis1.90907064
24MP0003566_abnormal_cell_adhesion1.90572157
25MP0004036_abnormal_muscle_relaxation1.87689022
26MP0003283_abnormal_digestive_organ1.86193834
27MP0000538_abnormal_urinary_bladder1.85539312
28MP0005330_cardiomyopathy1.77861225
29MP0009053_abnormal_anal_canal1.72475306
30MP0005620_abnormal_muscle_contractility1.71349418
31MP0000230_abnormal_systemic_arterial1.68127875
32MP0000383_abnormal_hair_follicle1.66708935
33MP0004185_abnormal_adipocyte_glucose1.66331511
34MP0001216_abnormal_epidermal_layer1.65655470
35MP0002254_reproductive_system_inflammat1.64835950
36MP0003705_abnormal_hypodermis_morpholog1.56859877
37MP0000537_abnormal_urethra_morphology1.55995017
38MP0004381_abnormal_hair_follicle1.47975780
39MP0008875_abnormal_xenobiotic_pharmacok1.46296189
40MP0005332_abnormal_amino_acid1.45626176
41MP0000751_myopathy1.41304729
42MP0004272_abnormal_basement_membrane1.39573061
43MP0000377_abnormal_hair_follicle1.37586096
44MP0005503_abnormal_tendon_morphology1.36276449
45MP0002796_impaired_skin_barrier1.36079918
46MP0005595_abnormal_vascular_smooth1.31082862
47MP0010771_integument_phenotype1.27895591
48MP0001270_distended_abdomen1.21387914
49MP0000627_abnormal_mammary_gland1.18085804
50MP0001849_ear_inflammation1.17202462
51MP0001873_stomach_inflammation1.16806721
52MP0005636_abnormal_mineral_homeostasis1.15298886
53MP0003385_abnormal_body_wall1.13823690
54MP0004084_abnormal_cardiac_muscle1.10919501
55MP0005075_abnormal_melanosome_morpholog1.07174655
56MP0002249_abnormal_larynx_morphology1.05986838
57MP0000465_gastrointestinal_hemorrhage0.99538500
58MP0000750_abnormal_muscle_regeneration0.96194472
59MP0003315_abnormal_perineum_morphology0.94059501
60MP0004858_abnormal_nervous_system0.93581842
61MP0003638_abnormal_response/metabolism_0.92047212
62MP0003191_abnormal_cellular_cholesterol0.89664050
63MP0000003_abnormal_adipose_tissue0.89110546
64MP0002089_abnormal_postnatal_growth/wei0.88515974
65MP0004782_abnormal_surfactant_physiolog0.88315693
66MP0005023_abnormal_wound_healing0.87840159
67MP0005394_taste/olfaction_phenotype0.86456150
68MP0005499_abnormal_olfactory_system0.86456150
69MP0003942_abnormal_urinary_system0.84000558
70* MP0009643_abnormal_urine_homeostasis0.83671842
71MP0004947_skin_inflammation0.83602325
72MP0003936_abnormal_reproductive_system0.83092077
73MP0005375_adipose_tissue_phenotype0.81806103
74MP0005058_abnormal_lysosome_morphology0.81467289
75MP0004019_abnormal_vitamin_homeostasis0.80885215
76MP0004130_abnormal_muscle_cell0.80063351
77MP0005381_digestive/alimentary_phenotyp0.78630390
78MP0005666_abnormal_adipose_tissue0.78264280
79MP0001340_abnormal_eyelid_morphology0.77934025
80MP0002282_abnormal_trachea_morphology0.76465881
81MP0000367_abnormal_coat/_hair0.76352360
82MP0005076_abnormal_cell_differentiation0.75943766
83MP0002909_abnormal_adrenal_gland0.75133433
84MP0005187_abnormal_penis_morphology0.74832889
85MP0002127_abnormal_cardiovascular_syste0.74721147
86MP0003115_abnormal_respiratory_system0.74624455
87MP0009379_abnormal_foot_pigmentation0.73493174
88MP0010352_gastrointestinal_tract_polyps0.73438348
89MP0003453_abnormal_keratinocyte_physiol0.72976670
90MP0000579_abnormal_nail_morphology0.72681858
91MP0000762_abnormal_tongue_morphology0.72496313
92MP0005319_abnormal_enzyme/_coenzyme0.70760586
93MP0005164_abnormal_response_to0.70531380
94MP0000767_abnormal_smooth_muscle0.69936182
95MP0010030_abnormal_orbit_morphology0.69837660
96MP0008789_abnormal_olfactory_epithelium0.69333349
97MP0003938_abnormal_ear_development0.69243451
98MP0001346_abnormal_lacrimal_gland0.68551111
99MP0000427_abnormal_hair_cycle0.67405760
100MP0002233_abnormal_nose_morphology0.66635736
101MP0003183_abnormal_peptide_metabolism0.66207809
102MP0005365_abnormal_bile_salt0.65456072
103MP0005670_abnormal_white_adipose0.64942546
104MP0005166_decreased_susceptibility_to0.64876956
105MP0000681_abnormal_thyroid_gland0.62226504
106MP0000249_abnormal_blood_vessel0.61585173
107MP0000678_abnormal_parathyroid_gland0.61192139
108MP0000613_abnormal_salivary_gland0.60902799
109MP0003941_abnormal_skin_development0.60564707
110MP0005388_respiratory_system_phenotype0.60106407
111MP0002133_abnormal_respiratory_system0.60106407
112MP0002060_abnormal_skin_morphology0.59912519
113MP0002822_catalepsy0.59264705
114MP0010630_abnormal_cardiac_muscle0.59126833
115MP0002108_abnormal_muscle_morphology0.58874576
116* MP0002135_abnormal_kidney_morphology0.58366188
117MP0001666_abnormal_nutrient_absorption0.58319442
118* MP0002136_abnormal_kidney_physiology0.57967511
119MP0004484_altered_response_of0.57837103
120MP0000647_abnormal_sebaceous_gland0.56779036
121MP0000163_abnormal_cartilage_morphology0.56426569
122MP0002092_abnormal_eye_morphology0.56046433
123MP0003252_abnormal_bile_duct0.55136538
124MP0009780_abnormal_chondrocyte_physiolo0.54165043
125MP0004087_abnormal_muscle_fiber0.53362473
126MP0003279_aneurysm0.53099466
127MP0005197_abnormal_uvea_morphology0.53073057
128MP0000467_abnormal_esophagus_morphology0.52378673
129MP0009931_abnormal_skin_appearance0.52104939
130MP0003935_abnormal_craniofacial_develop0.51927278
131MP0004264_abnormal_extraembryonic_tissu0.51830678
132MP0002128_abnormal_blood_circulation0.51800978
133MP0005623_abnormal_meninges_morphology0.50122960
134MP0003806_abnormal_nucleotide_metabolis0.49616343
135MP0003866_abnormal_defecation0.48141732
136MP0001614_abnormal_blood_vessel0.47724034
137MP0006138_congestive_heart_failure0.46496798
138MP0005083_abnormal_biliary_tract0.46204152
139MP0008004_abnormal_stomach_pH0.45733334
140MP0005408_hypopigmentation0.45648622
141MP0004215_abnormal_myocardial_fiber0.45351705
142MP0002234_abnormal_pharynx_morphology0.45099981
143MP0005248_abnormal_Harderian_gland0.45000485
144MP0000470_abnormal_stomach_morphology0.44747820
145MP0003011_delayed_dark_adaptation0.43267267
146MP0002925_abnormal_cardiovascular_devel0.42799461
147MP0004134_abnormal_chest_morphology0.42591982
148MP0004043_abnormal_pH_regulation0.42388811
149MP0002972_abnormal_cardiac_muscle0.42354809
150MP0001485_abnormal_pinna_reflex0.41820094
151MP0005165_increased_susceptibility_to0.39862094
152MP0003879_abnormal_hair_cell0.39313047
153MP0000477_abnormal_intestine_morphology0.38471875
154MP0001243_abnormal_dermal_layer0.38434529
155MP0003186_abnormal_redox_activity0.37699220
156MP0009672_abnormal_birth_weight0.36767509
157MP0001881_abnormal_mammary_gland0.35195123
158MP0003953_abnormal_hormone_level0.34262136
159MP0002111_abnormal_tail_morphology0.34200371
160MP0009333_abnormal_splenocyte_physiolog0.33844865

Predicted human phenotypes

RankGene SetZ-score
1Aortic dissection (HP:0002647)8.01413573
2Eczematoid dermatitis (HP:0000976)7.63583356
3Neoplasm of the heart (HP:0100544)6.90341188
4Gastrointestinal dysmotility (HP:0002579)6.78665686
5Long clavicles (HP:0000890)6.76981847
6Lip pit (HP:0100267)6.53654461
7Seborrheic dermatitis (HP:0001051)6.37807954
8Malnutrition (HP:0004395)6.29982068
9Cerebral palsy (HP:0100021)6.17778952
10Growth hormone excess (HP:0000845)5.83226519
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.58031891
12Ankle contracture (HP:0006466)5.43268934
13Cerebral aneurysm (HP:0004944)5.24748358
14Abnormality of abdominal situs (HP:0011620)5.16821820
15Abdominal situs inversus (HP:0003363)5.16821820
16Parakeratosis (HP:0001036)4.86160934
17Abnormality of the salivary glands (HP:0010286)4.85689305
18Ulnar bowing (HP:0003031)4.72661906
19Hydroureter (HP:0000072)4.68703451
20Congenital ichthyosiform erythroderma (HP:0007431)4.36690363
21Stridor (HP:0010307)4.33988139
22Hyperactive renin-angiotensin system (HP:0000841)4.28710252
23Redundant skin (HP:0001582)4.23478151
24Increased density of long bones (HP:0006392)4.15265667
25Wrist flexion contracture (HP:0001239)4.03682789
26Absent frontal sinuses (HP:0002688)4.02374889
27Aortic regurgitation (HP:0001659)4.02152772
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.94207820
29Short 4th metacarpal (HP:0010044)3.94207820
30Palmoplantar hyperkeratosis (HP:0000972)3.90275289
31Broad distal phalanx of finger (HP:0009836)3.89909769
32Mesomelia (HP:0003027)3.87785138
33Abnormal pupillary function (HP:0007686)3.76614701
34Septate vagina (HP:0001153)3.66654535
35Palmar hyperkeratosis (HP:0010765)3.66111069
36Plantar hyperkeratosis (HP:0007556)3.61482109
37Long toe (HP:0010511)3.59994494
38Selective tooth agenesis (HP:0001592)3.56429324
39Scapular winging (HP:0003691)3.55995196
40Abnormal foot bone ossification (HP:0010675)3.53502003
41Thickened calvaria (HP:0002684)3.51952418
42Broad face (HP:0000283)3.46602901
43Short hallux (HP:0010109)3.41469380
44Acanthocytosis (HP:0001927)3.35452361
45Aneurysm (HP:0002617)3.33774258
46Bicuspid aortic valve (HP:0001647)3.33539570
47Long foot (HP:0001833)3.28403907
48Dilatation of the ascending aorta (HP:0005111)3.26681376
49Abnormality of the 2nd finger (HP:0004100)3.24810382
50Spastic diplegia (HP:0001264)3.23568426
51Radial bowing (HP:0002986)3.21837715
52Facial diplegia (HP:0001349)3.19674667
53Aplasia/Hypoplasia of the hallux (HP:0008362)3.15619744
54Persistence of primary teeth (HP:0006335)3.13984175
55Abnormality of the calcaneus (HP:0008364)3.03303575
56Polygenic inheritance (HP:0010982)2.99963669
57Abnormality of the 4th metacarpal (HP:0010012)2.97066240
58Tarsal synostosis (HP:0008368)2.94118010
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.93008976
60Osteolytic defects of the hand bones (HP:0009699)2.93008976
61Abnormality of the right ventricle (HP:0001707)2.91550603
62Hyperparathyroidism (HP:0000843)2.87478417
63Bowing of the arm (HP:0006488)2.84261027
64Bowed forearm bones (HP:0003956)2.84261027
65Type 1 muscle fiber predominance (HP:0003803)2.84025670
66Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.83546193
67Focal segmental glomerulosclerosis (HP:0000097)2.82069826
68Ureteral stenosis (HP:0000071)2.81644840
69Abnormal ossification of hand bones (HP:0005921)2.79015671
70Fused cervical vertebrae (HP:0002949)2.77730168
71Abnormality of the dental root (HP:0006486)2.75111021
72Taurodontia (HP:0000679)2.75111021
73Abnormality of permanent molar morphology (HP:0011071)2.75111021
74Increased mean platelet volume (HP:0011877)2.74880701
75Abnormality of the gastric mucosa (HP:0004295)2.74446047
76Abnormality of the axillary hair (HP:0100134)2.71297326
77Abnormality of secondary sexual hair (HP:0009888)2.71297326
78Camptodactyly of toe (HP:0001836)2.65741205
79Synostosis involving bones of the feet (HP:0009140)2.65491240
80Synostosis involving bones of the lower limbs (HP:0009138)2.65491240
81Abnormality of oral frenula (HP:0000190)2.64144782
82Onycholysis (HP:0001806)2.62202253
83Elbow flexion contracture (HP:0002987)2.61854918
84Erythroderma (HP:0001019)2.61379950
85Disproportionate tall stature (HP:0001519)2.57340013
86Partial duplication of thumb phalanx (HP:0009944)2.54947920
87Ureteral obstruction (HP:0006000)2.54888989
88Acanthosis nigricans (HP:0000956)2.54286619
89Renal salt wasting (HP:0000127)2.49289717
90Blepharitis (HP:0000498)2.48411046
91Abnormality of molar (HP:0011077)2.47025232
92Abnormality of molar morphology (HP:0011070)2.47025232
93Hyperpituitarism (HP:0010514)2.44656551
94Genu varum (HP:0002970)2.42781775
95Chronic bronchitis (HP:0004469)2.42582404
96Knee flexion contracture (HP:0006380)2.42343283
97Muscle fiber splitting (HP:0003555)2.41915558
98Intestinal malrotation (HP:0002566)2.41162464
99Distal lower limb muscle weakness (HP:0009053)2.40884195
100Abnormal platelet volume (HP:0011876)2.40864914
101Glomerulosclerosis (HP:0000096)2.35976963
102Short humerus (HP:0005792)2.33884269
103Pili torti (HP:0003777)2.33853321
104Hemorrhage of the eye (HP:0011885)2.33399579
105Aplasia involving bones of the extremities (HP:0009825)2.33312937
106Aplasia involving bones of the upper limbs (HP:0009823)2.33312937
107Aplasia of the phalanges of the hand (HP:0009802)2.33312937
108Abnormality of the dental pulp (HP:0006479)2.33137904
109Clubbing of toes (HP:0100760)2.31813020
110Testicular atrophy (HP:0000029)2.31473909
111Hyperkalemia (HP:0002153)2.31028704
112Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.25907819
113Carpal synostosis (HP:0009702)2.25551516
114Aplasia of the musculature (HP:0100854)2.24849299
115Amelogenesis imperfecta (HP:0000705)2.24058614
116Abnormal hair laboratory examination (HP:0003328)2.23370236
117Breast hypoplasia (HP:0003187)2.23335847
118Micronodular cirrhosis (HP:0001413)2.22027515
119Conjugated hyperbilirubinemia (HP:0002908)2.20889097
120Joint swelling (HP:0001386)2.20423324
121Abnormality of the frontal sinuses (HP:0002687)2.18593912
122Synostosis of carpal bones (HP:0005048)2.18545296
123Aplasia/hypoplasia of the humerus (HP:0006507)2.18101725
124Stroke (HP:0001297)2.14516277
125Abnormality of the shoulder girdle musculature (HP:0001435)2.14344827
126Conical tooth (HP:0000698)2.12590783
127Tachypnea (HP:0002789)2.11440481
128Right ventricular cardiomyopathy (HP:0011663)2.10791331
129Abnormality of the distal phalanges of the toes (HP:0010182)2.10724939
130Nasolacrimal duct obstruction (HP:0000579)2.06926577
131Woolly hair (HP:0002224)2.06769586
132Concave nail (HP:0001598)2.06499594
133Partial duplication of the phalanx of hand (HP:0009999)2.06187784
134Short chin (HP:0000331)2.05384362
135Tongue fasciculations (HP:0001308)2.04460008
136Aplasia/Hypoplasia of the scapulae (HP:0006713)2.03306883
137Hypoplastic scapulae (HP:0000882)2.03306883
138Delayed closure of the anterior fontanelle (HP:0001476)2.01787243
139Absent toe (HP:0010760)2.00321958
140Aortic aneurysm (HP:0004942)10.6375238
141Popliteal pterygium (HP:0009756)1.99193381
142Aplasia/Hypoplasia of the clavicles (HP:0006710)1.98880668
143Hyperaldosteronism (HP:0000859)1.98009483
144Acne (HP:0001061)1.97206232
145Hypoplastic labia majora (HP:0000059)1.97148143
146Fibular hypoplasia (HP:0003038)1.97030230
147Hyperthyroidism (HP:0000836)1.96864011
148Hyporeflexia of lower limbs (HP:0002600)1.96556883
149Glossoptosis (HP:0000162)1.94657603
150Bone pain (HP:0002653)1.94363050
151Mitral valve prolapse (HP:0001634)1.94136553
152Arachnodactyly (HP:0001166)1.93757173
153Hydronephrosis (HP:0000126)1.93003118
154Short clavicles (HP:0000894)1.92951049
155Myelomeningocele (HP:0002475)1.92702575
156Abnormality of the distal phalanx of the thumb (HP:0009617)1.91191150
157Intrahepatic cholestasis (HP:0001406)1.90447823
158Abnormality of nail color (HP:0100643)1.90166311
159Increased variability in muscle fiber diameter (HP:0003557)1.90128134
160Dehydration (HP:0001944)1.89061019
161Sparse lateral eyebrow (HP:0005338)1.87940338
162Multifactorial inheritance (HP:0001426)1.87501887
163Complete atrioventricular canal defect (HP:0001674)1.86737726
164Osteoarthritis (HP:0002758)1.86343373
165Limb-girdle muscle atrophy (HP:0003797)1.86337674
166Wormian bones (HP:0002645)1.85759459
167Increased connective tissue (HP:0009025)1.85260671
168Vacuolated lymphocytes (HP:0001922)1.84787294
169Shawl scrotum (HP:0000049)1.84441744
170Trismus (HP:0000211)1.83074734
171Joint contractures involving the joints of the feet (HP:0100492)1.82772402
172Flexion contracture of toe (HP:0005830)1.82772402
173Abnormality of the lacrimal duct (HP:0011481)1.82501934
174Asymmetry of the thorax (HP:0001555)1.81791732
175Omphalocele (HP:0001539)1.81572846
176Hypoparathyroidism (HP:0000829)1.80995745
177Hyponatremia (HP:0002902)1.80261398
178Abnormality of the odontoid process (HP:0003310)1.79892824
179Congenital hip dislocation (HP:0001374)1.79344029
180Synostosis involving bones of the hand (HP:0004278)1.79233021
181Absent hand (HP:0004050)1.79173450
182Subcapsular cataract (HP:0000523)1.78979527
183Abnormal cortical bone morphology (HP:0003103)1.78319867
184Urinary glycosaminoglycan excretion (HP:0003541)1.77012616
185Mucopolysacchariduria (HP:0008155)1.77012616
186Aplasia cutis congenita (HP:0001057)1.74971393
187Abnormality of monocarboxylic acid metabolism (HP:0010996)1.73929074
188Abnormality of the labia majora (HP:0012881)1.73751520
189Spinal rigidity (HP:0003306)1.73088660
190Muscle fibrillation (HP:0010546)1.71872077
191Germ cell neoplasia (HP:0100728)1.71867366
192Broad metatarsal (HP:0001783)1.68361781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK8.91008743
2MAP3K123.99282900
3NME23.87248484
4DMPK3.64514654
5GRK53.61446872
6PAK22.66640682
7PIK3CG2.44430585
8MST1R2.20442062
9NME12.15228013
10EPHA22.08150291
11TTN10.2500634
12LMTK21.98470166
13DDR21.87245591
14SMG11.80881547
15IRAK31.78725910
16MINK11.70931708
17MAPKAPK31.60397317
18ILK1.46291283
19EPHB21.44512539
20CAMK2G1.43322546
21NUAK11.40288359
22CDK91.39238056
23CDK81.38386291
24RPS6KB21.32069059
25DAPK31.29315642
26CDC42BPA1.28179085
27PAK11.27423106
28RPS6KA21.16155918
29STK241.15900729
30MET1.15027644
31RIPK11.14804462
32MUSK1.10696881
33DAPK11.05768981
34MAP3K21.00916056
35PIK3CA0.94950557
36RAF10.92728267
37EEF2K0.92267623
38SIK30.89035046
39AKT30.88923182
40TESK20.88461026
41TRIB30.84422339
42CAMK2B0.82734563
43RPS6KL10.81913047
44RPS6KC10.81913047
45ROCK20.80538311
46FGFR30.78197306
47PAK30.78036367
48PTK20.77544765
49ROCK10.73339198
50VRK20.72956453
51PKN20.71724563
52FER0.71404018
53TESK10.70049838
54CAMK2D0.68605997
55RPS6KA60.66937094
56PHKG20.65858250
57PHKG10.65858250
58GSK3A0.65533600
59EIF2AK10.63995032
60AURKB0.63697416
61MELK0.62100026
62MAP2K20.61372764
63MAP4K10.60441077
64ERN10.57404810
65BRD40.56714525
66PDGFRA0.53319275
67TGFBR10.52816304
68JAK10.51831267
69MAPKAPK20.51789167
70WNK10.50017574
71LRRK20.49881183
72MAP2K60.49488215
73KSR20.49385661
74BMPR20.47314905
75MAPK40.46448885
76CAMK10.46397653
77EPHB10.46254110
78PRKACB0.46182712
79MAP3K30.44186548
80TGFBR20.43898956
81BCKDK0.41637659
82LIMK10.40993574
83STK160.40949798
84SIK10.39913375
85TAOK10.39538830
86FYN0.39401831
87CSF1R0.38901475
88MAP2K10.37934076
89NEK10.36903288
90TYRO30.36234142
91CHUK0.35850071
92NEK60.35257193
93STK38L0.34823320
94STK380.31016240
95FGFR10.30493689
96YES10.30278968
97PTK60.28927340
98PTK2B0.28923932
99MAP3K90.28861852
100CDK70.28433354
101ERBB20.28222152
102ABL20.25946740
103MTOR0.25226337
104BMX0.25207827
105MATK0.24662609
106KDR0.23039549
107IKBKB0.23023685
108CDK120.22889239
109TTK0.22390228
110TRPM70.21785760
111FGR0.21724092
112ICK0.21447136
113LATS10.21438659
114SCYL20.20616179
115PAK40.20578700
116RPS6KA40.20491922
117MAP3K70.20374573
118LATS20.19835560
119SRC0.18044142
120TBK10.17457598
121CSNK1G30.16735971
122PIM20.16468485
123ERBB30.16261755
124MAP2K40.16112793
125PBK0.15700236
126PRKD10.15507960
127STK390.14546875
128NTRK10.13803629
129RPS6KA10.13660376
130PRKCI0.13530750
131ARAF0.13203630
132CSK0.12771665
133INSR0.12753826
134PRKG10.12489216
135ALK0.11669840
136PDK30.10972954
137PDK40.10972954
138ABL10.10848035
139MAP3K60.10244581
140PRKCD0.09072605
141CSNK1A1L0.07689092
142MAP2K30.06258646
143MST40.06181033
144MAPKAPK50.04222662
145PRKD20.04015489
146TIE10.03657626
147CAMK2A0.02661036
148RET0.02153609

Predicted pathways (KEGG)

RankGene SetZ-score
1Bladder cancer_Homo sapiens_hsa052195.47067872
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.52330367
3Vascular smooth muscle contraction_Homo sapiens_hsa042704.49944007
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.13867367
5Linoleic acid metabolism_Homo sapiens_hsa005913.58626655
6Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.05603178
7Chemical carcinogenesis_Homo sapiens_hsa052042.71883475
8Arachidonic acid metabolism_Homo sapiens_hsa005902.53292727
9Phenylalanine metabolism_Homo sapiens_hsa003602.42786720
10Fat digestion and absorption_Homo sapiens_hsa049752.32771781
11Ether lipid metabolism_Homo sapiens_hsa005652.25487686
12Focal adhesion_Homo sapiens_hsa045102.22657510
13Histidine metabolism_Homo sapiens_hsa003402.12526509
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93699110
15beta-Alanine metabolism_Homo sapiens_hsa004101.92740012
16Other glycan degradation_Homo sapiens_hsa005111.91593467
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81985923
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.78301585
19Proteasome_Homo sapiens_hsa030501.75670057
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.74662231
21Tight junction_Homo sapiens_hsa045301.74591032
22ECM-receptor interaction_Homo sapiens_hsa045121.73558115
23Nitrogen metabolism_Homo sapiens_hsa009101.73415115
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72546379
25Glutathione metabolism_Homo sapiens_hsa004801.69028133
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.68561045
27Platelet activation_Homo sapiens_hsa046111.67578365
28Proteoglycans in cancer_Homo sapiens_hsa052051.66775187
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.55527101
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49088699
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47720385
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.45513161
33Gastric acid secretion_Homo sapiens_hsa049711.41816539
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.33921074
35Oxytocin signaling pathway_Homo sapiens_hsa049211.33136048
36Galactose metabolism_Homo sapiens_hsa000521.30074997
37Dilated cardiomyopathy_Homo sapiens_hsa054141.26844330
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.20813417
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19694567
40Fatty acid degradation_Homo sapiens_hsa000711.17106179
41Basal cell carcinoma_Homo sapiens_hsa052171.16493316
42Tyrosine metabolism_Homo sapiens_hsa003501.15116522
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13710370
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13356731
45Hippo signaling pathway_Homo sapiens_hsa043901.13353037
46Adherens junction_Homo sapiens_hsa045201.12690795
47PPAR signaling pathway_Homo sapiens_hsa033201.09576188
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08864703
49Fatty acid metabolism_Homo sapiens_hsa012121.08139781
50Hedgehog signaling pathway_Homo sapiens_hsa043401.03798878
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02975387
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.98054350
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97669701
54Amoebiasis_Homo sapiens_hsa051460.96550847
55Butanoate metabolism_Homo sapiens_hsa006500.95156602
56Pentose phosphate pathway_Homo sapiens_hsa000300.94384559
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93520986
58Arginine biosynthesis_Homo sapiens_hsa002200.91891747
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90332965
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89009301
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.88586101
62Fatty acid elongation_Homo sapiens_hsa000620.87562429
63Sulfur metabolism_Homo sapiens_hsa009200.84393889
64Oxidative phosphorylation_Homo sapiens_hsa001900.81097512
65TGF-beta signaling pathway_Homo sapiens_hsa043500.80673975
66Vibrio cholerae infection_Homo sapiens_hsa051100.79740284
67Sulfur relay system_Homo sapiens_hsa041220.79511010
68Fructose and mannose metabolism_Homo sapiens_hsa000510.78538342
69Bile secretion_Homo sapiens_hsa049760.76899789
70Tryptophan metabolism_Homo sapiens_hsa003800.75799419
71Cardiac muscle contraction_Homo sapiens_hsa042600.75100559
72Folate biosynthesis_Homo sapiens_hsa007900.73131179
73Ribosome_Homo sapiens_hsa030100.72887163
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72165182
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71733099
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.69906878
77Propanoate metabolism_Homo sapiens_hsa006400.69533683
78Arginine and proline metabolism_Homo sapiens_hsa003300.69206867
79Sphingolipid metabolism_Homo sapiens_hsa006000.69199499
80Protein digestion and absorption_Homo sapiens_hsa049740.64501641
81Starch and sucrose metabolism_Homo sapiens_hsa005000.63792610
82Melanogenesis_Homo sapiens_hsa049160.63042479
83Lysosome_Homo sapiens_hsa041420.62298785
84Pancreatic secretion_Homo sapiens_hsa049720.62287859
85Pyruvate metabolism_Homo sapiens_hsa006200.58879798
86Retinol metabolism_Homo sapiens_hsa008300.57699732
87Insulin resistance_Homo sapiens_hsa049310.57501912
88Calcium signaling pathway_Homo sapiens_hsa040200.56461901
89Insulin signaling pathway_Homo sapiens_hsa049100.56402743
90Carbon metabolism_Homo sapiens_hsa012000.56385263
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54823333
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54623205
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54461095
94Shigellosis_Homo sapiens_hsa051310.54313284
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53723383
96N-Glycan biosynthesis_Homo sapiens_hsa005100.53384075
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52856888
98Salmonella infection_Homo sapiens_hsa051320.52315605
99Ovarian steroidogenesis_Homo sapiens_hsa049130.51897719
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.51103625
101Circadian rhythm_Homo sapiens_hsa047100.50582246
102Endocytosis_Homo sapiens_hsa041440.49472969
103Biosynthesis of amino acids_Homo sapiens_hsa012300.48779857
104Parkinsons disease_Homo sapiens_hsa050120.48701955
105VEGF signaling pathway_Homo sapiens_hsa043700.47610342
106Inositol phosphate metabolism_Homo sapiens_hsa005620.47489643
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47355673
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47062803
109AMPK signaling pathway_Homo sapiens_hsa041520.46102391
110Base excision repair_Homo sapiens_hsa034100.42428806
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42228993
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.42226313
113Caffeine metabolism_Homo sapiens_hsa002320.42018074
114GnRH signaling pathway_Homo sapiens_hsa049120.41103122
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40679613
116Glucagon signaling pathway_Homo sapiens_hsa049220.40502341
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39279575
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38642127
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.37605365
120Alzheimers disease_Homo sapiens_hsa050100.36958084
121Notch signaling pathway_Homo sapiens_hsa043300.36157822
122Metabolic pathways_Homo sapiens_hsa011000.36097052
123Thyroid cancer_Homo sapiens_hsa052160.34573986
124Huntingtons disease_Homo sapiens_hsa050160.34065742
125Peroxisome_Homo sapiens_hsa041460.33522615
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33318626
127Prion diseases_Homo sapiens_hsa050200.33230875
128Rap1 signaling pathway_Homo sapiens_hsa040150.33107748
129ABC transporters_Homo sapiens_hsa020100.31886666
130Fatty acid biosynthesis_Homo sapiens_hsa000610.31072032
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30552555
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.30101072
133Hepatitis C_Homo sapiens_hsa051600.29901396
134Small cell lung cancer_Homo sapiens_hsa052220.28156203
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26424973
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25247005
137Pancreatic cancer_Homo sapiens_hsa052120.24617169
138Complement and coagulation cascades_Homo sapiens_hsa046100.24612283
139Gap junction_Homo sapiens_hsa045400.24344759
140Wnt signaling pathway_Homo sapiens_hsa043100.24223005
141Axon guidance_Homo sapiens_hsa043600.23792143
142Cysteine and methionine metabolism_Homo sapiens_hsa002700.21407176
143Endometrial cancer_Homo sapiens_hsa052130.19794128
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19442034
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18321224
146Chronic myeloid leukemia_Homo sapiens_hsa052200.16600106
147Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13968455
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09883115
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09642600
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.09496228

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