UPK3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral membrane proteins of urothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A (MIM 611559) (Deng et al., 2002 [PubMed 12446744]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mesonephros development (GO:0001823)8.19024976
2diterpenoid biosynthetic process (GO:0016102)7.42285757
3mesenchymal cell differentiation involved in kidney development (GO:0072161)6.49613920
4mesenchymal cell differentiation involved in renal system development (GO:2001012)6.49613920
5metanephric mesenchyme development (GO:0072075)6.35867953
6diaphragm development (GO:0060539)6.35756423
7terpenoid biosynthetic process (GO:0016114)5.88624617
8desmosome organization (GO:0002934)5.72820927
9low-density lipoprotein particle clearance (GO:0034383)5.63978772
10negative regulation of kidney development (GO:0090185)5.63021736
11kidney mesenchyme development (GO:0072074)5.45815564
12skeletal muscle organ development (GO:0060538)5.35045095
13regulation of cell proliferation involved in kidney development (GO:1901722)5.12778208
14face development (GO:0060324)5.04239806
15regulation of phospholipase A2 activity (GO:0032429)4.99759329
16metanephric epithelium development (GO:0072207)4.80556719
17protein heterotrimerization (GO:0070208)4.69672501
18cell differentiation involved in metanephros development (GO:0072202)4.65395022
19endocardial cushion development (GO:0003197)4.49117652
20regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.43797302
21regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.37608882
22basement membrane organization (GO:0071711)4.37361444
23prostanoid biosynthetic process (GO:0046457)4.35864061
24prostaglandin biosynthetic process (GO:0001516)4.35864061
25regulation of cardioblast differentiation (GO:0051890)4.33977546
26positive regulation of Cdc42 GTPase activity (GO:0043089)4.30500878
27negative regulation of metanephros development (GO:0072217)4.25136666
28hepatocyte apoptotic process (GO:0097284)4.08441505
29regulation of water loss via skin (GO:0033561)4.06735961
30regulation of cholesterol biosynthetic process (GO:0045540)4.04097433
31amyloid precursor protein metabolic process (GO:0042982)4.02465855
32response to water (GO:0009415)3.99105336
33activation of Rac GTPase activity (GO:0032863)3.98610972
34apoptotic cell clearance (GO:0043277)3.94901081
35renal filtration (GO:0097205)3.90241289
36branching involved in salivary gland morphogenesis (GO:0060445)3.84278087
37protein retention in ER lumen (GO:0006621)3.83128408
38atrioventricular valve morphogenesis (GO:0003181)3.82880374
39triglyceride catabolic process (GO:0019433)3.80768746
40embryonic camera-type eye development (GO:0031076)3.80107298
41norepinephrine metabolic process (GO:0042415)3.79980629
42cell proliferation involved in metanephros development (GO:0072203)3.78512101
43detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.77083442
44detection of temperature stimulus involved in sensory perception (GO:0050961)3.77083442
45regulation of clathrin-mediated endocytosis (GO:2000369)3.76959759
46proteasome assembly (GO:0043248)3.75854796
47regulation of sequestering of triglyceride (GO:0010889)3.75132950
48glomerular filtration (GO:0003094)3.74913975
49regulation of hippo signaling (GO:0035330)3.72060368
50cyclooxygenase pathway (GO:0019371)3.71226173
51white fat cell differentiation (GO:0050872)3.67819694
52fatty acid transmembrane transport (GO:1902001)3.66090781
53response to vitamin A (GO:0033189)3.65423933
54pattern specification involved in kidney development (GO:0061004)3.65308809
55maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.65002277
56positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.63678190
57citrulline biosynthetic process (GO:0019240)3.61683463
58pericardium development (GO:0060039)3.59633992
59regulation of glomerulus development (GO:0090192)3.59616472
60axon extension involved in axon guidance (GO:0048846)3.58840012
61neuron projection extension involved in neuron projection guidance (GO:1902284)3.58840012
62positive regulation of fatty acid beta-oxidation (GO:0032000)3.53717774
63retina vasculature morphogenesis in camera-type eye (GO:0061299)3.51539544
64membrane budding (GO:0006900)3.49205934
65embryonic skeletal joint morphogenesis (GO:0060272)3.48367709
66vascular endothelial growth factor signaling pathway (GO:0038084)3.48162398
67neutral lipid catabolic process (GO:0046461)3.45239070
68acylglycerol catabolic process (GO:0046464)3.45239070
69positive regulation of fatty acid oxidation (GO:0046321)3.44314013
70brown fat cell differentiation (GO:0050873)3.42438144
71cell proliferation involved in kidney development (GO:0072111)3.42406076
72prostanoid metabolic process (GO:0006692)3.40939857
73prostaglandin metabolic process (GO:0006693)3.40939857
74pinocytosis (GO:0006907)3.37316521
75lipid particle organization (GO:0034389)3.37078047
76negative regulation of cardiac muscle tissue growth (GO:0055022)3.36576744
77negative regulation of heart growth (GO:0061117)3.36576744
78carnitine shuttle (GO:0006853)3.35951871
79multicellular organismal water homeostasis (GO:0050891)3.33093984
80regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.30250471
81glomerular visceral epithelial cell development (GO:0072015)3.25910458
82cellular response to interferon-alpha (GO:0035457)3.23529368
83complement activation, alternative pathway (GO:0006957)3.22969103
84surfactant homeostasis (GO:0043129)3.21282328
85valine metabolic process (GO:0006573)3.20739285
86regulation of cholesterol storage (GO:0010885)3.19657979
87myelin maintenance (GO:0043217)3.17601907
88aggressive behavior (GO:0002118)3.16715283
89collagen fibril organization (GO:0030199)3.16415276
90blood vessel maturation (GO:0001955)3.15471924
91regulation of transforming growth factor beta2 production (GO:0032909)3.15198449
92Golgi transport vesicle coating (GO:0048200)3.14852028
93COPI coating of Golgi vesicle (GO:0048205)3.14852028
94cardiac myofibril assembly (GO:0055003)3.13630192
95glomerular basement membrane development (GO:0032836)3.11788919
96establishment of skin barrier (GO:0061436)3.10813834
97regulation of fatty acid beta-oxidation (GO:0031998)3.10182758
98regulation of tight junction assembly (GO:2000810)3.09659354
99biotin metabolic process (GO:0006768)3.09044371
100fibroblast migration (GO:0010761)3.07981876
101stress fiber assembly (GO:0043149)3.01131370
102xenobiotic catabolic process (GO:0042178)3.00912810
103regulation of fatty acid oxidation (GO:0046320)2.98499174
104epithelial cell-cell adhesion (GO:0090136)2.98090755
105cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.95701919
106protein autoprocessing (GO:0016540)2.92815727
107endothelial cell morphogenesis (GO:0001886)2.90217877
108negative regulation of viral release from host cell (GO:1902187)2.90204929
109glomerular epithelial cell development (GO:0072310)2.89657974
110endosome organization (GO:0007032)2.88573977
111regulation of integrin-mediated signaling pathway (GO:2001044)2.87990210
112atrial septum morphogenesis (GO:0060413)2.86799606
113lymph vessel development (GO:0001945)2.85811071
114fatty acid beta-oxidation (GO:0006635)2.85614824
115deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.85374869
116negative regulation of fatty acid transport (GO:2000192)2.84668297
117retinal metabolic process (GO:0042574)2.84427083
118morphogenesis of embryonic epithelium (GO:0016331)2.84078020
119cell-substrate junction assembly (GO:0007044)2.83894580
120ovulation from ovarian follicle (GO:0001542)2.83870157
121negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.82449040
122growth hormone receptor signaling pathway (GO:0060396)2.81213692
123citrulline metabolic process (GO:0000052)2.80666606
124glucose catabolic process (GO:0006007)2.80200328
125diol metabolic process (GO:0034311)2.79431771
126negative regulation of lipase activity (GO:0060192)2.78645701
127sphingosine metabolic process (GO:0006670)2.78105265
128focal adhesion assembly (GO:0048041)2.78052776
129cell-substrate adherens junction assembly (GO:0007045)2.78052776
130water homeostasis (GO:0030104)2.77224198
131peptidyl-arginine modification (GO:0018195)2.76672903
132regulation of endothelial cell differentiation (GO:0045601)2.76178996
133respiratory tube development (GO:0030323)2.76104935
134embryonic foregut morphogenesis (GO:0048617)2.76080665
135sarcomere organization (GO:0045214)2.75912600
136venous blood vessel morphogenesis (GO:0048845)2.75602959
137regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.75135733
138plasma lipoprotein particle clearance (GO:0034381)2.75064417
139plasma membrane repair (GO:0001778)2.72129185
140mesenchymal cell proliferation (GO:0010463)2.70896653
141metanephric nephron epithelium development (GO:0072243)2.69882759
142cell migration involved in heart development (GO:0060973)2.68737547
143endodermal cell differentiation (GO:0035987)2.68168657
144regulation of cellular amino acid metabolic process (GO:0006521)2.67008995
145negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.66504586
146heart trabecula formation (GO:0060347)2.65952486
147vitamin A metabolic process (GO:0006776)2.65360806
148positive regulation of fatty acid metabolic process (GO:0045923)2.64387768
149cell differentiation involved in embryonic placenta development (GO:0060706)2.63836611
150positive regulation of endothelial cell apoptotic process (GO:2000353)2.62446332
151glomerulus development (GO:0032835)2.61653618
152amyloid precursor protein catabolic process (GO:0042987)2.61629037
153polarized epithelial cell differentiation (GO:0030859)2.61171600
154hippo signaling (GO:0035329)2.61063198
155regulation of viral release from host cell (GO:1902186)2.61052276
156extracellular matrix assembly (GO:0085029)2.60968644
157negative regulation of protein localization to plasma membrane (GO:1903077)2.60690135
158cellular response to growth hormone stimulus (GO:0071378)2.60464309
159negative regulation of cell size (GO:0045792)2.60011901
160negative regulation of smooth muscle cell migration (GO:0014912)2.59852407
161cell adhesion mediated by integrin (GO:0033627)2.59791453
162multicellular organismal macromolecule metabolic process (GO:0044259)2.58937076
163cell migration involved in sprouting angiogenesis (GO:0002042)2.57057582
164collagen metabolic process (GO:0032963)2.57028178
165cellular response to vitamin (GO:0071295)2.56466180
166regulation of macrophage chemotaxis (GO:0010758)2.56035133
167negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.55882956
168carnitine transmembrane transport (GO:1902603)2.54215072
169insulin-like growth factor receptor signaling pathway (GO:0048009)2.53837068
170multicellular organismal metabolic process (GO:0044236)2.53803094
171lung vasculature development (GO:0060426)2.52690309
172fatty acid oxidation (GO:0019395)2.52370067
173adherens junction assembly (GO:0034333)2.51758390
174bundle of His cell to Purkinje myocyte communication (GO:0086069)2.51374290
175negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.51335470
176chondrocyte proliferation (GO:0035988)2.50610996
177positive regulation of lipid catabolic process (GO:0050996)2.48097345
178negative regulation of DNA biosynthetic process (GO:2000279)2.47544530
179triglyceride biosynthetic process (GO:0019432)2.47277307
180blood vessel endothelial cell migration (GO:0043534)2.46587993
181adhesion of symbiont to host (GO:0044406)2.45790868
182lipid oxidation (GO:0034440)2.45453185
183outflow tract septum morphogenesis (GO:0003148)2.44752358
1842-oxoglutarate metabolic process (GO:0006103)2.40701736
185lymphangiogenesis (GO:0001946)2.40399900
186acylglycerol biosynthetic process (GO:0046463)2.39859649
187neutral lipid biosynthetic process (GO:0046460)2.39859649
188positive regulation of glucose import (GO:0046326)2.39687037
189positive regulation of cellular response to insulin stimulus (GO:1900078)2.39603061
190positive regulation of endothelial cell differentiation (GO:0045603)2.38223845
191alpha-linolenic acid metabolic process (GO:0036109)2.37423476

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.16448372
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.23776723
3CLOCK_20551151_ChIP-Seq_293T_Human4.61756832
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.98251433
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.33216307
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.25186950
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.07415808
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.86837893
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.61168602
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.41191410
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.40282315
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.38735579
13ESR1_15608294_ChIP-ChIP_MCF-7_Human2.26577980
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.26448790
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18031605
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.16764895
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.09049909
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.98959202
19CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.97666925
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.96851639
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.94475724
22TBX20_22080862_ChIP-Seq_HEART_Mouse1.93605191
23TBX20_22328084_ChIP-Seq_HEART_Mouse1.93605191
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.90898067
25GATA1_22025678_ChIP-Seq_K562_Human1.83881707
26PPAR_26484153_Chip-Seq_NCI-H1993_Human1.77619269
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74812568
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72709670
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.69245297
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.69116514
31SMC4_20622854_ChIP-Seq_HELA_Human1.65141991
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58421634
33CJUN_26792858_Chip-Seq_BT549_Human1.56955412
34GATA6_25053715_ChIP-Seq_YYC3_Human1.56277507
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55450074
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.55123820
37ZNF263_19887448_ChIP-Seq_K562_Human1.54917234
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54176343
39SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51891480
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51015841
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49806126
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49192229
43KLF5_25053715_ChIP-Seq_YYC3_Human1.46665981
44RACK7_27058665_Chip-Seq_MCF-7_Human1.46410739
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43800667
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43318710
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43144953
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42598547
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41517195
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.40858799
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.39785149
52LXR_22292898_ChIP-Seq_THP-1_Human1.39309253
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38879222
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.38484231
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.38287813
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37978820
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35458712
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34721248
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33147161
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33078928
61* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28436256
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27608443
63* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.25707896
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24411240
65P68_20966046_ChIP-Seq_HELA_Human1.23974949
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23712535
67ELF5_23300383_ChIP-Seq_T47D_Human1.23577297
68* SOX2_20726797_ChIP-Seq_SW620_Human1.22752752
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21679841
70ATF3_27146783_Chip-Seq_COLON_Human1.20709844
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20461167
72CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19378002
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19110370
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18192143
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18158610
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17979231
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15331393
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.15238755
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11864034
80* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.11344848
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11132920
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11132920
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10334876
84EOMES_21245162_ChIP-Seq_HESCs_Human1.09507797
85ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08043976
86CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07739163
87KDM2B_26808549_Chip-Seq_K562_Human1.07598077
88* RARB_24833708_ChIP-Seq_LIVER_Mouse1.07442580
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.06801875
90AHR_22903824_ChIP-Seq_MCF-7_Human1.06290107
91CTCF_27219007_Chip-Seq_Bcells_Human1.06016701
92GATA1_19941826_ChIP-Seq_K562_Human1.05947524
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05686431
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05403326
95CREB1_26743006_Chip-Seq_LNCaP_Human1.05321894
96KDM5A_27292631_Chip-Seq_BREAST_Human1.04891272
97* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04171860
98BRD4_25478319_ChIP-Seq_HGPS_Human1.04043810
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03409892
100P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02724692
101* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02575800
102NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02456408
103FOXM1_23109430_ChIP-Seq_U2OS_Human1.02406614
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02278497
105FOXA2_19822575_ChIP-Seq_HepG2_Human1.01593021
106* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01124870
107SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00660886
108KDM2B_26808549_Chip-Seq_DND41_Human1.00601281
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00597988
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00476047
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99222324
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98949485
113MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98835431
114CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98628496
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98192770
116* RUNX1_27514584_Chip-Seq_MCF-7_Human0.97868473
117CDX2_20551321_ChIP-Seq_CACO-2_Human0.97435987
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96346292
119SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95682036
120JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95250422
121BCL6_27268052_Chip-Seq_Bcells_Human0.94869576
122* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.94067236
123UBF1/2_26484160_Chip-Seq_HMECs_Human0.93839895
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93386106
125MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93337931
126TP53_20018659_ChIP-ChIP_R1E_Mouse0.93247132
127STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93035087
128ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92919212
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92886886
130PHF8_20622854_ChIP-Seq_HELA_Human0.92861196
131TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91841191
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91780331
133CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91275350
134TP53_22127205_ChIP-Seq_IMR90_Human0.91216453
135SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.90933925
136RNF2_18974828_ChIP-Seq_MESCs_Mouse0.89650965
137EZH2_18974828_ChIP-Seq_MESCs_Mouse0.89650965
138ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89517255
139* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87261560
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87012639
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86130783
142FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85681994
143NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85130796
144NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85130796
145GATA4_25053715_ChIP-Seq_YYC3_Human0.85059221
146SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.84896387
147GATA3_24758297_ChIP-Seq_MCF-7_Human0.84490690
148CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84166736
149* TP63_22573176_ChIP-Seq_HFKS_Human0.83316733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.59838103
2MP0010234_abnormal_vibrissa_follicle3.64913105
3MP0005275_abnormal_skin_tensile3.60910500
4MP0003705_abnormal_hypodermis_morpholog3.38939350
5MP0004272_abnormal_basement_membrane3.35489690
6MP0005670_abnormal_white_adipose3.25969923
7MP0002796_impaired_skin_barrier3.14949794
8MP0002837_dystrophic_cardiac_calcinosis3.12986724
9MP0001958_emphysema3.08302143
10MP0004264_abnormal_extraembryonic_tissu3.05021648
11MP0005058_abnormal_lysosome_morphology2.86748537
12MP0000678_abnormal_parathyroid_gland2.71537642
13MP0000566_synostosis2.64583907
14MP0004130_abnormal_muscle_cell2.58455812
15MP0004185_abnormal_adipocyte_glucose2.50822909
16MP0003566_abnormal_cell_adhesion2.49479837
17MP0005666_abnormal_adipose_tissue2.48572758
18MP0005501_abnormal_skin_physiology2.45180969
19MP0004084_abnormal_cardiac_muscle2.44705033
20MP0005503_abnormal_tendon_morphology2.40793253
21MP0010030_abnormal_orbit_morphology2.40540615
22MP0003942_abnormal_urinary_system2.39104001
23MP0004233_abnormal_muscle_weight2.38636531
24MP0010368_abnormal_lymphatic_system2.33545905
25MP0006138_congestive_heart_failure2.19111971
26MP0005623_abnormal_meninges_morphology2.14776199
27MP0003279_aneurysm2.08874080
28MP0000013_abnormal_adipose_tissue1.98831042
29MP0002249_abnormal_larynx_morphology1.98814969
30MP0003828_pulmonary_edema1.97943692
31MP0002098_abnormal_vibrissa_morphology1.97792098
32MP0005375_adipose_tissue_phenotype1.95302993
33MP0003453_abnormal_keratinocyte_physiol1.93338801
34MP0010352_gastrointestinal_tract_polyps1.87140290
35MP0000751_myopathy1.86339551
36MP0008260_abnormal_autophagy1.81261460
37MP0005083_abnormal_biliary_tract1.74660195
38MP0006054_spinal_hemorrhage1.72105533
39MP0009384_cardiac_valve_regurgitation1.69005588
40MP0005330_cardiomyopathy1.66056158
41MP0003191_abnormal_cellular_cholesterol1.63125849
42MP0008775_abnormal_heart_ventricle1.62354248
43MP0001849_ear_inflammation1.61981762
44MP0004036_abnormal_muscle_relaxation1.58316017
45MP0002254_reproductive_system_inflammat1.57549698
46MP0001544_abnormal_cardiovascular_syste1.56142474
47MP0005385_cardiovascular_system_phenoty1.56142474
48MP0002295_abnormal_pulmonary_circulatio1.56100148
49MP0004019_abnormal_vitamin_homeostasis1.53701474
50MP0001879_abnormal_lymphatic_vessel1.53257076
51MP0010329_abnormal_lipoprotein_level1.48379004
52MP0000003_abnormal_adipose_tissue1.47609985
53MP0001873_stomach_inflammation1.46759649
54MP0001216_abnormal_epidermal_layer1.45863675
55MP0010771_integument_phenotype1.41859966
56MP0000516_abnormal_urinary_system1.40873125
57MP0005367_renal/urinary_system_phenotyp1.40873125
58MP0005023_abnormal_wound_healing1.40639058
59MP0010678_abnormal_skin_adnexa1.40588264
60MP0002736_abnormal_nociception_after1.38956190
61MP0000750_abnormal_muscle_regeneration1.35265327
62MP0004087_abnormal_muscle_fiber1.33576215
63MP0002972_abnormal_cardiac_muscle1.32847088
64MP0003385_abnormal_body_wall1.31364450
65MP0005620_abnormal_muscle_contractility1.29930408
66MP0000767_abnormal_smooth_muscle1.29203942
67MP0003936_abnormal_reproductive_system1.29027057
68MP0010630_abnormal_cardiac_muscle1.24638565
69MP0000467_abnormal_esophagus_morphology1.24026484
70MP0003950_abnormal_plasma_membrane1.23351886
71MP0009115_abnormal_fat_cell1.22793858
72MP0003091_abnormal_cell_migration1.22517832
73MP0002971_abnormal_brown_adipose1.22155955
74MP0003878_abnormal_ear_physiology1.20454404
75MP0005377_hearing/vestibular/ear_phenot1.20454404
76MP0000462_abnormal_digestive_system1.20241950
77MP0001664_abnormal_digestion1.18959596
78MP0003806_abnormal_nucleotide_metabolis1.16952655
79MP0004215_abnormal_myocardial_fiber1.16620263
80MP0000383_abnormal_hair_follicle1.16186766
81MP0003943_abnormal_hepatobiliary_system1.15557183
82MP0000343_altered_response_to1.15089274
83MP0002909_abnormal_adrenal_gland1.14906917
84MP0003115_abnormal_respiratory_system1.13343308
85MP0003786_premature_aging1.11226915
86MP0002133_abnormal_respiratory_system1.08928665
87MP0005388_respiratory_system_phenotype1.08928665
88MP0008932_abnormal_embryonic_tissue1.07788980
89MP0005508_abnormal_skeleton_morphology1.07670761
90MP0005167_abnormal_blood-brain_barrier1.07105565
91MP0004782_abnormal_surfactant_physiolog1.05976527
92MP0008004_abnormal_stomach_pH1.04691295
93MP0003567_abnormal_fetal_cardiomyocyte1.04551305
94MP0000627_abnormal_mammary_gland1.04240692
95MP0001756_abnormal_urination1.03756890
96MP0002060_abnormal_skin_morphology1.02725558
97MP0000377_abnormal_hair_follicle1.02436226
98MP0002128_abnormal_blood_circulation1.01816015
99MP0009780_abnormal_chondrocyte_physiolo1.01176031
100MP0000534_abnormal_ureter_morphology0.98530136
101MP0005164_abnormal_response_to0.97260860
102MP0000537_abnormal_urethra_morphology0.95994631
103MP0001727_abnormal_embryo_implantation0.95630474
104MP0002118_abnormal_lipid_homeostasis0.95434551
105MP0003045_fibrosis0.95370216
106MP0000733_abnormal_muscle_development0.94996572
107MP0009931_abnormal_skin_appearance0.94714157
108MP0005334_abnormal_fat_pad0.93839844
109MP0000249_abnormal_blood_vessel0.92538638
110MP0002135_abnormal_kidney_morphology0.92459192
111MP0003638_abnormal_response/metabolism_0.91237717
112MP0002108_abnormal_muscle_morphology0.91008138
113MP0001661_extended_life_span0.90920615
114MP0005076_abnormal_cell_differentiation0.90440514
115MP0005595_abnormal_vascular_smooth0.89615460
116MP0001614_abnormal_blood_vessel0.88294078
117MP0002168_other_aberrant_phenotype0.85695417
118MP0003941_abnormal_skin_development0.85581538
119MP0005365_abnormal_bile_salt0.85579793
120MP0005408_hypopigmentation0.85419327
121MP0003724_increased_susceptibility_to0.84619383
122MP0001881_abnormal_mammary_gland0.83779547
123MP0000759_abnormal_skeletal_muscle0.83104364
124MP0002139_abnormal_hepatobiliary_system0.82960401
125MP0002136_abnormal_kidney_physiology0.82503117
126MP0002970_abnormal_white_adipose0.79428174
127MP0005332_abnormal_amino_acid0.78806512
128MP0000266_abnormal_heart_morphology0.78672755
129MP0000858_altered_metastatic_potential0.78250875
130MP0002925_abnormal_cardiovascular_devel0.77742148
131MP0003866_abnormal_defecation0.77090482
132MP0002086_abnormal_extraembryonic_tissu0.76910561
133MP0000762_abnormal_tongue_morphology0.76592701
134MP0001175_abnormal_lung_morphology0.76499697
135MP0009643_abnormal_urine_homeostasis0.76370060
136MP0009053_abnormal_anal_canal0.75929828
137MP0010386_abnormal_urinary_bladder0.73763699
138MP0000465_gastrointestinal_hemorrhage0.73502165
139MP0004883_abnormal_blood_vessel0.73376583
140MP0005360_urolithiasis0.73248634
141MP0000639_abnormal_adrenal_gland0.72801754
142MP0003938_abnormal_ear_development0.72201484
143MP0003221_abnormal_cardiomyocyte_apopto0.71169905
144MP0001853_heart_inflammation0.69918389
145MP0003283_abnormal_digestive_organ0.69743596
146MP0003959_abnormal_lean_body0.68739162
147MP0005257_abnormal_intraocular_pressure0.68172646
148MP0005165_increased_susceptibility_to0.67139684
149MP0008875_abnormal_xenobiotic_pharmacok0.65129286
150MP0000609_abnormal_liver_physiology0.64532892
151MP0001697_abnormal_embryo_size0.64389375
152MP0004484_altered_response_of0.64088951
153MP0002080_prenatal_lethality0.63706795
154MP0004085_abnormal_heartbeat0.63520803
155MP0004947_skin_inflammation0.63307437
156MP0002269_muscular_atrophy0.63245212
157MP0003137_abnormal_impulse_conducting0.62843324
158MP0002106_abnormal_muscle_physiology0.62556083
159MP0002127_abnormal_cardiovascular_syste0.62114688
160MP0000477_abnormal_intestine_morphology0.61864352
161MP0003879_abnormal_hair_cell0.58734551
162MP0005248_abnormal_Harderian_gland0.58690751
163MP0003693_abnormal_embryo_hatching0.57845982
164MP0002085_abnormal_embryonic_tissue0.57147600
165MP0003984_embryonic_growth_retardation0.55563664
166MP0002088_abnormal_embryonic_growth/wei0.54936113

Predicted human phenotypes

RankGene SetZ-score
1Focal segmental glomerulosclerosis (HP:0000097)5.56411886
2Premature rupture of membranes (HP:0001788)5.53991332
3Glomerulosclerosis (HP:0000096)5.07475939
4Protrusio acetabuli (HP:0003179)5.00755342
5Ankle contracture (HP:0006466)4.94879419
6Cerebral aneurysm (HP:0004944)4.59740373
7Aortic aneurysm (HP:0004942)4.46985302
8Aortic dissection (HP:0002647)4.43767826
9Right ventricular cardiomyopathy (HP:0011663)4.29276390
10Broad metatarsal (HP:0001783)4.02727485
11Shallow orbits (HP:0000586)3.94303395
12Abnormality of the distal phalanges of the toes (HP:0010182)3.63293060
13Increased connective tissue (HP:0009025)3.60461205
14Tubulointerstitial fibrosis (HP:0005576)3.52147202
15Trismus (HP:0000211)3.49646040
16Muscle fiber splitting (HP:0003555)3.47112554
17Anomalous pulmonary venous return (HP:0010772)3.30945300
18Tubular atrophy (HP:0000092)3.27545329
19Acanthosis nigricans (HP:0000956)3.26331987
20Osteomalacia (HP:0002749)3.18667524
21Distal lower limb muscle weakness (HP:0009053)3.18224993
22Distal lower limb amyotrophy (HP:0008944)3.15233113
23Short nail (HP:0001799)3.14830208
24Hypokinesia (HP:0002375)3.13715848
25Aneurysm (HP:0002617)3.09596945
26Progressive sensorineural hearing impairment (HP:0000408)3.07282997
27Ventricular tachycardia (HP:0004756)3.02020068
28Seborrheic dermatitis (HP:0001051)3.00830718
29Oligomenorrhea (HP:0000876)2.99353885
30Long toe (HP:0010511)2.95764100
31Truncus arteriosus (HP:0001660)2.93349825
32Hypoparathyroidism (HP:0000829)2.92488867
33Sudden death (HP:0001699)2.89701362
34Type 1 muscle fiber predominance (HP:0003803)2.87985059
35Mitral valve prolapse (HP:0001634)2.87965174
36Dilatation of the ascending aorta (HP:0005111)2.87388587
37Complement deficiency (HP:0004431)2.85694141
38Micronodular cirrhosis (HP:0001413)2.84999342
39Polycythemia (HP:0001901)2.83261889
40Spinal rigidity (HP:0003306)2.81913291
41Lipoatrophy (HP:0100578)2.81055677
42Abnormality of the pulmonary veins (HP:0011718)2.77646152
43Peritonitis (HP:0002586)2.77620588
44Atelectasis (HP:0100750)2.76108722
45Increased variability in muscle fiber diameter (HP:0003557)2.73343552
46Shoulder girdle muscle weakness (HP:0003547)2.71602410
47Hyporeflexia of lower limbs (HP:0002600)2.68658841
48Ulnar bowing (HP:0003031)2.68166901
49Hyperthyroidism (HP:0000836)2.67141151
50Hyperacusis (HP:0010780)2.66236682
51Pili torti (HP:0003777)2.65523820
52Bladder diverticulum (HP:0000015)2.61689072
53Soft skin (HP:0000977)2.59895986
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.58880407
55Osteolytic defects of the hand bones (HP:0009699)2.58880407
56Congenital ichthyosiform erythroderma (HP:0007431)2.57039659
57Hypotrichosis (HP:0001006)2.51791602
58Atrophic scars (HP:0001075)2.51652257
59Camptodactyly of toe (HP:0001836)2.51501344
60Entropion (HP:0000621)2.50137831
61Curly hair (HP:0002212)2.48518189
62Hematochezia (HP:0002573)2.46037800
63Testicular atrophy (HP:0000029)2.45497624
64Progressive hearing impairment (HP:0001730)2.44338434
65Deep venous thrombosis (HP:0002625)2.43128197
66Distal upper limb amyotrophy (HP:0007149)2.42778408
67Upper limb amyotrophy (HP:0009129)2.42778408
68Abnormal hemoglobin (HP:0011902)2.42578055
69Hypertriglyceridemia (HP:0002155)2.42326738
70Glucose intolerance (HP:0000833)2.41743338
71Difficulty running (HP:0009046)2.40911216
72Abdominal distention (HP:0003270)2.40428017
73Rectal prolapse (HP:0002035)2.40216052
74Mesangial abnormality (HP:0001966)2.38152920
75Wrist flexion contracture (HP:0001239)2.37687746
76Centrally nucleated skeletal muscle fibers (HP:0003687)2.37111460
77Limb-girdle muscle atrophy (HP:0003797)2.34971720
78Blue sclerae (HP:0000592)2.34144862
79Poikiloderma (HP:0001029)2.33900161
80Mucopolysacchariduria (HP:0008155)2.33710099
81Urinary glycosaminoglycan excretion (HP:0003541)2.33710099
82Fragile skin (HP:0001030)2.30086494
83Abnormality of the umbilical cord (HP:0010881)2.29965977
84Abnormal cartilage morphology (HP:0002763)2.29505382
85Lymphangioma (HP:0100764)2.28573023
86Abnormal ventriculo-arterial connection (HP:0011563)2.28225988
87Transposition of the great arteries (HP:0001669)2.28225988
88Abnormal connection of the cardiac segments (HP:0011545)2.28225988
89Axonal loss (HP:0003447)2.27268359
90Abnormality of skeletal muscle fiber size (HP:0012084)2.26276983
91Abnormal trabecular bone morphology (HP:0100671)2.26192501
92Hypoplastic left heart (HP:0004383)2.23497416
93Asymmetry of the thorax (HP:0001555)2.23163450
94Germ cell neoplasia (HP:0100728)2.19385522
95Abnormality of the 4th metacarpal (HP:0010012)2.16981522
96Testicular neoplasm (HP:0010788)2.16583484
97Atrial fibrillation (HP:0005110)2.16516494
98Abnormality of small intestinal villus morphology (HP:0011472)2.14722035
99Villous atrophy (HP:0011473)2.14722035
100Follicular hyperkeratosis (HP:0007502)2.12982741
101Multiple enchondromatosis (HP:0005701)2.12906902
102Abnormality of liposaccharide metabolism (HP:0010968)2.12489302
103Abnormality of glycosphingolipid metabolism (HP:0004343)2.12489302
104Abnormality of glycolipid metabolism (HP:0010969)2.12489302
105Mildly elevated creatine phosphokinase (HP:0008180)2.11836054
106Abnormality of dentin (HP:0010299)2.11080415
107Scapular winging (HP:0003691)2.08772160
108Wormian bones (HP:0002645)2.08621994
109Abnormality of complement system (HP:0005339)2.08370062
110Overlapping toe (HP:0001845)2.08182765
111Pulmonary artery stenosis (HP:0004415)2.07605086
112Gastrointestinal dysmotility (HP:0002579)2.06324657
113Venous abnormality (HP:0002624)2.06101005
114Abnormal hair laboratory examination (HP:0003328)2.05351288
115Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03858423
116Abnormality of polysaccharide metabolism (HP:0011012)2.03858423
117Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03858423
118Visceral angiomatosis (HP:0100761)2.03626755
119Spastic paraparesis (HP:0002313)2.03526019
120Interstitial pulmonary disease (HP:0006530)2.03515337
121Stridor (HP:0010307)2.03505600
122Supraventricular arrhythmia (HP:0005115)2.03304316
123Bowing of the arm (HP:0006488)2.02761369
124Bowed forearm bones (HP:0003956)2.02761369
125Striae distensae (HP:0001065)2.02313580
126Primary atrial arrhythmia (HP:0001692)2.02045753
127Alopecia of scalp (HP:0002293)2.01764268
128Esophageal varix (HP:0002040)2.01270622
129Buphthalmos (HP:0000557)2.00171082
130Bone pain (HP:0002653)1.99729543
131Cervical subluxation (HP:0003308)1.98963616
132Systemic lupus erythematosus (HP:0002725)1.96758592
133Reduced subcutaneous adipose tissue (HP:0003758)1.96644024
134Growth hormone excess (HP:0000845)1.96318277
135Stage 5 chronic kidney disease (HP:0003774)1.96286484
136Atrioventricular block (HP:0001678)1.95805470
137Elbow flexion contracture (HP:0002987)1.94845641
138Delayed epiphyseal ossification (HP:0002663)1.94529137
139Tubulointerstitial abnormality (HP:0001969)1.94232719
140Abnormality of the fetal cardiovascular system (HP:0010948)1.92975562
141Abnormal umbilical cord blood vessels (HP:0011403)1.92975562
142Single umbilical artery (HP:0001195)1.92975562
143Supraventricular tachycardia (HP:0004755)1.90175749
144Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89462713
145Cerebral palsy (HP:0100021)1.89253638
146Thin bony cortex (HP:0002753)1.89155779
147Ectopia lentis (HP:0001083)1.88404115
148Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.87760188
149Bronchomalacia (HP:0002780)1.87399858
150Down-sloping shoulders (HP:0200021)1.85632720
151Tongue fasciculations (HP:0001308)1.84807623
152Vertebral compression fractures (HP:0002953)1.84385488
153Venous insufficiency (HP:0005293)1.84126862
154Hyperextensible skin (HP:0000974)1.83953520
155Hemangiomatosis (HP:0007461)1.83896994
156Asymmetric septal hypertrophy (HP:0001670)1.83586196
157Vascular tortuosity (HP:0004948)1.83350864
158Flexion contracture of toe (HP:0005830)1.83251975
159Joint contractures involving the joints of the feet (HP:0100492)1.83251975
160Ragged-red muscle fibers (HP:0003200)1.82716530
161Rough bone trabeculation (HP:0100670)1.82494068
162Pelvic girdle muscle weakness (HP:0003749)1.82333305
163Hyperglycinuria (HP:0003108)1.82225488
164Enlarged penis (HP:0000040)1.82077074
165Wide anterior fontanel (HP:0000260)1.81176506
166Neonatal death (HP:0003811)1.79648309
167Abnormal delivery (HP:0001787)1.79324164
168Hemorrhage of the eye (HP:0011885)1.78717715
169Joint laxity (HP:0001388)1.77347191
170Bone cyst (HP:0012062)1.77253798
171Gonadal dysgenesis (HP:0000133)1.76799778
172Ependymoma (HP:0002888)1.76369610
173Selective tooth agenesis (HP:0001592)1.75469628
174Patellar dislocation (HP:0002999)1.75459495
175Hypoplastic heart (HP:0001961)1.75388461
176Patent foramen ovale (HP:0001655)1.75138626
177Median cleft lip (HP:0000161)1.74635382
178Amelogenesis imperfecta (HP:0000705)1.74442918
179Facial diplegia (HP:0001349)1.73054513
180Ureteral duplication (HP:0000073)1.72528994
181Palpitations (HP:0001962)1.72522549
182Lower limb amyotrophy (HP:0007210)1.71134547
183Exercise-induced myalgia (HP:0003738)1.70392351
184Cardiomegaly (HP:0001640)1.68608618
185Dysostosis multiplex (HP:0000943)1.67866993
186Abnormality of the vocal cords (HP:0008777)1.67484255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.70574905
2TTN4.83399837
3MYLK3.72910761
4PKN23.06635162
5EPHB22.91759919
6TIE12.88698294
7RIPK12.71247302
8MAP3K122.69833606
9CAMK1D2.61279089
10LMTK22.58337921
11ERN12.53278413
12MST1R2.42775476
13MST42.34321456
14PDGFRA2.24470217
15RPS6KB22.21012294
16LATS12.17785556
17TGFBR22.04080537
18SIK12.02926746
19CAMK1G1.87704135
20NME11.87565469
21BCKDK1.84126830
22IRAK31.83361420
23DMPK1.83139859
24DDR21.82504185
25ILK1.79386019
26BRSK21.73142661
27NME21.68946981
28LRRK21.67335511
29LATS21.65911940
30MET1.58543247
31PAK21.51024178
32PTK61.42953848
33FER1.41662116
34BRSK11.40739773
35MAP2K21.29542264
36SMG11.28872483
37CAMKK21.28504021
38TESK21.24442875
39PAK41.23492832
40PDK41.21075926
41PDK31.21075926
42PAK31.19734046
43CDK81.16524445
44PIK3CA1.15362702
45EPHB11.12723108
46MUSK1.11523660
47BUB11.08797881
48FGFR41.08101255
49EIF2AK11.04603190
50DAPK31.02844912
51PTK2B1.02168475
52DAPK11.01424127
53NEK91.00902390
54ZAP700.99174011
55MAP3K20.96528586
56PBK0.95995790
57VRK20.94734226
58PHKG10.93557754
59PHKG20.93557754
60PRKD10.93124398
61PTK20.91186037
62KDR0.86859747
63EEF2K0.85119539
64CAMK2G0.82913430
65ROCK10.80399598
66PRKCI0.79881738
67FGFR20.79792964
68STK380.78026323
69MAP2K10.76779745
70MAP2K30.75722504
71MTOR0.75561631
72TESK10.74696805
73PDGFRB0.74069892
74TBK10.73549523
75TRPM70.72283871
76PRKAA20.70650231
77BMX0.69275956
78CDK60.68864051
79RET0.68811727
80CAMK2B0.67157007
81TGFBR10.66146689
82NLK0.64718073
83MAPKAPK20.64224946
84CDC42BPA0.63006451
85STK100.61579296
86MAP3K30.61309557
87PDK20.58264826
88ARAF0.58175283
89STK38L0.57948364
90AURKB0.56362356
91STK30.55983347
92CSK0.54951500
93ROCK20.54229616
94FGFR30.50574973
95LIMK10.49891346
96STK240.49607903
97PRKD30.48222799
98PRKD20.48042986
99CDK40.47886142
100GSK3A0.47619768
101PRKCH0.46936168
102MAP2K60.45672997
103PIM20.45430022
104PIK3CG0.44615881
105MAP3K110.44346636
106CDK90.42758972
107EPHA30.42706093
108ERBB20.42139065
109PAK10.42024864
110BMPR20.41361918
111IRAK20.41215917
112PDPK10.40561821
113PRKG20.40488349
114FGFR10.40309821
115MAP3K70.39261485
116MAPKAPK30.39182184
117IRAK10.38787799
118ABL20.38725972
119SRC0.37804777
120MAP3K60.37002196
121MELK0.36892678
122RPS6KA20.36669294
123NTRK10.36219387
124KSR20.35930890
125CDK70.35820476
126RPS6KC10.34944850
127RPS6KL10.34944850
128MAP3K10.34667696
129JAK10.33500110
130MAPK120.33072033
131CAMKK10.31995264
132CAMK2D0.31054798
133MAP3K100.29915202
134RPS6KA60.29677149
135SCYL20.29448202
136MAP4K10.29295915
137WNK10.28785333
138TAOK20.28590283
139FLT30.28251214
140MAP3K80.27570456
141CHUK0.27189353
142JAK20.27103596
143IGF1R0.26048642
144CAMK10.26031457
145PRKAA10.25716778
146INSR0.25416887
147EPHA20.25188509
148IRAK40.24919230
149CLK10.22084630
150RPS6KA40.21720223
151PRKCD0.18185948
152CDK120.18064045
153IKBKB0.17806802

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.12631324
2Proteasome_Homo sapiens_hsa030503.94693477
3Other glycan degradation_Homo sapiens_hsa005113.37488539
4PPAR signaling pathway_Homo sapiens_hsa033202.97516924
5Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.87847884
6Folate biosynthesis_Homo sapiens_hsa007902.83244942
7ECM-receptor interaction_Homo sapiens_hsa045122.77280490
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.73034657
9Propanoate metabolism_Homo sapiens_hsa006402.68045960
10Fatty acid degradation_Homo sapiens_hsa000712.59641431
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.57926267
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44234189
13Fatty acid metabolism_Homo sapiens_hsa012122.43441951
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.43179053
15Fatty acid biosynthesis_Homo sapiens_hsa000612.36703995
16Thyroid cancer_Homo sapiens_hsa052162.27426550
17Base excision repair_Homo sapiens_hsa034102.13798779
18Focal adhesion_Homo sapiens_hsa045102.10245232
19Galactose metabolism_Homo sapiens_hsa000522.05090985
20Dilated cardiomyopathy_Homo sapiens_hsa054141.81596796
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.77964335
22Glycerolipid metabolism_Homo sapiens_hsa005611.64942433
23Adipocytokine signaling pathway_Homo sapiens_hsa049201.59322752
24Nitrogen metabolism_Homo sapiens_hsa009101.57373609
25Pyruvate metabolism_Homo sapiens_hsa006201.57246070
26beta-Alanine metabolism_Homo sapiens_hsa004101.54904818
27N-Glycan biosynthesis_Homo sapiens_hsa005101.49204811
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.48883779
29Mismatch repair_Homo sapiens_hsa034301.48809012
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48053937
31Complement and coagulation cascades_Homo sapiens_hsa046101.45228424
32Caffeine metabolism_Homo sapiens_hsa002321.44696501
33Staphylococcus aureus infection_Homo sapiens_hsa051501.43517114
34Sulfur metabolism_Homo sapiens_hsa009201.41332834
35Proteoglycans in cancer_Homo sapiens_hsa052051.40044268
36AMPK signaling pathway_Homo sapiens_hsa041521.39676456
37Amoebiasis_Homo sapiens_hsa051461.36732503
38Carbon metabolism_Homo sapiens_hsa012001.35495084
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34918415
40Arachidonic acid metabolism_Homo sapiens_hsa005901.33646833
41Tryptophan metabolism_Homo sapiens_hsa003801.33099098
42Bladder cancer_Homo sapiens_hsa052191.30088417
43Fat digestion and absorption_Homo sapiens_hsa049751.28312451
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27847758
45Protein digestion and absorption_Homo sapiens_hsa049741.26716026
46Adherens junction_Homo sapiens_hsa045201.25935110
47Small cell lung cancer_Homo sapiens_hsa052221.23566821
48Insulin resistance_Homo sapiens_hsa049311.22257632
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.20498021
50Tight junction_Homo sapiens_hsa045301.20099725
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18364608
52Phenylalanine metabolism_Homo sapiens_hsa003601.16786954
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.16318043
54Nucleotide excision repair_Homo sapiens_hsa034201.13533240
55Sphingolipid metabolism_Homo sapiens_hsa006001.12754525
56Hippo signaling pathway_Homo sapiens_hsa043901.06467532
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04935848
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04031144
59Vibrio cholerae infection_Homo sapiens_hsa051101.03810371
60mTOR signaling pathway_Homo sapiens_hsa041501.01592788
61Viral myocarditis_Homo sapiens_hsa054161.00637565
62Fructose and mannose metabolism_Homo sapiens_hsa000510.99076636
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97740190
64Salmonella infection_Homo sapiens_hsa051320.97112385
65Tyrosine metabolism_Homo sapiens_hsa003500.96666899
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96116681
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95535201
68DNA replication_Homo sapiens_hsa030300.95424589
69Arginine biosynthesis_Homo sapiens_hsa002200.94800212
70TGF-beta signaling pathway_Homo sapiens_hsa043500.93584378
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92793783
72Insulin signaling pathway_Homo sapiens_hsa049100.92036208
73Hepatitis C_Homo sapiens_hsa051600.91368156
74Basal cell carcinoma_Homo sapiens_hsa052170.91291152
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.89924022
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88753513
77Butanoate metabolism_Homo sapiens_hsa006500.87268302
78Acute myeloid leukemia_Homo sapiens_hsa052210.86884712
79Endocytosis_Homo sapiens_hsa041440.86637224
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85216617
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.84915435
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82703672
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80434828
84Pyrimidine metabolism_Homo sapiens_hsa002400.79884646
85Peroxisome_Homo sapiens_hsa041460.77570546
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76947820
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76834135
88Platelet activation_Homo sapiens_hsa046110.76388519
89Notch signaling pathway_Homo sapiens_hsa043300.75949595
90Shigellosis_Homo sapiens_hsa051310.75923213
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75846478
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72319570
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71798390
94Regulation of autophagy_Homo sapiens_hsa041400.71477007
95Ovarian steroidogenesis_Homo sapiens_hsa049130.70860268
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70737788
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69923229
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69912499
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.66814936
100Chemical carcinogenesis_Homo sapiens_hsa052040.65490803
101Glucagon signaling pathway_Homo sapiens_hsa049220.63972806
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63735535
103Lysine degradation_Homo sapiens_hsa003100.61527810
104Fatty acid elongation_Homo sapiens_hsa000620.61133990
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60708016
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60100766
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58237828
108Chronic myeloid leukemia_Homo sapiens_hsa052200.56582758
109Endometrial cancer_Homo sapiens_hsa052130.56304469
110Renin secretion_Homo sapiens_hsa049240.56295308
111Histidine metabolism_Homo sapiens_hsa003400.56295072
112Steroid biosynthesis_Homo sapiens_hsa001000.55882866
113Legionellosis_Homo sapiens_hsa051340.54489297
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54056355
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53905068
116Hedgehog signaling pathway_Homo sapiens_hsa043400.53251787
117Pertussis_Homo sapiens_hsa051330.53064993
118Bile secretion_Homo sapiens_hsa049760.52757607
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52699894
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50127660
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.50027539
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49740409
123Toxoplasmosis_Homo sapiens_hsa051450.49730596
124Pathways in cancer_Homo sapiens_hsa052000.49101696
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47951499
126Homologous recombination_Homo sapiens_hsa034400.47895673
127Choline metabolism in cancer_Homo sapiens_hsa052310.47689890
128MicroRNAs in cancer_Homo sapiens_hsa052060.47160267
129Pancreatic cancer_Homo sapiens_hsa052120.47115213
130Rap1 signaling pathway_Homo sapiens_hsa040150.46361862
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.46335832
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45623434
133Melanoma_Homo sapiens_hsa052180.44574101
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43367871
135Biosynthesis of amino acids_Homo sapiens_hsa012300.43336569
136Pentose phosphate pathway_Homo sapiens_hsa000300.43312822
137Glutathione metabolism_Homo sapiens_hsa004800.42046981
138Cardiac muscle contraction_Homo sapiens_hsa042600.41894600
139Axon guidance_Homo sapiens_hsa043600.41064461
140Renal cell carcinoma_Homo sapiens_hsa052110.41041419
141Melanogenesis_Homo sapiens_hsa049160.40026757
142HIF-1 signaling pathway_Homo sapiens_hsa040660.39487062
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39435844
144Malaria_Homo sapiens_hsa051440.38994455
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38876050
146VEGF signaling pathway_Homo sapiens_hsa043700.38740361
147Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38733659
148Retinol metabolism_Homo sapiens_hsa008300.37401500
149Metabolic pathways_Homo sapiens_hsa011000.37372513
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.34619569
151Prolactin signaling pathway_Homo sapiens_hsa049170.34429718
152Lysosome_Homo sapiens_hsa041420.34339190
153Vitamin B6 metabolism_Homo sapiens_hsa007500.34038575
154Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33088047

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