UPK3BL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)7.92412901
2retinal metabolic process (GO:0042574)7.03013910
3cell wall macromolecule catabolic process (GO:0016998)6.36872212
4cell wall macromolecule metabolic process (GO:0044036)6.36872212
5sperm-egg recognition (GO:0035036)5.45491780
6binding of sperm to zona pellucida (GO:0007339)5.21218711
7ribosomal small subunit assembly (GO:0000028)5.19614309
8retinol metabolic process (GO:0042572)5.14611006
9cell-cell recognition (GO:0009988)5.14605364
10multicellular organism reproduction (GO:0032504)5.06145082
11sperm motility (GO:0030317)4.89498683
12interferon-gamma secretion (GO:0072643)4.81744406
13acrosome assembly (GO:0001675)4.69963492
14spermatid development (GO:0007286)4.66907142
15one-carbon compound transport (GO:0019755)4.58668983
16positive regulation of respiratory burst (GO:0060267)4.58188580
17regulation of transforming growth factor beta2 production (GO:0032909)4.55072358
18diterpenoid biosynthetic process (GO:0016102)4.54720205
19hemidesmosome assembly (GO:0031581)4.46654727
20melanin biosynthetic process (GO:0042438)4.42334513
21synaptonemal complex assembly (GO:0007130)4.38658951
22male meiosis (GO:0007140)4.37996635
23motile cilium assembly (GO:0044458)4.37599088
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.34746087
25piRNA metabolic process (GO:0034587)4.33986338
26acrosome reaction (GO:0007340)4.32821133
274-hydroxyproline metabolic process (GO:0019471)4.31834381
28reproduction (GO:0000003)4.30117676
29maturation of SSU-rRNA (GO:0030490)4.29177071
30gland morphogenesis (GO:0022612)4.24559661
31antigen processing and presentation of endogenous antigen (GO:0019883)4.18332253
32synaptonemal complex organization (GO:0070193)4.17666837
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.14819366
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.05465922
35negative regulation of cell killing (GO:0031342)4.05465922
36retinoic acid metabolic process (GO:0042573)4.05261458
37cellular response to electrical stimulus (GO:0071257)3.90873667
38peptidyl-proline hydroxylation (GO:0019511)3.87684328
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.80464622
40melanin metabolic process (GO:0006582)3.77895355
41fat-soluble vitamin metabolic process (GO:0006775)3.76868402
42viral transcription (GO:0019083)3.75821053
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.71040072
44regulation of posttranscriptional gene silencing (GO:0060147)3.70970134
45regulation of gene silencing by miRNA (GO:0060964)3.70970134
46regulation of gene silencing by RNA (GO:0060966)3.70970134
47DNA deamination (GO:0045006)3.70535458
48leukocyte aggregation (GO:0070486)3.69044430
49regulation of B cell receptor signaling pathway (GO:0050855)3.65784951
50L-ascorbic acid metabolic process (GO:0019852)3.61403599
51somatic stem cell division (GO:0048103)3.60348575
52translational termination (GO:0006415)3.56972352
53regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.56689306
54secondary metabolite biosynthetic process (GO:0044550)3.47354979
55ribosomal small subunit biogenesis (GO:0042274)3.43541687
56positive regulation of gamma-delta T cell activation (GO:0046645)3.41111171
57cellular response to arsenic-containing substance (GO:0071243)3.37909599
58spermatogenesis (GO:0007283)3.36193838
59citrulline biosynthetic process (GO:0019240)3.35748132
60male gamete generation (GO:0048232)3.35086357
61protein complex localization (GO:0031503)3.34868984
62epithelial cilium movement (GO:0003351)3.34689779
63axonemal dynein complex assembly (GO:0070286)3.34198633
64primary alcohol metabolic process (GO:0034308)3.33635390
65regulation of regulatory T cell differentiation (GO:0045589)3.32502257
66chromosome condensation (GO:0030261)3.31626797
67camera-type eye morphogenesis (GO:0048593)3.31383639
68immunoglobulin mediated immune response (GO:0016064)3.31377933
69positive regulation of macrophage activation (GO:0043032)3.29722053
70positive regulation of antigen processing and presentation (GO:0002579)3.26836381
71single fertilization (GO:0007338)3.24401508
72translational elongation (GO:0006414)3.22696155
73terpenoid biosynthetic process (GO:0016114)3.21058080
74detection of bacterium (GO:0016045)3.19568554
75negative regulation of epidermal cell differentiation (GO:0045605)3.17482666
76negative thymic T cell selection (GO:0045060)3.17297486
77protein-chromophore linkage (GO:0018298)3.16790107
78negative regulation of epidermis development (GO:0045683)3.16757797
79negative T cell selection (GO:0043383)3.16265468
80gamete generation (GO:0007276)3.15999284
81response to type I interferon (GO:0034340)3.15110675
82regulation of T cell mediated cytotoxicity (GO:0001914)3.14801538
83regulation of antigen processing and presentation (GO:0002577)3.14773873
84positive regulation of T cell mediated cytotoxicity (GO:0001916)3.14173851
85fertilization (GO:0009566)3.10520971
86chromosome organization involved in meiosis (GO:0070192)3.10394317
87cellular response to type I interferon (GO:0071357)3.08562737
88type I interferon signaling pathway (GO:0060337)3.08562737
89regulation of cardioblast differentiation (GO:0051890)3.08212397
90positive thymic T cell selection (GO:0045059)3.05555380
91regulation of histone H3-K9 methylation (GO:0051570)3.04753793
92germ cell development (GO:0007281)3.04421003
93protein hydroxylation (GO:0018126)3.03728285
94embryonic digestive tract development (GO:0048566)3.03267019
95positive regulation of defense response to virus by host (GO:0002230)3.01661955
96L-fucose catabolic process (GO:0042355)2.99727129
97fucose catabolic process (GO:0019317)2.99727129
98L-fucose metabolic process (GO:0042354)2.99727129
99regulation of gamma-delta T cell activation (GO:0046643)2.98838776
100DNA packaging (GO:0006323)2.98748465
101SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.98100851
102positive regulation of granulocyte differentiation (GO:0030854)2.97956668
103RNA-dependent DNA replication (GO:0006278)2.97111087
104regulation of hair follicle development (GO:0051797)2.96684972
105negative regulation of T cell mediated immunity (GO:0002710)2.94531607
106protein maturation by protein folding (GO:0022417)2.94359355
107cilium or flagellum-dependent cell motility (GO:0001539)2.93702081
108telomere maintenance via telomerase (GO:0007004)2.93601487
109regulation of gamma-delta T cell differentiation (GO:0045586)2.92577652
110xenobiotic catabolic process (GO:0042178)2.92424762
111protein targeting to ER (GO:0045047)2.91432404
112cotranslational protein targeting to membrane (GO:0006613)2.91248292
113regulation of skeletal muscle contraction (GO:0014819)2.91026008
114neutrophil activation involved in immune response (GO:0002283)2.88589987
115nucleoside diphosphate catabolic process (GO:0009134)2.88483347
116cellular process involved in reproduction in multicellular organism (GO:0022412)2.87035575
117detection of other organism (GO:0098543)2.85924338
118DNA damage induced protein phosphorylation (GO:0006975)2.85730752
119cellular protein complex disassembly (GO:0043624)2.85522905
120positive regulation of Cdc42 GTPase activity (GO:0043089)2.84542350
121autophagic vacuole fusion (GO:0000046)2.84047383
122polarized epithelial cell differentiation (GO:0030859)2.83866179
123bundle of His cell to Purkinje myocyte communication (GO:0086069)2.82755592
124response to interferon-beta (GO:0035456)2.82504504
125DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.82338560
126pathway-restricted SMAD protein phosphorylation (GO:0060389)2.82057733
127chaperone mediated protein folding requiring cofactor (GO:0051085)2.81497551
128cytidine metabolic process (GO:0046087)2.81451042
129cytidine catabolic process (GO:0006216)2.81451042
130cytidine deamination (GO:0009972)2.81451042
131positive regulation of T cell apoptotic process (GO:0070234)2.80800406
132calcium ion-dependent exocytosis (GO:0017156)2.80774539
133regulation of hippo signaling (GO:0035330)2.80030871
134regulation of dendritic cell antigen processing and presentation (GO:0002604)2.79694925
135negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.77949386
136positive regulation of hair follicle development (GO:0051798)2.77882316
137positive regulation of hair cycle (GO:0042635)2.77882316
138positive T cell selection (GO:0043368)2.77536049
139cytokine biosynthetic process (GO:0042089)2.77400051
140negative regulation of lymphocyte mediated immunity (GO:0002707)2.74306218
141thymic T cell selection (GO:0045061)2.74215623
142purinergic nucleotide receptor signaling pathway (GO:0035590)2.70485312
143organelle membrane fusion (GO:0090174)2.68140342
144T cell selection (GO:0045058)2.67932925
145adaptation of signaling pathway (GO:0023058)2.67777495
146negative regulation of innate immune response (GO:0045824)2.64656613
147regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.64525311
148cytochrome complex assembly (GO:0017004)2.61779819
149neutrophil activation (GO:0042119)2.56040097
150positive regulation of interleukin-1 beta secretion (GO:0050718)2.54750532
151positive regulation of interleukin-1 beta production (GO:0032731)2.54183396
152negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.53620192
153regulation of alpha-beta T cell proliferation (GO:0046640)2.51672352
154regulation of T cell receptor signaling pathway (GO:0050856)2.49750683
155regulation of B cell apoptotic process (GO:0002902)2.49591965
156negative regulation of interleukin-1 beta production (GO:0032691)2.49416217
157pyrimidine ribonucleoside catabolic process (GO:0046133)2.49329407
158negative regulation of phagocytosis (GO:0050765)2.49308064
159negative regulation of bone resorption (GO:0045779)2.48829654
160interferon-gamma-mediated signaling pathway (GO:0060333)2.48534466
161negative regulation of interleukin-12 production (GO:0032695)2.48378193
162cellular response to interleukin-15 (GO:0071350)2.47975297
163negative regulation of leukocyte mediated immunity (GO:0002704)2.47113372
164mast cell activation (GO:0045576)2.45441418
165defense response to protozoan (GO:0042832)2.45281812
166regulation of T cell tolerance induction (GO:0002664)2.44529619
167regulation of germinal center formation (GO:0002634)2.44150221
168regulation of leukocyte mediated cytotoxicity (GO:0001910)2.42884100
169regulation of T cell mediated immunity (GO:0002709)2.42560291
170response to interleukin-15 (GO:0070672)2.42425965
171regulation of interleukin-1 beta secretion (GO:0050706)2.41823150
172negative regulation of interleukin-1 production (GO:0032692)2.40589905
173desmosome organization (GO:0002934)2.40330997
174negative regulation of interleukin-6 production (GO:0032715)2.39659208
175modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.39613106
176positive regulation by organism of defense response of other organism involved in symbiotic interact2.39613106
177modulation by symbiont of host immune response (GO:0052553)2.39613106
178positive regulation by symbiont of host defense response (GO:0052509)2.39613106
179modulation by symbiont of host defense response (GO:0052031)2.39613106
180modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.39613106
181negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.39421131
182negative regulation of T-helper cell differentiation (GO:0045623)2.39421131
183respiratory chain complex IV assembly (GO:0008535)2.39150665
184regulation of B cell differentiation (GO:0045577)2.38908628
185regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.38755038
186regulation of natural killer cell mediated immunity (GO:0002715)2.38755038
187cellular response to exogenous dsRNA (GO:0071360)2.37606458
188negative regulation of glycoprotein biosynthetic process (GO:0010561)2.36787875
189positive regulation of histone deacetylation (GO:0031065)2.36624650
190positive regulation of interleukin-1 secretion (GO:0050716)2.36470994
191positive regulation of protein deacetylation (GO:0090312)2.35571004
192regulation of defense response to virus by host (GO:0050691)2.33320035
193positive regulation of B cell differentiation (GO:0045579)2.31354274
194tolerance induction (GO:0002507)2.30501965
195cytokine metabolic process (GO:0042107)2.29864028
196regulation of memory T cell differentiation (GO:0043380)2.29292420
197leukocyte degranulation (GO:0043299)2.29057263
198regulation of interleukin-1 beta production (GO:0032651)2.28716137
199vitamin A metabolic process (GO:0006776)13.3660242
200fusion of sperm to egg plasma membrane (GO:0007342)10.6843850

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.17663482
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.87331028
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.87070469
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.72973888
5TRIM28_21343339_ChIP-Seq_HEK293_Human4.11260755
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.77902048
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.47275339
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.34980828
9RARG_19884340_ChIP-ChIP_MEFs_Mouse3.16355683
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.14957111
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.14339200
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.10419726
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.77267265
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.63581259
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.61134267
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.54587469
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.35104026
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.22998814
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.16218890
20SCL_19346495_ChIP-Seq_HPC-7_Human2.13487618
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.09954621
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.04429419
23HIF1A_21447827_ChIP-Seq_MCF-7_Human2.02941134
24RUNX_20019798_ChIP-Seq_JUKART_Human1.98986808
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95727730
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.93847468
27AR_21909140_ChIP-Seq_LNCAP_Human1.90892421
28TCF3_18692474_ChIP-Seq_MEFs_Mouse1.88762371
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83899669
30MYB_26560356_Chip-Seq_TH2_Human1.81182356
31BCL6_27268052_Chip-Seq_Bcells_Human1.78671158
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76919393
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74743958
34SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.71435196
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71053385
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.70032135
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.69990410
38GATA3_26560356_Chip-Seq_TH2_Human1.63544583
39GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.61955101
40NANOG_18692474_ChIP-Seq_MEFs_Mouse1.61840411
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.60518195
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.59850190
43SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.58697323
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.58697323
45VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.57492459
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.54659945
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52827008
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52827008
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52827008
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51433037
51GATA3_27048872_Chip-Seq_THYMUS_Human1.49677301
52ZNF274_21170338_ChIP-Seq_K562_Hela1.49198612
53SPI1_23547873_ChIP-Seq_NB4_Human1.48392445
54SPI1_23127762_ChIP-Seq_K562_Human1.46896550
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44603449
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43812060
57MYB_26560356_Chip-Seq_TH1_Human1.42308173
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.41988950
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41985446
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40281322
61E2F1_20622854_ChIP-Seq_HELA_Human1.40014982
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.39331157
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38961352
64SOX2_18692474_ChIP-Seq_MEFs_Mouse1.37582020
65CJUN_26792858_Chip-Seq_BT549_Human1.37497286
66TCF4_18268006_ChIP-ChIP_LS174T_Human1.37331025
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36150288
68MAF_26560356_Chip-Seq_TH1_Human1.36074762
69P300_27268052_Chip-Seq_Bcells_Human1.35802552
70RUNX1_27514584_Chip-Seq_MCF-7_Human1.35596697
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35483376
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35138272
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34655820
74* MAF_26560356_Chip-Seq_TH2_Human1.34511136
75NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.34054588
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33726730
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33392967
78VDR_24763502_ChIP-Seq_THP-1_Human1.32435894
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.31774882
80SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.30945403
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30537097
82SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29163714
83TAF2_19829295_ChIP-Seq_ESCs_Human1.28873467
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28765500
85PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28014640
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27524128
87UTX_26944678_Chip-Seq_JUKART_Human1.26057296
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26011558
89FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25518106
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.25113973
91STAT1_20625510_ChIP-Seq_HELA_Human1.24866617
92* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.24653933
93ERA_21632823_ChIP-Seq_H3396_Human1.21025904
94KLF5_25053715_ChIP-Seq_YYC3_Human1.19300418
95JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18581180
96PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.17661154
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16836802
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16562124
99P68_20966046_ChIP-Seq_HELA_Human1.16399675
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16123543
101SOX2_22085726_ChIP-Seq_NPCs_Mouse1.15982335
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15568002
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14207376
104TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14052039
105RUNX1_22412390_ChIP-Seq_EML_Mouse1.13900193
106MYC_18555785_ChIP-Seq_MESCs_Mouse1.13729896
107YY1_22570637_ChIP-Seq_MALME-3M_Human1.13601866
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13451049
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13373118
110GATA6_25053715_ChIP-Seq_YYC3_Human1.13231823
111VDR_21846776_ChIP-Seq_THP-1_Human1.13226287
112POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12590982
113NANOG_18692474_ChIP-Seq_MESCs_Mouse1.12513286
114STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11271674
115GATA3_21878914_ChIP-Seq_MCF-7_Human1.11182572
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10580847
117RAC3_21632823_ChIP-Seq_H3396_Human1.10205714
118FOXA1_25329375_ChIP-Seq_VCAP_Human1.09697090
119FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09697090
120TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.09578247
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09527698
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09515281
123SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08743251
124ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08625952
125EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08223043
126CTCF_20526341_ChIP-Seq_ESCs_Human1.08016759
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07010061
128PHF8_20622854_ChIP-Seq_HELA_Human1.06473554
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06123742
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05034368
131ELF1_20517297_ChIP-Seq_JURKAT_Human1.04955063
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04653796
133NOTCH1_21737748_ChIP-Seq_TLL_Human1.04603201
134TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04406581
135VDR_22108803_ChIP-Seq_LS180_Human1.04106221
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03261729
137FOXH1_21741376_ChIP-Seq_ESCs_Human1.03216080
138CSB_26484114_Chip-Seq_FIBROBLAST_Human1.02815388
139GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02250974
140JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01413849
141SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00061712
142CTCF_26484167_Chip-Seq_Bcells_Mouse0.99795359
143BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99603753
144MYC_19829295_ChIP-Seq_ESCs_Human0.99532621
145NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99344997
146CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99122202
147SOX2_20726797_ChIP-Seq_SW620_Human0.98864762
148TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98276456
149SRF_21415370_ChIP-Seq_HL-1_Mouse0.97324266
150KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97067982
151FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96803144
152P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.96689608
153SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96594643
154ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96245314
155STAT1_17558387_ChIP-Seq_HELA_Human0.95919701
156TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95392735
157FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94894580
158GATA1_19941826_ChIP-Seq_K562_Human0.93589325
159OCT4_20526341_ChIP-Seq_ESCs_Human0.93540289
160* TP63_22573176_ChIP-Seq_HFKS_Human0.93471316
161SMRT_27268052_Chip-Seq_Bcells_Human0.92907692
162GATA1_22025678_ChIP-Seq_K562_Human0.92436970
163AR_20517297_ChIP-Seq_VCAP_Human0.92327856
164CEBPB_22108803_ChIP-Seq_LS180_Human0.92256577
165SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.91830230
166GATA2_21666600_ChIP-Seq_HMVEC_Human0.91530659
167EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91504509
168VDR_24787735_ChIP-Seq_THP-1_Human0.91470734
169RACK7_27058665_Chip-Seq_MCF-7_Human0.90445544
170P53_21459846_ChIP-Seq_SAOS-2_Human0.90094907
171BCOR_27268052_Chip-Seq_Bcells_Human0.90091904
172SA1_27219007_Chip-Seq_ERYTHROID_Human0.89733963
173ATF3_27146783_Chip-Seq_COLON_Human0.89680216
174* ER_23166858_ChIP-Seq_MCF-7_Human0.89167526
175RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88771716
176PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88347880
177* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88338929
178NANOG_16518401_ChIP-PET_MESCs_Mouse0.88109248
179NANOG_20526341_ChIP-Seq_ESCs_Human0.87495343
180GATA3_24758297_ChIP-Seq_MCF-7_Human0.87252589
181ERG_20517297_ChIP-Seq_VCAP_Human0.87116402
182GATA4_25053715_ChIP-Seq_YYC3_Human0.86426577
183TBX20_22328084_ChIP-Seq_HEART_Mouse0.86338046
184TBX20_22080862_ChIP-Seq_HEART_Mouse0.86338046
185UBF1/2_26484160_Chip-Seq_HMECs_Human0.85766314
186SOX2_18692474_ChIP-Seq_MESCs_Mouse0.85218977
187KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84509262
188CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83128004
189CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83093837
190MYC_27129775_Chip-Seq_CORNEA_Mouse0.81371980
191CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80853136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation8.14339210
2MP0005410_abnormal_fertilization4.37801196
3MP0005671_abnormal_response_to3.07504728
4MP0001835_abnormal_antigen_presentation2.84137382
5MP0010234_abnormal_vibrissa_follicle2.81410600
6MP0003136_yellow_coat_color2.71575657
7MP0005076_abnormal_cell_differentiation2.64599849
8MP0001800_abnormal_humoral_immune2.50398209
9MP0005408_hypopigmentation2.49336299
10MP0003763_abnormal_thymus_physiology2.49156711
11MP0008004_abnormal_stomach_pH2.46416429
12MP0006054_spinal_hemorrhage2.45674110
13MP0002234_abnormal_pharynx_morphology2.42772843
14MP0003724_increased_susceptibility_to2.41757211
15MP0000685_abnormal_immune_system2.39326023
16MP0002148_abnormal_hypersensitivity_rea2.34808164
17MP0003436_decreased_susceptibility_to2.33878325
18MP0004019_abnormal_vitamin_homeostasis2.33081243
19MP0001929_abnormal_gametogenesis2.33068683
20MP0005000_abnormal_immune_tolerance2.31521350
21MP0003941_abnormal_skin_development2.29884808
22MP0000537_abnormal_urethra_morphology2.28658714
23MP0001849_ear_inflammation2.22178566
24MP0001790_abnormal_immune_system2.21588270
25MP0005387_immune_system_phenotype2.21588270
26MP0009785_altered_susceptibility_to2.21073393
27MP0004381_abnormal_hair_follicle2.20476013
28MP0002254_reproductive_system_inflammat2.19507604
29MP0003172_abnormal_lysosome_physiology2.16307924
30MP0005025_abnormal_response_to2.16131604
31MP0000372_irregular_coat_pigmentation2.15281137
32MP0000566_synostosis2.13210994
33MP0002723_abnormal_immune_serum2.13182175
34MP0005075_abnormal_melanosome_morpholog2.08192982
35MP0005257_abnormal_intraocular_pressure2.06480514
36MP0002420_abnormal_adaptive_immunity2.00714686
37MP0001819_abnormal_immune_cell1.99017130
38MP0002452_abnormal_antigen_presenting1.97879854
39MP0002210_abnormal_sex_determination1.90859757
40MP0002419_abnormal_innate_immunity1.85876471
41MP0002837_dystrophic_cardiac_calcinosis1.85394141
42MP0000467_abnormal_esophagus_morphology1.83984134
43MP0003698_abnormal_male_reproductive1.81865848
44MP0004043_abnormal_pH_regulation1.80711728
45MP0003195_calcinosis1.79891668
46MP0010030_abnormal_orbit_morphology1.76185835
47MP0002653_abnormal_ependyma_morphology1.71684486
48MP0008875_abnormal_xenobiotic_pharmacok1.68600976
49MP0001873_stomach_inflammation1.68288239
50MP0001986_abnormal_taste_sensitivity1.66955926
51MP0004272_abnormal_basement_membrane1.64537643
52MP0008438_abnormal_cutaneous_collagen1.64127568
53MP0002876_abnormal_thyroid_physiology1.61052043
54MP0002166_altered_tumor_susceptibility1.59807365
55MP0001324_abnormal_eye_pigmentation1.57603789
56MP0001919_abnormal_reproductive_system1.57296839
57MP0001145_abnormal_male_reproductive1.52038376
58MP0008872_abnormal_physiological_respon1.50517245
59MP0002877_abnormal_melanocyte_morpholog1.49675707
60MP0003566_abnormal_cell_adhesion1.49408568
61MP0001845_abnormal_inflammatory_respons1.49226222
62MP0003315_abnormal_perineum_morphology1.49126930
63MP0000653_abnormal_sex_gland1.48606628
64MP0005389_reproductive_system_phenotype1.48347465
65MP0003806_abnormal_nucleotide_metabolis1.47971824
66MP0005275_abnormal_skin_tensile1.47496661
67MP0000716_abnormal_immune_system1.46376298
68MP0009333_abnormal_splenocyte_physiolog1.46213119
69MP0010155_abnormal_intestine_physiology1.45053060
70MP0000015_abnormal_ear_pigmentation1.44827823
71MP0006082_CNS_inflammation1.44352511
72MP0003787_abnormal_imprinting1.43334793
73MP0002405_respiratory_system_inflammati1.43260285
74MP0003786_premature_aging1.42089311
75MP0005464_abnormal_platelet_physiology1.41934507
76MP0005248_abnormal_Harderian_gland1.41851249
77MP0004947_skin_inflammation1.41179133
78MP0002138_abnormal_hepatobiliary_system1.40451469
79MP0002398_abnormal_bone_marrow1.36942366
80MP0003866_abnormal_defecation1.35930533
81MP0003718_maternal_effect1.35421265
82MP0000383_abnormal_hair_follicle1.34670383
83MP0002095_abnormal_skin_pigmentation1.34329385
84MP0000427_abnormal_hair_cycle1.32198188
85MP0001533_abnormal_skeleton_physiology1.32130873
86MP0002796_impaired_skin_barrier1.31808000
87MP0005253_abnormal_eye_physiology1.28214404
88MP0010094_abnormal_chromosome_stability1.27415099
89MP0000689_abnormal_spleen_morphology1.27147011
90MP0005174_abnormal_tail_pigmentation1.25923436
91MP0000465_gastrointestinal_hemorrhage1.24958942
92MP0008469_abnormal_protein_level1.24906483
93MP0003123_paternal_imprinting1.24152625
94MP0003303_peritoneal_inflammation1.23843649
95MP0002693_abnormal_pancreas_physiology1.21896262
96MP0003111_abnormal_nucleus_morphology1.21869551
97MP0002396_abnormal_hematopoietic_system1.21765741
98MP0010352_gastrointestinal_tract_polyps1.17976418
99MP0001501_abnormal_sleep_pattern1.17813955
100MP0009278_abnormal_bone_marrow1.17380553
101MP0009764_decreased_sensitivity_to1.15609838
102MP0005310_abnormal_salivary_gland1.15481369
103MP0002161_abnormal_fertility/fecundity1.13633798
104MP0000013_abnormal_adipose_tissue1.13171271
105MP0002090_abnormal_vision1.12910489
106MP0002006_tumorigenesis1.12385186
107MP0004885_abnormal_endolymph1.12243090
108MP0001545_abnormal_hematopoietic_system1.12203248
109MP0005397_hematopoietic_system_phenotyp1.12203248
110MP0001765_abnormal_ion_homeostasis1.07648411
111MP0000579_abnormal_nail_morphology1.07007049
112MP0002722_abnormal_immune_system1.06710699
113MP0002429_abnormal_blood_cell1.06224303
114MP0004264_abnormal_extraembryonic_tissu1.04916581
115MP0005379_endocrine/exocrine_gland_phen1.04878283
116MP0005503_abnormal_tendon_morphology1.04586738
117MP0002163_abnormal_gland_morphology1.04559843
118MP0002092_abnormal_eye_morphology1.03386505
119MP0001764_abnormal_homeostasis1.03371326
120MP0005058_abnormal_lysosome_morphology1.02739373
121MP0002060_abnormal_skin_morphology1.01888890
122MP0003705_abnormal_hypodermis_morpholog1.00433233
123MP0002277_abnormal_respiratory_mucosa0.99380959
124MP0009643_abnormal_urine_homeostasis0.99185772
125MP0002089_abnormal_postnatal_growth/wei0.99010506
126MP0002160_abnormal_reproductive_system0.98731524
127MP0003115_abnormal_respiratory_system0.98696541
128MP0005646_abnormal_pituitary_gland0.98403896
129MP0005377_hearing/vestibular/ear_phenot0.98053737
130MP0003878_abnormal_ear_physiology0.98053737
131MP0005083_abnormal_biliary_tract0.96581508
132MP0009250_abnormal_appendicular_skeleto0.96062273
133MP0005391_vision/eye_phenotype0.95541344
134MP0005551_abnormal_eye_electrophysiolog0.95148918
135MP0000049_abnormal_middle_ear0.94923386
136MP0003828_pulmonary_edema0.94779193
137MP0003693_abnormal_embryo_hatching0.94413099
138MP0008007_abnormal_cellular_replicative0.94302546
139MP0003329_amyloid_beta_deposits0.94226548
140MP0000762_abnormal_tongue_morphology0.93777461
141MP0009840_abnormal_foam_cell0.92602402
142MP0003119_abnormal_digestive_system0.92545132
143MP0004957_abnormal_blastocyst_morpholog0.91769904
144MP0001346_abnormal_lacrimal_gland0.91615477
145MP0003045_fibrosis0.89044074
146MP0003075_altered_response_to0.89022383
147MP0005197_abnormal_uvea_morphology0.88725307
148MP0002933_joint_inflammation0.87600112
149MP0005645_abnormal_hypothalamus_physiol0.86567278
150MP0000703_abnormal_thymus_morphology0.86061430
151MP0002249_abnormal_larynx_morphology0.85783510
152MP0003638_abnormal_response/metabolism_0.85753381
153MP0003937_abnormal_limbs/digits/tail_de0.85489043
154MP0006036_abnormal_mitochondrial_physio0.85314361
155MP0003942_abnormal_urinary_system0.84832539
156MP0005023_abnormal_wound_healing0.83811197
157MP0010678_abnormal_skin_adnexa0.83465600
158MP0001119_abnormal_female_reproductive0.82280274
159MP0002233_abnormal_nose_morphology0.81803907
160MP0003385_abnormal_body_wall0.81136382
161MP0005171_absent_coat_pigmentation0.80592682
162MP0010329_abnormal_lipoprotein_level0.80137514
163MP0001216_abnormal_epidermal_layer0.78537672
164MP0005084_abnormal_gallbladder_morpholo0.78075973
165MP0002132_abnormal_respiratory_system0.77315301
166MP0002282_abnormal_trachea_morphology0.75959530
167MP0000003_abnormal_adipose_tissue0.75590570
168MP0000613_abnormal_salivary_gland0.75535977
169MP0001915_intracranial_hemorrhage0.75391685
170MP0000681_abnormal_thyroid_gland0.75060898
171MP0000371_diluted_coat_color0.74938356
172MP0008877_abnormal_DNA_methylation0.73049647
173MP0005220_abnormal_exocrine_pancreas0.72842723
174MP0003699_abnormal_female_reproductive0.72619201
175MP0003936_abnormal_reproductive_system0.71712592
176MP0000432_abnormal_head_morphology0.71630795
177MP0005508_abnormal_skeleton_morphology0.71004773
178MP0010368_abnormal_lymphatic_system0.70944185
179MP0009053_abnormal_anal_canal0.70219732
180MP0005501_abnormal_skin_physiology0.69855788
181MP0000678_abnormal_parathyroid_gland0.69641371
182MP0009379_abnormal_foot_pigmentation0.69061709
183MP0005647_abnormal_sex_gland0.68407876
184MP0008789_abnormal_olfactory_epithelium0.66284573
185MP0005193_abnormal_anterior_eye0.65950870
186MP0001664_abnormal_digestion0.65241743
187MP0002177_abnormal_outer_ear0.64595717
188MP0005623_abnormal_meninges_morphology0.63936823
189MP0000490_abnormal_crypts_of0.63180756
190MP0003453_abnormal_keratinocyte_physiol0.59122171

Predicted human phenotypes

RankGene SetZ-score
1Decreased electroretinogram (ERG) amplitude (HP:0000654)7.34852634
2Degeneration of anterior horn cells (HP:0002398)4.85614289
3Abnormality of the anterior horn cell (HP:0006802)4.85614289
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.67078914
5Nonprogressive disorder (HP:0003680)4.63008068
6Attenuation of retinal blood vessels (HP:0007843)4.46736077
7Decreased central vision (HP:0007663)4.30412633
8Stenosis of the external auditory canal (HP:0000402)4.20846934
9Stomatitis (HP:0010280)4.18447331
10Hypopigmentation of the fundus (HP:0007894)4.13824418
11Abnormality of the fovea (HP:0000493)4.08491345
12Spinal muscular atrophy (HP:0007269)4.05268310
13Arterial tortuosity (HP:0005116)4.03536437
14Elevated erythrocyte sedimentation rate (HP:0003565)3.88104566
15Absent/shortened dynein arms (HP:0200106)3.79652244
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.79652244
17Bicuspid aortic valve (HP:0001647)3.62453372
18Increased IgE level (HP:0003212)3.58665568
19Vascular tortuosity (HP:0004948)3.58354236
20Chronic bronchitis (HP:0004469)3.56420927
21Aortic dissection (HP:0002647)3.51722583
22Infertility (HP:0000789)3.50641134
23Weak cry (HP:0001612)3.44505030
24Male infertility (HP:0003251)3.37509929
25Pustule (HP:0200039)3.30694669
26Short nail (HP:0001799)3.28853958
27Esophageal atresia (HP:0002032)3.28426156
28Panhypogammaglobulinemia (HP:0003139)3.20516877
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.16839018
30Spondylolisthesis (HP:0003302)3.15389057
31Atrophic scars (HP:0001075)3.15142186
32Myositis (HP:0100614)3.14197268
33Hypoplasia of the fovea (HP:0007750)3.14087028
34Aplasia/Hypoplasia of the fovea (HP:0008060)3.14087028
35Nasal polyposis (HP:0100582)3.12411688
36Diaphragmatic weakness (HP:0009113)3.11351210
37Tubulointerstitial nephritis (HP:0001970)3.06537280
38Vascular calcification (HP:0004934)3.02711348
39Abnormality of dentin (HP:0010299)3.00168078
40Milia (HP:0001056)2.99032500
41Pili torti (HP:0003777)2.94501123
42Stridor (HP:0010307)2.87716610
43Cardiovascular calcification (HP:0011915)2.87691460
44Palmoplantar hyperkeratosis (HP:0000972)2.87639597
4511 pairs of ribs (HP:0000878)2.83652535
46Aplasia/Hypoplasia of the macula (HP:0008059)2.82444811
47Keratoconus (HP:0000563)2.82032212
48Increased corneal curvature (HP:0100692)2.82032212
49Abnormal respiratory motile cilium physiology (HP:0012261)2.80438247
50Right ventricular cardiomyopathy (HP:0011663)2.79002906
51Alopecia of scalp (HP:0002293)2.75834379
52Oral leukoplakia (HP:0002745)2.73276140
53Recurrent fungal infections (HP:0002841)2.71920332
54Type II lissencephaly (HP:0007260)2.71681322
55Missing ribs (HP:0000921)2.69648002
56Recurrent bacterial skin infections (HP:0005406)2.68848131
57Plantar hyperkeratosis (HP:0007556)2.68019561
58Onycholysis (HP:0001806)2.67034182
59Fragile nails (HP:0001808)2.60433911
60Palmar hyperkeratosis (HP:0010765)2.59390406
61Abnormal rod and cone electroretinograms (HP:0008323)2.59009797
62Aplasia/Hypoplasia affecting the retina (HP:0008061)2.58415728
63Choroideremia (HP:0001139)2.57889192
64Abnormality of the nasal mucosa (HP:0000433)2.53961893
65Keratoconjunctivitis (HP:0001096)2.52209578
66Meningitis (HP:0001287)2.51206167
67Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.49672528
68Erythroderma (HP:0001019)2.47318415
69Chronic obstructive pulmonary disease (HP:0006510)2.46561742
70Obstructive lung disease (HP:0006536)2.46561742
71Abnormality of macrophages (HP:0004311)2.45362468
72Keratoconjunctivitis sicca (HP:0001097)2.43750619
73Orchitis (HP:0100796)2.42679194
74Abnormality of nail color (HP:0100643)2.40892232
75Keratitis (HP:0000491)2.38988147
76Congenital stationary night blindness (HP:0007642)2.38532054
77Eczematoid dermatitis (HP:0000976)2.38105067
78Absent rod-and cone-mediated responses on ERG (HP:0007688)2.37951132
79Agammaglobulinemia (HP:0004432)2.37802485
80Rectal prolapse (HP:0002035)2.37551801
81Abnormal hair laboratory examination (HP:0003328)2.37282978
82Abnormality of glycosphingolipid metabolism (HP:0004343)2.36341603
83Abnormality of glycolipid metabolism (HP:0010969)2.36341603
84Abnormality of liposaccharide metabolism (HP:0010968)2.36341603
85Abnormal respiratory epithelium morphology (HP:0012253)2.35083439
86Abnormal respiratory motile cilium morphology (HP:0005938)2.35083439
87Colon cancer (HP:0003003)2.35005873
88Pulmonary infiltrates (HP:0002113)2.34769874
89IgG deficiency (HP:0004315)2.33644827
90Severe visual impairment (HP:0001141)2.31904342
91Biliary tract neoplasm (HP:0100574)2.31273977
92Optic neuritis (HP:0100653)2.30658758
93Retrobulbar optic neuritis (HP:0100654)2.30658758
94Recurrent abscess formation (HP:0002722)2.29070480
95Spastic diplegia (HP:0001264)2.29006818
96Gastrointestinal infarctions (HP:0005244)2.28620725
97Abnormality of T cell physiology (HP:0011840)2.27528962
98Recurrent cutaneous fungal infections (HP:0011370)2.23757595
99Chronic mucocutaneous candidiasis (HP:0002728)2.23757595
100Recurrent skin infections (HP:0001581)2.22619472
101Cerebellar dysplasia (HP:0007033)2.20654029
102Hypoproteinemia (HP:0003075)2.20500611
103Furrowed tongue (HP:0000221)2.19986312
104Severe combined immunodeficiency (HP:0004430)2.19985938
105Abnormality of cells of the erythroid lineage (HP:0012130)2.19788936
106Mediastinal lymphadenopathy (HP:0100721)2.19341128
107Abnormality of mucopolysaccharide metabolism (HP:0011020)2.17000765
108Abnormality of polysaccharide metabolism (HP:0011012)2.17000765
109Abnormality of glycosaminoglycan metabolism (HP:0004371)2.17000765
110Protrusio acetabuli (HP:0003179)2.16534412
111Abnormality of T cells (HP:0002843)2.16045739
112Parakeratosis (HP:0001036)2.15195450
113Dry hair (HP:0011359)2.14656235
114Albinism (HP:0001022)2.13873576
115Rhinitis (HP:0012384)2.12224324
116Inflammation of the large intestine (HP:0002037)2.11057122
117Encephalitis (HP:0002383)2.10506442
118Amelogenesis imperfecta (HP:0000705)2.09303329
119Selective tooth agenesis (HP:0001592)2.07431438
120Hypoplasia of dental enamel (HP:0006297)2.06442836
121Vasculitis (HP:0002633)2.05434254
122Aortic aneurysm (HP:0004942)2.04354717
123Abnormality of the prostate (HP:0008775)2.04237854
124Petechiae (HP:0000967)2.04225174
125Hemoptysis (HP:0002105)2.03886307
126Gastrointestinal inflammation (HP:0004386)2.01788248
127Woolly hair (HP:0002224)2.01775053
128Pancreatic cysts (HP:0001737)1.98983434
129Retinal atrophy (HP:0001105)1.98005030
130Absent thumb (HP:0009777)1.97421737
131Small intestinal stenosis (HP:0012848)1.97023639
132Duodenal stenosis (HP:0100867)1.97023639
133Prolonged bleeding time (HP:0003010)1.96017573
134Abnormality of the renal cortex (HP:0011035)1.95980943
135Atrophy/Degeneration involving motor neurons (HP:0007373)1.94170479
136Increased CSF protein (HP:0002922)1.92600923
137Thyroiditis (HP:0100646)1.92076686
138Polydipsia (HP:0001959)1.92007161
139Abnormal drinking behavior (HP:0030082)1.92007161
140Episodic fever (HP:0001954)1.90889667
141Chest pain (HP:0100749)1.90673032
142Urinary glycosaminoglycan excretion (HP:0003541)1.89894071
143Mucopolysacchariduria (HP:0008155)1.89894071
144Granulocytopenia (HP:0001913)1.89810710
145Gangrene (HP:0100758)1.89786212
146Increased neuronal autofluorescent lipopigment (HP:0002074)1.89126182
147Oligodactyly (HP:0012165)1.88601625
148Autoimmune hemolytic anemia (HP:0001890)1.88494474
149Cutaneous melanoma (HP:0012056)1.87945785
150Tetany (HP:0001281)1.86033492
151Dysostosis multiplex (HP:0000943)1.85474629
152Hypoplastic labia majora (HP:0000059)1.85411147
153Tubulointerstitial abnormality (HP:0001969)1.84777631
154Synostosis involving bones of the hand (HP:0004278)1.84596347
155Ankle contracture (HP:0006466)1.84557053
156Tubulointerstitial fibrosis (HP:0005576)1.82501520
157Hypergammaglobulinemia (HP:0010702)1.82293885
158Fused cervical vertebrae (HP:0002949)1.82232922
159Hematochezia (HP:0002573)1.81574251
160Ketosis (HP:0001946)1.80700100
161Cholecystitis (HP:0001082)1.80280279
162Abnormal gallbladder physiology (HP:0012438)1.80280279
163Urticaria (HP:0001025)1.79996001
164Hepatocellular necrosis (HP:0001404)1.79955309
165Dicarboxylic aciduria (HP:0003215)1.79875594
166Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79875594
167Abnormality of DNA repair (HP:0003254)1.79728116
168Abnormality of transition element cation homeostasis (HP:0011030)1.79707512
169Mitral valve prolapse (HP:0001634)1.79342144
170Abnormal number of erythroid precursors (HP:0012131)1.78203414
171Malnutrition (HP:0004395)1.76898746
172Hepatic necrosis (HP:0002605)1.76669182
173Abnormality of the 4th metacarpal (HP:0010012)1.75258465
174Ulnar bowing (HP:0003031)1.73616620
175Carpal synostosis (HP:0009702)1.73137703
176Testicular atrophy (HP:0000029)1.72184960
177Bowing of the arm (HP:0006488)1.71041349
178Bowed forearm bones (HP:0003956)1.71041349
179Trismus (HP:0000211)1.70882644
180Bronchitis (HP:0012387)1.70412817
181Increased cerebral lipofuscin (HP:0011813)1.69255218
182EMG: neuropathic changes (HP:0003445)1.68993445
183Unilateral renal agenesis (HP:0000122)1.68667330
184Fragile skin (HP:0001030)1.67492762
185Abnormality of the labia majora (HP:0012881)1.67308465
186Constricted visual fields (HP:0001133)1.66212740
187Reticulocytopenia (HP:0001896)1.66143988
188Choanal stenosis (HP:0000452)1.66039586
189Carpal bone hypoplasia (HP:0001498)1.65895393
190Abolished electroretinogram (ERG) (HP:0000550)1.65824344
191Abnormality of molar (HP:0011077)1.64446978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RPS6KB24.09306546
2EPHA24.05216337
3TAOK33.89938799
4FRK3.82643081
5TXK3.60692036
6MAP4K13.54029609
7EEF2K3.53825966
8PDK33.37499216
9PDK43.37499216
10TESK13.30785513
11MAP2K32.91687929
12PDK22.79022279
13MST42.56075066
14MAP3K92.37448238
15TRPM72.32915496
16GRK62.11426611
17STK102.03012992
18MST1R2.02208046
19LATS12.00900615
20IKBKB1.89173242
21ERBB31.88976534
22MAP4K21.88128334
23PRKD31.87522956
24ADRBK21.87312389
25PKN21.84130715
26ERN11.81366822
27GRK11.81131174
28IKBKE1.78323573
29PASK1.77397986
30MAPKAPK31.76299710
31KIT1.73171959
32DAPK21.71448290
33TBK11.71328205
34TAOK11.67997548
35LRRK21.64826143
36STK381.62161758
37IRAK41.59197557
38ITK1.55343689
39STK38L1.53939369
40FES1.51878558
41FER1.51596686
42MAP3K31.47796493
43SYK1.46856505
44MUSK1.45819677
45NEK21.45537712
46MAP3K41.44660170
47LATS21.42161947
48KSR21.41521897
49LMTK21.39769446
50JAK31.39635487
51ZAP701.39119086
52RIPK41.38961468
53TTK1.37977035
54BLK1.36946146
55PAK41.36286049
56BMPR1B1.34946004
57BCKDK1.33255067
58EPHB21.31311229
59MAP3K141.24886132
60CCNB11.23432017
61PINK11.22417758
62BTK1.20451900
63MET1.19437651
64CSF1R1.18686470
65NUAK11.16354808
66ARAF1.12577136
67EIF2AK11.12386255
68LCK1.11281278
69MAP2K21.08601296
70HCK1.07962089
71TGFBR21.05721294
72TTN1.05516347
73MOS1.05250453
74TGFBR11.02092934
75CSK1.01478959
76TLK11.00850367
77MAP3K81.00800272
78LYN1.00286867
79MAP2K60.98302548
80NTRK20.97832779
81TEC0.97062335
82MAP3K70.95756072
83DYRK30.95405385
84STK30.94040621
85MYLK0.92843021
86BRAF0.89891568
87PRKD20.89781365
88PHKG20.88373122
89PHKG10.88373122
90TYK20.87906747
91PRKCQ0.87317113
92IRAK10.86912857
93TYRO30.86482899
94SIK30.83838518
95MAP3K110.83768061
96PAK20.80416165
97VRK20.78735087
98FLT30.75687331
99CAMKK20.72487566
100HIPK20.71198855
101PLK40.70052673
102MAPK70.69216591
103CHUK0.69190447
104BUB10.68733126
105ACVR1B0.68408336
106PTK20.67451286
107MELK0.66664934
108MAP3K20.65274269
109SIK20.64848156
110INSRR0.63695059
111JAK10.63592424
112DAPK10.63012745
113MAPK130.61383044
114PAK10.60841873
115KDR0.60820595
116KSR10.60546205
117ERBB40.58937488
118AURKB0.58533450
119MAPK110.58080091
120OXSR10.57896944
121ADRBK10.57421657
122MAP3K60.55840152
123PTK60.54418357
124TRIB30.52587713
125PAK30.52470629
126ICK0.51901832
127PRKCH0.51670602
128STK40.51641492
129PIK3CG0.50141980
130MAP3K10.49916166
131GRK70.49356311
132FGFR30.49275452
133DYRK1B0.48058476
134WEE10.47927200
135ABL10.47309912
136STK110.47237095
137WNK40.47113415
138CDK70.46186645
139MAP2K40.44458063
140PIM10.44404699
141AURKA0.44075970
142DDR20.43817366
143CLK10.43424454
144PRKAA20.43036190
145RAF10.42082348
146IGF1R0.41412286
147PLK10.40999715
148MATK0.40641685
149MAPKAPK50.40636682
150PDGFRA0.40418503
151CDK80.40314786
152CAMKK10.40213858
153FGFR20.39782347
154ZAK0.38207958
155NME20.37076053
156NME10.37038583
157LIMK10.36938907
158BMPR20.35702661
159TNK20.35255668
160MAP3K130.34610836
161PRKCI0.34334037
162ABL20.34198841
163MAP2K10.32257681
164MARK30.31230997
165NTRK10.30151354
166ROCK20.28302105
167RPS6KA40.26916701
168PTK2B0.26891313
169CHEK20.24366907
170NEK10.23986143
171MAPK120.23723992
172CDK60.22373857
173STK390.22151051
174PDK10.18765536

Predicted pathways (KEGG)

RankGene SetZ-score
1Retinol metabolism_Homo sapiens_hsa008303.66170825
2Ribosome_Homo sapiens_hsa030103.43436124
3Primary immunodeficiency_Homo sapiens_hsa053403.25858454
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.22538294
5Graft-versus-host disease_Homo sapiens_hsa053323.03042313
6Allograft rejection_Homo sapiens_hsa053303.01863372
7Type I diabetes mellitus_Homo sapiens_hsa049402.99498754
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.97798142
9Autoimmune thyroid disease_Homo sapiens_hsa053202.96106179
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.88008989
11Glutathione metabolism_Homo sapiens_hsa004802.78717443
12TGF-beta signaling pathway_Homo sapiens_hsa043502.74856219
13Chemical carcinogenesis_Homo sapiens_hsa052042.60323424
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.53241035
15Asthma_Homo sapiens_hsa053102.29350722
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.18913130
17Mismatch repair_Homo sapiens_hsa034302.18266034
18Tyrosine metabolism_Homo sapiens_hsa003502.11609570
19Arachidonic acid metabolism_Homo sapiens_hsa005902.04757123
20Hippo signaling pathway_Homo sapiens_hsa043902.00187265
21Linoleic acid metabolism_Homo sapiens_hsa005911.98295150
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.95598315
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90992310
24Staphylococcus aureus infection_Homo sapiens_hsa051501.89736856
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88996494
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.88730122
27ECM-receptor interaction_Homo sapiens_hsa045121.81054359
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.75128355
29Oocyte meiosis_Homo sapiens_hsa041141.73259625
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69440264
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.67483241
32Hematopoietic cell lineage_Homo sapiens_hsa046401.65905342
33Antigen processing and presentation_Homo sapiens_hsa046121.65211639
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59946406
35Rheumatoid arthritis_Homo sapiens_hsa053231.54578849
36Phenylalanine metabolism_Homo sapiens_hsa003601.54234147
37Histidine metabolism_Homo sapiens_hsa003401.51419094
38Osteoclast differentiation_Homo sapiens_hsa043801.50619354
39Tight junction_Homo sapiens_hsa045301.50315631
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46483796
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46070735
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.44225783
43Cell cycle_Homo sapiens_hsa041101.40449162
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37425376
45Lysosome_Homo sapiens_hsa041421.37326800
46T cell receptor signaling pathway_Homo sapiens_hsa046601.36731673
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34066830
48Basal transcription factors_Homo sapiens_hsa030221.32041546
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.29308093
50Collecting duct acid secretion_Homo sapiens_hsa049661.29262299
51Regulation of autophagy_Homo sapiens_hsa041401.29253192
52p53 signaling pathway_Homo sapiens_hsa041151.22310958
53Glycerophospholipid metabolism_Homo sapiens_hsa005641.21481265
54Fatty acid degradation_Homo sapiens_hsa000711.20840963
55Adherens junction_Homo sapiens_hsa045201.19427452
56Pyruvate metabolism_Homo sapiens_hsa006201.19254668
57Tuberculosis_Homo sapiens_hsa051521.14593682
58Nitrogen metabolism_Homo sapiens_hsa009101.14509879
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13397434
60Small cell lung cancer_Homo sapiens_hsa052221.10432827
61B cell receptor signaling pathway_Homo sapiens_hsa046621.09851463
62Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08971246
63Measles_Homo sapiens_hsa051621.06644702
64Base excision repair_Homo sapiens_hsa034101.04511472
65Amoebiasis_Homo sapiens_hsa051461.04084649
66Other glycan degradation_Homo sapiens_hsa005111.03596319
67Butanoate metabolism_Homo sapiens_hsa006501.02508296
68DNA replication_Homo sapiens_hsa030301.01906322
69Herpes simplex infection_Homo sapiens_hsa051681.01884998
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96722948
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.96085250
72Vitamin digestion and absorption_Homo sapiens_hsa049770.95755590
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94707823
74Proteoglycans in cancer_Homo sapiens_hsa052050.94687241
75Peroxisome_Homo sapiens_hsa041460.93449273
76RNA transport_Homo sapiens_hsa030130.91960270
77ABC transporters_Homo sapiens_hsa020100.91862598
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89464778
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87851871
80Bile secretion_Homo sapiens_hsa049760.87843844
81Homologous recombination_Homo sapiens_hsa034400.87069527
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.86184162
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86060121
84Focal adhesion_Homo sapiens_hsa045100.84303116
85Toxoplasmosis_Homo sapiens_hsa051450.84253038
86Oxidative phosphorylation_Homo sapiens_hsa001900.83904393
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82530262
88Fatty acid biosynthesis_Homo sapiens_hsa000610.82058211
89Glucagon signaling pathway_Homo sapiens_hsa049220.80736356
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78484481
91TNF signaling pathway_Homo sapiens_hsa046680.78209198
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78079020
93Sphingolipid metabolism_Homo sapiens_hsa006000.77276373
94Influenza A_Homo sapiens_hsa051640.76942303
95Fructose and mannose metabolism_Homo sapiens_hsa000510.76516452
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76277612
97Viral myocarditis_Homo sapiens_hsa054160.74878493
98Purine metabolism_Homo sapiens_hsa002300.73922371
99Renal cell carcinoma_Homo sapiens_hsa052110.73626711
100Shigellosis_Homo sapiens_hsa051310.71646305
101Pentose phosphate pathway_Homo sapiens_hsa000300.71484854
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71301699
103Melanogenesis_Homo sapiens_hsa049160.71110818
104Tryptophan metabolism_Homo sapiens_hsa003800.70819821
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70117017
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69580670
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69012426
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67567813
109Bladder cancer_Homo sapiens_hsa052190.66946642
110Pyrimidine metabolism_Homo sapiens_hsa002400.66309019
111Hepatitis C_Homo sapiens_hsa051600.66097467
112Chemokine signaling pathway_Homo sapiens_hsa040620.64954152
113MicroRNAs in cancer_Homo sapiens_hsa052060.64599363
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64347415
115Biosynthesis of amino acids_Homo sapiens_hsa012300.62868314
116Thyroid hormone synthesis_Homo sapiens_hsa049180.62434198
117Dorso-ventral axis formation_Homo sapiens_hsa043200.62323844
118Nucleotide excision repair_Homo sapiens_hsa034200.62127209
119Fanconi anemia pathway_Homo sapiens_hsa034600.61646992
120Platelet activation_Homo sapiens_hsa046110.61203428
121Acute myeloid leukemia_Homo sapiens_hsa052210.60671325
122Ether lipid metabolism_Homo sapiens_hsa005650.59867811
123Malaria_Homo sapiens_hsa051440.59522857
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59510136
125Sulfur metabolism_Homo sapiens_hsa009200.59030016
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58071451
127Insulin secretion_Homo sapiens_hsa049110.57998188
128Propanoate metabolism_Homo sapiens_hsa006400.57817656
129African trypanosomiasis_Homo sapiens_hsa051430.57447826
130Sulfur relay system_Homo sapiens_hsa041220.56775334
131RNA degradation_Homo sapiens_hsa030180.56392672
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55552720
133GnRH signaling pathway_Homo sapiens_hsa049120.55236530
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53783642
135Phototransduction_Homo sapiens_hsa047440.53589067
136Ovarian steroidogenesis_Homo sapiens_hsa049130.52874773
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52659665
138VEGF signaling pathway_Homo sapiens_hsa043700.52187996
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.52132301
140Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51874555
141Chronic myeloid leukemia_Homo sapiens_hsa052200.51315875
142Thyroid cancer_Homo sapiens_hsa052160.51125835
143HIF-1 signaling pathway_Homo sapiens_hsa040660.50886066
144Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50669419
145Basal cell carcinoma_Homo sapiens_hsa052170.50363725
146Selenocompound metabolism_Homo sapiens_hsa004500.50141463
147HTLV-I infection_Homo sapiens_hsa051660.49862375
148Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49685451
149Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49629377
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49556373
151Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49307044
152Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48272913
153RNA polymerase_Homo sapiens_hsa030200.46843939
154Glycerolipid metabolism_Homo sapiens_hsa005610.46752718
155Leishmaniasis_Homo sapiens_hsa051400.46524827
156Insulin resistance_Homo sapiens_hsa049310.46159940
157Phagosome_Homo sapiens_hsa041450.45763927
158Dilated cardiomyopathy_Homo sapiens_hsa054140.45317502
159Pancreatic cancer_Homo sapiens_hsa052120.45102421
160Gastric acid secretion_Homo sapiens_hsa049710.44159678
161Salivary secretion_Homo sapiens_hsa049700.43969717
162Adipocytokine signaling pathway_Homo sapiens_hsa049200.43581898
163Legionellosis_Homo sapiens_hsa051340.43494599
164Leukocyte transendothelial migration_Homo sapiens_hsa046700.43036735
165Pathways in cancer_Homo sapiens_hsa052000.42524683
166Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41108294
167Renin secretion_Homo sapiens_hsa049240.40841627
168Rap1 signaling pathway_Homo sapiens_hsa040150.40384672
169Vibrio cholerae infection_Homo sapiens_hsa051100.38915395
170Primary bile acid biosynthesis_Homo sapiens_hsa001200.37847028
171FoxO signaling pathway_Homo sapiens_hsa040680.37837154
172Colorectal cancer_Homo sapiens_hsa052100.37648449
173Non-homologous end-joining_Homo sapiens_hsa034500.37064029
174PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36029818
175Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35862881
176Steroid hormone biosynthesis_Homo sapiens_hsa001400.35215362
177Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35154313
178Pancreatic secretion_Homo sapiens_hsa049720.35004910
179Pertussis_Homo sapiens_hsa051330.34277997
180Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33591549

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