UPK3BP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine-containing compound transmembrane transport (GO:0072531)4.97516594
2interferon-gamma production (GO:0032609)4.47301598
3regulation of interferon-beta biosynthetic process (GO:0045357)4.42751575
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.33177399
5negative regulation of cell killing (GO:0031342)4.33177399
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.31764842
7fucose catabolic process (GO:0019317)4.26132344
8L-fucose metabolic process (GO:0042354)4.26132344
9L-fucose catabolic process (GO:0042355)4.26132344
10mannose metabolic process (GO:0006013)4.23996100
11regulation of interferon-gamma-mediated signaling pathway (GO:0060334)4.03323243
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.94459020
13regulation of response to interferon-gamma (GO:0060330)3.85720524
14positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.82385400
15regulation of NFAT protein import into nucleus (GO:0051532)3.80770646
16fucose metabolic process (GO:0006004)3.70188067
17vitamin transmembrane transport (GO:0035461)3.63746478
18macrophage activation involved in immune response (GO:0002281)3.55553786
19antigen processing and presentation of endogenous antigen (GO:0019883)3.53416481
20response to muramyl dipeptide (GO:0032495)3.53252237
21tolerance induction (GO:0002507)3.47114169
22glucose 6-phosphate metabolic process (GO:0051156)3.46050601
23cellular response to exogenous dsRNA (GO:0071360)3.43123701
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.39945166
25positive regulation of gamma-delta T cell activation (GO:0046645)3.39556828
26response to type I interferon (GO:0034340)3.39024956
27cellular response to interleukin-15 (GO:0071350)3.38667721
28type I interferon signaling pathway (GO:0060337)3.36533915
29cellular response to type I interferon (GO:0071357)3.36533915
30embryonic process involved in female pregnancy (GO:0060136)3.32457367
31fucosylation (GO:0036065)3.29376442
32modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.25173439
33positive regulation by organism of defense response of other organism involved in symbiotic interact3.25173439
34modulation by symbiont of host immune response (GO:0052553)3.25173439
35positive regulation by symbiont of host defense response (GO:0052509)3.25173439
36modulation by symbiont of host defense response (GO:0052031)3.25173439
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.25173439
38positive regulation of Cdc42 GTPase activity (GO:0043089)3.24803190
39negative regulation of innate immune response (GO:0045824)3.21327834
40GDP-mannose metabolic process (GO:0019673)3.19804280
41positive regulation of granulocyte differentiation (GO:0030854)3.19443080
42response to peptidoglycan (GO:0032494)3.11419449
43regulation of defense response to virus by host (GO:0050691)3.10600128
44intracellular estrogen receptor signaling pathway (GO:0030520)3.04215564
45response to laminar fluid shear stress (GO:0034616)2.98451337
46response to interleukin-15 (GO:0070672)2.98235320
47NIK/NF-kappaB signaling (GO:0038061)2.98052502
48Arp2/3 complex-mediated actin nucleation (GO:0034314)2.95544251
49regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.94724014
50positive regulation of interferon-beta production (GO:0032728)2.88984852
51chaperone mediated protein folding requiring cofactor (GO:0051085)2.88958626
52positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.88951552
53regulation of type I interferon-mediated signaling pathway (GO:0060338)2.87854375
54germinal center formation (GO:0002467)2.87837721
55membrane protein intracellular domain proteolysis (GO:0031293)2.84380865
56positive regulation of response to cytokine stimulus (GO:0060760)2.83533277
57negative regulation of stress fiber assembly (GO:0051497)2.80986284
58negative regulation of interleukin-12 production (GO:0032695)2.77879524
59regulation of B cell receptor signaling pathway (GO:0050855)2.73388072
60negative regulation of glycoprotein biosynthetic process (GO:0010561)2.70949972
61cellular response to virus (GO:0098586)2.69992966
62tumor necrosis factor-mediated signaling pathway (GO:0033209)2.69939779
63regulation of gamma-delta T cell activation (GO:0046643)2.69549698
64iron-sulfur cluster assembly (GO:0016226)2.67045398
65metallo-sulfur cluster assembly (GO:0031163)2.67045398
66purine deoxyribonucleotide catabolic process (GO:0009155)2.66917151
67interferon-gamma-mediated signaling pathway (GO:0060333)2.65488301
68cellular response to dsRNA (GO:0071359)2.63750537
69negative regulation of glial cell proliferation (GO:0060253)2.63258047
70negative regulation of lymphocyte mediated immunity (GO:0002707)2.62288294
71lipoxygenase pathway (GO:0019372)2.61794442
72positive regulation of Notch signaling pathway (GO:0045747)2.61637943
73amino sugar catabolic process (GO:0046348)2.61539705
74regulation of superoxide anion generation (GO:0032928)2.60344621
75positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.60140097
76mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.60140097
77positive regulation of chemokine biosynthetic process (GO:0045080)2.58887441
78positive regulation of cholesterol efflux (GO:0010875)2.58770366
79spliceosomal tri-snRNP complex assembly (GO:0000244)2.58520168
80regulation of cholesterol storage (GO:0010885)2.56379356
81alpha-beta T cell differentiation (GO:0046632)2.56254019
82neutrophil activation involved in immune response (GO:0002283)2.56007454
83negative regulation of myotube differentiation (GO:0010832)2.55760274
84positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.55728744
85immunoglobulin mediated immune response (GO:0016064)2.52906893
86defense response to protozoan (GO:0042832)2.52777204
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.52604331
88positive regulation of mitochondrial fission (GO:0090141)2.52461355
89mature B cell differentiation involved in immune response (GO:0002313)2.51828323
90negative regulation of T cell mediated immunity (GO:0002710)2.51699709
91positive regulation of T cell mediated cytotoxicity (GO:0001916)2.50123253
92epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49839062
93regulation of T cell mediated cytotoxicity (GO:0001914)2.49664355
94negative regulation of interleukin-1 beta production (GO:0032691)2.46835484
95positive regulation of keratinocyte differentiation (GO:0045618)2.45890010
96negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.45537597
97amyloid precursor protein catabolic process (GO:0042987)2.45503737
98response to protozoan (GO:0001562)2.45187336
99positive regulation of macrophage differentiation (GO:0045651)2.44535142
100negative thymic T cell selection (GO:0045060)2.42685079

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.30115276
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.19619328
3IRF8_21731497_ChIP-ChIP_J774_Mouse2.78767133
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.72584661
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.58580015
6MYC_22102868_ChIP-Seq_BL_Human2.43580304
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.34787459
8VDR_21846776_ChIP-Seq_THP-1_Human2.31315110
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30404089
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.10353626
11E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.09509264
12MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.05276011
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01293879
14MAF_26560356_Chip-Seq_TH1_Human2.01174838
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99452283
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98893164
17UTX_26944678_Chip-Seq_JUKART_Human1.93436859
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89193249
19MAF_26560356_Chip-Seq_TH2_Human1.88925759
20MYB_26560356_Chip-Seq_TH2_Human1.86606882
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75827995
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74852529
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73651647
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70737440
25SPI1_23547873_ChIP-Seq_NB4_Human1.70421483
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70283391
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68848543
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67762916
29BCL6_27268052_Chip-Seq_Bcells_Human1.67215113
30VDR_24763502_ChIP-Seq_THP-1_Human1.65804758
31LXR_22292898_ChIP-Seq_THP-1_Human1.64336852
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.64167913
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63237296
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62520546
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.60288982
36ELF1_20517297_ChIP-Seq_JURKAT_Human1.58977906
37MYB_26560356_Chip-Seq_TH1_Human1.55274333
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54279573
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.54128344
40BCOR_27268052_Chip-Seq_Bcells_Human1.54116003
41P68_20966046_ChIP-Seq_HELA_Human1.52179666
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50830978
43ZNF274_21170338_ChIP-Seq_K562_Hela1.45230928
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42398960
45CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41044522
46RUNX_20019798_ChIP-Seq_JUKART_Human1.40025738
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39990099
48PU.1_20513432_ChIP-Seq_Bcells_Mouse1.39180756
49GATA1_22025678_ChIP-Seq_K562_Human1.38162013
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36641898
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.34774872
52KDM2B_26808549_Chip-Seq_DND41_Human1.34337724
53PHF8_20622854_ChIP-Seq_HELA_Human1.34313850
54GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33050148
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31020229
56SPI1_23127762_ChIP-Seq_K562_Human1.29928034
57TCF7_22412390_ChIP-Seq_EML_Mouse1.28969914
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28129555
59CTCF_26484167_Chip-Seq_Bcells_Mouse1.23928927
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20936587
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20621742
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20475309
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16878936
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.16000246
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14332371
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13961028
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13951452
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.13782078
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13131322
70SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.12726439
71FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11126161
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10530695
73E2F1_20622854_ChIP-Seq_HELA_Human1.09857224
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.09544628
75P300_27268052_Chip-Seq_Bcells_Human1.08210449
76RACK7_27058665_Chip-Seq_MCF-7_Human1.07177571
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06992043
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06403974
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05751650
80JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05607879
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05355517
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05172149
83GATA3_27048872_Chip-Seq_THYMUS_Human1.05145151
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04592633
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04478379
86PU_27001747_Chip-Seq_BMDM_Mouse1.03658577
87SMC4_20622854_ChIP-Seq_HELA_Human1.03320376
88SPI1_20517297_ChIP-Seq_HL60_Human1.02338372
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01446486
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.01045484
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.00919232
92TP53_22127205_ChIP-Seq_IMR90_Human1.00719381
93MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00158042
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99894909
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99847202
96GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99820087
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99375498
98GABP_19822575_ChIP-Seq_HepG2_Human0.98712696
99CIITA_25753668_ChIP-Seq_RAJI_Human0.97848385
100XRN2_22483619_ChIP-Seq_HELA_Human0.97702625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003191_abnormal_cellular_cholesterol4.26230770
2MP0009840_abnormal_foam_cell3.84962110
3MP0003724_increased_susceptibility_to3.55878665
4MP0002653_abnormal_ependyma_morphology3.28751636
5MP0005058_abnormal_lysosome_morphology3.22241524
6MP0008260_abnormal_autophagy2.91421682
7MP0003436_decreased_susceptibility_to2.88001501
8MP0000685_abnormal_immune_system2.77781084
9MP0003763_abnormal_thymus_physiology2.74569879
10MP0009278_abnormal_bone_marrow2.72554339
11MP0004264_abnormal_extraembryonic_tissu2.71038443
12MP0005387_immune_system_phenotype2.60832643
13MP0001790_abnormal_immune_system2.60832643
14MP0005025_abnormal_response_to2.45698941
15MP0002419_abnormal_innate_immunity2.41508948
16MP0003300_gastrointestinal_ulcer2.38733086
17MP0004381_abnormal_hair_follicle2.36733394
18MP0000858_altered_metastatic_potential2.31760314
19MP0001800_abnormal_humoral_immune2.31693277
20MP0002148_abnormal_hypersensitivity_rea2.29073293
21MP0004947_skin_inflammation2.24817692
22MP0005671_abnormal_response_to2.22747081
23MP0002009_preneoplasia2.20493025
24MP0002723_abnormal_immune_serum2.18781474
25MP0001835_abnormal_antigen_presentation2.18408829
26MP0002452_abnormal_antigen_presenting2.17660603
27MP0003303_peritoneal_inflammation2.13805628
28MP0005000_abnormal_immune_tolerance2.04104939
29MP0009785_altered_susceptibility_to2.03851530
30MP0001819_abnormal_immune_cell1.94059621
31MP0002420_abnormal_adaptive_immunity1.92144601
32MP0002332_abnormal_exercise_endurance1.91280241
33MP0001533_abnormal_skeleton_physiology1.87140501
34MP0009333_abnormal_splenocyte_physiolog1.74243929
35MP0002405_respiratory_system_inflammati1.64275538
36MP0006082_CNS_inflammation1.64108776
37MP0010155_abnormal_intestine_physiology1.61061694
38MP0003646_muscle_fatigue1.58374480
39MP0004510_myositis1.57842728
40MP0000716_abnormal_immune_system1.50588100
41MP0002877_abnormal_melanocyte_morpholog1.48912210
42MP0001845_abnormal_inflammatory_respons1.43100279
43MP0003866_abnormal_defecation1.42959039
44MP0000604_amyloidosis1.40084467
45MP0005310_abnormal_salivary_gland1.36091749
46MP0002398_abnormal_bone_marrow1.35283310
47MP0000689_abnormal_spleen_morphology1.34090138
48MP0009764_decreased_sensitivity_to1.34079483
49MP0003329_amyloid_beta_deposits1.28551558
50MP0002166_altered_tumor_susceptibility1.26568049
51MP0001849_ear_inflammation1.22695324
52MP0002429_abnormal_blood_cell1.21392978
53MP0006072_abnormal_retinal_apoptosis1.21215062
54MP0008961_abnormal_basal_metabolism1.18316931
55MP0005451_abnormal_body_composition1.15724374
56MP0003656_abnormal_erythrocyte_physiolo1.15535546
57MP0008469_abnormal_protein_level1.15481495
58MP0002722_abnormal_immune_system1.11884055
59MP0004742_abnormal_vestibular_system1.08314818
60MP0001873_stomach_inflammation1.05982417
61MP0003448_altered_tumor_morphology1.05906649
62MP0003172_abnormal_lysosome_physiology1.05353768
63MP0000490_abnormal_crypts_of1.04919794
64MP0002254_reproductive_system_inflammat1.03239900
65MP0002132_abnormal_respiratory_system1.00719097
66MP0002998_abnormal_bone_remodeling0.97705595
67MP0002006_tumorigenesis0.97385241
68MP0009763_increased_sensitivity_to0.94922228
69MP0006054_spinal_hemorrhage0.94145359
70MP0005390_skeleton_phenotype0.85604700
71MP0005397_hematopoietic_system_phenotyp0.83004208
72MP0001545_abnormal_hematopoietic_system0.83004208
73MP0001216_abnormal_epidermal_layer0.81973313
74MP0003075_altered_response_to0.80779133
75MP0001853_heart_inflammation0.80778417
76MP0005464_abnormal_platelet_physiology0.80629577
77MP0002098_abnormal_vibrissa_morphology0.78849606
78MP0000343_altered_response_to0.78393896
79MP0003221_abnormal_cardiomyocyte_apopto0.77066630
80MP0000703_abnormal_thymus_morphology0.76210245
81MP0003195_calcinosis0.75707004
82MP0003828_pulmonary_edema0.75615820
83MP0000750_abnormal_muscle_regeneration0.73963654
84MP0003453_abnormal_keratinocyte_physiol0.71705291
85MP0003795_abnormal_bone_structure0.70865181
86MP0001243_abnormal_dermal_layer0.69862091
87MP0002019_abnormal_tumor_incidence0.68557031
88MP0005394_taste/olfaction_phenotype0.68246133
89MP0005499_abnormal_olfactory_system0.68246133
90MP0004133_heterotaxia0.67746105
91MP0002933_joint_inflammation0.66815508
92MP0001915_intracranial_hemorrhage0.65318363
93MP0005167_abnormal_blood-brain_barrier0.64285012
94MP0001986_abnormal_taste_sensitivity0.63408970
95MP0003091_abnormal_cell_migration0.61171480
96MP0000538_abnormal_urinary_bladder0.59783409
97MP0001851_eye_inflammation0.59080417
98MP0000249_abnormal_blood_vessel0.57359876
99MP0004130_abnormal_muscle_cell0.56247382
100MP0000465_gastrointestinal_hemorrhage0.53956166

Predicted human phenotypes

RankGene SetZ-score
1Mutism (HP:0002300)5.05149745
2Pustule (HP:0200039)5.03385728
3Eczematoid dermatitis (HP:0000976)4.43158500
4Recurrent bacterial skin infections (HP:0005406)3.80578417
5Recurrent abscess formation (HP:0002722)3.64692933
6Abnormal tarsal ossification (HP:0008369)3.38357040
7Abnormality of macrophages (HP:0004311)3.36803645
8Myositis (HP:0100614)3.34575115
9Hypoplasia of the pons (HP:0012110)3.32807507
10Hemorrhage of the eye (HP:0011885)3.27546342
11Ragged-red muscle fibers (HP:0003200)3.26453660
12Urethral obstruction (HP:0000796)3.20269413
13Dysostosis multiplex (HP:0000943)3.19942161
14Mediastinal lymphadenopathy (HP:0100721)3.07431916
15Recurrent fungal infections (HP:0002841)3.02841376
16Orchitis (HP:0100796)2.88278762
17Abnormality of the pons (HP:0007361)2.85443371
18Vacuolated lymphocytes (HP:0001922)2.85001432
19Flat acetabular roof (HP:0003180)2.81882111
20Loss of speech (HP:0002371)2.76892625
21Increased IgE level (HP:0003212)2.74086407
22Chronic diarrhea (HP:0002028)2.72560432
23Progressive sensorineural hearing impairment (HP:0000408)2.67602364
24Colon cancer (HP:0003003)2.66944328
25Recurrent skin infections (HP:0001581)2.62879412
26Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.54450776
27Retrobulbar optic neuritis (HP:0100654)2.53731382
28Optic neuritis (HP:0100653)2.53731382
29Stomach cancer (HP:0012126)2.52921399
30Recurrent viral infections (HP:0004429)2.52637450
31Opisthotonus (HP:0002179)2.51014159
32Chronic mucocutaneous candidiasis (HP:0002728)2.47613927
33Recurrent cutaneous fungal infections (HP:0011370)2.47613927
34Cholecystitis (HP:0001082)2.44114460
35Abnormal gallbladder physiology (HP:0012438)2.44114460
36Stomatitis (HP:0010280)2.40138425
37Thick nail (HP:0001805)2.36013482
38Increased cerebral lipofuscin (HP:0011813)2.33087619
39Upper motor neuron abnormality (HP:0002127)2.32835985
40Hepatosplenomegaly (HP:0001433)2.29003387
41Myopathic facies (HP:0002058)2.28853326
42T lymphocytopenia (HP:0005403)2.24439722
43Abnormal foot bone ossification (HP:0010675)2.24323791
44Severe combined immunodeficiency (HP:0004430)2.23787947
45Facial diplegia (HP:0001349)2.22065942
46J-shaped sella turcica (HP:0002680)2.21756123
47Retinal dysplasia (HP:0007973)2.18385275
48Mucopolysacchariduria (HP:0008155)2.18320021
49Urinary glycosaminoglycan excretion (HP:0003541)2.18320021
50External ophthalmoplegia (HP:0000544)2.17773191
51Elevated erythrocyte sedimentation rate (HP:0003565)2.16370385
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.15946265
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.15946265
54Abnormality of polysaccharide metabolism (HP:0011012)2.15946265
55Abnormality of the periventricular white matter (HP:0002518)2.13763225
56Type II lissencephaly (HP:0007260)2.11593828
57Short chin (HP:0000331)2.11441551
58Hematochezia (HP:0002573)2.09222616
59Distal upper limb amyotrophy (HP:0007149)2.07957632
60Upper limb amyotrophy (HP:0009129)2.07957632
61Flattened epiphyses (HP:0003071)2.05652862
62Combined immunodeficiency (HP:0005387)2.05539429
63Cheilitis (HP:0100825)2.04720775
64Progressive neurologic deterioration (HP:0002344)2.03207731
65Recurrent gram-negative bacterial infections (HP:0005420)2.00664344
66Trigonocephaly (HP:0000243)2.00550706
67Spastic tetraparesis (HP:0001285)2.00140906
68Leukocytosis (HP:0001974)1.99020456
69Stridor (HP:0010307)1.96888879
70Interstitial pulmonary disease (HP:0006530)1.95882675
71Hand muscle atrophy (HP:0009130)1.94232292
72Concave nail (HP:0001598)1.93716334
73Microvesicular hepatic steatosis (HP:0001414)1.93083704
74Neuronal loss in central nervous system (HP:0002529)1.92879804
75Abnormality of eosinophils (HP:0001879)1.91461273
76Abnormality of small intestinal villus morphology (HP:0011472)1.90767271
77Villous atrophy (HP:0011473)1.90767271
78Thoracic kyphosis (HP:0002942)1.89504316
79Agammaglobulinemia (HP:0004432)1.87527503
80Broad face (HP:0000283)1.86742385
81Type I transferrin isoform profile (HP:0003642)1.86387962
82Cellulitis (HP:0100658)1.86187336
83Abnormality of the odontoid process (HP:0003310)1.85002764
84Lymphopenia (HP:0001888)1.84486234
85IgG deficiency (HP:0004315)1.83486696
86Axonal loss (HP:0003447)1.83452279
87Bowel incontinence (HP:0002607)1.81311906
88Meningitis (HP:0001287)1.80427713
89Abnormality of T cell number (HP:0011839)1.80290157
90Distal lower limb muscle weakness (HP:0009053)1.80059152
91Hypoalbuminemia (HP:0003073)1.78476206
92Abnormal albumin level (HP:0012116)1.78476206
93Hyperacusis (HP:0010780)1.78418799
94Amyotrophic lateral sclerosis (HP:0007354)1.77382652
95Abnormality of liposaccharide metabolism (HP:0010968)1.76768194
96Abnormality of glycosphingolipid metabolism (HP:0004343)1.76768194
97Abnormality of glycolipid metabolism (HP:0010969)1.76768194
98Diaphragmatic weakness (HP:0009113)1.76692211
99Increased serum ferritin (HP:0003281)1.76382719
100Hypergammaglobulinemia (HP:0010702)1.75520665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.43070332
2TESK23.26382050
3GRK73.23024026
4TAOK33.16383859
5BRD42.95092003
6ERN12.35570298
7MAP4K12.33720484
8SIK32.28911420
9MAPKAPK32.18840606
10MAP3K142.13941028
11EPHA32.00703587
12EPHB11.98090776
13PRPF4B1.96628140
14MAP3K131.81477810
15BLK1.78019083
16GRK61.61226126
17TESK11.60269021
18IRAK31.58064381
19TBK11.53822708
20SIK21.50482488
21EPHA21.50003229
22TRIB31.48818531
23TYK21.44766695
24STK101.38590787
25ICK1.34226817
26CDK61.31642513
27PAK41.30174769
28FGR1.29350137
29KDR1.29290090
30IKBKE1.28132661
31IRAK41.24895990
32ZAP701.22192870
33IKBKB1.21757883
34CSK1.21181779
35MAP3K111.18796736
36CSF1R1.18546258
37BTK1.17770219
38MATK1.07830207
39MST41.05747600
40SIK11.04701391
41MAPK70.99623154
42TRIM280.98592002
43CDC42BPA0.98073223
44RIPK40.97290283
45VRK20.96509440
46MAP2K20.94732983
47TAOK20.92811496
48DAPK10.90576886
49MOS0.89755796
50LYN0.88564806
51SMG10.88429584
52PRKD20.86826385
53LATS10.86363953
54JAK10.83763966
55ADRBK20.82854309
56MAP3K30.81742493
57CHUK0.76825963
58CDK40.76604814
59CDK120.76576001
60CDK90.76104376
61IRAK10.75485554
62MAP2K30.74648149
63NME20.74518936
64MAP3K100.70529450
65RPS6KA40.68783607
66CDK190.68730979
67MAP2K70.63838809
68MAPKAPK20.61891284
69LCK0.61613202
70HCK0.59579842
71CAMKK20.58822822
72JAK30.58454558
73SYK0.58145176
74NLK0.57015717
75TGFBR20.53309192
76TAOK10.50477920
77FYN0.50359174
78TTN0.47202741
79FGFR40.45544893
80DYRK1B0.44179436
81SRPK10.43151037
82MAP2K60.41575879
83LRRK20.40821226
84ITK0.40041387
85MAPK110.39498712
86MST1R0.39062008
87PRKCZ0.34793660
88MAPK150.34121999
89JAK20.31531525
90RPS6KA20.31433487
91DYRK20.30953288
92MET0.30842681
93RPS6KA60.30817312
94DAPK20.30691258
95ADRBK10.29073333
96MAPK30.28643457
97CAMKK10.28487469
98MARK30.27861251
99NEK60.27842980
100HIPK20.27586563

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.16262648
2Other glycan degradation_Homo sapiens_hsa005112.82998064
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.60755159
4Fructose and mannose metabolism_Homo sapiens_hsa000512.42530777
5Osteoclast differentiation_Homo sapiens_hsa043802.37166601
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.31516496
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.27769993
8TNF signaling pathway_Homo sapiens_hsa046681.99013805
9Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.90429352
10Vitamin digestion and absorption_Homo sapiens_hsa049771.89043691
11Allograft rejection_Homo sapiens_hsa053301.86330302
12Legionellosis_Homo sapiens_hsa051341.85820476
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85576157
14Herpes simplex infection_Homo sapiens_hsa051681.80125222
15Notch signaling pathway_Homo sapiens_hsa043301.75672558
16Selenocompound metabolism_Homo sapiens_hsa004501.75450515
17Leishmaniasis_Homo sapiens_hsa051401.74393261
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70968731
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68901275
20Graft-versus-host disease_Homo sapiens_hsa053321.66647933
21Steroid biosynthesis_Homo sapiens_hsa001001.64843844
22Lysosome_Homo sapiens_hsa041421.62030745
23Autoimmune thyroid disease_Homo sapiens_hsa053201.60818399
24Sulfur relay system_Homo sapiens_hsa041221.60533149
25Apoptosis_Homo sapiens_hsa042101.58515515
26Measles_Homo sapiens_hsa051621.57433430
27Primary immunodeficiency_Homo sapiens_hsa053401.57296047
28Hepatitis C_Homo sapiens_hsa051601.56269445
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54087420
30Tuberculosis_Homo sapiens_hsa051521.51098574
31Staphylococcus aureus infection_Homo sapiens_hsa051501.50098885
32Influenza A_Homo sapiens_hsa051641.45919266
33Base excision repair_Homo sapiens_hsa034101.44464172
34Viral myocarditis_Homo sapiens_hsa054161.38078574
35Hematopoietic cell lineage_Homo sapiens_hsa046401.36925552
36Shigellosis_Homo sapiens_hsa051311.35817185
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.32969065
38Salmonella infection_Homo sapiens_hsa051321.29422892
39Pertussis_Homo sapiens_hsa051331.28143051
40Acute myeloid leukemia_Homo sapiens_hsa052211.25902912
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24254734
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.21885380
43Epstein-Barr virus infection_Homo sapiens_hsa051691.18517962
44Galactose metabolism_Homo sapiens_hsa000521.15257180
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15073849
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.12752065
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09041592
48Bladder cancer_Homo sapiens_hsa052191.08878779
49Type I diabetes mellitus_Homo sapiens_hsa049401.08781087
50B cell receptor signaling pathway_Homo sapiens_hsa046621.05220902
51Antigen processing and presentation_Homo sapiens_hsa046121.01737070
52Hepatitis B_Homo sapiens_hsa051611.01248587
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00989514
54Toxoplasmosis_Homo sapiens_hsa051451.00256821
55Malaria_Homo sapiens_hsa051441.00074401
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.98540360
57Rheumatoid arthritis_Homo sapiens_hsa053230.98466604
58Phagosome_Homo sapiens_hsa041450.97207645
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93282561
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91919027
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88305672
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87396180
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87361445
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.84127520
65Asthma_Homo sapiens_hsa053100.82572062
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81891965
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79043442
68Sphingolipid metabolism_Homo sapiens_hsa006000.73305089
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72323541
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.71978424
71Viral carcinogenesis_Homo sapiens_hsa052030.71115918
72T cell receptor signaling pathway_Homo sapiens_hsa046600.61832641
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60835203
74Regulation of autophagy_Homo sapiens_hsa041400.54491709
75Chemokine signaling pathway_Homo sapiens_hsa040620.53826463
76Ether lipid metabolism_Homo sapiens_hsa005650.50112010
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.47172130
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46051716
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43380552
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.42616956
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41647265
82Linoleic acid metabolism_Homo sapiens_hsa005910.40811447
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38696326
84Pancreatic cancer_Homo sapiens_hsa052120.35708674
85HTLV-I infection_Homo sapiens_hsa051660.33724318
86Small cell lung cancer_Homo sapiens_hsa052220.31963496
87Endocytosis_Homo sapiens_hsa041440.29731823
88Lysine degradation_Homo sapiens_hsa003100.28181061
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26694329
90HIF-1 signaling pathway_Homo sapiens_hsa040660.26208555
91Spliceosome_Homo sapiens_hsa030400.25443574
92Fat digestion and absorption_Homo sapiens_hsa049750.24828047
93Insulin resistance_Homo sapiens_hsa049310.24670740
94Renin-angiotensin system_Homo sapiens_hsa046140.24149221
95Vibrio cholerae infection_Homo sapiens_hsa051100.23112159
96African trypanosomiasis_Homo sapiens_hsa051430.21695329
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21446091
98Colorectal cancer_Homo sapiens_hsa052100.19447827
99Biosynthesis of amino acids_Homo sapiens_hsa012300.18231746
100Arachidonic acid metabolism_Homo sapiens_hsa005900.18207770

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