UPP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)8.57498560
2L-phenylalanine catabolic process (GO:0006559)7.73341665
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.73341665
4L-phenylalanine metabolic process (GO:0006558)7.37756568
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.37756568
6aromatic amino acid family catabolic process (GO:0009074)6.95115155
7indole-containing compound catabolic process (GO:0042436)6.24388771
8indolalkylamine catabolic process (GO:0046218)6.24388771
9tryptophan catabolic process (GO:0006569)6.24388771
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.21373829
11kynurenine metabolic process (GO:0070189)6.10007567
12bile acid biosynthetic process (GO:0006699)5.96449826
13tryptophan metabolic process (GO:0006568)5.87086421
14urea cycle (GO:0000050)5.75592735
15urea metabolic process (GO:0019627)5.75592735
16glyoxylate metabolic process (GO:0046487)5.62734687
17alpha-linolenic acid metabolic process (GO:0036109)5.54443779
18high-density lipoprotein particle remodeling (GO:0034375)5.52013483
19negative regulation of fibrinolysis (GO:0051918)5.47672905
20protein carboxylation (GO:0018214)5.35589347
21peptidyl-glutamic acid carboxylation (GO:0017187)5.35589347
22regulation of fibrinolysis (GO:0051917)5.30992242
23nitrogen cycle metabolic process (GO:0071941)5.29203598
24oxidative demethylation (GO:0070989)5.23844483
25sulfur amino acid catabolic process (GO:0000098)5.22327156
26complement activation, alternative pathway (GO:0006957)5.20687391
27cysteine metabolic process (GO:0006534)5.20324937
28regulation of protein activation cascade (GO:2000257)5.17176505
29bile acid metabolic process (GO:0008206)5.13177032
30serine family amino acid catabolic process (GO:0009071)5.09216860
31aromatic amino acid family metabolic process (GO:0009072)5.05930913
32ethanol metabolic process (GO:0006067)4.98947099
33tyrosine metabolic process (GO:0006570)4.90590142
34regulation of cholesterol esterification (GO:0010872)4.84238142
35regulation of complement activation (GO:0030449)4.84204883
36homocysteine metabolic process (GO:0050667)4.81538118
37phenylpropanoid metabolic process (GO:0009698)4.79668937
38reverse cholesterol transport (GO:0043691)4.73624312
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.73140422
40alpha-amino acid catabolic process (GO:1901606)4.72958404
41regulation of triglyceride catabolic process (GO:0010896)4.72534630
42protein-lipid complex remodeling (GO:0034368)4.69222507
43macromolecular complex remodeling (GO:0034367)4.69222507
44plasma lipoprotein particle remodeling (GO:0034369)4.69222507
45lysine catabolic process (GO:0006554)4.66612379
46lysine metabolic process (GO:0006553)4.66612379
47negative regulation of sterol transport (GO:0032372)4.66065568
48negative regulation of cholesterol transport (GO:0032375)4.66065568
49amino-acid betaine metabolic process (GO:0006577)4.60489361
50acylglycerol homeostasis (GO:0055090)4.53922954
51triglyceride homeostasis (GO:0070328)4.53922954
52S-adenosylmethionine metabolic process (GO:0046500)4.53364029
53phospholipid efflux (GO:0033700)4.48022295
54coenzyme catabolic process (GO:0009109)4.45939621
55indolalkylamine metabolic process (GO:0006586)4.45551241
56drug catabolic process (GO:0042737)4.42481264
57cellular ketone body metabolic process (GO:0046950)4.40157146
58cellular glucuronidation (GO:0052695)4.40049079
59bile acid and bile salt transport (GO:0015721)4.39476485
60imidazole-containing compound metabolic process (GO:0052803)4.35756280
61cellular biogenic amine catabolic process (GO:0042402)4.34070310
62amine catabolic process (GO:0009310)4.34070310
63cellular amino acid catabolic process (GO:0009063)4.33788613
64glutamate metabolic process (GO:0006536)4.30783947
65glycine metabolic process (GO:0006544)4.28929963
66plasma lipoprotein particle clearance (GO:0034381)4.28421028
67negative regulation of protein activation cascade (GO:2000258)4.22118521
68benzene-containing compound metabolic process (GO:0042537)4.21688002
69cholesterol efflux (GO:0033344)4.20645317
70serine family amino acid metabolic process (GO:0009069)4.10728590
71cellular modified amino acid catabolic process (GO:0042219)4.10424252
72arginine metabolic process (GO:0006525)4.08654394
73dicarboxylic acid biosynthetic process (GO:0043650)4.07554509
74ethanol oxidation (GO:0006069)4.04165252
75epoxygenase P450 pathway (GO:0019373)3.99177283
76exogenous drug catabolic process (GO:0042738)3.98480109
77regulation of bile acid biosynthetic process (GO:0070857)3.95767305
78aldehyde catabolic process (GO:0046185)3.94178538
79low-density lipoprotein particle remodeling (GO:0034374)3.93218747
80fibrinolysis (GO:0042730)3.92322672
81alkaloid metabolic process (GO:0009820)3.92027175
82uronic acid metabolic process (GO:0006063)3.90927532
83glucuronate metabolic process (GO:0019585)3.90927532
84plasma lipoprotein particle assembly (GO:0034377)3.90732723
85serine family amino acid biosynthetic process (GO:0009070)3.89472247
86negative regulation of complement activation (GO:0045916)3.87790898
87cofactor catabolic process (GO:0051187)3.84695904
88negative regulation of lipase activity (GO:0060192)3.81203493
89flavonoid metabolic process (GO:0009812)3.81007627
90ketone body metabolic process (GO:1902224)3.80989339
91L-methionine salvage (GO:0071267)3.78790112
92L-methionine biosynthetic process (GO:0071265)3.78790112
93amino acid salvage (GO:0043102)3.78790112
94blood coagulation, intrinsic pathway (GO:0007597)3.77113067
95carboxylic acid catabolic process (GO:0046395)3.76961227
96organic acid catabolic process (GO:0016054)3.76961227
97pyrimidine nucleobase catabolic process (GO:0006208)3.76858913
98positive regulation of lipid catabolic process (GO:0050996)3.76791534
99short-chain fatty acid metabolic process (GO:0046459)3.76638604
100regulation of plasminogen activation (GO:0010755)3.75793200
101cholesterol homeostasis (GO:0042632)3.71976786
102very-low-density lipoprotein particle assembly (GO:0034379)3.71168381
103acetyl-CoA metabolic process (GO:0006084)3.70575739
104drug metabolic process (GO:0017144)3.69279519
105complement activation, classical pathway (GO:0006958)3.68501767
106phospholipid homeostasis (GO:0055091)3.68429480
107complement activation (GO:0006956)3.66948143
108sterol homeostasis (GO:0055092)3.65940454
109protein activation cascade (GO:0072376)3.64364722
110NAD biosynthetic process (GO:0009435)3.60608333
111regulation of cholesterol homeostasis (GO:2000188)3.59488024
112positive regulation of triglyceride lipase activity (GO:0061365)3.59107204
113positive regulation of lipoprotein lipase activity (GO:0051006)3.59107204
114sodium-independent organic anion transport (GO:0043252)3.54086958
115regulation of humoral immune response (GO:0002920)3.43907696
116nucleobase catabolic process (GO:0046113)3.36872455
117negative regulation of blood coagulation (GO:0030195)3.26617967
118negative regulation of hemostasis (GO:1900047)3.26617967
119disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.22575813
120killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.22575813
121dicarboxylic acid catabolic process (GO:0043649)3.17341787
122opsonization (GO:0008228)3.16260937
123xenobiotic catabolic process (GO:0042178)3.16229150
124gamma-aminobutyric acid transport (GO:0015812)3.15964727
125xenobiotic metabolic process (GO:0006805)3.12849441
126indole-containing compound metabolic process (GO:0042430)3.08364535
127C4-dicarboxylate transport (GO:0015740)3.04176972
128methionine metabolic process (GO:0006555)3.03649415

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.33719065
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.08240834
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.86508235
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.47017172
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.36598281
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.97662789
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.73475291
8EZH2_22144423_ChIP-Seq_EOC_Human4.10620169
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97687786
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.89400216
11GBX2_23144817_ChIP-Seq_PC3_Human3.88697994
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28854621
13ZNF274_21170338_ChIP-Seq_K562_Hela2.22786684
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10459920
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10189755
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8475731
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97788051
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97611931
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91817862
20IRF1_19129219_ChIP-ChIP_H3396_Human1.91028860
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90758040
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.86555354
23VDR_22108803_ChIP-Seq_LS180_Human1.83279653
24IGF1R_20145208_ChIP-Seq_DFB_Human1.78560339
25* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78120153
26SMAD4_21799915_ChIP-Seq_A2780_Human1.77274248
27STAT3_23295773_ChIP-Seq_U87_Human1.75052634
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71585242
29P300_19829295_ChIP-Seq_ESCs_Human1.70715659
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63811487
31REST_21632747_ChIP-Seq_MESCs_Mouse1.63484487
32TCF4_23295773_ChIP-Seq_U87_Human1.62773661
33* FOXA2_19822575_ChIP-Seq_HepG2_Human1.61005468
34HTT_18923047_ChIP-ChIP_STHdh_Human1.60258393
35ER_23166858_ChIP-Seq_MCF-7_Human1.55708017
36DROSHA_22980978_ChIP-Seq_HELA_Human1.52118043
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52099302
38CLOCK_20551151_ChIP-Seq_293T_Human1.51058000
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50032857
40AR_25329375_ChIP-Seq_VCAP_Human1.49756939
41* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47043232
42GATA1_22025678_ChIP-Seq_K562_Human1.44904868
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40581257
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40581257
45AR_21572438_ChIP-Seq_LNCaP_Human1.38899115
46TCF4_22108803_ChIP-Seq_LS180_Human1.38686966
47* HNF4A_19822575_ChIP-Seq_HepG2_Human1.38615142
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36095424
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35274255
50CBP_20019798_ChIP-Seq_JUKART_Human1.35274255
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34412874
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32675288
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31795624
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27720624
55RUNX2_22187159_ChIP-Seq_PCA_Human1.26373246
56KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25409240
57* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24379030
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.22842477
59NANOG_19829295_ChIP-Seq_ESCs_Human1.21149266
60SOX2_19829295_ChIP-Seq_ESCs_Human1.21149266
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18729069
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.16133142
63RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14773288
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14648303
65* REST_18959480_ChIP-ChIP_MESCs_Mouse1.13016837
66* CDX2_22108803_ChIP-Seq_LS180_Human1.11063412
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08480186
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07299267
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.07123677
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06672399
71EWS_26573619_Chip-Seq_HEK293_Human1.06615091
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06409544
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06129614
74KDM2B_26808549_Chip-Seq_REH_Human1.05888771
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04636375
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04579797
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04361483
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.04179166
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.03584968
80* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02542335
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02144697
82* SMAD4_21741376_ChIP-Seq_EPCs_Human1.02106038
83SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01979066
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01269743
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01251822
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.00931033
87TP53_16413492_ChIP-PET_HCT116_Human1.00745337
88* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00637824
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.00125339
90* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98558953
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95021459
92* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93993095
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93852907
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93779052
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93704599
96FOXA1_25329375_ChIP-Seq_VCAP_Human0.93304519
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93304519
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92839782
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92822043
100SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89387698
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88284728
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86901674
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85064383
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81905011
105* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81471508
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.81263344
107RARG_19884340_ChIP-ChIP_MEFs_Mouse0.77301822
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76504685
109GATA4_25053715_ChIP-Seq_YYC3_Human0.74901055
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74753935
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74496727
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72261668
113RARA_24833708_ChIP-Seq_LIVER_Mouse0.71380384
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71029821
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69399371
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69399371
117IRF8_22096565_ChIP-ChIP_GC-B_Human0.68521773
118ZNF263_19887448_ChIP-Seq_K562_Human0.68505395
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67845288
120TAF15_26573619_Chip-Seq_HEK293_Human0.66656898
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.66025583
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65798289
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65261190
124RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61715724
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61500374
126GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.60785956
127RARB_24833708_ChIP-Seq_LIVER_Mouse0.59226688
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58822274
129CEBPB_22108803_ChIP-Seq_LS180_Human0.56479231
130EGR1_19032775_ChIP-ChIP_M12_Human0.55784228
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55158497
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.54167745
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.53918823
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.53195383
135FOXA1_25552417_ChIP-Seq_VCAP_Human0.53094845
136LXR_22292898_ChIP-Seq_THP-1_Human0.53034715
137MYC_19915707_ChIP-ChIP_AK7_Human0.52701882
138ERG_21242973_ChIP-ChIP_JURKAT_Human0.52468246
139CBP_21632823_ChIP-Seq_H3396_Human0.52338758
140AR_20517297_ChIP-Seq_VCAP_Human0.51264625
141FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50651994
142STAT1_17558387_ChIP-Seq_HELA_Human0.49687891
143ESET_19884257_ChIP-Seq_ESCs_Mouse0.48404840
144BCAT_22108803_ChIP-Seq_LS180_Human0.46872927
145FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46496411
146PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44765324
147* P53_21459846_ChIP-Seq_SAOS-2_Human0.44712968
148CDX2_20551321_ChIP-Seq_CACO-2_Human0.44471636
149CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.43860766
150MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.43642175
151SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42993219
152PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42494008
153ESR1_20079471_ChIP-ChIP_T-47D_Human0.41039471
154GATA1_19941826_ChIP-Seq_K562_Human0.40292848
155ESR1_21235772_ChIP-Seq_MCF-7_Human0.39941059
156TAF2_19829295_ChIP-Seq_ESCs_Human0.39700508
157BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.39414215
158SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.39247106
159MYC_27129775_Chip-Seq_CORNEA_Mouse0.39241377
160GATA1_19941827_ChIP-Seq_MEL_Mouse0.39164478
161LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.38156460
162PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.38053193
163STAT3_1855785_ChIP-Seq_MESCs_Mouse0.37829373
164NCOR_22424771_ChIP-Seq_293T_Human0.37518361
165ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.37061699
166FOXO3_23340844_ChIP-Seq_DLD1_Human0.36848840
167PPAR_26484153_Chip-Seq_NCI-H1993_Human0.36312616
168FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.36148073
169EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.36092511
170PIAS1_25552417_ChIP-Seq_VCAP_Human0.35256664
171SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.35077419
172* GATA2_19941826_ChIP-Seq_K562_Human0.35072522
173FOXH1_21741376_ChIP-Seq_EPCs_Human0.34971565

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.41092035
2MP0005360_urolithiasis7.62468864
3MP0005085_abnormal_gallbladder_physiolo6.54820154
4MP0005365_abnormal_bile_salt6.14428197
5MP0008875_abnormal_xenobiotic_pharmacok5.52627013
6MP0003806_abnormal_nucleotide_metabolis4.04194878
7MP0003252_abnormal_bile_duct3.89775407
8MP0010329_abnormal_lipoprotein_level3.54335242
9MP0009840_abnormal_foam_cell3.19052795
10MP0005083_abnormal_biliary_tract3.06005888
11MP0003195_calcinosis2.89655062
12MP0005332_abnormal_amino_acid2.80779214
13MP0001666_abnormal_nutrient_absorption2.57231542
14MP0003879_abnormal_hair_cell2.50667737
15MP0004019_abnormal_vitamin_homeostasis2.16207304
16MP0005551_abnormal_eye_electrophysiolog2.15393944
17MP0001984_abnormal_olfaction2.12882209
18MP0000609_abnormal_liver_physiology2.12022484
19MP0003191_abnormal_cellular_cholesterol2.11399671
20MP0008877_abnormal_DNA_methylation2.11112824
21MP0002118_abnormal_lipid_homeostasis2.10505549
22MP0002102_abnormal_ear_morphology2.08206799
23MP0002653_abnormal_ependyma_morphology2.08131927
24MP0009046_muscle_twitch2.04166989
25MP0003868_abnormal_feces_composition1.95083395
26MP0002138_abnormal_hepatobiliary_system1.89788335
27MP0005319_abnormal_enzyme/_coenzyme1.81944221
28MP0006292_abnormal_olfactory_placode1.73228619
29MP0001486_abnormal_startle_reflex1.67938607
30MP0001764_abnormal_homeostasis1.67481255
31MP0005377_hearing/vestibular/ear_phenot1.67198658
32MP0003878_abnormal_ear_physiology1.67198658
33MP0009745_abnormal_behavioral_response1.63540804
34MP0003880_abnormal_central_pattern1.58283500
35MP0005584_abnormal_enzyme/coenzyme_acti1.56753384
36MP0009697_abnormal_copulation1.55836917
37MP0003183_abnormal_peptide_metabolism1.53641385
38MP0001968_abnormal_touch/_nociception1.49915017
39MP0003136_yellow_coat_color1.48779881
40MP0002064_seizures1.45972566
41MP0002272_abnormal_nervous_system1.41782186
42MP0005451_abnormal_body_composition1.39291771
43MP0001986_abnormal_taste_sensitivity1.36055528
44MP0001501_abnormal_sleep_pattern1.31057679
45MP0002735_abnormal_chemical_nociception1.29301170
46MP0003011_delayed_dark_adaptation1.26172521
47MP0001485_abnormal_pinna_reflex1.25517999
48MP0003656_abnormal_erythrocyte_physiolo1.24160366
49MP0009780_abnormal_chondrocyte_physiolo1.22803766
50MP0009643_abnormal_urine_homeostasis1.22627347
51MP0003186_abnormal_redox_activity1.19988754
52MP0002736_abnormal_nociception_after1.19567989
53MP0005423_abnormal_somatic_nervous1.19290096
54MP0003635_abnormal_synaptic_transmissio1.18233594
55MP0000598_abnormal_liver_morphology1.14870633
56MP0004859_abnormal_synaptic_plasticity1.14356675
57MP0004142_abnormal_muscle_tone1.12275102
58MP0002572_abnormal_emotion/affect_behav1.11775290
59MP0005647_abnormal_sex_gland1.09834355
60MP0000604_amyloidosis1.07347217
61MP0005646_abnormal_pituitary_gland1.06587986
62MP0002063_abnormal_learning/memory/cond1.04413528
63MP0009764_decreased_sensitivity_to1.03867192
64MP0004043_abnormal_pH_regulation1.03635290
65MP0003705_abnormal_hypodermis_morpholog1.03188363
66MP0003633_abnormal_nervous_system1.02587534
67MP0004270_analgesia1.00764395
68MP0005670_abnormal_white_adipose1.00406883
69MP0009763_increased_sensitivity_to0.98893081
70MP0002254_reproductive_system_inflammat0.97604017
71MP0006072_abnormal_retinal_apoptosis0.97077433
72MP0005386_behavior/neurological_phenoty0.93631605
73MP0004924_abnormal_behavior0.93631605
74MP0005253_abnormal_eye_physiology0.92954484
75MP0002132_abnormal_respiratory_system0.90882042
76MP0005636_abnormal_mineral_homeostasis0.90418279
77MP0010368_abnormal_lymphatic_system0.89403111
78MP0005410_abnormal_fertilization0.88790199
79MP0002067_abnormal_sensory_capabilities0.87666472
80MP0004742_abnormal_vestibular_system0.86644183
81MP0009642_abnormal_blood_homeostasis0.86234382
82MP0008057_abnormal_DNA_replication0.85103930
83MP0002229_neurodegeneration0.85037475
84MP0001963_abnormal_hearing_physiology0.84386115
85MP0008469_abnormal_protein_level0.84253486
86MP0002876_abnormal_thyroid_physiology0.83351129
87MP0005408_hypopigmentation0.81520123
88MP0006036_abnormal_mitochondrial_physio0.81255511
89MP0005084_abnormal_gallbladder_morpholo0.80420564
90MP0006276_abnormal_autonomic_nervous0.79832539
91MP0009765_abnormal_xenobiotic_induced0.79668726
92MP0002078_abnormal_glucose_homeostasis0.79489688
93MP0005376_homeostasis/metabolism_phenot0.78330700
94MP0002557_abnormal_social/conspecific_i0.76645555
95MP0003631_nervous_system_phenotype0.76010593
96MP0004130_abnormal_muscle_cell0.75425159
97MP0003698_abnormal_male_reproductive0.75097639
98MP0005535_abnormal_body_temperature0.74944802
99MP0001502_abnormal_circadian_rhythm0.74038510
100MP0003329_amyloid_beta_deposits0.73659944
101MP0003690_abnormal_glial_cell0.73139674
102MP0001440_abnormal_grooming_behavior0.72755944
103MP0002971_abnormal_brown_adipose0.72403914
104MP0002734_abnormal_mechanical_nocicepti0.70003534
105MP0005334_abnormal_fat_pad0.69337285
106MP0005220_abnormal_exocrine_pancreas0.68849039
107MP0010386_abnormal_urinary_bladder0.67036914
108MP0004885_abnormal_endolymph0.66120552
109MP0002822_catalepsy0.65864300
110MP0005266_abnormal_metabolism0.63982559
111MP0001661_extended_life_span0.63780008
112MP0003632_abnormal_nervous_system0.63254470
113MP0001970_abnormal_pain_threshold0.62003202
114MP0000639_abnormal_adrenal_gland0.60021413
115MP0001756_abnormal_urination0.58896461
116MP0000569_abnormal_digit_pigmentation0.58607384
117MP0009053_abnormal_anal_canal0.58564233
118MP0002160_abnormal_reproductive_system0.57426505
119MP0008874_decreased_physiological_sensi0.56958207
120MP0005448_abnormal_energy_balance0.56473327
121MP0006035_abnormal_mitochondrial_morpho0.54373103
122MP0008872_abnormal_physiological_respon0.52755747
123MP0003638_abnormal_response/metabolism_0.50284840
124MP0002837_dystrophic_cardiac_calcinosis0.49812877
125MP0008873_increased_physiological_sensi0.46100230
126MP0005464_abnormal_platelet_physiology0.45937149
127MP0005395_other_phenotype0.44738392
128MP0002928_abnormal_bile_duct0.44175457
129MP0004782_abnormal_surfactant_physiolog0.43649969
130MP0002136_abnormal_kidney_physiology0.42826745
131MP0003075_altered_response_to0.42796747
132MP0003953_abnormal_hormone_level0.42730860
133MP0003718_maternal_effect0.41456594
134MP0005248_abnormal_Harderian_gland0.40494496
135MP0005666_abnormal_adipose_tissue0.39616783
136MP0009672_abnormal_birth_weight0.38410208
137MP0005166_decreased_susceptibility_to0.36131556
138MP0000579_abnormal_nail_morphology0.35567662
139MP0003724_increased_susceptibility_to0.35439542
140MP0000230_abnormal_systemic_arterial0.33758177
141MP0002090_abnormal_vision0.33576136
142MP0003436_decreased_susceptibility_to0.32524865
143MP0009115_abnormal_fat_cell0.31652815
144MP0002168_other_aberrant_phenotype0.30877043
145MP0004883_abnormal_blood_vessel0.29234886
146MP0002970_abnormal_white_adipose0.28912934
147MP0000249_abnormal_blood_vessel0.28724248
148MP0001243_abnormal_dermal_layer0.28397219
149MP0009384_cardiac_valve_regurgitation0.27913984
150MP0001881_abnormal_mammary_gland0.27562629
151MP0001853_heart_inflammation0.26406067
152MP0005167_abnormal_blood-brain_barrier0.24791348
153MP0004381_abnormal_hair_follicle0.24667493
154MP0002796_impaired_skin_barrier0.23670688
155MP0001845_abnormal_inflammatory_respons0.21866014
156MP0005058_abnormal_lysosome_morphology0.21392576
157MP0005187_abnormal_penis_morphology0.20897434
158MP0005164_abnormal_response_to0.20296201

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.66570157
2Deep venous thrombosis (HP:0002625)7.45759679
3Intrahepatic cholestasis (HP:0001406)7.21341023
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.82041848
5Prolonged partial thromboplastin time (HP:0003645)6.61452603
6Hypobetalipoproteinemia (HP:0003563)6.39189014
7Xanthomatosis (HP:0000991)6.23642149
8Hyperlipoproteinemia (HP:0010980)5.62291063
9Complement deficiency (HP:0004431)5.20394901
10Hypolipoproteinemia (HP:0010981)4.75459656
11Joint hemorrhage (HP:0005261)4.75005627
12Hyperammonemia (HP:0001987)4.64069102
13Epidermoid cyst (HP:0200040)4.57995427
14Abnormality of methionine metabolism (HP:0010901)4.38968185
15Ketosis (HP:0001946)4.38663765
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.35957569
17Hyperglycinemia (HP:0002154)4.35307343
18Abnormality of the common coagulation pathway (HP:0010990)4.32222333
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.28643042
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.25903955
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.20583212
22Hypoalphalipoproteinemia (HP:0003233)4.16203299
23Fat malabsorption (HP:0002630)4.01601664
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.99155475
25Abnormality of pyrimidine metabolism (HP:0004353)3.96318084
26Hyperglycinuria (HP:0003108)3.91861556
27Abnormality of glycine metabolism (HP:0010895)3.90429511
28Abnormality of serine family amino acid metabolism (HP:0010894)3.90429511
29Hypoglycemic coma (HP:0001325)3.79571118
30Abnormality of complement system (HP:0005339)3.76907204
31Abnormality of the intrinsic pathway (HP:0010989)3.75038030
32Conjugated hyperbilirubinemia (HP:0002908)3.74716081
33Hypercholesterolemia (HP:0003124)3.73727698
34Hyperbilirubinemia (HP:0002904)3.36547605
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.34322391
36Abnormality of fatty-acid metabolism (HP:0004359)3.27154734
37Delayed CNS myelination (HP:0002188)3.19067490
38Abnormality of nucleobase metabolism (HP:0010932)3.11693978
39Fair hair (HP:0002286)3.09678895
40Abnormality of serum amino acid levels (HP:0003112)3.09047903
41Ketoacidosis (HP:0001993)3.06813211
42Steatorrhea (HP:0002570)3.03303715
43Myocardial infarction (HP:0001658)2.92107383
44Hepatocellular carcinoma (HP:0001402)2.91042302
45Skin nodule (HP:0200036)2.85072836
46Spontaneous abortion (HP:0005268)2.83856612
47Hypochromic microcytic anemia (HP:0004840)2.83120571
48Focal motor seizures (HP:0011153)2.76797457
49Metabolic acidosis (HP:0001942)2.74942734
50Abnormality of purine metabolism (HP:0004352)2.69381926
51Systemic lupus erythematosus (HP:0002725)2.66346600
52Lethargy (HP:0001254)2.63198673
53Vascular calcification (HP:0004934)2.60435207
54Osteomalacia (HP:0002749)2.60090771
55Abnormal respiratory motile cilium physiology (HP:0012261)2.56352196
56Cerebral edema (HP:0002181)2.53245154
57Dicarboxylic aciduria (HP:0003215)2.51057240
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51057240
59Abnormal gallbladder morphology (HP:0012437)2.50221284
60Mitral stenosis (HP:0001718)2.50185987
61Hypoglycemic seizures (HP:0002173)2.49522194
62Acanthocytosis (HP:0001927)2.48541147
63Spastic diplegia (HP:0001264)2.48102228
64Pigmentary retinal degeneration (HP:0001146)2.47442050
65Irritability (HP:0000737)2.45193608
66Gout (HP:0001997)2.44244330
67Cholelithiasis (HP:0001081)2.42314034
68Focal seizures (HP:0007359)2.42248370
69Neonatal onset (HP:0003623)2.41689188
70Glomerulonephritis (HP:0000099)2.41597298
71Hypomagnesemia (HP:0002917)2.38856903
72Polydipsia (HP:0001959)2.37158614
73Abnormal drinking behavior (HP:0030082)2.37158614
74Atonic seizures (HP:0010819)2.37089333
75Cholecystitis (HP:0001082)2.35578800
76Abnormal gallbladder physiology (HP:0012438)2.35578800
77Gaze-evoked nystagmus (HP:0000640)2.30691239
78Cardiovascular calcification (HP:0011915)2.30516928
79Rhinitis (HP:0012384)2.30120386
80Increased circulating renin level (HP:0000848)2.28572601
81Polyuria (HP:0000103)2.28566244
82Cerebral hypomyelination (HP:0006808)2.26509136
83Nephritis (HP:0000123)2.26182900
84Chronic bronchitis (HP:0004469)2.24208010
85Hyperventilation (HP:0002883)2.23411511
86Febrile seizures (HP:0002373)2.21328521
87Abnormal urine output (HP:0012590)2.20236381
88Recurrent gram-negative bacterial infections (HP:0005420)2.19594538
89Brushfield spots (HP:0001088)2.19425984
90Myokymia (HP:0002411)2.18689920
91Amyloidosis (HP:0011034)2.18252243
92Progressive cerebellar ataxia (HP:0002073)2.16563039
93Late onset (HP:0003584)2.14118790
94Menorrhagia (HP:0000132)2.13481580
95Sensorimotor neuropathy (HP:0007141)2.11853679
96Generalized hypopigmentation of hair (HP:0011358)2.11211078
97Esophageal varix (HP:0002040)2.10003043
98Malnutrition (HP:0004395)2.09688800
99Epileptic encephalopathy (HP:0200134)2.08656606
100Pancreatitis (HP:0001733)2.08363300
101Enlarged kidneys (HP:0000105)2.08117653
102Metabolic alkalosis (HP:0200114)2.06453109
103Vomiting (HP:0002013)2.06401504
104Absence seizures (HP:0002121)2.06285204
105Attenuation of retinal blood vessels (HP:0007843)2.05681961
106Gingival bleeding (HP:0000225)2.04544754
107Poikilocytosis (HP:0004447)2.03409098
108Hyperinsulinemic hypoglycemia (HP:0000825)2.03006047
109Abnormality of the gallbladder (HP:0005264)2.01828240
110Opisthotonus (HP:0002179)2.01385095
111Pancreatic cysts (HP:0001737)1.99861088
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98837649
113Abnormality of alanine metabolism (HP:0010916)1.98837649
114Hyperalaninemia (HP:0003348)1.98837649
115Hemiparesis (HP:0001269)1.98486131
116Generalized aminoaciduria (HP:0002909)1.98097969
117Status epilepticus (HP:0002133)1.97969134
118Thrombophlebitis (HP:0004418)1.96463532
119Hemorrhage of the eye (HP:0011885)1.96407506
120Alkalosis (HP:0001948)1.94834661
121Agammaglobulinemia (HP:0004432)1.94293005
122Occipital encephalocele (HP:0002085)1.93107043
123Hypophosphatemic rickets (HP:0004912)1.92771513
124Nephrogenic diabetes insipidus (HP:0009806)1.92547385
125Rickets (HP:0002748)1.91895164
126True hermaphroditism (HP:0010459)1.91154857
127Hydroxyprolinuria (HP:0003080)1.90479889
128Abnormality of proline metabolism (HP:0010907)1.90479889
129Hypokalemic alkalosis (HP:0001949)1.90103244
130Medial flaring of the eyebrow (HP:0010747)1.89990783
131Dialeptic seizures (HP:0011146)1.88709283
132Bile duct proliferation (HP:0001408)1.88055380
133Abnormal biliary tract physiology (HP:0012439)1.88055380
134Abnormal cartilage morphology (HP:0002763)1.86879984
135Gait imbalance (HP:0002141)1.86750983
136Hyperglycemia (HP:0003074)1.85661677
137Abnormality of iron homeostasis (HP:0011031)1.84410100
138Abnormality of renal excretion (HP:0011036)1.82537321
139Abnormality of transition element cation homeostasis (HP:0011030)1.81484616
140Chronic hepatic failure (HP:0100626)1.81103261
141Renal cortical cysts (HP:0000803)1.79519997
142Thyroiditis (HP:0100646)1.79443944
143Reticulocytosis (HP:0001923)1.77796821
144Absent speech (HP:0001344)1.77631517
145Abnormal enzyme/coenzyme activity (HP:0012379)1.77571366
146Generalized tonic-clonic seizures (HP:0002069)1.77159799
147Elevated hepatic transaminases (HP:0002910)1.75651293
148Pancreatic fibrosis (HP:0100732)1.74830591
149Delayed myelination (HP:0012448)1.74024784
150Congenital primary aphakia (HP:0007707)1.73960290
151Acute hepatic failure (HP:0006554)1.73562194
152Hyperaldosteronism (HP:0000859)1.73548226
153Neonatal hypoglycemia (HP:0001998)1.72633193
154Abolished electroretinogram (ERG) (HP:0000550)1.72216130

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.15475072
2SIK14.68747489
3FGFR44.36623502
4ERN13.84761552
5WNK33.65296012
6INSRR3.18697470
7TAOK32.94443809
8ERBB42.92593795
9NTRK32.87059677
10MAP2K42.70759133
11PKN22.41482491
12MAP4K22.34416802
13PNCK2.30754778
14CAMKK22.14669512
15MST1R2.10539982
16KIT2.09348404
17FLT31.91073642
18ACVR1B1.89149341
19MAPK111.84891709
20OXSR11.79254140
21DAPK21.78377178
22TRIB31.65974191
23PIK3CG1.62432908
24TNK21.54837580
25ABL21.51692156
26TYK21.50978390
27MARK11.48521742
28BMPR1B1.48010293
29LATS11.47936769
30FGFR21.47062479
31MAPK131.44186598
32CASK1.38699289
33NUAK11.38654189
34SIK21.37520877
35FRK1.34951520
36PTK61.34474339
37PINK11.28554411
38MAP3K71.28295005
39JAK21.23716290
40EPHA41.22591911
41KDR1.15343075
42NEK91.13708099
43PRKAA21.13209333
44GRK61.11125478
45ADRBK21.08936847
46NTRK21.08765479
47ARAF1.07497072
48STK381.06959199
49TXK1.05478502
50ERBB21.03312749
51MAPK41.03190619
52PRKCE1.02848381
53PRKCZ1.02530239
54ZAK1.02298808
55MAPKAPK31.01657049
56JAK10.97550482
57PLK20.97227677
58MAP2K30.95379612
59MAP3K140.92439915
60TNIK0.92252658
61TBK10.92087834
62CAMK10.90418498
63MAPK120.88568513
64CDK190.88229566
65TIE10.86160428
66CAMK2A0.86139780
67PTK2B0.85377765
68DYRK1A0.84107357
69CAMK2G0.82947340
70MINK10.81492586
71DAPK10.80181110
72PRKACG0.79801417
73MAP2K60.79331965
74MET0.79222264
75MAP3K120.76023675
76STK38L0.75443449
77SGK30.73500624
78MAP3K100.72500575
79PDK20.72393718
80MAPK150.72188358
81MAP3K130.71888775
82GRK70.71820662
83MAP3K30.69855868
84MAP3K110.69804917
85CDK60.68890321
86PRKACA0.68535930
87CSK0.68293842
88CAMK2D0.68216557
89CAMK1D0.68140882
90DYRK20.67320508
91STK30.67176486
92FER0.66959199
93EPHB10.66894854
94PRKAA10.65074745
95CDK50.64730494
96MAPK70.62448987
97SGK10.61782882
98GSK3A0.61350541
99EPHA30.61315550
100DYRK1B0.60852944
101CSNK1D0.60747613
102RET0.60384038
103PDPK10.60258243
104BCR0.60184397
105RAF10.59970438
106PRKG10.58457944
107RIPK10.57659130
108SGK20.56844663
109PAK60.56844627
110PRKCG0.56629073
111TAOK20.55947679
112CSNK1A10.55906703
113ADRBK10.55551071
114CAMK2B0.54552381
115RPS6KA30.53924714
116PRKCQ0.53650478
117PTK20.53343890
118NLK0.52679419
119PHKG20.52255705
120PHKG10.52255705
121FGFR30.51951207
122CSNK1G10.51572704
123CDK30.50317924
124TEC0.50271034
125MAP2K10.50250354
126MAP3K50.47805270
127IKBKE0.47717307
128PRKACB0.47399530
129MAP3K90.47311751
130SYK0.46464926
131IGF1R0.45758309
132EIF2AK30.45627991
133PRKCB0.45573293
134BMPR20.44858786
135SGK4940.43971628
136SGK2230.43971628
137TGFBR20.43743396
138PKN10.43162508
139PDK10.42928367
140CSF1R0.42639976
141CSNK1G20.42142469
142IRAK30.40042325
143ICK0.38818859
144GRK10.38802320
145MAP3K60.38659549
146MAP3K10.37774632
147LATS20.35889106
148MAP3K40.35761411
149EGFR0.35564068
150CAMK40.34667523
151MAP3K20.33699534
152PRKCA0.32615685
153PIK3CA0.32547909
154IRAK20.32337495
155PAK30.32291458
156CAMKK10.31070154
157CSNK1G30.29806327
158CAMK1G0.29798694
159KSR20.28848803
160PDK30.27959740
161PDK40.27959740
162MTOR0.26349737

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.50421701
2Nitrogen metabolism_Homo sapiens_hsa009103.61939285
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.52695411
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.44060112
5Arginine biosynthesis_Homo sapiens_hsa002203.15321965
6Tryptophan metabolism_Homo sapiens_hsa003802.74083678
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67839411
8Complement and coagulation cascades_Homo sapiens_hsa046102.66822297
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.54996275
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50060315
11Fatty acid degradation_Homo sapiens_hsa000712.41324529
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34020331
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32084193
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.22921993
15Butanoate metabolism_Homo sapiens_hsa006502.13785500
16Steroid hormone biosynthesis_Homo sapiens_hsa001402.04677461
17Caffeine metabolism_Homo sapiens_hsa002322.04298902
18Peroxisome_Homo sapiens_hsa041462.03769054
19Chemical carcinogenesis_Homo sapiens_hsa052042.02619249
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.00942791
21Histidine metabolism_Homo sapiens_hsa003401.91307409
22Propanoate metabolism_Homo sapiens_hsa006401.88914252
23PPAR signaling pathway_Homo sapiens_hsa033201.84038682
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.79346799
25Retinol metabolism_Homo sapiens_hsa008301.73668226
26Fatty acid metabolism_Homo sapiens_hsa012121.73232770
27beta-Alanine metabolism_Homo sapiens_hsa004101.69154741
28Staphylococcus aureus infection_Homo sapiens_hsa051501.68499461
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65569046
30Phenylalanine metabolism_Homo sapiens_hsa003601.60895261
31* Drug metabolism - other enzymes_Homo sapiens_hsa009831.60477202
32Selenocompound metabolism_Homo sapiens_hsa004501.55064815
33Bile secretion_Homo sapiens_hsa049761.54434961
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52976344
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52135028
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51660754
37Tyrosine metabolism_Homo sapiens_hsa003501.42866474
38Pyruvate metabolism_Homo sapiens_hsa006201.35851828
39Starch and sucrose metabolism_Homo sapiens_hsa005001.31552265
40Sulfur metabolism_Homo sapiens_hsa009201.31391680
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.30948401
42Fatty acid elongation_Homo sapiens_hsa000621.23265092
43Biosynthesis of amino acids_Homo sapiens_hsa012301.21160785
44ABC transporters_Homo sapiens_hsa020101.20726395
45Folate biosynthesis_Homo sapiens_hsa007901.15601238
46Steroid biosynthesis_Homo sapiens_hsa001001.15535971
47Fat digestion and absorption_Homo sapiens_hsa049751.10845290
48Carbon metabolism_Homo sapiens_hsa012001.09414084
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02765727
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.00153120
51Arginine and proline metabolism_Homo sapiens_hsa003300.97080584
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95528657
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.94909665
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92631524
55Sulfur relay system_Homo sapiens_hsa041220.87012297
56Nicotine addiction_Homo sapiens_hsa050330.83738250
57Vitamin B6 metabolism_Homo sapiens_hsa007500.83337668
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83316365
59Lysine degradation_Homo sapiens_hsa003100.78216167
60Vitamin digestion and absorption_Homo sapiens_hsa049770.77840031
61Phototransduction_Homo sapiens_hsa047440.75013500
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69057135
63Glycerolipid metabolism_Homo sapiens_hsa005610.67848481
64GABAergic synapse_Homo sapiens_hsa047270.65555957
65One carbon pool by folate_Homo sapiens_hsa006700.65296673
66Glutathione metabolism_Homo sapiens_hsa004800.61398074
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61055503
68Glutamatergic synapse_Homo sapiens_hsa047240.58432480
69Pentose phosphate pathway_Homo sapiens_hsa000300.51922468
70Fatty acid biosynthesis_Homo sapiens_hsa000610.49828785
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49212320
72Insulin secretion_Homo sapiens_hsa049110.48743082
73Serotonergic synapse_Homo sapiens_hsa047260.46509844
74Circadian entrainment_Homo sapiens_hsa047130.45662351
75* Metabolic pathways_Homo sapiens_hsa011000.44196418
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39376146
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37476532
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37339614
79Taste transduction_Homo sapiens_hsa047420.35404856
80Morphine addiction_Homo sapiens_hsa050320.33205780
81Prion diseases_Homo sapiens_hsa050200.33109740
82Olfactory transduction_Homo sapiens_hsa047400.32884947
83Amphetamine addiction_Homo sapiens_hsa050310.29572579
84Salivary secretion_Homo sapiens_hsa049700.24579562
85Linoleic acid metabolism_Homo sapiens_hsa005910.23802909
86Insulin resistance_Homo sapiens_hsa049310.23087968
87Fructose and mannose metabolism_Homo sapiens_hsa000510.22135772
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.21648892
89Galactose metabolism_Homo sapiens_hsa000520.21301758
90Cocaine addiction_Homo sapiens_hsa050300.20778661
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20666806
92Dorso-ventral axis formation_Homo sapiens_hsa043200.16965639
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.16335373
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.16113976
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15964957
96Circadian rhythm_Homo sapiens_hsa047100.14702715
97Glucagon signaling pathway_Homo sapiens_hsa049220.14374311
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14182923
99Dopaminergic synapse_Homo sapiens_hsa047280.14178882
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.13358105
101Non-homologous end-joining_Homo sapiens_hsa034500.12813375
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.09510139
103Cholinergic synapse_Homo sapiens_hsa047250.09301033
104Calcium signaling pathway_Homo sapiens_hsa040200.08873391
105Long-term depression_Homo sapiens_hsa047300.08342432
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.08153014
107Gastric acid secretion_Homo sapiens_hsa049710.08139002
108AMPK signaling pathway_Homo sapiens_hsa041520.03221999
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2375494
110Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2321227
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2285432
112Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2172255
113Type II diabetes mellitus_Homo sapiens_hsa04930-0.2170705
114Renin-angiotensin system_Homo sapiens_hsa04614-0.2157872
115Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2113463
116Hepatitis C_Homo sapiens_hsa05160-0.2084601
117Arachidonic acid metabolism_Homo sapiens_hsa00590-0.2032657
118Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1906649
119Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1649042
120Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1612773
121Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1548571
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1526614
123African trypanosomiasis_Homo sapiens_hsa05143-0.1365599
124Regulation of autophagy_Homo sapiens_hsa04140-0.1304867
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1236697
126Insulin signaling pathway_Homo sapiens_hsa04910-0.0827484
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0593138
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0380856
129Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0281915

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »