UQCC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein that is structurally similar to the mouse basic fibroblast growth factor repressed ZIC-binding protein. In mouse this protein may be involved in fibroblast growth factor regulated growth control. In humans, polymorphisms in this gene are associated with variation in human height and osteoarthritis. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)7.97776339
2NADH metabolic process (GO:0006734)6.80015752
3regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)6.24323875
4regulation of acyl-CoA biosynthetic process (GO:0050812)5.70685523
5regulation of cofactor metabolic process (GO:0051193)5.27554286
6regulation of coenzyme metabolic process (GO:0051196)5.27554286
7carnitine shuttle (GO:0006853)5.16309908
8succinate metabolic process (GO:0006105)5.14379960
9sarcomere organization (GO:0045214)5.10677522
102-oxoglutarate metabolic process (GO:0006103)4.98172535
11oxaloacetate metabolic process (GO:0006107)4.95631928
12branched-chain amino acid catabolic process (GO:0009083)4.81102003
13lysine metabolic process (GO:0006553)4.74702939
14lysine catabolic process (GO:0006554)4.74702939
15oxidative phosphorylation (GO:0006119)4.65932430
16fatty acid transmembrane transport (GO:1902001)4.64534412
17muscle filament sliding (GO:0030049)4.54849782
18actin-myosin filament sliding (GO:0033275)4.54849782
19regulation of sulfur metabolic process (GO:0042762)4.42882576
20aspartate family amino acid catabolic process (GO:0009068)4.42776384
21cardiac myofibril assembly (GO:0055003)4.42710265
22positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.42141455
23regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.31993984
24fatty acid beta-oxidation (GO:0006635)4.30636749
25ubiquinone biosynthetic process (GO:0006744)4.26487859
26quinone biosynthetic process (GO:1901663)4.26487859
27biotin metabolic process (GO:0006768)4.26168448
28branched-chain amino acid metabolic process (GO:0009081)4.23189994
29myofibril assembly (GO:0030239)4.22128712
30cardiac muscle contraction (GO:0060048)4.13077521
31negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.10715453
32regulation of skeletal muscle contraction (GO:0014819)4.06033338
33mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.05849613
34respiratory electron transport chain (GO:0022904)4.00995614
35regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.00756830
36respiratory chain complex IV assembly (GO:0008535)4.00521208
37negative regulation of potassium ion transmembrane transport (GO:1901380)3.96605866
38regulation of sequestering of triglyceride (GO:0010889)3.95016709
39carnitine transmembrane transport (GO:1902603)3.91685205
40electron transport chain (GO:0022900)3.89891695
41* regulation of mitochondrial translation (GO:0070129)3.88596557
42tricarboxylic acid metabolic process (GO:0072350)3.86531515
43valine metabolic process (GO:0006573)3.81504867
44regulation of relaxation of muscle (GO:1901077)3.78232264
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.76415864
46aerobic respiration (GO:0009060)3.73694990
47amino-acid betaine transport (GO:0015838)3.72390930
48carnitine transport (GO:0015879)3.72390930
49fatty acid catabolic process (GO:0009062)3.71640308
50cardiac muscle hypertrophy (GO:0003300)3.70608311
51* cytochrome complex assembly (GO:0017004)3.70043139
52heart process (GO:0003015)3.67089994
53heart contraction (GO:0060047)3.67089994
54actin-mediated cell contraction (GO:0070252)3.66775042
55regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.63093237
56sarcoplasmic reticulum calcium ion transport (GO:0070296)3.62025927
57ubiquinone metabolic process (GO:0006743)3.62007262
58striated muscle contraction (GO:0006941)3.61975420
59regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.60571825
60fatty acid oxidation (GO:0019395)3.59756864
61monoubiquitinated protein deubiquitination (GO:0035520)3.58046030
62carnitine metabolic process (GO:0009437)3.56614255
63lipid oxidation (GO:0034440)3.55764600
64cardiac muscle cell development (GO:0055013)3.53864869
65regulation of fatty acid oxidation (GO:0046320)3.52397895
66striated muscle hypertrophy (GO:0014897)3.49936887
67water-soluble vitamin biosynthetic process (GO:0042364)3.45377300
68purine nucleobase biosynthetic process (GO:0009113)3.44214440
69ventricular cardiac muscle cell action potential (GO:0086005)3.40456716
70energy coupled proton transport, down electrochemical gradient (GO:0015985)3.37175406
71ATP synthesis coupled proton transport (GO:0015986)3.37175406
72amino-acid betaine metabolic process (GO:0006577)3.35252608
73fatty acid homeostasis (GO:0055089)3.33296203
74regulation of membrane repolarization (GO:0060306)3.32687307
75acetyl-CoA metabolic process (GO:0006084)3.29597975
76cardiac cell development (GO:0055006)3.27031941
77NAD metabolic process (GO:0019674)3.24586545
78pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.24113122
79monocarboxylic acid catabolic process (GO:0072329)3.23675259
80pseudouridine synthesis (GO:0001522)3.22754751
81short-chain fatty acid metabolic process (GO:0046459)3.21882166
82cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20172010
83regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.18795238
84cellular respiration (GO:0045333)3.17867847
85gluconeogenesis (GO:0006094)3.16435832
86viral mRNA export from host cell nucleus (GO:0046784)3.13910322
87muscle hypertrophy (GO:0014896)3.13376186
88base-excision repair, AP site formation (GO:0006285)3.12767433
89actomyosin structure organization (GO:0031032)3.12369296
90plasma membrane repair (GO:0001778)3.11869591
91regulation of actin filament-based movement (GO:1903115)3.10934379
92maturation of 5.8S rRNA (GO:0000460)3.10085402
93hexose biosynthetic process (GO:0019319)3.08601780
94inner mitochondrial membrane organization (GO:0007007)3.06891322
95replication fork processing (GO:0031297)3.04940954
96cellular ketone body metabolic process (GO:0046950)3.04822353
97glycogen catabolic process (GO:0005980)3.04298189
98L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.04113749
99regulation of cell communication by electrical coupling (GO:0010649)3.03824748
100regulation of sarcomere organization (GO:0060297)2.99188786
101ribosome assembly (GO:0042255)2.98105682
102skeletal muscle contraction (GO:0003009)2.97337189
103* protein complex biogenesis (GO:0070271)2.96672519
104quaternary ammonium group transport (GO:0015697)2.92702001
105cardiac muscle cell action potential involved in contraction (GO:0086002)2.92163592
106peptidyl-histidine modification (GO:0018202)2.90347756
107regulation of hexokinase activity (GO:1903299)2.88797459
108regulation of glucokinase activity (GO:0033131)2.88797459
109IMP biosynthetic process (GO:0006188)2.88249491
110cardiac muscle cell action potential (GO:0086001)2.88190675
111mitochondrial RNA metabolic process (GO:0000959)2.88060752
112nucleobase biosynthetic process (GO:0046112)2.87355814
113dicarboxylic acid catabolic process (GO:0043649)2.87244691
114response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.83660490
115* mitochondrial respiratory chain complex assembly (GO:0033108)2.83309824
116tRNA aminoacylation for protein translation (GO:0006418)2.82987472
117glucan catabolic process (GO:0009251)2.82721185
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.81866081
119ketone body metabolic process (GO:1902224)2.81789779
120pyrimidine ribonucleoside catabolic process (GO:0046133)2.81709898
121glucan biosynthetic process (GO:0009250)2.81285744
122glycogen biosynthetic process (GO:0005978)2.81285744
123aspartate family amino acid biosynthetic process (GO:0009067)2.79609156
124mitochondrial respiratory chain complex I assembly (GO:0032981)2.79410582
125NADH dehydrogenase complex assembly (GO:0010257)2.79410582
126mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.79410582
127protein deneddylation (GO:0000338)2.77046388
128regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.75076007
129tRNA aminoacylation (GO:0043039)2.73949460
130amino acid activation (GO:0043038)2.73949460
131pyrimidine nucleotide catabolic process (GO:0006244)2.73153593
132erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.72157596
133L-phenylalanine metabolic process (GO:0006558)2.72157596
134positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.69417162
135negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.68363401
136rRNA modification (GO:0000154)2.67858023
137methionine biosynthetic process (GO:0009086)2.64720336
138misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.61709171
139positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.61392571
140proteasome assembly (GO:0043248)2.61017489
141L-methionine salvage (GO:0071267)2.59421247
142L-methionine biosynthetic process (GO:0071265)2.59421247
143amino acid salvage (GO:0043102)2.59421247
144L-phenylalanine catabolic process (GO:0006559)2.56132584
145erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.56132584
146anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.54041262
147cullin deneddylation (GO:0010388)2.53897042
148regulation of cellular amino acid metabolic process (GO:0006521)2.53235350
149transcription from mitochondrial promoter (GO:0006390)2.49823656
150negative regulation of ligase activity (GO:0051352)2.43129757
151negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.43129757
152positive regulation of ligase activity (GO:0051351)2.42177919
153regulation of cilium movement (GO:0003352)2.41203989
154rRNA methylation (GO:0031167)2.40164303
155AMP metabolic process (GO:0046033)2.35673082
156GMP metabolic process (GO:0046037)2.34082745
157IMP metabolic process (GO:0046040)2.33646760
158resolution of meiotic recombination intermediates (GO:0000712)2.32923877
159glutamine metabolic process (GO:0006541)2.32514862
160DNA strand renaturation (GO:0000733)2.31459552
161aspartate family amino acid metabolic process (GO:0009066)2.31161542
162DNA double-strand break processing (GO:0000729)2.31048637
163iron-sulfur cluster assembly (GO:0016226)2.30686455
164metallo-sulfur cluster assembly (GO:0031163)2.30686455
165regulation of ubiquitin-protein transferase activity (GO:0051438)2.30612862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.37247120
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.75845521
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.56486030
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.04959193
5E2F7_22180533_ChIP-Seq_HELA_Human3.59572144
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59087613
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.38136502
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32589184
9SRF_21415370_ChIP-Seq_HL-1_Mouse3.12781530
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.11615832
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.97155275
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.90639939
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.58277173
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.56965249
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.55506157
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.38157554
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.32432377
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29312747
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.28450036
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23123292
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21565883
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.18858880
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16761187
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12528955
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.08592745
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.06962605
27YY1_21170310_ChIP-Seq_MESCs_Mouse2.06881729
28MYC_18555785_ChIP-Seq_MESCs_Mouse2.04607465
29GATA4_21415370_ChIP-Seq_HL-1_Mouse2.03917436
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.98898521
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.92510572
32ELK1_19687146_ChIP-ChIP_HELA_Human1.91955780
33ZNF274_21170338_ChIP-Seq_K562_Hela1.89259611
34BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.88148842
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80001469
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77144615
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75784905
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75587744
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.74393016
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.73654928
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58907971
42PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.57788509
43GABP_19822575_ChIP-Seq_HepG2_Human1.57498512
44NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.56819685
45CIITA_25753668_ChIP-Seq_RAJI_Human1.56074575
46IGF1R_20145208_ChIP-Seq_DFB_Human1.55929664
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53678886
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53192152
49VDR_22108803_ChIP-Seq_LS180_Human1.51975638
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.51136492
51GATA1_22025678_ChIP-Seq_K562_Human1.45777313
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45103639
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44888284
54TTF2_22483619_ChIP-Seq_HELA_Human1.41109102
55TBX20_22328084_ChIP-Seq_HEART_Mouse1.37125755
56TBX20_22080862_ChIP-Seq_HEART_Mouse1.37125755
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.36896983
58MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.35880193
59NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.35673122
60TBX5_21415370_ChIP-Seq_HL-1_Mouse1.34088870
61TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.33915168
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33441178
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32960599
64DCP1A_22483619_ChIP-Seq_HELA_Human1.32138381
65FOXP3_21729870_ChIP-Seq_TREG_Human1.27677333
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27597210
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.26051332
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25130221
69SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.24977934
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24833347
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22704261
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.21513235
73VDR_23849224_ChIP-Seq_CD4+_Human1.20168159
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19816856
75SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16787735
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08732775
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08194057
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08032058
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07249450
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04982670
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.04099130
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00040899
83MYC_18940864_ChIP-ChIP_HL60_Human0.98063565
84MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97774117
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97368607
86TFEB_21752829_ChIP-Seq_HELA_Human0.96919226
87PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96916283
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96752160
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96670798
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96171553
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95196615
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94660259
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.91665643
94CLOCK_20551151_ChIP-Seq_293T_Human0.91603659
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91095593
96SOX17_20123909_ChIP-Seq_XEN_Mouse0.90044016
97ESR1_20079471_ChIP-ChIP_T-47D_Human0.89863021
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.89535863
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88730897
100RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87696381
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87276098
102TET1_21451524_ChIP-Seq_MESCs_Mouse0.87004307
103XRN2_22483619_ChIP-Seq_HELA_Human0.85015223
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.84957732
105CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84797242
106KDM5A_27292631_Chip-Seq_BREAST_Human0.84691101
107NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84231189
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83942825
109HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83539931
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83021976
111IRF1_19129219_ChIP-ChIP_H3396_Human0.82816987
112BCL6_27268052_Chip-Seq_Bcells_Human0.81590779
113RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81476062
114AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81464725
115ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81454707
116NCOR_22424771_ChIP-Seq_293T_Human0.81383046
117P68_20966046_ChIP-Seq_HELA_Human0.80994665
118ZNF263_19887448_ChIP-Seq_K562_Human0.80890612
119ZFP57_27257070_Chip-Seq_ESCs_Mouse0.80399956
120FUS_26573619_Chip-Seq_HEK293_Human0.79785118
121CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79509615
122AR_21909140_ChIP-Seq_LNCAP_Human0.79372018
123POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78194733
124MYC_19079543_ChIP-ChIP_MESCs_Mouse0.77755077
125POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.77720409
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77478628
127TAF2_19829295_ChIP-Seq_ESCs_Human0.76078712
128ERA_21632823_ChIP-Seq_H3396_Human0.76017752
129ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74301800
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.73744775
131PHF8_20622854_ChIP-Seq_HELA_Human0.73139982
132CTCF_18555785_ChIP-Seq_MESCs_Mouse0.72756135
133HTT_18923047_ChIP-ChIP_STHdh_Human0.72369858
134EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.71024421
135RARA_24833708_ChIP-Seq_LIVER_Mouse0.68361927
136CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.67825675
137RXRA_24833708_ChIP-Seq_LIVER_Mouse0.67138135

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.20893941
2MP0002837_dystrophic_cardiac_calcinosis5.28072229
3MP0004084_abnormal_cardiac_muscle4.18183059
4MP0000751_myopathy4.07604655
5MP0004215_abnormal_myocardial_fiber3.86043620
6MP0000749_muscle_degeneration3.53715604
7MP0004036_abnormal_muscle_relaxation3.36537616
8MP0005330_cardiomyopathy3.17969236
9MP0004130_abnormal_muscle_cell3.17566614
10MP0006036_abnormal_mitochondrial_physio3.16156398
11MP0005670_abnormal_white_adipose2.53168092
12MP0003806_abnormal_nucleotide_metabolis2.51800503
13MP0002269_muscular_atrophy2.49194077
14MP0004087_abnormal_muscle_fiber2.42960568
15MP0005085_abnormal_gallbladder_physiolo2.34813695
16MP0002139_abnormal_hepatobiliary_system2.28563308
17MP0006035_abnormal_mitochondrial_morpho2.28116582
18MP0003221_abnormal_cardiomyocyte_apopto2.26774447
19MP0002972_abnormal_cardiac_muscle2.25466489
20MP0005620_abnormal_muscle_contractility2.19263375
21MP0008775_abnormal_heart_ventricle2.15448055
22MP0003137_abnormal_impulse_conducting2.12720872
23MP0002106_abnormal_muscle_physiology2.10370808
24MP0005365_abnormal_bile_salt2.09788464
25MP0000747_muscle_weakness2.04594481
26MP0010094_abnormal_chromosome_stability2.01409714
27MP0005385_cardiovascular_system_phenoty2.01242771
28MP0001544_abnormal_cardiovascular_syste2.01242771
29MP0003950_abnormal_plasma_membrane1.98057284
30MP0000750_abnormal_muscle_regeneration1.97635540
31MP0004145_abnormal_muscle_electrophysio1.95428860
32MP0004484_altered_response_of1.88564016
33MP0003122_maternal_imprinting1.84567132
34MP0006138_congestive_heart_failure1.84378238
35MP0004233_abnormal_muscle_weight1.80820609
36MP0005332_abnormal_amino_acid1.76997970
37MP0010630_abnormal_cardiac_muscle1.75969275
38MP0005369_muscle_phenotype1.72607976
39MP0004147_increased_porphyrin_level1.69409084
40MP0000759_abnormal_skeletal_muscle1.64096369
41MP0005360_urolithiasis1.62154593
42MP0005083_abnormal_biliary_tract1.61171317
43MP0005666_abnormal_adipose_tissue1.58143012
44MP0002332_abnormal_exercise_endurance1.54275053
45MP0005408_hypopigmentation1.48009126
46MP0001984_abnormal_olfaction1.46686127
47MP0009840_abnormal_foam_cell1.41338866
48MP0003195_calcinosis1.38022988
49MP0003786_premature_aging1.37433529
50MP0004085_abnormal_heartbeat1.36402580
51MP0002127_abnormal_cardiovascular_syste1.36077108
52MP0002938_white_spotting1.33855708
53MP0005266_abnormal_metabolism1.33332165
54MP0005319_abnormal_enzyme/_coenzyme1.31806259
55MP0006072_abnormal_retinal_apoptosis1.30773017
56MP0008007_abnormal_cellular_replicative1.29861455
57MP0001764_abnormal_homeostasis1.29816351
58MP0010329_abnormal_lipoprotein_level1.29657778
59MP0000372_irregular_coat_pigmentation1.27485741
60MP0008875_abnormal_xenobiotic_pharmacok1.25412065
61MP0004043_abnormal_pH_regulation1.25270458
62MP0009046_muscle_twitch1.23444624
63MP0002822_catalepsy1.15050341
64MP0001529_abnormal_vocalization1.13872057
65MP0003186_abnormal_redox_activity1.13602429
66MP0008057_abnormal_DNA_replication1.09568630
67MP0003077_abnormal_cell_cycle1.08821548
68MP0002971_abnormal_brown_adipose1.08604917
69MP0004270_analgesia1.08111199
70MP0003656_abnormal_erythrocyte_physiolo1.08067867
71MP0009697_abnormal_copulation1.07911162
72MP0008932_abnormal_embryonic_tissue1.07647877
73MP0004957_abnormal_blastocyst_morpholog1.06627657
74MP0005584_abnormal_enzyme/coenzyme_acti1.05932531
75MP0005535_abnormal_body_temperature1.03575069
76MP0002118_abnormal_lipid_homeostasis1.01568360
77MP0005551_abnormal_eye_electrophysiolog0.99833556
78MP0002078_abnormal_glucose_homeostasis0.99543669
79MP0000013_abnormal_adipose_tissue0.98124758
80MP0003828_pulmonary_edema0.97091297
81MP0005410_abnormal_fertilization0.96421935
82MP0002876_abnormal_thyroid_physiology0.92375303
83MP0003123_paternal_imprinting0.89774640
84MP0001346_abnormal_lacrimal_gland0.85578211
85MP0005375_adipose_tissue_phenotype0.84690936
86MP0002909_abnormal_adrenal_gland0.84429721
87MP0004133_heterotaxia0.84043910
88MP0005253_abnormal_eye_physiology0.83918579
89MP0009780_abnormal_chondrocyte_physiolo0.82492058
90MP0001968_abnormal_touch/_nociception0.81845400
91MP0004185_abnormal_adipocyte_glucose0.81208831
92MP0003121_genomic_imprinting0.81097035
93MP0002102_abnormal_ear_morphology0.80587603
94MP0000230_abnormal_systemic_arterial0.80489700
95MP0008260_abnormal_autophagy0.79812161
96MP0000003_abnormal_adipose_tissue0.76767563
97MP0001905_abnormal_dopamine_level0.76155543
98MP0001730_embryonic_growth_arrest0.74706229
99MP0003567_abnormal_fetal_cardiomyocyte0.74109259
100MP0000343_altered_response_to0.73867991
101MP0000609_abnormal_liver_physiology0.73766082
102MP0000358_abnormal_cell_content/0.73432008
103MP0009643_abnormal_urine_homeostasis0.71694183
104MP0000427_abnormal_hair_cycle0.70750774
105MP0000266_abnormal_heart_morphology0.69598606
106MP0005379_endocrine/exocrine_gland_phen0.68253953
107MP0005451_abnormal_body_composition0.66491835
108MP0001697_abnormal_embryo_size0.65980303
109MP0005334_abnormal_fat_pad0.65925347
110MP0005645_abnormal_hypothalamus_physiol0.64822505
111MP0008789_abnormal_olfactory_epithelium0.64490810
112MP0001929_abnormal_gametogenesis0.64134502
113MP0003937_abnormal_limbs/digits/tail_de0.63852371
114MP0002108_abnormal_muscle_morphology0.62836826
115MP0002163_abnormal_gland_morphology0.60601350
116MP0005376_homeostasis/metabolism_phenot0.60357726
117MP0001986_abnormal_taste_sensitivity0.58604775
118MP0005386_behavior/neurological_phenoty0.58503548
119MP0004924_abnormal_behavior0.58503548
120MP0003252_abnormal_bile_duct0.58333020
121MP0002160_abnormal_reproductive_system0.58211188
122MP0003698_abnormal_male_reproductive0.58122657
123MP0004019_abnormal_vitamin_homeostasis0.57844376
124MP0002090_abnormal_vision0.56626273
125MP0001672_abnormal_embryogenesis/_devel0.55532431
126MP0002638_abnormal_pupillary_reflex0.53963093
127MP0009672_abnormal_birth_weight0.53570309
128MP0005165_increased_susceptibility_to0.51356054
129MP0005452_abnormal_adipose_tissue0.51350452
130MP0003953_abnormal_hormone_level0.50692138
131MP0001756_abnormal_urination0.50609203
132MP0002970_abnormal_white_adipose0.50578555
133MP0002736_abnormal_nociception_after0.50021593
134MP0008058_abnormal_DNA_repair0.48999356
135MP0003191_abnormal_cellular_cholesterol0.47683727
136MP0003111_abnormal_nucleus_morphology0.47551788
137MP0001661_extended_life_span0.47377403
138MP0005448_abnormal_energy_balance0.46962151
139MP0003718_maternal_effect0.45472354
140MP0001666_abnormal_nutrient_absorption0.44218511
141MP0005636_abnormal_mineral_homeostasis0.43039471
142MP0009115_abnormal_fat_cell0.42933505
143MP0003693_abnormal_embryo_hatching0.42761963

Predicted human phenotypes

RankGene SetZ-score
1Cutaneous melanoma (HP:0012056)5.50838653
2Exercise-induced myalgia (HP:0003738)5.34205176
3Myoglobinuria (HP:0002913)5.09554093
4Exercise-induced muscle cramps (HP:0003710)4.56041638
5Sudden death (HP:0001699)4.49993738
6Hepatic necrosis (HP:0002605)4.39643775
7Rhabdomyolysis (HP:0003201)4.23169341
8Calf muscle hypertrophy (HP:0008981)4.13042035
9Palpitations (HP:0001962)4.12615843
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.02780020
11Abnormality of alanine metabolism (HP:0010916)4.02780020
12Hyperalaninemia (HP:0003348)4.02780020
13Hyperglycinuria (HP:0003108)3.95662081
14Abnormal mitochondria in muscle tissue (HP:0008316)3.92497846
15Hepatocellular necrosis (HP:0001404)3.92006261
16Abnormality of fatty-acid metabolism (HP:0004359)3.86401698
17Muscle hypertrophy of the lower extremities (HP:0008968)3.79019946
18Ventricular tachycardia (HP:0004756)3.74150000
19Dicarboxylic aciduria (HP:0003215)3.71696978
20Abnormality of dicarboxylic acid metabolism (HP:0010995)3.71696978
21Ketoacidosis (HP:0001993)3.59861926
22Muscle fiber splitting (HP:0003555)3.58851226
23Acute necrotizing encephalopathy (HP:0006965)3.58686883
24Pheochromocytoma (HP:0002666)3.53886992
25Hypoglycemic coma (HP:0001325)3.48230557
26Acute encephalopathy (HP:0006846)3.46533203
27Atrial fibrillation (HP:0005110)3.45905182
28Abnormality of glycine metabolism (HP:0010895)3.42592642
29Abnormality of serine family amino acid metabolism (HP:0010894)3.42592642
30Bundle branch block (HP:0011710)3.40900992
31Increased CSF lactate (HP:0002490)3.37066548
32Lactic acidosis (HP:0003128)3.31665922
33Cerebral edema (HP:0002181)3.30965659
34Increased muscle lipid content (HP:0009058)3.30861199
35Ketosis (HP:0001946)3.30297467
36Hyperglycinemia (HP:0002154)3.28153741
37Decreased activity of mitochondrial respiratory chain (HP:0008972)3.26195035
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.26195035
39Mitochondrial inheritance (HP:0001427)3.23904003
40Hyperammonemia (HP:0001987)3.21671375
41Neuroendocrine neoplasm (HP:0100634)3.20301243
42Lipoatrophy (HP:0100578)3.16346397
43Primary atrial arrhythmia (HP:0001692)3.16256290
44Abnormality of the calf musculature (HP:0001430)3.15348816
45Ragged-red muscle fibers (HP:0003200)3.14097601
46Supraventricular tachycardia (HP:0004755)3.12080477
47Dilated cardiomyopathy (HP:0001644)3.06683777
48Atrioventricular block (HP:0001678)3.04727922
49Supraventricular arrhythmia (HP:0005115)3.01655707
50Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.95587583
51Heart block (HP:0012722)2.94427152
52Microvesicular hepatic steatosis (HP:0001414)2.92542833
53Increased intramyocellular lipid droplets (HP:0012240)2.92225595
54Progressive macrocephaly (HP:0004481)2.91990131
55EMG: myopathic abnormalities (HP:0003458)2.89890371
56Increased serum lactate (HP:0002151)2.81820552
57Lethargy (HP:0001254)2.81745495
58Syncope (HP:0001279)2.81415241
59Muscle fiber inclusion bodies (HP:0100299)2.79896069
60Exercise intolerance (HP:0003546)2.76927892
61Generalized aminoaciduria (HP:0002909)2.75466248
62Hyporeflexia of lower limbs (HP:0002600)2.74470150
63Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.72353167
64Neoplasm of the adrenal gland (HP:0100631)2.70421011
65Myotonia (HP:0002486)2.70340011
66Asymmetric septal hypertrophy (HP:0001670)2.69609605
67Abnormality of serum amino acid levels (HP:0003112)2.67930147
68Abnormal atrioventricular conduction (HP:0005150)2.67025921
69Abnormality of glycolysis (HP:0004366)2.65988482
70Increased serum pyruvate (HP:0003542)2.65988482
71Ventricular arrhythmia (HP:0004308)2.63631708
72Subaortic stenosis (HP:0001682)2.60178212
73Abnormality of the left ventricular outflow tract (HP:0011103)2.60178212
74Neoplasm of head and neck (HP:0012288)2.58904432
75Esophageal neoplasm (HP:0100751)2.58904432
76Respiratory failure (HP:0002878)2.57315101
77Muscle stiffness (HP:0003552)2.56856049
78Areflexia of lower limbs (HP:0002522)2.55945108
79Methylmalonic aciduria (HP:0012120)2.55205567
80Gout (HP:0001997)2.54608349
81Prolonged QT interval (HP:0001657)2.52146798
82Ventricular fibrillation (HP:0001663)2.50069470
83Conjunctival hamartoma (HP:0100780)2.48633088
84Proximal tubulopathy (HP:0000114)2.47136771
85Progressive muscle weakness (HP:0003323)2.46704871
86Type I transferrin isoform profile (HP:0003642)2.43576437
87CNS demyelination (HP:0007305)2.41891405
88Increased hepatocellular lipid droplets (HP:0006565)2.41824302
89Nemaline bodies (HP:0003798)2.41235501
90Meningioma (HP:0002858)2.40504463
91Myopathic facies (HP:0002058)2.37302191
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35404345
93Abnormal protein N-linked glycosylation (HP:0012347)2.35404345
94Abnormal protein glycosylation (HP:0012346)2.35404345
95Abnormal glycosylation (HP:0012345)2.35404345
96Ulnar deviation of the wrist (HP:0003049)2.34760700
97Abnormality of vitamin B metabolism (HP:0004340)2.31123684
98Type 1 muscle fiber predominance (HP:0003803)2.29125094
99Metabolic acidosis (HP:0001942)2.28562099
100Lipid accumulation in hepatocytes (HP:0006561)2.26372177
101Increased connective tissue (HP:0009025)2.25661517
102Left ventricular hypertrophy (HP:0001712)2.23544182
103Difficulty running (HP:0009046)2.23297253
104Right ventricular cardiomyopathy (HP:0011663)2.23137047
105Abnormal EKG (HP:0003115)2.19387134
106Cerebral hypomyelination (HP:0006808)2.18585774
107Hypoplasia of the capital femoral epiphysis (HP:0003090)2.18580652
108Neck muscle weakness (HP:0000467)2.18327386
109Distal lower limb muscle weakness (HP:0009053)2.18158824
110Nausea (HP:0002018)2.17999599
111Abnormality of aromatic amino acid family metabolism (HP:0004338)2.15719145
112Renal cortical cysts (HP:0000803)2.13333395
113Abnormality of the vitamin B12 metabolism (HP:0004341)2.06582335
114Athetosis (HP:0002305)2.05097602
115Abnormality of methionine metabolism (HP:0010901)2.04726530
116Distal arthrogryposis (HP:0005684)2.04395357
117Rimmed vacuoles (HP:0003805)2.03585941
118Pancreatic islet-cell hyperplasia (HP:0004510)2.00795187
119Vomiting (HP:0002013)2.00027057
120Methylmalonic acidemia (HP:0002912)1.96075534
121Difficulty climbing stairs (HP:0003551)1.94215797
122Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.89873953
123Facial diplegia (HP:0001349)1.88605219
124Bile duct proliferation (HP:0001408)1.88244735
125Abnormal biliary tract physiology (HP:0012439)1.88244735
126Emotional lability (HP:0000712)1.88157764
127Malignant hyperthermia (HP:0002047)1.87220241
128Squamous cell carcinoma (HP:0002860)1.86345780
129Progressive inability to walk (HP:0002505)1.84551133
130Hyperkalemia (HP:0002153)1.81508455
131Pancreatic fibrosis (HP:0100732)1.80181922
132Opisthotonus (HP:0002179)1.77249266
133Melanoma (HP:0002861)1.76698236
134Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72592710
135Absent epiphyses (HP:0010577)1.72592710
136Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.72236036
1373-Methylglutaconic aciduria (HP:0003535)1.71672239
138Gaze-evoked nystagmus (HP:0000640)1.69098213
139Ependymoma (HP:0002888)1.66813019
140Late onset (HP:0003584)1.66183820
141Medial flaring of the eyebrow (HP:0010747)1.65952036
142Abnormality of vitamin metabolism (HP:0100508)1.65543828

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.52375621
2BCKDK4.92286582
3PDK34.35377458
4PDK44.35377458
5NEK14.23219051
6OBSCN3.68036511
7PHKG23.48440556
8PHKG13.48440556
9LMTK23.28608594
10TTN3.20756925
11PINK13.03205143
12PDK22.56974846
13MYLK2.41604995
14PBK2.40718459
15TRIB32.22394171
16MUSK2.20318514
17VRK22.19713441
18EIF2AK32.07926650
19MAP4K22.00876410
20FLT31.98703121
21ZAK1.83171942
22PKN21.79636107
23TSSK61.79475092
24STK161.77439294
25TIE11.72972667
26STK241.58162396
27BRSK21.51916672
28FGFR21.48419227
29LIMK11.35464544
30BUB11.30654487
31STK38L1.28408319
32NEK21.19007009
33EIF2AK11.17983623
34STK391.09999962
35MAP3K51.09792883
36MAP2K71.09774611
37CCNB11.09523891
38EEF2K1.06913990
39GRK71.06677074
40BRSK10.94786088
41TAOK20.94298575
42NME10.94256594
43MAP2K30.94237126
44PRKAA10.93967049
45MAP2K40.93900347
46OXSR10.93480138
47CDK80.93382163
48TRIM280.93377941
49INSRR0.91553888
50PRKCI0.90585094
51SGK20.90559516
52PIK3CA0.86130312
53NME20.85311196
54MAPK120.85299014
55WEE10.84426818
56MET0.82568398
57WNK30.81448942
58PIK3CG0.81102863
59MST1R0.79992601
60STK40.79925305
61RPS6KB20.78817696
62ATR0.77350517
63AKT30.77075252
64MAP3K120.77053401
65NUAK10.76722299
66MAP2K60.76562104
67BCR0.76291627
68SGK30.76220696
69DMPK0.70981418
70MST40.69160380
71PIM20.68814574
72MAPKAPK30.66969356
73ERBB30.64938230
74NEK90.64800150
75MAPKAPK50.64733592
76CLK10.64288195
77PRKAA20.63333447
78CHEK20.63243516
79CDC70.63146415
80CAMK2D0.62659025
81MAPK130.62582242
82MAPK110.62048742
83EPHA20.58803668
84CSNK1A1L0.58796658
85ATM0.58791107
86MAP3K110.57725174
87RIPK10.56945541
88CSNK1G30.55571421
89BRD40.55422660
90AURKB0.54713296
91AKT20.52393471
92ILK0.50433122
93CHEK10.50047440
94CAMK2G0.49681539
95SRPK10.49581599
96PLK40.47464598
97TTK0.46621660
98EPHA40.46456238
99CSNK1G10.45135165
100SIK20.44627170
101ARAF0.44600261
102SGK4940.44083288
103SGK2230.44083288
104BRAF0.43869281
105PRKACG0.43650480
106DAPK20.42879288
107CAMK40.42207450
108MAP3K70.41644999
109PRKACB0.41451675
110STK380.41149199
111TRPM70.41062724
112CDK120.40424975
113SIK10.39517845
114PLK30.38686197
115VRK10.36938672
116MAP3K40.36273861
117SIK30.36269551
118CAMKK20.35618456
119RPS6KC10.35498522
120RPS6KL10.35498522
121PRKD30.34224254
122PLK20.33569704
123CSNK1A10.33420689
124PRKACA0.32422797
125CDK10.32028859
126ROCK10.31768438
127DAPK10.31686346
128BMPR1B0.30442728
129PAK30.30398947
130MAP2K10.29781312
131ADRBK10.28782346
132MAP3K30.28476435
133PRKD10.27940898
134ACVR1B0.27612231
135PLK10.26969572
136RPS6KA60.26039811
137CAMK10.24897831
138PRKCG0.24759698
139WNK40.24145651
140DAPK30.23338073
141CAMK2A0.23248964
142RPS6KB10.23223250
143LATS20.20994242
144PRKCE0.19329465
145LRRK20.19250492
146CDC42BPA0.19006748
147PDK10.17947064

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.87243872
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.51001694
3Propanoate metabolism_Homo sapiens_hsa006403.71361204
4Fatty acid degradation_Homo sapiens_hsa000713.25895819
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.10773411
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.02953616
7Carbon metabolism_Homo sapiens_hsa012002.85789966
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.81805013
9Fatty acid metabolism_Homo sapiens_hsa012122.73266176
10Oxidative phosphorylation_Homo sapiens_hsa001902.35919962
11Pyruvate metabolism_Homo sapiens_hsa006202.35034574
12Parkinsons disease_Homo sapiens_hsa050122.31821656
13Non-homologous end-joining_Homo sapiens_hsa034502.02946668
14Butanoate metabolism_Homo sapiens_hsa006501.98447792
15Biosynthesis of amino acids_Homo sapiens_hsa012301.96619632
16Cardiac muscle contraction_Homo sapiens_hsa042601.94914121
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.58170879
18Homologous recombination_Homo sapiens_hsa034401.57680828
19beta-Alanine metabolism_Homo sapiens_hsa004101.57363930
20Fanconi anemia pathway_Homo sapiens_hsa034601.57287437
21Peroxisome_Homo sapiens_hsa041461.54756694
22Fatty acid elongation_Homo sapiens_hsa000621.51680071
23Mismatch repair_Homo sapiens_hsa034301.48678723
24Vitamin B6 metabolism_Homo sapiens_hsa007501.46780350
25PPAR signaling pathway_Homo sapiens_hsa033201.46123853
26Tryptophan metabolism_Homo sapiens_hsa003801.44279344
27Huntingtons disease_Homo sapiens_hsa050161.44207888
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43107145
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.42623866
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41250049
31Alzheimers disease_Homo sapiens_hsa050101.41039670
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38320129
33Fructose and mannose metabolism_Homo sapiens_hsa000511.38131755
34Nucleotide excision repair_Homo sapiens_hsa034201.37317421
35Arginine biosynthesis_Homo sapiens_hsa002201.34683008
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30774951
37Fatty acid biosynthesis_Homo sapiens_hsa000611.27768636
38RNA degradation_Homo sapiens_hsa030181.26085314
39Proteasome_Homo sapiens_hsa030501.25507190
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22670879
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21966675
42Starch and sucrose metabolism_Homo sapiens_hsa005001.21682168
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19122914
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17569959
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16644700
46Protein export_Homo sapiens_hsa030601.16164740
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.11092683
48Phenylalanine metabolism_Homo sapiens_hsa003601.10060054
49N-Glycan biosynthesis_Homo sapiens_hsa005101.08998084
50Dilated cardiomyopathy_Homo sapiens_hsa054141.08037134
51Pentose phosphate pathway_Homo sapiens_hsa000301.07740982
52Arginine and proline metabolism_Homo sapiens_hsa003301.02046635
53Folate biosynthesis_Homo sapiens_hsa007900.98676322
54Sulfur relay system_Homo sapiens_hsa041220.97785400
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97703192
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97065223
57Galactose metabolism_Homo sapiens_hsa000520.90161748
58RNA polymerase_Homo sapiens_hsa030200.87103925
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.84551365
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83792861
61Glucagon signaling pathway_Homo sapiens_hsa049220.81030291
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79970135
63Basal transcription factors_Homo sapiens_hsa030220.79629361
64Metabolic pathways_Homo sapiens_hsa011000.78612900
65Selenocompound metabolism_Homo sapiens_hsa004500.78325138
66Spliceosome_Homo sapiens_hsa030400.72110087
67Regulation of autophagy_Homo sapiens_hsa041400.69553031
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67669687
69Tyrosine metabolism_Homo sapiens_hsa003500.67621659
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.67359541
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67192938
72Steroid biosynthesis_Homo sapiens_hsa001000.67048703
73One carbon pool by folate_Homo sapiens_hsa006700.66473209
74Pyrimidine metabolism_Homo sapiens_hsa002400.65995720
75Oocyte meiosis_Homo sapiens_hsa041140.65389452
76Insulin signaling pathway_Homo sapiens_hsa049100.60293603
77mRNA surveillance pathway_Homo sapiens_hsa030150.60004948
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59345012
79Cell cycle_Homo sapiens_hsa041100.58156746
80Purine metabolism_Homo sapiens_hsa002300.58126458
81Glycerolipid metabolism_Homo sapiens_hsa005610.56158596
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55658881
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52445770
84Circadian rhythm_Homo sapiens_hsa047100.51136471
85Insulin resistance_Homo sapiens_hsa049310.51011085
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50843919
87Vitamin digestion and absorption_Homo sapiens_hsa049770.49500965
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48920153
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48173955
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47272493
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45296303
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43697607
93Nitrogen metabolism_Homo sapiens_hsa009100.39272718
94AMPK signaling pathway_Homo sapiens_hsa041520.39151344
95Fat digestion and absorption_Homo sapiens_hsa049750.38410687
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.36768755
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36599284
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.34842916
99Sulfur metabolism_Homo sapiens_hsa009200.32527834
100Ether lipid metabolism_Homo sapiens_hsa005650.32440641
101Base excision repair_Homo sapiens_hsa034100.32006152
102DNA replication_Homo sapiens_hsa030300.31287261
103Glutathione metabolism_Homo sapiens_hsa004800.29915027
104Lysine degradation_Homo sapiens_hsa003100.29914314
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29277774
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27978897
107Collecting duct acid secretion_Homo sapiens_hsa049660.26724300
108Bile secretion_Homo sapiens_hsa049760.25690616
109Histidine metabolism_Homo sapiens_hsa003400.23546474
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22634668
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22592114
112ABC transporters_Homo sapiens_hsa020100.19713567
113Chemical carcinogenesis_Homo sapiens_hsa052040.19255524
114Retinol metabolism_Homo sapiens_hsa008300.18671432
115Calcium signaling pathway_Homo sapiens_hsa040200.16661098
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.16403696
117RNA transport_Homo sapiens_hsa030130.15333773
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.14684758
119Synaptic vesicle cycle_Homo sapiens_hsa047210.13655802
120Caffeine metabolism_Homo sapiens_hsa002320.10517129
121Insulin secretion_Homo sapiens_hsa049110.09229611
122HIF-1 signaling pathway_Homo sapiens_hsa040660.09070985

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