UQCC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nucleoid protein localized to the mitochondria inner membrane. The encoded protein affects regulation of insulin secretion, mitochondrial ATP production, and myogenesis through modulation of mitochondrial respiratory chain activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.15376351
2energy coupled proton transport, down electrochemical gradient (GO:0015985)7.83922463
3ATP synthesis coupled proton transport (GO:0015986)7.83922463
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.47599896
5respiratory electron transport chain (GO:0022904)6.72059000
6electron transport chain (GO:0022900)6.59303024
7ribosomal small subunit assembly (GO:0000028)5.70182528
8viral transcription (GO:0019083)5.63414305
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.52287745
10cotranslational protein targeting to membrane (GO:0006613)5.46276057
11protein targeting to ER (GO:0045047)5.43712114
12translational termination (GO:0006415)5.43460477
13ribosomal small subunit biogenesis (GO:0042274)5.34855055
14establishment of protein localization to endoplasmic reticulum (GO:0072599)5.17786755
15protein localization to endoplasmic reticulum (GO:0070972)5.13483607
16* protein complex biogenesis (GO:0070271)4.89028312
17translational elongation (GO:0006414)4.71928962
18chaperone-mediated protein transport (GO:0072321)4.53260593
19establishment of protein localization to mitochondrial membrane (GO:0090151)4.51382063
20* mitochondrial respiratory chain complex assembly (GO:0033108)4.49892403
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.43910530
22NADH dehydrogenase complex assembly (GO:0010257)4.43910530
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.43910530
24ATP biosynthetic process (GO:0006754)4.42875706
25cellular protein complex disassembly (GO:0043624)4.42415235
26maturation of SSU-rRNA (GO:0030490)4.41204142
27purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.39666213
28protein neddylation (GO:0045116)4.38708755
29translation (GO:0006412)4.36432347
30hydrogen ion transmembrane transport (GO:1902600)4.34972216
31viral life cycle (GO:0019058)4.31858323
32purine nucleoside triphosphate biosynthetic process (GO:0009145)4.29807964
33GTP biosynthetic process (GO:0006183)4.28432990
34inner mitochondrial membrane organization (GO:0007007)4.12848444
35oxidative phosphorylation (GO:0006119)4.12066447
36ribosomal large subunit biogenesis (GO:0042273)4.11963982
37translational initiation (GO:0006413)4.09691368
38rRNA modification (GO:0000154)4.05527677
39cullin deneddylation (GO:0010388)3.97144767
40ribonucleoside triphosphate biosynthetic process (GO:0009201)3.92554469
41nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.90426232
42UTP biosynthetic process (GO:0006228)3.75166929
43guanosine-containing compound biosynthetic process (GO:1901070)3.73656398
44protein complex disassembly (GO:0043241)3.73243888
45proton transport (GO:0015992)3.69039608
46macromolecular complex disassembly (GO:0032984)3.65703822
47protein targeting to membrane (GO:0006612)3.62934967
48DNA deamination (GO:0045006)3.61338986
49hydrogen transport (GO:0006818)3.58439373
50protein deneddylation (GO:0000338)3.55152535
51formation of translation preinitiation complex (GO:0001731)3.55021851
52chromatin remodeling at centromere (GO:0031055)3.54211680
53respiratory chain complex IV assembly (GO:0008535)3.52403692
54pseudouridine synthesis (GO:0001522)3.51542784
55protein targeting to mitochondrion (GO:0006626)3.49992695
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.49119837
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.48717970
58CENP-A containing nucleosome assembly (GO:0034080)3.47128254
59RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.46554593
60tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.46554593
61nucleoside triphosphate biosynthetic process (GO:0009142)3.44851564
62water-soluble vitamin biosynthetic process (GO:0042364)3.41088208
63regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.41032715
64establishment of protein localization to mitochondrion (GO:0072655)3.40886692
65proteasome assembly (GO:0043248)3.37105395
66energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.35770418
67ATP hydrolysis coupled proton transport (GO:0015991)3.35770418
68kinetochore assembly (GO:0051382)3.34990798
69* cytochrome complex assembly (GO:0017004)3.34415654
70deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.33121490
71establishment of integrated proviral latency (GO:0075713)3.32843920
72intracellular protein transmembrane import (GO:0044743)3.27750036
73sequestering of actin monomers (GO:0042989)3.26956895
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.25982976
75spliceosomal snRNP assembly (GO:0000387)3.25649263
76rRNA methylation (GO:0031167)3.25628917
77DNA double-strand break processing (GO:0000729)3.24247279
78cellular copper ion homeostasis (GO:0006878)3.22834865
79* regulation of oxidative phosphorylation (GO:0002082)3.22723885
80peptidyl-histidine modification (GO:0018202)3.22379474
81protein localization to mitochondrion (GO:0070585)3.22252876
82termination of RNA polymerase III transcription (GO:0006386)3.20865298
83transcription elongation from RNA polymerase III promoter (GO:0006385)3.20865298
84protein maturation by protein folding (GO:0022417)3.20132869
85kinetochore organization (GO:0051383)3.17202111
86DNA replication checkpoint (GO:0000076)3.16691067
87ribonucleoprotein complex biogenesis (GO:0022613)3.12735927
88negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.12447904
89UTP metabolic process (GO:0046051)3.09915405
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08348801
91rRNA processing (GO:0006364)3.07674826
927-methylguanosine mRNA capping (GO:0006370)3.07191486
93nucleoside diphosphate phosphorylation (GO:0006165)3.06271738
94CTP metabolic process (GO:0046036)3.06040531
95CTP biosynthetic process (GO:0006241)3.06040531
96DNA damage response, detection of DNA damage (GO:0042769)3.05432297
97nuclear-transcribed mRNA catabolic process (GO:0000956)3.05094643
98regulation of cellular amino acid metabolic process (GO:0006521)3.04699512
99pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.98875923
100telomere maintenance via semi-conservative replication (GO:0032201)2.98409009
101heart contraction (GO:0060047)2.98221129
102heart process (GO:0003015)2.98221129
103positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97450705
104RNA capping (GO:0036260)2.96443579
1057-methylguanosine RNA capping (GO:0009452)2.96443579
106aerobic respiration (GO:0009060)2.95917676
107signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.95697608
108signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.95697608
109signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.95697608
110* regulation of mitochondrial translation (GO:0070129)2.95455476
111rRNA metabolic process (GO:0016072)2.95311254
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.94783591
113protein localization to cilium (GO:0061512)2.93923086
114protein-cofactor linkage (GO:0018065)2.92778611
115intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92389904
116signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92389904
117establishment of viral latency (GO:0019043)2.90274381
118negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87125595
119negative regulation of ligase activity (GO:0051352)2.87125595
120mitochondrial transport (GO:0006839)2.85499190
121* cellular component biogenesis (GO:0044085)2.84906464
122purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.82576358
123purine nucleoside monophosphate biosynthetic process (GO:0009127)2.82576358
124establishment of protein localization to membrane (GO:0090150)2.81081327
125DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.78930995
126positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.78663354
127copper ion homeostasis (GO:0055070)2.75903815
128GDP-mannose metabolic process (GO:0019673)2.75421331
129pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.75138250
130protein targeting (GO:0006605)2.74540668
131regulation of cilium movement (GO:0003352)2.71514697
132antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.70977718

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.50578562
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.17499954
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.03411655
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.91490653
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.58846478
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.50461027
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32551693
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.15853260
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.12507842
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.08410258
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.08209871
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05047586
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94798884
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.87968127
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.77480339
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.70176327
17EZH2_22144423_ChIP-Seq_EOC_Human2.67233167
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65297443
19E2F7_22180533_ChIP-Seq_HELA_Human2.60489500
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54221193
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41071427
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34686185
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30920599
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.30465907
25CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.26137713
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.10526648
27VDR_22108803_ChIP-Seq_LS180_Human2.10222757
28VDR_23849224_ChIP-Seq_CD4+_Human2.07656631
29YY1_21170310_ChIP-Seq_MESCs_Mouse2.04291605
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01732231
31MYC_19079543_ChIP-ChIP_MESCs_Mouse2.00981459
32ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.98657640
33DCP1A_22483619_ChIP-Seq_HELA_Human1.97078778
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.94700611
35XRN2_22483619_ChIP-Seq_HELA_Human1.92283184
36ZNF274_21170338_ChIP-Seq_K562_Hela1.82574098
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81600686
38TTF2_22483619_ChIP-Seq_HELA_Human1.79900328
39FOXP3_21729870_ChIP-Seq_TREG_Human1.77995495
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70701401
41CTCF_18555785_ChIP-Seq_MESCs_Mouse1.68764886
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67848535
43ELK1_19687146_ChIP-ChIP_HELA_Human1.64952426
44GABP_19822575_ChIP-Seq_HepG2_Human1.60936212
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51584300
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51447059
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48933564
48BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.46264812
49ELK1_22589737_ChIP-Seq_MCF10A_Human1.45641663
50SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.44482288
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.43597002
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41495158
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38269956
54IGF1R_20145208_ChIP-Seq_DFB_Human1.37483084
55SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31330834
56KDM5A_27292631_Chip-Seq_BREAST_Human1.31298268
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31260043
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28801672
59YY1_22570637_ChIP-Seq_MALME-3M_Human1.28683112
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28507879
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25351255
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.24493433
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22488367
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17722787
65MYC_18940864_ChIP-ChIP_HL60_Human1.17284240
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16820983
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15852966
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15485873
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07856306
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06990323
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05990233
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05844167
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04928691
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04774224
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04662281
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04514425
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03957554
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.01709070
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01670801
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00255084
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99328803
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97259558
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94337294
84EWS_26573619_Chip-Seq_HEK293_Human0.94029331
85TET1_21451524_ChIP-Seq_MESCs_Mouse0.92215055
86POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91774198
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91156797
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87817809
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87313354
90TP53_22573176_ChIP-Seq_HFKS_Human0.85717141
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.84005962
92AR_21909140_ChIP-Seq_LNCAP_Human0.83564669
93FUS_26573619_Chip-Seq_HEK293_Human0.82752525
94SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82553622
95EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.82321811
96HTT_18923047_ChIP-ChIP_STHdh_Human0.82222063
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81980452
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81057290
99REST_19997604_ChIP-ChIP_NEURONS_Mouse0.80268718
100MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79623931
101FOXP1_21924763_ChIP-Seq_HESCs_Human0.79209200
102ETV2_25802403_ChIP-Seq_MESCs_Mouse0.78744844
103ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77977858
104ERG_20517297_ChIP-Seq_VCAP_Human0.75359646
105PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.75344270
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.74761608
107CTBP2_25329375_ChIP-Seq_LNCAP_Human0.74490325
108CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.73464130
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.71938998
110MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.71825778
111CIITA_25753668_ChIP-Seq_RAJI_Human0.71288563
112NANOG_18555785_ChIP-Seq_MESCs_Mouse0.71277872
113CTCF_26484167_Chip-Seq_Bcells_Mouse0.70404608
114NANOG_20526341_ChIP-Seq_ESCs_Human0.70108832
115MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.69937973
116STAT1_20625510_ChIP-Seq_HELA_Human0.69797414
117SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.69533052
118REST_18959480_ChIP-ChIP_MESCs_Mouse0.69416058
119EZH2_27304074_Chip-Seq_ESCs_Mouse0.69318197
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.69093105
121RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.69051417
122TBX5_21415370_ChIP-Seq_HL-1_Mouse0.67662036
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.67171559
124SOX2_18692474_ChIP-Seq_MEFs_Mouse0.66332128
125NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.66149607
126ELF5_23300383_ChIP-Seq_T47D_Human0.63333341
127AR_20517297_ChIP-Seq_VCAP_Human0.62198635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.85003086
2MP0009379_abnormal_foot_pigmentation3.77608394
3MP0008058_abnormal_DNA_repair2.87342353
4MP0000749_muscle_degeneration2.82386858
5MP0001529_abnormal_vocalization2.74501456
6MP0003806_abnormal_nucleotide_metabolis2.67685374
7MP0000751_myopathy2.52279010
8MP0003880_abnormal_central_pattern2.51185534
9MP0006276_abnormal_autonomic_nervous2.51066087
10MP0006036_abnormal_mitochondrial_physio2.45752054
11MP0003186_abnormal_redox_activity2.41851713
12MP0003693_abnormal_embryo_hatching2.40685900
13MP0010094_abnormal_chromosome_stability2.31780910
14MP0005410_abnormal_fertilization2.31585094
15MP0005408_hypopigmentation2.28905278
16MP0004957_abnormal_blastocyst_morpholog2.25970949
17MP0003136_yellow_coat_color2.23713702
18MP0003646_muscle_fatigue2.23120897
19MP0006072_abnormal_retinal_apoptosis2.22322560
20MP0004145_abnormal_muscle_electrophysio2.09010312
21MP0002277_abnormal_respiratory_mucosa2.05963014
22MP0003718_maternal_effect1.96973659
23MP0003122_maternal_imprinting1.96176630
24MP0002638_abnormal_pupillary_reflex1.95582173
25MP0000372_irregular_coat_pigmentation1.94849021
26MP0010386_abnormal_urinary_bladder1.89877243
27MP0003111_abnormal_nucleus_morphology1.89420026
28MP0003786_premature_aging1.88005417
29MP0006035_abnormal_mitochondrial_morpho1.86904665
30MP0004036_abnormal_muscle_relaxation1.85592604
31MP0001905_abnormal_dopamine_level1.82631125
32MP0003283_abnormal_digestive_organ1.80654979
33MP0000013_abnormal_adipose_tissue1.76432059
34MP0004215_abnormal_myocardial_fiber1.69425085
35MP0003077_abnormal_cell_cycle1.65516824
36MP0004084_abnormal_cardiac_muscle1.64711971
37MP0002751_abnormal_autonomic_nervous1.62536295
38MP0005084_abnormal_gallbladder_morpholo1.62297058
39MP0005171_absent_coat_pigmentation1.58079987
40MP0002102_abnormal_ear_morphology1.55676860
41MP0005379_endocrine/exocrine_gland_phen1.53238444
42MP0001293_anophthalmia1.52461718
43MP0008789_abnormal_olfactory_epithelium1.52166263
44MP0004142_abnormal_muscle_tone1.51354270
45MP0004043_abnormal_pH_regulation1.50524967
46MP0006292_abnormal_olfactory_placode1.50406769
47MP0001188_hyperpigmentation1.50245813
48MP0004272_abnormal_basement_membrane1.47013727
49MP0003137_abnormal_impulse_conducting1.44973897
50MP0002909_abnormal_adrenal_gland1.43155287
51MP0002163_abnormal_gland_morphology1.42050178
52MP0008995_early_reproductive_senescence1.41070178
53MP0004147_increased_porphyrin_level1.41036507
54MP0003011_delayed_dark_adaptation1.39640728
55MP0002693_abnormal_pancreas_physiology1.39423310
56MP0002736_abnormal_nociception_after1.38701448
57MP0000750_abnormal_muscle_regeneration1.36455687
58MP0009697_abnormal_copulation1.36126498
59MP0000678_abnormal_parathyroid_gland1.35395576
60MP0005503_abnormal_tendon_morphology1.34370614
61MP0001986_abnormal_taste_sensitivity1.34150292
62MP0008007_abnormal_cellular_replicative1.29710118
63MP0001968_abnormal_touch/_nociception1.29582847
64MP0002653_abnormal_ependyma_morphology1.28123256
65MP0002272_abnormal_nervous_system1.26921409
66MP0005330_cardiomyopathy1.26308973
67MP0002734_abnormal_mechanical_nocicepti1.24133973
68MP0005394_taste/olfaction_phenotype1.23644544
69MP0005499_abnormal_olfactory_system1.23644544
70MP0005332_abnormal_amino_acid1.22915072
71MP0002106_abnormal_muscle_physiology1.22076745
72MP0001485_abnormal_pinna_reflex1.20895702
73MP0003121_genomic_imprinting1.20683900
74MP0003123_paternal_imprinting1.19457776
75MP0004270_analgesia1.19099300
76MP0002876_abnormal_thyroid_physiology1.18933874
77MP0005646_abnormal_pituitary_gland1.16174004
78MP0005369_muscle_phenotype1.13268971
79MP0001764_abnormal_homeostasis1.13202252
80MP0005551_abnormal_eye_electrophysiolog1.11266445
81MP0002210_abnormal_sex_determination1.09579580
82MP0000759_abnormal_skeletal_muscle1.09370483
83MP0003635_abnormal_synaptic_transmissio1.05986353
84MP0002160_abnormal_reproductive_system1.05883092
85MP0002735_abnormal_chemical_nociception1.05780811
86MP0001944_abnormal_pancreas_morphology1.05434777
87MP0000358_abnormal_cell_content/1.05107867
88MP0000049_abnormal_middle_ear1.04330391
89MP0009745_abnormal_behavioral_response1.03803671
90MP0008932_abnormal_embryonic_tissue1.03023792
91MP0004133_heterotaxia1.02899432
92MP0001970_abnormal_pain_threshold1.02578687
93MP0002572_abnormal_emotion/affect_behav1.02047717
94MP0002733_abnormal_thermal_nociception1.00238550
95MP0001984_abnormal_olfaction0.99281960
96MP0005636_abnormal_mineral_homeostasis0.99158126
97MP0002234_abnormal_pharynx_morphology0.99077520
98MP0003941_abnormal_skin_development0.98954031
99MP0005620_abnormal_muscle_contractility0.98924784
100MP0000747_muscle_weakness0.98260366
101MP0002938_white_spotting0.95238408
102MP0002972_abnormal_cardiac_muscle0.95095939
103MP0000631_abnormal_neuroendocrine_gland0.94555333
104MP0003938_abnormal_ear_development0.94360942
105MP0005389_reproductive_system_phenotype0.93962227
106MP0009046_muscle_twitch0.93006888
107MP0004085_abnormal_heartbeat0.92698360
108MP0002184_abnormal_innervation0.92637783
109MP0004019_abnormal_vitamin_homeostasis0.91207224
110MP0002064_seizures0.91051791
111MP0001186_pigmentation_phenotype0.90056957
112MP0000653_abnormal_sex_gland0.89184509
113MP0001145_abnormal_male_reproductive0.88991940
114MP0002090_abnormal_vision0.88232382
115MP0008875_abnormal_xenobiotic_pharmacok0.88087739
116MP0008877_abnormal_DNA_methylation0.88022499
117MP0005253_abnormal_eye_physiology0.86908351
118MP0003698_abnormal_male_reproductive0.86673947
119MP0002067_abnormal_sensory_capabilities0.86140106
120MP0003567_abnormal_fetal_cardiomyocyte0.85837995
121MP0002095_abnormal_skin_pigmentation0.85640261
122MP0005645_abnormal_hypothalamus_physiol0.84967614
123MP0008872_abnormal_physiological_respon0.84720432
124MP0002269_muscular_atrophy0.84064090
125MP0003937_abnormal_limbs/digits/tail_de0.83709068
126MP0003787_abnormal_imprinting0.83051757
127MP0002877_abnormal_melanocyte_morpholog0.82279103
128MP0005174_abnormal_tail_pigmentation0.81384445
129MP0002557_abnormal_social/conspecific_i0.79269480
130MP0002063_abnormal_learning/memory/cond0.78326036
131MP0001929_abnormal_gametogenesis0.78271786
132MP0002822_catalepsy0.77997427
133MP0001919_abnormal_reproductive_system0.77967186
134MP0005386_behavior/neurological_phenoty0.77014123
135MP0004924_abnormal_behavior0.77014123
136MP0003879_abnormal_hair_cell0.74109569
137MP0010030_abnormal_orbit_morphology0.73692279
138MP0003315_abnormal_perineum_morphology0.73464975
139MP0003195_calcinosis0.73285163
140MP0002127_abnormal_cardiovascular_syste0.72569374
141MP0004859_abnormal_synaptic_plasticity0.72472286
142MP0002233_abnormal_nose_morphology0.66818425

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.97965884
2Abnormal mitochondria in muscle tissue (HP:0008316)7.29206783
3Progressive macrocephaly (HP:0004481)6.56826567
4Mitochondrial inheritance (HP:0001427)6.51268792
5Acute encephalopathy (HP:0006846)6.30922828
6Increased CSF lactate (HP:0002490)5.45320903
7Hepatocellular necrosis (HP:0001404)5.36557104
8Hepatic necrosis (HP:0002605)4.82943978
9Abnormality of cells of the erythroid lineage (HP:0012130)4.52935579
10Increased hepatocellular lipid droplets (HP:0006565)4.45557615
11Exercise intolerance (HP:0003546)4.43896171
12Optic disc pallor (HP:0000543)4.18839901
13Cerebral edema (HP:0002181)4.16481418
14Lipid accumulation in hepatocytes (HP:0006561)4.07534098
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.96943734
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.96943734
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.94150291
18Abnormal number of erythroid precursors (HP:0012131)3.92125005
19Respiratory failure (HP:0002878)3.74870287
20Increased intramyocellular lipid droplets (HP:0012240)3.59914690
21Renal Fanconi syndrome (HP:0001994)3.49826918
22Lactic acidosis (HP:0003128)3.48335202
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.45899874
24Leukodystrophy (HP:0002415)3.31704365
25Neuroendocrine neoplasm (HP:0100634)3.29034097
26Exertional dyspnea (HP:0002875)3.18118136
27Increased serum lactate (HP:0002151)3.17023114
28Pheochromocytoma (HP:0002666)3.16095784
29Increased muscle lipid content (HP:0009058)3.10294771
30Reticulocytopenia (HP:0001896)2.85191185
313-Methylglutaconic aciduria (HP:0003535)2.80867832
32Hypothermia (HP:0002045)2.80463007
33Aplastic anemia (HP:0001915)2.74334519
34Macrocytic anemia (HP:0001972)2.72087457
35Colon cancer (HP:0003003)2.64092378
36Methylmalonic acidemia (HP:0002912)2.59723210
37Respiratory difficulties (HP:0002880)2.56743040
38Muscle hypertrophy of the lower extremities (HP:0008968)2.56563649
39Sudden death (HP:0001699)2.48385264
40Calf muscle hypertrophy (HP:0008981)2.46527416
41Methylmalonic aciduria (HP:0012120)2.46345505
42Medial flaring of the eyebrow (HP:0010747)2.41800874
43Palpitations (HP:0001962)2.41268093
44Pallor (HP:0000980)2.39430760
45Emotional lability (HP:0000712)2.37773782
46Exercise-induced myalgia (HP:0003738)2.36344525
47Abnormality of renal resorption (HP:0011038)2.34746344
48Septo-optic dysplasia (HP:0100842)2.34071945
49Microvesicular hepatic steatosis (HP:0001414)2.33287839
50Myotonia (HP:0002486)2.31930247
51Nephrogenic diabetes insipidus (HP:0009806)2.25525972
52Myoglobinuria (HP:0002913)2.24458059
53X-linked dominant inheritance (HP:0001423)2.24361609
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24212622
55Exercise-induced muscle cramps (HP:0003710)2.22067987
56Hyperphosphaturia (HP:0003109)2.21686374
57Progressive external ophthalmoplegia (HP:0000590)2.21537565
58Type I transferrin isoform profile (HP:0003642)2.19969654
59Absent thumb (HP:0009777)2.19857527
60Congenital, generalized hypertrichosis (HP:0004540)2.13294749
61Hyperglycinemia (HP:0002154)2.11204704
62Progressive muscle weakness (HP:0003323)2.10064364
63Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.09518884
64Abnormality of the labia minora (HP:0012880)2.09127208
65Increased serum pyruvate (HP:0003542)2.05905449
66Abnormality of glycolysis (HP:0004366)2.05905449
67Congenital primary aphakia (HP:0007707)2.05275079
68Rimmed vacuoles (HP:0003805)2.04820310
69Dynein arm defect of respiratory motile cilia (HP:0012255)2.03895629
70Absent/shortened dynein arms (HP:0200106)2.03895629
71Meckel diverticulum (HP:0002245)2.03383163
72Myokymia (HP:0002411)2.03022919
73Abnormality of midbrain morphology (HP:0002418)2.02198897
74Molar tooth sign on MRI (HP:0002419)2.02198897
75Cerebral hypomyelination (HP:0006808)2.01751299
76Gait imbalance (HP:0002141)2.01643928
77Conjunctival hamartoma (HP:0100780)2.00975663
78Degeneration of anterior horn cells (HP:0002398)2.00138788
79Abnormality of the anterior horn cell (HP:0006802)2.00138788
80Sclerocornea (HP:0000647)1.96186114
81Abnormality of methionine metabolism (HP:0010901)1.94698640
82CNS demyelination (HP:0007305)1.91187366
83Abnormality of aromatic amino acid family metabolism (HP:0004338)1.90874802
84Hypoglycemic coma (HP:0001325)1.90484735
85Pancytopenia (HP:0001876)1.90418532
86Abnormality of the ileum (HP:0001549)1.90402179
87Nephronophthisis (HP:0000090)1.87860837
88Generalized aminoaciduria (HP:0002909)1.86451969
89Glycosuria (HP:0003076)1.83941652
90Abnormality of urine glucose concentration (HP:0011016)1.83941652
91Rhabdomyolysis (HP:0003201)1.83903276
92Oral leukoplakia (HP:0002745)1.83608108
93Dicarboxylic aciduria (HP:0003215)1.83117530
94Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83117530
95Testicular atrophy (HP:0000029)1.82007606
96True hermaphroditism (HP:0010459)1.79646834
97Poor suck (HP:0002033)1.78879186
98Abnormal respiratory epithelium morphology (HP:0012253)1.78717807
99Abnormal respiratory motile cilium morphology (HP:0005938)1.78717807
100Neoplasm of the peripheral nervous system (HP:0100007)1.78710995
101Aplasia/Hypoplasia of the uvula (HP:0010293)1.77356241
102Chromsome breakage (HP:0040012)1.77143536
103Muscle stiffness (HP:0003552)1.76237848
104Ventricular tachycardia (HP:0004756)1.75115672
105Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74726498
106Amniotic constriction ring (HP:0009775)1.74557029
107Abnormality of placental membranes (HP:0011409)1.74557029
108Hyperinsulinemic hypoglycemia (HP:0000825)1.72318631
109Abnormal urine phosphate concentration (HP:0012599)1.71520194
110Maternal diabetes (HP:0009800)1.70982443
111Abnormality of the calf musculature (HP:0001430)1.70928325
112Abnormality of serum amino acid levels (HP:0003112)1.70893018
113Abnormality of the preputium (HP:0100587)1.70314647
114Aplasia/hypoplasia of the uterus (HP:0008684)1.68542551
115Muscle fiber inclusion bodies (HP:0100299)1.68454791
116Pancreatic fibrosis (HP:0100732)1.68213751
117Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67781190
118Blindness (HP:0000618)1.66129477
119Cleft eyelid (HP:0000625)1.66035975
120Rib fusion (HP:0000902)1.65697207
121Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.65379834
122Megaloblastic anemia (HP:0001889)1.65304112
123Left ventricular hypertrophy (HP:0001712)1.64863842
124Triphalangeal thumb (HP:0001199)1.64292661
125Pancreatic cysts (HP:0001737)1.63096133
126Absent septum pellucidum (HP:0001331)1.62028233
127Abnormal pupillary function (HP:0007686)1.62005788
128Limb dystonia (HP:0002451)1.60649093
129Respiratory insufficiency due to muscle weakness (HP:0002747)1.58907999
130Nemaline bodies (HP:0003798)1.58493524
131Delusions (HP:0000746)1.57681309
132Unsteady gait (HP:0002317)1.56869288
133Lethargy (HP:0001254)1.56273727
134EMG: myopathic abnormalities (HP:0003458)1.55880158
135Abnormal hemoglobin (HP:0011902)1.55794785
136Abnormal protein glycosylation (HP:0012346)1.55479300
137Abnormal glycosylation (HP:0012345)1.55479300
138Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.55479300
139Abnormal protein N-linked glycosylation (HP:0012347)1.55479300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK199.64193620
2VRK25.57387057
3TLK14.19352070
4NME22.98641490
5NME12.64903597
6STK162.34621710
7MAP3K102.24446294
8TAF12.13246740
9TESK12.08483220
10MAP3K122.06098542
11NUAK12.05191200
12ARAF1.92755084
13CASK1.88382930
14MAP4K21.84579679
15NEK11.77116694
16MYLK1.74103693
17VRK11.64158298
18OBSCN1.62331738
19PDK41.56343751
20PDK31.56343751
21TTK1.53950088
22LIMK11.51144808
23BRAF1.42551718
24PIM21.42500404
25BUB11.40152651
26GRK71.38579680
27WNK41.32236792
28PLK11.31945159
29EPHB21.31276513
30PHKG21.23226731
31PHKG11.23226731
32WEE11.21989693
33NTRK31.15274937
34CSNK1G31.11869349
35PASK1.10395759
36MAP3K111.09488357
37ILK1.08617363
38BMPR1B1.04574443
39GRK11.03975301
40AURKB1.03645292
41CHEK21.02291939
42CSNK1G11.00514463
43MUSK1.00017242
44EIF2AK10.98539059
45EIF2AK30.96875107
46CSNK1G20.96811613
47GRK50.96306473
48SRPK10.95523693
49BMPR20.95017574
50FRK0.90323934
51MAP2K60.89748273
52DAPK30.85942936
53UHMK10.83391258
54PLK40.81413268
55ATR0.79735413
56ADRBK20.78438492
57CDK11A0.76401970
58MAPK130.75793860
59CSNK1A1L0.74079941
60WNK30.73980828
61MKNK20.73192722
62MAP3K40.72782574
63TRIM280.72627203
64DYRK30.72115987
65BCR0.71988441
66PDK20.71528697
67MAP2K30.71067466
68BCKDK0.71014936
69TSSK60.70559269
70PRKD30.70401745
71PLK20.69461344
72AURKA0.68087663
73IRAK10.67322051
74ABL20.66690481
75STK40.65321578
76BRSK10.65099580
77BRSK20.63197348
78INSRR0.63019229
79PINK10.60493116
80CAMKK20.60238743
81PIK3CG0.59073388
82CDK80.58491654
83RPS6KA50.58202552
84MAPK150.58112039
85ADRBK10.58048025
86MAP2K70.56402496
87PNCK0.56249577
88CAMK2D0.54079420
89MAP2K40.53938322
90EPHA40.53200267
91MAPKAPK50.52066151
92PAK30.52054353
93TTN0.51624517
94EIF2AK20.51160182
95CCNB10.50745743
96ERBB30.49523580
97CSNK1E0.49017008
98CDC42BPA0.48813741
99OXSR10.47645400
100NEK20.47419485
101ZAK0.47043241
102ATM0.46066305
103TESK20.44453647
104CAMK2A0.44289031
105CHEK10.43689889
106PRKCG0.43123382
107DYRK20.41909318
108FGFR20.41001416
109MKNK10.40709263
110CSNK1A10.40535694
111CSNK2A10.40270624
112CAMK2B0.40067413
113CSNK2A20.39881228
114KDR0.39834085
115PLK30.38510491
116PRKACA0.38188673
117STK390.37905213
118CDK140.37885483
119DAPK10.36732901
120MST40.36404796
121CDK70.35515518
122LRRK20.35424046
123MAPK120.34893719
124PRKCI0.34860490
125PBK0.34253316
126CDC70.34025643
127TNIK0.33800529
128PTK2B0.33766619
129CDK180.33526135
130MAPKAPK30.32898320
131MINK10.32625040
132PRKCE0.32479843
133CDK150.28827965
134PAK10.27628251
135CAMK2G0.26447017
136ROCK20.24177287

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.99070263
2Parkinsons disease_Homo sapiens_hsa050125.26052011
3Ribosome_Homo sapiens_hsa030105.08376343
4Alzheimers disease_Homo sapiens_hsa050103.97753826
5Huntingtons disease_Homo sapiens_hsa050163.81610434
6Protein export_Homo sapiens_hsa030603.68947540
7Proteasome_Homo sapiens_hsa030503.28108552
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.22731847
9Cardiac muscle contraction_Homo sapiens_hsa042603.11895773
10RNA polymerase_Homo sapiens_hsa030202.20883158
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.01541392
12Collecting duct acid secretion_Homo sapiens_hsa049661.80944327
13Vibrio cholerae infection_Homo sapiens_hsa051101.70829083
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.63499313
15Pyrimidine metabolism_Homo sapiens_hsa002401.47721738
16One carbon pool by folate_Homo sapiens_hsa006701.42594099
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35371139
18Mismatch repair_Homo sapiens_hsa034301.31587253
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27188063
20Spliceosome_Homo sapiens_hsa030401.20096102
21Vitamin B6 metabolism_Homo sapiens_hsa007501.19671143
22Synaptic vesicle cycle_Homo sapiens_hsa047211.18584058
23DNA replication_Homo sapiens_hsa030301.17278655
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13774297
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10952591
26Sulfur metabolism_Homo sapiens_hsa009201.04400190
27Non-homologous end-joining_Homo sapiens_hsa034501.02625060
28Purine metabolism_Homo sapiens_hsa002301.02007615
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01030201
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99404076
31Butanoate metabolism_Homo sapiens_hsa006500.94576990
32Cysteine and methionine metabolism_Homo sapiens_hsa002700.94276823
33Renin-angiotensin system_Homo sapiens_hsa046140.92604611
34RNA degradation_Homo sapiens_hsa030180.87285772
35Homologous recombination_Homo sapiens_hsa034400.86373641
36Insulin secretion_Homo sapiens_hsa049110.84187869
37Basal transcription factors_Homo sapiens_hsa030220.83719316
38Nucleotide excision repair_Homo sapiens_hsa034200.82472947
39Peroxisome_Homo sapiens_hsa041460.81218593
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80419484
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77112998
42Alcoholism_Homo sapiens_hsa050340.76710857
43Pyruvate metabolism_Homo sapiens_hsa006200.75688475
44Amphetamine addiction_Homo sapiens_hsa050310.74403340
45RNA transport_Homo sapiens_hsa030130.73261226
46Sulfur relay system_Homo sapiens_hsa041220.72600335
47Taste transduction_Homo sapiens_hsa047420.70128754
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66496601
49Cell cycle_Homo sapiens_hsa041100.66052414
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65501221
51Metabolic pathways_Homo sapiens_hsa011000.65163977
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64714001
53Serotonergic synapse_Homo sapiens_hsa047260.64704541
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64285677
55Phenylalanine metabolism_Homo sapiens_hsa003600.62608072
56Steroid biosynthesis_Homo sapiens_hsa001000.62557071
57Systemic lupus erythematosus_Homo sapiens_hsa053220.62549387
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62382450
59African trypanosomiasis_Homo sapiens_hsa051430.62139094
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61902963
61Selenocompound metabolism_Homo sapiens_hsa004500.61830885
62Linoleic acid metabolism_Homo sapiens_hsa005910.59453387
63Nicotine addiction_Homo sapiens_hsa050330.58572124
64Biosynthesis of amino acids_Homo sapiens_hsa012300.57146542
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55272946
66Arachidonic acid metabolism_Homo sapiens_hsa005900.54972374
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54743444
68Fatty acid metabolism_Homo sapiens_hsa012120.54615871
69Type I diabetes mellitus_Homo sapiens_hsa049400.53803661
70Fatty acid degradation_Homo sapiens_hsa000710.53482267
71Tryptophan metabolism_Homo sapiens_hsa003800.53438090
72Chemical carcinogenesis_Homo sapiens_hsa052040.52383046
73Rheumatoid arthritis_Homo sapiens_hsa053230.52331392
74Phagosome_Homo sapiens_hsa041450.52103434
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51778679
76Tyrosine metabolism_Homo sapiens_hsa003500.51518671
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51063488
78Arginine and proline metabolism_Homo sapiens_hsa003300.50459368
79Base excision repair_Homo sapiens_hsa034100.50401110
80Dilated cardiomyopathy_Homo sapiens_hsa054140.49620523
81beta-Alanine metabolism_Homo sapiens_hsa004100.48022597
82Dopaminergic synapse_Homo sapiens_hsa047280.46288371
83Fatty acid elongation_Homo sapiens_hsa000620.46096072
84Cocaine addiction_Homo sapiens_hsa050300.45997017
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.45753070
86Circadian entrainment_Homo sapiens_hsa047130.45554691
87Carbon metabolism_Homo sapiens_hsa012000.45182696
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44453811
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44148325
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43865823
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43011983
92Long-term potentiation_Homo sapiens_hsa047200.42743505
93Glucagon signaling pathway_Homo sapiens_hsa049220.42152618
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41867845
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40878809
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.40716863
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37882509
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37765337
99Regulation of autophagy_Homo sapiens_hsa041400.35345378
100Vitamin digestion and absorption_Homo sapiens_hsa049770.35325481
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34262774
102Glutathione metabolism_Homo sapiens_hsa004800.34115682
103Retinol metabolism_Homo sapiens_hsa008300.33718176
104N-Glycan biosynthesis_Homo sapiens_hsa005100.33715232
105GABAergic synapse_Homo sapiens_hsa047270.33663045
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33553304
107Fructose and mannose metabolism_Homo sapiens_hsa000510.32856132
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32531898
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32446823
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31480209
111mRNA surveillance pathway_Homo sapiens_hsa030150.31084780
112Phototransduction_Homo sapiens_hsa047440.30791456
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30696041
114p53 signaling pathway_Homo sapiens_hsa041150.28735156
115Calcium signaling pathway_Homo sapiens_hsa040200.28038433
116Oocyte meiosis_Homo sapiens_hsa041140.28003330
117Galactose metabolism_Homo sapiens_hsa000520.27707601
118Morphine addiction_Homo sapiens_hsa050320.27525555
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26946949
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.26837179
121Nitrogen metabolism_Homo sapiens_hsa009100.25982502
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24823834
123Basal cell carcinoma_Homo sapiens_hsa052170.24495430
124Cholinergic synapse_Homo sapiens_hsa047250.23298900
125Mineral absorption_Homo sapiens_hsa049780.23143391
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22271734
127Olfactory transduction_Homo sapiens_hsa047400.21786714
128Long-term depression_Homo sapiens_hsa047300.21563155
129Fanconi anemia pathway_Homo sapiens_hsa034600.21249866
130Arginine biosynthesis_Homo sapiens_hsa002200.21182126
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.20401648
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18997385
133Renin secretion_Homo sapiens_hsa049240.18015897
134Fat digestion and absorption_Homo sapiens_hsa049750.16693397
135Folate biosynthesis_Homo sapiens_hsa007900.14263789
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.13981836
137Glutamatergic synapse_Homo sapiens_hsa047240.11317302
138Gap junction_Homo sapiens_hsa045400.10279014
139Propanoate metabolism_Homo sapiens_hsa006400.09871160
140Oxytocin signaling pathway_Homo sapiens_hsa049210.09188050
141Pancreatic secretion_Homo sapiens_hsa049720.09125498
142Epstein-Barr virus infection_Homo sapiens_hsa051690.08867333

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