Rank | Gene Set | Z-score |
---|---|---|
1 | ribosomal small subunit biogenesis (GO:0042274) | 7.59827781 |
2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 7.54384427 |
3 | viral transcription (GO:0019083) | 7.16615842 |
4 | ATP synthesis coupled proton transport (GO:0015986) | 7.05978673 |
5 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 7.05978673 |
6 | ribosomal small subunit assembly (GO:0000028) | 6.91271391 |
7 | translational termination (GO:0006415) | 6.85872001 |
8 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 6.68985707 |
9 | cotranslational protein targeting to membrane (GO:0006613) | 6.30761097 |
10 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 6.28681630 |
11 | protein targeting to ER (GO:0045047) | 6.22507390 |
12 | respiratory electron transport chain (GO:0022904) | 6.05586849 |
13 | protein localization to endoplasmic reticulum (GO:0070972) | 5.96179887 |
14 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 5.94591862 |
15 | electron transport chain (GO:0022900) | 5.92376606 |
16 | maturation of SSU-rRNA (GO:0030490) | 5.85657845 |
17 | translational elongation (GO:0006414) | 5.81871216 |
18 | chaperone-mediated protein transport (GO:0072321) | 5.67373899 |
19 | cellular protein complex disassembly (GO:0043624) | 5.39665136 |
20 | viral life cycle (GO:0019058) | 5.35737991 |
21 | translational initiation (GO:0006413) | 5.07001972 |
22 | protein complex biogenesis (GO:0070271) | 5.00124456 |
23 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.98977384 |
24 | NADH dehydrogenase complex assembly (GO:0010257) | 4.98977384 |
25 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.98977384 |
26 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.98254503 |
27 | ribosomal large subunit biogenesis (GO:0042273) | 4.97952389 |
28 | protein neddylation (GO:0045116) | 4.88708887 |
29 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.86273308 |
30 | termination of RNA polymerase III transcription (GO:0006386) | 4.86273308 |
31 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.75949777 |
32 | translation (GO:0006412) | 4.74433155 |
33 | proteasome assembly (GO:0043248) | 4.72072310 |
34 | DNA deamination (GO:0045006) | 4.71324718 |
35 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.60120117 |
36 | protein complex disassembly (GO:0043241) | 4.52741654 |
37 | pseudouridine synthesis (GO:0001522) | 4.35073982 |
38 | macromolecular complex disassembly (GO:0032984) | 4.34200363 |
39 | regulation of mitochondrial translation (GO:0070129) | 4.33196680 |
40 | respiratory chain complex IV assembly (GO:0008535) | 4.24607074 |
41 | GTP biosynthetic process (GO:0006183) | 4.20196384 |
42 | protein targeting to membrane (GO:0006612) | 4.12024002 |
43 | 7-methylguanosine mRNA capping (GO:0006370) | 4.10103969 |
44 | RNA capping (GO:0036260) | 4.09075031 |
45 | 7-methylguanosine RNA capping (GO:0009452) | 4.09075031 |
46 | cellular component biogenesis (GO:0044085) | 3.99401761 |
47 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.96625317 |
48 | protein targeting to mitochondrion (GO:0006626) | 3.95380141 |
49 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.90296224 |
50 | establishment of protein localization to mitochondrion (GO:0072655) | 3.82851149 |
51 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.81984417 |
52 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.81984417 |
53 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.81377049 |
54 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.78454533 |
55 | cytochrome complex assembly (GO:0017004) | 3.75937864 |
56 | peptidyl-histidine modification (GO:0018202) | 3.66940646 |
57 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.65380178 |
58 | oxidative phosphorylation (GO:0006119) | 3.64814165 |
59 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.61908055 |
60 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.59394621 |
61 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.57392254 |
62 | UTP biosynthetic process (GO:0006228) | 3.56178021 |
63 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.55185233 |
64 | protein localization to mitochondrion (GO:0070585) | 3.54210536 |
65 | inner mitochondrial membrane organization (GO:0007007) | 3.53419800 |
66 | ATP biosynthetic process (GO:0006754) | 3.49718405 |
67 | rRNA processing (GO:0006364) | 3.47783427 |
68 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.47580544 |
69 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.40655816 |
70 | base-excision repair, AP site formation (GO:0006285) | 3.40247286 |
71 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.39706035 |
72 | DNA replication checkpoint (GO:0000076) | 3.39005765 |
73 | mRNA catabolic process (GO:0006402) | 3.36484189 |
74 | hydrogen ion transmembrane transport (GO:1902600) | 3.36084356 |
75 | termination of RNA polymerase I transcription (GO:0006363) | 3.35511345 |
76 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.34742118 |
77 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.33774511 |
78 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.33505109 |
79 | rRNA metabolic process (GO:0016072) | 3.32241587 |
80 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.31832518 |
81 | L-methionine salvage (GO:0071267) | 3.31324103 |
82 | L-methionine biosynthetic process (GO:0071265) | 3.31324103 |
83 | amino acid salvage (GO:0043102) | 3.31324103 |
84 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.30604360 |
85 | negative regulation of ligase activity (GO:0051352) | 3.30604360 |
86 | spliceosomal snRNP assembly (GO:0000387) | 3.28993761 |
87 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.27719752 |
88 | transcription from RNA polymerase I promoter (GO:0006360) | 3.26751099 |
89 | protein-cofactor linkage (GO:0018065) | 3.25767489 |
90 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.25519759 |
91 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.25519759 |
92 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.25183042 |
93 | chromatin remodeling at centromere (GO:0031055) | 3.22513978 |
94 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.22254846 |
95 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.22254846 |
96 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.22254846 |
97 | rRNA methylation (GO:0031167) | 3.22025141 |
98 | intracellular protein transmembrane import (GO:0044743) | 3.19567670 |
99 | tRNA processing (GO:0008033) | 3.18828654 |
100 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.18429071 |
101 | protein K6-linked ubiquitination (GO:0085020) | 3.16510646 |
102 | CTP metabolic process (GO:0046036) | 3.16417788 |
103 | CTP biosynthetic process (GO:0006241) | 3.16417788 |
104 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.14933299 |
105 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.14933299 |
106 | maturation of 5.8S rRNA (GO:0000460) | 3.14398259 |
107 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.13310633 |
108 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.12948727 |
109 | CENP-A containing nucleosome assembly (GO:0034080) | 3.12752080 |
110 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.11000480 |
111 | mitochondrial transport (GO:0006839) | 3.09793755 |
112 | rRNA modification (GO:0000154) | 3.07713629 |
113 | UTP metabolic process (GO:0046051) | 3.07607257 |
114 | proton transport (GO:0015992) | 3.06912200 |
115 | metallo-sulfur cluster assembly (GO:0031163) | 3.04278952 |
116 | iron-sulfur cluster assembly (GO:0016226) | 3.04278952 |
117 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.03663891 |
118 | RNA catabolic process (GO:0006401) | 3.03626769 |
119 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.03408543 |
120 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.03188026 |
121 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.02116525 |
122 | kinetochore assembly (GO:0051382) | 3.00210156 |
123 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.96686675 |
124 | ncRNA processing (GO:0034470) | 2.96310624 |
125 | DNA strand elongation involved in DNA replication (GO:0006271) | 2.96021569 |
126 | ribosome biogenesis (GO:0042254) | 2.93033659 |
127 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.92998193 |
128 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.92884893 |
129 | replication fork processing (GO:0031297) | 2.92219951 |
Rank | Gene Set | Z-score |
---|---|---|
1 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 5.96797630 |
2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.05074327 |
3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.80030342 |
4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.43375227 |
5 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.40089395 |
6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.32567270 |
7 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 4.31239258 |
8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.87982104 |
9 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.75715404 |
10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.61139047 |
11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.48500934 |
12 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.40486870 |
13 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.20159638 |
14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.18893207 |
15 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.01412752 |
16 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.01279169 |
17 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.89621664 |
18 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.85541517 |
19 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.63520429 |
20 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.53899436 |
21 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.52172873 |
22 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.50100938 |
23 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.39933866 |
24 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.25634103 |
25 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.25130264 |
26 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.21679714 |
27 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.16481600 |
28 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 2.15691832 |
29 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.15679884 |
30 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.13917845 |
31 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.07983036 |
32 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.99441273 |
33 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.89272749 |
34 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.86918284 |
35 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.82056007 |
36 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.81966836 |
37 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.67954707 |
38 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.67669844 |
39 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.65503576 |
40 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.65354062 |
41 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.64417764 |
42 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.47886837 |
43 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.44278762 |
44 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.42855089 |
45 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.36546886 |
46 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.34808312 |
47 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.32280879 |
48 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.30919149 |
49 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.30732579 |
50 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.30456630 |
51 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.26435750 |
52 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.25492831 |
53 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.24732064 |
54 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.24701837 |
55 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.23904776 |
56 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.23642326 |
57 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.23194408 |
58 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.19211824 |
59 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.16277498 |
60 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.15837928 |
61 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.13341145 |
62 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.12141075 |
63 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.09826394 |
64 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.08589708 |
65 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.07978153 |
66 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.05022574 |
67 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.04843586 |
68 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.04222069 |
69 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.01954320 |
70 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.01263422 |
71 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.00897883 |
72 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.00036852 |
73 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.99082355 |
74 | VDR_22108803_ChIP-Seq_LS180_Human | 0.98984945 |
75 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.97851574 |
76 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.97757828 |
77 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.97732406 |
78 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.96381140 |
79 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.95209795 |
80 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.94613488 |
81 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.94460716 |
82 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.92994604 |
83 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.92266591 |
84 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.90225635 |
85 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.88240689 |
86 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.87100257 |
87 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.85257516 |
88 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.85042798 |
89 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.84739990 |
90 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.82920777 |
91 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.79657266 |
92 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.79645659 |
93 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.79045002 |
94 | ERA_21632823_ChIP-Seq_H3396_Human | 0.78935966 |
95 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.78859880 |
96 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.78368400 |
97 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.78295485 |
98 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.77944797 |
99 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.77926638 |
100 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.76644783 |
101 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.76628420 |
102 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.76138318 |
103 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.75856346 |
104 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.75628971 |
105 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.75372771 |
106 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.75284197 |
107 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.74874017 |
108 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.73980743 |
109 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.73556482 |
110 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.73492760 |
111 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.70712197 |
112 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.70460868 |
113 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.70029564 |
114 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.69332684 |
115 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.67971064 |
116 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.67243939 |
117 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.67195982 |
118 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.67103579 |
119 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.66536126 |
120 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.65248976 |
121 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.65225358 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0009379_abnormal_foot_pigmentation | 6.12398928 |
2 | MP0001529_abnormal_vocalization | 3.27493425 |
3 | MP0003136_yellow_coat_color | 3.15008709 |
4 | MP0010094_abnormal_chromosome_stability | 3.02326513 |
5 | MP0001905_abnormal_dopamine_level | 2.97150130 |
6 | MP0006036_abnormal_mitochondrial_physio | 2.76012056 |
7 | MP0003111_abnormal_nucleus_morphology | 2.62483117 |
8 | MP0006035_abnormal_mitochondrial_morpho | 2.29517753 |
9 | MP0003693_abnormal_embryo_hatching | 2.24654476 |
10 | MP0003011_delayed_dark_adaptation | 2.24450279 |
11 | MP0002638_abnormal_pupillary_reflex | 2.20660444 |
12 | MP0000372_irregular_coat_pigmentation | 2.19262625 |
13 | MP0004381_abnormal_hair_follicle | 2.14693657 |
14 | MP0003880_abnormal_central_pattern | 2.12354016 |
15 | MP0008877_abnormal_DNA_methylation | 2.02573491 |
16 | MP0008007_abnormal_cellular_replicative | 2.01723516 |
17 | MP0002163_abnormal_gland_morphology | 1.98506688 |
18 | MP0006292_abnormal_olfactory_placode | 1.98382234 |
19 | MP0001986_abnormal_taste_sensitivity | 1.91849163 |
20 | MP0004142_abnormal_muscle_tone | 1.91473978 |
21 | MP0003186_abnormal_redox_activity | 1.90854985 |
22 | MP0005409_darkened_coat_color | 1.86690004 |
23 | MP0003718_maternal_effect | 1.83182932 |
24 | MP0006276_abnormal_autonomic_nervous | 1.80835900 |
25 | MP0005451_abnormal_body_composition | 1.76342219 |
26 | MP0003806_abnormal_nucleotide_metabolis | 1.75549602 |
27 | MP0002837_dystrophic_cardiac_calcinosis | 1.75168801 |
28 | MP0001188_hyperpigmentation | 1.74500166 |
29 | MP0008260_abnormal_autophagy | 1.73637475 |
30 | MP0005379_endocrine/exocrine_gland_phen | 1.71879689 |
31 | MP0003646_muscle_fatigue | 1.66931679 |
32 | MP0002132_abnormal_respiratory_system | 1.64146880 |
33 | MP0002653_abnormal_ependyma_morphology | 1.63021202 |
34 | MP0005084_abnormal_gallbladder_morpholo | 1.62180830 |
35 | MP0003724_increased_susceptibility_to | 1.60311234 |
36 | MP0004957_abnormal_blastocyst_morpholog | 1.56359670 |
37 | MP0008872_abnormal_physiological_respon | 1.47517419 |
38 | MP0005389_reproductive_system_phenotype | 1.45798980 |
39 | MP0004147_increased_porphyrin_level | 1.44727264 |
40 | MP0008875_abnormal_xenobiotic_pharmacok | 1.43636287 |
41 | MP0010030_abnormal_orbit_morphology | 1.41421463 |
42 | MP0001764_abnormal_homeostasis | 1.40854522 |
43 | MP0008058_abnormal_DNA_repair | 1.40338698 |
44 | MP0002938_white_spotting | 1.40047398 |
45 | MP0006072_abnormal_retinal_apoptosis | 1.38906004 |
46 | MP0001919_abnormal_reproductive_system | 1.36485368 |
47 | MP0008932_abnormal_embryonic_tissue | 1.36121112 |
48 | MP0003123_paternal_imprinting | 1.35787032 |
49 | MP0002234_abnormal_pharynx_morphology | 1.35605509 |
50 | MP0003195_calcinosis | 1.31053023 |
51 | MP0009333_abnormal_splenocyte_physiolog | 1.28519827 |
52 | MP0003786_premature_aging | 1.28481109 |
53 | MP0005551_abnormal_eye_electrophysiolog | 1.26314586 |
54 | MP0005646_abnormal_pituitary_gland | 1.25222005 |
55 | MP0002210_abnormal_sex_determination | 1.25132023 |
56 | MP0003950_abnormal_plasma_membrane | 1.24231898 |
57 | MP0001293_anophthalmia | 1.23536067 |
58 | MP0005408_hypopigmentation | 1.23500253 |
59 | MP0002736_abnormal_nociception_after | 1.22826883 |
60 | MP0008995_early_reproductive_senescence | 1.22198717 |
61 | MP0005645_abnormal_hypothalamus_physiol | 1.19962930 |
62 | MP0002876_abnormal_thyroid_physiology | 1.19824886 |
63 | MP0000049_abnormal_middle_ear | 1.19610039 |
64 | MP0005075_abnormal_melanosome_morpholog | 1.19411528 |
65 | MP0005171_absent_coat_pigmentation | 1.18284396 |
66 | MP0001727_abnormal_embryo_implantation | 1.14783476 |
67 | MP0000749_muscle_degeneration | 1.14237583 |
68 | MP0002102_abnormal_ear_morphology | 1.08629837 |
69 | MP0002277_abnormal_respiratory_mucosa | 1.08191388 |
70 | MP0001929_abnormal_gametogenesis | 1.07019175 |
71 | MP0001661_extended_life_span | 1.04690034 |
72 | MP0000631_abnormal_neuroendocrine_gland | 1.04140539 |
73 | MP0005671_abnormal_response_to | 1.00622241 |
74 | MP0005636_abnormal_mineral_homeostasis | 0.99723462 |
75 | MP0004742_abnormal_vestibular_system | 0.99603628 |
76 | MP0001145_abnormal_male_reproductive | 0.98899841 |
77 | MP0000920_abnormal_myelination | 0.98188256 |
78 | MP0001968_abnormal_touch/_nociception | 0.97948930 |
79 | MP0008057_abnormal_DNA_replication | 0.97866739 |
80 | MP0003315_abnormal_perineum_morphology | 0.97517568 |
81 | MP0002148_abnormal_hypersensitivity_rea | 0.95716370 |
82 | MP0000653_abnormal_sex_gland | 0.94594309 |
83 | MP0000566_synostosis | 0.92479332 |
84 | MP0004145_abnormal_muscle_electrophysio | 0.91201836 |
85 | MP0002272_abnormal_nervous_system | 0.90926696 |
86 | MP0003077_abnormal_cell_cycle | 0.90365151 |
87 | MP0004036_abnormal_muscle_relaxation | 0.89095064 |
88 | MP0009697_abnormal_copulation | 0.88494503 |
89 | MP0005253_abnormal_eye_physiology | 0.86392640 |
90 | MP0001485_abnormal_pinna_reflex | 0.86331147 |
91 | MP0002751_abnormal_autonomic_nervous | 0.86280224 |
92 | MP0000026_abnormal_inner_ear | 0.84766569 |
93 | MP0009785_altered_susceptibility_to | 0.83484712 |
94 | MP0004043_abnormal_pH_regulation | 0.83094260 |
95 | MP0005174_abnormal_tail_pigmentation | 0.82689038 |
96 | MP0000681_abnormal_thyroid_gland | 0.82504340 |
97 | MP0003698_abnormal_male_reproductive | 0.80665259 |
98 | MP0005330_cardiomyopathy | 0.79985787 |
99 | MP0000313_abnormal_cell_death | 0.79256128 |
100 | MP0000750_abnormal_muscle_regeneration | 0.78191878 |
101 | MP0004215_abnormal_myocardial_fiber | 0.77785967 |
102 | MP0002735_abnormal_chemical_nociception | 0.77521585 |
103 | MP0001542_abnormal_bone_strength | 0.76424428 |
104 | MP0002332_abnormal_exercise_endurance | 0.75560738 |
105 | MP0003137_abnormal_impulse_conducting | 0.75032233 |
106 | MP0004019_abnormal_vitamin_homeostasis | 0.75023817 |
107 | MP0003937_abnormal_limbs/digits/tail_de | 0.74335998 |
108 | MP0000358_abnormal_cell_content/ | 0.74082183 |
109 | MP0002095_abnormal_skin_pigmentation | 0.73785626 |
110 | MP0005410_abnormal_fertilization | 0.72346781 |
111 | MP0000647_abnormal_sebaceous_gland | 0.72208382 |
112 | MP0005376_homeostasis/metabolism_phenot | 0.70889630 |
113 | MP0003938_abnormal_ear_development | 0.69441594 |
114 | MP0000350_abnormal_cell_proliferation | 0.68948842 |
115 | MP0005394_taste/olfaction_phenotype | 0.68614370 |
116 | MP0005499_abnormal_olfactory_system | 0.68614370 |
117 | MP0002752_abnormal_somatic_nervous | 0.68540948 |
118 | MP0001324_abnormal_eye_pigmentation | 0.67670553 |
119 | MP0005395_other_phenotype | 0.67402024 |
120 | MP0003283_abnormal_digestive_organ | 0.67092556 |
121 | MP0010386_abnormal_urinary_bladder | 0.65760426 |
122 | MP0001119_abnormal_female_reproductive | 0.65469303 |
123 | MP0005266_abnormal_metabolism | 0.65431328 |
124 | MP0002111_abnormal_tail_morphology | 0.64222024 |
125 | MP0003119_abnormal_digestive_system | 0.64062275 |
126 | MP0008789_abnormal_olfactory_epithelium | 0.63817549 |
127 | MP0002734_abnormal_mechanical_nocicepti | 0.63529468 |
128 | MP0003656_abnormal_erythrocyte_physiolo | 0.63450539 |
129 | MP0001963_abnormal_hearing_physiology | 0.63423025 |
130 | MP0003121_genomic_imprinting | 0.62632340 |
131 | MP0001853_heart_inflammation | 0.62443307 |
132 | MP0005332_abnormal_amino_acid | 0.62259604 |
133 | MP0001970_abnormal_pain_threshold | 0.61700024 |
134 | MP0005083_abnormal_biliary_tract | 0.61636742 |
135 | MP0002067_abnormal_sensory_capabilities | 0.61314200 |
136 | MP0001835_abnormal_antigen_presentation | 0.60167290 |
137 | MP0003567_abnormal_fetal_cardiomyocyte | 0.59842511 |
138 | MP0009046_muscle_twitch | 0.59774967 |
139 | MP0002160_abnormal_reproductive_system | 0.59380193 |
140 | MP0001697_abnormal_embryo_size | 0.58861497 |
141 | MP0004133_heterotaxia | 0.58747719 |
142 | MP0005670_abnormal_white_adipose | 0.57835077 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 6.52562690 |
2 | Mitochondrial inheritance (HP:0001427) | 5.98661001 |
3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.83735217 |
4 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.51223076 |
5 | Hepatocellular necrosis (HP:0001404) | 5.48964255 |
6 | Progressive macrocephaly (HP:0004481) | 5.47210452 |
7 | Acute encephalopathy (HP:0006846) | 5.35942647 |
8 | Increased CSF lactate (HP:0002490) | 5.19503864 |
9 | Increased hepatocellular lipid droplets (HP:0006565) | 5.15245796 |
10 | Abnormal number of erythroid precursors (HP:0012131) | 5.01864457 |
11 | Hepatic necrosis (HP:0002605) | 5.01097836 |
12 | Lipid accumulation in hepatocytes (HP:0006561) | 4.78446055 |
13 | 3-Methylglutaconic aciduria (HP:0003535) | 4.67672588 |
14 | Reticulocytopenia (HP:0001896) | 4.44923537 |
15 | Renal Fanconi syndrome (HP:0001994) | 4.44456144 |
16 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.41968486 |
17 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.41968486 |
18 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 4.34913322 |
19 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 4.08996135 |
20 | Macrocytic anemia (HP:0001972) | 3.98916537 |
21 | Cerebral edema (HP:0002181) | 3.90552964 |
22 | Increased intramyocellular lipid droplets (HP:0012240) | 3.78999247 |
23 | Abnormality of glycolysis (HP:0004366) | 3.75887108 |
24 | Increased serum pyruvate (HP:0003542) | 3.75887108 |
25 | Exercise intolerance (HP:0003546) | 3.71965855 |
26 | Increased serum lactate (HP:0002151) | 3.70713900 |
27 | Respiratory failure (HP:0002878) | 3.66330906 |
28 | Lactic acidosis (HP:0003128) | 3.62987378 |
29 | Exertional dyspnea (HP:0002875) | 3.59180611 |
30 | Optic disc pallor (HP:0000543) | 3.55092725 |
31 | Increased muscle lipid content (HP:0009058) | 3.41822247 |
32 | Respiratory difficulties (HP:0002880) | 3.27476525 |
33 | Pallor (HP:0000980) | 3.23711786 |
34 | Leukodystrophy (HP:0002415) | 3.22545520 |
35 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 3.01070947 |
36 | Abnormality of renal resorption (HP:0011038) | 2.83296114 |
37 | Microvesicular hepatic steatosis (HP:0001414) | 2.76540577 |
38 | Hypothermia (HP:0002045) | 2.72562171 |
39 | Testicular atrophy (HP:0000029) | 2.57604902 |
40 | CNS demyelination (HP:0007305) | 2.55850881 |
41 | Parakeratosis (HP:0001036) | 2.54993353 |
42 | Pancreatic cysts (HP:0001737) | 2.51538982 |
43 | Cerebral hypomyelination (HP:0006808) | 2.50860331 |
44 | Type I transferrin isoform profile (HP:0003642) | 2.50367185 |
45 | Absent thumb (HP:0009777) | 2.47159266 |
46 | Lethargy (HP:0001254) | 2.43262453 |
47 | Pendular nystagmus (HP:0012043) | 2.33352395 |
48 | Glycosuria (HP:0003076) | 2.31501833 |
49 | Abnormality of urine glucose concentration (HP:0011016) | 2.31501833 |
50 | Emotional lability (HP:0000712) | 2.29707094 |
51 | Molar tooth sign on MRI (HP:0002419) | 2.26035190 |
52 | Abnormality of midbrain morphology (HP:0002418) | 2.26035190 |
53 | Pancreatic fibrosis (HP:0100732) | 2.23254050 |
54 | Abnormality of placental membranes (HP:0011409) | 2.20701582 |
55 | Amniotic constriction ring (HP:0009775) | 2.20701582 |
56 | X-linked dominant inheritance (HP:0001423) | 2.19704860 |
57 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.19081214 |
58 | Microretrognathia (HP:0000308) | 2.16462301 |
59 | Hyperphosphaturia (HP:0003109) | 2.11808191 |
60 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.08372446 |
61 | Abnormality of the axillary hair (HP:0100134) | 2.05613594 |
62 | Abnormality of secondary sexual hair (HP:0009888) | 2.05613594 |
63 | Sclerocornea (HP:0000647) | 2.03574725 |
64 | Abnormality of alanine metabolism (HP:0010916) | 2.01537418 |
65 | Hyperalaninemia (HP:0003348) | 2.01537418 |
66 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.01537418 |
67 | Hyperglycinemia (HP:0002154) | 2.01195528 |
68 | Generalized aminoaciduria (HP:0002909) | 2.00827915 |
69 | Meckel diverticulum (HP:0002245) | 2.00616871 |
70 | Hypoplasia of the pons (HP:0012110) | 1.99585330 |
71 | Abnormality of the ileum (HP:0001549) | 1.99341480 |
72 | True hermaphroditism (HP:0010459) | 1.96595653 |
73 | Progressive microcephaly (HP:0000253) | 1.95925730 |
74 | Horseshoe kidney (HP:0000085) | 1.94731162 |
75 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.93988887 |
76 | Colon cancer (HP:0003003) | 1.93172835 |
77 | Abnormality of the pons (HP:0007361) | 1.93166715 |
78 | Congenital stationary night blindness (HP:0007642) | 1.92765794 |
79 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.89350695 |
80 | Aplastic anemia (HP:0001915) | 1.88580032 |
81 | Breast hypoplasia (HP:0003187) | 1.88006798 |
82 | Cleft eyelid (HP:0000625) | 1.86914443 |
83 | Progressive external ophthalmoplegia (HP:0000590) | 1.86489010 |
84 | Abnormality of serum amino acid levels (HP:0003112) | 1.86187123 |
85 | Abnormality of the preputium (HP:0100587) | 1.84518565 |
86 | Abnormal hemoglobin (HP:0011902) | 1.83842326 |
87 | Nephronophthisis (HP:0000090) | 1.82421996 |
88 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.81615861 |
89 | Dicarboxylic aciduria (HP:0003215) | 1.81615861 |
90 | Concave nail (HP:0001598) | 1.80173931 |
91 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.79484803 |
92 | Blindness (HP:0000618) | 1.78576196 |
93 | Abnormal urine phosphate concentration (HP:0012599) | 1.77339985 |
94 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.76963424 |
95 | Congenital, generalized hypertrichosis (HP:0004540) | 1.74906891 |
96 | Renal tubular dysfunction (HP:0000124) | 1.74840053 |
97 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.72440622 |
98 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.72315440 |
99 | Rib fusion (HP:0000902) | 1.71269031 |
100 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.71021004 |
101 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.71021004 |
102 | Abnormal protein glycosylation (HP:0012346) | 1.71021004 |
103 | Abnormal glycosylation (HP:0012345) | 1.71021004 |
104 | Medial flaring of the eyebrow (HP:0010747) | 1.69708853 |
105 | Chromsome breakage (HP:0040012) | 1.69531314 |
106 | Methylmalonic aciduria (HP:0012120) | 1.69266984 |
107 | Birth length less than 3rd percentile (HP:0003561) | 1.68367442 |
108 | Triphalangeal thumb (HP:0001199) | 1.67792628 |
109 | Partial duplication of thumb phalanx (HP:0009944) | 1.67355029 |
110 | Type 2 muscle fiber atrophy (HP:0003554) | 1.67346392 |
111 | Progressive muscle weakness (HP:0003323) | 1.67273421 |
112 | Gliosis (HP:0002171) | 1.65935447 |
113 | Spastic paraparesis (HP:0002313) | 1.62688535 |
114 | CNS hypomyelination (HP:0003429) | 1.62354968 |
115 | Patellar aplasia (HP:0006443) | 1.62019538 |
116 | Abnormal pupillary function (HP:0007686) | 1.61062118 |
117 | Reduced antithrombin III activity (HP:0001976) | 1.60708894 |
118 | Delusions (HP:0000746) | 1.60426063 |
119 | Abnormality of methionine metabolism (HP:0010901) | 1.60315855 |
120 | Muscle fiber atrophy (HP:0100295) | 1.59657015 |
121 | Pancytopenia (HP:0001876) | 1.57643498 |
122 | Multiple enchondromatosis (HP:0005701) | 1.53414976 |
123 | Secondary amenorrhea (HP:0000869) | 1.52588388 |
124 | Rough bone trabeculation (HP:0100670) | 1.52332226 |
125 | Nausea (HP:0002018) | 1.49483243 |
126 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.46648564 |
127 | Oral leukoplakia (HP:0002745) | 1.44986430 |
128 | External ophthalmoplegia (HP:0000544) | 1.43849579 |
129 | Vomiting (HP:0002013) | 1.43432124 |
130 | Stenosis of the external auditory canal (HP:0000402) | 1.42975542 |
131 | Methylmalonic acidemia (HP:0002912) | 1.42868546 |
132 | Neuroendocrine neoplasm (HP:0100634) | 1.42840868 |
133 | Patchy hypopigmentation of hair (HP:0011365) | 1.42467312 |
134 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.42209208 |
Rank | Gene Set | Z-score |
---|---|---|
1 | VRK2 | 5.55339465 |
2 | NME2 | 4.40821985 |
3 | STK16 | 4.18786530 |
4 | BUB1 | 2.85510474 |
5 | NME1 | 2.68289268 |
6 | CASK | 2.60538149 |
7 | EIF2AK1 | 2.54458163 |
8 | TLK1 | 2.53623687 |
9 | CDC7 | 2.52210250 |
10 | CDK19 | 2.44974265 |
11 | BCKDK | 2.36928085 |
12 | VRK1 | 2.19326795 |
13 | NUAK1 | 2.18193891 |
14 | WEE1 | 2.10726098 |
15 | SRPK1 | 2.10155328 |
16 | MST4 | 2.07571675 |
17 | MUSK | 1.96585641 |
18 | EIF2AK3 | 1.94869723 |
19 | MAPKAPK5 | 1.86783465 |
20 | NEK1 | 1.83830113 |
21 | MAP3K12 | 1.78105416 |
22 | STK39 | 1.77677107 |
23 | MYLK | 1.69521757 |
24 | ARAF | 1.64575566 |
25 | TNIK | 1.63901964 |
26 | GRK7 | 1.62731884 |
27 | PIM2 | 1.59845679 |
28 | TAF1 | 1.53966388 |
29 | WNK3 | 1.51170340 |
30 | PLK4 | 1.47178272 |
31 | PBK | 1.39681280 |
32 | ADRBK2 | 1.35635510 |
33 | MAP4K2 | 1.34395260 |
34 | OXSR1 | 1.31292520 |
35 | KDR | 1.27145576 |
36 | TESK2 | 1.23844201 |
37 | TSSK6 | 1.22585995 |
38 | DYRK2 | 1.21897044 |
39 | MKNK1 | 1.21194354 |
40 | TTK | 1.16021376 |
41 | CHEK2 | 1.08713042 |
42 | MKNK2 | 1.05852325 |
43 | TRIM28 | 1.04475541 |
44 | PDK2 | 1.03040724 |
45 | PNCK | 1.02613129 |
46 | NEK2 | 1.01400785 |
47 | TESK1 | 0.99970708 |
48 | BRAF | 0.99005963 |
49 | DYRK3 | 0.97266496 |
50 | ATR | 0.96547139 |
51 | GRK5 | 0.96293665 |
52 | BRSK2 | 0.95084062 |
53 | INSRR | 0.94967857 |
54 | EIF2AK2 | 0.94454739 |
55 | IRAK4 | 0.94183006 |
56 | CSNK1G3 | 0.94138219 |
57 | PRKCI | 0.94071167 |
58 | OBSCN | 0.90139257 |
59 | RPS6KA5 | 0.88402520 |
60 | BMPR1B | 0.86782938 |
61 | LIMK1 | 0.85004058 |
62 | ABL2 | 0.82357757 |
63 | TEC | 0.80936327 |
64 | CDK3 | 0.80571359 |
65 | BLK | 0.79786511 |
66 | MAP2K7 | 0.78470026 |
67 | PHKG1 | 0.77746759 |
68 | PHKG2 | 0.77746759 |
69 | STK4 | 0.75855286 |
70 | TXK | 0.75344779 |
71 | CSNK1G2 | 0.74655457 |
72 | PKN1 | 0.73679994 |
73 | CDK8 | 0.72532564 |
74 | CCNB1 | 0.71725208 |
75 | DAPK1 | 0.71042676 |
76 | DAPK3 | 0.70692826 |
77 | CSNK2A1 | 0.70647974 |
78 | BMPR2 | 0.70504139 |
79 | IRAK2 | 0.70481226 |
80 | AURKA | 0.69601071 |
81 | CSNK2A2 | 0.68972506 |
82 | NLK | 0.67686672 |
83 | CSNK1A1L | 0.65883457 |
84 | CSNK1G1 | 0.65382462 |
85 | FRK | 0.65119920 |
86 | MAPKAPK3 | 0.63897388 |
87 | IRAK3 | 0.61857111 |
88 | ILK | 0.60668913 |
89 | IRAK1 | 0.59330204 |
90 | BCR | 0.58378783 |
91 | ACVR1B | 0.57773508 |
92 | ADRBK1 | 0.55367366 |
93 | CAMK2B | 0.55016479 |
94 | MAPK13 | 0.54288028 |
95 | AKT3 | 0.52733758 |
96 | GRK1 | 0.52110105 |
97 | PINK1 | 0.51948299 |
98 | WNK4 | 0.51820896 |
99 | PLK1 | 0.50852579 |
100 | MAP4K1 | 0.50799182 |
101 | EPHA2 | 0.47320453 |
102 | PAK1 | 0.46932078 |
103 | CHEK1 | 0.45524371 |
104 | MAPK4 | 0.45350242 |
105 | YES1 | 0.44908601 |
106 | CAMK2G | 0.44573758 |
107 | CDK7 | 0.43764684 |
108 | NEK6 | 0.42743084 |
109 | LYN | 0.42292759 |
110 | AURKB | 0.41956805 |
111 | TIE1 | 0.41644973 |
112 | PIK3CG | 0.41547536 |
113 | PRKCG | 0.40903846 |
114 | PDK4 | 0.40815186 |
115 | PDK3 | 0.40815186 |
116 | RPS6KB2 | 0.40368831 |
117 | MAP3K11 | 0.40140589 |
118 | CSNK1A1 | 0.38554901 |
119 | LRRK2 | 0.38437915 |
120 | ZAK | 0.38326143 |
121 | MAPK15 | 0.38200137 |
122 | PRKACA | 0.37913723 |
123 | MAP2K6 | 0.37077880 |
124 | PLK3 | 0.36994117 |
125 | FES | 0.36486224 |
126 | UHMK1 | 0.35850186 |
127 | CAMK2D | 0.35632050 |
128 | IKBKB | 0.35278136 |
129 | MAP3K4 | 0.34336743 |
130 | ATM | 0.33813784 |
131 | RPS6KA4 | 0.31235595 |
132 | PASK | 0.30431173 |
133 | GRK6 | 0.30378211 |
134 | BRSK1 | 0.29178917 |
135 | CDK1 | 0.25988776 |
136 | CSNK1E | 0.25437055 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ribosome_Homo sapiens_hsa03010 | 5.90385585 |
2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 5.16356579 |
3 | Parkinsons disease_Homo sapiens_hsa05012 | 4.43835534 |
4 | Proteasome_Homo sapiens_hsa03050 | 3.97121076 |
5 | RNA polymerase_Homo sapiens_hsa03020 | 3.81675839 |
6 | Huntingtons disease_Homo sapiens_hsa05016 | 3.24725655 |
7 | Protein export_Homo sapiens_hsa03060 | 3.21835685 |
8 | Alzheimers disease_Homo sapiens_hsa05010 | 3.18617472 |
9 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.85567071 |
10 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.22312168 |
11 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.93581933 |
12 | Spliceosome_Homo sapiens_hsa03040 | 1.89604691 |
13 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.81268899 |
14 | DNA replication_Homo sapiens_hsa03030 | 1.74767875 |
15 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.63339623 |
16 | Homologous recombination_Homo sapiens_hsa03440 | 1.55706007 |
17 | Mismatch repair_Homo sapiens_hsa03430 | 1.54860538 |
18 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.52261558 |
19 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.50566674 |
20 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.38737985 |
21 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.38016656 |
22 | Purine metabolism_Homo sapiens_hsa00230 | 1.37092382 |
23 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.34974751 |
24 | Basal transcription factors_Homo sapiens_hsa03022 | 1.33381617 |
25 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.23280095 |
26 | Phototransduction_Homo sapiens_hsa04744 | 1.16815507 |
27 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.15699651 |
28 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.12386722 |
29 | RNA transport_Homo sapiens_hsa03013 | 1.04564313 |
30 | Base excision repair_Homo sapiens_hsa03410 | 1.04243281 |
31 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.00506292 |
32 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.97612806 |
33 | RNA degradation_Homo sapiens_hsa03018 | 0.96856420 |
34 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.95490618 |
35 | Metabolic pathways_Homo sapiens_hsa01100 | 0.94096336 |
36 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.92971203 |
37 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.92506236 |
38 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.91580556 |
39 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.90770229 |
40 | Sulfur relay system_Homo sapiens_hsa04122 | 0.88524361 |
41 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.85560083 |
42 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.85132119 |
43 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.83890652 |
44 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.82164955 |
45 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.79785222 |
46 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.76137866 |
47 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.74882394 |
48 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.72274496 |
49 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.72092791 |
50 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.69885643 |
51 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.65087941 |
52 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.65005067 |
53 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.64105399 |
54 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.63369888 |
55 | Histidine metabolism_Homo sapiens_hsa00340 | 0.58729834 |
56 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.58551321 |
57 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.58279491 |
58 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.58007449 |
59 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.57998607 |
60 | Peroxisome_Homo sapiens_hsa04146 | 0.57597500 |
61 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.56764251 |
62 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.56421726 |
63 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.56256431 |
64 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.55526880 |
65 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.55151700 |
66 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.54652246 |
67 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.54003082 |
68 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.53818632 |
69 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.53234630 |
70 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.53126894 |
71 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.52636404 |
72 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.49811079 |
73 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.49636886 |
74 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.49429751 |
75 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.48677511 |
76 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.46656662 |
77 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.46336133 |
78 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.45042371 |
79 | Carbon metabolism_Homo sapiens_hsa01200 | 0.44365189 |
80 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.42172883 |
81 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.42058796 |
82 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.41322861 |
83 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.40628054 |
84 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.39286863 |
85 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.38308981 |
86 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.37678552 |
87 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.36898379 |
88 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.36014867 |
89 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.32572191 |
90 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.29051682 |
91 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.28480615 |
92 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.28451908 |
93 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.28142856 |
94 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.27679409 |
95 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.27372596 |
96 | Retinol metabolism_Homo sapiens_hsa00830 | 0.25012523 |
97 | Cell cycle_Homo sapiens_hsa04110 | 0.24147579 |
98 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.23198641 |
99 | Other glycan degradation_Homo sapiens_hsa00511 | 0.21696862 |
100 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.21344008 |
101 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.20757442 |
102 | Allograft rejection_Homo sapiens_hsa05330 | 0.19458420 |
103 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.18781294 |
104 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.17743398 |
105 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.17413574 |
106 | Asthma_Homo sapiens_hsa05310 | 0.16680857 |
107 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.14740147 |
108 | Phagosome_Homo sapiens_hsa04145 | 0.14298138 |
109 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.12601485 |
110 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.12330595 |
111 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.10298790 |
112 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.09841407 |
113 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.09292341 |
114 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.05433176 |
115 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.04781246 |
116 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.03948477 |