UQCR10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.55353702
2* respiratory electron transport chain (GO:0022904)8.85064648
3* electron transport chain (GO:0022900)8.61896025
4ATP biosynthetic process (GO:0006754)5.72993898
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.66235206
6protein complex biogenesis (GO:0070271)5.57673402
7chaperone-mediated protein transport (GO:0072321)5.46757293
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.39131076
9mitochondrial respiratory chain complex I assembly (GO:0032981)5.39131076
10NADH dehydrogenase complex assembly (GO:0010257)5.39131076
11purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.32658932
12oxidative phosphorylation (GO:0006119)5.26470043
13purine nucleoside triphosphate biosynthetic process (GO:0009145)5.24520420
14* hydrogen ion transmembrane transport (GO:1902600)5.16111539
15mitochondrial respiratory chain complex assembly (GO:0033108)5.10825391
16protein neddylation (GO:0045116)4.96052486
17inner mitochondrial membrane organization (GO:0007007)4.87611162
18ribonucleoside triphosphate biosynthetic process (GO:0009201)4.65973813
19regulation of mitochondrial translation (GO:0070129)4.53106742
20* proton transport (GO:0015992)4.52067693
21* hydrogen transport (GO:0006818)4.44204203
22ribosomal small subunit biogenesis (GO:0042274)4.40492340
23viral transcription (GO:0019083)4.19508795
24protein complex disassembly (GO:0043241)4.18913990
25macromolecular complex disassembly (GO:0032984)4.03502574
26translational termination (GO:0006415)4.02344993
27nucleoside triphosphate biosynthetic process (GO:0009142)4.01314077
28protein targeting to membrane (GO:0006612)3.94807274
29GTP biosynthetic process (GO:0006183)3.91486549
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.87880736
31sequestering of actin monomers (GO:0042989)3.85580530
32mitochondrial transport (GO:0006839)3.82794079
33regulation of oxidative phosphorylation (GO:0002082)3.79186645
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.74839167
35protein targeting to mitochondrion (GO:0006626)3.73376199
36establishment of protein localization to mitochondrion (GO:0072655)3.70653111
37cotranslational protein targeting to membrane (GO:0006613)3.69738467
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.67369991
39aerobic respiration (GO:0009060)3.64430232
40protein targeting to ER (GO:0045047)3.62139583
41tricarboxylic acid cycle (GO:0006099)3.61019648
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.58781201
43nuclear-transcribed mRNA catabolic process (GO:0000956)3.55753894
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.54876080
45negative regulation of ligase activity (GO:0051352)3.52346400
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.52346400
47respiratory chain complex IV assembly (GO:0008535)3.52181860
48protein localization to mitochondrion (GO:0070585)3.51693366
49regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.48228848
50establishment of protein localization to endoplasmic reticulum (GO:0072599)3.48139472
51protein localization to endoplasmic reticulum (GO:0070972)3.48013944
52purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.47432909
53purine nucleoside monophosphate biosynthetic process (GO:0009127)3.47432909
54rRNA modification (GO:0000154)3.45342711
55dopamine transport (GO:0015872)3.42694023
56quinone biosynthetic process (GO:1901663)3.35863729
57ubiquinone biosynthetic process (GO:0006744)3.35863729
58ribosomal small subunit assembly (GO:0000028)3.35514178
59mRNA catabolic process (GO:0006402)3.35017953
60translational elongation (GO:0006414)3.34325561
61cytochrome complex assembly (GO:0017004)3.33196600
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.30271976
63water-soluble vitamin biosynthetic process (GO:0042364)3.28357248
64DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.28225764
65spliceosomal snRNP assembly (GO:0000387)3.28130337
66regulation of cellular respiration (GO:0043457)3.27714473
67tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27700346
68RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27700346
69proteasome assembly (GO:0043248)3.24411077
70cellular protein complex disassembly (GO:0043624)3.23648851
71UTP biosynthetic process (GO:0006228)3.22986423
72ATP hydrolysis coupled proton transport (GO:0015991)3.20248744
73energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.20248744
74signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.20203638
75signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.20203638
76signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.20203638
77pseudouridine synthesis (GO:0001522)3.20038056
78intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.17844979
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.17844979
80viral life cycle (GO:0019058)3.16394455
81translation (GO:0006412)3.15290516
82ribonucleoprotein complex biogenesis (GO:0022613)3.15165595
83chromatin remodeling at centromere (GO:0031055)3.14686434
84* generation of precursor metabolites and energy (GO:0006091)3.13382637
85ubiquinone metabolic process (GO:0006743)3.11977942
86fatty acid elongation (GO:0030497)3.10036404
87intracellular protein transmembrane import (GO:0044743)3.09364080
88NADH metabolic process (GO:0006734)3.08625803
89CENP-A containing nucleosome assembly (GO:0034080)3.08110387
90ribosomal large subunit biogenesis (GO:0042273)3.07254157
91signal transduction involved in DNA damage checkpoint (GO:0072422)3.06474885
92signal transduction involved in DNA integrity checkpoint (GO:0072401)3.06474885
93positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04700483
94signal transduction involved in cell cycle checkpoint (GO:0072395)3.04078274
95RNA catabolic process (GO:0006401)3.03979800
96purine nucleoside biosynthetic process (GO:0042451)3.03936618
97purine ribonucleoside biosynthetic process (GO:0046129)3.03936618
98substantia nigra development (GO:0021762)3.01696889
99spliceosomal complex assembly (GO:0000245)2.99240920
100axon ensheathment in central nervous system (GO:0032291)2.99123332
101central nervous system myelination (GO:0022010)2.99123332
102rRNA processing (GO:0006364)2.96196544
103transcription elongation from RNA polymerase III promoter (GO:0006385)2.95884629
104termination of RNA polymerase III transcription (GO:0006386)2.95884629
105UTP metabolic process (GO:0046051)2.95735711
106cellular respiration (GO:0045333)2.94292751
107DNA damage response, detection of DNA damage (GO:0042769)2.92127925
108negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.91751205
109positive regulation of ligase activity (GO:0051351)2.90531613
110protein targeting (GO:0006605)2.89837484
111pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.87306849
112establishment of integrated proviral latency (GO:0075713)2.86976391
113aldehyde catabolic process (GO:0046185)2.85507883
114regulation of cellular amino acid metabolic process (GO:0006521)2.83603412
115mitochondrion morphogenesis (GO:0070584)2.83566834
116guanosine-containing compound biosynthetic process (GO:1901070)2.82417568
117regulation of acyl-CoA biosynthetic process (GO:0050812)2.78184810
118ribonucleoside monophosphate biosynthetic process (GO:0009156)2.75758150
119translational initiation (GO:0006413)2.75496910
120maturation of SSU-rRNA (GO:0030490)2.72842999
121negative regulation of protein localization to cell surface (GO:2000009)2.68938826
122nucleoside diphosphate phosphorylation (GO:0006165)2.67950537
123succinate metabolic process (GO:0006105)2.66816629
124positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.64051737
125cellular component biogenesis (GO:0044085)2.62204242
126L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.62106028
127dopamine biosynthetic process (GO:0042416)2.61200754
128protein-cofactor linkage (GO:0018065)2.60805105
129nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.60584682
130cellular ketone body metabolic process (GO:0046950)2.59341323
131CTP metabolic process (GO:0046036)2.57565648
132CTP biosynthetic process (GO:0006241)2.57565648
133ribonucleoside biosynthetic process (GO:0042455)2.56574814
134actin-myosin filament sliding (GO:0033275)2.56521314
135muscle filament sliding (GO:0030049)2.56521314
136nucleoside monophosphate biosynthetic process (GO:0009124)2.56020061
137regulation of cofactor metabolic process (GO:0051193)2.54414616
138regulation of coenzyme metabolic process (GO:0051196)2.54414616
139mitochondrial ATP synthesis coupled proton transport (GO:0042776)11.2291346
140energy coupled proton transport, down electrochemical gradient (GO:0015985)10.4667675
141ATP synthesis coupled proton transport (GO:0015986)10.4667675

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.38638384
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.53574058
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.23220510
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.54375518
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.52496145
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.33874028
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.16802838
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.07525217
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.92497827
10EZH2_22144423_ChIP-Seq_EOC_Human2.90695040
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.83968255
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.79164750
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78755649
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.69326554
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50733819
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.28782180
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.27504777
18VDR_22108803_ChIP-Seq_LS180_Human2.22078916
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.14748335
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09090044
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.08530428
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.05272944
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04687840
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.93271341
25YY1_21170310_ChIP-Seq_MESCs_Mouse1.84548289
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.81786013
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78256766
28TAF15_26573619_Chip-Seq_HEK293_Human1.73040225
29* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.72021148
30DCP1A_22483619_ChIP-Seq_HELA_Human1.71227199
31ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61550377
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57271700
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51962346
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47647367
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45447949
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43991177
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43412697
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42863283
39VDR_23849224_ChIP-Seq_CD4+_Human1.41986691
40ELK1_22589737_ChIP-Seq_MCF10A_Human1.41139952
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38291390
42GBX2_23144817_ChIP-Seq_PC3_Human1.35734006
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34481315
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33961567
45EWS_26573619_Chip-Seq_HEK293_Human1.31086904
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27974714
47ZNF274_21170338_ChIP-Seq_K562_Hela1.26011752
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24590764
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23876863
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23739481
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23707969
52ELK1_19687146_ChIP-ChIP_HELA_Human1.22253369
53FUS_26573619_Chip-Seq_HEK293_Human1.21335709
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20128337
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18169822
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17518291
57TTF2_22483619_ChIP-Seq_HELA_Human1.16420481
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15879398
59XRN2_22483619_ChIP-Seq_HELA_Human1.15364959
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14237019
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.14077354
62* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13200410
63CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11867061
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11160465
65SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11136017
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09720387
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09719398
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09685502
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09623102
70IRF1_19129219_ChIP-ChIP_H3396_Human1.07842445
71HTT_18923047_ChIP-ChIP_STHdh_Human1.07210211
72ER_23166858_ChIP-Seq_MCF-7_Human1.06962419
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.06823901
74FOXP3_21729870_ChIP-Seq_TREG_Human1.06702562
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06252748
76TP53_22573176_ChIP-Seq_HFKS_Human1.05991427
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.05953553
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02317426
79IGF1R_20145208_ChIP-Seq_DFB_Human1.00681771
80CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99525348
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98707903
82MYC_18940864_ChIP-ChIP_HL60_Human0.98405495
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96122997
84PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95785398
85CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94040372
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93449615
87SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93274253
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91038951
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90795085
90SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90093966
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.90085435
92CBX2_27304074_Chip-Seq_ESCs_Mouse0.90017708
93FLI1_27457419_Chip-Seq_LIVER_Mouse0.89961519
94* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88613185
95EED_16625203_ChIP-ChIP_MESCs_Mouse0.84487916
96PCGF2_27294783_Chip-Seq_ESCs_Mouse0.83622043
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83282015
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83169327
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82958373
100JARID2_20075857_ChIP-Seq_MESCs_Mouse0.82732106
101ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82209933
102STAT1_20625510_ChIP-Seq_HELA_Human0.82134289
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82039628
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81867578
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.81638743
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81379669
107GABP_19822575_ChIP-Seq_HepG2_Human0.81328515
108ERG_20517297_ChIP-Seq_VCAP_Human0.81224551
109NANOG_20526341_ChIP-Seq_ESCs_Human0.80348077
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80026791
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.79765872
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79452552
113POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78509904
114NANOG_18555785_ChIP-Seq_MESCs_Mouse0.78227081
115FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77389245
116FOXA1_25329375_ChIP-Seq_VCAP_Human0.77389245
117FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.77210409
118KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77199146
119P300_19829295_ChIP-Seq_ESCs_Human0.77033718
120KDM5A_27292631_Chip-Seq_BREAST_Human0.77008425
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76934108
122TOP2B_26459242_ChIP-Seq_MCF-7_Human0.75785057
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.75320214
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74962749
125ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.74866485
126MYCN_18555785_ChIP-Seq_MESCs_Mouse0.74682365
127MYC_19829295_ChIP-Seq_ESCs_Human0.74425250
128PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.74317825
129AR_20517297_ChIP-Seq_VCAP_Human0.74017057
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.73152167
131SOX2_19829295_ChIP-Seq_ESCs_Human0.72971764
132NANOG_19829295_ChIP-Seq_ESCs_Human0.72971764
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.72789358
134CDX2_19796622_ChIP-Seq_MESCs_Mouse0.72360958
135E2F1_21310950_ChIP-Seq_MCF-7_Human0.72075784
136PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.72016550
137NCOR_22424771_ChIP-Seq_293T_Human0.71854371
138RAD21_21589869_ChIP-Seq_MESCs_Mouse0.71341389
139SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.69558098

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.71169924
2MP0009379_abnormal_foot_pigmentation3.79182549
3MP0001529_abnormal_vocalization3.46333173
4MP0003880_abnormal_central_pattern3.44127156
5MP0006292_abnormal_olfactory_placode3.09465699
6MP0006036_abnormal_mitochondrial_physio3.03381343
7MP0003646_muscle_fatigue3.03238012
8MP0001905_abnormal_dopamine_level2.65543791
9MP0004215_abnormal_myocardial_fiber2.63709464
10MP0000751_myopathy2.55589700
11MP0002938_white_spotting2.54504585
12MP0004036_abnormal_muscle_relaxation2.46536947
13MP0003806_abnormal_nucleotide_metabolis2.40289577
14MP0000749_muscle_degeneration2.36076206
15MP0006035_abnormal_mitochondrial_morpho2.34070174
16MP0006276_abnormal_autonomic_nervous2.31988186
17MP0004084_abnormal_cardiac_muscle2.31378977
18MP0005330_cardiomyopathy2.13474330
19MP0008058_abnormal_DNA_repair2.08985118
20MP0002736_abnormal_nociception_after1.98756329
21MP0003137_abnormal_impulse_conducting1.95813961
22MP0003136_yellow_coat_color1.92154561
23MP0004142_abnormal_muscle_tone1.80714352
24MP0001440_abnormal_grooming_behavior1.78535153
25MP0002277_abnormal_respiratory_mucosa1.75545085
26MP0004145_abnormal_muscle_electrophysio1.70986730
27MP0010030_abnormal_orbit_morphology1.69402635
28MP0001968_abnormal_touch/_nociception1.68968602
29MP0008995_early_reproductive_senescence1.66142073
30MP0001984_abnormal_olfaction1.63450555
31MP0005084_abnormal_gallbladder_morpholo1.62416947
32MP0008789_abnormal_olfactory_epithelium1.61975709
33MP0002972_abnormal_cardiac_muscle1.59146068
34MP0002822_catalepsy1.58464064
35MP0002272_abnormal_nervous_system1.56767277
36MP0003693_abnormal_embryo_hatching1.56353979
37MP0004957_abnormal_blastocyst_morpholog1.55699444
38MP0003186_abnormal_redox_activity1.53426227
39MP0004043_abnormal_pH_regulation1.53370277
40MP0009745_abnormal_behavioral_response1.51492231
41MP0003950_abnormal_plasma_membrane1.50665776
42MP0004484_altered_response_of1.50532495
43MP0005620_abnormal_muscle_contractility1.50417725
44MP0002064_seizures1.49818033
45MP0009046_muscle_twitch1.48116523
46MP0001293_anophthalmia1.44671983
47MP0002332_abnormal_exercise_endurance1.40051764
48MP0002102_abnormal_ear_morphology1.38770834
49MP0008877_abnormal_DNA_methylation1.38334362
50MP0001485_abnormal_pinna_reflex1.36957362
51MP0000750_abnormal_muscle_regeneration1.35023643
52MP0000631_abnormal_neuroendocrine_gland1.31967227
53MP0004924_abnormal_behavior1.31052881
54MP0005386_behavior/neurological_phenoty1.31052881
55MP0005451_abnormal_body_composition1.30270580
56MP0002735_abnormal_chemical_nociception1.29803637
57MP0005171_absent_coat_pigmentation1.29686930
58MP0002653_abnormal_ependyma_morphology1.28784093
59MP0002106_abnormal_muscle_physiology1.27816791
60MP0003786_premature_aging1.27188543
61MP0003195_calcinosis1.25415851
62MP0002163_abnormal_gland_morphology1.25024137
63MP0000747_muscle_weakness1.23533565
64MP0004085_abnormal_heartbeat1.22274511
65MP0000920_abnormal_myelination1.21290166
66MP0002734_abnormal_mechanical_nocicepti1.19834392
67MP0008775_abnormal_heart_ventricle1.19279876
68MP0001727_abnormal_embryo_implantation1.19268326
69MP0005253_abnormal_eye_physiology1.18051761
70MP0005408_hypopigmentation1.17918988
71MP0002572_abnormal_emotion/affect_behav1.17471624
72MP0000566_synostosis1.16794815
73MP0001970_abnormal_pain_threshold1.16761688
74MP0005409_darkened_coat_color1.16525614
75MP0008872_abnormal_physiological_respon1.16010435
76MP0002876_abnormal_thyroid_physiology1.14170180
77MP0001486_abnormal_startle_reflex1.13668180
78MP0004270_analgesia1.12774744
79MP0006138_congestive_heart_failure1.12203792
80MP0005332_abnormal_amino_acid1.11880323
81MP0004133_heterotaxia1.11378868
82MP0002234_abnormal_pharynx_morphology1.10741316
83MP0003635_abnormal_synaptic_transmissio1.10593152
84MP0003121_genomic_imprinting1.10430371
85MP0005385_cardiovascular_system_phenoty1.09739294
86MP0001544_abnormal_cardiovascular_syste1.09739294
87MP0002160_abnormal_reproductive_system1.08747620
88MP0003122_maternal_imprinting1.08572451
89MP0005369_muscle_phenotype1.08223358
90MP0004087_abnormal_muscle_fiber1.07419320
91MP0005535_abnormal_body_temperature1.07251357
92MP0003938_abnormal_ear_development1.06276077
93MP0002067_abnormal_sensory_capabilities1.06144615
94MP0002638_abnormal_pupillary_reflex1.05904226
95MP0005379_endocrine/exocrine_gland_phen1.05666568
96MP0005266_abnormal_metabolism1.05511354
97MP0010386_abnormal_urinary_bladder1.05031213
98MP0005394_taste/olfaction_phenotype1.03146542
99MP0005499_abnormal_olfactory_system1.03146542
100MP0001501_abnormal_sleep_pattern1.02595745
101MP0009697_abnormal_copulation1.02354335
102MP0008875_abnormal_xenobiotic_pharmacok1.02310352
103MP0004147_increased_porphyrin_level1.02018457
104MP0010094_abnormal_chromosome_stability1.01474244
105MP0003787_abnormal_imprinting1.01349056
106MP0003123_paternal_imprinting1.00970082
107MP0002733_abnormal_thermal_nociception1.00928885
108MP0003718_maternal_effect1.00690519
109MP0008932_abnormal_embryonic_tissue0.98525193
110MP0005636_abnormal_mineral_homeostasis0.97592312
111MP0005423_abnormal_somatic_nervous0.97281593
112MP0000049_abnormal_middle_ear0.96862942
113MP0000372_irregular_coat_pigmentation0.96315365
114MP0008004_abnormal_stomach_pH0.95119585
115MP0002095_abnormal_skin_pigmentation0.94332750
116MP0000230_abnormal_systemic_arterial0.93598382
117MP0003077_abnormal_cell_cycle0.93225973
118MP0005646_abnormal_pituitary_gland0.92233894
119MP0005083_abnormal_biliary_tract0.92194982
120MP0005085_abnormal_gallbladder_physiolo0.92036636
121MP0003011_delayed_dark_adaptation0.91824369
122MP0003329_amyloid_beta_deposits0.91075236
123MP0004742_abnormal_vestibular_system0.90134678
124MP0003567_abnormal_fetal_cardiomyocyte0.90073964
125MP0005551_abnormal_eye_electrophysiolog0.87692971
126MP0002127_abnormal_cardiovascular_syste0.86937221
127MP0001664_abnormal_digestion0.86795437
128MP0005389_reproductive_system_phenotype0.86593099
129MP0005645_abnormal_hypothalamus_physiol0.85757542
130MP0000759_abnormal_skeletal_muscle0.84490768
131MP0002210_abnormal_sex_determination0.84378359
132MP0002063_abnormal_learning/memory/cond0.83693132
133MP0002229_neurodegeneration0.83362217
134MP0000026_abnormal_inner_ear0.83055173
135MP0006072_abnormal_retinal_apoptosis0.82667826
136MP0003941_abnormal_skin_development0.80927514
137MP0003221_abnormal_cardiomyocyte_apopto0.79894031
138MP0004381_abnormal_hair_follicle0.79715373
139MP0002269_muscular_atrophy0.79349506
140MP0002752_abnormal_somatic_nervous0.79124766
141MP0002139_abnormal_hepatobiliary_system0.79061804
142MP0005195_abnormal_posterior_eye0.78961169
143MP0005075_abnormal_melanosome_morpholog0.78948230
144MP0002751_abnormal_autonomic_nervous0.78641732
145MP0001764_abnormal_homeostasis0.78631164
146MP0005376_homeostasis/metabolism_phenot0.78437609
147MP0005165_increased_susceptibility_to0.77899388
148MP0003315_abnormal_perineum_morphology0.77871221
149MP0001188_hyperpigmentation0.76801871
150MP0001919_abnormal_reproductive_system0.76459323
151MP0002557_abnormal_social/conspecific_i0.76330139
152MP0005377_hearing/vestibular/ear_phenot0.71865967

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.56609937
2Abnormal mitochondria in muscle tissue (HP:0008316)6.98671334
3Mitochondrial inheritance (HP:0001427)6.66348024
4Acute encephalopathy (HP:0006846)6.44904986
5Progressive macrocephaly (HP:0004481)6.39440092
6Increased CSF lactate (HP:0002490)5.77824248
7Hepatocellular necrosis (HP:0001404)5.65742000
8Increased hepatocellular lipid droplets (HP:0006565)5.36019310
9Hepatic necrosis (HP:0002605)5.27170609
10Lipid accumulation in hepatocytes (HP:0006561)5.02158904
11Cerebral edema (HP:0002181)4.89775712
12Renal Fanconi syndrome (HP:0001994)4.59912221
13Increased intramyocellular lipid droplets (HP:0012240)4.57506732
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.48247823
15Increased serum pyruvate (HP:0003542)4.33531721
16Abnormality of glycolysis (HP:0004366)4.33531721
17Increased muscle lipid content (HP:0009058)4.15548189
18Respiratory failure (HP:0002878)4.14677721
19Exercise intolerance (HP:0003546)4.13409547
20Decreased activity of mitochondrial respiratory chain (HP:0008972)4.09672049
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.09672049
22Lactic acidosis (HP:0003128)4.06665568
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.96787579
243-Methylglutaconic aciduria (HP:0003535)3.90370477
25Leukodystrophy (HP:0002415)3.84620265
26Optic disc pallor (HP:0000543)3.83252821
27Increased serum lactate (HP:0002151)3.71692435
28Exertional dyspnea (HP:0002875)3.44224823
29Congenital, generalized hypertrichosis (HP:0004540)3.09556882
30Muscle hypertrophy of the lower extremities (HP:0008968)3.08495860
31Abnormality of renal resorption (HP:0011038)3.07834761
32Respiratory difficulties (HP:0002880)3.03666739
33Calf muscle hypertrophy (HP:0008981)2.94554237
34Sudden death (HP:0001699)2.89224435
35Abnormality of urine glucose concentration (HP:0011016)2.88703512
36Glycosuria (HP:0003076)2.88703512
37Pheochromocytoma (HP:0002666)2.83553632
38Lethargy (HP:0001254)2.82974437
39Pallor (HP:0000980)2.82658939
40Neuroendocrine neoplasm (HP:0100634)2.79304251
41CNS demyelination (HP:0007305)2.75606009
42Abnormality of cells of the erythroid lineage (HP:0012130)2.74596935
43Aplastic anemia (HP:0001915)2.72359649
44Pancreatic cysts (HP:0001737)2.58983434
45Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.57407695
46Hyperphosphaturia (HP:0003109)2.55942191
47X-linked dominant inheritance (HP:0001423)2.55284328
48Pancreatic fibrosis (HP:0100732)2.52826339
49Emotional lability (HP:0000712)2.45214292
50Septo-optic dysplasia (HP:0100842)2.44364410
51Molar tooth sign on MRI (HP:0002419)2.43581787
52Abnormality of midbrain morphology (HP:0002418)2.43581787
53Abnormal number of erythroid precursors (HP:0012131)2.38966566
54Palpitations (HP:0001962)2.36867277
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31474446
56Dicarboxylic aciduria (HP:0003215)2.31474446
57Oral leukoplakia (HP:0002745)2.30835298
58True hermaphroditism (HP:0010459)2.30767693
59Macrocytic anemia (HP:0001972)2.26225547
60Aplasia/Hypoplasia of the sacrum (HP:0008517)2.21948638
61Parakeratosis (HP:0001036)2.18054995
62Colon cancer (HP:0003003)2.17785593
63Type I transferrin isoform profile (HP:0003642)2.16476106
64Myokymia (HP:0002411)2.16362288
65Abnormal urine phosphate concentration (HP:0012599)2.15921766
66Exercise-induced myalgia (HP:0003738)2.13478760
67Vomiting (HP:0002013)2.10249880
68Methylmalonic aciduria (HP:0012120)2.08910911
69Cerebral hemorrhage (HP:0001342)2.06601701
70Conjunctival hamartoma (HP:0100780)2.06102545
71Nephronophthisis (HP:0000090)2.00747565
72Medial flaring of the eyebrow (HP:0010747)2.00662336
73Muscle fiber splitting (HP:0003555)1.99865395
74Hyperglycinemia (HP:0002154)1.98186532
75Myoglobinuria (HP:0002913)1.97716720
76Rhabdomyolysis (HP:0003201)1.97350774
77Myotonia (HP:0002486)1.96735508
78Abnormality of the anterior horn cell (HP:0006802)1.96368562
79Degeneration of anterior horn cells (HP:0002398)1.96368562
80Ragged-red muscle fibers (HP:0003200)1.95417784
81Sclerocornea (HP:0000647)1.94842111
82Amniotic constriction ring (HP:0009775)1.94123071
83Abnormality of placental membranes (HP:0011409)1.94123071
84Ventricular tachycardia (HP:0004756)1.92997893
85Exercise-induced muscle cramps (HP:0003710)1.92945404
86Hyperalaninemia (HP:0003348)1.92260729
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92260729
88Abnormality of alanine metabolism (HP:0010916)1.92260729
89Renal tubular dysfunction (HP:0000124)1.91668992
90Ventricular fibrillation (HP:0001663)1.91245737
91Methylmalonic acidemia (HP:0002912)1.90635178
92Abnormality of the calf musculature (HP:0001430)1.90584914
93Muscle stiffness (HP:0003552)1.88095846
94Abnormality of methionine metabolism (HP:0010901)1.87929562
95Congenital ichthyosiform erythroderma (HP:0007431)1.85477457
96Abnormal pupillary function (HP:0007686)1.84997513
97Abnormality of the labia minora (HP:0012880)1.84344794
98Microvesicular hepatic steatosis (HP:0001414)1.82611169
99Absent thumb (HP:0009777)1.82608194
100Syncope (HP:0001279)1.82261695
101Absent septum pellucidum (HP:0001331)1.82007240
102Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80433415
103Gliosis (HP:0002171)1.80407623
104Sensory axonal neuropathy (HP:0003390)1.79784187
105Progressive external ophthalmoplegia (HP:0000590)1.76410601
106Pancytopenia (HP:0001876)1.74760618
107Blindness (HP:0000618)1.74757516
108Reticulocytopenia (HP:0001896)1.74516810
109Abnormality of serum amino acid levels (HP:0003112)1.74446094
110Abnormal hemoglobin (HP:0011902)1.74058587
111Cerebral hypomyelination (HP:0006808)1.71981659
112Prolonged QT interval (HP:0001657)1.70944312
113Hypoplastic left heart (HP:0004383)1.70084700
114Abnormality of fatty-acid metabolism (HP:0004359)1.65261267
115Ileus (HP:0002595)1.64925937
116Male pseudohermaphroditism (HP:0000037)1.64164723
117Lipoatrophy (HP:0100578)1.63104379
118Hypothermia (HP:0002045)1.62962297
119Generalized aminoaciduria (HP:0002909)1.61955982
120Athetosis (HP:0002305)1.61270959
121Stenosis of the external auditory canal (HP:0000402)1.60550409
122Atrial fibrillation (HP:0005110)1.59807592
123Delusions (HP:0000746)1.59686053
124Testicular atrophy (HP:0000029)1.58727894
125Metabolic acidosis (HP:0001942)1.57963543
126Optic nerve hypoplasia (HP:0000609)1.57213558
127Abnormal glycosylation (HP:0012345)1.57149958
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.57149958
129Abnormal protein N-linked glycosylation (HP:0012347)1.57149958
130Abnormal protein glycosylation (HP:0012346)1.57149958
131Dilated cardiomyopathy (HP:0001644)1.57068848
132Limb dystonia (HP:0002451)1.56647296
133Hyperglycinuria (HP:0003108)1.56481106
134Rib fusion (HP:0000902)1.56106523
135Megaloblastic anemia (HP:0001889)1.55732835
136Congenital malformation of the right heart (HP:0011723)1.55623338
137Double outlet right ventricle (HP:0001719)1.55623338
138Gait imbalance (HP:0002141)1.55341551
139Anencephaly (HP:0002323)1.54549491
140Nausea (HP:0002018)1.54492498
141Pendular nystagmus (HP:0012043)1.53333364
142Hypoglycemic coma (HP:0001325)1.53270725
143Depressed nasal ridge (HP:0000457)1.53261295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.40358201
2NME13.99058082
3STK393.46603191
4NME23.19877816
5MYLK3.07627482
6PBK2.87301070
7OBSCN2.64281765
8MAP3K122.62948742
9STK162.39806683
10CDC72.37841596
11OXSR12.33592990
12ARAF2.27196121
13WNK42.26008251
14GRK72.22768291
15MUSK2.18500654
16PNCK2.08594818
17MST42.00986020
18LMTK21.98616263
19BCKDK1.98032031
20CASK1.89690100
21NUAK11.80463088
22BUB11.73399794
23GRK51.71844271
24TAF11.68299796
25TLK11.60163796
26CDK191.58918875
27NEK11.56080454
28PHKG21.52136859
29PHKG11.52136859
30MAPKAPK51.52012995
31MAP4K21.49706570
32PLK31.45689117
33LIMK11.42438773
34PDK31.40669048
35PDK41.40669048
36VRK11.34529368
37CAMK2D1.33729445
38EIF2AK11.31510114
39PIK3CA1.29607244
40BCR1.27004088
41MST1R1.26396525
42PLK41.20050653
43EPHA41.19821901
44CAMK2B1.16796017
45ADRBK21.15828626
46CAMK2A1.09221944
47ABL21.06954214
48PDK21.04719742
49BMPR1B1.03494229
50CAMK2G1.02336117
51FGR1.02057516
52INSRR1.01832343
53PINK10.99727585
54PKN10.99209136
55CDK80.96760065
56PLK10.96251380
57TNIK0.95083577
58BRAF0.94069263
59TTK0.93637852
60EIF2AK30.89755353
61CCNB10.89673267
62MAP2K70.89401558
63ROCK20.88682823
64AURKB0.88310470
65BMPR20.87644050
66CSNK1G20.86989133
67DYRK30.85021962
68ILK0.84918086
69WEE10.80409572
70DAPK30.79714738
71CSNK1G10.79153784
72ADRBK10.77895311
73PLK20.77318312
74PIM20.74238594
75EPHB20.71738325
76BRSK20.71513225
77TRIM280.70887069
78CHEK20.69257834
79PRKACA0.69127468
80STK38L0.67581075
81CSNK1G30.66867154
82DYRK20.65278140
83PRKCE0.64911698
84RIPK40.62864369
85MET0.62794477
86MAP3K40.61989458
87TTN0.60899418
88UHMK10.60720949
89MAP2K40.59302485
90ZAK0.58618160
91WNK30.58293515
92MAPK120.57934360
93TIE10.57162252
94PTK2B0.56743573
95LRRK20.54578999
96MAPK130.52989786
97AURKA0.52413917
98MKNK20.51709443
99PASK0.51537742
100MAP3K110.51253042
101GRK60.50226816
102MARK10.49964776
103CSNK1A1L0.49478666
104BRSK10.48864754
105ATR0.48465699
106MKNK10.47640970
107PAK30.45841628
108STK40.45371971
109RPS6KA50.44432081
110KDR0.42919014
111DAPK10.42802244
112CSNK2A20.42781514
113CSNK1E0.42464434
114CSNK1A10.41462081
115CSNK2A10.41374567
116PRKCG0.41258183
117TESK10.40970614
118PRKCQ0.40902880
119TXK0.40593732
120CDK140.40409447
121SRPK10.40408612
122IRAK30.38577900
123FRK0.38401645
124STK240.38300422
125PRKG10.37612463
126GRK10.37185767
127MAP2K60.36899267
128NTRK30.35476282
129WNK10.34666503
130PAK10.34140454
131TESK20.34080505
132PIK3CG0.33086640
133MINK10.32765070
134PRKACB0.32397016
135ROCK10.31855098
136CDK11A0.31773699

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.60316967
2Parkinsons disease_Homo sapiens_hsa050125.69501210
3Alzheimers disease_Homo sapiens_hsa050104.31816176
4Huntingtons disease_Homo sapiens_hsa050163.95885295
5Ribosome_Homo sapiens_hsa030103.65608903
6* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.58547578
7* Cardiac muscle contraction_Homo sapiens_hsa042603.19251009
8Proteasome_Homo sapiens_hsa030502.80936477
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47364988
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20601939
11Fatty acid elongation_Homo sapiens_hsa000622.09283836
12RNA polymerase_Homo sapiens_hsa030201.93682831
13DNA replication_Homo sapiens_hsa030301.87744882
14Protein export_Homo sapiens_hsa030601.87373892
15Propanoate metabolism_Homo sapiens_hsa006401.74408718
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60594400
17Collecting duct acid secretion_Homo sapiens_hsa049661.60443533
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59180145
19Pyruvate metabolism_Homo sapiens_hsa006201.56967123
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47395668
21Sulfur metabolism_Homo sapiens_hsa009201.39469906
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36669123
23Butanoate metabolism_Homo sapiens_hsa006501.32503170
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28277564
25RNA degradation_Homo sapiens_hsa030181.23370100
26Carbon metabolism_Homo sapiens_hsa012001.21817558
27Fanconi anemia pathway_Homo sapiens_hsa034601.11625215
28Base excision repair_Homo sapiens_hsa034101.08608748
29One carbon pool by folate_Homo sapiens_hsa006701.04789789
30Tyrosine metabolism_Homo sapiens_hsa003501.01128388
31* Metabolic pathways_Homo sapiens_hsa011000.97221780
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96735215
33Pyrimidine metabolism_Homo sapiens_hsa002400.95854456
34Phenylalanine metabolism_Homo sapiens_hsa003600.93723221
35RNA transport_Homo sapiens_hsa030130.92031086
36Vibrio cholerae infection_Homo sapiens_hsa051100.91596467
37Glutathione metabolism_Homo sapiens_hsa004800.91569877
38Steroid biosynthesis_Homo sapiens_hsa001000.88127655
39Fatty acid degradation_Homo sapiens_hsa000710.85826961
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81039888
41Peroxisome_Homo sapiens_hsa041460.80393026
42Fatty acid metabolism_Homo sapiens_hsa012120.79853674
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77203414
44Arginine and proline metabolism_Homo sapiens_hsa003300.75559186
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74847537
46Nicotine addiction_Homo sapiens_hsa050330.73733132
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69749766
48Nitrogen metabolism_Homo sapiens_hsa009100.68927169
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68040232
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67826292
51Histidine metabolism_Homo sapiens_hsa003400.66872129
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.64093641
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63038230
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62775003
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60835233
56Ether lipid metabolism_Homo sapiens_hsa005650.60258355
57beta-Alanine metabolism_Homo sapiens_hsa004100.59975557
58Purine metabolism_Homo sapiens_hsa002300.59814291
59Linoleic acid metabolism_Homo sapiens_hsa005910.57728611
60Arachidonic acid metabolism_Homo sapiens_hsa005900.57490851
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55327379
62Non-homologous end-joining_Homo sapiens_hsa034500.52417882
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.52262892
64Serotonergic synapse_Homo sapiens_hsa047260.51278364
65Chemical carcinogenesis_Homo sapiens_hsa052040.50564484
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48963144
67Folate biosynthesis_Homo sapiens_hsa007900.48629096
68Vitamin digestion and absorption_Homo sapiens_hsa049770.47469101
69Caffeine metabolism_Homo sapiens_hsa002320.45405949
70Synaptic vesicle cycle_Homo sapiens_hsa047210.44905407
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44214219
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.44113032
73Tryptophan metabolism_Homo sapiens_hsa003800.43748313
74Phototransduction_Homo sapiens_hsa047440.43366669
75Taste transduction_Homo sapiens_hsa047420.43028142
76Biosynthesis of amino acids_Homo sapiens_hsa012300.42735733
77Rheumatoid arthritis_Homo sapiens_hsa053230.42471955
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.40501764
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40349260
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39163090
81Fructose and mannose metabolism_Homo sapiens_hsa000510.37843165
82Dilated cardiomyopathy_Homo sapiens_hsa054140.37705306
83Sulfur relay system_Homo sapiens_hsa041220.36719201
84Selenocompound metabolism_Homo sapiens_hsa004500.36621823
85Systemic lupus erythematosus_Homo sapiens_hsa053220.34433691
86Pentose phosphate pathway_Homo sapiens_hsa000300.33667111
87GABAergic synapse_Homo sapiens_hsa047270.33000357
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32866346
89Cell cycle_Homo sapiens_hsa041100.31036343
90Homologous recombination_Homo sapiens_hsa034400.30176427
91Vitamin B6 metabolism_Homo sapiens_hsa007500.29827283
92Calcium signaling pathway_Homo sapiens_hsa040200.26153230
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25430992
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.23956268
95Oocyte meiosis_Homo sapiens_hsa041140.23739554
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22354829
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22240127
98PPAR signaling pathway_Homo sapiens_hsa033200.21995327
99Nucleotide excision repair_Homo sapiens_hsa034200.20913199
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20760751
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.20431629
102Spliceosome_Homo sapiens_hsa030400.20255486
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20175516
104Olfactory transduction_Homo sapiens_hsa047400.20169386
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.19895375
106Retinol metabolism_Homo sapiens_hsa008300.19619992
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18836044
108Amphetamine addiction_Homo sapiens_hsa050310.18550539
109Mineral absorption_Homo sapiens_hsa049780.17944447
110Regulation of autophagy_Homo sapiens_hsa041400.17744260
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17251896
112Basal cell carcinoma_Homo sapiens_hsa052170.17133897
113Morphine addiction_Homo sapiens_hsa050320.16844836
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.16731186
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16038054
116Basal transcription factors_Homo sapiens_hsa030220.13911757
117Mismatch repair_Homo sapiens_hsa034300.13901947
118Glutamatergic synapse_Homo sapiens_hsa047240.13868828
119Salivary secretion_Homo sapiens_hsa049700.13171432
120Gastric acid secretion_Homo sapiens_hsa049710.11995949
121Renin secretion_Homo sapiens_hsa049240.11960213
122Sphingolipid metabolism_Homo sapiens_hsa006000.11959547
123Fat digestion and absorption_Homo sapiens_hsa049750.11521692
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.10386727

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