UQCR11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the smallest known component of the ubiquinol-cytochrome c reductase complex, which forms part of the mitochondrial respiratory chain. The encoded protein may function as a binding factor for the iron-sulfur protein in this complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.56021666
2* respiratory electron transport chain (GO:0022904)8.67758465
3* electron transport chain (GO:0022900)8.44692093
4ATP biosynthetic process (GO:0006754)5.76304072
5oxidative phosphorylation (GO:0006119)5.45136538
6protein complex biogenesis (GO:0070271)5.32734581
7purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.23196933
8purine nucleoside triphosphate biosynthetic process (GO:0009145)5.16163136
9NADH dehydrogenase complex assembly (GO:0010257)5.15387279
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.15387279
11mitochondrial respiratory chain complex I assembly (GO:0032981)5.15387279
12chaperone-mediated protein transport (GO:0072321)5.08615009
13* hydrogen ion transmembrane transport (GO:1902600)5.06878886
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.98277320
15inner mitochondrial membrane organization (GO:0007007)4.94241083
16mitochondrial respiratory chain complex assembly (GO:0033108)4.87173519
17ribonucleoside triphosphate biosynthetic process (GO:0009201)4.58634395
18* proton transport (GO:0015992)4.42811821
19DNA deamination (GO:0045006)4.35461746
20* hydrogen transport (GO:0006818)4.35274315
21transcription elongation from RNA polymerase III promoter (GO:0006385)4.31392881
22termination of RNA polymerase III transcription (GO:0006386)4.31392881
23maturation of SSU-rRNA (GO:0030490)4.29464394
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.27254717
25protein neddylation (GO:0045116)4.04760448
26tricarboxylic acid cycle (GO:0006099)4.03190489
27regulation of oxidative phosphorylation (GO:0002082)3.93082528
28regulation of mitochondrial translation (GO:0070129)3.91745106
29nucleoside triphosphate biosynthetic process (GO:0009142)3.91623992
30viral life cycle (GO:0019058)3.91446873
31regulation of cellular amino acid metabolic process (GO:0006521)3.83934557
32aerobic respiration (GO:0009060)3.83406005
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.83127463
34cellular protein complex disassembly (GO:0043624)3.79036857
35pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.69932187
36ribosomal small subunit biogenesis (GO:0042274)3.66912884
37mitochondrial transport (GO:0006839)3.59201431
38sarcomere organization (GO:0045214)3.57530099
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.52627699
40respiratory chain complex IV assembly (GO:0008535)3.52240505
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.51757726
42negative regulation of ligase activity (GO:0051352)3.51757726
43heart contraction (GO:0060047)3.49744315
44heart process (GO:0003015)3.49744315
45positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.48919899
46translational initiation (GO:0006413)3.47348891
47sequestering of actin monomers (GO:0042989)3.47219802
48quinone biosynthetic process (GO:1901663)3.46627170
49ubiquinone biosynthetic process (GO:0006744)3.46627170
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.45928626
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.45107657
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.44464017
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.44464017
54viral transcription (GO:0019083)3.40103251
55purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.39983471
56purine nucleoside monophosphate biosynthetic process (GO:0009127)3.39983471
57GTP biosynthetic process (GO:0006183)3.37321945
58regulation of cellular respiration (GO:0043457)3.37038728
59cytochrome complex assembly (GO:0017004)3.34918121
60NADH metabolic process (GO:0006734)3.33527169
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.33111892
62intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.32014048
63signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.32014048
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.31731851
65signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.31731851
66signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.31731851
67nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30034425
68negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.27545316
69* generation of precursor metabolites and energy (GO:0006091)3.26180119
70cellular component biogenesis (GO:0044085)3.25919119
71protein targeting to mitochondrion (GO:0006626)3.24772886
72actin-myosin filament sliding (GO:0033275)3.24638453
73muscle filament sliding (GO:0030049)3.24638453
74translational termination (GO:0006415)3.23367690
75establishment of protein localization to mitochondrion (GO:0072655)3.19162883
76platelet dense granule organization (GO:0060155)3.18067846
77ubiquinone metabolic process (GO:0006743)3.17443657
78ribosomal large subunit biogenesis (GO:0042273)3.16584145
79deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.15959667
80dopamine transport (GO:0015872)3.15935730
81signal transduction involved in DNA damage checkpoint (GO:0072422)3.15715540
82signal transduction involved in DNA integrity checkpoint (GO:0072401)3.15715540
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14063924
84energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.12355480
85ATP hydrolysis coupled proton transport (GO:0015991)3.12355480
86pseudouridine synthesis (GO:0001522)3.12024727
87signal transduction involved in cell cycle checkpoint (GO:0072395)3.11207517
88metallo-sulfur cluster assembly (GO:0031163)3.10496738
89iron-sulfur cluster assembly (GO:0016226)3.10496738
90regulation of cell communication by electrical coupling (GO:0010649)3.10349009
91cotranslational protein targeting to membrane (GO:0006613)3.09921880
92protein targeting to membrane (GO:0006612)3.08532472
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.07895500
94regulation of acyl-CoA biosynthetic process (GO:0050812)3.06660589
95protein complex disassembly (GO:0043241)3.06620500
96deoxyribonucleotide catabolic process (GO:0009264)3.06458832
97rRNA modification (GO:0000154)3.05794182
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05769138
99positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04690551
100protein targeting to ER (GO:0045047)3.03662509
101water-soluble vitamin biosynthetic process (GO:0042364)3.03104024
102succinate metabolic process (GO:0006105)3.02615252
103cullin deneddylation (GO:0010388)3.02518502
104base-excision repair, AP site formation (GO:0006285)3.02358080
105cardiac myofibril assembly (GO:0055003)3.02354209
106SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.01806012
107regulation of relaxation of muscle (GO:1901077)3.01691446
108cellular respiration (GO:0045333)3.01195149
109protein localization to mitochondrion (GO:0070585)3.00817252
110protein deneddylation (GO:0000338)3.00479437
111regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.96851880
112substantia nigra development (GO:0021762)2.96690821
113pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96364622
114purine nucleoside biosynthetic process (GO:0042451)2.95070948
115purine ribonucleoside biosynthetic process (GO:0046129)2.95070948
116regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.94291336
117myofibril assembly (GO:0030239)2.93879339
118pyrimidine nucleotide catabolic process (GO:0006244)2.93853169
119protein localization to endoplasmic reticulum (GO:0070972)2.93537266
120macromolecular complex disassembly (GO:0032984)2.93274827
121deoxyribose phosphate catabolic process (GO:0046386)2.93185152
122establishment of protein localization to endoplasmic reticulum (GO:0072599)2.92613197
123intracellular protein transmembrane import (GO:0044743)2.92546592
124ribosomal small subunit assembly (GO:0000028)2.87398814
125negative regulation of protein localization to cell surface (GO:2000009)2.85446285
126regulation of actin filament-based movement (GO:1903115)2.84857658
127cardiac muscle tissue morphogenesis (GO:0055008)2.83670140
128regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.82943576
129regulation of coenzyme metabolic process (GO:0051196)2.79634966
130regulation of cofactor metabolic process (GO:0051193)2.79634966
131cardiac muscle contraction (GO:0060048)2.76892766
132cellular response to epinephrine stimulus (GO:0071872)2.73095582
133UTP biosynthetic process (GO:0006228)2.73021972
134cellular ketone body metabolic process (GO:0046950)2.72976312
135ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.72155198
136response to epinephrine (GO:0071871)2.69311605
137translational elongation (GO:0006414)2.68452994
138aldehyde catabolic process (GO:0046185)2.67467940
139proteasome assembly (GO:0043248)2.67177325
140fatty acid elongation (GO:0030497)2.66834689
141calcium-mediated signaling using intracellular calcium source (GO:0035584)2.66697522
142ribonucleoside monophosphate biosynthetic process (GO:0009156)2.66610957
143regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.64608527
144actin-mediated cell contraction (GO:0070252)2.60533482
145protein-cofactor linkage (GO:0018065)2.57744137
146translation (GO:0006412)2.57155168
147mitochondrion morphogenesis (GO:0070584)2.55688623
148regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.54823003
149sarcoplasmic reticulum calcium ion transport (GO:0070296)2.54126384
150mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.7735187
151ATP synthesis coupled proton transport (GO:0015986)10.1004981
152energy coupled proton transport, down electrochemical gradient (GO:0015985)10.1004981

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.93974547
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79563913
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.59675089
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.45442336
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.36249011
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.28903975
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.14111906
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.12826519
9EZH2_22144423_ChIP-Seq_EOC_Human3.00090529
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.87730879
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.86774359
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.86156237
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57405088
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51997740
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.46629080
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38640457
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.31687759
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31208042
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.30237344
20FOXP3_21729870_ChIP-Seq_TREG_Human2.19360718
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.15014271
22VDR_22108803_ChIP-Seq_LS180_Human2.14477762
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11036802
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.07616249
25GABP_19822575_ChIP-Seq_HepG2_Human1.86803576
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84180368
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.82371059
28XRN2_22483619_ChIP-Seq_HELA_Human1.78654894
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77708133
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.70258680
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67876360
32GBX2_23144817_ChIP-Seq_PC3_Human1.67175306
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63714535
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61157187
35TAF15_26573619_Chip-Seq_HEK293_Human1.59448487
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50180089
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50011066
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49506950
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48722741
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48532493
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44404394
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42796639
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40575336
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40037542
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38875727
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.38053745
47* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37264376
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35180469
49DCP1A_22483619_ChIP-Seq_HELA_Human1.34381371
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33480627
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32715119
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31378005
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31195826
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30666008
55HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.29029882
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28726096
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28370607
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.26678950
59* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22787126
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21689402
61JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21525784
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20772590
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.19756488
64IRF1_19129219_ChIP-ChIP_H3396_Human1.18968985
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17328003
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.16533245
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16504701
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15939567
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15587750
70CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14461760
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.13067629
72* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12686454
73PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10210794
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09629353
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08801324
76* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08143021
77YY1_22570637_ChIP-Seq_MALME-3M_Human1.06773567
78TP53_22573176_ChIP-Seq_HFKS_Human1.06203851
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05740196
80FUS_26573619_Chip-Seq_HEK293_Human1.04338661
81* BCL6_27268052_Chip-Seq_Bcells_Human1.03823072
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03181224
83HTT_18923047_ChIP-ChIP_STHdh_Human1.02391002
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02326961
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02253485
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01444703
87VDR_23849224_ChIP-Seq_CD4+_Human1.01329577
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98883278
89CBX2_27304074_Chip-Seq_ESCs_Mouse0.98738233
90FOXP1_21924763_ChIP-Seq_HESCs_Human0.98711431
91CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98412014
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.98182231
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97806136
94STAT1_20625510_ChIP-Seq_HELA_Human0.97130762
95RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96771646
96EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96771646
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96268601
98EZH2_27294783_Chip-Seq_ESCs_Mouse0.96017654
99CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95553447
100SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94908253
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94634209
102MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93954282
103ER_23166858_ChIP-Seq_MCF-7_Human0.93517661
104EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93435512
105CTCF_20526341_ChIP-Seq_ESCs_Human0.93224540
106* CTCF_26484167_Chip-Seq_Bcells_Mouse0.93198002
107ERG_20517297_ChIP-Seq_VCAP_Human0.92985940
108SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92646244
109* TAF2_19829295_ChIP-Seq_ESCs_Human0.91791897
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91719027
111SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90428417
112AR_20517297_ChIP-Seq_VCAP_Human0.90137632
113SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89650060
114ELK1_19687146_ChIP-ChIP_HELA_Human0.89556007
115ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89476911
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88936372
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88663976
118ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88234822
119TTF2_22483619_ChIP-Seq_HELA_Human0.87191584
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86846321
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85686967
122* TET1_21451524_ChIP-Seq_MESCs_Mouse0.85413993
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.83901963
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83527944
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82943957
126MYC_18940864_ChIP-ChIP_HL60_Human0.82937588
127ERA_21632823_ChIP-Seq_H3396_Human0.81628718
128LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.81244981
129IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.80849225
130SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.80755218
131CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.79936873
132SMC3_22415368_ChIP-Seq_MEFs_Mouse0.79624800
133GATA3_21878914_ChIP-Seq_MCF-7_Human0.79358019
134* P300_27268052_Chip-Seq_Bcells_Human0.79097487
135RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.79083862
136* NANOG_20526341_ChIP-Seq_ESCs_Human0.78888831
137PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78707830
138POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78534174
139SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78103382
140SA1_27219007_Chip-Seq_Bcells_Human0.78051056
141RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77789974
142MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.77669679
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.77201642
144YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.76928602
145FOXA1_27270436_Chip-Seq_PROSTATE_Human0.76470564
146FOXA1_25329375_ChIP-Seq_VCAP_Human0.76470564
147EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.76117503
148PADI4_21655091_ChIP-ChIP_MCF-7_Human0.76093534
149P300_19829295_ChIP-Seq_ESCs_Human0.75980885
150TOP2B_26459242_ChIP-Seq_MCF-7_Human0.75694420
151REST_21632747_ChIP-Seq_MESCs_Mouse0.75606685
152ZNF274_21170338_ChIP-Seq_K562_Hela0.75415621
153MYC_19030024_ChIP-ChIP_MESCs_Mouse0.74180967

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.92723604
2MP0003646_muscle_fatigue3.62988759
3MP0004215_abnormal_myocardial_fiber3.19714860
4MP0003880_abnormal_central_pattern3.15922541
5MP0000751_myopathy3.09636684
6MP0001529_abnormal_vocalization3.08852217
7MP0000749_muscle_degeneration3.01506547
8MP0006036_abnormal_mitochondrial_physio2.98918131
9MP0004084_abnormal_cardiac_muscle2.97314573
10MP0004036_abnormal_muscle_relaxation2.91689915
11MP0009379_abnormal_foot_pigmentation2.88145806
12MP0005330_cardiomyopathy2.63263699
13MP0003011_delayed_dark_adaptation2.60374919
14MP0003137_abnormal_impulse_conducting2.27292743
15MP0001905_abnormal_dopamine_level2.20967629
16MP0003806_abnormal_nucleotide_metabolis2.16874828
17MP0005671_abnormal_response_to2.09969700
18MP0006035_abnormal_mitochondrial_morpho2.04397520
19MP0002972_abnormal_cardiac_muscle2.03945206
20MP0004145_abnormal_muscle_electrophysio2.02445180
21MP0003786_premature_aging1.94207550
22MP0002163_abnormal_gland_morphology1.93739055
23MP0006276_abnormal_autonomic_nervous1.91474821
24MP0005620_abnormal_muscle_contractility1.78374950
25MP0005084_abnormal_gallbladder_morpholo1.69758010
26MP0006292_abnormal_olfactory_placode1.66904754
27MP0002653_abnormal_ependyma_morphology1.66393190
28MP0004484_altered_response_of1.66351917
29MP0002277_abnormal_respiratory_mucosa1.62380555
30MP0004085_abnormal_heartbeat1.61200867
31MP0004043_abnormal_pH_regulation1.61118092
32MP0008775_abnormal_heart_ventricle1.59954790
33MP0000750_abnormal_muscle_regeneration1.56728960
34MP0004147_increased_porphyrin_level1.55068935
35MP0002106_abnormal_muscle_physiology1.54261218
36MP0004142_abnormal_muscle_tone1.54021552
37MP0002736_abnormal_nociception_after1.53896914
38MP0003186_abnormal_redox_activity1.52074289
39MP0005645_abnormal_hypothalamus_physiol1.50495889
40MP0002272_abnormal_nervous_system1.50081770
41MP0005451_abnormal_body_composition1.49775378
42MP0003195_calcinosis1.49345039
43MP0001544_abnormal_cardiovascular_syste1.49123993
44MP0005385_cardiovascular_system_phenoty1.49123993
45MP0002332_abnormal_exercise_endurance1.48451343
46MP0002148_abnormal_hypersensitivity_rea1.46053206
47MP0006138_congestive_heart_failure1.45656181
48MP0002822_catalepsy1.43712613
49MP0004087_abnormal_muscle_fiber1.43193383
50MP0008789_abnormal_olfactory_epithelium1.42810636
51MP0009745_abnormal_behavioral_response1.41012871
52MP0001440_abnormal_grooming_behavior1.39414626
53MP0005646_abnormal_pituitary_gland1.38714007
54MP0008058_abnormal_DNA_repair1.35790597
55MP0001968_abnormal_touch/_nociception1.33484107
56MP0000747_muscle_weakness1.33038300
57MP0009785_altered_susceptibility_to1.31511957
58MP0008875_abnormal_xenobiotic_pharmacok1.30678204
59MP0003136_yellow_coat_color1.29733740
60MP0002064_seizures1.28978069
61MP0003718_maternal_effect1.28644928
62MP0005369_muscle_phenotype1.26440630
63MP0005670_abnormal_white_adipose1.26071263
64MP0002735_abnormal_chemical_nociception1.21741092
65MP0003950_abnormal_plasma_membrane1.21493871
66MP0002876_abnormal_thyroid_physiology1.19175164
67MP0004924_abnormal_behavior1.18203751
68MP0005386_behavior/neurological_phenoty1.18203751
69MP0002269_muscular_atrophy1.16745400
70MP0005535_abnormal_body_temperature1.13378947
71MP0009046_muscle_twitch1.13068287
72MP0005266_abnormal_metabolism1.12535886
73MP0009333_abnormal_splenocyte_physiolog1.11424586
74MP0005253_abnormal_eye_physiology1.10216481
75MP0002938_white_spotting1.10054939
76MP0005085_abnormal_gallbladder_physiolo1.09234867
77MP0005075_abnormal_melanosome_morpholog1.08895684
78MP0000230_abnormal_systemic_arterial1.08808546
79MP0008995_early_reproductive_senescence1.08665922
80MP0002095_abnormal_skin_pigmentation1.08317787
81MP0005332_abnormal_amino_acid1.06904929
82MP0003123_paternal_imprinting1.06841172
83MP0002102_abnormal_ear_morphology1.06800989
84MP0000920_abnormal_myelination1.06020970
85MP0003635_abnormal_synaptic_transmissio1.05797652
86MP0001727_abnormal_embryo_implantation1.05415186
87MP0002572_abnormal_emotion/affect_behav1.04869052
88MP0000759_abnormal_skeletal_muscle1.04302849
89MP0005410_abnormal_fertilization1.04106173
90MP0002127_abnormal_cardiovascular_syste0.98124279
91MP0004130_abnormal_muscle_cell0.97298574
92MP0005409_darkened_coat_color0.95969132
93MP0009764_decreased_sensitivity_to0.95900806
94MP0004270_analgesia0.95875319
95MP0005165_increased_susceptibility_to0.95721913
96MP0003221_abnormal_cardiomyocyte_apopto0.94203172
97MP0003329_amyloid_beta_deposits0.93243081
98MP0001853_heart_inflammation0.92416826
99MP0002734_abnormal_mechanical_nocicepti0.91795483
100MP0005636_abnormal_mineral_homeostasis0.91621678
101MP0002067_abnormal_sensory_capabilities0.90749118
102MP0001485_abnormal_pinna_reflex0.90371929
103MP0005389_reproductive_system_phenotype0.89587696
104MP0003828_pulmonary_edema0.89536943
105MP0010386_abnormal_urinary_bladder0.89044724
106MP0001486_abnormal_startle_reflex0.88778026
107MP0001984_abnormal_olfaction0.88606906
108MP0001970_abnormal_pain_threshold0.87234521
109MP0005360_urolithiasis0.86929516
110MP0010630_abnormal_cardiac_muscle0.86908170
111MP0005171_absent_coat_pigmentation0.86735052
112MP0001501_abnormal_sleep_pattern0.86328042
113MP0002139_abnormal_hepatobiliary_system0.86065339
114MP0001542_abnormal_bone_strength0.85481483
115MP0002638_abnormal_pupillary_reflex0.85444726
116MP0002063_abnormal_learning/memory/cond0.84083339
117MP0003638_abnormal_response/metabolism_0.83886960
118MP0002160_abnormal_reproductive_system0.83409600
119MP0001756_abnormal_urination0.83359550
120MP0005464_abnormal_platelet_physiology0.82491908
121MP0005379_endocrine/exocrine_gland_phen0.81000600
122MP0004019_abnormal_vitamin_homeostasis0.80501353
123MP0009697_abnormal_copulation0.79962570
124MP0004133_heterotaxia0.79334253
125MP0000372_irregular_coat_pigmentation0.79333280
126MP0005584_abnormal_enzyme/coenzyme_acti0.79201603
127MP0001919_abnormal_reproductive_system0.78587219
128MP0005083_abnormal_biliary_tract0.78444700
129MP0000013_abnormal_adipose_tissue0.76768744
130MP0009643_abnormal_urine_homeostasis0.76655342
131MP0001986_abnormal_taste_sensitivity0.75890600
132MP0005376_homeostasis/metabolism_phenot0.75424531
133MP0002229_neurodegeneration0.73031294
134MP0002132_abnormal_respiratory_system0.72593977
135MP0001835_abnormal_antigen_presentation0.71614654
136MP0006072_abnormal_retinal_apoptosis0.71581757
137MP0003656_abnormal_erythrocyte_physiolo0.71179194
138MP0008872_abnormal_physiological_respon0.70705159
139MP0002693_abnormal_pancreas_physiology0.70431907
140MP0001764_abnormal_homeostasis0.69864729
141MP0000343_altered_response_to0.69745288
142MP0003878_abnormal_ear_physiology0.69510307
143MP0005377_hearing/vestibular/ear_phenot0.69510307
144MP0002733_abnormal_thermal_nociception0.68997101
145MP0004742_abnormal_vestibular_system0.66965970
146MP0005551_abnormal_eye_electrophysiolog0.66828066
147MP0008873_increased_physiological_sensi0.64126626
148MP0000358_abnormal_cell_content/0.63944546
149MP0005319_abnormal_enzyme/_coenzyme0.63554237
150MP0005365_abnormal_bile_salt0.63489494
151MP0005025_abnormal_response_to0.63358752

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.52929781
2Abnormal mitochondria in muscle tissue (HP:0008316)6.94369715
3Mitochondrial inheritance (HP:0001427)6.66271222
4Acute encephalopathy (HP:0006846)6.44964685
5Progressive macrocephaly (HP:0004481)6.28144086
6Hepatocellular necrosis (HP:0001404)5.99273065
7Increased CSF lactate (HP:0002490)5.77227054
8Hepatic necrosis (HP:0002605)5.60772434
9Increased hepatocellular lipid droplets (HP:0006565)5.09646932
10Cerebral edema (HP:0002181)4.96469564
11Lipid accumulation in hepatocytes (HP:0006561)4.88566985
12Increased intramyocellular lipid droplets (HP:0012240)4.47257562
13Renal Fanconi syndrome (HP:0001994)4.39156307
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.31184840
15Respiratory failure (HP:0002878)4.19860126
16Increased muscle lipid content (HP:0009058)4.18137161
17Exercise intolerance (HP:0003546)4.17358828
18Lactic acidosis (HP:0003128)4.14735473
19Increased serum pyruvate (HP:0003542)3.90099708
20Abnormality of glycolysis (HP:0004366)3.90099708
21Optic disc pallor (HP:0000543)3.87014652
22Sudden death (HP:0001699)3.83699435
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.76784631
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.76784631
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.73291893
26Leukodystrophy (HP:0002415)3.72040483
27Increased serum lactate (HP:0002151)3.61243046
28Calf muscle hypertrophy (HP:0008981)3.54105393
29Muscle hypertrophy of the lower extremities (HP:0008968)3.53496471
303-Methylglutaconic aciduria (HP:0003535)3.37878901
31Exertional dyspnea (HP:0002875)3.23217620
32Respiratory difficulties (HP:0002880)2.96106383
33Ventricular tachycardia (HP:0004756)2.94949734
34Aplastic anemia (HP:0001915)2.93931716
35Abnormality of renal resorption (HP:0011038)2.84824837
36Glycosuria (HP:0003076)2.81050386
37Abnormality of urine glucose concentration (HP:0011016)2.81050386
38Palpitations (HP:0001962)2.79464138
39Lethargy (HP:0001254)2.78598206
40Pheochromocytoma (HP:0002666)2.71975312
41Neuroendocrine neoplasm (HP:0100634)2.71713507
42Abnormality of cells of the erythroid lineage (HP:0012130)2.69882261
43CNS demyelination (HP:0007305)2.65964602
44Reticulocytopenia (HP:0001896)2.61778255
45Type I transferrin isoform profile (HP:0003642)2.55296994
46Exercise-induced myalgia (HP:0003738)2.53388134
47X-linked dominant inheritance (HP:0001423)2.51007209
48Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50596714
49Dicarboxylic aciduria (HP:0003215)2.50596714
50Abnormality of the calf musculature (HP:0001430)2.50245741
51Atrial fibrillation (HP:0005110)2.49530271
52Abnormal number of erythroid precursors (HP:0012131)2.48558672
53Lipoatrophy (HP:0100578)2.48376138
54Hyperphosphaturia (HP:0003109)2.46318324
55Congenital, generalized hypertrichosis (HP:0004540)2.43903139
56Muscle fiber splitting (HP:0003555)2.43401355
57Exercise-induced muscle cramps (HP:0003710)2.41275554
58Supraventricular tachycardia (HP:0004755)2.37722247
59Myoglobinuria (HP:0002913)2.35928683
60Emotional lability (HP:0000712)2.33507542
61Primary atrial arrhythmia (HP:0001692)2.33349603
62Supraventricular arrhythmia (HP:0005115)2.29067366
63Syncope (HP:0001279)2.28573000
64Dilated cardiomyopathy (HP:0001644)2.22461484
65Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.21164670
66Vomiting (HP:0002013)2.19703124
67Conjunctival hamartoma (HP:0100780)2.18247347
68Rhabdomyolysis (HP:0003201)2.18108978
69Molar tooth sign on MRI (HP:0002419)2.17824415
70Abnormality of midbrain morphology (HP:0002418)2.17824415
71Pancreatic fibrosis (HP:0100732)2.16136909
72Pancytopenia (HP:0001876)2.16015422
73Pancreatic cysts (HP:0001737)2.15149574
74Aplasia/Hypoplasia of the sacrum (HP:0008517)2.12001736
75Ketoacidosis (HP:0001993)2.11908781
76Methylmalonic aciduria (HP:0012120)2.10072796
77Abnormal urine phosphate concentration (HP:0012599)2.09105806
78Hyperglycinemia (HP:0002154)2.08302675
79Myotonia (HP:0002486)2.07109730
80Prolonged QT interval (HP:0001657)2.04501813
81Cerebral hemorrhage (HP:0001342)2.03427166
82Abnormality of fatty-acid metabolism (HP:0004359)2.02784631
83Generalized aminoaciduria (HP:0002909)2.01317274
84Ragged-red muscle fibers (HP:0003200)2.00372142
85Methylmalonic acidemia (HP:0002912)1.97189616
86Abnormal protein glycosylation (HP:0012346)1.96448007
87Abnormal glycosylation (HP:0012345)1.96448007
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96448007
89Abnormal protein N-linked glycosylation (HP:0012347)1.96448007
90Oral leukoplakia (HP:0002745)1.94457000
91Testicular atrophy (HP:0000029)1.92063988
92Parakeratosis (HP:0001036)1.89460643
93Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86686174
94Type 2 muscle fiber atrophy (HP:0003554)1.86431253
95Gliosis (HP:0002171)1.85958969
96EMG: myopathic abnormalities (HP:0003458)1.85339355
97Renal tubular dysfunction (HP:0000124)1.83996794
98Macrocytic anemia (HP:0001972)1.83665731
99Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82704950
100True hermaphroditism (HP:0010459)1.82684231
101Pallor (HP:0000980)1.82337019
102Ketosis (HP:0001946)1.81753793
103Opisthotonus (HP:0002179)1.81456211
104Muscle fiber atrophy (HP:0100295)1.80284553
105Muscle stiffness (HP:0003552)1.79882545
106Hypoplastic left heart (HP:0004383)1.78511210
107Hyperalaninemia (HP:0003348)1.77612762
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77612762
109Abnormality of alanine metabolism (HP:0010916)1.77612762
110Metabolic acidosis (HP:0001942)1.77083247
111Myokymia (HP:0002411)1.76549692
112Nausea (HP:0002018)1.74530820
113Progressive external ophthalmoplegia (HP:0000590)1.74016170
114Blindness (HP:0000618)1.73970992
115Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.72488147
116Neoplasm of head and neck (HP:0012288)1.71419263
117Esophageal neoplasm (HP:0100751)1.71419263
118Congenital stationary night blindness (HP:0007642)1.71236710
119Sclerocornea (HP:0000647)1.70509824
120Abnormal pupillary function (HP:0007686)1.70187158
121Left ventricular hypertrophy (HP:0001712)1.70039411
122Microretrognathia (HP:0000308)1.68154001
123Microvesicular hepatic steatosis (HP:0001414)1.68137958
124Progressive microcephaly (HP:0000253)1.68054762
125Cerebral palsy (HP:0100021)1.67022251
126Abnormal rod and cone electroretinograms (HP:0008323)1.65383261
127Double outlet right ventricle (HP:0001719)1.65257738
128Congenital malformation of the right heart (HP:0011723)1.65257738
129Abnormality of the left ventricular outflow tract (HP:0011103)1.64661369
130Subaortic stenosis (HP:0001682)1.64661369
131Abnormality of the anterior horn cell (HP:0006802)1.64283440
132Degeneration of anterior horn cells (HP:0002398)1.64283440
133Hyporeflexia of lower limbs (HP:0002600)1.63080189
134Decreased electroretinogram (ERG) amplitude (HP:0000654)1.61086913
135Reduced antithrombin III activity (HP:0001976)1.58327083
136Abnormality of serum amino acid levels (HP:0003112)1.58145904
137Petechiae (HP:0000967)1.56292089
138Amniotic constriction ring (HP:0009775)1.55358922
139Abnormality of placental membranes (HP:0011409)1.55358922
140Absent thumb (HP:0009777)1.55014172
141Medial flaring of the eyebrow (HP:0010747)1.54972486
142Delayed CNS myelination (HP:0002188)1.51504900

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.52758188
2MYLK4.03004105
3NME13.35436688
4NME23.23999107
5TESK23.22825540
6OBSCN3.08396772
7MUSK3.01302921
8BCKDK2.96158306
9STK392.87107019
10MAP3K122.58465509
11STK162.53050689
12WNK42.39549482
13GRK72.36238656
14TESK12.32061042
15ARAF2.11832315
16OXSR12.04491017
17CASK1.97791531
18TXK1.96505839
19MAP4K21.96467358
20GRK51.77202195
21PHKG11.70695237
22PHKG21.70695237
23PBK1.67559067
24TNIK1.51130733
25PIK3CA1.50287856
26PNCK1.49554517
27CAMK2D1.49039988
28MST41.47554841
29CDK191.42932157
30PDK41.39790045
31PDK31.39790045
32NUAK11.38018061
33TTN1.37722333
34BCR1.33224676
35LMTK21.31719820
36NEK11.29650344
37LIMK11.27758663
38PKN11.26749451
39PINK11.25536246
40BMPR21.21582125
41CAMK2A1.21388914
42MAPKAPK31.20317033
43ILK1.19600936
44VRK11.18255499
45EPHA41.16786114
46CAMK2B1.15900429
47ABL21.14842456
48EIF2AK11.13060126
49BRAF1.12805117
50DAPK31.12517632
51RIPK41.09177794
52MAPKAPK51.03396301
53TAOK31.02921096
54TIE11.01581496
55CAMK2G1.01580405
56ROCK21.01214147
57DAPK11.00702765
58TLK10.98987029
59PTK2B0.95090942
60MAP2K70.94135168
61ADRBK20.93783089
62RPS6KA50.91028813
63ADRBK10.87733818
64PLK20.87618002
65STK240.85648766
66PRKCE0.84909555
67FGR0.83844342
68CAMKK20.83211936
69PDK20.82921142
70LRRK20.82139026
71UHMK10.80572465
72PAK30.80243571
73SRPK10.78539466
74CSNK1G20.77744748
75AURKA0.77310878
76CDC70.77068707
77MAP2K60.76604704
78PRKACA0.71272415
79MAP3K110.71099562
80NTRK30.71007266
81CSNK1G10.70529033
82IKBKB0.68017119
83SCYL20.67120047
84PIM20.65900825
85BUB10.65756754
86FRK0.64204241
87KDR0.61911606
88MAP3K40.61656263
89TAOK20.61064940
90CAMK10.59735885
91ZAK0.58832766
92CSNK1G30.58585979
93MAPK120.57799162
94PIK3CG0.57771624
95MST1R0.56734150
96CCNB10.54962166
97CSNK1A1L0.51851735
98PAK10.51697908
99MAPK150.51542750
100MAP2K40.50942797
101INSRR0.50603082
102PLK10.49950332
103DYRK20.49475843
104EIF2AK30.49251989
105GRK60.48318990
106PRKCG0.47254800
107ROCK10.47142323
108PRKCI0.46307179
109BMPR1B0.42261780
110MAP2K20.41600955
111ITK0.41395146
112AURKB0.41292881
113TEC0.40807747
114SYK0.40254472
115PRKD10.39797220
116PRKCQ0.38778611
117WNK30.37975913
118RAF10.37905560
119PRKACB0.37621179
120STK38L0.36687774
121MINK10.36629280
122IRAK20.36477855
123PLK30.35975224
124PLK40.34960777
125DYRK30.34235331
126CSNK1A10.33824109
127TBK10.33592927
128STK40.33384725
129CDK50.33374976
130CDK80.32627141
131CSNK2A10.32400595
132PRKG10.31827946
133CSNK2A20.31811711
134GRK10.31770544
135LYN0.31425104
136MAPK40.31161604
137MAPK130.29798867
138PRKCA0.29756140
139MAP4K10.28730182
140CDK140.28695157
141TRIM280.28425225
142MARK10.28327884
143PRKCD0.26672391

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.62178226
2Parkinsons disease_Homo sapiens_hsa050125.69256163
3Alzheimers disease_Homo sapiens_hsa050104.38996774
4Huntingtons disease_Homo sapiens_hsa050163.92684913
5* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.67978762
6* Cardiac muscle contraction_Homo sapiens_hsa042603.44741863
7Ribosome_Homo sapiens_hsa030103.07088220
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.86319861
9Proteasome_Homo sapiens_hsa030502.24817892
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07957176
11Propanoate metabolism_Homo sapiens_hsa006402.02346842
12Fatty acid elongation_Homo sapiens_hsa000622.01766743
13Protein export_Homo sapiens_hsa030601.83045254
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76292890
15Pyruvate metabolism_Homo sapiens_hsa006201.72421254
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69865533
17Homologous recombination_Homo sapiens_hsa034401.60469532
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58216383
19Sulfur metabolism_Homo sapiens_hsa009201.56828022
20DNA replication_Homo sapiens_hsa030301.54045644
21Collecting duct acid secretion_Homo sapiens_hsa049661.51957587
22RNA polymerase_Homo sapiens_hsa030201.50517315
23Mismatch repair_Homo sapiens_hsa034301.45368566
24Butanoate metabolism_Homo sapiens_hsa006501.37652281
25Carbon metabolism_Homo sapiens_hsa012001.30539061
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28231165
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20871073
28Fatty acid degradation_Homo sapiens_hsa000711.19531336
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13532410
30Base excision repair_Homo sapiens_hsa034101.13099093
31Nucleotide excision repair_Homo sapiens_hsa034201.06251162
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04889590
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02171599
34One carbon pool by folate_Homo sapiens_hsa006700.99268301
35Phenylalanine metabolism_Homo sapiens_hsa003600.98630224
36Primary immunodeficiency_Homo sapiens_hsa053400.97462927
37Fatty acid metabolism_Homo sapiens_hsa012120.96559637
38Peroxisome_Homo sapiens_hsa041460.95351606
39* Metabolic pathways_Homo sapiens_hsa011000.94616509
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93608193
41Tyrosine metabolism_Homo sapiens_hsa003500.92391510
42Spliceosome_Homo sapiens_hsa030400.84229306
43Glutathione metabolism_Homo sapiens_hsa004800.84005672
44Vibrio cholerae infection_Homo sapiens_hsa051100.83562453
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83167654
46Asthma_Homo sapiens_hsa053100.82512219
47RNA degradation_Homo sapiens_hsa030180.80824870
48Dilated cardiomyopathy_Homo sapiens_hsa054140.80616176
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79737802
50Fanconi anemia pathway_Homo sapiens_hsa034600.75031734
51Arginine and proline metabolism_Homo sapiens_hsa003300.74635874
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73933782
53Pyrimidine metabolism_Homo sapiens_hsa002400.73010080
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72965464
55beta-Alanine metabolism_Homo sapiens_hsa004100.69608500
56Caffeine metabolism_Homo sapiens_hsa002320.66739444
57Autoimmune thyroid disease_Homo sapiens_hsa053200.66583792
58Nicotine addiction_Homo sapiens_hsa050330.66533892
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64933918
60Allograft rejection_Homo sapiens_hsa053300.64078414
61Nitrogen metabolism_Homo sapiens_hsa009100.63082668
62Chemical carcinogenesis_Homo sapiens_hsa052040.61788712
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61492950
64Histidine metabolism_Homo sapiens_hsa003400.58017034
65Graft-versus-host disease_Homo sapiens_hsa053320.56282883
66Sulfur relay system_Homo sapiens_hsa041220.55699957
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.55491691
68Basal transcription factors_Homo sapiens_hsa030220.54717197
69Type I diabetes mellitus_Homo sapiens_hsa049400.54189878
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53938949
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.53866308
72Tryptophan metabolism_Homo sapiens_hsa003800.52992055
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52672818
74Systemic lupus erythematosus_Homo sapiens_hsa053220.52536361
75Steroid biosynthesis_Homo sapiens_hsa001000.52302775
76Purine metabolism_Homo sapiens_hsa002300.51141539
77Biosynthesis of amino acids_Homo sapiens_hsa012300.50974150
78Antigen processing and presentation_Homo sapiens_hsa046120.48657172
79Arachidonic acid metabolism_Homo sapiens_hsa005900.48645253
80Taste transduction_Homo sapiens_hsa047420.48398098
81Serotonergic synapse_Homo sapiens_hsa047260.48060231
82Regulation of autophagy_Homo sapiens_hsa041400.47930846
83Linoleic acid metabolism_Homo sapiens_hsa005910.46154024
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43191413
85Calcium signaling pathway_Homo sapiens_hsa040200.40941483
86PPAR signaling pathway_Homo sapiens_hsa033200.40779290
87Rheumatoid arthritis_Homo sapiens_hsa053230.39179649
88Folate biosynthesis_Homo sapiens_hsa007900.39003752
89Synaptic vesicle cycle_Homo sapiens_hsa047210.38683987
90Ether lipid metabolism_Homo sapiens_hsa005650.38388332
91GABAergic synapse_Homo sapiens_hsa047270.37521181
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37304918
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.36430397
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36316232
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35847331
96Mineral absorption_Homo sapiens_hsa049780.35065980
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34176595
98RNA transport_Homo sapiens_hsa030130.33839564
99Starch and sucrose metabolism_Homo sapiens_hsa005000.32769848
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32540552
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31828832
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31039759
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30636987
104Fructose and mannose metabolism_Homo sapiens_hsa000510.30467806
105Hematopoietic cell lineage_Homo sapiens_hsa046400.28625118
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.28070964
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26948733
108Phototransduction_Homo sapiens_hsa047440.24518536
109N-Glycan biosynthesis_Homo sapiens_hsa005100.24398845
110Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.23944272
111Fat digestion and absorption_Homo sapiens_hsa049750.23874707
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.23757974
113Circadian entrainment_Homo sapiens_hsa047130.23661449
114Morphine addiction_Homo sapiens_hsa050320.23402179
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22712022
116Renin secretion_Homo sapiens_hsa049240.21531786
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.20644873
118Salivary secretion_Homo sapiens_hsa049700.20598027
119Retinol metabolism_Homo sapiens_hsa008300.20399874
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.19465632
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18840097
122Glutamatergic synapse_Homo sapiens_hsa047240.17264106
123Amphetamine addiction_Homo sapiens_hsa050310.14901529
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13660862
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.13256158
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.12054661
127Galactose metabolism_Homo sapiens_hsa000520.11932217
128Arginine biosynthesis_Homo sapiens_hsa002200.11651642
129Pentose phosphate pathway_Homo sapiens_hsa000300.11280971
130Gastric acid secretion_Homo sapiens_hsa049710.09276953
131Dopaminergic synapse_Homo sapiens_hsa047280.07765532
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.07688985
133Long-term potentiation_Homo sapiens_hsa047200.07362516
134Phagosome_Homo sapiens_hsa041450.06999232

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