UQCRB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.61511709
2* respiratory electron transport chain (GO:0022904)8.93376028
3* electron transport chain (GO:0022900)8.69967157
4translational elongation (GO:0006414)6.75183814
5cellular protein complex disassembly (GO:0043624)6.40561603
6viral life cycle (GO:0019058)6.25556899
7nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.11730141
8ribosomal large subunit biogenesis (GO:0042273)6.01316501
9translational initiation (GO:0006413)5.84680978
10ATP biosynthetic process (GO:0006754)5.63662971
11maturation of SSU-rRNA (GO:0030490)5.54542712
12mitochondrial respiratory chain complex I assembly (GO:0032981)5.50888356
13NADH dehydrogenase complex assembly (GO:0010257)5.50888356
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.50888356
15* oxidative phosphorylation (GO:0006119)5.45447200
16protein complex biogenesis (GO:0070271)5.36906667
17protein complex disassembly (GO:0043241)5.34455390
18tricarboxylic acid cycle (GO:0006099)5.32818194
19establishment of protein localization to mitochondrial membrane (GO:0090151)5.21451760
20purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.16338477
21macromolecular complex disassembly (GO:0032984)5.16121983
22purine nucleoside triphosphate biosynthetic process (GO:0009145)5.11986530
23chaperone-mediated protein transport (GO:0072321)5.09281176
24hydrogen ion transmembrane transport (GO:1902600)5.01061418
25protein targeting to membrane (GO:0006612)5.00387887
26mitochondrial respiratory chain complex assembly (GO:0033108)4.90638577
27inner mitochondrial membrane organization (GO:0007007)4.85784013
28ribonucleoside triphosphate biosynthetic process (GO:0009201)4.54461386
29protein neddylation (GO:0045116)4.49425283
30proton transport (GO:0015992)4.46038125
31hydrogen transport (GO:0006818)4.38976726
32regulation of acyl-CoA biosynthetic process (GO:0050812)4.33750986
33ubiquinone biosynthetic process (GO:0006744)4.23726745
34quinone biosynthetic process (GO:1901663)4.23726745
35nuclear-transcribed mRNA catabolic process (GO:0000956)4.21918967
36regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.13193605
37NADH metabolic process (GO:0006734)4.09665385
38regulation of mitochondrial translation (GO:0070129)4.07310120
39regulation of cofactor metabolic process (GO:0051193)4.03355730
40regulation of coenzyme metabolic process (GO:0051196)4.03355730
41mRNA catabolic process (GO:0006402)3.98846117
42nucleoside triphosphate biosynthetic process (GO:0009142)3.97967822
43mitochondrial transport (GO:0006839)3.94127412
44succinate metabolic process (GO:0006105)3.91532074
45* aerobic respiration (GO:0009060)3.85681771
46ubiquinone metabolic process (GO:0006743)3.84782427
47regulation of oxidative phosphorylation (GO:0002082)3.79656631
48proteasome assembly (GO:0043248)3.69715793
49respiratory chain complex IV assembly (GO:0008535)3.66344730
50establishment of protein localization to membrane (GO:0090150)3.60985173
51RNA catabolic process (GO:0006401)3.58328340
52purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.57828311
53purine nucleoside monophosphate biosynthetic process (GO:0009127)3.57828311
54* cellular respiration (GO:0045333)3.55739868
55protein targeting to mitochondrion (GO:0006626)3.53675083
56cellular component biogenesis (GO:0044085)3.53552145
57cytochrome complex assembly (GO:0017004)3.51828675
58GTP biosynthetic process (GO:0006183)3.50702747
59protein targeting (GO:0006605)3.49961942
60regulation of cellular respiration (GO:0043457)3.48255141
61protein localization to mitochondrion (GO:0070585)3.46479080
62establishment of protein localization to mitochondrion (GO:0072655)3.41980890
63ribonucleoprotein complex biogenesis (GO:0022613)3.41930145
64heart process (GO:0003015)3.33965131
65heart contraction (GO:0060047)3.33965131
66cullin deneddylation (GO:0010388)3.33301227
67regulation of cellular amino acid metabolic process (GO:0006521)3.30549102
68* generation of precursor metabolites and energy (GO:0006091)3.26929890
69ATP hydrolysis coupled proton transport (GO:0015991)3.25582565
70energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.25582565
71actin-myosin filament sliding (GO:0033275)3.25027899
72muscle filament sliding (GO:0030049)3.25027899
73establishment of protein localization to organelle (GO:0072594)3.20299240
74branched-chain amino acid catabolic process (GO:0009083)3.18128061
75ribosomal small subunit biogenesis (GO:0042274)3.14571733
76quinone metabolic process (GO:1901661)3.14558563
77regulation of sequestering of triglyceride (GO:0010889)3.10430090
78regulation of sulfur metabolic process (GO:0042762)3.08570419
79purine ribonucleoside biosynthetic process (GO:0046129)3.07029047
80purine nucleoside biosynthetic process (GO:0042451)3.07029047
81spliceosomal complex assembly (GO:0000245)3.05377934
82protein-cofactor linkage (GO:0018065)3.05266545
83intracellular protein transmembrane import (GO:0044743)3.03883687
84cotranslational protein targeting to membrane (GO:0006613)3.03687711
85organelle disassembly (GO:1903008)3.02364778
86protein deneddylation (GO:0000338)3.00706100
87regulation of cell communication by electrical coupling (GO:0010649)2.98514235
88protein localization to membrane (GO:0072657)2.97938523
89protein targeting to ER (GO:0045047)2.97247016
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.97017378
91ribonucleoside monophosphate biosynthetic process (GO:0009156)2.96967264
92SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.96722154
93aldehyde catabolic process (GO:0046185)2.96435145
94dopamine transport (GO:0015872)2.94914028
95negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.94848486
96viral transcription (GO:0019083)2.94518270
97protein localization to endoplasmic reticulum (GO:0070972)2.91152732
98translational termination (GO:0006415)2.87271498
99ribosomal small subunit assembly (GO:0000028)2.87146170
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86898352
101establishment of protein localization to endoplasmic reticulum (GO:0072599)2.84595789
102translation (GO:0006412)2.83048950
103establishment of integrated proviral latency (GO:0075713)2.80250807
104DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.79438455
105UTP biosynthetic process (GO:0006228)2.79302323
106transcription elongation from RNA polymerase III promoter (GO:0006385)2.78657195
107termination of RNA polymerase III transcription (GO:0006386)2.78657195
108L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.77719577
109nucleoside monophosphate biosynthetic process (GO:0009124)2.77460290
110guanosine-containing compound biosynthetic process (GO:1901070)2.76721085
111antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.76559955
112ribonucleoprotein complex disassembly (GO:0032988)2.75954355
113positive regulation of mitochondrial fission (GO:0090141)2.73601064
114oxaloacetate metabolic process (GO:0006107)2.73058057
115regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.72814058
116signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.72411683
117intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.72411683
118nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.70518143
119ribonucleoside biosynthetic process (GO:0042455)2.67922128
120signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.67830464
121signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.67830464
122signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.67830464
123mitochondrion morphogenesis (GO:0070584)2.66625606
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66220082
125signal peptide processing (GO:0006465)2.66182922
126positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.64396097
127otic vesicle formation (GO:0030916)2.62574580
128actin-mediated cell contraction (GO:0070252)2.59907738
129intracellular protein transmembrane transport (GO:0065002)2.56149525
130formation of translation preinitiation complex (GO:0001731)2.55609442
131membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.55145074
132protein transmembrane transport (GO:0071806)2.54562007
133rRNA processing (GO:0006364)2.54376462
134regulation of relaxation of muscle (GO:1901077)2.50419509
135positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.49357617
136protein localization to organelle (GO:0033365)2.45888404
137rRNA metabolic process (GO:0016072)2.42944569
138sarcoplasmic reticulum calcium ion transport (GO:0070296)2.41869641
139mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.9682241
140energy coupled proton transport, down electrochemical gradient (GO:0015985)10.3190355
141ATP synthesis coupled proton transport (GO:0015986)10.3190355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.94210429
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.16849977
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.72949311
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.72879704
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.63965859
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.41118840
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.35907032
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.28558772
9* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.92418924
10* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.85015009
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83666074
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.83160869
13EZH2_22144423_ChIP-Seq_EOC_Human2.73786898
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.71148527
15* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.68285815
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67396674
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.48833417
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36025654
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.25769518
20ELK1_19687146_ChIP-ChIP_HELA_Human2.15322864
21TAF15_26573619_Chip-Seq_HEK293_Human2.07791984
22* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.06250256
23* VDR_22108803_ChIP-Seq_LS180_Human2.03410282
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90921980
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89198100
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88582861
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84454715
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83523120
29VDR_23849224_ChIP-Seq_CD4+_Human1.81579996
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.80158836
31* DCP1A_22483619_ChIP-Seq_HELA_Human1.77784072
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75218857
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73730658
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.73051904
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.72691590
36FUS_26573619_Chip-Seq_HEK293_Human1.66994537
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65579878
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65094338
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.61277509
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58966115
41* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.57179434
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50381709
43* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50249438
44* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49749400
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49549838
46ELK1_22589737_ChIP-Seq_MCF10A_Human1.45891369
47IRF1_19129219_ChIP-ChIP_H3396_Human1.44874256
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.41943972
49* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38469173
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38345240
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38050185
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37596084
53* YY1_21170310_ChIP-Seq_MESCs_Mouse1.35477813
54FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33996415
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33586379
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33163957
57GBX2_23144817_ChIP-Seq_PC3_Human1.31656414
58FOXP3_21729870_ChIP-Seq_TREG_Human1.28445789
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27838914
60HTT_18923047_ChIP-ChIP_STHdh_Human1.27407877
61* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24583482
62ER_23166858_ChIP-Seq_MCF-7_Human1.22908242
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21633548
64* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18775561
65* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16090932
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12396864
67* TTF2_22483619_ChIP-Seq_HELA_Human1.12320562
68P300_19829295_ChIP-Seq_ESCs_Human1.12299839
69* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08236416
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07221111
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.06651810
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04970365
73RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01826773
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01656587
75IGF1R_20145208_ChIP-Seq_DFB_Human1.01406151
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00730985
77TP53_22573176_ChIP-Seq_HFKS_Human1.00287070
78* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98546878
79GATA1_22025678_ChIP-Seq_K562_Human0.98444783
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97588255
81EZH2_27304074_Chip-Seq_ESCs_Mouse0.96537557
82MYC_18940864_ChIP-ChIP_HL60_Human0.96193591
83GABP_19822575_ChIP-Seq_HepG2_Human0.95258029
84NANOG_16153702_ChIP-ChIP_HESCs_Human0.94647758
85EWS_26573619_Chip-Seq_HEK293_Human0.94505709
86MYC_19079543_ChIP-ChIP_MESCs_Mouse0.94382608
87* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92839273
88* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92633829
89REST_19997604_ChIP-ChIP_NEURONS_Mouse0.92392827
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92191393
91POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91968110
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91419409
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.91188014
94RNF2_27304074_Chip-Seq_NSC_Mouse0.91142500
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90847330
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90803457
97XRN2_22483619_ChIP-Seq_HELA_Human0.90462209
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89135420
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85316404
100SALL4_22934838_ChIP-ChIP_CD34+_Human0.84968910
101AR_20517297_ChIP-Seq_VCAP_Human0.83392919
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.81679865
103NANOG_19829295_ChIP-Seq_ESCs_Human0.81469808
104SOX2_19829295_ChIP-Seq_ESCs_Human0.81469808
105SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.80727223
106ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80435985
107PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80306538
108* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77199336
109ERG_20517297_ChIP-Seq_VCAP_Human0.76665378
110FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.76136544
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.76033073
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.75297271
113SUZ12_27294783_Chip-Seq_NPCs_Mouse0.75062989
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74938057
115PCGF2_27294783_Chip-Seq_NPCs_Mouse0.72102615
116* CBX2_27304074_Chip-Seq_ESCs_Mouse0.71990556
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.71910218
118JUN_21703547_ChIP-Seq_K562_Human0.71564804
119FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.70618864
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70293030

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.48250792
2MP0002837_dystrophic_cardiac_calcinosis4.45020023
3MP0006036_abnormal_mitochondrial_physio3.99844357
4MP0004215_abnormal_myocardial_fiber3.19623435
5MP0003195_calcinosis3.04814954
6MP0006035_abnormal_mitochondrial_morpho3.02326048
7MP0003806_abnormal_nucleotide_metabolis2.88298786
8MP0009379_abnormal_foot_pigmentation2.82932375
9MP0001529_abnormal_vocalization2.81754149
10MP0004036_abnormal_muscle_relaxation2.72690298
11MP0004084_abnormal_cardiac_muscle2.66433505
12MP0000749_muscle_degeneration2.58242010
13MP0005330_cardiomyopathy2.54451137
14MP0003880_abnormal_central_pattern2.38968668
15MP0004043_abnormal_pH_regulation2.37601922
16MP0003186_abnormal_redox_activity2.32570589
17MP0006292_abnormal_olfactory_placode2.26303302
18MP0000751_myopathy2.12048636
19MP0006072_abnormal_retinal_apoptosis2.08432020
20MP0004484_altered_response_of2.06980373
21MP0004147_increased_porphyrin_level2.01077279
22MP0002972_abnormal_cardiac_muscle1.98421070
23MP0009697_abnormal_copulation1.87882508
24MP0002332_abnormal_exercise_endurance1.85598952
25MP0003787_abnormal_imprinting1.84447374
26MP0001905_abnormal_dopamine_level1.81637305
27MP0005085_abnormal_gallbladder_physiolo1.80651624
28MP0004145_abnormal_muscle_electrophysio1.77058901
29MP0005535_abnormal_body_temperature1.76340142
30MP0008775_abnormal_heart_ventricle1.75043490
31MP0005620_abnormal_muscle_contractility1.74437901
32MP0005423_abnormal_somatic_nervous1.72048833
33MP0004142_abnormal_muscle_tone1.69856232
34MP0008875_abnormal_xenobiotic_pharmacok1.66177639
35MP0002938_white_spotting1.63886649
36MP0004130_abnormal_muscle_cell1.63470801
37MP0002638_abnormal_pupillary_reflex1.61310658
38MP0003123_paternal_imprinting1.57706545
39MP0005332_abnormal_amino_acid1.57474374
40MP0006276_abnormal_autonomic_nervous1.52935194
41MP0003136_yellow_coat_color1.51131958
42MP0008995_early_reproductive_senescence1.50088813
43MP0000372_irregular_coat_pigmentation1.49297664
44MP0001727_abnormal_embryo_implantation1.47405319
45MP0002876_abnormal_thyroid_physiology1.47272197
46MP0003137_abnormal_impulse_conducting1.47196272
47MP0003011_delayed_dark_adaptation1.46882726
48MP0003221_abnormal_cardiomyocyte_apopto1.44000983
49MP0001544_abnormal_cardiovascular_syste1.40895169
50MP0005385_cardiovascular_system_phenoty1.40895169
51MP0002106_abnormal_muscle_physiology1.38916152
52MP0005266_abnormal_metabolism1.36700981
53MP0004270_analgesia1.36564163
54MP0005171_absent_coat_pigmentation1.35799807
55MP0001486_abnormal_startle_reflex1.34776898
56MP0002734_abnormal_mechanical_nocicepti1.33778612
57MP0005084_abnormal_gallbladder_morpholo1.32660171
58MP0000013_abnormal_adipose_tissue1.28279370
59MP0002139_abnormal_hepatobiliary_system1.28191312
60MP0005360_urolithiasis1.26946051
61MP0006138_congestive_heart_failure1.26872296
62MP0005379_endocrine/exocrine_gland_phen1.26522874
63MP0005636_abnormal_mineral_homeostasis1.24969656
64MP0004085_abnormal_heartbeat1.23503257
65MP0002163_abnormal_gland_morphology1.22572569
66MP0003635_abnormal_synaptic_transmissio1.22083401
67MP0005408_hypopigmentation1.21032668
68MP0005369_muscle_phenotype1.17337456
69MP0001764_abnormal_homeostasis1.17011956
70MP0000230_abnormal_systemic_arterial1.14955375
71MP0004957_abnormal_blastocyst_morpholog1.11744161
72MP0008877_abnormal_DNA_methylation1.11639928
73MP0005165_increased_susceptibility_to1.11563698
74MP0001440_abnormal_grooming_behavior1.11289908
75MP0004087_abnormal_muscle_fiber1.10193659
76MP0002736_abnormal_nociception_after1.09886337
77MP0005551_abnormal_eye_electrophysiolog1.08372694
78MP0004742_abnormal_vestibular_system1.07161457
79MP0000750_abnormal_muscle_regeneration1.07004938
80MP0004924_abnormal_behavior1.05604737
81MP0005386_behavior/neurological_phenoty1.05604737
82MP0010386_abnormal_urinary_bladder1.05117333
83MP0002127_abnormal_cardiovascular_syste1.04642811
84MP0003950_abnormal_plasma_membrane1.04560433
85MP0002971_abnormal_brown_adipose1.02986731
86MP0000631_abnormal_neuroendocrine_gland1.02098894
87MP0005253_abnormal_eye_physiology1.01940121
88MP0003315_abnormal_perineum_morphology1.01937411
89MP0005365_abnormal_bile_salt1.01805138
90MP0002572_abnormal_emotion/affect_behav1.01141737
91MP0002067_abnormal_sensory_capabilities1.01060558
92MP0001970_abnormal_pain_threshold1.00375002
93MP0005584_abnormal_enzyme/coenzyme_acti1.00282520
94MP0003890_abnormal_embryonic-extraembry0.99881824
95MP0005376_homeostasis/metabolism_phenot0.97975751
96MP0002160_abnormal_reproductive_system0.96976137
97MP0003121_genomic_imprinting0.96687737
98MP0003941_abnormal_skin_development0.96687109
99MP0002184_abnormal_innervation0.96683550
100MP0008058_abnormal_DNA_repair0.96179399
101MP0009046_muscle_twitch0.96154996
102MP0003724_increased_susceptibility_to0.95373473
103MP0008789_abnormal_olfactory_epithelium0.93112649
104MP0002272_abnormal_nervous_system0.92762205
105MP0002090_abnormal_vision0.92230803
106MP0001188_hyperpigmentation0.90395491
107MP0004885_abnormal_endolymph0.89303213
108MP0002557_abnormal_social/conspecific_i0.88902267
109MP0002063_abnormal_learning/memory/cond0.88847514
110MP0005646_abnormal_pituitary_gland0.88679484
111MP0009745_abnormal_behavioral_response0.88095558
112MP0000747_muscle_weakness0.87783075
113MP0001968_abnormal_touch/_nociception0.87055449
114MP0003718_maternal_effect0.83783483
115MP0005670_abnormal_white_adipose0.83762512
116MP0001293_anophthalmia0.82360914
117MP0004859_abnormal_synaptic_plasticity0.82298503
118MP0001501_abnormal_sleep_pattern0.82232664
119MP0002822_catalepsy0.81409655
120MP0000759_abnormal_skeletal_muscle0.81224965
121MP0005451_abnormal_body_composition0.80566616
122MP0008004_abnormal_stomach_pH0.79909030
123MP0000343_altered_response_to0.79873474
124MP0001984_abnormal_olfaction0.79102451
125MP0000778_abnormal_nervous_system0.78239689
126MP0002752_abnormal_somatic_nervous0.78197118
127MP0000955_abnormal_spinal_cord0.77956431
128MP0002269_muscular_atrophy0.77818554
129MP0002066_abnormal_motor_capabilities/c0.76213978
130MP0005319_abnormal_enzyme/_coenzyme0.76142716
131MP0002277_abnormal_respiratory_mucosa0.74619372
132MP0002064_seizures0.72375305
133MP0002078_abnormal_glucose_homeostasis0.71855388
134MP0001485_abnormal_pinna_reflex0.71786841
135MP0002733_abnormal_thermal_nociception0.70709252
136MP0008872_abnormal_physiological_respon0.69558061
137MP0009643_abnormal_urine_homeostasis0.68335129
138MP0002118_abnormal_lipid_homeostasis0.66851725
139MP0000358_abnormal_cell_content/0.66406649
140MP0010630_abnormal_cardiac_muscle0.62929602
141MP0002735_abnormal_chemical_nociception0.62732965
142MP0003567_abnormal_fetal_cardiomyocyte0.62649775

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.96957735
2Abnormal mitochondria in muscle tissue (HP:0008316)7.41407276
3Acute encephalopathy (HP:0006846)6.78644693
4Progressive macrocephaly (HP:0004481)6.77497706
5Mitochondrial inheritance (HP:0001427)6.47980429
6Increased CSF lactate (HP:0002490)5.80012876
7Hepatic necrosis (HP:0002605)5.58934209
8Hepatocellular necrosis (HP:0001404)5.47878642
9Cerebral edema (HP:0002181)5.38246923
10Increased serum pyruvate (HP:0003542)4.79714713
11Abnormality of glycolysis (HP:0004366)4.79714713
12Increased hepatocellular lipid droplets (HP:0006565)4.67070537
13Lipid accumulation in hepatocytes (HP:0006561)4.60264391
14Exercise intolerance (HP:0003546)4.27210158
15Lactic acidosis (HP:0003128)4.26796838
16Respiratory failure (HP:0002878)4.16389587
17Increased intramyocellular lipid droplets (HP:0012240)4.02849070
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.02283488
19Decreased activity of mitochondrial respiratory chain (HP:0008972)4.02283488
20Optic disc pallor (HP:0000543)3.94963848
21Renal Fanconi syndrome (HP:0001994)3.85978047
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.83979340
23Increased muscle lipid content (HP:0009058)3.82693598
24Leukodystrophy (HP:0002415)3.69870890
25Increased serum lactate (HP:0002151)3.61890329
263-Methylglutaconic aciduria (HP:0003535)3.48564132
27Nemaline bodies (HP:0003798)3.43058531
28Muscle fiber inclusion bodies (HP:0100299)3.42159532
29Myokymia (HP:0002411)3.40866054
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.34538450
31Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.27705456
32Pallor (HP:0000980)3.20361596
33Lethargy (HP:0001254)3.09713460
34Abnormality of urine glucose concentration (HP:0011016)3.03983245
35Glycosuria (HP:0003076)3.03983245
36Generalized aminoaciduria (HP:0002909)2.96236544
37Dicarboxylic aciduria (HP:0003215)2.94126862
38Abnormality of dicarboxylic acid metabolism (HP:0010995)2.94126862
39Exertional dyspnea (HP:0002875)2.92674838
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.89734022
41Abnormality of alanine metabolism (HP:0010916)2.89734022
42Hyperalaninemia (HP:0003348)2.89734022
43Neuroendocrine neoplasm (HP:0100634)2.88821866
44Respiratory difficulties (HP:0002880)2.88260290
45X-linked dominant inheritance (HP:0001423)2.82470836
46Palpitations (HP:0001962)2.80517535
47Pheochromocytoma (HP:0002666)2.79871390
48Hypoglycemic coma (HP:0001325)2.79212209
49Conjunctival hamartoma (HP:0100780)2.77793569
50Abnormality of renal resorption (HP:0011038)2.64015981
51CNS demyelination (HP:0007305)2.63277852
52Calf muscle hypertrophy (HP:0008981)2.62978059
53Muscle hypertrophy of the lower extremities (HP:0008968)2.62936902
54Abnormality of cells of the erythroid lineage (HP:0012130)2.51312871
55Rhabdomyolysis (HP:0003201)2.50657471
56Myoglobinuria (HP:0002913)2.50073840
57Methylmalonic aciduria (HP:0012120)2.47373095
58Abnormality of fatty-acid metabolism (HP:0004359)2.44379378
59Vomiting (HP:0002013)2.43909286
60Bundle branch block (HP:0011710)2.31168749
61Ketoacidosis (HP:0001993)2.31076924
62Abnormal number of erythroid precursors (HP:0012131)2.30998508
63Nausea (HP:0002018)2.30290104
64Microvesicular hepatic steatosis (HP:0001414)2.28695316
65Exercise-induced muscle cramps (HP:0003710)2.28386581
66Hyperphosphaturia (HP:0003109)2.21699122
67Methylmalonic acidemia (HP:0002912)2.21339271
68Proximal tubulopathy (HP:0000114)2.20918040
69Sudden death (HP:0001699)2.18196287
70Ragged-red muscle fibers (HP:0003200)2.17758634
71Myotonia (HP:0002486)2.15548836
72Septo-optic dysplasia (HP:0100842)2.13378491
73Exercise-induced myalgia (HP:0003738)2.12409008
74Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.10921582
75Esophageal neoplasm (HP:0100751)2.06065826
76Neoplasm of head and neck (HP:0012288)2.06065826
77Emotional lability (HP:0000712)2.04847588
78Renal cortical cysts (HP:0000803)2.04348777
79Gliosis (HP:0002171)2.04079604
80Rimmed vacuoles (HP:0003805)1.89639453
81Neoplasm of the adrenal gland (HP:0100631)1.88355096
82Ventricular tachycardia (HP:0004756)1.88093695
83Ketosis (HP:0001946)1.87299880
84Cerebral hemorrhage (HP:0001342)1.85594064
85Abnormality of placental membranes (HP:0011409)1.84393967
86Amniotic constriction ring (HP:0009775)1.84393967
87* Metabolic acidosis (HP:0001942)1.83944110
88EMG: myopathic abnormalities (HP:0003458)1.83623015
89Type 1 muscle fiber predominance (HP:0003803)1.83403532
90Stenosis of the external auditory canal (HP:0000402)1.83364413
91Abnormal urine phosphate concentration (HP:0012599)1.80134259
92Blindness (HP:0000618)1.79434289
93Renal tubular dysfunction (HP:0000124)1.79265891
94Parakeratosis (HP:0001036)1.79196318
95Abnormality of methionine metabolism (HP:0010901)1.78339349
96Absence seizures (HP:0002121)1.75261584
97Aplastic anemia (HP:0001915)1.74669703
98Medial flaring of the eyebrow (HP:0010747)1.74286681
99Hypothermia (HP:0002045)1.72987097
100Abnormal pupillary function (HP:0007686)1.71261983
101Hyperammonemia (HP:0001987)1.70732908
102Hyperinsulinemic hypoglycemia (HP:0000825)1.70589336
103Abnormality of the calf musculature (HP:0001430)1.69283599
104Lipoatrophy (HP:0100578)1.69169556
105Maternal diabetes (HP:0009800)1.69031980
106Abnormality of serum amino acid levels (HP:0003112)1.67093434
107Absent septum pellucidum (HP:0001331)1.66319015
108Congenital, generalized hypertrichosis (HP:0004540)1.66015712
109Hyperglycinuria (HP:0003108)1.65695658
110Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64978713
111Primary atrial arrhythmia (HP:0001692)1.62911152
112Hyperventilation (HP:0002883)1.62648764
113Megaloblastic anemia (HP:0001889)1.62240059
114Abnormal hemoglobin (HP:0011902)1.61771025
115Atrial fibrillation (HP:0005110)1.60879688
116Macrocytic anemia (HP:0001972)1.60153841
117Abnormality of aromatic amino acid family metabolism (HP:0004338)1.59956900
118Hypoplastic left heart (HP:0004383)1.59169271
119Aplasia/Hypoplasia of the sacrum (HP:0008517)1.58850767
120Dilated cardiomyopathy (HP:0001644)1.58410307
121Left ventricular hypertrophy (HP:0001712)1.56994712
122Depressed nasal ridge (HP:0000457)1.56886531
123Tinnitus (HP:0000360)1.56695284
124Heart block (HP:0012722)1.56189995
125Confusion (HP:0001289)1.55622416
126Congenital ichthyosiform erythroderma (HP:0007431)1.55525579
127Multiple enchondromatosis (HP:0005701)1.54400720
128Supraventricular arrhythmia (HP:0005115)1.54140016
129Distal arthrogryposis (HP:0005684)1.52680859
130Hyperglycinemia (HP:0002154)1.52626869
131Molar tooth sign on MRI (HP:0002419)1.52506104
132Abnormality of midbrain morphology (HP:0002418)1.52506104
133Muscle stiffness (HP:0003552)1.51008009
134Supraventricular tachycardia (HP:0004755)1.50141535
135Reticulocytopenia (HP:0001896)1.49253346

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.58931789
2MYLK3.39573819
3NME13.38755895
4VRK23.03976847
5OBSCN2.94510643
6MAP3K122.93130220
7STK162.91777868
8BCKDK2.64979337
9MST42.63356660
10PDK42.49121175
11PDK32.49121175
12PBK2.38619837
13GRK72.26753308
14MUSK2.17733171
15PDK21.99509013
16CASK1.97981113
17CDC71.86714962
18EIF2AK31.86654727
19EIF2AK11.77618042
20ARAF1.76103110
21WNK41.74076766
22STK391.72243150
23VRK11.68117705
24STK241.60423930
25MAP2K71.60232163
26BMPR21.56123669
27OXSR11.52136960
28MARK11.40275481
29PLK21.36226051
30PNCK1.35273973
31PINK11.25097170
32ZAK1.24014557
33WEE11.23750353
34ADRBK21.20876154
35DMPK1.19740915
36GRK51.19015976
37WNK31.15942114
38NTRK31.14905455
39TLK11.14837271
40BCR1.11214895
41ABL21.10237016
42PIK3CG1.05858874
43RIPK40.99161744
44STK38L0.99000409
45UHMK10.97372768
46BMPR1B0.97334993
47BUB10.97054663
48TNIK0.96896697
49RPS6KB20.95748534
50LIMK10.94570691
51MINK10.92662675
52MAP3K40.92383928
53PIK3CA0.92199201
54DYRK30.91755455
55INSRR0.91230196
56SRPK10.88945196
57CDK190.88569834
58CAMK2A0.85943087
59CCNB10.85566368
60PLK40.84945648
61CAMK2D0.82674579
62PRKCE0.82109869
63CSNK1E0.81620382
64KDR0.81408426
65PIM20.81038291
66PHKG20.80901875
67PHKG10.80901875
68NEK20.80828408
69TIE10.79951811
70PASK0.77923295
71CAMK2G0.73213135
72ILK0.72895108
73MKNK20.71385310
74ACVR1B0.71302983
75MAP2K40.71222840
76CDK30.71209720
77TAF10.70382707
78ADRBK10.69629753
79LATS20.69088131
80BRAF0.66816770
81CAMK10.66174831
82TTK0.65072727
83AURKB0.64925283
84FRK0.64751132
85MAP3K90.64484646
86EIF2AK20.63837269
87CAMK2B0.63771515
88AKT30.63556043
89MST1R0.62633457
90PRKACA0.60845905
91LRRK20.60164816
92DYRK20.58223430
93MAPK120.58194521
94PRKG10.57869284
95MAP4K20.56235547
96NEK10.55640442
97PRKACB0.54061726
98EPHA40.53993677
99PLK10.53517811
100MAPK130.53390398
101CSNK2A10.52990022
102TEC0.51936565
103SCYL20.51605578
104PRKCG0.50177199
105ERBB30.49531592
106TTN0.48322972
107NTRK20.47740112
108IRAK30.46736198
109TSSK60.45055524
110DAPK10.44993227
111GRK10.44963453
112PAK30.44510695
113MAPKAPK50.42664872
114DAPK30.42357589
115CDK80.41096762
116CAMKK20.40882069
117CSNK2A20.39966026
118BRSK20.37219997
119ERBB40.36221141
120YES10.35964742
121PLK30.35680554
122MAPK150.34677383
123FGR0.34163545
124PRKCQ0.32749875
125MKNK10.32196637
126PTK2B0.31893468
127MAPK40.28313437
128NUAK10.27872872
129AURKA0.27821553

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.09039085
2Parkinsons disease_Homo sapiens_hsa050125.28466310
3Alzheimers disease_Homo sapiens_hsa050103.95168195
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.76783572
5Huntingtons disease_Homo sapiens_hsa050163.70762383
6* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.44425949
7Proteasome_Homo sapiens_hsa030503.18287789
8Ribosome_Homo sapiens_hsa030102.87715070
9* Cardiac muscle contraction_Homo sapiens_hsa042602.67460808
10Propanoate metabolism_Homo sapiens_hsa006402.49725942
11Protein export_Homo sapiens_hsa030602.47116345
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.13633398
13Fatty acid elongation_Homo sapiens_hsa000622.03346763
14Sulfur metabolism_Homo sapiens_hsa009201.94342115
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.89476083
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86853309
17Pyruvate metabolism_Homo sapiens_hsa006201.80680956
18RNA polymerase_Homo sapiens_hsa030201.77030028
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73344617
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63614818
21Collecting duct acid secretion_Homo sapiens_hsa049661.52085876
22Carbon metabolism_Homo sapiens_hsa012001.51351737
23Fatty acid degradation_Homo sapiens_hsa000711.39709682
24Butanoate metabolism_Homo sapiens_hsa006501.23082260
25Peroxisome_Homo sapiens_hsa041461.15031632
26Fatty acid metabolism_Homo sapiens_hsa012121.12340330
27Phenylalanine metabolism_Homo sapiens_hsa003600.98887337
28Pyrimidine metabolism_Homo sapiens_hsa002400.98265160
29* Metabolic pathways_Homo sapiens_hsa011000.97854452
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97397769
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94414812
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94048294
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93006689
34Glutathione metabolism_Homo sapiens_hsa004800.87169630
35Asthma_Homo sapiens_hsa053100.85202857
36Vibrio cholerae infection_Homo sapiens_hsa051100.84491072
37Tyrosine metabolism_Homo sapiens_hsa003500.84039417
38beta-Alanine metabolism_Homo sapiens_hsa004100.83273431
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83085019
40Folate biosynthesis_Homo sapiens_hsa007900.81549864
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79368283
42RNA transport_Homo sapiens_hsa030130.75184620
43Circadian rhythm_Homo sapiens_hsa047100.73823340
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.71831192
45Tryptophan metabolism_Homo sapiens_hsa003800.68422998
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68325948
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66927495
48One carbon pool by folate_Homo sapiens_hsa006700.63862535
49Purine metabolism_Homo sapiens_hsa002300.62708703
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62067011
51Histidine metabolism_Homo sapiens_hsa003400.61405043
52PPAR signaling pathway_Homo sapiens_hsa033200.60205366
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58041917
54Rheumatoid arthritis_Homo sapiens_hsa053230.56251269
55Chemical carcinogenesis_Homo sapiens_hsa052040.55574389
56Arginine biosynthesis_Homo sapiens_hsa002200.55056776
57Morphine addiction_Homo sapiens_hsa050320.53210951
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52997221
59Arginine and proline metabolism_Homo sapiens_hsa003300.52979213
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52503788
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51848300
62Arachidonic acid metabolism_Homo sapiens_hsa005900.51784759
63Mineral absorption_Homo sapiens_hsa049780.51486309
64Biosynthesis of amino acids_Homo sapiens_hsa012300.50798939
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50375836
66Insulin secretion_Homo sapiens_hsa049110.48548428
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48215203
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47778882
69Nitrogen metabolism_Homo sapiens_hsa009100.46784281
70Regulation of autophagy_Homo sapiens_hsa041400.45042543
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.45002414
72Glutamatergic synapse_Homo sapiens_hsa047240.44390614
73Circadian entrainment_Homo sapiens_hsa047130.44104069
74Starch and sucrose metabolism_Homo sapiens_hsa005000.43903650
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43388209
76Olfactory transduction_Homo sapiens_hsa047400.43305678
77Amphetamine addiction_Homo sapiens_hsa050310.40097783
78Dopaminergic synapse_Homo sapiens_hsa047280.38192054
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37079366
80Steroid biosynthesis_Homo sapiens_hsa001000.36937065
81Fanconi anemia pathway_Homo sapiens_hsa034600.36088478
82RNA degradation_Homo sapiens_hsa030180.35353368
83Oocyte meiosis_Homo sapiens_hsa041140.34098711
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34062614
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.33593266
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31637759
87Nucleotide excision repair_Homo sapiens_hsa034200.31617891
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.31419575
89Basal transcription factors_Homo sapiens_hsa030220.30660041
90Linoleic acid metabolism_Homo sapiens_hsa005910.30232060
91Nicotine addiction_Homo sapiens_hsa050330.30219961
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29552732
93Homologous recombination_Homo sapiens_hsa034400.29189508
94Serotonergic synapse_Homo sapiens_hsa047260.28499097
95Phagosome_Homo sapiens_hsa041450.27822659
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.27721893
97Fructose and mannose metabolism_Homo sapiens_hsa000510.27546633
98Retinol metabolism_Homo sapiens_hsa008300.24483355
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24209379
100Spliceosome_Homo sapiens_hsa030400.24148598
101Galactose metabolism_Homo sapiens_hsa000520.23387821
102Pentose phosphate pathway_Homo sapiens_hsa000300.23132117
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22593949
104Dilated cardiomyopathy_Homo sapiens_hsa054140.22069889
105Oxytocin signaling pathway_Homo sapiens_hsa049210.21696671
106Taste transduction_Homo sapiens_hsa047420.20414120
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.19868129
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.19686694
109Vitamin digestion and absorption_Homo sapiens_hsa049770.18823662
110mRNA surveillance pathway_Homo sapiens_hsa030150.17990477
111Mismatch repair_Homo sapiens_hsa034300.17989401
112Renin secretion_Homo sapiens_hsa049240.17883176
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.17270866
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16500817
115Ether lipid metabolism_Homo sapiens_hsa005650.15374313
116Sulfur relay system_Homo sapiens_hsa041220.14528720
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14398382
118Calcium signaling pathway_Homo sapiens_hsa040200.13963343
119Fat digestion and absorption_Homo sapiens_hsa049750.12158364
120GABAergic synapse_Homo sapiens_hsa047270.11543001
121Synaptic vesicle cycle_Homo sapiens_hsa047210.09599549
122DNA replication_Homo sapiens_hsa030300.07021231
123Phototransduction_Homo sapiens_hsa047440.06707924

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