ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.84362400
2	ribosomal small subunit assembly (GO:0000028)	6.80682344
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.31831629
4	ATP synthesis coupled proton transport (GO:0015986)	6.31831629
5	viral transcription (GO:0019083)	5.81935738
6	translational termination (GO:0006415)	5.71392320
7	maturation of SSU-rRNA (GO:0030490)	5.63550549
8	ribosomal small subunit biogenesis (GO:0042274)	5.61769384
9	tongue development (GO:0043586)	5.33478177
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.14111573
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.08864710
12	protein targeting to ER (GO:0045047)	5.07095363
13	cotranslational protein targeting to membrane (GO:0006613)	5.05003465
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.88949305
15	platelet dense granule organization (GO:0060155)	4.81258057
16	protein localization to endoplasmic reticulum (GO:0070972)	4.80087696
17	chaperone-mediated protein transport (GO:0072321)	4.77387670
18	translational elongation (GO:0006414)	4.44571515
19	respiratory electron transport chain (GO:0022904)	4.44511862
20	electron transport chain (GO:0022900)	4.41890538
21	cellular protein complex disassembly (GO:0043624)	4.26661990
22	postsynaptic membrane organization (GO:0001941)	4.24397008
23	viral life cycle (GO:0019058)	4.22927434
24	regulation of action potential (GO:0098900)	4.19140651
25	negative regulation of mast cell activation (GO:0033004)	4.08937629
26	DNA double-strand break processing (GO:0000729)	4.06176067
27	ATP biosynthetic process (GO:0006754)	3.91454600
28	neurotransmitter uptake (GO:0001504)	3.91408859
29	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.84103802
30	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.77089576
31	translational initiation (GO:0006413)	3.76421976
32	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.74196867
33	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.70873740
34	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.65821854
35	substrate-independent telencephalic tangential migration (GO:0021826)	3.64648549
36	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.64648549
37	protein targeting to membrane (GO:0006612)	3.64404587
38	behavioral response to nicotine (GO:0035095)	3.62160881
39	ribonucleoprotein complex disassembly (GO:0032988)	3.55516546
40	macromolecular complex disassembly (GO:0032984)	3.54309118
41	protein complex disassembly (GO:0043241)	3.54216948
42	translation (GO:0006412)	3.50635754
43	protein complex biogenesis (GO:0070271)	3.42410202
44	potassium ion import (GO:0010107)	3.41651276
45	organelle disassembly (GO:1903008)	3.40581583
46	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.35541191
47	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.35541191
48	NADH dehydrogenase complex assembly (GO:0010257)	3.35541191
49	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.32947130
50	ribosomal large subunit biogenesis (GO:0042273)	3.30266952
51	peptidyl-histidine modification (GO:0018202)	3.30253418
52	regulation of synapse structural plasticity (GO:0051823)	3.21866456
53	hydrogen ion transmembrane transport (GO:1902600)	3.21110031
54	C4-dicarboxylate transport (GO:0015740)	3.20380500
55	protein maturation by protein folding (GO:0022417)	3.18833496
56	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.18155421
57	positive regulation of TOR signaling (GO:0032008)	3.16942600
58	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.16120987
59	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.16120987
60	preassembly of GPI anchor in ER membrane (GO:0016254)	3.08893718
61	GTP biosynthetic process (GO:0006183)	3.05701019
62	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	3.05373337
63	presynaptic membrane assembly (GO:0097105)	3.04619868
64	glycerophospholipid catabolic process (GO:0046475)	3.04271666
65	aldehyde catabolic process (GO:0046185)	3.03542956
66	mitochondrial respiratory chain complex assembly (GO:0033108)	3.00947320
67	regulation of penile erection (GO:0060405)	2.94790098
68	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.91976277
69	thalamus development (GO:0021794)	2.90054243
70	neuronal action potential propagation (GO:0019227)	2.89290503
71	DNA deamination (GO:0045006)	2.88109412
72	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	2.86446598
73	nucleoside triphosphate biosynthetic process (GO:0009142)	2.86294423
74	negative regulation of heart rate (GO:0010459)	2.83653362
75	response to pheromone (GO:0019236)	2.80168967
76	DNA demethylation (GO:0080111)	2.80049165
77	proton transport (GO:0015992)	2.79930139
78	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.79581545
79	pseudouridine synthesis (GO:0001522)	2.78184080
80	membrane repolarization during action potential (GO:0086011)	2.77622708
81	positive regulation of protein homooligomerization (GO:0032464)	2.76229650
82	parturition (GO:0007567)	2.76108929
83	UTP metabolic process (GO:0046051)	2.73785153
84	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.73312413
85	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.71361585
86	regulation of mitotic spindle checkpoint (GO:1903504)	2.71361585
87	hydrogen transport (GO:0006818)	2.70972653
88	regulation of cardiac muscle cell contraction (GO:0086004)	2.70956135
89	regulation of fever generation (GO:0031620)	2.69707973
90	hypothalamus development (GO:0021854)	2.68191721
91	UTP biosynthetic process (GO:0006228)	2.65120474
92	seminiferous tubule development (GO:0072520)	2.64583037
93	protein heterotetramerization (GO:0051290)	2.63011635
94	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.60800286
95	DNA dealkylation (GO:0035510)	2.59694530
96	cellular component biogenesis (GO:0044085)	2.58242126
97	regulation of respiratory system process (GO:0044065)	2.56878511
98	somite development (GO:0061053)	2.53852719
99	GPI anchor biosynthetic process (GO:0006506)	2.52551229
100	mRNA catabolic process (GO:0006402)	2.51208526

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.27853630
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.60541917
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.71166169
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.22902166
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.10139001
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.78639464
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.41012427
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.28706366
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.28145968
10	VDR_22108803_ChIP-Seq_LS180_Human	2.22671774
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.11373488
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.09172746
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.09159301
14	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.07951843
15	ELK1_19687146_ChIP-ChIP_HELA_Human	1.97384649
16	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.96310054
17	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.85528940
18	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.80113170
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.79555960
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.71160895
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.65436564
22	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.64065910
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.63868472
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.63394365
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.61480131
26	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.60837669
27	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.57292905
28	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.55498128
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.55234397
30	FUS_26573619_Chip-Seq_HEK293_Human	1.55147678
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.52122075
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.52027203
33	VDR_23849224_ChIP-Seq_CD4+_Human	1.47335481
34	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.45919251
35	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.44996879
36	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.39910839
37	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.37701155
38	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.35912376
39	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.33767109
40	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.33321416
41	P300_19829295_ChIP-Seq_ESCs_Human	1.32073120
42	RNF2_27304074_Chip-Seq_NSC_Mouse	1.31803610
43	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.29882815
44	FOXP3_21729870_ChIP-Seq_TREG_Human	1.29326243
45	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.27427066
46	NCOR_22424771_ChIP-Seq_293T_Human	1.26838419
47	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.25103257
48	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.23128590
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19593955
50	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.19265359
51	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.16196622
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16048925
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16048925
54	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.15854720
55	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.15045544
56	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.13166380
57	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.12904315
58	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.11494625
59	GBX2_23144817_ChIP-Seq_PC3_Human	1.11328726
60	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.09825465
61	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.09741258
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09146111
63	REST_21632747_ChIP-Seq_MESCs_Mouse	1.07554794
64	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06711051
65	MYC_19829295_ChIP-Seq_ESCs_Human	1.06665372
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06547186
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06547186
68	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.06468719
69	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.06001905
70	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05315321
71	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.05107565
72	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03277886
73	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02930383
74	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.02201321
75	BCAT_22108803_ChIP-Seq_LS180_Human	1.01078246
76	ERA_21632823_ChIP-Seq_H3396_Human	0.99353834
77	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.99029200
78	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.98931857
79	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.98610501
80	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98344940
81	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.98344940
82	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.97833540
83	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.96381759
84	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.96378482
85	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.96344053
86	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.95641260
87	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.95557505
88	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.95009113
89	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.93567361
90	EWS_26573619_Chip-Seq_HEK293_Human	0.92971852
91	TTF2_22483619_ChIP-Seq_HELA_Human	0.91818148
92	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.90163142
93	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.89626568
94	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.89583697
95	AR_20517297_ChIP-Seq_VCAP_Human	0.89196708
96	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.89190376
97	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.88996851
98	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.88842885
99	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.87350366
100	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.87350366

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	5.41517572
2	MP0006292_abnormal_olfactory_placode	5.16115019
3	MP0009379_abnormal_foot_pigmentation	4.08388665
4	MP0004147_increased_porphyrin_level	3.14268357
5	MP0008004_abnormal_stomach_pH	2.98855093
6	MP0004885_abnormal_endolymph	2.49661932
7	MP0001986_abnormal_taste_sensitivity	2.44607119
8	MP0005423_abnormal_somatic_nervous	2.41266406
9	MP0003787_abnormal_imprinting	2.37864452
10	MP0002735_abnormal_chemical_nociception	2.35172854
11	MP0003880_abnormal_central_pattern	2.23386663
12	MP0001968_abnormal_touch/_nociception	2.21440351
13	MP0005377_hearing/vestibular/ear_phenot	2.19659582
14	MP0003878_abnormal_ear_physiology	2.19659582
15	MP0002736_abnormal_nociception_after	2.17611829
16	MP0003123_paternal_imprinting	2.05999332
17	MP0004133_heterotaxia	1.96624270
18	MP0008789_abnormal_olfactory_epithelium	1.94556634
19	MP0001293_anophthalmia	1.89457344
20	MP0006276_abnormal_autonomic_nervous	1.86704256
21	MP0003136_yellow_coat_color	1.70757749
22	MP0000372_irregular_coat_pigmentation	1.65874609
23	MP0004142_abnormal_muscle_tone	1.61963271
24	MP0005499_abnormal_olfactory_system	1.61338921
25	MP0005394_taste/olfaction_phenotype	1.61338921
26	MP0002653_abnormal_ependyma_morphology	1.58915607
27	MP0001919_abnormal_reproductive_system	1.55802439
28	MP0002733_abnormal_thermal_nociception	1.45421448
29	MP0002638_abnormal_pupillary_reflex	1.45365670
30	MP0001486_abnormal_startle_reflex	1.45246491
31	MP0005671_abnormal_response_to	1.43098944
32	MP0000049_abnormal_middle_ear	1.41871127
33	MP0008872_abnormal_physiological_respon	1.41389619
34	MP0001970_abnormal_pain_threshold	1.40462733
35	MP0003879_abnormal_hair_cell	1.37526299
36	MP0000516_abnormal_urinary_system	1.36069063
37	MP0005367_renal/urinary_system_phenotyp	1.36069063
38	MP0002272_abnormal_nervous_system	1.35421634
39	MP0001485_abnormal_pinna_reflex	1.35352777
40	MP0005551_abnormal_eye_electrophysiolog	1.31628875
41	MP0008875_abnormal_xenobiotic_pharmacok	1.29155230
42	MP0002254_reproductive_system_inflammat	1.28714345
43	MP0008877_abnormal_DNA_methylation	1.27867886
44	MP0003567_abnormal_fetal_cardiomyocyte	1.27539998
45	MP0003195_calcinosis	1.25622115
46	MP0005084_abnormal_gallbladder_morpholo	1.25251910
47	MP0002734_abnormal_mechanical_nocicepti	1.20769015
48	MP0002102_abnormal_ear_morphology	1.19878680
49	MP0003186_abnormal_redox_activity	1.17749719
50	MP0005389_reproductive_system_phenotype	1.16713908
51	MP0001542_abnormal_bone_strength	1.16540434
52	MP0006072_abnormal_retinal_apoptosis	1.14760552
53	MP0003121_genomic_imprinting	1.14572877
54	MP0004145_abnormal_muscle_electrophysio	1.13253616
55	MP0000631_abnormal_neuroendocrine_gland	1.12435021
56	MP0009745_abnormal_behavioral_response	1.05131912
57	MP0002928_abnormal_bile_duct	1.04065793
58	MP0003806_abnormal_nucleotide_metabolis	1.03862865
59	MP0003718_maternal_effect	0.95704100
60	MP0002095_abnormal_skin_pigmentation	0.95352904
61	MP0009046_muscle_twitch	0.95036816
62	MP0002751_abnormal_autonomic_nervous	0.94342016
63	MP0005645_abnormal_hypothalamus_physiol	0.94011948
64	MP0001529_abnormal_vocalization	0.91889272
65	MP0002557_abnormal_social/conspecific_i	0.91755821
66	MP0005174_abnormal_tail_pigmentation	0.91536200
67	MP0003786_premature_aging	0.91215635
68	MP0002572_abnormal_emotion/affect_behav	0.90610671
69	MP0009384_cardiac_valve_regurgitation	0.90147774
70	MP0008995_early_reproductive_senescence	0.88727939
71	MP0002184_abnormal_innervation	0.88591322
72	MP0003890_abnormal_embryonic-extraembry	0.87973714
73	MP0002234_abnormal_pharynx_morphology	0.87746086
74	MP0008775_abnormal_heart_ventricle	0.87658893
75	MP0001963_abnormal_hearing_physiology	0.84909825
76	MP0003635_abnormal_synaptic_transmissio	0.82990984
77	MP0005075_abnormal_melanosome_morpholog	0.80615041
78	MP0000026_abnormal_inner_ear	0.80388644
79	MP0005195_abnormal_posterior_eye	0.80296329
80	MP0002160_abnormal_reproductive_system	0.79382931
81	MP0005171_absent_coat_pigmentation	0.79201791
82	MP0002163_abnormal_gland_morphology	0.78892394
83	MP0002697_abnormal_eye_size	0.78299443
84	MP0002752_abnormal_somatic_nervous	0.75459853
85	MP0004742_abnormal_vestibular_system	0.75258732
86	MP0000427_abnormal_hair_cycle	0.74735850
87	MP0005646_abnormal_pituitary_gland	0.74584583
88	MP0001440_abnormal_grooming_behavior	0.73205857
89	MP0003137_abnormal_impulse_conducting	0.72659960
90	MP0000955_abnormal_spinal_cord	0.72597158
91	MP0003693_abnormal_embryo_hatching	0.71493536
92	MP0002210_abnormal_sex_determination	0.71241570
93	MP0004270_analgesia	0.71125760
94	MP0003937_abnormal_limbs/digits/tail_de	0.68134792
95	MP0002277_abnormal_respiratory_mucosa	0.65596499
96	MP0006035_abnormal_mitochondrial_morpho	0.64042142
97	MP0005386_behavior/neurological_phenoty	0.62264715
98	MP0004924_abnormal_behavior	0.62264715
99	MP0003936_abnormal_reproductive_system	0.61581984
100	MP0004043_abnormal_pH_regulation	0.61352153

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.24898000
2	Reticulocytopenia (HP:0001896)	4.21118654
3	Abnormality of midbrain morphology (HP:0002418)	3.90923735
4	Molar tooth sign on MRI (HP:0002419)	3.90923735
5	Abnormality of cells of the erythroid lineage (HP:0012130)	3.84931950
6	Mitochondrial inheritance (HP:0001427)	3.70844273
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.61812722
8	Acute encephalopathy (HP:0006846)	3.52568280
9	Septo-optic dysplasia (HP:0100842)	3.49415962
10	Progressive macrocephaly (HP:0004481)	3.43379486
11	Abnormal number of erythroid precursors (HP:0012131)	3.42936760
12	Lipid accumulation in hepatocytes (HP:0006561)	3.34994491
13	Increased hepatocellular lipid droplets (HP:0006565)	3.31705412
14	Renal Fanconi syndrome (HP:0001994)	3.27553680
15	Increased CSF lactate (HP:0002490)	3.19283635
16	Elevated erythrocyte sedimentation rate (HP:0003565)	3.14315415
17	Absent/shortened dynein arms (HP:0200106)	3.03060856
18	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.03060856
19	Macrocytic anemia (HP:0001972)	2.94969345
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.84982271
21	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.83149076
22	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.81693028
23	Optic nerve hypoplasia (HP:0000609)	2.76218201
24	Chronic bronchitis (HP:0004469)	2.74879817
25	Increased intramyocellular lipid droplets (HP:0012240)	2.70570098
26	Hepatocellular necrosis (HP:0001404)	2.68331902
27	Hemiparesis (HP:0001269)	2.67617044
28	Cerebral edema (HP:0002181)	2.67032581
29	Abolished electroretinogram (ERG) (HP:0000550)	2.65272505
30	Absent thumb (HP:0009777)	2.61942296
31	True hermaphroditism (HP:0010459)	2.61818289
32	Hemiplegia (HP:0002301)	2.54755204
33	Sensory axonal neuropathy (HP:0003390)	2.48882584
34	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.47524637
35	Congenital stationary night blindness (HP:0007642)	2.42963997
36	Large eyes (HP:0001090)	2.42920987
37	Abnormal respiratory motile cilium physiology (HP:0012261)	2.41725525
38	Increased muscle lipid content (HP:0009058)	2.38760243
39	Colon cancer (HP:0003003)	2.37176473
40	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.35589626
41	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.35589626
42	Male pseudohermaphroditism (HP:0000037)	2.34674004
43	Abnormality of magnesium homeostasis (HP:0004921)	2.32133984
44	Chronic hepatic failure (HP:0100626)	2.27337745
45	Exertional dyspnea (HP:0002875)	2.26418650
46	Abnormal rod and cone electroretinograms (HP:0008323)	2.25881134
47	Double outlet right ventricle (HP:0001719)	2.24863184
48	Congenital malformation of the right heart (HP:0011723)	2.24863184
49	Hypomagnesemia (HP:0002917)	2.23843044
50	Hepatic necrosis (HP:0002605)	2.22973150
51	Sclerocornea (HP:0000647)	2.22758418
52	Prolonged QT interval (HP:0001657)	2.21887959
53	Facial diplegia (HP:0001349)	2.21347542
54	Ventricular fibrillation (HP:0001663)	2.21139627
55	Leukodystrophy (HP:0002415)	2.18627131
56	Azoospermia (HP:0000027)	2.18443341
57	Abnormality of B cell number (HP:0010975)	2.18153596
58	Supernumerary spleens (HP:0009799)	2.16004115
59	Myokymia (HP:0002411)	2.15249199
60	Pallor (HP:0000980)	2.14607928
61	Abnormal ciliary motility (HP:0012262)	2.13934258
62	B lymphocytopenia (HP:0010976)	2.12352651
63	Type 2 muscle fiber atrophy (HP:0003554)	2.10823804
64	Polydipsia (HP:0001959)	2.10341009
65	Abnormal drinking behavior (HP:0030082)	2.10341009
66	Abnormality of urine glucose concentration (HP:0011016)	2.06104001
67	Glycosuria (HP:0003076)	2.06104001
68	Abnormal hemoglobin (HP:0011902)	2.03251732
69	Maternal diabetes (HP:0009800)	2.02302711
70	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.01176561
71	Thrombocytosis (HP:0001894)	2.00942994
72	Absent septum pellucidum (HP:0001331)	2.00886600
73	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.00204023
74	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.99858907
75	Rhinitis (HP:0012384)	1.98437961
76	Impulsivity (HP:0100710)	1.96420978
77	Abnormality of renal resorption (HP:0011038)	1.96331845
78	Pancreatic fibrosis (HP:0100732)	1.91475240
79	Optic disc pallor (HP:0000543)	1.90389098
80	Exercise intolerance (HP:0003546)	1.89643500
81	Confusion (HP:0001289)	1.88903877
82	Abnormal respiratory epithelium morphology (HP:0012253)	1.87014365
83	Abnormal respiratory motile cilium morphology (HP:0005938)	1.87014365
84	Pancreatic cysts (HP:0001737)	1.86356576
85	Muscle fiber atrophy (HP:0100295)	1.85404550
86	Growth hormone deficiency (HP:0000824)	1.84120832
87	Hypoplasia of the ulna (HP:0003022)	1.83671022
88	Partial duplication of thumb phalanx (HP:0009944)	1.83218601
89	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.81603699
90	Increased corneal curvature (HP:0100692)	1.80651295
91	Keratoconus (HP:0000563)	1.80651295
92	Increased serum lactate (HP:0002151)	1.79223022
93	Abnormality of methionine metabolism (HP:0010901)	1.78318506
94	Diplopia (HP:0000651)	1.77638418
95	Abnormality of binocular vision (HP:0011514)	1.77638418
96	Premature ovarian failure (HP:0008209)	1.77548757
97	Erythroderma (HP:0001019)	1.76476517
98	Triphalangeal thumb (HP:0001199)	1.76298561
99	Methylmalonic acidemia (HP:0002912)	1.74386621
100	Polyuria (HP:0000103)	1.74288394

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	5.86561591
2	TLK1	3.24732354
3	BMPR1B	2.75659720
4	TAOK1	2.63180397
5	FRK	2.38190810
6	TNIK	2.28392268
7	KDR	2.10242643
8	TAOK3	2.06735876
9	DYRK2	2.01647380
10	PINK1	1.98912158
11	LIMK1	1.90063617
12	ADRBK2	1.87108633
13	WNK4	1.85593613
14	GRK1	1.83164182
15	CDC7	1.57325998
16	MAP3K9	1.56556615
17	NME2	1.53807947
18	CDK19	1.49158269
19	CAMK1D	1.42972974
20	EIF2AK1	1.41830334
21	MKNK2	1.33417083
22	NME1	1.31354532
23	MAP3K12	1.26534826
24	MYLK	1.23983372
25	BMPR2	1.23208042
26	MAPK13	1.20969301
27	WNK1	1.14337172
28	ILK	1.14268745
29	TIE1	1.14063965
30	ITK	1.13519731
31	MAP2K7	1.13243682
32	MAP3K4	1.07180323
33	BRAF	1.05384702
34	ROCK1	1.03873681
35	ARAF	0.94084482
36	CDK8	0.93553239
37	BCKDK	0.91871156
38	PRKCG	0.91859083
39	CAMK1G	0.90885625
40	LRRK2	0.89699338
41	NTRK2	0.89236781
42	STK38L	0.86676737
43	PIM1	0.86512790
44	CAMK1	0.83405938
45	AKT3	0.80931758
46	TESK2	0.80327677
47	ERBB3	0.79986073
48	TEC	0.75519230
49	TGFBR1	0.75383264
50	INSRR	0.74726825
51	VRK1	0.74226417
52	PIK3CA	0.74210028
53	DAPK3	0.73997283
54	OBSCN	0.73703133
55	ZAK	0.72037843
56	STK39	0.70906388
57	TXK	0.68920864
58	TRIM28	0.66905776
59	PRKACA	0.66076459
60	OXSR1	0.65813911
61	STK11	0.65746773
62	TRPM7	0.63602181
63	VRK2	0.63520605
64	ATR	0.63499709
65	MARK1	0.62590417
66	PHKG2	0.62299876
67	PHKG1	0.62299876
68	WNK3	0.59288836
69	PRKCD	0.57306663
70	AURKA	0.55561425
71	CSNK2A2	0.54761769
72	PRKACB	0.54201842
73	ATM	0.53582522
74	STK3	0.53176465
75	CAMK2A	0.52167546
76	PRKCA	0.52117160
77	GRK7	0.51103653
78	ADRBK1	0.50794877
79	PAK1	0.50646010
80	CSNK2A1	0.49968966
81	MST4	0.49926719
82	AURKB	0.48416645
83	PAK3	0.47732773
84	CSNK1A1	0.47528779
85	PRKDC	0.45751002
86	DAPK2	0.45011044
87	PLK4	0.44892699
88	MKNK1	0.44546624
89	CHEK2	0.44542995
90	CSNK1G2	0.44003541
91	CAMK2D	0.42128955
92	BTK	0.41893167
93	PRKCE	0.41399355
94	ACVR1B	0.41241003
95	PRKCQ	0.40932550
96	EPHA4	0.40653059
97	CSNK1D	0.38976653
98	TAF1	0.38303759
99	PRKG1	0.37951715
100	RPS6KA3	0.37580256

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.26949999
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.61931320
3	Parkinsons disease_Homo sapiens_hsa05012	3.96638717
4	Protein export_Homo sapiens_hsa03060	3.06216630
5	Huntingtons disease_Homo sapiens_hsa05016	3.04162073
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.97132869
7	Alzheimers disease_Homo sapiens_hsa05010	2.68474394
8	Proteasome_Homo sapiens_hsa03050	2.64273118
9	RNA polymerase_Homo sapiens_hsa03020	2.34577755
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.28390157
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.12200625
12	DNA replication_Homo sapiens_hsa03030	2.10508651
13	Linoleic acid metabolism_Homo sapiens_hsa00591	2.02024046
14	Homologous recombination_Homo sapiens_hsa03440	2.01998772
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.91101651
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.79175855
17	Asthma_Homo sapiens_hsa05310	1.68730141
18	Fatty acid elongation_Homo sapiens_hsa00062	1.50961061
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.40313546
20	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.38311129
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.32958801
22	Mismatch repair_Homo sapiens_hsa03430	1.21247089
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17747888
24	Basal transcription factors_Homo sapiens_hsa03022	1.15142740
25	Phototransduction_Homo sapiens_hsa04744	1.14403628
26	Nicotine addiction_Homo sapiens_hsa05033	1.10725535
27	Propanoate metabolism_Homo sapiens_hsa00640	1.10098902
28	Pyrimidine metabolism_Homo sapiens_hsa00240	1.08946135
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.07083661
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.00359076
31	Non-homologous end-joining_Homo sapiens_hsa03450	0.99425548
32	Graft-versus-host disease_Homo sapiens_hsa05332	0.98969371
33	Caffeine metabolism_Homo sapiens_hsa00232	0.98782524
34	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.97891724
35	Fanconi anemia pathway_Homo sapiens_hsa03460	0.94159733
36	Fat digestion and absorption_Homo sapiens_hsa04975	0.92831398
37	One carbon pool by folate_Homo sapiens_hsa00670	0.91529472
38	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.89367751
39	Fatty acid metabolism_Homo sapiens_hsa01212	0.87900730
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.87282410
41	Primary immunodeficiency_Homo sapiens_hsa05340	0.86314415
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85456385
43	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.84492086
44	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.82149767
45	Antigen processing and presentation_Homo sapiens_hsa04612	0.80628079
46	Purine metabolism_Homo sapiens_hsa00230	0.79851934
47	Butanoate metabolism_Homo sapiens_hsa00650	0.77381942
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.77168658
49	Folate biosynthesis_Homo sapiens_hsa00790	0.76166115
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75747056
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.75695437
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.75395626
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72738020
54	RNA degradation_Homo sapiens_hsa03018	0.72091145
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.70743771
56	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.69305646
57	Metabolic pathways_Homo sapiens_hsa01100	0.65505799
58	Type I diabetes mellitus_Homo sapiens_hsa04940	0.64343617
59	Peroxisome_Homo sapiens_hsa04146	0.64024239
60	Serotonergic synapse_Homo sapiens_hsa04726	0.63677195
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61723069
62	Selenocompound metabolism_Homo sapiens_hsa00450	0.61550608
63	Retinol metabolism_Homo sapiens_hsa00830	0.61361821
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.58969698
65	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.58837078
66	Spliceosome_Homo sapiens_hsa03040	0.57562040
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.56615223
68	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.55636488
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.55464151
70	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.55094259
71	Allograft rejection_Homo sapiens_hsa05330	0.54072568
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.53716272
73	Mineral absorption_Homo sapiens_hsa04978	0.53439538
74	Gastric acid secretion_Homo sapiens_hsa04971	0.52236062
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.51620650
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.50111629
77	Olfactory transduction_Homo sapiens_hsa04740	0.47046956
78	RNA transport_Homo sapiens_hsa03013	0.46973165
79	Basal cell carcinoma_Homo sapiens_hsa05217	0.46950050
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45770694
81	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.44314871
82	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.43139622
83	Fatty acid degradation_Homo sapiens_hsa00071	0.42479572
84	Amphetamine addiction_Homo sapiens_hsa05031	0.40351327
85	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.40216385
86	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.39790221
87	Insulin secretion_Homo sapiens_hsa04911	0.39043198
88	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.38523640
89	Glutamatergic synapse_Homo sapiens_hsa04724	0.37095619
90	Tryptophan metabolism_Homo sapiens_hsa00380	0.36850108
91	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.35417950
92	Morphine addiction_Homo sapiens_hsa05032	0.33278008
93	Collecting duct acid secretion_Homo sapiens_hsa04966	0.32725032
94	Taste transduction_Homo sapiens_hsa04742	0.32520956
95	GABAergic synapse_Homo sapiens_hsa04727	0.31557648
96	cAMP signaling pathway_Homo sapiens_hsa04024	0.30876782
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.30066210
98	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.28330462
99	Tyrosine metabolism_Homo sapiens_hsa00350	0.26448038
100	Wnt signaling pathway_Homo sapiens_hsa04310	0.25336357

UQCRBP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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