

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | tricarboxylic acid cycle (GO:0006099) | 8.09867854 |
| 2 | NADH metabolic process (GO:0006734) | 6.53729629 |
| 3 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 5.56370474 |
| 4 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.45557925 |
| 5 | sarcomere organization (GO:0045214) | 5.41343537 |
| 6 | * oxidative phosphorylation (GO:0006119) | 5.28201656 |
| 7 | lysine catabolic process (GO:0006554) | 5.14534084 |
| 8 | lysine metabolic process (GO:0006553) | 5.14534084 |
| 9 | oxaloacetate metabolic process (GO:0006107) | 5.06614492 |
| 10 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 4.97931570 |
| 11 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.82375530 |
| 12 | ATP synthesis coupled proton transport (GO:0015986) | 4.82375530 |
| 13 | regulation of coenzyme metabolic process (GO:0051196) | 4.81792522 |
| 14 | regulation of cofactor metabolic process (GO:0051193) | 4.81792522 |
| 15 | cardiac myofibril assembly (GO:0055003) | 4.72489840 |
| 16 | 2-oxoglutarate metabolic process (GO:0006103) | 4.64967324 |
| 17 | succinate metabolic process (GO:0006105) | 4.64009797 |
| 18 | muscle filament sliding (GO:0030049) | 4.61374228 |
| 19 | actin-myosin filament sliding (GO:0033275) | 4.61374228 |
| 20 | carnitine shuttle (GO:0006853) | 4.61206708 |
| 21 | aspartate family amino acid catabolic process (GO:0009068) | 4.42372518 |
| 22 | tricarboxylic acid metabolic process (GO:0072350) | 4.34390857 |
| 23 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.17817559 |
| 24 | * respiratory electron transport chain (GO:0022904) | 4.13599386 |
| 25 | myofibril assembly (GO:0030239) | 4.12866269 |
| 26 | cardiac muscle contraction (GO:0060048) | 4.11945915 |
| 27 | fatty acid transmembrane transport (GO:1902001) | 4.11264030 |
| 28 | * electron transport chain (GO:0022900) | 4.03150948 |
| 29 | branched-chain amino acid catabolic process (GO:0009083) | 4.01903582 |
| 30 | proteasome assembly (GO:0043248) | 4.00994085 |
| 31 | fatty acid beta-oxidation (GO:0006635) | 3.99408358 |
| 32 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.89712521 |
| 33 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.88646426 |
| 34 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.88008390 |
| 35 | negative regulation of ligase activity (GO:0051352) | 3.88008390 |
| 36 | cullin deneddylation (GO:0010388) | 3.87923416 |
| 37 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.82943254 |
| 38 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 3.82020404 |
| 39 | heart process (GO:0003015) | 3.80884220 |
| 40 | heart contraction (GO:0060047) | 3.80884220 |
| 41 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.78251290 |
| 42 | protein maturation by protein folding (GO:0022417) | 3.76945574 |
| 43 | establishment of integrated proviral latency (GO:0075713) | 3.76639270 |
| 44 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.75188170 |
| 45 | regulation of sulfur metabolic process (GO:0042762) | 3.73220498 |
| 46 | cardiac muscle cell development (GO:0055013) | 3.71506466 |
| 47 | L-serine metabolic process (GO:0006563) | 3.69159217 |
| 48 | quinone biosynthetic process (GO:1901663) | 3.67469703 |
| 49 | ubiquinone biosynthetic process (GO:0006744) | 3.67469703 |
| 50 | branched-chain amino acid metabolic process (GO:0009081) | 3.61447952 |
| 51 | protein deneddylation (GO:0000338) | 3.61009051 |
| 52 | carnitine transmembrane transport (GO:1902603) | 3.59769621 |
| 53 | actin-mediated cell contraction (GO:0070252) | 3.58029145 |
| 54 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 3.55349928 |
| 55 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 3.53727500 |
| 56 | carnitine transport (GO:0015879) | 3.53478368 |
| 57 | amino-acid betaine transport (GO:0015838) | 3.53478368 |
| 58 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.52908850 |
| 59 | regulation of skeletal muscle contraction (GO:0014819) | 3.50760591 |
| 60 | ATP biosynthetic process (GO:0006754) | 3.48402036 |
| 61 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.47099272 |
| 62 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.47099272 |
| 63 | valine metabolic process (GO:0006573) | 3.46867036 |
| 64 | gluconeogenesis (GO:0006094) | 3.46852164 |
| 65 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.44206399 |
| 66 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.44206399 |
| 67 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.44206399 |
| 68 | cardiac cell development (GO:0055006) | 3.43526537 |
| 69 | galactose catabolic process (GO:0019388) | 3.43275895 |
| 70 | regulation of fatty acid oxidation (GO:0046320) | 3.39120265 |
| 71 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.38486362 |
| 72 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.38486362 |
| 73 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 3.36550898 |
| 74 | establishment of viral latency (GO:0019043) | 3.33633676 |
| 75 | fatty acid catabolic process (GO:0009062) | 3.33061474 |
| 76 | hexose biosynthetic process (GO:0019319) | 3.32583869 |
| 77 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.32525990 |
| 78 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 3.32478858 |
| 79 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 3.32478858 |
| 80 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 3.31430660 |
| 81 | ventricular cardiac muscle cell action potential (GO:0086005) | 3.31075627 |
| 82 | fatty acid oxidation (GO:0019395) | 3.29600975 |
| 83 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.29372525 |
| 84 | actomyosin structure organization (GO:0031032) | 3.29354373 |
| 85 | carnitine metabolic process (GO:0009437) | 3.29249448 |
| 86 | acetyl-CoA metabolic process (GO:0006084) | 3.28923787 |
| 87 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.28169280 |
| 88 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 3.27184823 |
| 89 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.25854163 |
| 90 | lipid oxidation (GO:0034440) | 3.22604386 |
| 91 | cardiac muscle tissue morphogenesis (GO:0055008) | 3.22152611 |
| 92 | striated muscle contraction (GO:0006941) | 3.21938417 |
| 93 | protein targeting to mitochondrion (GO:0006626) | 3.19905648 |
| 94 | proline biosynthetic process (GO:0006561) | 3.19120580 |
| 95 | regulation of sequestering of triglyceride (GO:0010889) | 3.17697800 |
| 96 | chaperone-mediated protein transport (GO:0072321) | 3.15959967 |
| 97 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.14458213 |
| 98 | DNA strand elongation (GO:0022616) | 3.14332481 |
| 99 | positive regulation of ligase activity (GO:0051351) | 3.12364495 |
| 100 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 3.11715751 |
| 101 | mitochondrial fusion (GO:0008053) | 3.11174245 |
| 102 | cardiac muscle hypertrophy (GO:0003300) | 3.11102836 |
| 103 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.08870734 |
| 104 | monosaccharide biosynthetic process (GO:0046364) | 3.08703408 |
| 105 | ubiquinone metabolic process (GO:0006743) | 3.07519442 |
| 106 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.07286421 |
| 107 | AMP metabolic process (GO:0046033) | 3.07248010 |
| 108 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 3.06757979 |
| 109 | regulation of relaxation of muscle (GO:1901077) | 3.06732729 |
| 110 | glyoxylate metabolic process (GO:0046487) | 3.06385306 |
| 111 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 3.06061132 |
| 112 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.05013425 |
| 113 | IMP biosynthetic process (GO:0006188) | 3.04571203 |
| 114 | IMP metabolic process (GO:0046040) | 3.03635897 |
| 115 | nucleoside diphosphate biosynthetic process (GO:0009133) | 3.02131977 |
| 116 | biotin metabolic process (GO:0006768) | 3.01406261 |
| 117 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.01033566 |
| 118 | plasma membrane repair (GO:0001778) | 2.99286391 |
| 119 | regulation of actin filament-based movement (GO:1903115) | 2.96659392 |
| 120 | ribonucleoside monophosphate biosynthetic process (GO:0009156) | 2.96486175 |
| 121 | regulation of ligase activity (GO:0051340) | 2.96331083 |
| 122 | purine nucleobase biosynthetic process (GO:0009113) | 2.96068610 |
| 123 | regulation of mitochondrial translation (GO:0070129) | 2.95875083 |
| 124 | regulation of cellular amine metabolic process (GO:0033238) | 2.93514006 |
| 125 | striated muscle hypertrophy (GO:0014897) | 2.93269450 |
| 126 | amino-acid betaine metabolic process (GO:0006577) | 2.92629335 |
| 127 | histone arginine methylation (GO:0034969) | 2.92478418 |
| 128 | pyruvate metabolic process (GO:0006090) | 2.92080684 |
| 129 | cellular ketone body metabolic process (GO:0046950) | 2.91487838 |
| 130 | establishment of protein localization to mitochondrion (GO:0072655) | 2.91406585 |
| 131 | nucleobase biosynthetic process (GO:0046112) | 2.90343812 |
| 132 | aldehyde catabolic process (GO:0046185) | 2.89431603 |
| 133 | quaternary ammonium group transport (GO:0015697) | 2.87267980 |
| 134 | inner mitochondrial membrane organization (GO:0007007) | 2.87192586 |
| 135 | protein localization to mitochondrion (GO:0070585) | 2.86448367 |
| 136 | glycolytic process (GO:0006096) | 2.86382591 |
| 137 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 2.85747575 |
| 138 | monocarboxylic acid catabolic process (GO:0072329) | 2.85579726 |
| 139 | muscle tissue morphogenesis (GO:0060415) | 2.85422977 |
| 140 | regulation of ATPase activity (GO:0043462) | 2.85061147 |
| 141 | regulation of ATP catabolic process (GO:1903289) | 2.85061147 |
| 142 | tRNA aminoacylation for protein translation (GO:0006418) | 2.84981299 |
| 143 | protein complex biogenesis (GO:0070271) | 2.84259648 |
| 144 | * aerobic respiration (GO:0009060) | 2.83903491 |
| 145 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.83415902 |
| 146 | heart trabecula formation (GO:0060347) | 2.83114403 |
| 147 | nucleoside monophosphate biosynthetic process (GO:0009124) | 2.82711248 |
| 148 | NADPH regeneration (GO:0006740) | 2.81085412 |
| 149 | short-chain fatty acid metabolic process (GO:0046459) | 2.80968969 |
| 150 | fatty acid homeostasis (GO:0055089) | 2.80427326 |
| 151 | formation of translation preinitiation complex (GO:0001731) | 2.80043871 |
| 152 | ventricular cardiac muscle cell development (GO:0055015) | 2.77865728 |
| 153 | GDP-mannose metabolic process (GO:0019673) | 2.75743461 |
| 154 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.74435138 |
| 155 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.74257562 |
| 156 | tRNA aminoacylation (GO:0043039) | 2.73937960 |
| 157 | amino acid activation (GO:0043038) | 2.73937960 |
| 158 | creatine metabolic process (GO:0006600) | 2.70452255 |
| 159 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 2.67455654 |
| 160 | mitochondrial transport (GO:0006839) | 2.66235347 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 5.54145510 |
| 2 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.44802096 |
| 3 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 3.54605823 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.42932175 |
| 5 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 3.08556655 |
| 6 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.01492736 |
| 7 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.90428428 |
| 8 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.90075535 |
| 9 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.89530320 |
| 10 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.89479888 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.70288072 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.57863060 |
| 13 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.51778064 |
| 14 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.51504471 |
| 15 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.27513660 |
| 16 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 2.24938182 |
| 17 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.21932396 |
| 18 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.11822592 |
| 19 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.08677817 |
| 20 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.05864229 |
| 21 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 2.01916204 |
| 22 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.01722892 |
| 23 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.96671421 |
| 24 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.90711638 |
| 25 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.87368343 |
| 26 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.86266052 |
| 27 | * YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.81768223 |
| 28 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.80246523 |
| 29 | * NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.77985869 |
| 30 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.73569400 |
| 31 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.70010674 |
| 32 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.66018524 |
| 33 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.63185991 |
| 34 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.60133751 |
| 35 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.56010635 |
| 36 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.55802243 |
| 37 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.53859175 |
| 38 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.52153816 |
| 39 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.52089103 |
| 40 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.50270513 |
| 41 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.50208489 |
| 42 | * PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.49411389 |
| 43 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.45403974 |
| 44 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.41927128 |
| 45 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.40799425 |
| 46 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.40645796 |
| 47 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.40538529 |
| 48 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.39882733 |
| 49 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.39588255 |
| 50 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.38880632 |
| 51 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.36262091 |
| 52 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.35574600 |
| 53 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.34951587 |
| 54 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.34910188 |
| 55 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.34346650 |
| 56 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 1.33117449 |
| 57 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.29869644 |
| 58 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.29777586 |
| 59 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.29179245 |
| 60 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.28671888 |
| 61 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.25349883 |
| 62 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.24625281 |
| 63 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.24542399 |
| 64 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.24363349 |
| 65 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.23257646 |
| 66 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.20685085 |
| 67 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.20406086 |
| 68 | * BCL6_27268052_Chip-Seq_Bcells_Human | 1.19485701 |
| 69 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.18973842 |
| 70 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.18904758 |
| 71 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.18749254 |
| 72 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.18621625 |
| 73 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 1.17943207 |
| 74 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.17688030 |
| 75 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.16294908 |
| 76 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.15148626 |
| 77 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.14832235 |
| 78 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.14753084 |
| 79 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.13354005 |
| 80 | MYC_22102868_ChIP-Seq_BL_Human | 1.12901340 |
| 81 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.12802820 |
| 82 | P68_20966046_ChIP-Seq_HELA_Human | 1.12203339 |
| 83 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.11656434 |
| 84 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.11402063 |
| 85 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.08812804 |
| 86 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.08591040 |
| 87 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.08252009 |
| 88 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.07373300 |
| 89 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.06015939 |
| 90 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.05981303 |
| 91 | ATF3_27146783_Chip-Seq_COLON_Human | 1.04729461 |
| 92 | * CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.04301104 |
| 93 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.03057084 |
| 94 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.01968390 |
| 95 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.01770898 |
| 96 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.01770898 |
| 97 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.01442200 |
| 98 | * BCOR_27268052_Chip-Seq_Bcells_Human | 1.00769502 |
| 99 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.00647114 |
| 100 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.00578390 |
| 101 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.00531536 |
| 102 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.00292248 |
| 103 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.99668362 |
| 104 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.98420203 |
| 105 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.98050123 |
| 106 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.97491252 |
| 107 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.97414640 |
| 108 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.96970613 |
| 109 | * OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.96411727 |
| 110 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.96127413 |
| 111 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.95593090 |
| 112 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.95104452 |
| 113 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.94914216 |
| 114 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.94757223 |
| 115 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.94361964 |
| 116 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.93963992 |
| 117 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.93220288 |
| 118 | * CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.91762444 |
| 119 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.90722729 |
| 120 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.90290614 |
| 121 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.90063989 |
| 122 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.86452229 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003646_muscle_fatigue | 5.22541079 |
| 2 | MP0002837_dystrophic_cardiac_calcinosis | 5.11735577 |
| 3 | MP0004084_abnormal_cardiac_muscle | 4.55568114 |
| 4 | MP0000751_myopathy | 3.96433304 |
| 5 | MP0004215_abnormal_myocardial_fiber | 3.74285502 |
| 6 | MP0003806_abnormal_nucleotide_metabolis | 3.64008920 |
| 7 | MP0000749_muscle_degeneration | 3.60022410 |
| 8 | MP0005330_cardiomyopathy | 3.39821718 |
| 9 | MP0004036_abnormal_muscle_relaxation | 3.34914173 |
| 10 | MP0006036_abnormal_mitochondrial_physio | 3.21866592 |
| 11 | MP0000372_irregular_coat_pigmentation | 2.62367189 |
| 12 | MP0004087_abnormal_muscle_fiber | 2.49738781 |
| 13 | MP0010030_abnormal_orbit_morphology | 2.47750827 |
| 14 | MP0002269_muscular_atrophy | 2.47683506 |
| 15 | MP0002972_abnormal_cardiac_muscle | 2.37040711 |
| 16 | MP0004130_abnormal_muscle_cell | 2.31718682 |
| 17 | MP0008775_abnormal_heart_ventricle | 2.29267549 |
| 18 | MP0000750_abnormal_muscle_regeneration | 2.26577595 |
| 19 | MP0005360_urolithiasis | 2.25811878 |
| 20 | MP0003221_abnormal_cardiomyocyte_apopto | 2.17661267 |
| 21 | MP0008058_abnormal_DNA_repair | 2.16462479 |
| 22 | MP0005385_cardiovascular_system_phenoty | 2.16177237 |
| 23 | MP0001544_abnormal_cardiovascular_syste | 2.16177237 |
| 24 | MP0005620_abnormal_muscle_contractility | 2.12088634 |
| 25 | MP0006035_abnormal_mitochondrial_morpho | 2.10154638 |
| 26 | MP0008932_abnormal_embryonic_tissue | 2.09236429 |
| 27 | MP0008260_abnormal_autophagy | 2.08506830 |
| 28 | MP0005670_abnormal_white_adipose | 2.06609105 |
| 29 | MP0010630_abnormal_cardiac_muscle | 1.99921097 |
| 30 | MP0003137_abnormal_impulse_conducting | 1.99216251 |
| 31 | MP0002106_abnormal_muscle_physiology | 1.91978255 |
| 32 | MP0006138_congestive_heart_failure | 1.89413695 |
| 33 | MP0005085_abnormal_gallbladder_physiolo | 1.87333867 |
| 34 | MP0000747_muscle_weakness | 1.85026497 |
| 35 | MP0002139_abnormal_hepatobiliary_system | 1.81755364 |
| 36 | MP0004233_abnormal_muscle_weight | 1.78510908 |
| 37 | MP0009840_abnormal_foam_cell | 1.77690107 |
| 38 | MP0005332_abnormal_amino_acid | 1.68564345 |
| 39 | MP0004147_increased_porphyrin_level | 1.65264894 |
| 40 | MP0005365_abnormal_bile_salt | 1.64033756 |
| 41 | MP0000759_abnormal_skeletal_muscle | 1.60381534 |
| 42 | MP0005408_hypopigmentation | 1.55632799 |
| 43 | MP0005266_abnormal_metabolism | 1.55369140 |
| 44 | MP0005666_abnormal_adipose_tissue | 1.52795911 |
| 45 | MP0001661_extended_life_span | 1.52137080 |
| 46 | MP0004484_altered_response_of | 1.51051425 |
| 47 | MP0005369_muscle_phenotype | 1.48687953 |
| 48 | MP0002332_abnormal_exercise_endurance | 1.44034723 |
| 49 | MP0005319_abnormal_enzyme/_coenzyme | 1.43905185 |
| 50 | MP0003186_abnormal_redox_activity | 1.42154433 |
| 51 | MP0003718_maternal_effect | 1.34914533 |
| 52 | MP0004145_abnormal_muscle_electrophysio | 1.32805530 |
| 53 | MP0004085_abnormal_heartbeat | 1.31988150 |
| 54 | MP0003693_abnormal_embryo_hatching | 1.31543698 |
| 55 | MP0002127_abnormal_cardiovascular_syste | 1.29199150 |
| 56 | MP0003941_abnormal_skin_development | 1.28218570 |
| 57 | MP0004043_abnormal_pH_regulation | 1.25950238 |
| 58 | MP0003136_yellow_coat_color | 1.24911572 |
| 59 | MP0010329_abnormal_lipoprotein_level | 1.23670912 |
| 60 | MP0008007_abnormal_cellular_replicative | 1.22496210 |
| 61 | MP0003656_abnormal_erythrocyte_physiolo | 1.19476686 |
| 62 | MP0003828_pulmonary_edema | 1.15674257 |
| 63 | MP0004957_abnormal_blastocyst_morpholog | 1.15095368 |
| 64 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.13181274 |
| 65 | MP0005171_absent_coat_pigmentation | 1.12835772 |
| 66 | MP0002090_abnormal_vision | 1.11834222 |
| 67 | MP0001764_abnormal_homeostasis | 1.10968211 |
| 68 | MP0008875_abnormal_xenobiotic_pharmacok | 1.08608623 |
| 69 | MP0003567_abnormal_fetal_cardiomyocyte | 1.08163043 |
| 70 | MP0001529_abnormal_vocalization | 1.05407621 |
| 71 | MP0003786_premature_aging | 1.04242742 |
| 72 | MP0000343_altered_response_to | 1.02739464 |
| 73 | MP0002938_white_spotting | 1.02680836 |
| 74 | MP0009643_abnormal_urine_homeostasis | 1.02307153 |
| 75 | MP0005058_abnormal_lysosome_morphology | 1.02082939 |
| 76 | MP0005083_abnormal_biliary_tract | 1.00497612 |
| 77 | MP0003705_abnormal_hypodermis_morpholog | 0.99758264 |
| 78 | MP0001727_abnormal_embryo_implantation | 0.94439322 |
| 79 | MP0000358_abnormal_cell_content/ | 0.94070536 |
| 80 | MP0003191_abnormal_cellular_cholesterol | 0.94008496 |
| 81 | MP0003195_calcinosis | 0.93451451 |
| 82 | MP0005375_adipose_tissue_phenotype | 0.88543498 |
| 83 | MP0004272_abnormal_basement_membrane | 0.88164483 |
| 84 | MP0000266_abnormal_heart_morphology | 0.87739574 |
| 85 | MP0002118_abnormal_lipid_homeostasis | 0.87489338 |
| 86 | MP0005165_increased_susceptibility_to | 0.86014511 |
| 87 | MP0000609_abnormal_liver_physiology | 0.82105740 |
| 88 | MP0001666_abnormal_nutrient_absorption | 0.81550831 |
| 89 | MP0001730_embryonic_growth_arrest | 0.81105593 |
| 90 | MP0000230_abnormal_systemic_arterial | 0.80606161 |
| 91 | MP0008789_abnormal_olfactory_epithelium | 0.79118604 |
| 92 | MP0005376_homeostasis/metabolism_phenot | 0.78132300 |
| 93 | MP0009672_abnormal_birth_weight | 0.78053824 |
| 94 | MP0002971_abnormal_brown_adipose | 0.78009945 |
| 95 | MP0003077_abnormal_cell_cycle | 0.75610228 |
| 96 | MP0003111_abnormal_nucleus_morphology | 0.75368610 |
| 97 | MP0001756_abnormal_urination | 0.75329216 |
| 98 | MP0003984_embryonic_growth_retardation | 0.75288532 |
| 99 | MP0002078_abnormal_glucose_homeostasis | 0.75254888 |
| 100 | MP0005257_abnormal_intraocular_pressure | 0.73725982 |
| 101 | MP0002088_abnormal_embryonic_growth/wei | 0.72595729 |
| 102 | MP0003123_paternal_imprinting | 0.72271251 |
| 103 | MP0001849_ear_inflammation | 0.70842695 |
| 104 | MP0000013_abnormal_adipose_tissue | 0.70332872 |
| 105 | MP0005636_abnormal_mineral_homeostasis | 0.67979302 |
| 106 | MP0000579_abnormal_nail_morphology | 0.66740134 |
| 107 | MP0001853_heart_inflammation | 0.66462610 |
| 108 | MP0010094_abnormal_chromosome_stability | 0.65830269 |
| 109 | MP0010234_abnormal_vibrissa_follicle | 0.65599147 |
| 110 | MP0002970_abnormal_white_adipose | 0.65442458 |
| 111 | MP0000598_abnormal_liver_morphology | 0.63744682 |
| 112 | MP0003566_abnormal_cell_adhesion | 0.62104327 |
| 113 | MP0002877_abnormal_melanocyte_morpholog | 0.61852747 |
| 114 | MP0002234_abnormal_pharynx_morphology | 0.61515256 |
| 115 | MP0002102_abnormal_ear_morphology | 0.61075020 |
| 116 | MP0001984_abnormal_olfaction | 0.61020858 |
| 117 | MP0003252_abnormal_bile_duct | 0.60450995 |
| 118 | MP0000537_abnormal_urethra_morphology | 0.59860695 |
| 119 | MP0000313_abnormal_cell_death | 0.59851305 |
| 120 | MP0009697_abnormal_copulation | 0.59685162 |
| 121 | MP0001672_abnormal_embryogenesis/_devel | 0.59357292 |
| 122 | MP0005380_embryogenesis_phenotype | 0.59357292 |
| 123 | MP0005535_abnormal_body_temperature | 0.58961389 |
| 124 | MP0004019_abnormal_vitamin_homeostasis | 0.58527892 |
| 125 | MP0002080_prenatal_lethality | 0.57710048 |
| 126 | MP0003315_abnormal_perineum_morphology | 0.56462640 |
| 127 | MP0004185_abnormal_adipocyte_glucose | 0.55373712 |
| 128 | MP0005451_abnormal_body_composition | 0.55323863 |
| 129 | MP0002822_catalepsy | 0.54412664 |
| 130 | MP0005075_abnormal_melanosome_morpholog | 0.54402858 |
| 131 | MP0000762_abnormal_tongue_morphology | 0.54211240 |
| 132 | MP0003279_aneurysm | 0.51898947 |
| 133 | MP0004510_myositis | 0.51550378 |
| 134 | MP0001697_abnormal_embryo_size | 0.50666394 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myoglobinuria (HP:0002913) | 5.16067757 |
| 2 | Sudden death (HP:0001699) | 4.95540731 |
| 3 | Exercise-induced muscle cramps (HP:0003710) | 4.80379272 |
| 4 | Nemaline bodies (HP:0003798) | 4.75491412 |
| 5 | Hepatic necrosis (HP:0002605) | 4.60031968 |
| 6 | Rhabdomyolysis (HP:0003201) | 4.56765228 |
| 7 | Exercise-induced myalgia (HP:0003738) | 4.53966141 |
| 8 | Ventricular tachycardia (HP:0004756) | 4.48298076 |
| 9 | Palpitations (HP:0001962) | 4.19258594 |
| 10 | Hepatocellular necrosis (HP:0001404) | 4.01677189 |
| 11 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.99279289 |
| 12 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.96456110 |
| 13 | Abnormal gallbladder physiology (HP:0012438) | 3.87375201 |
| 14 | Cholecystitis (HP:0001082) | 3.87375201 |
| 15 | Calf muscle hypertrophy (HP:0008981) | 3.80327867 |
| 16 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 3.77829964 |
| 17 | Dicarboxylic aciduria (HP:0003215) | 3.77829964 |
| 18 | Acute necrotizing encephalopathy (HP:0006965) | 3.70603221 |
| 19 | Hypoglycemic coma (HP:0001325) | 3.68428774 |
| 20 | Acute encephalopathy (HP:0006846) | 3.62674555 |
| 21 | Lipoatrophy (HP:0100578) | 3.61907717 |
| 22 | Increased serum pyruvate (HP:0003542) | 3.57622214 |
| 23 | Abnormality of glycolysis (HP:0004366) | 3.57622214 |
| 24 | Ketoacidosis (HP:0001993) | 3.55138537 |
| 25 | Hyperglycinuria (HP:0003108) | 3.51210147 |
| 26 | Increased CSF lactate (HP:0002490) | 3.46339211 |
| 27 | Lactic acidosis (HP:0003128) | 3.39587284 |
| 28 | Muscle hypertrophy of the lower extremities (HP:0008968) | 3.38068163 |
| 29 | Muscle fiber splitting (HP:0003555) | 3.38032750 |
| 30 | Atrial fibrillation (HP:0005110) | 3.37487909 |
| 31 | Increased muscle lipid content (HP:0009058) | 3.35859240 |
| 32 | Hyperammonemia (HP:0001987) | 3.35746542 |
| 33 | Mitochondrial inheritance (HP:0001427) | 3.35436896 |
| 34 | Cerebral edema (HP:0002181) | 3.32762835 |
| 35 | Ragged-red muscle fibers (HP:0003200) | 3.32194134 |
| 36 | Generalized aminoaciduria (HP:0002909) | 3.27281914 |
| 37 | Right ventricular cardiomyopathy (HP:0011663) | 3.23495196 |
| 38 | Dilated cardiomyopathy (HP:0001644) | 3.17400269 |
| 39 | Supraventricular tachycardia (HP:0004755) | 3.17316657 |
| 40 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.13906406 |
| 41 | Abnormality of alanine metabolism (HP:0010916) | 3.13906406 |
| 42 | Hyperalaninemia (HP:0003348) | 3.13906406 |
| 43 | Ketosis (HP:0001946) | 3.12979744 |
| 44 | Primary atrial arrhythmia (HP:0001692) | 3.12502013 |
| 45 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.12306308 |
| 46 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.12306308 |
| 47 | Myopathic facies (HP:0002058) | 3.11884263 |
| 48 | Supraventricular arrhythmia (HP:0005115) | 3.10929208 |
| 49 | Abnormality of the calf musculature (HP:0001430) | 3.02176349 |
| 50 | Type 1 muscle fiber predominance (HP:0003803) | 3.02059946 |
| 51 | Increased serum lactate (HP:0002151) | 2.96177519 |
| 52 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.94189338 |
| 53 | Abnormality of glycine metabolism (HP:0010895) | 2.94189338 |
| 54 | Rimmed vacuoles (HP:0003805) | 2.92230505 |
| 55 | Asymmetric septal hypertrophy (HP:0001670) | 2.90655231 |
| 56 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 2.89629608 |
| 57 | Abnormality of the left ventricular outflow tract (HP:0011103) | 2.89572496 |
| 58 | Subaortic stenosis (HP:0001682) | 2.89572496 |
| 59 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.88079218 |
| 60 | Nausea (HP:0002018) | 2.87902254 |
| 61 | Progressive macrocephaly (HP:0004481) | 2.87412152 |
| 62 | Increased intramyocellular lipid droplets (HP:0012240) | 2.84492484 |
| 63 | Exercise intolerance (HP:0003546) | 2.83895803 |
| 64 | Distal lower limb muscle weakness (HP:0009053) | 2.82323684 |
| 65 | Ventricular arrhythmia (HP:0004308) | 2.81883154 |
| 66 | Microvesicular hepatic steatosis (HP:0001414) | 2.80971900 |
| 67 | Conjunctival hamartoma (HP:0100780) | 2.80763863 |
| 68 | Bundle branch block (HP:0011710) | 2.78647405 |
| 69 | Increased connective tissue (HP:0009025) | 2.77879541 |
| 70 | Neck muscle weakness (HP:0000467) | 2.77642953 |
| 71 | Type I transferrin isoform profile (HP:0003642) | 2.75520209 |
| 72 | Respiratory failure (HP:0002878) | 2.75383763 |
| 73 | Syncope (HP:0001279) | 2.74022619 |
| 74 | Neoplasm of the adrenal gland (HP:0100631) | 2.70136748 |
| 75 | Lethargy (HP:0001254) | 2.69300232 |
| 76 | Proximal tubulopathy (HP:0000114) | 2.66348275 |
| 77 | EMG: myopathic abnormalities (HP:0003458) | 2.65893409 |
| 78 | Ventricular fibrillation (HP:0001663) | 2.62773769 |
| 79 | Hyporeflexia of lower limbs (HP:0002600) | 2.62728299 |
| 80 | Multiple enchondromatosis (HP:0005701) | 2.62190880 |
| 81 | Muscle stiffness (HP:0003552) | 2.51544871 |
| 82 | Pheochromocytoma (HP:0002666) | 2.51202191 |
| 83 | Myotonia (HP:0002486) | 2.50330966 |
| 84 | Atrioventricular block (HP:0001678) | 2.47798288 |
| 85 | CNS demyelination (HP:0007305) | 2.45424541 |
| 86 | Metabolic acidosis (HP:0001942) | 2.43887729 |
| 87 | Gout (HP:0001997) | 2.43735305 |
| 88 | Esophageal neoplasm (HP:0100751) | 2.42397599 |
| 89 | Neoplasm of head and neck (HP:0012288) | 2.42397599 |
| 90 | Heart block (HP:0012722) | 2.41293063 |
| 91 | Hyperglycinemia (HP:0002154) | 2.36221734 |
| 92 | Neuroendocrine neoplasm (HP:0100634) | 2.35324847 |
| 93 | Prolonged QT interval (HP:0001657) | 2.32422828 |
| 94 | Progressive muscle weakness (HP:0003323) | 2.29183211 |
| 95 | Reduced antithrombin III activity (HP:0001976) | 2.29117970 |
| 96 | Difficulty climbing stairs (HP:0003551) | 2.28790646 |
| 97 | Cholelithiasis (HP:0001081) | 2.25387532 |
| 98 | Abnormal atrioventricular conduction (HP:0005150) | 2.24701998 |
| 99 | Vomiting (HP:0002013) | 2.19984988 |
| 100 | Cerebral hypomyelination (HP:0006808) | 2.19501729 |
| 101 | Lipid accumulation in hepatocytes (HP:0006561) | 2.19425939 |
| 102 | Increased hepatocellular lipid droplets (HP:0006565) | 2.19156910 |
| 103 | Difficulty running (HP:0009046) | 2.14664040 |
| 104 | Methylmalonic aciduria (HP:0012120) | 2.12969933 |
| 105 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.11827235 |
| 106 | Abnormal protein glycosylation (HP:0012346) | 2.11827235 |
| 107 | Abnormal glycosylation (HP:0012345) | 2.11827235 |
| 108 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.11827235 |
| 109 | Hypokinesia (HP:0002375) | 2.04849815 |
| 110 | Abnormality of serum amino acid levels (HP:0003112) | 2.03422450 |
| 111 | Muscle fiber inclusion bodies (HP:0100299) | 2.01637124 |
| 112 | Calcaneovalgus deformity (HP:0001848) | 1.99695950 |
| 113 | Angiofibromas (HP:0010615) | 1.98262502 |
| 114 | Adenoma sebaceum (HP:0009720) | 1.98262502 |
| 115 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 1.97445123 |
| 116 | Abnormal gallbladder morphology (HP:0012437) | 1.97221375 |
| 117 | Emotional lability (HP:0000712) | 1.96812733 |
| 118 | Limb-girdle muscle atrophy (HP:0003797) | 1.95936790 |
| 119 | Shoulder girdle muscle weakness (HP:0003547) | 1.95344139 |
| 120 | Abnormality of skeletal muscle fiber size (HP:0012084) | 1.95316030 |
| 121 | Distal lower limb amyotrophy (HP:0008944) | 1.93637680 |
| 122 | Degeneration of anterior horn cells (HP:0002398) | 1.93402774 |
| 123 | Abnormality of the anterior horn cell (HP:0006802) | 1.93402774 |
| 124 | Cerebral palsy (HP:0100021) | 1.93384244 |
| 125 | Leukodystrophy (HP:0002415) | 1.93019298 |
| 126 | Areflexia of lower limbs (HP:0002522) | 1.92873538 |
| 127 | Athetosis (HP:0002305) | 1.92743306 |
| 128 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.92392136 |
| 129 | Distal arthrogryposis (HP:0005684) | 1.92009991 |
| 130 | Opisthotonus (HP:0002179) | 1.89774373 |
| 131 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.88935819 |
| 132 | Renal Fanconi syndrome (HP:0001994) | 1.85203360 |
| 133 | Deformed tarsal bones (HP:0008119) | 1.84218232 |
| 134 | Optic disc pallor (HP:0000543) | 1.70547562 |
| 135 | Amniotic constriction ring (HP:0009775) | 1.68925031 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BCKDK | 4.80270486 |
| 2 | NEK1 | 4.60946480 |
| 3 | PDK4 | 4.22909357 |
| 4 | PDK3 | 4.22909357 |
| 5 | VRK2 | 4.05392148 |
| 6 | TTN | 3.50915159 |
| 7 | OBSCN | 3.35128457 |
| 8 | LMTK2 | 3.13831256 |
| 9 | MYLK | 2.99259745 |
| 10 | PKN2 | 2.96294603 |
| 11 | TRIB3 | 2.77032566 |
| 12 | PBK | 2.66994056 |
| 13 | BUB1 | 2.61678656 |
| 14 | PDK2 | 2.45706737 |
| 15 | PHKG2 | 2.39590232 |
| 16 | PHKG1 | 2.39590232 |
| 17 | EIF2AK1 | 2.16507840 |
| 18 | SRPK1 | 2.07591795 |
| 19 | KDR | 1.73115139 |
| 20 | PINK1 | 1.65430285 |
| 21 | SMG1 | 1.50364445 |
| 22 | MAPKAPK3 | 1.46630878 |
| 23 | MAP3K11 | 1.45687465 |
| 24 | WEE1 | 1.43268312 |
| 25 | NME1 | 1.38951378 |
| 26 | MAP2K3 | 1.31201512 |
| 27 | FLT3 | 1.29663247 |
| 28 | TESK1 | 1.28793707 |
| 29 | STK24 | 1.24213989 |
| 30 | CSNK1G3 | 1.23853633 |
| 31 | TRIM28 | 1.22933185 |
| 32 | TSSK6 | 1.20765551 |
| 33 | NME2 | 1.19721425 |
| 34 | TIE1 | 1.17510556 |
| 35 | CCNB1 | 1.15675644 |
| 36 | PLK3 | 1.14952765 |
| 37 | STK38L | 1.13838675 |
| 38 | ZAK | 1.13798973 |
| 39 | STK16 | 1.11877839 |
| 40 | ILK | 1.10757191 |
| 41 | MST1R | 1.10132498 |
| 42 | TESK2 | 1.04330063 |
| 43 | ERN1 | 0.97949483 |
| 44 | PIK3CA | 0.96189302 |
| 45 | PLK4 | 0.91509033 |
| 46 | CSNK1A1L | 0.91331498 |
| 47 | MAP3K12 | 0.88560345 |
| 48 | CSNK1G1 | 0.87866680 |
| 49 | SCYL2 | 0.84823221 |
| 50 | CDK8 | 0.83874305 |
| 51 | BRSK1 | 0.81999228 |
| 52 | TTK | 0.80708904 |
| 53 | MAP3K3 | 0.80505043 |
| 54 | DAPK3 | 0.79334979 |
| 55 | BRSK2 | 0.78987151 |
| 56 | CSNK1G2 | 0.78075648 |
| 57 | TAOK2 | 0.73654571 |
| 58 | MAP2K6 | 0.71238397 |
| 59 | MAP4K2 | 0.68924443 |
| 60 | MAPKAPK5 | 0.68798620 |
| 61 | LIMK1 | 0.67875009 |
| 62 | ATR | 0.67873779 |
| 63 | STK4 | 0.67685233 |
| 64 | CDK19 | 0.67604015 |
| 65 | MAP3K5 | 0.66532832 |
| 66 | MST4 | 0.63799665 |
| 67 | NEK2 | 0.62683061 |
| 68 | PAK4 | 0.62191204 |
| 69 | RPS6KB2 | 0.61314091 |
| 70 | MUSK | 0.61174840 |
| 71 | MAPK11 | 0.61039835 |
| 72 | WNK4 | 0.60899818 |
| 73 | EIF2AK3 | 0.60896397 |
| 74 | CDK7 | 0.60169075 |
| 75 | ACVR1B | 0.58730655 |
| 76 | PRKAA1 | 0.57898028 |
| 77 | MAPK12 | 0.56829784 |
| 78 | DYRK2 | 0.55954448 |
| 79 | NEK9 | 0.54590764 |
| 80 | AURKB | 0.54337677 |
| 81 | LRRK2 | 0.53470694 |
| 82 | ERBB4 | 0.52985940 |
| 83 | BRAF | 0.52862606 |
| 84 | PLK1 | 0.50795439 |
| 85 | TGFBR1 | 0.50225542 |
| 86 | CDK18 | 0.49779259 |
| 87 | TAF1 | 0.49455520 |
| 88 | PAK6 | 0.49139512 |
| 89 | DMPK | 0.48054877 |
| 90 | AKT2 | 0.47789359 |
| 91 | MET | 0.47737985 |
| 92 | CSNK2A1 | 0.47263731 |
| 93 | CDK11A | 0.47099136 |
| 94 | PIM2 | 0.46891625 |
| 95 | CDK4 | 0.46870111 |
| 96 | BCR | 0.46790830 |
| 97 | MAP3K10 | 0.46486875 |
| 98 | CDK14 | 0.46318487 |
| 99 | MAP3K8 | 0.46220172 |
| 100 | CDK15 | 0.46036879 |
| 101 | DAPK1 | 0.45756472 |
| 102 | CHEK2 | 0.44803580 |
| 103 | EPHA4 | 0.44470522 |
| 104 | SIK1 | 0.43894927 |
| 105 | AURKA | 0.43834297 |
| 106 | EPHB2 | 0.43641585 |
| 107 | EPHA2 | 0.43500178 |
| 108 | ERBB3 | 0.42735552 |
| 109 | RPS6KL1 | 0.41342106 |
| 110 | RPS6KC1 | 0.41342106 |
| 111 | CSNK2A2 | 0.41338606 |
| 112 | IRAK3 | 0.41156190 |
| 113 | WNK3 | 0.39831380 |
| 114 | PRKG2 | 0.39682631 |
| 115 | CDC7 | 0.39504695 |
| 116 | ARAF | 0.39049349 |
| 117 | CAMK2D | 0.38877589 |
| 118 | RIPK1 | 0.36972287 |
| 119 | PRKD3 | 0.36021600 |
| 120 | MAP2K7 | 0.35510872 |
| 121 | RPS6KA6 | 0.35506207 |
| 122 | ROCK1 | 0.33874359 |
| 123 | TAOK1 | 0.33494141 |
| 124 | ABL2 | 0.30989223 |
| 125 | CHEK1 | 0.29913132 |
| 126 | CDC42BPA | 0.29536460 |
| 127 | PAK3 | 0.29246269 |
| 128 | STK38 | 0.28838238 |
| 129 | UHMK1 | 0.28241061 |
| 130 | FER | 0.27721360 |
| 131 | PRKACG | 0.27500814 |
| 132 | PRKD1 | 0.27235963 |
| 133 | EEF2K | 0.26234570 |
| 134 | CAMK4 | 0.26106886 |
| 135 | VRK1 | 0.26061146 |
| 136 | MAP2K1 | 0.26017655 |
| 137 | MAP3K7 | 0.25653763 |
| 138 | CAMK2G | 0.25301592 |
| 139 | PRKACB | 0.25072026 |
| 140 | PRKCI | 0.23722403 |
| 141 | RPS6KA4 | 0.23223350 |
| 142 | PAK1 | 0.22002439 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 6.06066106 |
| 2 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 4.76796601 |
| 3 | Propanoate metabolism_Homo sapiens_hsa00640 | 3.27378143 |
| 4 | Carbon metabolism_Homo sapiens_hsa01200 | 3.12675836 |
| 5 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.02602426 |
| 6 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.95187563 |
| 7 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.89328584 |
| 8 | Pyruvate metabolism_Homo sapiens_hsa00620 | 2.65642345 |
| 9 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.64823018 |
| 10 | Parkinsons disease_Homo sapiens_hsa05012 | 2.51597447 |
| 11 | * Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.42093833 |
| 12 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 2.28960787 |
| 13 | Fatty acid metabolism_Homo sapiens_hsa01212 | 2.16727523 |
| 14 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 2.03734257 |
| 15 | * Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.99573367 |
| 16 | Proteasome_Homo sapiens_hsa03050 | 1.99423766 |
| 17 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.65532435 |
| 18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.61605162 |
| 19 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.48961363 |
| 20 | * Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.48784416 |
| 21 | Alzheimers disease_Homo sapiens_hsa05010 | 1.48481001 |
| 22 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.46721849 |
| 23 | DNA replication_Homo sapiens_hsa03030 | 1.43400245 |
| 24 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.40056128 |
| 25 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.35765082 |
| 26 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.32473787 |
| 27 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.29646966 |
| 28 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.29531454 |
| 29 | Galactose metabolism_Homo sapiens_hsa00052 | 1.26660672 |
| 30 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.25730173 |
| 31 | Peroxisome_Homo sapiens_hsa04146 | 1.23672546 |
| 32 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.23054667 |
| 33 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.21091326 |
| 34 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.14612039 |
| 35 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.13712491 |
| 36 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.13290265 |
| 37 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.11467464 |
| 38 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.10290980 |
| 39 | Mismatch repair_Homo sapiens_hsa03430 | 1.05335919 |
| 40 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.05038783 |
| 41 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.04303884 |
| 42 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.02648236 |
| 43 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.96209380 |
| 44 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.92680395 |
| 45 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.91862856 |
| 46 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.89363890 |
| 47 | Sulfur relay system_Homo sapiens_hsa04122 | 0.86624461 |
| 48 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.86320436 |
| 49 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.85731340 |
| 50 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.84332034 |
| 51 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.84270267 |
| 52 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.83530618 |
| 53 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.83336556 |
| 54 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.81491950 |
| 55 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.80104007 |
| 56 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.79614117 |
| 57 | Protein export_Homo sapiens_hsa03060 | 0.78528939 |
| 58 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.77359063 |
| 59 | Base excision repair_Homo sapiens_hsa03410 | 0.75002551 |
| 60 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.73323569 |
| 61 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.72522996 |
| 62 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.67725349 |
| 63 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.67051831 |
| 64 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.66415378 |
| 65 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.64495913 |
| 66 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.61980309 |
| 67 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.61873956 |
| 68 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.60693032 |
| 69 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.59897206 |
| 70 | RNA polymerase_Homo sapiens_hsa03020 | 0.58843844 |
| 71 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.57542835 |
| 72 | Ribosome_Homo sapiens_hsa03010 | 0.56286750 |
| 73 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.55846516 |
| 74 | RNA transport_Homo sapiens_hsa03013 | 0.54709142 |
| 75 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.52701779 |
| 76 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.51739150 |
| 77 | Purine metabolism_Homo sapiens_hsa00230 | 0.49677869 |
| 78 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.49094714 |
| 79 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.44828775 |
| 80 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.44672107 |
| 81 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.44329042 |
| 82 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.43398011 |
| 83 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.43170574 |
| 84 | Insulin resistance_Homo sapiens_hsa04931 | 0.41744456 |
| 85 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.41347512 |
| 86 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.41195197 |
| 87 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.40409793 |
| 88 | Lysine degradation_Homo sapiens_hsa00310 | 0.39388228 |
| 89 | Spliceosome_Homo sapiens_hsa03040 | 0.38310697 |
| 90 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.37531284 |
| 91 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.37081205 |
| 92 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.36925348 |
| 93 | Other glycan degradation_Homo sapiens_hsa00511 | 0.35376733 |
| 94 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.34717874 |
| 95 | Bile secretion_Homo sapiens_hsa04976 | 0.32931406 |
| 96 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.31952033 |
| 97 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.30373278 |
| 98 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.30167063 |
| 99 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.28202385 |
| 100 | Viral myocarditis_Homo sapiens_hsa05416 | 0.26453817 |
| 101 | Homologous recombination_Homo sapiens_hsa03440 | 0.25531686 |
| 102 | Histidine metabolism_Homo sapiens_hsa00340 | 0.25230134 |
| 103 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.24908594 |
| 104 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.24570611 |
| 105 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.22519752 |
| 106 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.20897510 |
| 107 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.20015573 |
| 108 | Cell cycle_Homo sapiens_hsa04110 | 0.17748618 |
| 109 | RNA degradation_Homo sapiens_hsa03018 | 0.17035828 |
| 110 | Mineral absorption_Homo sapiens_hsa04978 | 0.16568832 |
| 111 | Legionellosis_Homo sapiens_hsa05134 | 0.15087345 |
| 112 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.11503918 |
| 113 | Tight junction_Homo sapiens_hsa04530 | 0.11334787 |
| 114 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.10830586 |
| 115 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.08918685 |
| 116 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.05945922 |
| 117 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.04377687 |

