UQCRC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)7.64246292
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.25091981
3NADH metabolic process (GO:0006734)6.17652904
4ATP synthesis coupled proton transport (GO:0015986)5.74306301
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.74306301
6lysine metabolic process (GO:0006553)5.72305897
7lysine catabolic process (GO:0006554)5.72305897
8regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.71140610
9succinate metabolic process (GO:0006105)5.53865530
10regulation of acyl-CoA biosynthetic process (GO:0050812)5.48763902
11* respiratory electron transport chain (GO:0022904)5.33011864
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.31551963
13creatine metabolic process (GO:0006600)5.28577986
14* electron transport chain (GO:0022900)5.18803224
15regulation of cofactor metabolic process (GO:0051193)5.12602854
16regulation of coenzyme metabolic process (GO:0051196)5.12602854
17sarcoplasmic reticulum calcium ion transport (GO:0070296)5.08351241
18aspartate family amino acid catabolic process (GO:0009068)4.99298099
19oxaloacetate metabolic process (GO:0006107)4.87377013
202-oxoglutarate metabolic process (GO:0006103)4.87216000
21carnitine shuttle (GO:0006853)4.71134124
22cellular ketone body metabolic process (GO:0046950)4.69255028
23fatty acid beta-oxidation (GO:0006635)4.63994434
24* oxidative phosphorylation (GO:0006119)4.53875335
25fatty acid transmembrane transport (GO:1902001)4.47871830
26striated muscle contraction (GO:0006941)4.42654328
27branched-chain amino acid catabolic process (GO:0009083)4.42238326
28skeletal muscle contraction (GO:0003009)4.41138940
29acetyl-CoA metabolic process (GO:0006084)4.30012193
30sarcomere organization (GO:0045214)4.19051713
31regulation of sulfur metabolic process (GO:0042762)4.18160104
32tricarboxylic acid metabolic process (GO:0072350)4.16385473
33fatty acid catabolic process (GO:0009062)4.13300590
34short-chain fatty acid metabolic process (GO:0046459)4.11975841
35fatty acid oxidation (GO:0019395)4.09263007
36ketone body metabolic process (GO:1902224)4.07346575
37glyoxylate metabolic process (GO:0046487)4.03765584
38negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.02817091
39lipid oxidation (GO:0034440)4.01215313
40branched-chain amino acid metabolic process (GO:0009081)4.01025098
41formation of translation preinitiation complex (GO:0001731)4.00468983
42fructose metabolic process (GO:0006000)3.93267137
43positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.91035055
44cardiac myofibril assembly (GO:0055003)3.89129971
45monosaccharide biosynthetic process (GO:0046364)3.82868554
46glycolytic process (GO:0006096)3.82440791
47ATP biosynthetic process (GO:0006754)3.81056800
48response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.80994343
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.80968191
50L-phenylalanine metabolic process (GO:0006558)3.80968191
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.75965954
52L-phenylalanine catabolic process (GO:0006559)3.75965954
53regulation of sequestering of triglyceride (GO:0010889)3.69722937
54monocarboxylic acid catabolic process (GO:0072329)3.69649920
55valine metabolic process (GO:0006573)3.67376105
56carnitine transport (GO:0015879)3.66260792
57amino-acid betaine transport (GO:0015838)3.66260792
58actin filament-based movement (GO:0030048)3.64542357
59carnitine transmembrane transport (GO:1902603)3.63400793
60regulation of fatty acid oxidation (GO:0046320)3.61270386
61regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.60380874
62muscle filament sliding (GO:0030049)3.59717209
63actin-myosin filament sliding (GO:0033275)3.59717209
64cardiac muscle contraction (GO:0060048)3.53392192
65IMP metabolic process (GO:0046040)3.53274500
66negative regulation of potassium ion transmembrane transport (GO:1901380)3.50312957
67proline biosynthetic process (GO:0006561)3.49884990
68regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.49161671
69amino-acid betaine metabolic process (GO:0006577)3.45601894
70Golgi transport vesicle coating (GO:0048200)3.44089522
71COPI coating of Golgi vesicle (GO:0048205)3.44089522
72carnitine metabolic process (GO:0009437)3.41412810
73myofibril assembly (GO:0030239)3.38104419
74fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.37359660
75mitochondrial fusion (GO:0008053)3.33167808
76inner mitochondrial membrane organization (GO:0007007)3.32159561
77gluconeogenesis (GO:0006094)3.29985294
78regulation of translational fidelity (GO:0006450)3.29621529
79biotin metabolic process (GO:0006768)3.24641333
80response to muscle activity (GO:0014850)3.23928000
81ribosomal large subunit biogenesis (GO:0042273)3.23151870
82pyruvate metabolic process (GO:0006090)3.20422849
83alpha-linolenic acid metabolic process (GO:0036109)3.16982040
84regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.16965734
85ventricular cardiac muscle cell action potential (GO:0086005)3.15211336
86quinone biosynthetic process (GO:1901663)3.14984006
87ubiquinone biosynthetic process (GO:0006744)3.14984006
88cysteine metabolic process (GO:0006534)3.14634941
89acyl-CoA metabolic process (GO:0006637)3.14212670
90thioester metabolic process (GO:0035383)3.14212670
91regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.13982559
92kynurenine metabolic process (GO:0070189)3.13660375
93viral transcription (GO:0019083)3.12295792
94aromatic amino acid family catabolic process (GO:0009074)3.11943182
95thioester biosynthetic process (GO:0035384)3.11296299
96acyl-CoA biosynthetic process (GO:0071616)3.11296299
97quaternary ammonium group transport (GO:0015697)3.11226673
98hexose biosynthetic process (GO:0019319)3.09430322
99IMP biosynthetic process (GO:0006188)3.08931912
100NAD metabolic process (GO:0019674)3.08283512
101purine nucleoside triphosphate biosynthetic process (GO:0009145)3.08177025
102regulation of relaxation of muscle (GO:1901077)3.07363609
103carboxylic acid catabolic process (GO:0046395)3.07099175
104organic acid catabolic process (GO:0016054)3.07099175
105positive regulation of fatty acid oxidation (GO:0046321)3.06187680
106actomyosin structure organization (GO:0031032)3.05899677
107purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.04214523
108bundle of His cell to Purkinje myocyte communication (GO:0086069)3.03157406
109glucan biosynthetic process (GO:0009250)3.01766396
110glycogen biosynthetic process (GO:0005978)3.01766396
111translational termination (GO:0006415)3.01389179
112alpha-amino acid catabolic process (GO:1901606)3.00932323
113nucleoside diphosphate biosynthetic process (GO:0009133)3.00907743
114fatty acid homeostasis (GO:0055089)3.00778051
115heart contraction (GO:0060047)3.00776375
116heart process (GO:0003015)3.00776375
117regulation of actin filament-based movement (GO:1903115)2.97985165
118regulation of triglyceride catabolic process (GO:0010896)2.97447787
119dicarboxylic acid catabolic process (GO:0043649)2.97335286
120dicarboxylic acid metabolic process (GO:0043648)2.96007227
121cellular amino acid catabolic process (GO:0009063)2.94631304
122regulation of skeletal muscle contraction (GO:0014819)2.93677438
123regulation of cell communication by electrical coupling (GO:0010649)2.93619929
124glycogen catabolic process (GO:0005980)2.92735379
125actin-mediated cell contraction (GO:0070252)2.91842431
126cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.91804233
127cardiac muscle hypertrophy (GO:0003300)2.91511326
128* aerobic respiration (GO:0009060)2.91095948
129very-low-density lipoprotein particle assembly (GO:0034379)2.87775494
130dicarboxylic acid biosynthetic process (GO:0043650)2.86699727
131purine nucleoside monophosphate biosynthetic process (GO:0009127)2.84648152
132purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.84648152
133striated muscle hypertrophy (GO:0014897)2.84136449
134cardiac muscle tissue morphogenesis (GO:0055008)2.82662478
1354-hydroxyproline metabolic process (GO:0019471)2.79172706
136regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.77938201
137glucan catabolic process (GO:0009251)2.77775657
138nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.76726636
139ribosomal small subunit assembly (GO:0000028)2.74555259
140* cellular respiration (GO:0045333)2.74345375
141translational elongation (GO:0006414)2.74197778
142cell communication involved in cardiac conduction (GO:0086065)2.72935409
143tRNA aminoacylation for protein translation (GO:0006418)2.70950870
144proline metabolic process (GO:0006560)2.70872955
145translational initiation (GO:0006413)2.70606635
146AMP metabolic process (GO:0046033)2.68029242
147SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.67385037
148cellular polysaccharide catabolic process (GO:0044247)2.65831995
149muscle contraction (GO:0006936)2.65530453
150muscle tissue morphogenesis (GO:0060415)2.64777421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.57123656
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.44288503
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.04182969
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.70063315
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.44507971
6PPARA_22158963_ChIP-Seq_LIVER_Mouse4.26756034
7MYC_18555785_ChIP-Seq_MESCs_Mouse4.21754058
8E2F7_22180533_ChIP-Seq_HELA_Human3.85482709
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.63067837
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.25250438
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81631587
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79215535
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.71350569
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.70050945
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.55794068
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.53262216
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51454489
18XRN2_22483619_ChIP-Seq_HELA_Human2.47528288
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.42098915
20AR_21909140_ChIP-Seq_LNCAP_Human2.34956390
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31412021
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24484950
23ZNF263_19887448_ChIP-Seq_K562_Human2.19580541
24EP300_21415370_ChIP-Seq_HL-1_Mouse2.19245504
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.09020253
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07489266
27* CLOCK_20551151_ChIP-Seq_293T_Human2.06389975
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.00880199
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94829684
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88841702
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84761721
32* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82630919
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78767612
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71567024
35* TTF2_22483619_ChIP-Seq_HELA_Human1.69924346
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68847709
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.68779013
38* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65445076
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63827875
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61878580
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58830265
42TBX20_22080862_ChIP-Seq_HEART_Mouse1.58526689
43TBX20_22328084_ChIP-Seq_HEART_Mouse1.58526689
44NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.54280540
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.49840257
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49460583
47TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.48213624
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.46414039
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44556497
50GATA1_22025678_ChIP-Seq_K562_Human1.44101457
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.43389848
52GABP_19822575_ChIP-Seq_HepG2_Human1.39636365
53MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.38046162
54PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.36447966
55* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31304490
56* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.28013156
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.26657636
58CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.26288792
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25586011
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24868812
61JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24352020
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24258779
63HTT_18923047_ChIP-ChIP_STHdh_Human1.23319634
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23185856
65VDR_22108803_ChIP-Seq_LS180_Human1.21114928
66* FOXP3_21729870_ChIP-Seq_TREG_Human1.20997073
67* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20864377
68CIITA_25753668_ChIP-Seq_RAJI_Human1.20676449
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19627036
70SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17803395
71CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14240644
72TAF15_26573619_Chip-Seq_HEK293_Human1.13865054
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13319914
74OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12657406
75NANOG_21062744_ChIP-ChIP_HESCs_Human1.12625323
76* VDR_23849224_ChIP-Seq_CD4+_Human1.12522866
77TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.12075163
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.09331105
79SOX17_20123909_ChIP-Seq_XEN_Mouse1.08879174
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04923642
81ELK1_19687146_ChIP-ChIP_HELA_Human1.04458102
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04243354
83GABP_17652178_ChIP-ChIP_JURKAT_Human1.02227466
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.01563845
85ZNF274_21170338_ChIP-Seq_K562_Hela1.01001380
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00498991
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00186481
88* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00106213
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98639823
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98333327
91HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97289607
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96920203
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96824124
94* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95528229
95ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94925525
96PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93598139
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92873092
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91964152
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89763915
100NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88203532
101* ETS1_20019798_ChIP-Seq_JURKAT_Human0.88108718
102TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.87212415
103BCAT_22108803_ChIP-Seq_LS180_Human0.86922808
104THAP11_20581084_ChIP-Seq_MESCs_Mouse0.86581547
105EZH2_22144423_ChIP-Seq_EOC_Human0.86514405
106MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.86104290
107GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.84801764
108* HNF4A_19822575_ChIP-Seq_HepG2_Human0.84419498
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83904141
110HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.82880528
111* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.81850305
112FOXA2_19822575_ChIP-Seq_HepG2_Human0.80201030
113PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79091415
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.77940160
115CBP_20019798_ChIP-Seq_JUKART_Human0.77940160
116FOXH1_21741376_ChIP-Seq_ESCs_Human0.77031989
117STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75474931
118ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.73245530
119ERG_20517297_ChIP-Seq_VCAP_Human0.72940996
120REST_18959480_ChIP-ChIP_MESCs_Mouse0.72825447
121EGR1_19032775_ChIP-ChIP_M12_Human0.72073194
122* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.71322487
123* EST1_17652178_ChIP-ChIP_JURKAT_Human0.70778333
124EOMES_21245162_ChIP-Seq_HESCs_Human0.69135158
125YY1_21170310_ChIP-Seq_MESCs_Mouse0.68979058
126CBP_21632823_ChIP-Seq_H3396_Human0.68810887
127TBX5_21415370_ChIP-Seq_HL-1_Mouse0.68477483
128NCOR_22424771_ChIP-Seq_293T_Human0.68132993
129* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.67176031
130NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67092719
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67092719
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66569695
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.66440128
134AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66345453
135THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.66282779
136TAF2_19829295_ChIP-Seq_ESCs_Human0.65904534
137DCP1A_22483619_ChIP-Seq_HELA_Human0.64591478
138REST_19997604_ChIP-ChIP_NEURONS_Mouse0.64298586
139* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.63386402
140SOX2_27498859_Chip-Seq_STOMACH_Mouse0.62053556
141GBX2_23144817_ChIP-Seq_PC3_Human0.61883961
142* AR_20517297_ChIP-Seq_VCAP_Human0.61387876
143CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.60995034
144RARB_27405468_Chip-Seq_BRAIN_Mouse0.60715780
145SOX2_21211035_ChIP-Seq_LN229_Gbm0.60018527
146SOX2_19829295_ChIP-Seq_ESCs_Human0.59822372
147NANOG_19829295_ChIP-Seq_ESCs_Human0.59822372
148SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.59079524
149CTBP1_25329375_ChIP-Seq_LNCAP_Human0.58731036
150OCT4_20526341_ChIP-Seq_ESCs_Human0.58278685
151PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57657474
152ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.57602988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.19219480
2MP0003646_muscle_fatigue4.22593108
3MP0005360_urolithiasis4.06853562
4MP0004084_abnormal_cardiac_muscle3.72600433
5MP0002139_abnormal_hepatobiliary_system3.69835529
6MP0004215_abnormal_myocardial_fiber3.51563925
7MP0000751_myopathy3.38566573
8MP0004036_abnormal_muscle_relaxation3.17963274
9MP0003806_abnormal_nucleotide_metabolis3.16382622
10MP0005085_abnormal_gallbladder_physiolo3.11952456
11MP0006036_abnormal_mitochondrial_physio3.09146297
12MP0005330_cardiomyopathy2.86869687
13MP0004130_abnormal_muscle_cell2.78776513
14MP0005365_abnormal_bile_salt2.77131013
15MP0000749_muscle_degeneration2.67563643
16MP0008875_abnormal_xenobiotic_pharmacok2.56751443
17MP0005332_abnormal_amino_acid2.31511211
18MP0004043_abnormal_pH_regulation2.30788074
19MP0003195_calcinosis2.29330094
20MP0002972_abnormal_cardiac_muscle2.20558385
21MP0006035_abnormal_mitochondrial_morpho2.10976198
22MP0008775_abnormal_heart_ventricle2.10007531
23MP0005620_abnormal_muscle_contractility2.06242419
24MP0001661_extended_life_span2.04170521
25MP0004087_abnormal_muscle_fiber2.02656131
26MP0004484_altered_response_of1.91601674
27MP0003221_abnormal_cardiomyocyte_apopto1.88403203
28MP0003137_abnormal_impulse_conducting1.87741951
29MP0010329_abnormal_lipoprotein_level1.86210418
30MP0001544_abnormal_cardiovascular_syste1.77593140
31MP0005385_cardiovascular_system_phenoty1.77593140
32MP0002269_muscular_atrophy1.76161297
33MP0010234_abnormal_vibrissa_follicle1.73092713
34MP0004145_abnormal_muscle_electrophysio1.72463984
35MP0006138_congestive_heart_failure1.67939391
36MP0000747_muscle_weakness1.66592068
37MP0004957_abnormal_blastocyst_morpholog1.65938901
38MP0002106_abnormal_muscle_physiology1.63454573
39MP0003693_abnormal_embryo_hatching1.58668848
40MP0005666_abnormal_adipose_tissue1.54948372
41MP0005670_abnormal_white_adipose1.54523215
42MP0004085_abnormal_heartbeat1.50900944
43MP0003252_abnormal_bile_duct1.47157794
44MP0005584_abnormal_enzyme/coenzyme_acti1.45858056
45MP0004233_abnormal_muscle_weight1.44602996
46MP0010630_abnormal_cardiac_muscle1.42663839
47MP0004270_analgesia1.42249571
48MP0000750_abnormal_muscle_regeneration1.42235797
49MP0002118_abnormal_lipid_homeostasis1.40383035
50MP0001666_abnormal_nutrient_absorption1.37955592
51MP0005319_abnormal_enzyme/_coenzyme1.34622065
52MP0002332_abnormal_exercise_endurance1.34331993
53MP0004147_increased_porphyrin_level1.33812281
54MP0005369_muscle_phenotype1.29562525
55MP0005535_abnormal_body_temperature1.25468379
56MP0000013_abnormal_adipose_tissue1.25021202
57MP0002971_abnormal_brown_adipose1.23583889
58MP0000759_abnormal_skeletal_muscle1.21942041
59MP0001730_embryonic_growth_arrest1.21396947
60MP0005266_abnormal_metabolism1.21190340
61MP0002822_catalepsy1.18861321
62MP0008932_abnormal_embryonic_tissue1.18634759
63MP0009643_abnormal_urine_homeostasis1.15502360
64MP0003111_abnormal_nucleus_morphology1.13479673
65MP0005451_abnormal_body_composition1.10555872
66MP0000230_abnormal_systemic_arterial1.09033484
67MP0005083_abnormal_biliary_tract1.07429934
68MP0002078_abnormal_glucose_homeostasis1.07124664
69MP0003315_abnormal_perineum_morphology1.06254286
70MP0001764_abnormal_homeostasis1.05999333
71MP0004264_abnormal_extraembryonic_tissu1.04978737
72MP0005636_abnormal_mineral_homeostasis1.01574130
73MP0009840_abnormal_foam_cell1.01255251
74MP0003186_abnormal_redox_activity1.00401821
75MP0003329_amyloid_beta_deposits0.98978550
76MP0004185_abnormal_adipocyte_glucose0.97400452
77MP0000609_abnormal_liver_physiology0.96812502
78MP0003941_abnormal_skin_development0.95880923
79MP0005375_adipose_tissue_phenotype0.95191523
80MP0001727_abnormal_embryo_implantation0.94217973
81MP0002127_abnormal_cardiovascular_syste0.92216394
82MP0004019_abnormal_vitamin_homeostasis0.91989109
83MP0010094_abnormal_chromosome_stability0.91434524
84MP0002909_abnormal_adrenal_gland0.87369132
85MP0001756_abnormal_urination0.84675962
86MP0003984_embryonic_growth_retardation0.84185726
87MP0002876_abnormal_thyroid_physiology0.83436147
88MP0003077_abnormal_cell_cycle0.83038688
89MP0003191_abnormal_cellular_cholesterol0.82742220
90MP0002108_abnormal_muscle_morphology0.81157328
91MP0001765_abnormal_ion_homeostasis0.80512361
92MP0000733_abnormal_muscle_development0.80433532
93MP0001529_abnormal_vocalization0.79003559
94MP0002088_abnormal_embryonic_growth/wei0.78802355
95MP0005165_increased_susceptibility_to0.78674430
96MP0009697_abnormal_copulation0.77737277
97MP0009672_abnormal_birth_weight0.76287409
98MP0003656_abnormal_erythrocyte_physiolo0.74074704
99MP0005380_embryogenesis_phenotype0.72302153
100MP0001672_abnormal_embryogenesis/_devel0.72302153
101MP0005376_homeostasis/metabolism_phenot0.71800565
102MP0003828_pulmonary_edema0.71021252
103MP0008058_abnormal_DNA_repair0.70694157
104MP0003868_abnormal_feces_composition0.69926382
105MP0003567_abnormal_fetal_cardiomyocyte0.69815300
106MP0009780_abnormal_chondrocyte_physiolo0.69284668
107MP0002009_preneoplasia0.68971639
108MP0003950_abnormal_plasma_membrane0.68294719
109MP0002080_prenatal_lethality0.66749277
110MP0004924_abnormal_behavior0.66241146
111MP0005386_behavior/neurological_phenoty0.66241146
112MP0000003_abnormal_adipose_tissue0.65593344
113MP0005448_abnormal_energy_balance0.65287375
114MP0001346_abnormal_lacrimal_gland0.64020578
115MP0009379_abnormal_foot_pigmentation0.63640681
116MP0000566_synostosis0.63207292
117MP0001697_abnormal_embryo_size0.60989938
118MP0005334_abnormal_fat_pad0.59452240
119MP0005187_abnormal_penis_morphology0.57662015
120MP0001984_abnormal_olfaction0.57567656
121MP0005058_abnormal_lysosome_morphology0.57306808
122MP0005452_abnormal_adipose_tissue0.55475816
123MP0000604_amyloidosis0.54884736
124MP0003953_abnormal_hormone_level0.53469439
125MP0009642_abnormal_blood_homeostasis0.52042489
126MP0008872_abnormal_physiological_respon0.50702791
127MP0003880_abnormal_central_pattern0.50102423
128MP0000266_abnormal_heart_morphology0.49865543
129MP0000358_abnormal_cell_content/0.47777458
130MP0009745_abnormal_behavioral_response0.47550891
131MP0003959_abnormal_lean_body0.47266465

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.52628124
2Nemaline bodies (HP:0003798)6.44380465
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.31823058
4Abnormal mitochondria in muscle tissue (HP:0008316)4.84166786
5Acute necrotizing encephalopathy (HP:0006965)4.76544394
6Acute encephalopathy (HP:0006846)4.64670722
7Myoglobinuria (HP:0002913)4.59305223
8Hepatic necrosis (HP:0002605)4.50606250
9Type 1 muscle fiber predominance (HP:0003803)4.44788147
10Sudden death (HP:0001699)4.30147282
11Exercise-induced myalgia (HP:0003738)4.28133529
12Cerebral edema (HP:0002181)4.27433836
13Exercise-induced muscle cramps (HP:0003710)4.14771197
14Abnormality of fatty-acid metabolism (HP:0004359)4.08000004
15Progressive macrocephaly (HP:0004481)4.03514344
16Hypoglycemic coma (HP:0001325)4.02838911
17Ketoacidosis (HP:0001993)3.98663842
18Hepatocellular necrosis (HP:0001404)3.97371619
19Mitochondrial inheritance (HP:0001427)3.91671786
20Myopathic facies (HP:0002058)3.88484207
21Increased CSF lactate (HP:0002490)3.86249385
22Rhabdomyolysis (HP:0003201)3.77445535
23Centrally nucleated skeletal muscle fibers (HP:0003687)3.76036886
24Rimmed vacuoles (HP:0003805)3.72750129
25Dicarboxylic aciduria (HP:0003215)3.72344901
26Abnormality of dicarboxylic acid metabolism (HP:0010995)3.72344901
27Palpitations (HP:0001962)3.67691242
28Ketosis (HP:0001946)3.64950296
29Hyperglycinuria (HP:0003108)3.62057727
30Calf muscle hypertrophy (HP:0008981)3.57984822
31Lactic acidosis (HP:0003128)3.45262443
32Distal arthrogryposis (HP:0005684)3.43076704
33Muscle hypertrophy of the lower extremities (HP:0008968)3.41645494
34Abnormality of glycine metabolism (HP:0010895)3.36796523
35Abnormality of serine family amino acid metabolism (HP:0010894)3.36796523
36Increased muscle lipid content (HP:0009058)3.33397045
37* Hyperammonemia (HP:0001987)3.33072749
38Ventricular tachycardia (HP:0004756)3.26592881
39Pheochromocytoma (HP:0002666)3.26394422
40Generalized aminoaciduria (HP:0002909)3.17940608
41Conjunctival hamartoma (HP:0100780)3.15331310
42Ragged-red muscle fibers (HP:0003200)3.12730184
43Lethargy (HP:0001254)3.11398099
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.11080898
45Abnormality of alanine metabolism (HP:0010916)3.11080898
46Hyperalaninemia (HP:0003348)3.11080898
47Neck muscle weakness (HP:0000467)3.06557216
48Neuroendocrine neoplasm (HP:0100634)3.05702799
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.04311710
50* Abnormality of glycolysis (HP:0004366)3.01936983
51* Increased serum pyruvate (HP:0003542)3.01936983
52Increased intramyocellular lipid droplets (HP:0012240)2.98329039
53Respiratory failure (HP:0002878)2.98080819
54Hyperglycinemia (HP:0002154)2.93930814
55Exercise intolerance (HP:0003546)2.88224702
56Right ventricular cardiomyopathy (HP:0011663)2.83534840
57Distal lower limb muscle weakness (HP:0009053)2.81800321
58Progressive muscle weakness (HP:0003323)2.81691483
59Syncope (HP:0001279)2.81106163
60Atrial fibrillation (HP:0005110)2.79375325
61Lipoatrophy (HP:0100578)2.74146192
62Abnormality of the calf musculature (HP:0001430)2.73912230
63Gout (HP:0001997)2.73298152
64* Metabolic acidosis (HP:0001942)2.68434918
65Proximal tubulopathy (HP:0000114)2.68176045
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.65022343
67Decreased activity of mitochondrial respiratory chain (HP:0008972)2.65022343
68Lipid accumulation in hepatocytes (HP:0006561)2.64858354
69Muscle fiber splitting (HP:0003555)2.64494738
70EMG: neuropathic changes (HP:0003445)2.61865166
71Primary atrial arrhythmia (HP:0001692)2.60528141
72Abnormality of aromatic amino acid family metabolism (HP:0004338)2.58631896
73Vomiting (HP:0002013)2.58462678
74Dilated cardiomyopathy (HP:0001644)2.55327408
75Supraventricular tachycardia (HP:0004755)2.55000376
76* Increased serum lactate (HP:0002151)2.48603009
77Ulnar deviation of the wrist (HP:0003049)2.48238951
78Supraventricular arrhythmia (HP:0005115)2.47849234
79Abnormality of urine glucose concentration (HP:0011016)2.47798652
80Glycosuria (HP:0003076)2.47798652
81Calcaneovalgus deformity (HP:0001848)2.47414682
82Abnormality of serum amino acid levels (HP:0003112)2.47173055
83Increased connective tissue (HP:0009025)2.44924327
84Methylmalonic aciduria (HP:0012120)2.43286823
85Hypobetalipoproteinemia (HP:0003563)2.40863759
86CNS demyelination (HP:0007305)2.39637367
87Microvesicular hepatic steatosis (HP:0001414)2.38286683
88Abnormality of the foot musculature (HP:0001436)2.37228981
89Heart block (HP:0012722)2.37153965
90Neoplasm of the adrenal gland (HP:0100631)2.35912403
91Distal lower limb amyotrophy (HP:0008944)2.35856166
92Hyporeflexia of lower limbs (HP:0002600)2.35163281
93Leukodystrophy (HP:0002415)2.34650452
94Abnormality of skeletal muscle fiber size (HP:0012084)2.34097382
95Intrahepatic cholestasis (HP:0001406)2.32434811
96Ventricular arrhythmia (HP:0004308)2.31472075
97EMG: myopathic abnormalities (HP:0003458)2.30141579
98Muscle stiffness (HP:0003552)2.29401167
99Xanthomatosis (HP:0000991)2.29171774
100Nausea (HP:0002018)2.26295121
101Esophageal neoplasm (HP:0100751)2.22649344
102Neoplasm of head and neck (HP:0012288)2.22649344
103Reticulocytosis (HP:0001923)2.20242619
104Hypolipoproteinemia (HP:0010981)2.20179859
105Abnormal atrioventricular conduction (HP:0005150)2.19503061
106Cholelithiasis (HP:0001081)2.19264462
107Prolonged QT interval (HP:0001657)2.19066840
108Progressive external ophthalmoplegia (HP:0000590)2.18491554
109Round ear (HP:0100830)2.16754205
110Increased purine levels (HP:0004368)2.16691420
111Hyperuricemia (HP:0002149)2.16691420
112Increased hepatocellular lipid droplets (HP:0006565)2.14953330
113Optic disc pallor (HP:0000543)2.14451808
114Hypoalphalipoproteinemia (HP:0003233)2.12743526
115Ventricular fibrillation (HP:0001663)2.12198491
116Bundle branch block (HP:0011710)2.11773558
117Multiple enchondromatosis (HP:0005701)2.11027692
118Generalized muscle weakness (HP:0003324)2.10896861
119Deformed tarsal bones (HP:0008119)2.10502576
120Foot dorsiflexor weakness (HP:0009027)2.10086005
121Subaortic stenosis (HP:0001682)2.09368153
122Abnormality of the left ventricular outflow tract (HP:0011103)2.09368153
123Mildly elevated creatine phosphokinase (HP:0008180)2.08750031
124Abnormal gallbladder physiology (HP:0012438)2.07826172
125Cholecystitis (HP:0001082)2.07826172
126Frequent falls (HP:0002359)2.07081174
127Abnormal gallbladder morphology (HP:0012437)2.06618976
128Asymmetric septal hypertrophy (HP:0001670)2.06224067
129Myotonia (HP:0002486)2.05833775
130Areflexia of lower limbs (HP:0002522)2.05374746
131Difficulty running (HP:0009046)2.05227956
132Abnormality of aspartate family amino acid metabolism (HP:0010899)2.03249763
133Malignant hyperthermia (HP:0002047)1.92021913
134Abnormality of reticulocytes (HP:0004312)1.87858629
135Increased variability in muscle fiber diameter (HP:0003557)1.85464730
136Cortical dysplasia (HP:0002539)1.81582364
137Atrioventricular block (HP:0001678)1.78214163
138Absent phalangeal crease (HP:0006109)1.77851212
139Shoulder girdle muscle weakness (HP:0003547)1.77215834

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.04685811
2PDK35.04685811
3BCKDK4.95118101
4OBSCN4.03400704
5NEK13.36484664
6MYLK3.11185527
7PDK23.09881644
8EEF2K3.01589368
9LMTK22.85592844
10TTN2.85322299
11PHKG12.76953909
12PHKG22.76953909
13WNK42.51717207
14SCYL22.49152486
15PKN22.47862736
16SRPK12.31707628
17TRIB32.09399649
18NME12.02259717
19PINK11.83769312
20PBK1.78004705
21MAP2K41.77568150
22EIF2AK31.73949091
23TTK1.71568643
24OXSR11.55023992
25STK241.43838428
26RPS6KB21.42598600
27STK391.40804685
28WNK31.39142215
29TIE11.34825690
30MAP3K41.34544873
31PIK3CA1.28574989
32MAP3K121.28194520
33BUB11.26140721
34STK38L1.14856215
35GRK71.04675101
36STK161.01237424
37PAK31.01075226
38RIPK11.00304127
39MARK10.98175625
40INSRR0.98150925
41ILK0.97746017
42MAP3K60.97257227
43MAP2K70.96370353
44CAMK2D0.95070228
45EIF2AK10.94616657
46PLK40.92610245
47MAPK120.90329388
48RAF10.88053651
49LIMK10.80017313
50MAP3K70.79429788
51LATS20.76677537
52ARAF0.76413939
53ERBB30.76379742
54FLT30.73948300
55VRK20.73384883
56CAMK2G0.72424595
57PRKAA10.72079021
58CAMK2A0.71698764
59CASK0.71226994
60NEK90.70584433
61ICK0.69023202
62MINK10.67549428
63NME20.67213653
64PRKAA20.67171150
65EPHA40.64924649
66DAPK30.64340060
67RPS6KB10.63156222
68DAPK20.62517187
69PRPF4B0.61977057
70ALK0.61177559
71MST1R0.60860328
72DMPK0.60036818
73MAPKAPK50.59971912
74PIK3CG0.59104987
75KSR20.58292209
76TSSK60.58096138
77PDPK10.57838692
78MUSK0.55914608
79MAP3K50.55716814
80CDK190.53873563
81EPHA30.53194447
82SGK4940.51979689
83SGK2230.51979689
84PRKACG0.51499454
85MAPKAPK30.51003753
86PRKD10.50859255
87CDK11A0.50560020
88MAP2K10.50493828
89CSNK1E0.50224932
90PRKACA0.49831806
91CSNK2A20.49472010
92TESK20.48800909
93PTK2B0.48601728
94PDK10.47940524
95NTRK30.47594151
96EIF2AK20.46675523
97CDK150.46620545
98MAP3K130.46410483
99FGFR40.45732345
100RPS6KA40.44295219
101CDK180.44036483
102AURKB0.43822768
103MAP2K60.43403170
104CAMK2B0.42814074
105FGFR30.42657839
106PLK20.42460507
107FER0.41305031
108PRKCG0.41265034
109ROCK10.41179298
110CDK140.39866320
111MAP3K20.39712933
112PRKACB0.39504888
113MAP2K30.39359736
114KDR0.39234119
115NEK20.39203349
116ERBB40.39083045
117MAPK110.38998561
118CDK60.38757314
119DAPK10.36663615
120CCNB10.36128851
121AKT20.35419428
122SMG10.35367895
123MAPK40.35271442
124CAMK40.34304693
125WNK10.34010589
126PRKCE0.33525377
127CHEK10.33317599
128CSNK2A10.32564006
129SIK10.32252662
130ABL20.30961965
131PLK10.30146109
132MAP3K110.30079140
133BCR0.29794378
134STK380.29083330
135ROCK20.28382188
136CAMK10.28195886
137CDC70.27756480
138KSR10.27474667
139SGK20.26408552
140TRPM70.26396472
141DYRK1B0.26278951
142PRKDC0.26134151
143RPS6KA30.25400870
144ADRBK10.22734400
145RET0.21846906
146PRKD30.21785232
147SGK30.20070564
148GRK50.19792963

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.27613981
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.89023786
3Propanoate metabolism_Homo sapiens_hsa006403.60216956
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.15574355
5Fatty acid degradation_Homo sapiens_hsa000713.03293447
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.02622526
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.97117464
8* Oxidative phosphorylation_Homo sapiens_hsa001902.95842298
9Parkinsons disease_Homo sapiens_hsa050122.71996491
10Pyruvate metabolism_Homo sapiens_hsa006202.70407764
11Carbon metabolism_Homo sapiens_hsa012002.62148406
12Butanoate metabolism_Homo sapiens_hsa006502.44630604
13Fatty acid metabolism_Homo sapiens_hsa012122.44183886
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27926515
15* Cardiac muscle contraction_Homo sapiens_hsa042601.96682966
16Alzheimers disease_Homo sapiens_hsa050101.96016460
17Ribosome_Homo sapiens_hsa030101.87602652
18Fatty acid elongation_Homo sapiens_hsa000621.84984875
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.84222099
20Tryptophan metabolism_Homo sapiens_hsa003801.72942499
21* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.72499224
22Arginine biosynthesis_Homo sapiens_hsa002201.70722751
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.67745632
24Huntingtons disease_Homo sapiens_hsa050161.67238222
25Biosynthesis of amino acids_Homo sapiens_hsa012301.65979623
26Peroxisome_Homo sapiens_hsa041461.59445068
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.56930754
28PPAR signaling pathway_Homo sapiens_hsa033201.55593425
29beta-Alanine metabolism_Homo sapiens_hsa004101.47226038
30Nitrogen metabolism_Homo sapiens_hsa009101.45429809
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44753420
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40717926
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36708663
34Sulfur metabolism_Homo sapiens_hsa009201.29396147
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20322898
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.17065155
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13950142
38Phenylalanine metabolism_Homo sapiens_hsa003601.08248832
39Starch and sucrose metabolism_Homo sapiens_hsa005001.08046938
40Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99620162
41Renin-angiotensin system_Homo sapiens_hsa046140.87920695
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86975712
43Arginine and proline metabolism_Homo sapiens_hsa003300.83916420
44One carbon pool by folate_Homo sapiens_hsa006700.83610784
45Dilated cardiomyopathy_Homo sapiens_hsa054140.82597854
46DNA replication_Homo sapiens_hsa030300.82120242
47Fat digestion and absorption_Homo sapiens_hsa049750.82112512
48Tyrosine metabolism_Homo sapiens_hsa003500.81772505
49Steroid biosynthesis_Homo sapiens_hsa001000.81639664
50Bile secretion_Homo sapiens_hsa049760.79546346
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78402330
52Fructose and mannose metabolism_Homo sapiens_hsa000510.78088708
53Spliceosome_Homo sapiens_hsa030400.72799407
54Fatty acid biosynthesis_Homo sapiens_hsa000610.70036405
55Pentose phosphate pathway_Homo sapiens_hsa000300.69579548
56RNA transport_Homo sapiens_hsa030130.68241384
57Glucagon signaling pathway_Homo sapiens_hsa049220.68022226
58Chemical carcinogenesis_Homo sapiens_hsa052040.67403170
59* Metabolic pathways_Homo sapiens_hsa011000.66555655
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66140980
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65807848
62Proteasome_Homo sapiens_hsa030500.63385292
63Mismatch repair_Homo sapiens_hsa034300.62254008
64Collecting duct acid secretion_Homo sapiens_hsa049660.61906054
65Glycerolipid metabolism_Homo sapiens_hsa005610.60899519
66Histidine metabolism_Homo sapiens_hsa003400.60023153
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59992169
68Galactose metabolism_Homo sapiens_hsa000520.58812563
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57530283
70Glutathione metabolism_Homo sapiens_hsa004800.57004099
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.55837083
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.55354798
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53241697
74Selenocompound metabolism_Homo sapiens_hsa004500.53132178
75Caffeine metabolism_Homo sapiens_hsa002320.50799666
76Base excision repair_Homo sapiens_hsa034100.50364583
77Circadian rhythm_Homo sapiens_hsa047100.50178874
78mRNA surveillance pathway_Homo sapiens_hsa030150.47829048
79Folate biosynthesis_Homo sapiens_hsa007900.46728101
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46413726
81Nucleotide excision repair_Homo sapiens_hsa034200.43540915
82Complement and coagulation cascades_Homo sapiens_hsa046100.42275405
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41556474
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.41199292
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41149357
86Purine metabolism_Homo sapiens_hsa002300.41114903
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38904789
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38886709
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.38528262
90Insulin resistance_Homo sapiens_hsa049310.38367498
91Other glycan degradation_Homo sapiens_hsa005110.37739680
92Retinol metabolism_Homo sapiens_hsa008300.37374550
93AMPK signaling pathway_Homo sapiens_hsa041520.33248757
94Mineral absorption_Homo sapiens_hsa049780.31279957
95Vitamin B6 metabolism_Homo sapiens_hsa007500.30833730
96Insulin signaling pathway_Homo sapiens_hsa049100.30632356
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29529364
98Lysine degradation_Homo sapiens_hsa003100.29390655
99Oocyte meiosis_Homo sapiens_hsa041140.28512798
100Sulfur relay system_Homo sapiens_hsa041220.28080222
101RNA degradation_Homo sapiens_hsa030180.23334513
102Vibrio cholerae infection_Homo sapiens_hsa051100.20567345
103ABC transporters_Homo sapiens_hsa020100.19908480
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.19484082
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.18846864
106Pyrimidine metabolism_Homo sapiens_hsa002400.17678051
107Vitamin digestion and absorption_Homo sapiens_hsa049770.16782985
108HIF-1 signaling pathway_Homo sapiens_hsa040660.16589044
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15981571
110Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.15795238
111Calcium signaling pathway_Homo sapiens_hsa040200.15708330
112Non-homologous end-joining_Homo sapiens_hsa034500.15410781
113Renin secretion_Homo sapiens_hsa049240.14704467
114Synaptic vesicle cycle_Homo sapiens_hsa047210.14463651
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12961068
116Gastric acid secretion_Homo sapiens_hsa049710.12955429
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.09866028
118GABAergic synapse_Homo sapiens_hsa047270.09277723
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.06869198
120Insulin secretion_Homo sapiens_hsa049110.06862810
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.02882243
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.02398652
123Oxytocin signaling pathway_Homo sapiens_hsa049210.01868847

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