UQCRFS1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.86639877
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.81713049
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.48202430
4ATP synthesis coupled proton transport (GO:0015986)4.48202430
5iron-sulfur cluster assembly (GO:0016226)4.47215065
6metallo-sulfur cluster assembly (GO:0031163)4.47215065
7regulation of mitochondrial translation (GO:0070129)4.28207944
8proteasome assembly (GO:0043248)4.15647900
9negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.09461977
10establishment of viral latency (GO:0019043)4.08112292
11respiratory electron transport chain (GO:0022904)4.03733208
12DNA deamination (GO:0045006)4.03050807
13oxidative phosphorylation (GO:0006119)3.99688460
14protein complex biogenesis (GO:0070271)3.99140974
15electron transport chain (GO:0022900)3.95328425
16regulation of cellular amino acid metabolic process (GO:0006521)3.87039197
17pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.83444356
18NADH dehydrogenase complex assembly (GO:0010257)3.82500258
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.82500258
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.82500258
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.81564094
22mitochondrial respiratory chain complex assembly (GO:0033108)3.77991921
23negative regulation of ligase activity (GO:0051352)3.73593137
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.73593137
25establishment of integrated proviral latency (GO:0075713)3.73191377
26positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.67162851
27chaperone-mediated protein transport (GO:0072321)3.65448081
28protein deneddylation (GO:0000338)3.64044969
29DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.63935949
30cullin deneddylation (GO:0010388)3.58572938
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.58410538
32signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.55358620
33signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.55358620
34signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.55358620
35purine deoxyribonucleotide catabolic process (GO:0009155)3.55287220
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.54578443
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.54578443
38deoxyribonucleotide catabolic process (GO:0009264)3.52628575
39GTP biosynthetic process (GO:0006183)3.52594480
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.48610739
41deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.48243324
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.44793407
43signal transduction involved in DNA damage checkpoint (GO:0072422)3.44793407
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.41813758
45protein targeting to mitochondrion (GO:0006626)3.40883218
46deoxyribose phosphate catabolic process (GO:0046386)3.40092629
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.38987758
48base-excision repair, AP site formation (GO:0006285)3.38462677
49pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.37945966
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.36224909
51positive regulation of prostaglandin secretion (GO:0032308)3.33177195
52ubiquinone biosynthetic process (GO:0006744)3.33081806
53guanosine-containing compound biosynthetic process (GO:1901070)3.31720546
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.29594727
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.29594727
56negative regulation of B cell apoptotic process (GO:0002903)3.26756525
57establishment of protein localization to mitochondrion (GO:0072655)3.23306725
58purine nucleotide salvage (GO:0032261)3.23301640
59peptidyl-arginine omega-N-methylation (GO:0035247)3.21994776
60respiratory chain complex IV assembly (GO:0008535)3.21547722
61antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.17813411
62pyrimidine nucleotide catabolic process (GO:0006244)3.16188468
63cytochrome complex assembly (GO:0017004)3.14521799
64positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.12978042
65UTP biosynthetic process (GO:0006228)3.11020282
66protein localization to mitochondrion (GO:0070585)3.10268103
67nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.10064858
68pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.08078969
69ubiquinone metabolic process (GO:0006743)3.05908915
702-deoxyribonucleotide metabolic process (GO:0009394)3.04962072
71positive regulation of ligase activity (GO:0051351)3.02926403
72mannosylation (GO:0097502)3.01515764
73UTP metabolic process (GO:0046051)3.01319289
74L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.00761133
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00125958
76spliceosomal snRNP assembly (GO:0000387)2.98334507
77tricarboxylic acid cycle (GO:0006099)2.97504204
78NADH metabolic process (GO:0006734)2.94763222
79deoxyribose phosphate metabolic process (GO:0019692)2.91629684
80pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.91505777
81protein neddylation (GO:0045116)2.90519350
82deoxyribose phosphate biosynthetic process (GO:0046385)2.90283017
832-deoxyribonucleotide biosynthetic process (GO:0009265)2.90283017
84pseudouridine synthesis (GO:0001522)2.88697062
85CTP metabolic process (GO:0046036)2.87437065
86CTP biosynthetic process (GO:0006241)2.87437065
87protein maturation by protein folding (GO:0022417)2.87426147
88purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.87145676
89purine nucleoside triphosphate biosynthetic process (GO:0009145)2.84399167
90purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.83505224
91DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.83235127
92mitochondrial calcium ion transport (GO:0006851)2.82688429
93peptidyl-histidine modification (GO:0018202)2.82019010
94purine deoxyribonucleotide metabolic process (GO:0009151)2.78162659
95transcription elongation from RNA polymerase III promoter (GO:0006385)2.78088389
96termination of RNA polymerase III transcription (GO:0006386)2.78088389
97quinone biosynthetic process (GO:1901663)2.77544997
98aerobic respiration (GO:0009060)2.76402758
99telomere maintenance via semi-conservative replication (GO:0032201)2.75429132
100regulation of ubiquitin-protein transferase activity (GO:0051438)2.74744105

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.23965028
2JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.85259286
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.80125740
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.64354451
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51750273
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.32631626
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.26584520
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.24632325
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.10063906
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.96736430
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.95445958
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85420703
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.80457016
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.78798195
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.70740176
16VDR_23849224_ChIP-Seq_CD4+_Human2.63413013
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.60990135
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59512909
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.50554100
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.49906008
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.45536044
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.43783256
23E2F7_22180533_ChIP-Seq_HELA_Human2.38105155
24GABP_19822575_ChIP-Seq_HepG2_Human2.27618485
25FOXP3_21729870_ChIP-Seq_TREG_Human2.27054216
26DCP1A_22483619_ChIP-Seq_HELA_Human2.26450600
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25278462
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18582111
29XRN2_22483619_ChIP-Seq_HELA_Human2.17247146
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11629539
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.02976021
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00979583
33ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.99417455
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96320207
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.91055961
36CIITA_25753668_ChIP-Seq_RAJI_Human1.84448492
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79444554
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78792989
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78739290
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77161379
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76584753
42TTF2_22483619_ChIP-Seq_HELA_Human1.74363815
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74115580
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73490405
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72727207
46BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.71484397
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.68490226
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.67751920
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65452091
50ELK1_19687146_ChIP-ChIP_HELA_Human1.65182023
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58848020
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46226464
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.43519850
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41109958
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40090281
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37654934
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33088730
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32881822
59KDM5A_27292631_Chip-Seq_BREAST_Human1.29954033
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29303727
61MYC_18940864_ChIP-ChIP_HL60_Human1.27986897
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26278587
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21771326
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20081004
65ZNF263_19887448_ChIP-Seq_K562_Human1.18279852
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16078097
67CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14672281
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13273579
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12927652
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.12325867
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12225106
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11466529
73IRF1_19129219_ChIP-ChIP_H3396_Human1.11439270
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11280710
75BCL6_27268052_Chip-Seq_Bcells_Human1.10756857
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09803889
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.09158797
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.08378113
79SPI1_23547873_ChIP-Seq_NB4_Human1.06634794
80CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06415251
81STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05938803
82ELK1_22589737_ChIP-Seq_MCF10A_Human1.04451741
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03929804
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03068641
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02998971
86FOXP1_21924763_ChIP-Seq_HESCs_Human0.98021037
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97165646
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96524321
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96320692
90PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95786719
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95533548
92YY1_22570637_ChIP-Seq_MALME-3M_Human0.94380076
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93657231
94VDR_21846776_ChIP-Seq_THP-1_Human0.91822016
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91518636
96E2F1_21310950_ChIP-Seq_MCF-7_Human0.90861240
97SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88959604
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87552324
99CTCF_26484167_Chip-Seq_Bcells_Mouse0.86561221
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86298211

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006036_abnormal_mitochondrial_physio3.19200984
2MP0008058_abnormal_DNA_repair3.17430080
3MP0003806_abnormal_nucleotide_metabolis3.14767898
4MP0005645_abnormal_hypothalamus_physiol2.98304697
5MP0005671_abnormal_response_to2.90941854
6MP0010094_abnormal_chromosome_stability2.70202622
7MP0001835_abnormal_antigen_presentation2.57798792
8MP0003693_abnormal_embryo_hatching2.47699990
9MP0001529_abnormal_vocalization2.28686350
10MP0006035_abnormal_mitochondrial_morpho2.19422557
11MP0004145_abnormal_muscle_electrophysio2.17135923
12MP0009785_altered_susceptibility_to2.16108817
13MP0002102_abnormal_ear_morphology2.15559603
14MP0004147_increased_porphyrin_level2.08647996
15MP0002148_abnormal_hypersensitivity_rea2.06232089
16MP0003786_premature_aging2.05484470
17MP0009333_abnormal_splenocyte_physiolog2.01792064
18MP0003111_abnormal_nucleus_morphology1.97523127
19MP0003763_abnormal_thymus_physiology1.89505624
20MP0008007_abnormal_cellular_replicative1.86152555
21MP0003186_abnormal_redox_activity1.82844494
22MP0005075_abnormal_melanosome_morpholog1.78065731
23MP0000685_abnormal_immune_system1.77006320
24MP0004957_abnormal_blastocyst_morpholog1.66799526
25MP0005000_abnormal_immune_tolerance1.65448112
26MP0009764_decreased_sensitivity_to1.63391539
27MP0001800_abnormal_humoral_immune1.63215415
28MP0008932_abnormal_embryonic_tissue1.59984099
29MP0002822_catalepsy1.59955475
30MP0003646_muscle_fatigue1.59429064
31MP0009697_abnormal_copulation1.59159921
32MP0005084_abnormal_gallbladder_morpholo1.53807250
33MP0001727_abnormal_embryo_implantation1.50455569
34MP0003077_abnormal_cell_cycle1.50357207
35MP0001873_stomach_inflammation1.46003294
36MP0005330_cardiomyopathy1.45741880
37MP0002452_abnormal_antigen_presenting1.45518982
38MP0006072_abnormal_retinal_apoptosis1.44774946
39MP0009278_abnormal_bone_marrow1.43716604
40MP0000465_gastrointestinal_hemorrhage1.43167702
41MP0002723_abnormal_immune_serum1.43150511
42MP0001819_abnormal_immune_cell1.42310514
43MP0005025_abnormal_response_to1.41111057
44MP0002420_abnormal_adaptive_immunity1.40521258
45MP0000751_myopathy1.39561731
46MP0002837_dystrophic_cardiac_calcinosis1.38988983
47MP0002653_abnormal_ependyma_morphology1.38910333
48MP0001790_abnormal_immune_system1.36920510
49MP0005387_immune_system_phenotype1.36920510
50MP0003866_abnormal_defecation1.34692604
51MP0000749_muscle_degeneration1.33768291
52MP0003718_maternal_effect1.32049080
53MP0002398_abnormal_bone_marrow1.31465473
54MP0000689_abnormal_spleen_morphology1.30864947
55MP0001764_abnormal_homeostasis1.30473334
56MP0000372_irregular_coat_pigmentation1.24001735
57MP0003221_abnormal_cardiomyocyte_apopto1.22563138
58MP0002019_abnormal_tumor_incidence1.22377838
59MP0002722_abnormal_immune_system1.21620489
60MP0003436_decreased_susceptibility_to1.21308421
61MP0000750_abnormal_muscle_regeneration1.20709433
62MP0008789_abnormal_olfactory_epithelium1.19922093
63MP0000716_abnormal_immune_system1.19838938
64MP0003315_abnormal_perineum_morphology1.18134084
65MP0002163_abnormal_gland_morphology1.17862593
66MP0005266_abnormal_metabolism1.16441647
67MP0005451_abnormal_body_composition1.15071939
68MP0002277_abnormal_respiratory_mucosa1.14313984
69MP0002429_abnormal_blood_cell1.12033208
70MP0001905_abnormal_dopamine_level1.11201470
71MP0008872_abnormal_physiological_respon1.06219031
72MP0001845_abnormal_inflammatory_respons1.04915581
73MP0006276_abnormal_autonomic_nervous1.03645899
74MP0005397_hematopoietic_system_phenotyp1.02682644
75MP0001545_abnormal_hematopoietic_system1.02682644
76MP0000490_abnormal_crypts_of1.01225563
77MP0004510_myositis1.00506124
78MP0000313_abnormal_cell_death1.00146705
79MP0009763_increased_sensitivity_to0.99762512
80MP0008469_abnormal_protein_level0.98307720
81MP0000358_abnormal_cell_content/0.97762058
82MP0005165_increased_susceptibility_to0.92143647
83MP0002106_abnormal_muscle_physiology0.91012577
84MP0002332_abnormal_exercise_endurance0.90809867
85MP0003137_abnormal_impulse_conducting0.89557947
86MP0010155_abnormal_intestine_physiology0.89345074
87MP0008995_early_reproductive_senescence0.89038566
88MP0000747_muscle_weakness0.88717618
89MP0000516_abnormal_urinary_system0.87681892
90MP0005367_renal/urinary_system_phenotyp0.87681892
91MP0000703_abnormal_thymus_morphology0.84846425
92MP0002166_altered_tumor_susceptibility0.83643694
93MP0002006_tumorigenesis0.82940957
94MP0005584_abnormal_enzyme/coenzyme_acti0.82928749
95MP0005670_abnormal_white_adipose0.81258658
96MP0005319_abnormal_enzyme/_coenzyme0.79936847
97MP0002234_abnormal_pharynx_morphology0.79434869
98MP0005332_abnormal_amino_acid0.78440475
99MP0008875_abnormal_xenobiotic_pharmacok0.78417370
100MP0002419_abnormal_innate_immunity0.74977055

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)5.40428322
2Abnormal mitochondria in muscle tissue (HP:0008316)5.23455380
3Mitochondrial inheritance (HP:0001427)5.09027828
4Hepatic necrosis (HP:0002605)4.97702037
5Acute necrotizing encephalopathy (HP:0006965)4.97433259
6Increased intramyocellular lipid droplets (HP:0012240)4.72867279
7Increased CSF lactate (HP:0002490)4.58999688
8Decreased activity of mitochondrial respiratory chain (HP:0008972)4.47993513
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.47993513
10Acute encephalopathy (HP:0006846)4.42021757
11Increased muscle lipid content (HP:0009058)4.36304937
12Progressive macrocephaly (HP:0004481)3.85253999
13Lipid accumulation in hepatocytes (HP:0006561)3.82513440
14Increased hepatocellular lipid droplets (HP:0006565)3.80487742
15Lactic acidosis (HP:0003128)3.64859160
16Increased serum lactate (HP:0002151)3.58845549
17Cerebral edema (HP:0002181)3.48800228
18Exercise intolerance (HP:0003546)3.31011076
19Aplastic anemia (HP:0001915)3.26777894
20Renal Fanconi syndrome (HP:0001994)3.13905281
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.12325036
22Increased serum pyruvate (HP:0003542)3.00524597
23Ragged-red muscle fibers (HP:0003200)2.98739696
24IgM deficiency (HP:0002850)2.97670573
25Respiratory failure (HP:0002878)2.97416879
26Abnormality of glycolysis (HP:0004366)2.96296634
27Dicarboxylic aciduria (HP:0003215)2.89907096
28Abnormality of dicarboxylic acid metabolism (HP:0010995)2.89907096
29Type I transferrin isoform profile (HP:0003642)2.88101923
30Microvesicular hepatic steatosis (HP:0001414)2.85767764
31Abnormality of the anterior horn cell (HP:0006802)2.83510217
32Degeneration of anterior horn cells (HP:0002398)2.83510217
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.75750047
34Rhabdomyolysis (HP:0003201)2.71715622
35Emotional lability (HP:0000712)2.70682272
363-Methylglutaconic aciduria (HP:0003535)2.67056200
37IgG deficiency (HP:0004315)2.59015051
38Exertional dyspnea (HP:0002875)2.56909472
39Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.56639216
40Abnormal protein N-linked glycosylation (HP:0012347)2.56639216
41Abnormal protein glycosylation (HP:0012346)2.56639216
42Abnormal glycosylation (HP:0012345)2.56639216
43B lymphocytopenia (HP:0010976)2.52883197
44Myoglobinuria (HP:0002913)2.50483122
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49013502
46Abnormality of alanine metabolism (HP:0010916)2.49013502
47Hyperalaninemia (HP:0003348)2.49013502
48Methylmalonic aciduria (HP:0012120)2.47556727
49Optic disc pallor (HP:0000543)2.46454264
50Lethargy (HP:0001254)2.35935025
51Abnormality of B cell number (HP:0010975)2.34768990
52CNS demyelination (HP:0007305)2.34204514
53Elevated erythrocyte sedimentation rate (HP:0003565)2.31241006
54Pancytopenia (HP:0001876)2.29671412
55Nemaline bodies (HP:0003798)2.27921232
56Progressive microcephaly (HP:0000253)2.27866665
57Atrophy/Degeneration involving motor neurons (HP:0007373)2.27038113
58Cerebral palsy (HP:0100021)2.23806454
59Leukodystrophy (HP:0002415)2.18646481
60Generalized aminoaciduria (HP:0002909)2.15967356
61Palpitations (HP:0001962)2.12427026
62Muscle fiber atrophy (HP:0100295)2.10901677
63Hyperglycinemia (HP:0002154)2.08944940
64Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.06979686
65Muscle fiber inclusion bodies (HP:0100299)2.06126011
66Methylmalonic acidemia (HP:0002912)2.05052332
67Respiratory difficulties (HP:0002880)2.04882665
68Severe combined immunodeficiency (HP:0004430)2.02760879
69Gliosis (HP:0002171)2.00147757
70Microretrognathia (HP:0000308)1.99474473
71Increased IgM level (HP:0003496)1.99459700
72Opisthotonus (HP:0002179)1.91175351
73Agammaglobulinemia (HP:0004432)1.90891908
74Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89738078
75Reduced antithrombin III activity (HP:0001976)1.89564996
76Oral leukoplakia (HP:0002745)1.88977427
77Type 2 muscle fiber atrophy (HP:0003554)1.87782443
78Abnormality of glycine metabolism (HP:0010895)1.87542430
79Abnormality of serine family amino acid metabolism (HP:0010894)1.87542430
80Hyperglycinuria (HP:0003108)1.83827051
81Rimmed vacuoles (HP:0003805)1.82033988
82Abnormality of serum amino acid levels (HP:0003112)1.80770359
83Aplasia/hypoplasia of the uterus (HP:0008684)1.79203502
84Cleft eyelid (HP:0000625)1.77846747
85Hepatosplenomegaly (HP:0001433)1.76626363
86Progressive muscle weakness (HP:0003323)1.76236862
87Exercise-induced muscle cramps (HP:0003710)1.75207985
88Abnormality of fatty-acid metabolism (HP:0004359)1.75082387
89Cerebral hypomyelination (HP:0006808)1.70618923
90Nausea (HP:0002018)1.68140984
91Retinal dysplasia (HP:0007973)1.67821961
92Mediastinal lymphadenopathy (HP:0100721)1.67248067
93Combined immunodeficiency (HP:0005387)1.66915179
94Ketoacidosis (HP:0001993)1.66581303
95Abnormality of the prostate (HP:0008775)1.66349237
96Delayed CNS myelination (HP:0002188)1.65493742
97Petechiae (HP:0000967)1.64698889
98Hypertensive crisis (HP:0100735)1.64272736
99Testicular atrophy (HP:0000029)1.64206940
100Abnormality of T cell physiology (HP:0011840)1.63927374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.52058361
2BCKDK4.38390926
3TESK23.62702064
4KDR3.33788838
5BUB12.85940356
6NME22.57639320
7ZAK2.53863938
8TESK12.50428030
9VRK12.45673092
10SRPK12.20869012
11SCYL22.16346338
12MAP4K22.12108628
13PIM22.06519536
14LIMK11.99471080
15NEK11.93988308
16MAP3K111.89879934
17MAP2K71.81187943
18CSNK1G31.76821898
19ARAF1.75580485
20TLK11.66282429
21CDC71.63379298
22MAP4K11.58601970
23STK161.47867372
24NUAK11.47733504
25CSNK1A1L1.35862776
26CSNK1G11.35262583
27TXK1.31151947
28CSNK1G21.30207055
29DAPK11.29557370
30RPS6KA51.21467298
31OBSCN1.16217822
32CDK191.16114502
33RPS6KA41.15011271
34TBK11.12687712
35AURKA1.09499918
36TAOK31.05340953
37MAPKAPK31.02978132
38TRIM280.98695824
39DAPK30.98656281
40PLK40.98486745
41CCNB10.97347682
42BCR0.96930414
43NME10.96074396
44KIT0.90677968
45MAP3K120.89452130
46MST40.89247403
47IKBKB0.87900994
48TAOK20.87626096
49ABL20.86402008
50DYRK20.84756598
51CDK80.83927965
52IKBKE0.83055592
53EIF2AK30.81305246
54AURKB0.81072356
55TSSK60.79512844
56ATR0.79095640
57ADRBK20.74809090
58WNK30.71904401
59CHEK20.68453863
60PLK10.65214596
61ERBB30.64401905
62IRAK30.57186529
63SYK0.56921068
64PDK20.55269270
65MAP3K40.55259392
66PHKG20.54845921
67PHKG10.54845921
68GRK70.53651080
69PBK0.52563097
70DYRK30.50283828
71MUSK0.50077313
72MYLK0.50028669
73LMTK20.49223456
74CSNK2A10.48873832
75PRKCI0.48582242
76TAF10.46524082
77CDK70.42435838
78CDK140.41911586
79CSNK2A20.41535592
80MATK0.41362536
81GRK60.40997037
82PAK10.40978194
83ILK0.40869306
84EIF2AK20.40604152
85DYRK1B0.38734639
86PINK10.35933852
87LYN0.35722633
88FLT30.34712136
89PLK30.34337454
90MAPK110.33736642
91BRAF0.33394726
92GRK10.33166848
93CSNK1A10.32298796
94PASK0.32031899
95PIM10.31666223
96MAP3K50.31657229
97CSF1R0.31601158
98CDK11A0.31216287
99MAP3K140.30727736
100IRAK40.28682542

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.39588455
2Oxidative phosphorylation_Homo sapiens_hsa001903.54536789
3Parkinsons disease_Homo sapiens_hsa050123.25843707
4DNA replication_Homo sapiens_hsa030302.69364714
5Ribosome_Homo sapiens_hsa030102.37021635
6Base excision repair_Homo sapiens_hsa034102.32709649
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.30263227
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.21399326
9Primary immunodeficiency_Homo sapiens_hsa053402.18981688
10RNA polymerase_Homo sapiens_hsa030202.16282915
11Mismatch repair_Homo sapiens_hsa034302.16157383
12Huntingtons disease_Homo sapiens_hsa050162.13020287
13Asthma_Homo sapiens_hsa053102.05131691
14Alzheimers disease_Homo sapiens_hsa050101.97381970
15Pyrimidine metabolism_Homo sapiens_hsa002401.81051270
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.78400937
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76147669
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73447864
19Sulfur relay system_Homo sapiens_hsa041221.73172443
20Spliceosome_Homo sapiens_hsa030401.71843119
21Allograft rejection_Homo sapiens_hsa053301.71256986
22Systemic lupus erythematosus_Homo sapiens_hsa053221.69854349
23Fatty acid elongation_Homo sapiens_hsa000621.67516154
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64565457
25Autoimmune thyroid disease_Homo sapiens_hsa053201.56353450
26Homologous recombination_Homo sapiens_hsa034401.53106732
27Protein export_Homo sapiens_hsa030601.51494715
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50126142
29Cardiac muscle contraction_Homo sapiens_hsa042601.48032998
30Graft-versus-host disease_Homo sapiens_hsa053321.43870383
31Type I diabetes mellitus_Homo sapiens_hsa049401.43039780
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40361000
33Carbon metabolism_Homo sapiens_hsa012001.40213662
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39357045
35Biosynthesis of amino acids_Homo sapiens_hsa012301.28550254
36Nucleotide excision repair_Homo sapiens_hsa034201.28271340
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26084323
38Antigen processing and presentation_Homo sapiens_hsa046121.25496206
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23983767
40Viral myocarditis_Homo sapiens_hsa054161.20084199
41Sulfur metabolism_Homo sapiens_hsa009201.19242167
42Non-homologous end-joining_Homo sapiens_hsa034501.16710011
43Purine metabolism_Homo sapiens_hsa002301.14499704
44Pyruvate metabolism_Homo sapiens_hsa006201.11143614
45RNA degradation_Homo sapiens_hsa030181.07187568
46One carbon pool by folate_Homo sapiens_hsa006701.03208737
47Fanconi anemia pathway_Homo sapiens_hsa034601.02492527
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01342813
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01198125
50Propanoate metabolism_Homo sapiens_hsa006401.00800332
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.99719157
52Folate biosynthesis_Homo sapiens_hsa007900.96909393
53RNA transport_Homo sapiens_hsa030130.95945911
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94944371
55Peroxisome_Homo sapiens_hsa041460.92101072
56Rheumatoid arthritis_Homo sapiens_hsa053230.90391846
57Pentose phosphate pathway_Homo sapiens_hsa000300.88368203
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84475227
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83173588
60Glutathione metabolism_Homo sapiens_hsa004800.82349384
61Epstein-Barr virus infection_Homo sapiens_hsa051690.76946924
62Basal transcription factors_Homo sapiens_hsa030220.76588328
63Fructose and mannose metabolism_Homo sapiens_hsa000510.74931059
64Herpes simplex infection_Homo sapiens_hsa051680.74851105
65Metabolic pathways_Homo sapiens_hsa011000.72432682
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.69226955
67Alcoholism_Homo sapiens_hsa050340.67525517
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64650155
69Galactose metabolism_Homo sapiens_hsa000520.63237286
70Shigellosis_Homo sapiens_hsa051310.61161998
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60133451
72Phenylalanine metabolism_Homo sapiens_hsa003600.55383693
73Steroid biosynthesis_Homo sapiens_hsa001000.54328493
74Selenocompound metabolism_Homo sapiens_hsa004500.51768168
75Hematopoietic cell lineage_Homo sapiens_hsa046400.51127079
76Fatty acid metabolism_Homo sapiens_hsa012120.50561065
77Tryptophan metabolism_Homo sapiens_hsa003800.50221093
78Collecting duct acid secretion_Homo sapiens_hsa049660.48067852
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46741502
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46602000
81Arginine and proline metabolism_Homo sapiens_hsa003300.46083454
82Butanoate metabolism_Homo sapiens_hsa006500.44944866
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43376241
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42774083
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40604381
86Regulation of autophagy_Homo sapiens_hsa041400.40296224
87Cell cycle_Homo sapiens_hsa041100.39277782
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.37698882
89Leishmaniasis_Homo sapiens_hsa051400.37411270
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35708840
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.34401366
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32784123
93Fatty acid degradation_Homo sapiens_hsa000710.31875837
94Tyrosine metabolism_Homo sapiens_hsa003500.30735730
95Vibrio cholerae infection_Homo sapiens_hsa051100.30577730
96N-Glycan biosynthesis_Homo sapiens_hsa005100.28600045
97Salmonella infection_Homo sapiens_hsa051320.27663165
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22091369
99Legionellosis_Homo sapiens_hsa051340.21815354
100Viral carcinogenesis_Homo sapiens_hsa052030.20634160

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