UQCRH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.25920822
2* respiratory electron transport chain (GO:0022904)8.50349658
3* electron transport chain (GO:0022900)8.29464835
4ATP biosynthetic process (GO:0006754)5.74602194
5ribosomal large subunit biogenesis (GO:0042273)5.48480873
6purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.23931217
7purine nucleoside triphosphate biosynthetic process (GO:0009145)5.15808837
8* hydrogen ion transmembrane transport (GO:1902600)5.07706794
9chaperone-mediated protein transport (GO:0072321)4.77576896
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.76172043
11mitochondrial respiratory chain complex I assembly (GO:0032981)4.76172043
12NADH dehydrogenase complex assembly (GO:0010257)4.76172043
13viral transcription (GO:0019083)4.75431392
14ribosomal small subunit biogenesis (GO:0042274)4.74262972
15protein complex biogenesis (GO:0070271)4.70822559
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.62646033
17ribonucleoside triphosphate biosynthetic process (GO:0009201)4.53412883
18inner mitochondrial membrane organization (GO:0007007)4.50472155
19translational termination (GO:0006415)4.49605268
20protein neddylation (GO:0045116)4.47754637
21* proton transport (GO:0015992)4.46541010
22* hydrogen transport (GO:0006818)4.39492416
23ribonucleoprotein complex biogenesis (GO:0022613)4.33589475
24proteasome assembly (GO:0043248)4.25673750
25mitochondrial respiratory chain complex assembly (GO:0033108)4.21560583
26nuclear-transcribed mRNA catabolic process (GO:0000956)4.10909284
27formation of translation preinitiation complex (GO:0001731)4.06668861
28cotranslational protein targeting to membrane (GO:0006613)4.05549780
29protein targeting to ER (GO:0045047)3.98216989
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.95385014
31cellular component biogenesis (GO:0044085)3.95078373
32mRNA catabolic process (GO:0006402)3.90165185
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.85886940
34nucleoside triphosphate biosynthetic process (GO:0009142)3.81558392
35protein localization to endoplasmic reticulum (GO:0070972)3.80895088
36* oxidative phosphorylation (GO:0006119)3.79584145
37termination of RNA polymerase III transcription (GO:0006386)3.71316937
38transcription elongation from RNA polymerase III promoter (GO:0006385)3.71316937
39establishment of integrated proviral latency (GO:0075713)3.70971142
40CENP-A containing nucleosome assembly (GO:0034080)3.70229357
41chromatin remodeling at centromere (GO:0031055)3.69571893
42DNA strand elongation involved in DNA replication (GO:0006271)3.67708571
43DNA replication checkpoint (GO:0000076)3.65597508
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.65142989
45RNA catabolic process (GO:0006401)3.61420887
46translational elongation (GO:0006414)3.60247050
47spliceosomal snRNP assembly (GO:0000387)3.55716227
48cellular protein complex disassembly (GO:0043624)3.55395788
49tricarboxylic acid cycle (GO:0006099)3.54948983
50rRNA processing (GO:0006364)3.54645572
51DNA strand elongation (GO:0022616)3.52410456
52telomere maintenance via semi-conservative replication (GO:0032201)3.51811982
53viral life cycle (GO:0019058)3.49877126
54GTP biosynthetic process (GO:0006183)3.46582797
55ribosomal small subunit assembly (GO:0000028)3.38864201
56regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.38761010
57rRNA metabolic process (GO:0016072)3.37784730
58purine nucleobase biosynthetic process (GO:0009113)3.37559966
59negative regulation of ligase activity (GO:0051352)3.36719537
60negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36719537
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35004411
62regulation of oxidative phosphorylation (GO:0002082)3.33923095
63central nervous system myelination (GO:0022010)3.32142893
64axon ensheathment in central nervous system (GO:0032291)3.32142893
65rRNA modification (GO:0000154)3.31800682
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.28654123
67energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.24870919
68ATP hydrolysis coupled proton transport (GO:0015991)3.24870919
69mitochondrial transport (GO:0006839)3.24167771
70pseudouridine synthesis (GO:0001522)3.20285353
71negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.17274306
72purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.12655962
73purine nucleoside monophosphate biosynthetic process (GO:0009127)3.12655962
74* generation of precursor metabolites and energy (GO:0006091)3.11244582
75ribosome biogenesis (GO:0042254)3.08781722
76substantia nigra development (GO:0021762)3.08546002
77nucleobase biosynthetic process (GO:0046112)3.07825169
78positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.07498042
79nucleobase-containing small molecule interconversion (GO:0015949)3.04817598
80establishment of protein localization to membrane (GO:0090150)3.03427331
81protein targeting (GO:0006605)3.01434927
82ribonucleoside monophosphate biosynthetic process (GO:0009156)3.00470680
83DNA replication-independent nucleosome assembly (GO:0006336)3.00131863
84DNA replication-independent nucleosome organization (GO:0034724)3.00131863
85dopamine transport (GO:0015872)2.99100946
86NADH metabolic process (GO:0006734)2.98563588
87nucleoside monophosphate biosynthetic process (GO:0009124)2.98321018
88positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.98293225
89calcium-mediated signaling using intracellular calcium source (GO:0035584)2.97931746
90respiratory chain complex IV assembly (GO:0008535)2.97653560
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96708501
92pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.95473590
93succinate metabolic process (GO:0006105)2.95203141
94histone exchange (GO:0043486)2.94356927
95nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.94113317
96nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92710738
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92700663
98transcription-coupled nucleotide-excision repair (GO:0006283)2.92345822
99establishment of protein localization to organelle (GO:0072594)2.91454544
100regulation of acyl-CoA biosynthetic process (GO:0050812)2.91070636
101fatty acid elongation (GO:0030497)2.89006374
102IMP biosynthetic process (GO:0006188)2.88473640
1037-methylguanosine mRNA capping (GO:0006370)2.88464989
104DNA unwinding involved in DNA replication (GO:0006268)2.87515096
105telomere maintenance via recombination (GO:0000722)2.86367096
106regulation of translational fidelity (GO:0006450)2.85200239
107positive regulation of ligase activity (GO:0051351)2.85141021
108regulation of mitochondrial translation (GO:0070129)2.82519065
109regulation of cell communication by electrical coupling (GO:0010649)2.81422138
110* aerobic respiration (GO:0009060)2.81008052
111maturation of SSU-rRNA (GO:0030490)2.80967657
112purine ribonucleoside biosynthetic process (GO:0046129)2.78551566
113purine nucleoside biosynthetic process (GO:0042451)2.78551566
114protein targeting to membrane (GO:0006612)2.78098027
115protein complex disassembly (GO:0043241)2.76089463
116regulation of cellular respiration (GO:0043457)2.75119226
117negative regulation of protein localization to cell surface (GO:2000009)2.73848623
118translational initiation (GO:0006413)2.72670205
119ubiquinone biosynthetic process (GO:0006744)2.72481984
120quinone biosynthetic process (GO:1901663)2.72481984
121UTP biosynthetic process (GO:0006228)2.71188813
122regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.69178832
123response to epinephrine (GO:0071871)2.68586128
124regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.64482108
125actin-myosin filament sliding (GO:0033275)2.64464290
126muscle filament sliding (GO:0030049)2.64464290
127protein targeting to mitochondrion (GO:0006626)2.64333932
128cytochrome complex assembly (GO:0017004)2.64084198
129regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.63706560
130regulation of relaxation of muscle (GO:1901077)2.63368900
131macromolecular complex disassembly (GO:0032984)2.62346515
132translation (GO:0006412)2.62253391
133regulation of cofactor metabolic process (GO:0051193)2.60307874
134regulation of coenzyme metabolic process (GO:0051196)2.60307874
135sarcomere organization (GO:0045214)2.60281995
136intracellular protein transmembrane import (GO:0044743)2.58774154
137establishment of protein localization to mitochondrion (GO:0072655)2.58464353
138ubiquinone metabolic process (GO:0006743)2.54830668
139heart process (GO:0003015)2.54469525
140heart contraction (GO:0060047)2.54469525
141UTP metabolic process (GO:0046051)2.53508981
142protein localization to mitochondrion (GO:0070585)2.53015760
143cellular response to epinephrine stimulus (GO:0071872)2.51893488
144regulation of catecholamine metabolic process (GO:0042069)2.45155858
145regulation of dopamine metabolic process (GO:0042053)2.45155858
146long-chain fatty acid biosynthetic process (GO:0042759)2.44724526
147regulation of actin filament-based movement (GO:1903115)2.43051326
148regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.42892557
149detection of calcium ion (GO:0005513)2.42178722
150mitochondrial ATP synthesis coupled proton transport (GO:0042776)11.1994605
151ATP synthesis coupled proton transport (GO:0015986)10.4981661
152energy coupled proton transport, down electrochemical gradient (GO:0015985)10.4981661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.72594831
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.85865401
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.62228183
4EZH2_22144423_ChIP-Seq_EOC_Human3.93020427
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.86446171
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.28831074
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.25116260
8MYC_18358816_ChIP-ChIP_MESCs_Mouse3.22494774
9MYC_19030024_ChIP-ChIP_MESCs_Mouse3.00593831
10XRN2_22483619_ChIP-Seq_HELA_Human2.83945292
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.82617682
12TAF15_26573619_Chip-Seq_HEK293_Human2.82066359
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.79135680
14* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.70235159
15VDR_22108803_ChIP-Seq_LS180_Human2.67724294
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66020911
17TTF2_22483619_ChIP-Seq_HELA_Human2.49200565
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45984939
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.44511271
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.36549266
21DCP1A_22483619_ChIP-Seq_HELA_Human2.35291230
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33800004
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.28857893
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28595716
25* ELK1_19687146_ChIP-ChIP_HELA_Human2.26063739
26JARID2_20064375_ChIP-Seq_MESCs_Mouse2.20643919
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20265206
28* GABP_17652178_ChIP-ChIP_JURKAT_Human2.18739070
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15006638
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14920630
31VDR_23849224_ChIP-Seq_CD4+_Human2.13381424
32* FOXP3_21729870_ChIP-Seq_TREG_Human2.11374887
33EZH2_27304074_Chip-Seq_ESCs_Mouse2.06757796
34GBX2_23144817_ChIP-Seq_PC3_Human2.06414565
35BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04004793
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99154420
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96990000
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96574580
39* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.93820857
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.93513430
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91094392
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.90178090
43GABP_19822575_ChIP-Seq_HepG2_Human1.88480871
44* EST1_17652178_ChIP-ChIP_JURKAT_Human1.87849785
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85883926
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82744368
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82011425
48* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81023469
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78066440
50* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76347781
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76252733
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75631864
53AR_21909140_ChIP-Seq_LNCAP_Human1.74918221
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73874566
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.73615603
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.70109505
57FUS_26573619_Chip-Seq_HEK293_Human1.67927324
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.67630454
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.66781159
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.66781159
61* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62680620
62* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62324470
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60200050
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59825837
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.59630881
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59058664
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58535058
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58125803
69* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58097961
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58063291
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55590825
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53856383
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53787644
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52058696
75MYC_18940864_ChIP-ChIP_HL60_Human1.51884409
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50974822
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.50639751
78P300_19829295_ChIP-Seq_ESCs_Human1.45051079
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43926780
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43634589
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.42718329
82* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41953692
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39992172
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39880262
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38116805
86KDM5A_27292631_Chip-Seq_BREAST_Human1.37388036
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36827631
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36812879
89ETS1_20019798_ChIP-Seq_JURKAT_Human1.35344018
90ER_23166858_ChIP-Seq_MCF-7_Human1.35150065
91CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32623676
92ZNF263_19887448_ChIP-Seq_K562_Human1.32096574
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31774100
94EP300_21415370_ChIP-Seq_HL-1_Mouse1.30313097
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29843166
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29163993
97SRF_21415370_ChIP-Seq_HL-1_Mouse1.27445065
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26496790
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24495932
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.20981400
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19873250
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17140331
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16263187
104* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15343937
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14633422
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13398719
107HTT_18923047_ChIP-ChIP_STHdh_Human1.13336312
108AR_21572438_ChIP-Seq_LNCaP_Human1.12185876
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12143303
110ZNF274_21170338_ChIP-Seq_K562_Hela1.08859169
111SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08680255
112IRF1_19129219_ChIP-ChIP_H3396_Human1.08032933
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07891030
114KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07158188
115ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06717899
116SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06637282
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06573155
118SOX2_16153702_ChIP-ChIP_HESCs_Human1.06136377
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05790887
120* ELK1_22589737_ChIP-Seq_MCF10A_Human1.05480273
121* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05345337
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04679194
123SMAD3_21741376_ChIP-Seq_EPCs_Human1.03669468
124IGF1R_20145208_ChIP-Seq_DFB_Human1.03639396
125BCAT_22108803_ChIP-Seq_LS180_Human1.03472024
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03124746
127HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02995289
128* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01825397
129REST_21632747_ChIP-Seq_MESCs_Mouse1.00781868
130RNF2_27304074_Chip-Seq_ESCs_Mouse1.00162373
131RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98617463
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98494169
133* HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97858367
134NANOG_16153702_ChIP-ChIP_HESCs_Human0.96979236
135RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96640298
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94949345
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93361651
138FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92426684
139PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90341060
140CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90133835
141NANOG_19829295_ChIP-Seq_ESCs_Human0.89589289
142SOX2_19829295_ChIP-Seq_ESCs_Human0.89589289
143REST_18959480_ChIP-ChIP_MESCs_Mouse0.89498714
144PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88805917
145* SOX17_20123909_ChIP-Seq_XEN_Mouse0.88669921
146* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88056220
147RNF2_27304074_Chip-Seq_NSC_Mouse0.87788350
148STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87417942
149SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87147735
150* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86470909
151OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85793529
152SMAD4_21799915_ChIP-Seq_A2780_Human0.85663259
153PRDM14_20953172_ChIP-Seq_ESCs_Human0.84878649
154PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84739014
155ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84592962
156NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83945345
157NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83945345
158PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83761071
159CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83456736
160ERG_21242973_ChIP-ChIP_JURKAT_Human0.83395396
161SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83221754
162DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83038405
163CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81743870
164SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81453683
165ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81387601
166CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81378388
167TAL1_26923725_Chip-Seq_HPCs_Mouse0.80949202
168TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80506248
169GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80067515
170JUN_21703547_ChIP-Seq_K562_Human0.79885119
171TP53_18474530_ChIP-ChIP_U2OS_Human0.79405743
172SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79253854
173FLI1_27457419_Chip-Seq_LIVER_Mouse0.78251884
174FOXP1_21924763_ChIP-Seq_HESCs_Human0.76472930
175* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75577760
176CIITA_25753668_ChIP-Seq_RAJI_Human0.74929333
177SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.73199043
178SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72450352
179CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.71605914

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.66786775
2MP0004957_abnormal_blastocyst_morpholog3.98443705
3MP0003880_abnormal_central_pattern3.86291620
4MP0009379_abnormal_foot_pigmentation3.84088456
5MP0003693_abnormal_embryo_hatching3.77753413
6MP0008058_abnormal_DNA_repair3.44039595
7MP0010094_abnormal_chromosome_stability3.40558294
8MP0001529_abnormal_vocalization3.29747113
9MP0003111_abnormal_nucleus_morphology3.25540849
10MP0008932_abnormal_embryonic_tissue2.85229724
11MP0003077_abnormal_cell_cycle2.84279009
12MP0006292_abnormal_olfactory_placode2.77899863
13MP0004215_abnormal_myocardial_fiber2.77523005
14MP0000751_myopathy2.77080286
15MP0003646_muscle_fatigue2.49743633
16MP0006036_abnormal_mitochondrial_physio2.42738234
17MP0001905_abnormal_dopamine_level2.41517382
18MP0004036_abnormal_muscle_relaxation2.41313751
19MP0006276_abnormal_autonomic_nervous2.38460848
20MP0004084_abnormal_cardiac_muscle2.29139611
21MP0003718_maternal_effect2.14804252
22MP0010030_abnormal_orbit_morphology2.12828904
23MP0002938_white_spotting2.11949004
24MP0003806_abnormal_nucleotide_metabolis2.09852542
25MP0000749_muscle_degeneration2.09099734
26MP0008007_abnormal_cellular_replicative2.03815779
27MP0005330_cardiomyopathy2.02666846
28MP0003941_abnormal_skin_development2.01721101
29MP0009697_abnormal_copulation2.00308438
30MP0001440_abnormal_grooming_behavior1.91025142
31MP0002736_abnormal_nociception_after1.89695659
32MP0006035_abnormal_mitochondrial_morpho1.89323818
33MP0008995_early_reproductive_senescence1.89039743
34MP0003786_premature_aging1.88109507
35MP0004484_altered_response_of1.84228581
36MP0003136_yellow_coat_color1.81621589
37MP0004145_abnormal_muscle_electrophysio1.81150772
38MP0002272_abnormal_nervous_system1.80497482
39MP0001968_abnormal_touch/_nociception1.78569563
40MP0004142_abnormal_muscle_tone1.78274882
41MP0002972_abnormal_cardiac_muscle1.77629042
42MP0009745_abnormal_behavioral_response1.75263811
43MP0002064_seizures1.74937492
44MP0003137_abnormal_impulse_conducting1.72651897
45MP0001984_abnormal_olfaction1.64233931
46MP0003123_paternal_imprinting1.63492381
47MP0009046_muscle_twitch1.62856654
48MP0002822_catalepsy1.59339161
49MP0002332_abnormal_exercise_endurance1.58815800
50MP0005620_abnormal_muscle_contractility1.58207635
51MP0004043_abnormal_pH_regulation1.56386286
52MP0004085_abnormal_heartbeat1.54122268
53MP0008057_abnormal_DNA_replication1.50477415
54MP0003635_abnormal_synaptic_transmissio1.50086918
55MP0000350_abnormal_cell_proliferation1.49096152
56MP0002638_abnormal_pupillary_reflex1.45745613
57MP0001293_anophthalmia1.43462875
58MP0001730_embryonic_growth_arrest1.41281877
59MP0003567_abnormal_fetal_cardiomyocyte1.40969759
60MP0002734_abnormal_mechanical_nocicepti1.40837584
61MP0008775_abnormal_heart_ventricle1.40431391
62MP0002572_abnormal_emotion/affect_behav1.39395883
63MP0001486_abnormal_startle_reflex1.37318138
64MP0002163_abnormal_gland_morphology1.34138096
65MP0004270_analgesia1.33283477
66MP0005386_behavior/neurological_phenoty1.31490517
67MP0004924_abnormal_behavior1.31490517
68MP0000566_synostosis1.28264068
69MP0001697_abnormal_embryo_size1.27458870
70MP0001970_abnormal_pain_threshold1.27359107
71MP0003315_abnormal_perineum_morphology1.26473925
72MP0002106_abnormal_muscle_physiology1.25687953
73MP0002735_abnormal_chemical_nociception1.24300611
74MP0001501_abnormal_sleep_pattern1.24111525
75MP0000358_abnormal_cell_content/1.22081933
76MP0000920_abnormal_myelination1.21944580
77MP0000747_muscle_weakness1.21663457
78MP0008789_abnormal_olfactory_epithelium1.21114994
79MP0005409_darkened_coat_color1.21111127
80MP0002210_abnormal_sex_determination1.19600562
81MP0004147_increased_porphyrin_level1.19031370
82MP0005423_abnormal_somatic_nervous1.18991248
83MP0005535_abnormal_body_temperature1.18446333
84MP0002067_abnormal_sensory_capabilities1.17540301
85MP0005385_cardiovascular_system_phenoty1.17158667
86MP0001544_abnormal_cardiovascular_syste1.17158667
87MP0001727_abnormal_embryo_implantation1.16030770
88MP0000750_abnormal_muscle_regeneration1.15938758
89MP0005379_endocrine/exocrine_gland_phen1.15360061
90MP0006138_congestive_heart_failure1.15041997
91MP0003329_amyloid_beta_deposits1.13428066
92MP0002063_abnormal_learning/memory/cond1.11560321
93MP0005380_embryogenesis_phenotype1.10099027
94MP0001672_abnormal_embryogenesis/_devel1.10099027
95MP0005451_abnormal_body_composition1.08957263
96MP0005369_muscle_phenotype1.08467105
97MP0000313_abnormal_cell_death1.07682933
98MP0002733_abnormal_thermal_nociception1.07323031
99MP0002080_prenatal_lethality1.06350907
100MP0002697_abnormal_eye_size1.05271641
101MP0003890_abnormal_embryonic-extraembry1.05193495
102MP0002085_abnormal_embryonic_tissue1.04935098
103MP0004087_abnormal_muscle_fiber1.03359568
104MP0003937_abnormal_limbs/digits/tail_de1.02958001
105MP0000372_irregular_coat_pigmentation1.02155800
106MP0001188_hyperpigmentation1.00858085
107MP0006072_abnormal_retinal_apoptosis1.00633277
108MP0004742_abnormal_vestibular_system1.00214652
109MP0002234_abnormal_pharynx_morphology0.99755753
110MP0000230_abnormal_systemic_arterial0.98303942
111MP0002160_abnormal_reproductive_system0.97976795
112MP0001346_abnormal_lacrimal_gland0.97384828
113MP0003938_abnormal_ear_development0.97374341
114MP0005551_abnormal_eye_electrophysiolog0.96204659
115MP0005499_abnormal_olfactory_system0.96082661
116MP0005394_taste/olfaction_phenotype0.96082661
117MP0001485_abnormal_pinna_reflex0.95053314
118MP0003195_calcinosis0.94652736
119MP0003950_abnormal_plasma_membrane0.94515580
120MP0009672_abnormal_birth_weight0.94200410
121MP0003984_embryonic_growth_retardation0.93905866
122MP0005165_increased_susceptibility_to0.93530390
123MP0001929_abnormal_gametogenesis0.90996763
124MP0005636_abnormal_mineral_homeostasis0.90299468
125MP0002088_abnormal_embryonic_growth/wei0.90276032
126MP0000631_abnormal_neuroendocrine_gland0.90263015
127MP0002084_abnormal_developmental_patter0.89905784
128MP0000049_abnormal_middle_ear0.89832740
129MP0008875_abnormal_xenobiotic_pharmacok0.89787947
130MP0005171_absent_coat_pigmentation0.89785307
131MP0008872_abnormal_physiological_respon0.89535008
132MP0001145_abnormal_male_reproductive0.89194991
133MP0010386_abnormal_urinary_bladder0.89139572
134MP0001286_abnormal_eye_development0.88339164
135MP0003186_abnormal_redox_activity0.87688176
136MP0002127_abnormal_cardiovascular_syste0.87652662
137MP0001664_abnormal_digestion0.86498736
138MP0002184_abnormal_innervation0.86423295
139MP0000537_abnormal_urethra_morphology0.86029286
140MP0004381_abnormal_hair_follicle0.85341705
141MP0003011_delayed_dark_adaptation0.82858206
142MP0000013_abnormal_adipose_tissue0.82667864
143MP0000653_abnormal_sex_gland0.82174074
144MP0002095_abnormal_skin_pigmentation0.81658409
145MP0000778_abnormal_nervous_system0.81320201
146MP0005332_abnormal_amino_acid0.80588515
147MP0003122_maternal_imprinting0.79369442
148MP0002876_abnormal_thyroid_physiology0.78550496
149MP0002066_abnormal_motor_capabilities/c0.77846177
150MP0000759_abnormal_skeletal_muscle0.76861660
151MP0002132_abnormal_respiratory_system0.76496731
152MP0004130_abnormal_muscle_cell0.76103949
153MP0002557_abnormal_social/conspecific_i0.74326595
154MP0005266_abnormal_metabolism0.74062376
155MP0005645_abnormal_hypothalamus_physiol0.74000764
156MP0005187_abnormal_penis_morphology0.73476921
157MP0005408_hypopigmentation0.73093157
158MP0004859_abnormal_synaptic_plasticity0.72721219
159MP0003698_abnormal_male_reproductive0.72464305
160MP0002229_neurodegeneration0.70501751
161MP0003121_genomic_imprinting0.69158202
162MP0008877_abnormal_DNA_methylation0.68197965
163MP0002111_abnormal_tail_morphology0.68053824
164MP0001764_abnormal_homeostasis0.68004360
165MP0001881_abnormal_mammary_gland0.66158390
166MP0002233_abnormal_nose_morphology0.65701216
167MP0002090_abnormal_vision0.64905888
168MP0003942_abnormal_urinary_system0.63464044
169MP0002161_abnormal_fertility/fecundity0.62123740
170MP0000678_abnormal_parathyroid_gland0.61137364
171MP0005410_abnormal_fertilization0.61113150
172MP0000647_abnormal_sebaceous_gland0.61011505
173MP0003119_abnormal_digestive_system0.59890998
174MP0002277_abnormal_respiratory_mucosa0.59127012

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.60395527
2Abnormal mitochondria in muscle tissue (HP:0008316)6.95851714
3Mitochondrial inheritance (HP:0001427)6.52146364
4Progressive macrocephaly (HP:0004481)6.50715784
5Acute encephalopathy (HP:0006846)6.45051201
6Increased CSF lactate (HP:0002490)5.50354472
7Hepatocellular necrosis (HP:0001404)5.38692155
8Increased hepatocellular lipid droplets (HP:0006565)5.23990704
9Lipid accumulation in hepatocytes (HP:0006561)4.91249611
10Hepatic necrosis (HP:0002605)4.88199708
11Cerebral edema (HP:0002181)4.78237240
12Renal Fanconi syndrome (HP:0001994)4.54877068
13Increased intramyocellular lipid droplets (HP:0012240)4.37685178
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.12838667
15Exercise intolerance (HP:0003546)4.03659610
16Increased muscle lipid content (HP:0009058)3.98921266
17Increased serum pyruvate (HP:0003542)3.98269674
18Abnormality of glycolysis (HP:0004366)3.98269674
19Respiratory failure (HP:0002878)3.97110702
20Optic disc pallor (HP:0000543)3.92443675
21Lactic acidosis (HP:0003128)3.81003085
22Leukodystrophy (HP:0002415)3.72197618
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.56848984
24Abnormality of cells of the erythroid lineage (HP:0012130)3.54790547
25Muscle hypertrophy of the lower extremities (HP:0008968)3.51093294
263-Methylglutaconic aciduria (HP:0003535)3.47326175
27Calf muscle hypertrophy (HP:0008981)3.43377521
28Decreased activity of mitochondrial respiratory chain (HP:0008972)3.29579573
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.29579573
30Sudden death (HP:0001699)3.21367895
31Exertional dyspnea (HP:0002875)3.21179557
32Increased serum lactate (HP:0002151)3.09798918
33Respiratory difficulties (HP:0002880)3.07957531
34Abnormality of renal resorption (HP:0011038)2.94518076
35Abnormal number of erythroid precursors (HP:0012131)2.92849802
36Neuroendocrine neoplasm (HP:0100634)2.90834882
37Microvesicular hepatic steatosis (HP:0001414)2.81547415
38Pheochromocytoma (HP:0002666)2.81528865
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.80535498
40X-linked dominant inheritance (HP:0001423)2.78328278
41Birth length less than 3rd percentile (HP:0003561)2.74212017
42Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.73359730
43Abnormality of urine glucose concentration (HP:0011016)2.64851477
44Glycosuria (HP:0003076)2.64851477
45Parakeratosis (HP:0001036)2.62814161
46Aplastic anemia (HP:0001915)2.58221822
47Hyperphosphaturia (HP:0003109)2.54016188
48Abnormality of reticulocytes (HP:0004312)2.53731457
49Lethargy (HP:0001254)2.47475046
50Degeneration of anterior horn cells (HP:0002398)2.45950118
51Abnormality of the anterior horn cell (HP:0006802)2.45950118
52Exercise-induced myalgia (HP:0003738)2.45101926
53Cerebral hemorrhage (HP:0001342)2.43346216
54Conjunctival hamartoma (HP:0100780)2.40780691
55Macrocytic anemia (HP:0001972)2.39197169
56Palpitations (HP:0001962)2.37593692
57Multiple enchondromatosis (HP:0005701)2.33809231
58Exercise-induced muscle cramps (HP:0003710)2.32863178
59Abnormality of the calf musculature (HP:0001430)2.30699574
60CNS demyelination (HP:0007305)2.29021996
61Abnormal urine phosphate concentration (HP:0012599)2.18775958
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16738531
63Generalized aminoaciduria (HP:0002909)2.12814638
64Progressive muscle weakness (HP:0003323)2.12457623
65Ventricular tachycardia (HP:0004756)2.12150755
66Emotional lability (HP:0000712)2.11348348
67Chromsome breakage (HP:0040012)2.11184225
68Oral leukoplakia (HP:0002745)2.10898196
69Myoglobinuria (HP:0002913)2.07463838
70Myokymia (HP:0002411)2.05769223
71Colon cancer (HP:0003003)2.04231862
72Type I transferrin isoform profile (HP:0003642)2.01739724
73Dicarboxylic aciduria (HP:0003215)2.00938979
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00938979
75Muscle stiffness (HP:0003552)2.00334092
76Vomiting (HP:0002013)2.00291486
77Meckel diverticulum (HP:0002245)1.99550368
78Methylmalonic aciduria (HP:0012120)1.99500879
79Absent thumb (HP:0009777)1.99253028
80Triphalangeal thumb (HP:0001199)1.99227985
81Muscle fiber splitting (HP:0003555)1.96314344
82Abnormality of methionine metabolism (HP:0010901)1.96105618
83Myotonia (HP:0002486)1.95828237
84Methylmalonic acidemia (HP:0002912)1.94637450
85Syncope (HP:0001279)1.94129770
86Focal motor seizures (HP:0011153)1.93280372
87Cerebral hypomyelination (HP:0006808)1.92750113
88Reticulocytopenia (HP:0001896)1.92638220
89Congenital ichthyosiform erythroderma (HP:0007431)1.92468999
90Hypoplastic left heart (HP:0004383)1.91638175
91Pancytopenia (HP:0001876)1.89098809
92Abnormality of the labia minora (HP:0012880)1.88655993
93Renal tubular dysfunction (HP:0000124)1.88655862
94Rhabdomyolysis (HP:0003201)1.85598039
95Abnormality of the preputium (HP:0100587)1.85273755
96Atrial fibrillation (HP:0005110)1.85264224
97Congenital, generalized hypertrichosis (HP:0004540)1.85016748
98Lipoatrophy (HP:0100578)1.84229692
99Retinal dysplasia (HP:0007973)1.83570667
100Septo-optic dysplasia (HP:0100842)1.83241794
101Aplasia/Hypoplasia of the uvula (HP:0010293)1.82307688
102Abnormality of the ileum (HP:0001549)1.81756700
103Hypothermia (HP:0002045)1.80483653
104Abnormal pupillary function (HP:0007686)1.79846235
105Supraventricular tachycardia (HP:0004755)1.79567672
106Sensory axonal neuropathy (HP:0003390)1.77922728
107Abnormality of cochlea (HP:0000375)1.76585338
108Primary atrial arrhythmia (HP:0001692)1.76311461
109Gout (HP:0001997)1.76129786
110Depressed nasal ridge (HP:0000457)1.74315137
111Supraventricular arrhythmia (HP:0005115)1.72284666
112Nausea (HP:0002018)1.72081670
113Abnormal ciliary motility (HP:0012262)1.71459416
114Megaloblastic anemia (HP:0001889)1.71344944
115Prolonged QT interval (HP:0001657)1.71302699
116Abnormality of serum amino acid levels (HP:0003112)1.71153748
117Limb dystonia (HP:0002451)1.69406296
118Ragged-red muscle fibers (HP:0003200)1.69242519
119Ketoacidosis (HP:0001993)1.68914842
120Homocystinuria (HP:0002156)1.68741925
121Abnormality of homocysteine metabolism (HP:0010919)1.68741925
122Blindness (HP:0000618)1.66889801
123Abnormality of alanine metabolism (HP:0010916)1.66304272
124Hyperalaninemia (HP:0003348)1.66304272
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66304272
126Abnormal number of incisors (HP:0011064)1.66011734
127Pallor (HP:0000980)1.65655923
128Absent septum pellucidum (HP:0001331)1.65440236
129Cholecystitis (HP:0001082)1.64613438
130Abnormal gallbladder physiology (HP:0012438)1.64613438
131Hyperglycinemia (HP:0002154)1.64537675
132Dilated cardiomyopathy (HP:0001644)1.64373979
133Testicular atrophy (HP:0000029)1.64263527
134Amniotic constriction ring (HP:0009775)1.61814352
135Abnormality of placental membranes (HP:0011409)1.61814352
136Sparse eyelashes (HP:0000653)1.61601573
137Partial duplication of thumb phalanx (HP:0009944)1.60568832
138Abnormal hemoglobin (HP:0011902)1.60419269
139Abnormal lung lobation (HP:0002101)1.59225252
140Anxiety (HP:0000739)1.58789967
141Atonic seizures (HP:0010819)1.58555877
142Gliosis (HP:0002171)1.58444262
143Horseshoe kidney (HP:0000085)1.58164063
144Reduced antithrombin III activity (HP:0001976)1.57823584
145Abnormality of the axillary hair (HP:0100134)1.57754007
146Abnormality of secondary sexual hair (HP:0009888)1.57754007
147Abnormality of sulfur amino acid metabolism (HP:0004339)1.56230371
148Partial duplication of the phalanx of hand (HP:0009999)1.55572700
149Hypoplasia of the pons (HP:0012110)1.54481265
150Abnormality of chromosome stability (HP:0003220)1.53279210

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.66560369
2VRK24.37219235
3CDC73.77587472
4STK393.41489098
5MYLK3.33994215
6NME13.21995109
7MAP3K123.18304423
8SRPK12.93632022
9MST42.82694232
10NEK12.81612464
11TTK2.81242579
12OBSCN2.80021976
13EIF2AK12.72141983
14MUSK2.68183467
15NME22.56640073
16WNK42.54772318
17OXSR12.52771099
18ZAK2.50282232
19GRK72.45415707
20WEE12.15262052
21PNCK2.10704128
22ARAF1.99216989
23PLK41.97554619
24GRK51.94925216
25PLK31.74350274
26CDK191.71526319
27MAP2K71.68107728
28PBK1.66432471
29PHKG21.59568979
30PHKG11.59568979
31TSSK61.58988400
32BCKDK1.58519316
33CASK1.58466292
34MAP3K41.54158216
35MAPKAPK51.53203540
36CHEK21.43002019
37STK161.40064015
38PLK11.37402681
39PDK41.36272718
40PDK31.36272718
41TNIK1.33290604
42CAMK2D1.32486461
43MKNK11.32232237
44BCR1.31486132
45BMPR1B1.29709882
46PASK1.29150862
47AURKB1.28360031
48CAMK2A1.27750012
49MAP2K41.25795019
50LIMK11.24044613
51EPHA41.23131761
52ADRBK21.21915659
53FGR1.21163118
54BRSK21.19994618
55STK41.19224826
56CCNB11.18880904
57LMTK21.18205502
58CAMK2B1.17311970
59PTK2B1.16741622
60ILK1.14517812
61PIK3CA1.14218196
62TLK11.14128237
63EIF2AK31.13463686
64NTRK31.12571384
65BRSK11.10701858
66PKN11.09874967
67AURKA1.08730473
68ATR1.07822992
69DYRK31.06090326
70UHMK11.04325472
71TIE11.03987905
72TAF11.03149060
73ROCK21.02412666
74BMPR21.02278017
75ADRBK11.01515829
76PAK31.01102108
77NEK21.00733374
78CAMK2G1.00273764
79WNK30.98800459
80RIPK40.98639616
81CSNK2A20.96099352
82MST1R0.95513850
83RPS6KB20.91384410
84PRKCE0.89970233
85PDK20.89587493
86STK240.85959403
87MAPK130.85039846
88CDK80.83518663
89PLK20.82207809
90ABL20.81702570
91DAPK30.80908143
92CSNK2A10.79595426
93PRKACA0.76900028
94CHEK10.76797630
95VRK10.76390754
96BRAF0.76077350
97TTN0.75457505
98MAPK120.75405502
99MARK10.75034967
100PAK40.71409820
101CDK70.71395250
102CSNK1G30.71291085
103GRK60.69019068
104RPS6KA50.67133668
105CSNK1E0.66462988
106ALK0.65038276
107CLK10.63369412
108PAK10.62141422
109MKNK20.62105118
110PINK10.61824301
111TESK20.60174199
112MINK10.60048229
113NUAK10.59563817
114MAP3K80.57316752
115GRK10.55920858
116ATM0.55176581
117PRKCQ0.55121403
118CDK10.53508298
119KDR0.52881062
120RPS6KA40.52807863
121CDK50.52748455
122CDK20.51069977
123PIM20.50796238
124NTRK20.48178790
125DYRK20.48163010
126CSNK1G20.47917966
127WNK10.47505418
128CDK11A0.47196597
129CAMK10.46625378
130AKT20.45296128
131NTRK10.44038202
132CDK30.43957861
133MAPK40.43889589
134PRKCG0.43422403
135PIK3CG0.43247833
136ROCK10.43200840
137SCYL20.42535940
138FES0.42078345
139IRAK20.42060419
140CDK150.41962389
141PRKD10.41678011
142LRRK20.41014081
143EIF2AK20.40417388
144DAPK10.40298918
145PRKG10.39228010
146CDK180.38706773
147MAPK150.37845133
148BMX0.36600416
149PRKCA0.35455192
150MAP2K10.34638928
151CDK140.34490177
152LATS20.34105688
153CSNK1G10.34103715
154PRKACB0.33519882
155RAF10.32857169
156PRKDC0.31920209
157INSRR0.29305877
158PRKACG0.29293307
159MET0.28829099
160ERBB40.28779072
161PRKCI0.28137195
162PIM10.26651672
163CDK40.25365747
164MAP3K100.25164779

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.72014238
2Parkinsons disease_Homo sapiens_hsa050125.72993407
3Alzheimers disease_Homo sapiens_hsa050104.45304581
4Huntingtons disease_Homo sapiens_hsa050163.89379263
5* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.67719770
6Ribosome_Homo sapiens_hsa030103.63352564
7* Cardiac muscle contraction_Homo sapiens_hsa042603.43535694
8DNA replication_Homo sapiens_hsa030303.31216709
9Mismatch repair_Homo sapiens_hsa034303.08169478
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.56369321
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42061789
12Spliceosome_Homo sapiens_hsa030402.32048504
13Homologous recombination_Homo sapiens_hsa034402.24010147
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16647659
15Proteasome_Homo sapiens_hsa030502.15337742
16Fatty acid elongation_Homo sapiens_hsa000622.01401056
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94313371
18Nucleotide excision repair_Homo sapiens_hsa034201.93732625
19One carbon pool by folate_Homo sapiens_hsa006701.90109075
20Propanoate metabolism_Homo sapiens_hsa006401.87557668
21Base excision repair_Homo sapiens_hsa034101.84064224
22Collecting duct acid secretion_Homo sapiens_hsa049661.82668043
23Protein export_Homo sapiens_hsa030601.79301917
24RNA transport_Homo sapiens_hsa030131.77467813
25Pyruvate metabolism_Homo sapiens_hsa006201.54625846
26Sulfur metabolism_Homo sapiens_hsa009201.45330462
27Fanconi anemia pathway_Homo sapiens_hsa034601.37996756
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36650745
29RNA degradation_Homo sapiens_hsa030181.34250800
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33079397
31Butanoate metabolism_Homo sapiens_hsa006501.32752260
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32749132
33Cell cycle_Homo sapiens_hsa041101.32547120
34Basal transcription factors_Homo sapiens_hsa030221.30450539
35Sulfur relay system_Homo sapiens_hsa041221.24563743
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23546982
37Folate biosynthesis_Homo sapiens_hsa007901.19560466
38Non-homologous end-joining_Homo sapiens_hsa034501.16473187
39Nicotine addiction_Homo sapiens_hsa050331.14756935
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04990238
41RNA polymerase_Homo sapiens_hsa030201.03480520
42Vibrio cholerae infection_Homo sapiens_hsa051101.03089967
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02828271
44Carbon metabolism_Homo sapiens_hsa012000.98708782
45Fatty acid degradation_Homo sapiens_hsa000710.93778972
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92850517
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90926221
48Phenylalanine metabolism_Homo sapiens_hsa003600.89496260
49Tyrosine metabolism_Homo sapiens_hsa003500.89278542
50Serotonergic synapse_Homo sapiens_hsa047260.88248414
51Fatty acid metabolism_Homo sapiens_hsa012120.86614925
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82804851
53* Metabolic pathways_Homo sapiens_hsa011000.81934576
54GABAergic synapse_Homo sapiens_hsa047270.78008216
55mRNA surveillance pathway_Homo sapiens_hsa030150.77388100
56Taste transduction_Homo sapiens_hsa047420.71411504
57Peroxisome_Homo sapiens_hsa041460.71380976
58Dilated cardiomyopathy_Homo sapiens_hsa054140.70650265
59Histidine metabolism_Homo sapiens_hsa003400.68703310
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68248839
61Glutathione metabolism_Homo sapiens_hsa004800.67932209
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67101584
63Synaptic vesicle cycle_Homo sapiens_hsa047210.66047500
64Pentose phosphate pathway_Homo sapiens_hsa000300.64755027
65Selenocompound metabolism_Homo sapiens_hsa004500.64749854
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62513430
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62109850
68Ether lipid metabolism_Homo sapiens_hsa005650.58024890
69Rheumatoid arthritis_Homo sapiens_hsa053230.57307029
70Arginine and proline metabolism_Homo sapiens_hsa003300.56498232
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56384465
72Morphine addiction_Homo sapiens_hsa050320.55862913
73Phototransduction_Homo sapiens_hsa047440.55500811
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55282655
75Calcium signaling pathway_Homo sapiens_hsa040200.52953660
76Oocyte meiosis_Homo sapiens_hsa041140.52042223
77Glutamatergic synapse_Homo sapiens_hsa047240.52010089
78Renin secretion_Homo sapiens_hsa049240.51841361
79beta-Alanine metabolism_Homo sapiens_hsa004100.51603914
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50284459
81Steroid biosynthesis_Homo sapiens_hsa001000.49991818
82Vitamin B6 metabolism_Homo sapiens_hsa007500.49563215
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49322331
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49105669
85Chemical carcinogenesis_Homo sapiens_hsa052040.48209306
86Circadian entrainment_Homo sapiens_hsa047130.46875731
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46783210
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46054580
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45318518
90Systemic lupus erythematosus_Homo sapiens_hsa053220.45014862
91Fructose and mannose metabolism_Homo sapiens_hsa000510.44317752
92Arginine biosynthesis_Homo sapiens_hsa002200.44118058
93Arachidonic acid metabolism_Homo sapiens_hsa005900.43852565
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43827104
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43573741
96Nitrogen metabolism_Homo sapiens_hsa009100.43507275
97Gastric acid secretion_Homo sapiens_hsa049710.43113612
98Dopaminergic synapse_Homo sapiens_hsa047280.41379059
99Linoleic acid metabolism_Homo sapiens_hsa005910.40828865
100Salivary secretion_Homo sapiens_hsa049700.39796764
101PPAR signaling pathway_Homo sapiens_hsa033200.35809569
102Alcoholism_Homo sapiens_hsa050340.34447825
103Amphetamine addiction_Homo sapiens_hsa050310.32971478
104Olfactory transduction_Homo sapiens_hsa047400.32420981
105p53 signaling pathway_Homo sapiens_hsa041150.31722121
106Long-term depression_Homo sapiens_hsa047300.31145572
107N-Glycan biosynthesis_Homo sapiens_hsa005100.30513261
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.30455497
109Tryptophan metabolism_Homo sapiens_hsa003800.30059470
110Cholinergic synapse_Homo sapiens_hsa047250.29861476
111Epstein-Barr virus infection_Homo sapiens_hsa051690.27711500
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27412341
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.27069650
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27040233
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26788999
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26781675
117Pancreatic secretion_Homo sapiens_hsa049720.26003455
118Oxytocin signaling pathway_Homo sapiens_hsa049210.25985247
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24862064
120Galactose metabolism_Homo sapiens_hsa000520.24830459
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.23392250
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.22994629
123Purine metabolism_Homo sapiens_hsa002300.22917863
124Pyrimidine metabolism_Homo sapiens_hsa002400.21440913
125Mineral absorption_Homo sapiens_hsa049780.21408956
126Cocaine addiction_Homo sapiens_hsa050300.20471803
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19985424
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19369505
129Vitamin digestion and absorption_Homo sapiens_hsa049770.18908378
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17143064
131Phagosome_Homo sapiens_hsa041450.16612520
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15968396
133Sphingolipid metabolism_Homo sapiens_hsa006000.15192929
134Fat digestion and absorption_Homo sapiens_hsa049750.15062749
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.14920226
136Long-term potentiation_Homo sapiens_hsa047200.14374999
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14217306
138Basal cell carcinoma_Homo sapiens_hsa052170.12578741
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.12058922
140Insulin secretion_Homo sapiens_hsa049110.10706760
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.09733823
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.08419548
143Biosynthesis of amino acids_Homo sapiens_hsa012300.08122601
144Cyanoamino acid metabolism_Homo sapiens_hsa004600.04689642
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.04111416
146Thyroid cancer_Homo sapiens_hsa052160.00207355

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