URAD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)8.17682154
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.65337610
3L-phenylalanine catabolic process (GO:0006559)7.65337610
4L-phenylalanine metabolic process (GO:0006558)7.31834111
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.31834111
6aromatic amino acid family catabolic process (GO:0009074)6.91068656
7regulation of guanylate cyclase activity (GO:0031282)6.82290362
8NADH metabolic process (GO:0006734)6.57453655
9regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.46309177
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.30442851
11tryptophan catabolic process (GO:0006569)6.25745935
12indole-containing compound catabolic process (GO:0042436)6.25745935
13indolalkylamine catabolic process (GO:0046218)6.25745935
14kynurenine metabolic process (GO:0070189)6.10997843
15bile acid biosynthetic process (GO:0006699)6.01022010
16tryptophan metabolic process (GO:0006568)5.87697703
17glyoxylate metabolic process (GO:0046487)5.81995052
18urea cycle (GO:0000050)5.81143889
19urea metabolic process (GO:0019627)5.81143889
20negative regulation of fibrinolysis (GO:0051918)5.72044488
21high-density lipoprotein particle remodeling (GO:0034375)5.61271410
22regulation of fibrinolysis (GO:0051917)5.52941780
23complement activation, alternative pathway (GO:0006957)5.51297062
24regulation of protein activation cascade (GO:2000257)5.48377727
25protein carboxylation (GO:0018214)5.47080575
26peptidyl-glutamic acid carboxylation (GO:0017187)5.47080575
27intestinal absorption (GO:0050892)5.46976692
28alpha-linolenic acid metabolic process (GO:0036109)5.44125516
29sulfur amino acid catabolic process (GO:0000098)5.38539605
30cysteine metabolic process (GO:0006534)5.35608937
31nitrogen cycle metabolic process (GO:0071941)5.34150431
32serine family amino acid catabolic process (GO:0009071)5.18253503
33regulation of complement activation (GO:0030449)5.12691388
34bile acid metabolic process (GO:0008206)5.12477316
35aromatic amino acid family metabolic process (GO:0009072)5.01880432
36positive regulation of guanylate cyclase activity (GO:0031284)4.94714885
37reverse cholesterol transport (GO:0043691)4.89763819
38regulation of cholesterol esterification (GO:0010872)4.87379195
39tyrosine metabolic process (GO:0006570)4.86187524
40regulation of triglyceride catabolic process (GO:0010896)4.84873014
41homocysteine metabolic process (GO:0050667)4.83533322
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.79724085
43epoxygenase P450 pathway (GO:0019373)4.79672648
44plasma lipoprotein particle remodeling (GO:0034369)4.77788766
45protein-lipid complex remodeling (GO:0034368)4.77788766
46macromolecular complex remodeling (GO:0034367)4.77788766
47fat-soluble vitamin biosynthetic process (GO:0042362)4.76894347
48regulation of systemic arterial blood pressure by hormone (GO:0001990)4.75238099
49regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.75238099
50endocrine process (GO:0050886)4.75238099
51alpha-amino acid catabolic process (GO:1901606)4.68651159
52lysine catabolic process (GO:0006554)4.61268394
53lysine metabolic process (GO:0006553)4.61268394
54acylglycerol homeostasis (GO:0055090)4.60861903
55triglyceride homeostasis (GO:0070328)4.60861903
56amino-acid betaine metabolic process (GO:0006577)4.60141482
57antibacterial humoral response (GO:0019731)4.56548895
58regulation of cellular extravasation (GO:0002691)4.56407060
59phospholipid efflux (GO:0033700)4.53667572
60negative regulation of sterol transport (GO:0032372)4.50171193
61negative regulation of cholesterol transport (GO:0032375)4.50171193
62glycine metabolic process (GO:0006544)4.46350739
63lipoprotein transport (GO:0042953)4.44325798
64coenzyme catabolic process (GO:0009109)4.43450872
65cellular ketone body metabolic process (GO:0046950)4.43228944
66antimicrobial humoral response (GO:0019730)4.42861634
67indolalkylamine metabolic process (GO:0006586)4.42442596
68bile acid and bile salt transport (GO:0015721)4.40128049
69virion attachment to host cell (GO:0019062)4.38650573
70adhesion of symbiont to host cell (GO:0044650)4.38650573
71regulation of systemic arterial blood pressure (GO:0003073)4.37972956
72plasma lipoprotein particle clearance (GO:0034381)4.36792639
73fructose metabolic process (GO:0006000)4.36786718
74imidazole-containing compound metabolic process (GO:0052803)4.35978858
75cellular biogenic amine catabolic process (GO:0042402)4.33356984
76amine catabolic process (GO:0009310)4.33356984
77positive regulation of respiratory burst (GO:0060267)4.31144715
78cellular amino acid catabolic process (GO:0009063)4.30665102
79cellular glucuronidation (GO:0052695)4.30472023
80quinone biosynthetic process (GO:1901663)4.29035039
81positive regulation of pseudopodium assembly (GO:0031274)4.27228575
82diacylglycerol metabolic process (GO:0046339)4.26668152
83glutamate metabolic process (GO:0006536)4.24737486
84hormone catabolic process (GO:0042447)4.23792197
85regulation of cGMP biosynthetic process (GO:0030826)4.21012417
86serine family amino acid metabolic process (GO:0009069)4.20325966
87cholesterol efflux (GO:0033344)4.19377850
88benzene-containing compound metabolic process (GO:0042537)4.15918769
89receptor guanylyl cyclase signaling pathway (GO:0007168)4.14210081
90arginine metabolic process (GO:0006525)4.12487353
91cellular modified amino acid catabolic process (GO:0042219)4.08925944
92fibrinolysis (GO:0042730)4.07798315
93ethanol oxidation (GO:0006069)4.06351235
94glycerol metabolic process (GO:0006071)4.06266969
95dicarboxylic acid biosynthetic process (GO:0043650)4.03827999
96serine family amino acid biosynthetic process (GO:0009070)4.03141774
97aldehyde catabolic process (GO:0046185)4.01670441
98drug catabolic process (GO:0042737)3.99091213
99nucleoside diphosphate biosynthetic process (GO:0009133)3.98732081
100renal system process involved in regulation of blood volume (GO:0001977)3.98472285
101low-density lipoprotein particle remodeling (GO:0034374)3.96833548
102plasma lipoprotein particle assembly (GO:0034377)3.96336205
103peptide catabolic process (GO:0043171)3.94867955
104blood coagulation, intrinsic pathway (GO:0007597)3.94117016
105complement activation, classical pathway (GO:0006958)3.87797610
106positive regulation of protein homodimerization activity (GO:0090073)3.85120586
107drug metabolic process (GO:0017144)3.84650323
108complement activation (GO:0006956)3.84205770
109cofactor catabolic process (GO:0051187)3.84107733
110ketone body metabolic process (GO:1902224)3.83618121
111protein activation cascade (GO:0072376)3.82103743
112glucuronate metabolic process (GO:0019585)3.81943436
113uronic acid metabolic process (GO:0006063)3.81943436
114regulation of pseudopodium assembly (GO:0031272)3.81833222
115cytolysis (GO:0019835)3.78264106
116positive regulation of lipoprotein lipase activity (GO:0051006)3.78231157
117positive regulation of triglyceride lipase activity (GO:0061365)3.78231157
118antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.77867180
119regulation of bile acid biosynthetic process (GO:0070857)3.76510992
120negative regulation of lipase activity (GO:0060192)3.74602927
121organic acid catabolic process (GO:0016054)3.74278395
122carboxylic acid catabolic process (GO:0046395)3.74278395
123adhesion of symbiont to host (GO:0044406)3.74174967
124cholesterol homeostasis (GO:0042632)3.73619385
125phospholipid homeostasis (GO:0055091)3.72836985
126positive regulation of lipid catabolic process (GO:0050996)3.70171981
127sterol homeostasis (GO:0055092)3.67340480
128acetyl-CoA metabolic process (GO:0006084)3.66952409
129cellular response to arsenic-containing substance (GO:0071243)3.66805126
130alditol metabolic process (GO:0019400)3.66369835
131very-low-density lipoprotein particle assembly (GO:0034379)3.64143465
132short-chain fatty acid metabolic process (GO:0046459)3.61873764
133plasma lipoprotein particle organization (GO:0071827)3.61500591
134antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.60474645
135acute-phase response (GO:0006953)3.59410388
136NAD biosynthetic process (GO:0009435)3.58096037
137regulation of cholesterol homeostasis (GO:2000188)3.58037945
138exogenous drug catabolic process (GO:0042738)3.57922201
139glomerular filtration (GO:0003094)3.56376216
140oligosaccharide biosynthetic process (GO:0009312)3.55957930
141regulation of respiratory burst (GO:0060263)3.53387968
142regulation of dendritic cell antigen processing and presentation (GO:0002604)3.47211876
143germinal center formation (GO:0002467)3.46366617
144antigen processing and presentation of endogenous antigen (GO:0019883)3.45672545
145regulation of vitamin metabolic process (GO:0030656)3.44629261
146regulation of cGMP metabolic process (GO:0030823)3.42093998
147segment specification (GO:0007379)3.40545659
148maintenance of gastrointestinal epithelium (GO:0030277)3.25046456
149cellular response to nitric oxide (GO:0071732)3.22431546
150cGMP-mediated signaling (GO:0019934)3.20907883
151renal filtration (GO:0097205)3.18335330
152transcytosis (GO:0045056)3.17827116
153peptide hormone processing (GO:0016486)3.17588144
154phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.16484180
155calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.15174154
156sexual reproduction (GO:0019953)3.15161382
157digestion (GO:0007586)3.15005913
158thyroid gland development (GO:0030878)3.05943225
159leukotriene metabolic process (GO:0006691)3.02893231
160response to nitric oxide (GO:0071731)3.02154037
161glycine transport (GO:0015816)3.00907351
162triglyceride biosynthetic process (GO:0019432)2.97497994
163carnitine shuttle (GO:0006853)2.95235565
164positive regulation of cGMP biosynthetic process (GO:0030828)2.91867518
165positive regulation of glycoprotein biosynthetic process (GO:0010560)2.90477024
166alkaloid metabolic process (GO:0009820)2.89677712
167acylglycerol biosynthetic process (GO:0046463)2.87736947
168neutral lipid biosynthetic process (GO:0046460)2.87736947
169eosinophil chemotaxis (GO:0048245)2.87324353
170vitamin transmembrane transport (GO:0035461)2.86741706
171ncRNA catabolic process (GO:0034661)2.86377301
172flavonoid metabolic process (GO:0009812)2.85043716
173renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.84917867
174hexose catabolic process (GO:0019320)2.83854159
175cranial nerve morphogenesis (GO:0021602)2.83077448
176cellular response to fluid shear stress (GO:0071498)2.81298674
177stress granule assembly (GO:0034063)2.76470540
178receptor recycling (GO:0001881)2.76404866
179oxaloacetate metabolic process (GO:0006107)2.75459343
180sulfate transmembrane transport (GO:1902358)2.74767549
181ketone biosynthetic process (GO:0042181)2.74293411
182digestive system process (GO:0022600)2.73891710
183quinone metabolic process (GO:1901661)2.73420235
184positive regulation of antigen processing and presentation (GO:0002579)2.73044262
185glucocorticoid biosynthetic process (GO:0006704)2.72857610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.39815674
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.18502587
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.11610459
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.48852510
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.30938069
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.18372523
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.81448528
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.05718247
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.05476215
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.42954381
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.23023581
12SOX2_20726797_ChIP-Seq_SW620_Human2.21554689
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.13946340
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06659969
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0637073
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97796912
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92134960
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87659833
19TET1_21451524_ChIP-Seq_MESCs_Mouse1.86250790
20IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64414195
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64063778
22FOXA2_19822575_ChIP-Seq_HepG2_Human1.59682325
23HTT_18923047_ChIP-ChIP_STHdh_Human1.58025394
24CLOCK_20551151_ChIP-Seq_293T_Human1.51008712
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47183293
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.45636642
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44717117
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43904861
29CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42815536
30P63_26484246_Chip-Seq_KERATINOCYTES_Human1.41005858
31VDR_24763502_ChIP-Seq_THP-1_Human1.40859095
32HNF4A_19822575_ChIP-Seq_HepG2_Human1.39807153
33GATA1_22025678_ChIP-Seq_K562_Human1.38713165
34VDR_21846776_ChIP-Seq_THP-1_Human1.36650247
35BCOR_27268052_Chip-Seq_Bcells_Human1.35823500
36SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30347102
37RACK7_27058665_Chip-Seq_MCF-7_Human1.29816152
38SA1_27219007_Chip-Seq_Bcells_Human1.29174232
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29173743
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28764080
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.28418837
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26126805
43CTCF_27219007_Chip-Seq_Bcells_Human1.24961785
44JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.24268013
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23504812
46STAT1_20625510_ChIP-Seq_HELA_Human1.22226692
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22014721
48BCL6_27268052_Chip-Seq_Bcells_Human1.21812099
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21785059
50CREB1_26743006_Chip-Seq_LNCaP_Human1.21253915
51RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20682454
52CTCF_26484167_Chip-Seq_Bcells_Mouse1.19224582
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18255427
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16881674
55ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13533858
56KLF5_25053715_ChIP-Seq_YYC3_Human1.10928928
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09787724
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.09402355
59OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08880035
60ETS1_21867929_ChIP-Seq_TH2_Mouse1.08601353
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08571751
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08547413
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08501539
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.06865876
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05450654
66CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03572086
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03391873
68NANOG_20526341_ChIP-Seq_ESCs_Human1.02283172
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01435810
70RUNX1_27514584_Chip-Seq_MCF-7_Human1.01414713
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00998943
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00813352
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00767935
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99539376
75CDX2_22108803_ChIP-Seq_LS180_Human0.95598631
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93704644
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93313862
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93042146
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92755709
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92448593
81E2F1_20622854_ChIP-Seq_HELA_Human0.92205266
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91382155
83FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91141528
84SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89536083
85TCF7_22412390_ChIP-Seq_EML_Mouse0.89274866
86TP63_22573176_ChIP-Seq_HFKS_Human0.89161867
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88763486
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84550308
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83991832
90IRF8_22096565_ChIP-ChIP_GC-B_Human0.81430938
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80754910
92RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80283286
93KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79148260
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78625467
95GATA4_25053715_ChIP-Seq_YYC3_Human0.78575284
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76794814
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75342694
98ZNF263_19887448_ChIP-Seq_K562_Human0.74908687
99RARA_24833708_ChIP-Seq_LIVER_Mouse0.74420578
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73510211
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69909748
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.69437351
103AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65831981
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65598642
105ESR2_21235772_ChIP-Seq_MCF-7_Human0.65092243
106RARB_24833708_ChIP-Seq_LIVER_Mouse0.64458060
107RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63680241
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.63277768
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62910742
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62910742
111RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61795735
112BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60546693
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60312443
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59707307
115CEBPB_22108803_ChIP-Seq_LS180_Human0.56915550
116EGR1_19032775_ChIP-ChIP_M12_Human0.54511146
117E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.54459451
118AR_20517297_ChIP-Seq_VCAP_Human0.52741510
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52405829
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52097359
121FOXA1_25552417_ChIP-Seq_VCAP_Human0.51917379
122LXR_22292898_ChIP-Seq_THP-1_Human0.51784071
123MYC_19915707_ChIP-ChIP_AK7_Human0.50750780
124FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50438182
125FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49116137
126ESET_19884257_ChIP-Seq_ESCs_Mouse0.48492915
127CBP_21632823_ChIP-Seq_H3396_Human0.47325388
128STAT1_17558387_ChIP-Seq_HELA_Human0.46779094
129P53_21459846_ChIP-Seq_SAOS-2_Human0.46595871
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.44493859
131PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44187752
132ESR1_21235772_ChIP-Seq_MCF-7_Human0.43947996
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42856371
134TAF15_26573619_Chip-Seq_HEK293_Human0.42591875
135TAF2_19829295_ChIP-Seq_ESCs_Human0.41859578
136PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.41788028
137SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40644547
138GATA1_19941827_ChIP-Seq_MEL_Mouse0.40452057
139FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.40132746
140ERG_21242973_ChIP-ChIP_JURKAT_Human0.39707813
141GATA1_19941826_ChIP-Seq_K562_Human0.39657740
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.39496148
143FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39458656
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39328256
145BCAT_22108803_ChIP-Seq_LS180_Human0.38340938
146MYC_27129775_Chip-Seq_CORNEA_Mouse0.37964202
147GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.37806827
148GATA6_25053715_ChIP-Seq_YYC3_Human0.37706004
149GATA2_19941826_ChIP-Seq_K562_Human0.37485537
150STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37290742
151SPI1_26923725_Chip-Seq_HPCs_Mouse0.36150878
152ESR1_20079471_ChIP-ChIP_T-47D_Human0.36043836
153PPAR_26484153_Chip-Seq_NCI-H1993_Human0.36036692
154LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35866188
155SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34861915
156ERG_20517297_ChIP-Seq_VCAP_Human0.34221767
157CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34035137
158NCOR_22424771_ChIP-Seq_293T_Human0.33684215
159FOXH1_21741376_ChIP-Seq_EPCs_Human0.33504657

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.23890323
2MP0005360_urolithiasis7.64302834
3MP0005085_abnormal_gallbladder_physiolo6.44565689
4MP0005365_abnormal_bile_salt6.14189843
5MP0008875_abnormal_xenobiotic_pharmacok5.19740441
6MP0003806_abnormal_nucleotide_metabolis4.28147529
7MP0003252_abnormal_bile_duct3.85132900
8MP0009379_abnormal_foot_pigmentation3.82507033
9MP0010329_abnormal_lipoprotein_level3.58799653
10MP0009840_abnormal_foam_cell3.33111197
11MP0003183_abnormal_peptide_metabolism3.19993384
12MP0005083_abnormal_biliary_tract3.08203084
13MP0000490_abnormal_crypts_of3.04647501
14MP0010155_abnormal_intestine_physiology3.00476416
15MP0003195_calcinosis2.84465858
16MP0005332_abnormal_amino_acid2.78323632
17MP0010234_abnormal_vibrissa_follicle2.66108770
18MP0002009_preneoplasia2.63757883
19MP0001666_abnormal_nutrient_absorption2.57683030
20MP0003191_abnormal_cellular_cholesterol2.40393006
21MP0004264_abnormal_extraembryonic_tissu2.37686540
22MP0005409_darkened_coat_color2.29991136
23MP0009333_abnormal_splenocyte_physiolog2.16167788
24MP0000609_abnormal_liver_physiology2.15821986
25MP0004019_abnormal_vitamin_homeostasis2.12345264
26MP0002118_abnormal_lipid_homeostasis2.08648779
27MP0003866_abnormal_defecation1.96020559
28MP0001664_abnormal_digestion1.94746182
29MP0003868_abnormal_feces_composition1.94485181
30MP0002138_abnormal_hepatobiliary_system1.94321424
31MP0001873_stomach_inflammation1.93759779
32MP0004147_increased_porphyrin_level1.89998077
33MP0000477_abnormal_intestine_morphology1.86383295
34MP0000678_abnormal_parathyroid_gland1.85893182
35MP0000681_abnormal_thyroid_gland1.84564763
36MP0002166_altered_tumor_susceptibility1.84272326
37MP0005319_abnormal_enzyme/_coenzyme1.83609206
38MP0001764_abnormal_homeostasis1.70333415
39MP0009697_abnormal_copulation1.62054141
40MP0010352_gastrointestinal_tract_polyps1.61653551
41MP0002249_abnormal_larynx_morphology1.60150362
42MP0005584_abnormal_enzyme/coenzyme_acti1.56849481
43MP0003763_abnormal_thymus_physiology1.56452335
44MP0000015_abnormal_ear_pigmentation1.52158336
45MP0005174_abnormal_tail_pigmentation1.44740418
46MP0001663_abnormal_digestive_system1.44163002
47MP0005451_abnormal_body_composition1.42269844
48MP0001765_abnormal_ion_homeostasis1.40328212
49MP0003011_delayed_dark_adaptation1.38650074
50MP0002006_tumorigenesis1.33294272
51MP0003186_abnormal_redox_activity1.26963488
52MP0003656_abnormal_erythrocyte_physiolo1.26715223
53MP0005381_digestive/alimentary_phenotyp1.24751304
54MP0009643_abnormal_urine_homeostasis1.22367509
55MP0000462_abnormal_digestive_system1.21382766
56MP0000598_abnormal_liver_morphology1.18428886
57MP0003705_abnormal_hypodermis_morpholog1.18114804
58MP0005647_abnormal_sex_gland1.15331116
59MP0009785_altered_susceptibility_to1.12829875
60MP0001835_abnormal_antigen_presentation1.10682301
61MP0000604_amyloidosis1.10470239
62MP0003172_abnormal_lysosome_physiology1.08112315
63MP0001849_ear_inflammation1.07979964
64MP0009764_decreased_sensitivity_to1.06833204
65MP0000566_synostosis1.05557753
66MP0004043_abnormal_pH_regulation1.03645306
67MP0009763_increased_sensitivity_to1.03316212
68MP0004858_abnormal_nervous_system1.01955342
69MP0010368_abnormal_lymphatic_system1.00796897
70MP0002254_reproductive_system_inflammat1.00084405
71MP0005375_adipose_tissue_phenotype0.98366892
72MP0002098_abnormal_vibrissa_morphology0.95308165
73MP0001188_hyperpigmentation0.92753745
74MP0005058_abnormal_lysosome_morphology0.91853812
75MP0005636_abnormal_mineral_homeostasis0.91245404
76MP0003879_abnormal_hair_cell0.91060188
77MP0001790_abnormal_immune_system0.91054342
78MP0005387_immune_system_phenotype0.91054342
79MP0008469_abnormal_protein_level0.90119637
80MP0005025_abnormal_response_to0.88503760
81MP0009642_abnormal_blood_homeostasis0.87094379
82MP0001501_abnormal_sleep_pattern0.86655235
83MP0005408_hypopigmentation0.86592287
84MP0000538_abnormal_urinary_bladder0.86385405
85MP0001800_abnormal_humoral_immune0.84126151
86MP0000013_abnormal_adipose_tissue0.83651426
87MP0008007_abnormal_cellular_replicative0.83405141
88MP0005670_abnormal_white_adipose0.81904539
89MP0006036_abnormal_mitochondrial_physio0.81074817
90MP0005376_homeostasis/metabolism_phenot0.80572160
91MP0009765_abnormal_xenobiotic_induced0.79128510
92MP0002148_abnormal_hypersensitivity_rea0.78195370
93MP0002078_abnormal_glucose_homeostasis0.76037951
94MP0002876_abnormal_thyroid_physiology0.75834280
95MP0005084_abnormal_gallbladder_morpholo0.75765685
96MP0000465_gastrointestinal_hemorrhage0.75261218
97MP0005220_abnormal_exocrine_pancreas0.73216705
98MP0002971_abnormal_brown_adipose0.70386637
99MP0006138_congestive_heart_failure0.70340709
100MP0009053_abnormal_anal_canal0.68211808
101MP0003690_abnormal_glial_cell0.67605649
102MP0008004_abnormal_stomach_pH0.67422391
103MP0005535_abnormal_body_temperature0.67168161
104MP0004130_abnormal_muscle_cell0.66854612
105MP0003303_peritoneal_inflammation0.66715485
106MP0005334_abnormal_fat_pad0.66590370
107MP0001661_extended_life_span0.66109788
108MP0004084_abnormal_cardiac_muscle0.66046054
109MP0005266_abnormal_metabolism0.64463529
110MP0003315_abnormal_perineum_morphology0.64428044
111MP0005000_abnormal_immune_tolerance0.63754185
112MP0003329_amyloid_beta_deposits0.63535548
113MP0000639_abnormal_adrenal_gland0.62365053
114MP0001756_abnormal_urination0.57042292
115MP0006035_abnormal_mitochondrial_morpho0.54421856
116MP0005448_abnormal_energy_balance0.54070324
117MP0005464_abnormal_platelet_physiology0.53933456
118MP0005395_other_phenotype0.50222413
119MP0002822_catalepsy0.50164185
120MP0003718_maternal_effect0.49373953
121MP0008874_decreased_physiological_sensi0.46886365
122MP0003638_abnormal_response/metabolism_0.46109337
123MP0004782_abnormal_surfactant_physiolog0.46051552
124MP0008873_increased_physiological_sensi0.45629861
125MP0003436_decreased_susceptibility_to0.44050599
126MP0002136_abnormal_kidney_physiology0.43246196
127MP0002928_abnormal_bile_duct0.42555947
128MP0003724_increased_susceptibility_to0.42439638
129MP0003075_altered_response_to0.42041350
130MP0008872_abnormal_physiological_respon0.40918833
131MP0005166_decreased_susceptibility_to0.40168156
132MP0005248_abnormal_Harderian_gland0.40076473
133MP0002837_dystrophic_cardiac_calcinosis0.40045180
134MP0004381_abnormal_hair_follicle0.39116834
135MP0003953_abnormal_hormone_level0.39091949
136MP0000579_abnormal_nail_morphology0.38607315
137MP0009672_abnormal_birth_weight0.37764276
138MP0005666_abnormal_adipose_tissue0.35716681
139MP0009384_cardiac_valve_regurgitation0.34952006
140MP0000249_abnormal_blood_vessel0.32749310
141MP0004883_abnormal_blood_vessel0.32500130
142MP0002796_impaired_skin_barrier0.32280026
143MP0001243_abnormal_dermal_layer0.31786580
144MP0009115_abnormal_fat_cell0.31557833
145MP0006082_CNS_inflammation0.30140235
146MP0000230_abnormal_systemic_arterial0.29881737
147MP0002168_other_aberrant_phenotype0.29672145
148MP0002970_abnormal_white_adipose0.29641019
149MP0001881_abnormal_mammary_gland0.28879913
150MP0001845_abnormal_inflammatory_respons0.27921458
151MP0002132_abnormal_respiratory_system0.27511821
152MP0001853_heart_inflammation0.27394086
153MP0005164_abnormal_response_to0.25409178
154MP0002060_abnormal_skin_morphology0.24144638
155MP0002090_abnormal_vision0.23513268

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.53860397
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.47678995
3Intrahepatic cholestasis (HP:0001406)7.36256094
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.75605969
5Prolonged partial thromboplastin time (HP:0003645)6.71458499
6Hypobetalipoproteinemia (HP:0003563)6.37448998
7Xanthomatosis (HP:0000991)6.23559804
8Hyperlipoproteinemia (HP:0010980)5.62056007
9Complement deficiency (HP:0004431)5.60036682
10Joint hemorrhage (HP:0005261)4.90628481
11Hypolipoproteinemia (HP:0010981)4.81463239
12Hyperammonemia (HP:0001987)4.64597474
13Abnormality of the common coagulation pathway (HP:0010990)4.55822038
14Epidermoid cyst (HP:0200040)4.45793901
15Hyperglycinemia (HP:0002154)4.44820264
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.40221029
17Abnormality of methionine metabolism (HP:0010901)4.37613776
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.31739245
19Widely patent fontanelles and sutures (HP:0004492)4.25245092
20Hypoalphalipoproteinemia (HP:0003233)4.24751248
21Ketosis (HP:0001946)4.24175556
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.19273860
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.18977764
24Fat malabsorption (HP:0002630)4.12804461
25Abnormality of complement system (HP:0005339)4.09386395
26Decreased circulating renin level (HP:0003351)4.06264153
27Metabolic alkalosis (HP:0200114)4.05149286
28Abnormality of pyrimidine metabolism (HP:0004353)3.94116958
29Hyperglycinuria (HP:0003108)3.90408125
30Abnormality of glycine metabolism (HP:0010895)3.90011311
31Abnormality of serine family amino acid metabolism (HP:0010894)3.90011311
32Abnormality of the intrinsic pathway (HP:0010989)3.86699068
33Abnormality of the vitamin B12 metabolism (HP:0004341)3.79581680
34Hypoglycemic coma (HP:0001325)3.78379110
35Chronic diarrhea (HP:0002028)3.76259127
36Hyperactive renin-angiotensin system (HP:0000841)3.73309938
37Ileus (HP:0002595)3.71642727
38Conjugated hyperbilirubinemia (HP:0002908)3.65311460
39Pustule (HP:0200039)3.64148411
40Hypercholesterolemia (HP:0003124)3.56247257
41Abnormality of vitamin B metabolism (HP:0004340)3.52874891
42Cerebral palsy (HP:0100021)3.40618384
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32803528
44Hyperbilirubinemia (HP:0002904)3.32113677
45Reduced antithrombin III activity (HP:0001976)3.29119135
46Abnormality of renin-angiotensin system (HP:0000847)3.29078341
47Abnormality of fatty-acid metabolism (HP:0004359)3.28661784
48Wide cranial sutures (HP:0010537)3.18679228
49Steatorrhea (HP:0002570)3.15229800
50Spontaneous abortion (HP:0005268)3.15160813
51Rhabdomyolysis (HP:0003201)3.13324227
52Abnormality of serum amino acid levels (HP:0003112)3.11942236
53Delayed CNS myelination (HP:0002188)3.08845195
54Confusion (HP:0001289)3.08502563
55Abnormality of nucleobase metabolism (HP:0010932)3.07761434
56Abnormality of urine glucose concentration (HP:0011016)3.03090045
57Glycosuria (HP:0003076)3.03090045
58Hepatocellular carcinoma (HP:0001402)2.97295949
59Ketoacidosis (HP:0001993)2.95987008
60Myocardial infarction (HP:0001658)2.95792388
61Congenital sensorineural hearing impairment (HP:0008527)2.94069328
62Hypochromic microcytic anemia (HP:0004840)2.93844109
63Systemic lupus erythematosus (HP:0002725)2.82575720
64Nausea (HP:0002018)2.81886404
65Inflammation of the large intestine (HP:0002037)2.81234282
66Skin nodule (HP:0200036)2.76270095
67Metabolic acidosis (HP:0001942)2.74605893
68Gastrointestinal inflammation (HP:0004386)2.73894853
69Nephrolithiasis (HP:0000787)2.67175053
70Abnormality of purine metabolism (HP:0004352)2.64583673
71Lethargy (HP:0001254)2.62695747
72Cheilitis (HP:0100825)2.57196130
73Vascular calcification (HP:0004934)2.55504388
74Dicarboxylic aciduria (HP:0003215)2.55105422
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55105422
76Glomerulonephritis (HP:0000099)2.52998899
77Recurrent gram-negative bacterial infections (HP:0005420)2.50701702
78Hyperparathyroidism (HP:0000843)2.48212100
79Spastic diplegia (HP:0001264)2.48125877
80Acanthocytosis (HP:0001927)2.47798328
81Cerebral edema (HP:0002181)2.46785003
82Posterior subcapsular cataract (HP:0007787)2.45556208
83Abnormal gallbladder morphology (HP:0012437)2.43124631
84Type I transferrin isoform profile (HP:0003642)2.43012985
85Neonatal onset (HP:0003623)2.42072022
86Growth hormone excess (HP:0000845)2.41966513
87Gout (HP:0001997)2.41819852
88Premature loss of primary teeth (HP:0006323)2.41651546
89Hyperphosphaturia (HP:0003109)2.41500571
90Pigmentary retinal degeneration (HP:0001146)2.40892481
91Mitral stenosis (HP:0001718)2.40627545
92Abdominal distention (HP:0003270)2.40260784
93Hypoglycemic seizures (HP:0002173)2.40044144
94Irritability (HP:0000737)2.37122989
95J-shaped sella turcica (HP:0002680)2.36829545
96Cholelithiasis (HP:0001081)2.36782399
97Amyloidosis (HP:0011034)2.36098925
98Cervical subluxation (HP:0003308)2.34441694
99Gingivitis (HP:0000230)2.31767099
100Abnormal biliary tract morphology (HP:0012440)2.30496479
101Thin bony cortex (HP:0002753)2.29774586
102Gingival bleeding (HP:0000225)2.27727742
103Cholecystitis (HP:0001082)2.27430228
104Abnormal gallbladder physiology (HP:0012438)2.27430228
105Hypotension (HP:0002615)2.27265968
106Abnormal urine phosphate concentration (HP:0012599)2.27241340
107Cardiovascular calcification (HP:0011915)2.26396611
108Abnormality of placental membranes (HP:0011409)2.21936906
109Amniotic constriction ring (HP:0009775)2.21936906
110Osteomalacia (HP:0002749)2.21271531
111Malnutrition (HP:0004395)2.20777985
112Esophageal varix (HP:0002040)2.19434942
113Menorrhagia (HP:0000132)2.19022663
114Myoglobinuria (HP:0002913)2.18789555
115Facial shape deformation (HP:0011334)2.14447389
116Potter facies (HP:0002009)2.14447389
117Hypokalemia (HP:0002900)2.13679995
118Thrombophlebitis (HP:0004418)2.13219013
119Sensorimotor neuropathy (HP:0007141)2.13123188
120Pancreatitis (HP:0001733)2.13087942
121Flat acetabular roof (HP:0003180)2.11727076
122Chronic sinusitis (HP:0011109)2.10967179
123Agammaglobulinemia (HP:0004432)2.10519263
124Proximal tubulopathy (HP:0000114)2.10159893
125Enlarged kidneys (HP:0000105)2.09717613
126Brushfield spots (HP:0001088)2.09394717
127Late onset (HP:0003584)2.07701881
128Vomiting (HP:0002013)2.06939631
129Eczematoid dermatitis (HP:0000976)2.06822047
130Abnormality of the costochondral junction (HP:0000919)2.05939972
131Hyperuricemia (HP:0002149)2.03810072
132Increased purine levels (HP:0004368)2.03810072
133Abnormal tarsal ossification (HP:0008369)2.02540199
134Opisthotonus (HP:0002179)2.02492699
135Abnormality of small intestinal villus morphology (HP:0011472)2.01827681
136Villous atrophy (HP:0011473)2.01827681
137Periodontitis (HP:0000704)2.01317089
138Hypophosphatemia (HP:0002148)2.01093023
139Xerostomia (HP:0000217)2.00618506
140Petechiae (HP:0000967)1.98872879
141Abnormality of the gallbladder (HP:0005264)1.98477080
142Hemorrhage of the eye (HP:0011885)1.98374800
143Generalized aminoaciduria (HP:0002909)1.98302325
144Abnormality of potassium homeostasis (HP:0011042)1.96239194
145Poikilocytosis (HP:0004447)1.96131325
146Hyperinsulinemic hypoglycemia (HP:0000825)1.93825974
147Pili torti (HP:0003777)1.92256252
148Abnormality of iron homeostasis (HP:0011031)1.88953774
149Rickets (HP:0002748)1.87578264
150Hyperaldosteronism (HP:0000859)1.86859827
151Increased muscle lipid content (HP:0009058)1.86198624
152Abnormality of transition element cation homeostasis (HP:0011030)1.85770396
153Abnormal cartilage morphology (HP:0002763)1.85408113
154Ankyloglossia (HP:0010296)1.84884196
155Alkalosis (HP:0001948)1.83716242
156Hypophosphatemic rickets (HP:0004912)1.82052096
157Abnormality of proline metabolism (HP:0010907)1.81968044
158Hydroxyprolinuria (HP:0003080)1.81968044
159Status epilepticus (HP:0002133)1.81314345
160Abnormal enzyme/coenzyme activity (HP:0012379)1.80578445
161Renal cortical cysts (HP:0000803)1.80401303
162Elevated hepatic transaminases (HP:0002910)1.80358496
163Abnormal hair laboratory examination (HP:0003328)1.79034997
164Nephritis (HP:0000123)1.78573417
165Flared iliac wings (HP:0002869)1.77650495
166Megaloblastic anemia (HP:0001889)1.77635033
167Right ventricular cardiomyopathy (HP:0011663)1.77627283
168Syncope (HP:0001279)1.77369550
169Abnormality of vitamin metabolism (HP:0100508)1.73347384
170Hyperglycemia (HP:0003074)1.72593435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.27985152
2ACVR1B6.86516482
3FGFR44.68874243
4ERN14.54389843
5SIK14.45392194
6EPHA23.64323341
7ERBB43.14817439
8TAOK33.11621864
9INSRR2.82743412
10PRKG22.44267334
11MAP2K42.38138055
12EPHB22.20233729
13PKN22.18353520
14MST1R2.10556881
15SYK1.98597365
16MAPK111.95973571
17CDK31.91630552
18FLT31.85342371
19TRIB31.82206183
20RIPK41.77916881
21TYK21.71817455
22PIK3CG1.71299249
23LATS11.65541862
24CDK191.58005827
25ABL21.52856561
26DAPK21.52642155
27PTK61.48158449
28KIT1.44360012
29LMTK21.39394987
30NEK91.38735939
31CAMKK21.35589318
32FGFR21.32721536
33KDR1.30930080
34FRK1.26399340
35JAK21.25461450
36DDR21.20368817
37MAP3K71.18592357
38MATK1.18450714
39STK391.15913272
40TNK21.15385531
41TESK21.14502038
42MAP4K11.13482650
43PINK11.13037487
44PDK21.13033377
45GRK61.12592277
46PRKAA21.11070249
47ERBB21.08543616
48MAP2K31.06056306
49TBK11.06036589
50JAK11.00409269
51MAPK40.98801154
52CDC42BPA0.98093300
53MAP3K100.98044644
54DMPK0.92721125
55MAP3K140.92014471
56PRKCZ0.91831331
57STK38L0.90714458
58EPHB10.90349675
59EPHA30.87094577
60MYLK0.86472416
61MET0.85686725
62MAP3K30.83260452
63MAPK120.82147936
64MAP3K110.80681540
65MAP3K120.80502895
66YES10.79769029
67CDK60.79666766
68JAK30.77409381
69OXSR10.76681062
70MAPK150.76607915
71TIE10.76349602
72PRKACG0.76123418
73CAMK2G0.75742017
74PRPF4B0.71700544
75CAMKK10.71699903
76VRK10.70932765
77PIM20.70192628
78HCK0.69385299
79MAP3K20.68571693
80MAP2K60.68527022
81DYRK1B0.68013956
82SMG10.67239352
83CSK0.66947399
84PRKCD0.65871849
85NME20.65688049
86GSK3A0.65686018
87PRKAA10.64017498
88ITK0.61602267
89TAOK10.60209027
90SGK30.59653355
91RIPK10.59138697
92CAMK1D0.58844222
93IRAK30.57342037
94VRK20.57012831
95MAPK70.56942445
96IKBKE0.56735476
97PIM10.56649571
98FGFR30.56476135
99STK240.56017077
100FER0.55554970
101TGFBR20.55283302
102PTK20.54434579
103CSF1R0.54049858
104TESK10.52323409
105SRC0.51967187
106EPHA40.50363462
107PDPK10.50041634
108PRKCQ0.49697565
109PKN10.48093385
110TAOK20.47973109
111FYN0.47130878
112CSNK1G10.46910622
113PRKCE0.46061018
114MAP3K130.45121243
115IKBKB0.44897352
116MAP3K50.44397063
117IGF1R0.42976992
118SGK20.42688318
119RET0.42672030
120MAP2K10.42461961
121GRK10.42096644
122CDK40.41774925
123MAP3K60.41416253
124PRKCG0.41161752
125ICK0.37961065
126PBK0.35761157
127CAMK2D0.35278305
128EGFR0.34855687
129LATS20.33925652
130MTOR0.33663686
131TNIK0.32425039
132PRKCI0.32354018
133CAMK40.32114017
134NLK0.32071539
135LRRK20.31118408
136BTK0.29634467
137LYN0.29525957
138PDK10.29216602
139SGK2230.29145392
140SGK4940.29145392
141GRK50.28153039
142CSNK1G20.27889471
143MAP3K10.26786503
144PRKCA0.25998833
145IRAK10.25968041
146CSNK1G30.25731741
147IRAK20.22235161
148ABL10.21508670
149BMX0.20963131
150PIK3CA0.20612642
151MAP2K20.20189696
152PAK30.19939916
153AKT30.18470468

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.58486566
2Nitrogen metabolism_Homo sapiens_hsa009103.59503624
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.45871872
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34609100
5Arginine biosynthesis_Homo sapiens_hsa002203.13417237
6Complement and coagulation cascades_Homo sapiens_hsa046102.83810440
7Mineral absorption_Homo sapiens_hsa049782.72910005
8Tryptophan metabolism_Homo sapiens_hsa003802.69754878
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63206869
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59985408
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56824667
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.56642594
13Fatty acid degradation_Homo sapiens_hsa000712.42867689
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34753220
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22797585
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15170769
17Butanoate metabolism_Homo sapiens_hsa006502.11282427
18Peroxisome_Homo sapiens_hsa041462.04948123
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.98618471
20Chemical carcinogenesis_Homo sapiens_hsa052041.97067806
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94383657
22Caffeine metabolism_Homo sapiens_hsa002321.90036645
23Propanoate metabolism_Homo sapiens_hsa006401.88884245
24Histidine metabolism_Homo sapiens_hsa003401.88508131
25Protein digestion and absorption_Homo sapiens_hsa049741.87590481
26PPAR signaling pathway_Homo sapiens_hsa033201.82754700
27Staphylococcus aureus infection_Homo sapiens_hsa051501.80299428
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.78885253
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.76766002
30Fatty acid metabolism_Homo sapiens_hsa012121.74543161
31Asthma_Homo sapiens_hsa053101.71854373
32Retinol metabolism_Homo sapiens_hsa008301.70837551
33beta-Alanine metabolism_Homo sapiens_hsa004101.67588259
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63396314
35Phenylalanine metabolism_Homo sapiens_hsa003601.58870852
36Selenocompound metabolism_Homo sapiens_hsa004501.58733202
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57894128
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53312872
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52307936
40Bile secretion_Homo sapiens_hsa049761.47728446
41Tyrosine metabolism_Homo sapiens_hsa003501.44952362
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.41342285
43Sulfur metabolism_Homo sapiens_hsa009201.36046783
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.35537995
45Allograft rejection_Homo sapiens_hsa053301.34875559
46Pyruvate metabolism_Homo sapiens_hsa006201.33034583
47Fatty acid elongation_Homo sapiens_hsa000621.27385784
48Starch and sucrose metabolism_Homo sapiens_hsa005001.26989585
49Type I diabetes mellitus_Homo sapiens_hsa049401.25417594
50Biosynthesis of amino acids_Homo sapiens_hsa012301.22633152
51Folate biosynthesis_Homo sapiens_hsa007901.21930131
52Steroid biosynthesis_Homo sapiens_hsa001001.20918719
53ABC transporters_Homo sapiens_hsa020101.15244214
54Fat digestion and absorption_Homo sapiens_hsa049751.14032519
55Autoimmune thyroid disease_Homo sapiens_hsa053201.11904158
56Carbon metabolism_Homo sapiens_hsa012001.11357115
57Graft-versus-host disease_Homo sapiens_hsa053321.07593040
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04189818
59Maturity onset diabetes of the young_Homo sapiens_hsa049501.00300781
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.98761603
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98679770
62Sulfur relay system_Homo sapiens_hsa041220.97065349
63Arginine and proline metabolism_Homo sapiens_hsa003300.96177117
64Vitamin B6 metabolism_Homo sapiens_hsa007500.94113460
65Pancreatic secretion_Homo sapiens_hsa049720.92716886
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87050636
67Vitamin digestion and absorption_Homo sapiens_hsa049770.83199812
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82061543
69Lysine degradation_Homo sapiens_hsa003100.78402685
70One carbon pool by folate_Homo sapiens_hsa006700.76897424
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70337662
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68176808
73Glycerolipid metabolism_Homo sapiens_hsa005610.64308669
74Glutathione metabolism_Homo sapiens_hsa004800.63817603
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58583930
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58566021
77Pentose phosphate pathway_Homo sapiens_hsa000300.57332287
78Renin secretion_Homo sapiens_hsa049240.54627261
79Other glycan degradation_Homo sapiens_hsa005110.53887105
80Leishmaniasis_Homo sapiens_hsa051400.50301004
81Fatty acid biosynthesis_Homo sapiens_hsa000610.49666642
82Antigen processing and presentation_Homo sapiens_hsa046120.46521066
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45744691
84* Metabolic pathways_Homo sapiens_hsa011000.45375926
85N-Glycan biosynthesis_Homo sapiens_hsa005100.42637076
86Pertussis_Homo sapiens_hsa051330.41476994
87Prion diseases_Homo sapiens_hsa050200.40624927
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39045971
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31427136
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30695629
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29857441
92Viral myocarditis_Homo sapiens_hsa054160.29602189
93Primary immunodeficiency_Homo sapiens_hsa053400.27148484
94Linoleic acid metabolism_Homo sapiens_hsa005910.24575435
95Galactose metabolism_Homo sapiens_hsa000520.24117697
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23383769
97Fructose and mannose metabolism_Homo sapiens_hsa000510.23206361
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22804425
99Insulin resistance_Homo sapiens_hsa049310.21753797
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.20394520
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19724897
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.16947393
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15450876
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.15009412
105Hematopoietic cell lineage_Homo sapiens_hsa046400.14312656
106Rheumatoid arthritis_Homo sapiens_hsa053230.12987318
107Sphingolipid metabolism_Homo sapiens_hsa006000.10514419
108Toxoplasmosis_Homo sapiens_hsa051450.09545418
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.09362693
110Lysosome_Homo sapiens_hsa041420.08886536
111Glucagon signaling pathway_Homo sapiens_hsa049220.08647118
112AMPK signaling pathway_Homo sapiens_hsa041520.01051767
113Bladder cancer_Homo sapiens_hsa05219-0.2459035
114Ether lipid metabolism_Homo sapiens_hsa00565-0.2449023
115Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2433293
116Amoebiasis_Homo sapiens_hsa05146-0.2292818
117Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2290625
118Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1945346
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1893350
120Renin-angiotensin system_Homo sapiens_hsa04614-0.1884306
121Hepatitis C_Homo sapiens_hsa05160-0.1782904
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1775655
123Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1675757
124Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1608017
125Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1591541
126Regulation of autophagy_Homo sapiens_hsa04140-0.1357762
127African trypanosomiasis_Homo sapiens_hsa05143-0.1307415
128Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1202519
129Insulin signaling pathway_Homo sapiens_hsa04910-0.1121643
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0876955
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0758079
132Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0550285
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0420477

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