URB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.36767117
2nuclear pore organization (GO:0006999)6.24547116
3pore complex assembly (GO:0046931)4.80979992
4mitotic nuclear envelope disassembly (GO:0007077)4.64518229
5nuclear envelope disassembly (GO:0051081)4.34808560
6membrane disassembly (GO:0030397)4.34808560
7DNA replication-dependent nucleosome assembly (GO:0006335)4.27904532
8DNA replication-dependent nucleosome organization (GO:0034723)4.27904532
9regulation of histone H3-K9 methylation (GO:0051570)4.27080002
10pre-miRNA processing (GO:0031054)4.26718511
11protein localization to kinetochore (GO:0034501)4.25906916
12DNA unwinding involved in DNA replication (GO:0006268)4.18334413
13regulation of gene silencing by RNA (GO:0060966)4.11538809
14regulation of posttranscriptional gene silencing (GO:0060147)4.11538809
15regulation of gene silencing by miRNA (GO:0060964)4.11538809
16hemidesmosome assembly (GO:0031581)4.10685130
17positive regulation of transcription from RNA polymerase III promoter (GO:0045945)4.08396860
18heterochromatin organization (GO:0070828)4.06772881
19folic acid-containing compound biosynthetic process (GO:0009396)4.06694974
20piRNA metabolic process (GO:0034587)4.01972019
21IMP biosynthetic process (GO:0006188)3.96657908
22negative regulation of histone methylation (GO:0031061)3.90968369
23mitotic sister chromatid cohesion (GO:0007064)3.90177734
24nucleobase biosynthetic process (GO:0046112)3.85383839
25glucocorticoid receptor signaling pathway (GO:0042921)3.82072464
26DNA duplex unwinding (GO:0032508)3.79989505
27protein localization to chromosome, centromeric region (GO:0071459)3.79214413
28DNA geometric change (GO:0032392)3.78794699
29gene silencing by RNA (GO:0031047)3.68401192
30DNA replication initiation (GO:0006270)3.66850460
31regulation of RNA export from nucleus (GO:0046831)3.65978938
32regulation of translational fidelity (GO:0006450)3.58328522
33regulation of translational termination (GO:0006449)3.57033211
34chromatin assembly (GO:0031497)3.56295834
35mitotic chromosome condensation (GO:0007076)3.56016588
36mitotic sister chromatid segregation (GO:0000070)3.53457196
37synaptonemal complex assembly (GO:0007130)3.51343858
38sister chromatid segregation (GO:0000819)3.49480422
39formation of translation preinitiation complex (GO:0001731)3.46309328
40snRNA processing (GO:0016180)3.43956069
41cell-substrate junction assembly (GO:0007044)3.43673175
42snRNA metabolic process (GO:0016073)3.41002143
43cellular protein complex localization (GO:0034629)3.37887426
44nuclear envelope organization (GO:0006998)3.36753363
45dosage compensation (GO:0007549)3.36437352
46regulation of centriole replication (GO:0046599)3.33343216
47IMP metabolic process (GO:0046040)3.33218805
48mitotic metaphase plate congression (GO:0007080)3.32244733
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.28595751
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28595751
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.24419459
52gene silencing (GO:0016458)3.24127460
53positive regulation of chromosome segregation (GO:0051984)3.23828757
54male meiosis (GO:0007140)3.23227386
55protein complex localization (GO:0031503)3.21843954
56translesion synthesis (GO:0019985)3.20772660
57regulation of helicase activity (GO:0051095)3.19979117
58ribosome assembly (GO:0042255)3.19795247
59synaptonemal complex organization (GO:0070193)3.19730469
60adherens junction assembly (GO:0034333)3.18867048
61DNA strand elongation involved in DNA replication (GO:0006271)3.18712103
62cell-substrate adherens junction assembly (GO:0007045)3.17400148
63focal adhesion assembly (GO:0048041)3.17400148
64histone H2A monoubiquitination (GO:0035518)3.16934855
65mRNA transport (GO:0051028)3.16785003
66regulation of centrosome cycle (GO:0046605)3.16382754
67establishment of apical/basal cell polarity (GO:0035089)3.15638829
68spliceosomal tri-snRNP complex assembly (GO:0000244)3.13333765
69regulation of spindle organization (GO:0090224)3.12900480
70attachment of spindle microtubules to kinetochore (GO:0008608)3.12701630
71DNA conformation change (GO:0071103)3.12602036
72chromatin assembly or disassembly (GO:0006333)3.10553417
73maturation of SSU-rRNA (GO:0030490)3.09617840
74purine nucleobase biosynthetic process (GO:0009113)3.09310498
75peptidyl-lysine dimethylation (GO:0018027)3.09017773
76ribosome biogenesis (GO:0042254)3.08225573
77corticosteroid receptor signaling pathway (GO:0031958)3.07549566
78DNA synthesis involved in DNA repair (GO:0000731)3.07206483
79metaphase plate congression (GO:0051310)3.05666095
80regulation of mitotic spindle organization (GO:0060236)3.04391239
81regulation of hippo signaling (GO:0035330)3.03115534
82DNA strand elongation (GO:0022616)3.00821470
83regulation of NFAT protein import into nucleus (GO:0051532)3.00332887
84regulation of DNA damage checkpoint (GO:2000001)3.00195795
85DNA methylation involved in gamete generation (GO:0043046)2.99653531
86Golgi transport vesicle coating (GO:0048200)2.96097653
87COPI coating of Golgi vesicle (GO:0048205)2.96097653
88activation of Rac GTPase activity (GO:0032863)2.95693580
89histone H4-K12 acetylation (GO:0043983)2.94908954
90determination of adult lifespan (GO:0008340)2.94194841
91DNA replication checkpoint (GO:0000076)2.93549894
92negative regulation of DNA repair (GO:0045738)2.92736348
93protein localization to chromosome (GO:0034502)2.91709040
94establishment of RNA localization (GO:0051236)2.91605117
95nucleic acid transport (GO:0050657)2.91605117
96RNA transport (GO:0050658)2.91605117
97protein export from nucleus (GO:0006611)2.90793504
98regulation of sister chromatid cohesion (GO:0007063)2.89959077
99protein K6-linked ubiquitination (GO:0085020)2.89465984
100chaperone-mediated protein complex assembly (GO:0051131)2.88127343
101DNA replication-independent nucleosome assembly (GO:0006336)2.87526204
102DNA replication-independent nucleosome organization (GO:0034724)2.87526204
103kinetochore organization (GO:0051383)2.87079896
104histone H2A acetylation (GO:0043968)2.85376800
105regulation of meiosis I (GO:0060631)2.85056334
106monoubiquitinated protein deubiquitination (GO:0035520)2.83919810
107positive regulation of mitotic sister chromatid separation (GO:1901970)2.83918170
108positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.83918170
109positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.83918170
110regulation of chromosome segregation (GO:0051983)2.83693528
111DNA methylation (GO:0006306)2.82934730
112DNA alkylation (GO:0006305)2.82934730
113cytoskeletal anchoring at plasma membrane (GO:0007016)2.82910203
114negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.82516590
115proline biosynthetic process (GO:0006561)2.80898138
116chromosome condensation (GO:0030261)2.80878877
117regulation of histone H3-K27 methylation (GO:0061085)2.80766761
118chromatin silencing (GO:0006342)2.80631944
119RNA stabilization (GO:0043489)2.79828510
120mRNA stabilization (GO:0048255)2.79828510
121chromosome organization involved in meiosis (GO:0070192)2.79141110
122chromatin remodeling at centromere (GO:0031055)2.79119943
123RNA export from nucleus (GO:0006405)2.78399742
124paraxial mesoderm development (GO:0048339)2.78384091
125regulation of nucleobase-containing compound transport (GO:0032239)2.77718791
126mitochondrial DNA metabolic process (GO:0032042)2.76924067
127desmosome organization (GO:0002934)2.72036124
128positive regulation of cell cycle checkpoint (GO:1901978)2.71199565
129mitotic G1 DNA damage checkpoint (GO:0031571)2.65879057
130double-strand break repair via nonhomologous end joining (GO:0006303)2.64351614
131non-recombinational repair (GO:0000726)2.64351614
132regulation of glucose import in response to insulin stimulus (GO:2001273)2.62921762
133regulation of mammary gland epithelial cell proliferation (GO:0033599)2.62597393
134folic acid metabolic process (GO:0046655)2.58243355
135DNA topological change (GO:0006265)2.56943105
136biotin metabolic process (GO:0006768)2.56243242
137neural tube development (GO:0021915)2.56037148
138NLS-bearing protein import into nucleus (GO:0006607)2.55703399
139G1 DNA damage checkpoint (GO:0044783)2.54619073
140rRNA transcription (GO:0009303)2.53963841
141DNA packaging (GO:0006323)2.52562356
142negative regulation of fatty acid transport (GO:2000192)2.50732837
143embryonic eye morphogenesis (GO:0048048)2.50016372
144morphogenesis of an epithelial sheet (GO:0002011)2.49544819
145tRNA methylation (GO:0030488)2.48913530
146inner cell mass cell proliferation (GO:0001833)2.45293735
147insulin-like growth factor receptor signaling pathway (GO:0048009)2.43721712
148regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.42192311
149snRNA transcription (GO:0009301)2.38441161
150hippo signaling (GO:0035329)2.38108983
151positive regulation of DNA-dependent DNA replication (GO:2000105)2.35094696
152peptidyl-arginine omega-N-methylation (GO:0035247)2.35061823
153glutamine metabolic process (GO:0006541)2.34884926
154regulation of centrosome duplication (GO:0010824)2.33605980
155epithelial cell-cell adhesion (GO:0090136)2.33411205
156telomere maintenance via semi-conservative replication (GO:0032201)2.33408420
157protein-DNA complex disassembly (GO:0032986)2.33193040
158nucleosome disassembly (GO:0006337)2.33193040

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.40542846
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.57495841
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.80892933
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.70968942
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.61071910
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.55796368
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92535843
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91447871
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.78759770
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.73456666
11MYC_22102868_ChIP-Seq_BL_Human2.56552176
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.56480294
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51905197
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18477397
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15331337
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.13839159
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.10411217
18AR_21909140_ChIP-Seq_LNCAP_Human2.01735441
19MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99223042
20XRN2_22483619_ChIP-Seq_HELA_Human1.94549235
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91506414
22POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86527630
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85337569
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.82668752
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.82513163
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.77607548
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.73238976
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.73238976
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.73238976
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70592270
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69203147
32CIITA_25753668_ChIP-Seq_RAJI_Human1.67821428
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66828163
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66647506
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64818126
36PKCTHETA_26484144_Chip-Seq_BREAST_Human1.63013053
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62194224
38VDR_23849224_ChIP-Seq_CD4+_Human1.58163590
39KDM5A_27292631_Chip-Seq_BREAST_Human1.56817849
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55610894
41FOXP3_21729870_ChIP-Seq_TREG_Human1.54520382
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54332995
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.54324937
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53294133
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52988300
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52803370
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52430980
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.52361711
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51246578
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49916254
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47199838
52RACK7_27058665_Chip-Seq_MCF-7_Human1.46888784
53CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.45824543
54CLOCK_20551151_ChIP-Seq_293T_Human1.45755434
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44261841
56DCP1A_22483619_ChIP-Seq_HELA_Human1.43255764
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42449972
58* GABP_19822575_ChIP-Seq_HepG2_Human1.42447305
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40320175
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39482697
61DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.38994566
62TTF2_22483619_ChIP-Seq_HELA_Human1.38196545
63NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.38034224
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37373197
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36862001
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35422044
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32608640
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30566215
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30529579
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30528369
71GABP_17652178_ChIP-ChIP_JURKAT_Human1.29918656
72ATF3_27146783_Chip-Seq_COLON_Human1.29878789
73UBF1/2_26484160_Chip-Seq_HMECs_Human1.29339468
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28613996
75GATA1_22025678_ChIP-Seq_K562_Human1.28394047
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26645900
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25381585
78TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24529245
79TFEB_21752829_ChIP-Seq_HELA_Human1.23810960
80TP53_22127205_ChIP-Seq_IMR90_Human1.22970184
81KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22692088
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22359358
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21560146
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21298037
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21195591
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21195591
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20575577
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18196515
89NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17170166
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16840009
91VDR_21846776_ChIP-Seq_THP-1_Human1.16683532
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16041087
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15645305
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14341805
95ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11832202
96NANOG_21062744_ChIP-ChIP_HESCs_Human1.11248580
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10586773
98* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10577834
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09739811
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.09428609
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08638223
102RUNX1_27514584_Chip-Seq_MCF-7_Human1.08082695
103KDM2B_26808549_Chip-Seq_K562_Human1.05955920
104PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05893165
105FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05519664
106NCOR1_26117541_ChIP-Seq_K562_Human1.04632518
107ZNF263_19887448_ChIP-Seq_K562_Human1.04127764
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04064806
109LXR_22292898_ChIP-Seq_THP-1_Human1.03463209
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03420368
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03175100
112NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02104773
113ELK1_19687146_ChIP-ChIP_HELA_Human1.01781944
114TCF7_22412390_ChIP-Seq_EML_Mouse1.01447487
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01333382
116TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00985919
117TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00893178
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99000745
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98844545
120KDM2B_26808549_Chip-Seq_DND41_Human0.98643796
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.98437750
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97236321
123MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97185546
124UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96069663
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95677766
126ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95298470
127EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94526487
128YY1_21170310_ChIP-Seq_MESCs_Mouse0.94525891
129SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94197315
130ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94087745
131SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93601310
132CREB1_26743006_Chip-Seq_LNCaP_Human0.92905389
133CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92173311
134GATA6_25053715_ChIP-Seq_YYC3_Human0.92009907
135KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91766991
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91593619
137NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91095625
138UTX_26944678_Chip-Seq_JUKART_Human0.90259988
139KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89694701
140E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89480919
141STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87664078
142KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87638059
143MYB_26560356_Chip-Seq_TH1_Human0.86017138
144RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83901991
145HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83825856
146CHD1_26751641_Chip-Seq_LNCaP_Human0.82931068
147POU5F1_16518401_ChIP-PET_MESCs_Mouse0.82467180
148NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.81981557
149DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81414759

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.30905171
2MP0010094_abnormal_chromosome_stability4.03358164
3MP0008877_abnormal_DNA_methylation3.99609558
4MP0003111_abnormal_nucleus_morphology3.84748684
5MP0003693_abnormal_embryo_hatching3.84475631
6MP0004957_abnormal_blastocyst_morpholog3.56033315
7MP0003077_abnormal_cell_cycle3.38189813
8MP0008058_abnormal_DNA_repair2.93739324
9MP0010352_gastrointestinal_tract_polyps2.82322407
10MP0010307_abnormal_tumor_latency2.61546949
11MP0001730_embryonic_growth_arrest2.49940432
12MP0001661_extended_life_span2.42495379
13MP0008007_abnormal_cellular_replicative2.38537190
14MP0005076_abnormal_cell_differentiation2.28030114
15MP0002877_abnormal_melanocyte_morpholog2.27990412
16MP0000350_abnormal_cell_proliferation2.24323142
17MP0008438_abnormal_cutaneous_collagen2.22474506
18MP0003123_paternal_imprinting2.19341302
19MP0005380_embryogenesis_phenotype2.04064043
20MP0001672_abnormal_embryogenesis/_devel2.04064043
21MP0003941_abnormal_skin_development2.00649729
22MP0004272_abnormal_basement_membrane1.97321295
23MP0003786_premature_aging1.95095429
24MP0004197_abnormal_fetal_growth/weight/1.93562249
25MP0002396_abnormal_hematopoietic_system1.88394464
26MP0003984_embryonic_growth_retardation1.87620094
27MP0008932_abnormal_embryonic_tissue1.85072233
28MP0002088_abnormal_embryonic_growth/wei1.84519807
29MP0002084_abnormal_developmental_patter1.81384259
30MP0002210_abnormal_sex_determination1.79968351
31MP0002009_preneoplasia1.76391342
32MP0001697_abnormal_embryo_size1.76164372
33MP0002085_abnormal_embryonic_tissue1.74675593
34MP0002086_abnormal_extraembryonic_tissu1.70483347
35MP0001929_abnormal_gametogenesis1.70458718
36MP0003705_abnormal_hypodermis_morpholog1.67393783
37MP0000579_abnormal_nail_morphology1.65609303
38MP0002080_prenatal_lethality1.64044525
39MP0003890_abnormal_embryonic-extraembry1.60425249
40MP0001145_abnormal_male_reproductive1.57871476
41MP0003950_abnormal_plasma_membrane1.55954714
42MP0004808_abnormal_hematopoietic_stem1.54184266
43MP0003121_genomic_imprinting1.51946538
44MP0002653_abnormal_ependyma_morphology1.51390110
45MP0005410_abnormal_fertilization1.50609959
46MP0010030_abnormal_orbit_morphology1.49671696
47MP0005409_darkened_coat_color1.46248464
48MP0002060_abnormal_skin_morphology1.39125058
49MP0003763_abnormal_thymus_physiology1.37152631
50MP0000003_abnormal_adipose_tissue1.37050394
51MP0001293_anophthalmia1.34245979
52MP0000653_abnormal_sex_gland1.30508192
53MP0003698_abnormal_male_reproductive1.28578701
54MP0000313_abnormal_cell_death1.28516980
55MP0003091_abnormal_cell_migration1.27624622
56MP0003567_abnormal_fetal_cardiomyocyte1.24447565
57MP0009278_abnormal_bone_marrow1.23904595
58MP0000490_abnormal_crypts_of1.23309895
59MP0002019_abnormal_tumor_incidence1.23110370
60MP0004858_abnormal_nervous_system1.22539063
61MP0003566_abnormal_cell_adhesion1.22107876
62MP0001348_abnormal_lacrimal_gland1.21968623
63MP0000703_abnormal_thymus_morphology1.18247497
64MP0003453_abnormal_keratinocyte_physiol1.18126922
65MP0009672_abnormal_birth_weight1.14916082
66MP0005451_abnormal_body_composition1.13733200
67MP0003119_abnormal_digestive_system1.13519909
68MP0000762_abnormal_tongue_morphology1.12231774
69MP0000537_abnormal_urethra_morphology1.12006191
70MP0005397_hematopoietic_system_phenotyp1.11161309
71MP0001545_abnormal_hematopoietic_system1.11161309
72MP0005171_absent_coat_pigmentation1.10331479
73MP0005257_abnormal_intraocular_pressure1.09856032
74MP0000678_abnormal_parathyroid_gland1.09341543
75MP0009703_decreased_birth_body1.08893265
76MP0002796_impaired_skin_barrier1.06510945
77MP0009697_abnormal_copulation1.05658516
78MP0003787_abnormal_imprinting1.05372263
79MP0002269_muscular_atrophy1.05064467
80MP0003385_abnormal_body_wall1.04303099
81MP0004133_heterotaxia1.02254719
82MP0005275_abnormal_skin_tensile1.01347072
83MP0003942_abnormal_urinary_system1.00340469
84MP0010630_abnormal_cardiac_muscle0.99370623
85MP0002108_abnormal_muscle_morphology0.98300874
86MP0000759_abnormal_skeletal_muscle0.97929127
87MP0004233_abnormal_muscle_weight0.97095096
88MP0001915_intracranial_hemorrhage0.95984323
89MP0001849_ear_inflammation0.95276703
90MP0008995_early_reproductive_senescence0.95255851
91MP0002089_abnormal_postnatal_growth/wei0.94657184
92MP0002249_abnormal_larynx_morphology0.93763550
93MP0002398_abnormal_bone_marrow0.92996073
94MP0005501_abnormal_skin_physiology0.92595527
95MP0006138_congestive_heart_failure0.90866015
96MP0005375_adipose_tissue_phenotype0.90599413
97MP0005023_abnormal_wound_healing0.90499644
98MP0004087_abnormal_muscle_fiber0.90162539
99MP0000467_abnormal_esophagus_morphology0.90001665
100MP0000747_muscle_weakness0.89379354
101MP0002161_abnormal_fertility/fecundity0.88224570
102MP0000534_abnormal_ureter_morphology0.88160833
103MP0000733_abnormal_muscle_development0.87949745
104MP0000428_abnormal_craniofacial_morphol0.86263964
105MP0005621_abnormal_cell_physiology0.86217302
106MP0004264_abnormal_extraembryonic_tissu0.85833903
107MP0010678_abnormal_skin_adnexa0.85465789
108MP0002722_abnormal_immune_system0.84619024
109MP0002092_abnormal_eye_morphology0.84091806
110MP0010368_abnormal_lymphatic_system0.83798950
111MP0001299_abnormal_eye_distance/0.83605858
112MP0000689_abnormal_spleen_morphology0.82810766
113MP0005666_abnormal_adipose_tissue0.80862450
114MP0005384_cellular_phenotype0.80328909
115MP0002160_abnormal_reproductive_system0.80143396
116MP0002697_abnormal_eye_size0.79917285
117MP0002111_abnormal_tail_morphology0.79056629
118MP0009333_abnormal_splenocyte_physiolog0.78925045
119MP0008961_abnormal_basal_metabolism0.78874103
120MP0000383_abnormal_hair_follicle0.77741824
121MP0002114_abnormal_axial_skeleton0.77223208
122MP0002925_abnormal_cardiovascular_devel0.76631437
123MP0009053_abnormal_anal_canal0.75195550
124MP0010234_abnormal_vibrissa_follicle0.73545596
125MP0003115_abnormal_respiratory_system0.73508346
126MP0000432_abnormal_head_morphology0.73350646
127MP0004185_abnormal_adipocyte_glucose0.71741154
128MP0003806_abnormal_nucleotide_metabolis0.67797887
129MP0008770_decreased_survivor_rate0.67656989
130MP0003935_abnormal_craniofacial_develop0.66039632
131MP0001119_abnormal_female_reproductive0.65679475
132MP0000371_diluted_coat_color0.65544444
133MP0005623_abnormal_meninges_morphology0.65308878
134MP0003718_maternal_effect0.65096274
135MP0000266_abnormal_heart_morphology0.64802725
136MP0003861_abnormal_nervous_system0.64759453
137MP0000358_abnormal_cell_content/0.64685436
138MP0003937_abnormal_limbs/digits/tail_de0.64597485
139MP0003936_abnormal_reproductive_system0.61331248
140MP0005670_abnormal_white_adipose0.61046350
141MP0002429_abnormal_blood_cell0.60183178
142MP0000569_abnormal_digit_pigmentation0.59669988
143MP0003699_abnormal_female_reproductive0.57703370
144MP0000477_abnormal_intestine_morphology0.57548745
145MP0005377_hearing/vestibular/ear_phenot0.56642543

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.48774613
2Selective tooth agenesis (HP:0001592)4.01340248
3Dysmetric saccades (HP:0000641)3.46011690
4Abnormality of the astrocytes (HP:0100707)3.37819277
5Astrocytoma (HP:0009592)3.37819277
6Medulloblastoma (HP:0002885)3.26424925
7Ulnar bowing (HP:0003031)3.20529999
8Chromsome breakage (HP:0040012)3.17312104
9Missing ribs (HP:0000921)3.15397995
10Impulsivity (HP:0100710)3.12181673
11Degeneration of anterior horn cells (HP:0002398)3.02430091
12Abnormality of the anterior horn cell (HP:0006802)3.02430091
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.97385006
14Abnormality of the lower motor neuron (HP:0002366)2.96885319
15Neoplasm of the oral cavity (HP:0100649)2.95336996
1611 pairs of ribs (HP:0000878)2.93862581
17Broad face (HP:0000283)2.85064813
18Prominent nose (HP:0000448)2.83537932
19Glioma (HP:0009733)2.76078468
20Ankyloglossia (HP:0010296)2.72941980
21Abnormality of the distal phalanx of the thumb (HP:0009617)2.71078394
22Volvulus (HP:0002580)2.70495688
23Rhabdomyosarcoma (HP:0002859)2.69635937
24Abnormality of the labia minora (HP:0012880)2.66472119
25Colon cancer (HP:0003003)2.63244735
26Abnormality of chromosome stability (HP:0003220)2.62922772
27Ectopic kidney (HP:0000086)2.62248039
28Heterotopia (HP:0002282)2.61955065
29Basal cell carcinoma (HP:0002671)2.59724583
30Neoplasm of striated muscle (HP:0009728)2.54204886
31Premature rupture of membranes (HP:0001788)2.50017794
32Deviation of the thumb (HP:0009603)2.49864578
33Abnormality of the fingertips (HP:0001211)2.49648871
34Proximal placement of thumb (HP:0009623)2.48124378
35Birth length less than 3rd percentile (HP:0003561)2.46230180
36Protrusio acetabuli (HP:0003179)2.45663514
37Agnosia (HP:0010524)2.42785788
38Abnormality of oral frenula (HP:0000190)2.42583182
39Increased nuchal translucency (HP:0010880)2.41451276
40Supernumerary spleens (HP:0009799)2.39402026
41Absent thumb (HP:0009777)2.33152306
42Relative macrocephaly (HP:0004482)2.32446206
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.31248146
44Short 4th metacarpal (HP:0010044)2.30180567
45Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.30180567
46Persistence of primary teeth (HP:0006335)2.28986761
47Shallow orbits (HP:0000586)2.27215964
48High pitched voice (HP:0001620)2.26288225
49Myelodysplasia (HP:0002863)2.26011231
50Biliary tract neoplasm (HP:0100574)2.24913579
51Natal tooth (HP:0000695)2.24890616
52Meckel diverticulum (HP:0002245)2.24674388
53Sandal gap (HP:0001852)2.20313943
54Reticulocytopenia (HP:0001896)2.20098048
55Cafe-au-lait spot (HP:0000957)2.16511693
56Trismus (HP:0000211)2.15161208
57Abnormal number of incisors (HP:0011064)2.14832393
58Abnormality of the ileum (HP:0001549)2.14306906
59Facial hemangioma (HP:0000329)2.13139484
60Abdominal situs inversus (HP:0003363)2.13067074
61Abnormality of abdominal situs (HP:0011620)2.13067074
62Short humerus (HP:0005792)2.09929711
63Advanced eruption of teeth (HP:0006288)2.09264224
64Aplasia/hypoplasia of the humerus (HP:0006507)2.08729133
65Short nail (HP:0001799)2.07397858
66Long eyelashes (HP:0000527)2.07048247
67Sloping forehead (HP:0000340)2.06377930
68Atrophic scars (HP:0001075)2.05351200
69Distal lower limb amyotrophy (HP:0008944)2.05344879
70Septate vagina (HP:0001153)2.05318590
71Progressive muscle weakness (HP:0003323)2.04879273
72Amaurosis fugax (HP:0100576)2.03270282
73Spinal muscular atrophy (HP:0007269)2.03073279
74Abnormality of the preputium (HP:0100587)2.03040542
75Disproportionate tall stature (HP:0001519)2.02829583
76Flat acetabular roof (HP:0003180)2.01443202
77Dislocated radial head (HP:0003083)2.01265206
78Patellar aplasia (HP:0006443)2.00818373
79Osteolytic defects of the hand bones (HP:0009699)2.00590705
80Osteolytic defects of the phalanges of the hand (HP:0009771)2.00590705
81Absent radius (HP:0003974)2.00037954
82Hand muscle atrophy (HP:0009130)1.99562129
83Pelvic girdle muscle weakness (HP:0003749)1.99046991
84Duodenal stenosis (HP:0100867)1.98041615
85Small intestinal stenosis (HP:0012848)1.98041615
86Abnormality of the phalanges of the hallux (HP:0010057)1.98038289
87Sparse lateral eyebrow (HP:0005338)1.97074901
88Abnormality of the carotid arteries (HP:0005344)1.96771861
89Deep philtrum (HP:0002002)1.96567616
90Metaphyseal cupping (HP:0003021)1.95268108
91Cerebral aneurysm (HP:0004944)1.94776182
92Malignant gastrointestinal tract tumors (HP:0006749)1.93757270
93Gastrointestinal carcinoma (HP:0002672)1.93757270
94Increased connective tissue (HP:0009025)1.93286105
95Breast hypoplasia (HP:0003187)1.92222946
96Upper motor neuron abnormality (HP:0002127)1.91616358
97Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.89751489
98Fragile skin (HP:0001030)1.89599619
99Neoplasm of the pancreas (HP:0002894)1.89586391
100Rib fusion (HP:0000902)1.88928340
101Hyperacusis (HP:0010780)1.88881292
102Insomnia (HP:0100785)1.88851034
103Renovascular hypertension (HP:0100817)1.88295574
104Squamous cell carcinoma (HP:0002860)1.86957529
105Anal stenosis (HP:0002025)1.86762553
106Truncal obesity (HP:0001956)1.86463928
107Urethral obstruction (HP:0000796)1.85599600
108Vertebral arch anomaly (HP:0008438)1.84955636
109Abnormality of the distal phalanges of the toes (HP:0010182)1.84139309
110Atrophy/Degeneration involving motor neurons (HP:0007373)1.83712308
111Nasal polyposis (HP:0100582)1.82839302
112Aplasia/Hypoplasia of the patella (HP:0006498)1.81756803
113Increased density of long bones (HP:0006392)1.81668422
114Supernumerary bones of the axial skeleton (HP:0009144)1.81584491
115Aplasia involving forearm bones (HP:0009822)1.81501639
116Absent forearm bone (HP:0003953)1.81501639
117Skin tags (HP:0010609)1.81150954
118Skull defect (HP:0001362)1.81113249
119Abnormal spermatogenesis (HP:0008669)1.80453105
120Elbow flexion contracture (HP:0002987)1.80306444
121Patellar dislocation (HP:0002999)1.79902381
122Wormian bones (HP:0002645)1.79900961
123Abnormality of the radial head (HP:0003995)1.79653551
124Self-mutilation (HP:0000742)1.77932446
125Mitral valve prolapse (HP:0001634)1.76446048
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.74246270
127Bladder diverticulum (HP:0000015)1.74108598
128Carpal bone hypoplasia (HP:0001498)1.73972910
129Abnormal ossification of hand bones (HP:0005921)1.73960869
130Absent frontal sinuses (HP:0002688)1.73451324
131Atresia of the external auditory canal (HP:0000413)1.73189166
132Abnormality of the calcaneus (HP:0008364)1.73115848
133Short thumb (HP:0009778)1.71842042
134Elfin facies (HP:0004428)1.71701699
135Smooth philtrum (HP:0000319)1.71295412
136Amyotrophic lateral sclerosis (HP:0007354)1.71002755
137Hypopigmentation of the fundus (HP:0007894)1.70931174
138Underdeveloped nasal alae (HP:0000430)1.70907689
139Broad palm (HP:0001169)1.70743562
140Asymmetry of the thorax (HP:0001555)1.70696535
141Premature ovarian failure (HP:0008209)1.70614329
142Pseudobulbar signs (HP:0002200)1.70450097
143Overlapping toe (HP:0001845)1.70330127
144Flat cornea (HP:0007720)1.69682060
145Tracheoesophageal fistula (HP:0002575)1.69248770
146Abnormality of DNA repair (HP:0003254)1.69205291
147Supernumerary ribs (HP:0005815)1.68805770
148Milia (HP:0001056)1.68116964
149High anterior hairline (HP:0009890)1.67999615
150Narrow palate (HP:0000189)1.67740136
151Abnormality of the salivary glands (HP:0010286)1.66532185
152Ureteral duplication (HP:0000073)1.66528415
153Premature skin wrinkling (HP:0100678)1.64530586
154Overriding aorta (HP:0002623)1.64448676
155Duplicated collecting system (HP:0000081)1.64324416
156Syringomyelia (HP:0003396)1.63810215
157Spinal cord lesions (HP:0100561)1.63810215
158Acute myeloid leukemia (HP:0004808)1.62080092
159Macroorchidism (HP:0000053)1.61774526
160Limited elbow extension (HP:0001377)1.59976466
161Obsessive-compulsive behavior (HP:0000722)1.59728164
162Spinal rigidity (HP:0003306)1.58242221
163Pointed chin (HP:0000307)1.58020635
164Lip pit (HP:0100267)1.56764491
165Renal duplication (HP:0000075)1.55242537
166Microvesicular hepatic steatosis (HP:0001414)1.54369870
167Duplication of thumb phalanx (HP:0009942)1.54192931
168Achilles tendon contracture (HP:0001771)1.53997718
169Aortic aneurysm (HP:0004942)1.53694083
170Intestinal malrotation (HP:0002566)1.53673273
171Bronchomalacia (HP:0002780)1.53668513
172Abnormality of carpal bone ossification (HP:0006257)1.53264434
173Nasolacrimal duct obstruction (HP:0000579)1.52151818
174Bowel incontinence (HP:0002607)1.50071136
175Bowing of the arm (HP:0006488)1.49346477
176Bowed forearm bones (HP:0003956)1.49346477
177Lower limb amyotrophy (HP:0007210)1.48006811
178Joint laxity (HP:0001388)1.47647506
179Short chin (HP:0000331)1.46208354

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.99819491
2CDC73.99877040
3SMG13.50698303
4NEK23.25669913
5EEF2K2.84619969
6WEE12.76062012
7NEK12.52823729
8MST1R2.25427308
9TTK2.24766132
10BUB12.22263831
11PDK32.14472288
12PDK42.14472288
13TSSK62.08652783
14BRD42.02122361
15PASK1.98633588
16EPHA21.95730037
17MAP3K101.93808426
18RPS6KB21.88890482
19ICK1.87112326
20PNCK1.79267659
21ATR1.76225372
22CDK41.72044546
23PKN21.68107468
24CHEK11.64370272
25CDK71.60383021
26MAP4K11.56239072
27PLK11.54400341
28SRPK11.52531311
29MET1.51376699
30ALK1.45403118
31STK101.45158951
32IRAK31.44559615
33MTOR1.42001710
34PRPF4B1.38948948
35SIK11.36317231
36AURKB1.31974641
37EIF2AK11.25083350
38CHEK21.24005444
39MAP3K81.23193085
40LATS11.22849948
41SCYL21.19544158
42TRIB31.19105811
43FGFR41.17197578
44ATM1.16311163
45PDK21.11989162
46PLK41.09945197
47AKT31.09164207
48MAPK111.08365260
49PTK21.07081314
50CDK21.06652518
51RPS6KA41.05511037
52PRKD31.05172679
53CAMK1D1.04706016
54PLK31.04670458
55STK31.02480910
56TRPM71.02436768
57PBK1.01760938
58DYRK30.98723523
59PIM10.97192978
60RAF10.96920283
61ACVR1B0.96687252
62CDK60.96411862
63BRSK20.93281039
64TTN0.92884790
65PIM20.91877994
66CDK80.87616099
67STK40.87327693
68MAP3K70.85744631
69MKNK10.82303898
70FLT30.82224348
71CAMK1G0.79439156
72PAK40.78850228
73MKNK20.77925673
74TGFBR10.77512999
75JAK30.77416167
76KSR20.76599710
77CDK10.74929124
78PAK20.71966259
79CDK90.69589817
80ERN10.69576205
81NME20.69009140
82TESK10.67321195
83TLK10.66689194
84AURKA0.63905081
85RIPK10.63304147
86MELK0.62938225
87MAP2K30.62906125
88MARK20.62792995
89CSNK1D0.62600370
90PDGFRB0.60236473
91MAP3K30.59629307
92CSNK2A20.59076282
93MAP3K130.58989717
94PRKDC0.58063205
95ERBB40.57811912
96NTRK10.57570852
97LRRK20.56685096
98CLK10.56666459
99FGFR10.55293030
100NEK60.54906157
101CSNK1E0.54484019
102PRKAA10.54417486
103ZAP700.53931826
104WNK10.53775475
105CHUK0.52818070
106MAPK100.52508464
107TYRO30.52382074
108DMPK0.50446425
109PDGFRA0.49989811
110NEK90.49592857
111TESK20.49494531
112PRKAA20.49198706
113PTK60.48583890
114ZAK0.48405842
115RPS6KA50.48230381
116MAPK140.47685659
117RPS6KA20.47363220
118EIF2AK30.46916840
119MAP3K20.46392267
120RPS6KC10.44992337
121RPS6KL10.44992337
122VRK10.44594338
123LMTK20.44474564
124RPS6KB10.43907182
125NME10.42351536
126LATS20.42351229
127TAOK10.42297608
128MAPK10.41701289
129AKT20.41669579
130PRKD20.41608431
131CDC42BPA0.40034436
132GSK3B0.39843922
133RET0.39650499
134STK38L0.39246039
135BMX0.39223186
136PAK10.38211700
137STK380.37915529
138RPS6KA60.37655548
139AKT10.35155130
140FGFR30.33239135
141PRKCI0.31474478
142RPS6KA10.30953980
143GRK60.30518513

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.08911403
2DNA replication_Homo sapiens_hsa030303.77667144
3RNA transport_Homo sapiens_hsa030133.58666874
4Mismatch repair_Homo sapiens_hsa034303.57452381
5Spliceosome_Homo sapiens_hsa030403.10982024
6One carbon pool by folate_Homo sapiens_hsa006703.07564527
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.81107102
8Cell cycle_Homo sapiens_hsa041102.53734505
9Base excision repair_Homo sapiens_hsa034102.50979605
10mRNA surveillance pathway_Homo sapiens_hsa030152.44576369
11Fanconi anemia pathway_Homo sapiens_hsa034602.33728173
12Nucleotide excision repair_Homo sapiens_hsa034202.31736060
13Homologous recombination_Homo sapiens_hsa034402.23360958
14RNA polymerase_Homo sapiens_hsa030202.12255728
15Non-homologous end-joining_Homo sapiens_hsa034502.12229908
16RNA degradation_Homo sapiens_hsa030181.93049184
17Basal transcription factors_Homo sapiens_hsa030221.86900559
18ECM-receptor interaction_Homo sapiens_hsa045121.59313475
19Pyrimidine metabolism_Homo sapiens_hsa002401.57118064
20Selenocompound metabolism_Homo sapiens_hsa004501.55336522
21p53 signaling pathway_Homo sapiens_hsa041151.55168289
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50537108
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49510143
24Systemic lupus erythematosus_Homo sapiens_hsa053221.46122293
25Viral carcinogenesis_Homo sapiens_hsa052031.42151077
26Focal adhesion_Homo sapiens_hsa045101.30013988
27Ribosome_Homo sapiens_hsa030101.29974347
28Epstein-Barr virus infection_Homo sapiens_hsa051691.29152256
29Antigen processing and presentation_Homo sapiens_hsa046121.27845737
30Glioma_Homo sapiens_hsa052141.20040116
31HTLV-I infection_Homo sapiens_hsa051661.16253308
32Herpes simplex infection_Homo sapiens_hsa051681.14708572
33MicroRNAs in cancer_Homo sapiens_hsa052061.11879569
34ErbB signaling pathway_Homo sapiens_hsa040121.11314535
35Lysine degradation_Homo sapiens_hsa003101.08698883
36Small cell lung cancer_Homo sapiens_hsa052221.08084974
37mTOR signaling pathway_Homo sapiens_hsa041501.05570386
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03979381
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01981333
40Proteasome_Homo sapiens_hsa030501.01700728
41Oocyte meiosis_Homo sapiens_hsa041141.01422442
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99400396
43Central carbon metabolism in cancer_Homo sapiens_hsa052300.94730656
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94487318
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94120506
46Biosynthesis of amino acids_Homo sapiens_hsa012300.94072566
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92634479
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92004252
49N-Glycan biosynthesis_Homo sapiens_hsa005100.91698626
50Melanoma_Homo sapiens_hsa052180.91172484
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88106506
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87895733
53Chronic myeloid leukemia_Homo sapiens_hsa052200.85325000
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.84631615
55VEGF signaling pathway_Homo sapiens_hsa043700.83902243
56Notch signaling pathway_Homo sapiens_hsa043300.79464776
57Purine metabolism_Homo sapiens_hsa002300.77906314
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.77678027
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.76765514
60Acute myeloid leukemia_Homo sapiens_hsa052210.76422735
61Pentose phosphate pathway_Homo sapiens_hsa000300.74991262
62Basal cell carcinoma_Homo sapiens_hsa052170.73662484
63Colorectal cancer_Homo sapiens_hsa052100.73443852
64TGF-beta signaling pathway_Homo sapiens_hsa043500.72674922
65Renal cell carcinoma_Homo sapiens_hsa052110.72658490
66Primary immunodeficiency_Homo sapiens_hsa053400.70540073
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69381554
68Adherens junction_Homo sapiens_hsa045200.69016895
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68965995
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68707580
71Hippo signaling pathway_Homo sapiens_hsa043900.66409029
72Thyroid cancer_Homo sapiens_hsa052160.65636708
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65407652
74Choline metabolism in cancer_Homo sapiens_hsa052310.64916991
75T cell receptor signaling pathway_Homo sapiens_hsa046600.62418400
76Dilated cardiomyopathy_Homo sapiens_hsa054140.61249403
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.60071632
78Legionellosis_Homo sapiens_hsa051340.59623413
79Measles_Homo sapiens_hsa051620.58738841
80HIF-1 signaling pathway_Homo sapiens_hsa040660.58474562
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58309504
82Apoptosis_Homo sapiens_hsa042100.57482200
83Alcoholism_Homo sapiens_hsa050340.56453034
84Estrogen signaling pathway_Homo sapiens_hsa049150.55629077
85Hepatitis B_Homo sapiens_hsa051610.54563974
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53945668
87Viral myocarditis_Homo sapiens_hsa054160.53880673
88ABC transporters_Homo sapiens_hsa020100.53117204
89Prostate cancer_Homo sapiens_hsa052150.52954440
90Prolactin signaling pathway_Homo sapiens_hsa049170.52404639
91B cell receptor signaling pathway_Homo sapiens_hsa046620.51599203
92Dorso-ventral axis formation_Homo sapiens_hsa043200.50974810
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.50811072
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50768813
95Sulfur relay system_Homo sapiens_hsa041220.50128156
96Pathways in cancer_Homo sapiens_hsa052000.48631966
97Thyroid hormone synthesis_Homo sapiens_hsa049180.47790072
98Type II diabetes mellitus_Homo sapiens_hsa049300.47633515
99Influenza A_Homo sapiens_hsa051640.47426945
100Glucagon signaling pathway_Homo sapiens_hsa049220.47341869
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45307255
102Hedgehog signaling pathway_Homo sapiens_hsa043400.45001549
103Non-small cell lung cancer_Homo sapiens_hsa052230.43284326
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42146342
105Proteoglycans in cancer_Homo sapiens_hsa052050.41378445
106Vitamin B6 metabolism_Homo sapiens_hsa007500.41256197
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40814287
108AMPK signaling pathway_Homo sapiens_hsa041520.40800526
109Pancreatic cancer_Homo sapiens_hsa052120.37582004
110Endometrial cancer_Homo sapiens_hsa052130.36543548
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36452063
112Insulin resistance_Homo sapiens_hsa049310.36094897
113Carbon metabolism_Homo sapiens_hsa012000.35772977
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.35223348
115Toxoplasmosis_Homo sapiens_hsa051450.34570521
116Fatty acid biosynthesis_Homo sapiens_hsa000610.33305474
117Fructose and mannose metabolism_Homo sapiens_hsa000510.32999902
118Bladder cancer_Homo sapiens_hsa052190.28980780
119FoxO signaling pathway_Homo sapiens_hsa040680.28865886
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28714651
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28644842
122Tight junction_Homo sapiens_hsa045300.28424932
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27901375
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.27283450
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26892229
126Wnt signaling pathway_Homo sapiens_hsa043100.26692309
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.25609083
128Insulin signaling pathway_Homo sapiens_hsa049100.23872233
129Inositol phosphate metabolism_Homo sapiens_hsa005620.22267451

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