URB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.52554852
2nuclear pore organization (GO:0006999)6.42629986
3pore complex assembly (GO:0046931)4.95311839
4protein localization to kinetochore (GO:0034501)4.73652764
5DNA unwinding involved in DNA replication (GO:0006268)4.71791639
6mitotic nuclear envelope disassembly (GO:0007077)4.53003000
7DNA replication-dependent nucleosome organization (GO:0034723)4.48124783
8DNA replication-dependent nucleosome assembly (GO:0006335)4.48124783
9regulation of histone H3-K9 methylation (GO:0051570)4.37496252
10nuclear envelope disassembly (GO:0051081)4.24074590
11membrane disassembly (GO:0030397)4.24074590
12folic acid-containing compound biosynthetic process (GO:0009396)4.22730373
13protein complex localization (GO:0031503)4.21388802
14DNA replication initiation (GO:0006270)4.17298459
15protein localization to chromosome, centromeric region (GO:0071459)4.15488824
16mitotic sister chromatid cohesion (GO:0007064)4.13362784
17regulation of gene silencing by RNA (GO:0060966)4.13285025
18regulation of posttranscriptional gene silencing (GO:0060147)4.13285025
19regulation of gene silencing by miRNA (GO:0060964)4.13285025
20cellular protein complex localization (GO:0034629)4.12133581
21pre-miRNA processing (GO:0031054)4.07512382
22IMP biosynthetic process (GO:0006188)4.05926535
23heterochromatin organization (GO:0070828)4.02714055
24mitotic sister chromatid segregation (GO:0000070)3.98937956
25sister chromatid segregation (GO:0000819)3.91787365
26DNA duplex unwinding (GO:0032508)3.91731875
27DNA geometric change (GO:0032392)3.91117896
28mitotic chromosome condensation (GO:0007076)3.87477824
29nucleobase biosynthetic process (GO:0046112)3.79195714
30regulation of translational fidelity (GO:0006450)3.72926425
31DNA strand elongation involved in DNA replication (GO:0006271)3.71237241
32establishment of integrated proviral latency (GO:0075713)3.70831388
33negative regulation of histone methylation (GO:0031061)3.67368536
34regulation of centriole replication (GO:0046599)3.61563474
35DNA topological change (GO:0006265)3.59588339
36IMP metabolic process (GO:0046040)3.58553903
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.55513427
38chromatin assembly (GO:0031497)3.52961774
39DNA strand elongation (GO:0022616)3.52199741
40somatic hypermutation of immunoglobulin genes (GO:0016446)3.50426443
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.50426443
42mitotic metaphase plate congression (GO:0007080)3.46497686
43regulation of RNA export from nucleus (GO:0046831)3.44755587
44positive regulation of chromosome segregation (GO:0051984)3.44243817
45double-strand break repair via nonhomologous end joining (GO:0006303)3.44058742
46non-recombinational repair (GO:0000726)3.44058742
47regulation of translational termination (GO:0006449)3.40760020
48kinetochore organization (GO:0051383)3.39625281
49gene silencing by RNA (GO:0031047)3.37603875
50protein K6-linked ubiquitination (GO:0085020)3.36614656
51translesion synthesis (GO:0019985)3.35660216
52regulation of spindle organization (GO:0090224)3.34149167
53regulation of helicase activity (GO:0051095)3.34111263
54regulation of centrosome cycle (GO:0046605)3.33578695
55meiotic chromosome segregation (GO:0045132)3.31747510
56DNA synthesis involved in DNA repair (GO:0000731)3.28156247
57DNA conformation change (GO:0071103)3.27432939
58nuclear envelope organization (GO:0006998)3.27339010
59purine nucleobase biosynthetic process (GO:0009113)3.25945594
60positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.25108002
61positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.25108002
62positive regulation of mitotic sister chromatid separation (GO:1901970)3.25108002
63folic acid metabolic process (GO:0046655)3.24678534
64formation of translation preinitiation complex (GO:0001731)3.24670412
65attachment of spindle microtubules to kinetochore (GO:0008608)3.23868998
66regulation of DNA endoreduplication (GO:0032875)3.22795144
67dosage compensation (GO:0007549)3.22744152
68metaphase plate congression (GO:0051310)3.22361111
69piRNA metabolic process (GO:0034587)3.20718258
70negative regulation of mRNA processing (GO:0050686)3.20252198
71telomere maintenance via telomere lengthening (GO:0010833)3.18973931
72ribosome assembly (GO:0042255)3.17051434
73chromatin assembly or disassembly (GO:0006333)3.15605717
74DNA replication checkpoint (GO:0000076)3.15065900
75monoubiquitinated protein deubiquitination (GO:0035520)3.14657394
76telomere maintenance via semi-conservative replication (GO:0032201)3.14065456
77chromatin remodeling at centromere (GO:0031055)3.12550671
78negative regulation of mRNA metabolic process (GO:1903312)3.10188318
79protein localization to chromosome (GO:0034502)3.09814812
80negative regulation of mitotic sister chromatid separation (GO:2000816)3.09454448
81negative regulation of sister chromatid segregation (GO:0033046)3.09454448
82negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09454448
83negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.09454448
84negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09454448
85regulation of mitotic spindle organization (GO:0060236)3.09292557
86histone H2A monoubiquitination (GO:0035518)3.09076952
87regulation of sister chromatid cohesion (GO:0007063)3.07231795
88mRNA transport (GO:0051028)3.07104530
89nucleotide-excision repair, DNA gap filling (GO:0006297)3.07041032
90regulation of gene silencing (GO:0060968)3.06854678
91regulation of chromosome segregation (GO:0051983)3.06761691
92ribonucleoprotein complex biogenesis (GO:0022613)3.06552140
93chaperone-mediated protein complex assembly (GO:0051131)3.06355561
94spliceosomal tri-snRNP complex assembly (GO:0000244)3.05903786
95determination of adult lifespan (GO:0008340)3.05755611
96maturation of SSU-rRNA (GO:0030490)3.03976977
97proline biosynthetic process (GO:0006561)3.03304363
98tRNA methylation (GO:0030488)3.02566083
99peptidyl-arginine omega-N-methylation (GO:0035247)3.02420061
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01282369
101synaptonemal complex assembly (GO:0007130)3.00858386
102negative regulation of DNA repair (GO:0045738)2.99508499
103DNA replication-independent nucleosome organization (GO:0034724)2.99477664
104DNA replication-independent nucleosome assembly (GO:0006336)2.99477664
105ribosome biogenesis (GO:0042254)2.98594179
106regulation of DNA damage checkpoint (GO:2000001)2.97658735
107rRNA transcription (GO:0009303)2.97362700
108mitotic spindle checkpoint (GO:0071174)2.96422156
109mitochondrial RNA metabolic process (GO:0000959)2.96063242
110mitotic recombination (GO:0006312)2.95495941
111tRNA aminoacylation for protein translation (GO:0006418)2.95457761
112histone exchange (GO:0043486)2.95085901
113chromosome condensation (GO:0030261)2.93537516
114amino acid activation (GO:0043038)2.93401109
115tRNA aminoacylation (GO:0043039)2.93401109
116spindle assembly involved in mitosis (GO:0090307)2.93287676
117postreplication repair (GO:0006301)2.92726031
118regulation of centrosome duplication (GO:0010824)2.91875878
119regulation of mitotic sister chromatid separation (GO:0010965)2.90908016
120regulation of mitotic sister chromatid segregation (GO:0033047)2.90908016
121regulation of sister chromatid segregation (GO:0033045)2.90908016
122mitotic spindle assembly checkpoint (GO:0007094)2.90708761
123viral mRNA export from host cell nucleus (GO:0046784)2.89313952
124negative regulation of chromosome segregation (GO:0051985)2.88975017
125telomere maintenance via recombination (GO:0000722)2.88225368
126gene silencing (GO:0016458)2.88166218
127regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.87979305
128telomere maintenance (GO:0000723)2.86496256
129regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.86412251
130negative regulation of RNA splicing (GO:0033119)2.85878669
131CENP-A containing nucleosome assembly (GO:0034080)2.85729401
132spindle assembly checkpoint (GO:0071173)2.85718298
133negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.84637459
134DNA packaging (GO:0006323)2.84005951
135establishment of chromosome localization (GO:0051303)2.82844477
136spindle checkpoint (GO:0031577)2.81989576
137regulation of mitotic metaphase/anaphase transition (GO:0030071)2.81780084

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.91003358
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.04355775
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.05741416
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.80059650
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.44021895
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.23161174
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88306827
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81920067
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.76181119
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.62962679
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57555593
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.38433737
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.28241423
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.18866318
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18735101
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18523693
17AR_21909140_ChIP-Seq_LNCAP_Human2.10679090
18MYC_22102868_ChIP-Seq_BL_Human2.07835881
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04661099
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.00727710
21MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96168396
22XRN2_22483619_ChIP-Seq_HELA_Human1.90484789
23POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80248021
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.78001195
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.76838887
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.76838887
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.76838887
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75466600
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.72206510
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71887691
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.70020138
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.64780271
33VDR_23849224_ChIP-Seq_CD4+_Human1.61635405
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51427046
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47236247
36SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47174506
37* FOXP3_21729870_ChIP-Seq_TREG_Human1.47025165
38KDM5A_27292631_Chip-Seq_BREAST_Human1.43197292
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41603477
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40450996
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40291384
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40083530
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39894631
44* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38526944
45CIITA_25753668_ChIP-Seq_RAJI_Human1.38488236
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38123202
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37149264
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35673995
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35252123
50NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.35039486
51TTF2_22483619_ChIP-Seq_HELA_Human1.33129910
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30562387
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.30480843
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30247020
55DCP1A_22483619_ChIP-Seq_HELA_Human1.29993919
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.29508733
57CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27239218
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27197298
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26822434
60GABP_19822575_ChIP-Seq_HepG2_Human1.25786058
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25562585
62* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24742386
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24177074
64ELK1_19687146_ChIP-ChIP_HELA_Human1.22272440
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20435109
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20375105
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19216042
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17944183
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16253916
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16177504
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15284886
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15170976
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13024571
74TCF3_18692474_ChIP-Seq_MESCs_Mouse1.11273518
75NANOG_21062744_ChIP-ChIP_HESCs_Human1.11138953
76TFEB_21752829_ChIP-Seq_HELA_Human1.11024142
77SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10848725
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10036194
79CHD1_26751641_Chip-Seq_LNCaP_Human1.09941664
80ZNF263_19887448_ChIP-Seq_K562_Human1.09765241
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09764238
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08715089
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07823193
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07198908
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04754864
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01646804
87* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00397684
88VDR_21846776_ChIP-Seq_THP-1_Human0.95577602
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95412431
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94971066
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94674420
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94598431
93SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94105028
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93786044
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91592547
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91001117
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89607236
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88244957
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87796410
100SOX2_18692474_ChIP-Seq_MESCs_Mouse0.87106362
101NOTCH1_21737748_ChIP-Seq_TLL_Human0.86845447
102* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86531723
103NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86374807
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86091565
105ELF1_17652178_ChIP-ChIP_JURKAT_Human0.85846381
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85660249
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.85567133
108SOX17_20123909_ChIP-Seq_XEN_Mouse0.85176623
109YY1_21170310_ChIP-Seq_MESCs_Mouse0.84390886
110MYC_18940864_ChIP-ChIP_HL60_Human0.84233514
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83889597
112PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83003913
113NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.82862651
114TCF7_22412390_ChIP-Seq_EML_Mouse0.81831283
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81828874
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81114000
117TP63_17297297_ChIP-ChIP_HaCaT_Human0.79846306
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79757424
119TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78483606
120NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.78204497
121POU5F1_16518401_ChIP-PET_MESCs_Mouse0.77981105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.51673928
2MP0008057_abnormal_DNA_replication4.39691847
3MP0003111_abnormal_nucleus_morphology4.03602937
4MP0003693_abnormal_embryo_hatching3.95267088
5MP0004957_abnormal_blastocyst_morpholog3.61111450
6MP0003077_abnormal_cell_cycle3.58441403
7MP0010352_gastrointestinal_tract_polyps3.28802956
8MP0008877_abnormal_DNA_methylation3.15935254
9MP0008058_abnormal_DNA_repair2.85276919
10MP0010307_abnormal_tumor_latency2.58840293
11MP0001730_embryonic_growth_arrest2.54831919
12MP0008007_abnormal_cellular_replicative2.52630581
13MP0000350_abnormal_cell_proliferation2.36205027
14MP0003705_abnormal_hypodermis_morpholog2.28587979
15MP0003123_paternal_imprinting2.16520109
16MP0005076_abnormal_cell_differentiation2.14422748
17MP0002396_abnormal_hematopoietic_system2.08866285
18MP0005380_embryogenesis_phenotype2.05803661
19MP0001672_abnormal_embryogenesis/_devel2.05803661
20MP0004197_abnormal_fetal_growth/weight/1.96942961
21MP0008932_abnormal_embryonic_tissue1.92016797
22MP0003984_embryonic_growth_retardation1.89321740
23MP0002084_abnormal_developmental_patter1.88452565
24MP0002088_abnormal_embryonic_growth/wei1.85971387
25MP0003786_premature_aging1.85618881
26MP0001697_abnormal_embryo_size1.84587129
27MP0002086_abnormal_extraembryonic_tissu1.82829503
28MP0009697_abnormal_copulation1.81473235
29MP0004185_abnormal_adipocyte_glucose1.81230998
30MP0002009_preneoplasia1.80756809
31MP0002085_abnormal_embryonic_tissue1.75803350
32MP0001661_extended_life_span1.73856631
33MP0001346_abnormal_lacrimal_gland1.71769710
34MP0004808_abnormal_hematopoietic_stem1.63664598
35MP0002080_prenatal_lethality1.63605632
36MP0003890_abnormal_embryonic-extraembry1.58985844
37MP0002210_abnormal_sex_determination1.54740569
38MP0005451_abnormal_body_composition1.53223640
39MP0003121_genomic_imprinting1.52659574
40MP0001929_abnormal_gametogenesis1.47704875
41MP0000490_abnormal_crypts_of1.45927985
42MP0003567_abnormal_fetal_cardiomyocyte1.44551633
43MP0003566_abnormal_cell_adhesion1.42967976
44MP0001293_anophthalmia1.40623656
45MP0001145_abnormal_male_reproductive1.38101969
46MP0000313_abnormal_cell_death1.33154774
47MP0005410_abnormal_fertilization1.28545876
48MP0002019_abnormal_tumor_incidence1.28022158
49MP0000537_abnormal_urethra_morphology1.25076774
50MP0001849_ear_inflammation1.24183265
51MP0009278_abnormal_bone_marrow1.17566076
52MP0000569_abnormal_digit_pigmentation1.16090489
53MP0005397_hematopoietic_system_phenotyp1.12869469
54MP0001545_abnormal_hematopoietic_system1.12869469
55MP0009053_abnormal_anal_canal1.11737687
56MP0000653_abnormal_sex_gland1.11695928
57MP0003315_abnormal_perineum_morphology1.08757474
58MP0004264_abnormal_extraembryonic_tissu1.08538078
59MP0003698_abnormal_male_reproductive1.06962159
60MP0005023_abnormal_wound_healing1.06954629
61MP0002653_abnormal_ependyma_morphology1.01714433
62MP0000703_abnormal_thymus_morphology1.00900898
63MP0006035_abnormal_mitochondrial_morpho1.00841443
64MP0002877_abnormal_melanocyte_morpholog0.99522338
65MP0009703_decreased_birth_body0.96805845
66MP0003119_abnormal_digestive_system0.96218690
67MP0005501_abnormal_skin_physiology0.95738440
68MP0009672_abnormal_birth_weight0.92914135
69MP0000579_abnormal_nail_morphology0.89259660
70MP0010234_abnormal_vibrissa_follicle0.89017967
71MP0001915_intracranial_hemorrhage0.88885509
72MP0002796_impaired_skin_barrier0.88081378
73MP0003937_abnormal_limbs/digits/tail_de0.87202089
74MP0010030_abnormal_orbit_morphology0.86239831
75MP0002092_abnormal_eye_morphology0.85925970
76MP0003806_abnormal_nucleotide_metabolis0.85424835
77MP0002398_abnormal_bone_marrow0.84772026
78MP0002925_abnormal_cardiovascular_devel0.84384933
79MP0002006_tumorigenesis0.84243887
80MP0003763_abnormal_thymus_physiology0.83673735
81MP0005621_abnormal_cell_physiology0.83592805
82MP0005384_cellular_phenotype0.83002459
83MP0005187_abnormal_penis_morphology0.82153640
84MP0005623_abnormal_meninges_morphology0.81560367
85MP0002697_abnormal_eye_size0.81057315
86MP0004133_heterotaxia0.81017327
87MP0002722_abnormal_immune_system0.79517122
88MP0002111_abnormal_tail_morphology0.78634897
89MP0004233_abnormal_muscle_weight0.78630154
90MP0003941_abnormal_skin_development0.76715686
91MP0002161_abnormal_fertility/fecundity0.76519838
92MP0000358_abnormal_cell_content/0.75464462
93MP0000733_abnormal_muscle_development0.75383708
94MP0000428_abnormal_craniofacial_morphol0.75069877
95MP0000432_abnormal_head_morphology0.74125180
96MP0000689_abnormal_spleen_morphology0.73427013
97MP0003950_abnormal_plasma_membrane0.72974697
98MP0003943_abnormal_hepatobiliary_system0.71308916
99MP0000762_abnormal_tongue_morphology0.70754120
100MP0008770_decreased_survivor_rate0.70747397
101MP0000371_diluted_coat_color0.70205334
102MP0002060_abnormal_skin_morphology0.70022831
103MP0000003_abnormal_adipose_tissue0.69894385
104MP0001216_abnormal_epidermal_layer0.69272401
105MP0000477_abnormal_intestine_morphology0.68991145
106MP0002166_altered_tumor_susceptibility0.68980603
107MP0000858_altered_metastatic_potential0.67332838
108MP0002160_abnormal_reproductive_system0.66960961
109MP0001286_abnormal_eye_development0.65882646
110MP0003453_abnormal_keratinocyte_physiol0.65649467
111MP0003115_abnormal_respiratory_system0.65094583
112MP0002075_abnormal_coat/hair_pigmentati0.65087696
113MP0003935_abnormal_craniofacial_develop0.64301054
114MP0008995_early_reproductive_senescence0.63503324
115MP0000627_abnormal_mammary_gland0.63361797
116MP0003385_abnormal_body_wall0.62913707
117MP0002114_abnormal_axial_skeleton0.62649912
118MP0002098_abnormal_vibrissa_morphology0.61717197
119MP0003718_maternal_effect0.61581806
120MP0001119_abnormal_female_reproductive0.61453402
121MP0003861_abnormal_nervous_system0.61391042
122MP0009333_abnormal_splenocyte_physiolog0.61062889
123MP0000266_abnormal_heart_morphology0.59666575
124MP0003221_abnormal_cardiomyocyte_apopto0.59049761
125MP0003942_abnormal_urinary_system0.58341509
126MP0002429_abnormal_blood_cell0.57288323
127MP0010630_abnormal_cardiac_muscle0.56396009
128MP0002233_abnormal_nose_morphology0.56105116
129MP0002249_abnormal_larynx_morphology0.55482356

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.36737560
2Chromsome breakage (HP:0040012)3.91125333
3Microvesicular hepatic steatosis (HP:0001414)3.86547653
4Selective tooth agenesis (HP:0001592)3.86027787
5Medulloblastoma (HP:0002885)3.55019938
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.54652386
7Progressive muscle weakness (HP:0003323)3.53122651
8Astrocytoma (HP:0009592)3.32269662
9Abnormality of the astrocytes (HP:0100707)3.32269662
10Abnormality of chromosome stability (HP:0003220)3.29326072
11Abnormality of the labia minora (HP:0012880)3.18826592
12Rhabdomyosarcoma (HP:0002859)3.10958882
13Progressive external ophthalmoplegia (HP:0000590)3.04724460
14Impulsivity (HP:0100710)3.03262647
15Agnosia (HP:0010524)3.01750035
16Deviation of the thumb (HP:0009603)2.98579353
17Birth length less than 3rd percentile (HP:0003561)2.98064938
18Septate vagina (HP:0001153)2.89559638
19Meckel diverticulum (HP:0002245)2.89429968
20Proximal placement of thumb (HP:0009623)2.88939857
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.86162440
22Volvulus (HP:0002580)2.86089392
23Abnormality of the anterior horn cell (HP:0006802)2.83786314
24Degeneration of anterior horn cells (HP:0002398)2.83786314
25Neoplasm of the oral cavity (HP:0100649)2.81483432
2611 pairs of ribs (HP:0000878)2.79494697
27Missing ribs (HP:0000921)2.78660253
28Glioma (HP:0009733)2.78606810
29Abnormality of the ileum (HP:0001549)2.78444964
30Abnormality of the preputium (HP:0100587)2.77105612
31Colon cancer (HP:0003003)2.73829222
32Ectopic kidney (HP:0000086)2.69937144
33Basal cell carcinoma (HP:0002671)2.69050934
34Increased nuchal translucency (HP:0010880)2.68638088
35Abnormality of the lower motor neuron (HP:0002366)2.62011073
36Multiple enchondromatosis (HP:0005701)2.61086587
37Reticulocytopenia (HP:0001896)2.58580116
38Biliary tract neoplasm (HP:0100574)2.57724705
39Absent thumb (HP:0009777)2.56545183
40Myelodysplasia (HP:0002863)2.55988499
41Neoplasm of striated muscle (HP:0009728)2.54726605
42Trismus (HP:0000211)2.54186644
43Prominent nose (HP:0000448)2.48780953
44Duodenal stenosis (HP:0100867)2.47613093
45Small intestinal stenosis (HP:0012848)2.47613093
46Absent radius (HP:0003974)2.46297728
47Ragged-red muscle fibers (HP:0003200)2.43140202
48Aplasia/hypoplasia of the humerus (HP:0006507)2.36356938
49Abnormality of the umbilical cord (HP:0010881)2.33200055
50Supernumerary spleens (HP:0009799)2.33166772
51Short humerus (HP:0005792)2.32914227
52Hyperacusis (HP:0010780)2.32368139
53Amaurosis fugax (HP:0100576)2.32129686
54Abnormality of the carotid arteries (HP:0005344)2.30155818
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29788757
56Sloping forehead (HP:0000340)2.28425580
57Heterotopia (HP:0002282)2.28413234
58Cafe-au-lait spot (HP:0000957)2.27737376
59Patellar aplasia (HP:0006443)2.27661867
60Abnormal umbilical cord blood vessels (HP:0011403)2.26627200
61Single umbilical artery (HP:0001195)2.26627200
62Abnormality of the fetal cardiovascular system (HP:0010948)2.26627200
63Absent forearm bone (HP:0003953)2.25820745
64Aplasia involving forearm bones (HP:0009822)2.25820745
65Choanal atresia (HP:0000453)2.24485391
66Short 4th metacarpal (HP:0010044)2.22317971
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.22317971
68Facial hemangioma (HP:0000329)2.21791266
69Short middle phalanx of the 5th finger (HP:0004220)2.21688327
70Abnormal number of incisors (HP:0011064)2.18550893
71Breast hypoplasia (HP:0003187)2.17933814
72High anterior hairline (HP:0009890)2.15084499
73Sandal gap (HP:0001852)2.14301944
74Gastrointestinal carcinoma (HP:0002672)2.10621976
75Malignant gastrointestinal tract tumors (HP:0006749)2.10621976
76High pitched voice (HP:0001620)2.09785423
77Abnormality of the duodenum (HP:0002246)2.08811804
78Abnormality of cochlea (HP:0000375)2.08510816
79Cutaneous melanoma (HP:0012056)2.06761106
80Aplasia/Hypoplasia of the patella (HP:0006498)2.05492590
81Abnormality of abdominal situs (HP:0011620)2.03391947
82Abdominal situs inversus (HP:0003363)2.03391947
83Abnormality of glycolysis (HP:0004366)2.02945992
84Neoplasm of the pancreas (HP:0002894)2.00037022
85Squamous cell carcinoma (HP:0002860)1.99862060
86Abnormality of the distal phalanx of the thumb (HP:0009617)1.96985357
87Esophageal atresia (HP:0002032)1.96374643
88Premature ovarian failure (HP:0008209)1.95296360
89Long eyelashes (HP:0000527)1.95007793
90Tracheoesophageal fistula (HP:0002575)1.91006524
91Duplication of thumb phalanx (HP:0009942)1.90902803
92Supernumerary ribs (HP:0005815)1.89421575
93Oral leukoplakia (HP:0002745)1.89366162
94Rib fusion (HP:0000902)1.88783386
95Cortical dysplasia (HP:0002539)1.88780670
96Atresia of the external auditory canal (HP:0000413)1.88430412
97Abnormality of the phalanges of the hallux (HP:0010057)1.87423132
98Nephroblastoma (Wilms tumor) (HP:0002667)1.86266945
99Supernumerary bones of the axial skeleton (HP:0009144)1.84572967
100Ureteral duplication (HP:0000073)1.84110443
101Bone marrow hypocellularity (HP:0005528)1.83805837
102Short thumb (HP:0009778)1.83065597
103Trigonocephaly (HP:0000243)1.81680119
104Insomnia (HP:0100785)1.81620896
105Carpal bone hypoplasia (HP:0001498)1.81402087
106Abnormalities of placenta or umbilical cord (HP:0001194)1.80687093
107Facial cleft (HP:0002006)1.80071393
108Overriding aorta (HP:0002623)1.78477793
109Abnormal lung lobation (HP:0002101)1.78352247
110Broad distal phalanx of finger (HP:0009836)1.76730422
111Ovarian neoplasm (HP:0100615)1.76145103
112Abnormality of DNA repair (HP:0003254)1.75861695
113Abnormality of the calcaneus (HP:0008364)1.74773654
114Aplasia/Hypoplasia of the sternum (HP:0006714)1.74602279
115Upper motor neuron abnormality (HP:0002127)1.74550620
116Preauricular skin tag (HP:0000384)1.73883552
117Skull defect (HP:0001362)1.73236869
118Abnormal biliary tract morphology (HP:0012440)1.73139423
119Duplicated collecting system (HP:0000081)1.72409429
120Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.71670363
121Overlapping toe (HP:0001845)1.71614287
122Broad palm (HP:0001169)1.71420178
123Hypopigmentation of the fundus (HP:0007894)1.71372585
124Abnormality of the distal phalanges of the toes (HP:0010182)1.71345147
125Clubbing of toes (HP:0100760)1.70354528
126Urethral obstruction (HP:0000796)1.70169371
127Aplastic anemia (HP:0001915)1.70053454
128Spastic diplegia (HP:0001264)1.69605107
129Abnormality of oral frenula (HP:0000190)1.69270603
130Embryonal renal neoplasm (HP:0011794)1.68804166
131Arteriovenous malformation (HP:0100026)1.68684837
132Ulnar bowing (HP:0003031)1.68204017
133Hypergonadotropic hypogonadism (HP:0000815)1.67678852
134Sparse lateral eyebrow (HP:0005338)1.67500498
135Deep philtrum (HP:0002002)1.65850212
136Ankyloglossia (HP:0010296)1.65778607
137Shoulder girdle muscle weakness (HP:0003547)1.65656063
138Neoplasm of the adrenal cortex (HP:0100641)1.65446877
139Spinal muscular atrophy (HP:0007269)1.65396456
140Horseshoe kidney (HP:0000085)1.65114011
141IgA deficiency (HP:0002720)1.64830485
142Atrophy/Degeneration involving motor neurons (HP:0007373)1.64146119
143Abnormality of pyrimidine metabolism (HP:0004353)1.64026289
144Neoplasm of the colon (HP:0100273)1.63781277
145Poikiloderma (HP:0001029)1.63051111
146Rough bone trabeculation (HP:0100670)1.63041551
147Abnormal foot bone ossification (HP:0010675)1.60190860
148Partial agenesis of the corpus callosum (HP:0001338)1.59112037
149Triphalangeal thumb (HP:0001199)1.58248253
150Sensory axonal neuropathy (HP:0003390)1.58027601
151Increased serum pyruvate (HP:0003542)1.57931881
152Acute myeloid leukemia (HP:0004808)1.56639619

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.42224666
2CDK124.26602851
3SMG13.24989050
4WEE13.22545543
5NEK23.13833736
6EEF2K2.81843264
7TTK2.50825289
8SRPK12.26004587
9TSSK62.24997018
10BUB12.22576136
11PDK32.20940925
12PDK42.20940925
13EPHA22.19971964
14PBK2.06700978
15NEK12.05807879
16RPS6KB22.01491998
17PASK1.95578126
18BRD41.93062805
19ATR1.86863311
20MAP3K101.85036450
21NME21.80115087
22PLK11.75846441
23CDK71.70893590
24EIF2AK11.64035086
25TAF11.58086270
26CHEK11.55338704
27PKN21.53207082
28CDK41.53018752
29CHEK21.50963977
30IRAK31.48304634
31AURKB1.47115985
32STK101.46282424
33BRSK21.41978414
34ALK1.40427025
35SCYL21.39164239
36STK31.36057312
37VRK21.35432543
38ACVR1B1.33995535
39CDK81.32778162
40MKNK11.32660560
41MAP3K81.27026832
42PLK31.26837121
43MKNK21.26160429
44ZAK1.25845896
45TLK11.24969430
46ATM1.23498062
47TGFBR11.21479053
48PDK21.20203155
49CAMK1G1.20016410
50PRPF4B1.18826463
51FLT31.18683108
52PNCK1.18446566
53ICK1.14844584
54CDK61.12289618
55LATS11.10886928
56MTOR1.09885518
57STK41.09444876
58PIM11.05182124
59PLK41.03595573
60PAK41.02199365
61CAMK1D1.01996497
62CDK21.01973100
63MST1R0.97282958
64DYRK30.87450208
65TESK10.85485208
66RPS6KA40.80060114
67EIF2AK30.79784967
68EIF2AK20.78004670
69AURKA0.77527663
70TYRO30.75262603
71FGFR10.74662603
72CDK10.72956954
73MELK0.72019316
74PDGFRA0.71661096
75TTN0.70377933
76ERBB40.69637649
77MAP3K90.69580707
78MAPK110.69047911
79VRK10.67992004
80TESK20.67040706
81PAK20.66290098
82NME10.64749563
83CSNK1D0.63921375
84CSNK2A20.60692918
85BRSK10.59016766
86CDK90.58816840
87MET0.58251759
88TRIM280.55734730
89STK160.54231531
90MAP4K10.54178930
91NEK90.51329850
92PIM20.50493526
93PRKDC0.50078643
94CSNK1E0.49720004
95TRIB30.48315053
96STK38L0.46880093
97MST40.46091981
98TAOK20.45322419
99BMX0.44844442
100AKT20.44842247
101MAPK140.42226503
102RAF10.42161788
103RPS6KB10.41710041
104LRRK20.40441442
105CLK10.39385909
106RPS6KA10.38835157
107RPS6KA50.38570744
108CSNK2A10.37845612
109PAK10.37101467
110FGFR30.36990642
111KDR0.35938059
112MAPK10.34930203
113PTK60.34219734
114PRKCI0.33253203
115FGFR20.32791382
116GRK60.32434756
117JAK30.32210300
118GSK3B0.31929238
119MARK30.31902284
120AKT30.31507381
121AKT10.31304942
122NUAK10.30951081
123FGFR40.30756465
124LATS20.29886328
125PDGFRB0.28258539
126RIPK10.28257608
127MAP3K140.27730241

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.20882713
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.94011259
3Mismatch repair_Homo sapiens_hsa034303.91883199
4RNA transport_Homo sapiens_hsa030133.42668062
5One carbon pool by folate_Homo sapiens_hsa006703.15537181
6Spliceosome_Homo sapiens_hsa030402.97851329
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.83064074
8Cell cycle_Homo sapiens_hsa041102.78675764
9Fanconi anemia pathway_Homo sapiens_hsa034602.64041447
10Homologous recombination_Homo sapiens_hsa034402.59049079
11Non-homologous end-joining_Homo sapiens_hsa034502.52728336
12Nucleotide excision repair_Homo sapiens_hsa034202.50102658
13Base excision repair_Homo sapiens_hsa034102.44675691
14mRNA surveillance pathway_Homo sapiens_hsa030152.33227031
15Systemic lupus erythematosus_Homo sapiens_hsa053222.14678624
16RNA polymerase_Homo sapiens_hsa030201.89995343
17RNA degradation_Homo sapiens_hsa030181.81533630
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60384295
19p53 signaling pathway_Homo sapiens_hsa041151.60334493
20Basal transcription factors_Homo sapiens_hsa030221.58461775
21Pyrimidine metabolism_Homo sapiens_hsa002401.53970449
22Viral carcinogenesis_Homo sapiens_hsa052031.52194383
23Ribosome_Homo sapiens_hsa030101.48382589
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.47701219
25Selenocompound metabolism_Homo sapiens_hsa004501.28244653
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26970648
27Antigen processing and presentation_Homo sapiens_hsa046121.21416665
28MicroRNAs in cancer_Homo sapiens_hsa052061.15218789
29Oocyte meiosis_Homo sapiens_hsa041141.10759642
30Sulfur relay system_Homo sapiens_hsa041221.09907501
31Biosynthesis of amino acids_Homo sapiens_hsa012301.09240359
32Epstein-Barr virus infection_Homo sapiens_hsa051691.08859790
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01707988
34HTLV-I infection_Homo sapiens_hsa051661.01027030
35Herpes simplex infection_Homo sapiens_hsa051681.00516648
36Proteasome_Homo sapiens_hsa030500.98770569
37Pentose phosphate pathway_Homo sapiens_hsa000300.95794675
38Small cell lung cancer_Homo sapiens_hsa052220.93906899
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92593101
40Central carbon metabolism in cancer_Homo sapiens_hsa052300.91793679
41Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90419141
42Alcoholism_Homo sapiens_hsa050340.88134915
43Thyroid cancer_Homo sapiens_hsa052160.87760063
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84262102
45mTOR signaling pathway_Homo sapiens_hsa041500.84130330
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.82875090
47Lysine degradation_Homo sapiens_hsa003100.80610492
48Adherens junction_Homo sapiens_hsa045200.80508335
49Hippo signaling pathway_Homo sapiens_hsa043900.75840528
50Pyruvate metabolism_Homo sapiens_hsa006200.75636570
51Purine metabolism_Homo sapiens_hsa002300.74294858
52TGF-beta signaling pathway_Homo sapiens_hsa043500.74110214
53Chronic myeloid leukemia_Homo sapiens_hsa052200.73353787
54Colorectal cancer_Homo sapiens_hsa052100.68927695
55Vitamin B6 metabolism_Homo sapiens_hsa007500.68875431
56Basal cell carcinoma_Homo sapiens_hsa052170.68539650
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67428519
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65177352
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61802821
60HIF-1 signaling pathway_Homo sapiens_hsa040660.60868415
61Legionellosis_Homo sapiens_hsa051340.60478353
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59422174
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.58970942
64Notch signaling pathway_Homo sapiens_hsa043300.57458268
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57018600
66Acute myeloid leukemia_Homo sapiens_hsa052210.56503869
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56424489
68Bladder cancer_Homo sapiens_hsa052190.54391553
69Folate biosynthesis_Homo sapiens_hsa007900.53893228
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.52905760
71Steroid biosynthesis_Homo sapiens_hsa001000.51321047
72Primary immunodeficiency_Homo sapiens_hsa053400.50343330
73Apoptosis_Homo sapiens_hsa042100.49054325
74Proteoglycans in cancer_Homo sapiens_hsa052050.48739308
75Viral myocarditis_Homo sapiens_hsa054160.48698887
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48028980
77Carbon metabolism_Homo sapiens_hsa012000.47950777
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47773033
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.47339431
80Measles_Homo sapiens_hsa051620.46551542
81Non-small cell lung cancer_Homo sapiens_hsa052230.46437416
82Prostate cancer_Homo sapiens_hsa052150.45552998
83Hepatitis B_Homo sapiens_hsa051610.45262925
84Pathways in cancer_Homo sapiens_hsa052000.44244625
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44223928
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42463930
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41535574
88Glioma_Homo sapiens_hsa052140.39890859
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39744041
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39414808
91Endometrial cancer_Homo sapiens_hsa052130.39180227
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37245134
93Tight junction_Homo sapiens_hsa045300.36775750
94Galactose metabolism_Homo sapiens_hsa000520.36374481
95Influenza A_Homo sapiens_hsa051640.36001637
96Dorso-ventral axis formation_Homo sapiens_hsa043200.35079686
97T cell receptor signaling pathway_Homo sapiens_hsa046600.35008309
98Hedgehog signaling pathway_Homo sapiens_hsa043400.34108251
99Wnt signaling pathway_Homo sapiens_hsa043100.33255900
100Fructose and mannose metabolism_Homo sapiens_hsa000510.29595165
101B cell receptor signaling pathway_Homo sapiens_hsa046620.28617169
102FoxO signaling pathway_Homo sapiens_hsa040680.28552623
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27854414
104Focal adhesion_Homo sapiens_hsa045100.27827592
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26616229
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.26261919
107AMPK signaling pathway_Homo sapiens_hsa041520.25788578
108N-Glycan biosynthesis_Homo sapiens_hsa005100.25295369
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.24671618
110Pancreatic cancer_Homo sapiens_hsa052120.24604953
111Glucagon signaling pathway_Homo sapiens_hsa049220.24178213
112Insulin signaling pathway_Homo sapiens_hsa049100.23858832
113Arginine biosynthesis_Homo sapiens_hsa002200.23768967
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23548455
115Shigellosis_Homo sapiens_hsa051310.23227152
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23175351
117Melanoma_Homo sapiens_hsa052180.22886527
118Fatty acid biosynthesis_Homo sapiens_hsa000610.22162127
119Renin-angiotensin system_Homo sapiens_hsa046140.21770944
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19624159
121Fatty acid elongation_Homo sapiens_hsa000620.17778651

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