URGCP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sodium ion export (GO:0071436)4.23957509
2response to pheromone (GO:0019236)4.04000789
3cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.97969583
4cell communication by electrical coupling (GO:0010644)3.80752220
5cellular potassium ion homeostasis (GO:0030007)3.34848051
6activation of protein kinase A activity (GO:0034199)3.33059545
7desmosome organization (GO:0002934)3.31388285
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.19296881
9carnitine shuttle (GO:0006853)3.18859039
10NADH metabolic process (GO:0006734)3.15694306
11cell communication involved in cardiac conduction (GO:0086065)3.11980261
12lysine catabolic process (GO:0006554)3.11566929
13lysine metabolic process (GO:0006553)3.11566929
14regulation of short-term neuronal synaptic plasticity (GO:0048172)3.03636324
15fatty acid transmembrane transport (GO:1902001)3.03502476
162-oxoglutarate metabolic process (GO:0006103)3.03117359
17regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.02675882
18positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.02623013
19plasma membrane repair (GO:0001778)2.98359481
20protein localization to endosome (GO:0036010)2.97858377
21synaptic vesicle maturation (GO:0016188)2.96558433
22adhesion of symbiont to host (GO:0044406)2.93296654
23adhesion of symbiont to host cell (GO:0044650)2.92777705
24virion attachment to host cell (GO:0019062)2.92777705
25tricarboxylic acid cycle (GO:0006099)2.92559154
26layer formation in cerebral cortex (GO:0021819)2.92253606
27regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.91665683
28COPI coating of Golgi vesicle (GO:0048205)2.86910085
29Golgi transport vesicle coating (GO:0048200)2.86910085
30regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.85604638
31regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.84730651
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.82743046
33locomotory exploration behavior (GO:0035641)2.82149580
34potassium ion import (GO:0010107)2.80897758
35regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.77966380
36negative regulation of potassium ion transmembrane transport (GO:1901380)2.77078398
37regulation of synapse structural plasticity (GO:0051823)2.73087105
38synaptic vesicle exocytosis (GO:0016079)2.68423443
39macroautophagy (GO:0016236)2.65217687
40tricarboxylic acid metabolic process (GO:0072350)2.64223137
41regulation of fatty acid oxidation (GO:0046320)2.62647670
42endothelial cell chemotaxis (GO:0035767)2.60101248
43succinate metabolic process (GO:0006105)2.59737718
44regulation of plasminogen activation (GO:0010755)2.59374273
45oxaloacetate metabolic process (GO:0006107)2.57308645
46carnitine transmembrane transport (GO:1902603)2.56659438
47regulation of extracellular matrix disassembly (GO:0010715)2.56650124
48positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.56552666
49hemidesmosome assembly (GO:0031581)2.55646304
50cerebellar Purkinje cell layer development (GO:0021680)2.53897617
51positive regulation of synapse maturation (GO:0090129)2.53559071
52neuromuscular process controlling posture (GO:0050884)2.52852218
53aspartate family amino acid catabolic process (GO:0009068)2.52303146
54cardiac muscle contraction (GO:0060048)2.51843994
55negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.51774336
56negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51189555
57regulation of vitamin metabolic process (GO:0030656)2.50922231
58sarcomere organization (GO:0045214)2.50433500
59regulation of ARF protein signal transduction (GO:0032012)2.50260993
60carnitine transport (GO:0015879)2.48655954
61amino-acid betaine transport (GO:0015838)2.48655954
62alpha-linolenic acid metabolic process (GO:0036109)2.48560592
63vocalization behavior (GO:0071625)2.47895011
64alanine transport (GO:0032328)2.45544221
65regulation of fatty acid beta-oxidation (GO:0031998)2.45470458
66synaptic vesicle docking involved in exocytosis (GO:0016081)2.44927196
67dicarboxylic acid biosynthetic process (GO:0043650)2.43129278
68cardiac myofibril assembly (GO:0055003)2.43062404
69ventricular cardiac muscle cell action potential (GO:0086005)2.42370048
70regulation of calcium ion transmembrane transport (GO:1903169)2.42362604
71regulation of calcium ion transmembrane transporter activity (GO:1901019)2.42362604
72cellular sodium ion homeostasis (GO:0006883)2.42044186
73mannose metabolic process (GO:0006013)2.41343453
74cellular ketone body metabolic process (GO:0046950)2.41337150
75regulation of cholesterol metabolic process (GO:0090181)2.41055502
76regulation of vitamin D biosynthetic process (GO:0060556)2.40733586
77positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.40003171
78potassium ion homeostasis (GO:0055075)2.36170070
79regulation of synaptic vesicle exocytosis (GO:2000300)2.35914436
80regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.34358234
81detection of calcium ion (GO:0005513)2.33273810
82creatine metabolic process (GO:0006600)2.32931812
83neurotransmitter secretion (GO:0007269)2.32635567
84retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.32539940
85regulation of membrane repolarization (GO:0060306)2.32065931
86endocytic recycling (GO:0032456)2.31472389
87positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.31242499
88protein retention in ER lumen (GO:0006621)2.30507728
89regulation of cholesterol homeostasis (GO:2000188)2.30057470
90negative regulation of cell size (GO:0045792)2.29948834
91fatty acid beta-oxidation (GO:0006635)2.29875877
92sarcoplasmic reticulum calcium ion transport (GO:0070296)2.29386316
93COPII vesicle coating (GO:0048208)2.29245042
94sulfur amino acid catabolic process (GO:0000098)2.29063515
95regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.29008134
96positive regulation of fatty acid beta-oxidation (GO:0032000)2.28497864
97regulation of cholesterol biosynthetic process (GO:0045540)2.28279247
98low-density lipoprotein particle clearance (GO:0034383)2.27401890
99regulation of neuronal synaptic plasticity (GO:0048168)2.26981993
100regulation of acyl-CoA biosynthetic process (GO:0050812)2.26849492
101glomerular basement membrane development (GO:0032836)2.26289826
102glutamate secretion (GO:0014047)2.25751660
103activation of MAPKKK activity (GO:0000185)2.25695925
104fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.24910735
105proline transport (GO:0015824)2.24184150
106cytoskeletal anchoring at plasma membrane (GO:0007016)2.23685118
107regulation of glucose import in response to insulin stimulus (GO:2001273)2.22702112
108regulation of synaptic vesicle transport (GO:1902803)2.22332121
109positive regulation of fatty acid oxidation (GO:0046321)2.22027708
110regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.21204628
111regulation of sodium ion transmembrane transporter activity (GO:2000649)2.21067832
112positive regulation of sodium ion transport (GO:0010765)2.20832498
113maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.20096698
114phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.20022104
115regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.19228919
116glycosphingolipid catabolic process (GO:0046479)2.19223159
117growth hormone secretion (GO:0030252)2.19127096
118glycogen catabolic process (GO:0005980)2.18355320
119regulation of glutamate receptor signaling pathway (GO:1900449)2.18266296
120neuronal ion channel clustering (GO:0045161)2.18158880
121regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.17577538
122cell migration involved in heart development (GO:0060973)2.16940589
123CDP-diacylglycerol metabolic process (GO:0046341)2.16461499
124glucan catabolic process (GO:0009251)2.16342288
125protein localization to synapse (GO:0035418)2.16148160
126fatty acid catabolic process (GO:0009062)2.15822357
127cell volume homeostasis (GO:0006884)2.15487869
128short-chain fatty acid metabolic process (GO:0046459)2.15443051
129adherens junction assembly (GO:0034333)2.14737988
130response to inactivity (GO:0014854)2.14728563
131regulation of actin filament-based movement (GO:1903115)2.14188349
132cell-substrate junction assembly (GO:0007044)2.13272285
133epithelial cell-cell adhesion (GO:0090136)2.12009755
134positive regulation of triglyceride biosynthetic process (GO:0010867)2.11772357
135regulation of p38MAPK cascade (GO:1900744)2.11358152
136fructose metabolic process (GO:0006000)2.11143076
137regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.11125663
138epoxygenase P450 pathway (GO:0019373)2.10707850
139activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.09679684
140regulation of membrane protein ectodomain proteolysis (GO:0051043)2.08977882
141negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.08023014
142glutamine family amino acid biosynthetic process (GO:0009084)2.07830819
143cell-substrate adherens junction assembly (GO:0007045)2.07607385
144focal adhesion assembly (GO:0048041)2.07607385
145insulin-like growth factor receptor signaling pathway (GO:0048009)2.07309278
146endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.07108609
147glycolipid catabolic process (GO:0019377)2.06662876
148negative regulation of fatty acid transport (GO:2000192)2.05142204
149positive regulation of lipoprotein lipase activity (GO:0051006)2.03343023
150positive regulation of triglyceride lipase activity (GO:0061365)2.03343023
151positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.02039924
152receptor recycling (GO:0001881)1.97235802
153semaphorin-plexin signaling pathway (GO:0071526)1.94532485
154positive regulation of protein dephosphorylation (GO:0035307)1.93855272
155activation of Rac GTPase activity (GO:0032863)1.93466825
156regulation of extracellular matrix organization (GO:1903053)1.93306178
157angiotensin maturation (GO:0002003)1.92181695
158diaphragm development (GO:0060539)1.92095406
159glucose 6-phosphate metabolic process (GO:0051156)1.91895514
160cell-cell junction maintenance (GO:0045217)1.91849799
161endoplasmic reticulum unfolded protein response (GO:0030968)1.91624209
162sphingolipid catabolic process (GO:0030149)1.91415661
163myelin maintenance (GO:0043217)1.91307444
164membrane lipid catabolic process (GO:0046466)1.90048604
165regulation of cholesterol storage (GO:0010885)1.90012847
166negative regulation of catenin import into nucleus (GO:0035414)1.89282992
167positive regulation of steroid biosynthetic process (GO:0010893)1.88122200
168response to magnesium ion (GO:0032026)1.87972971
169urea cycle (GO:0000050)1.87287471
170endoplasmic reticulum organization (GO:0007029)1.87280056
1714-hydroxyproline metabolic process (GO:0019471)1.87239189
172negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)1.86065762
173cell adhesion mediated by integrin (GO:0033627)1.85871171
174vesicle coating (GO:0006901)1.84824946
175endocardial cushion development (GO:0003197)1.84481820
176urea metabolic process (GO:0019627)1.82798161
177dopamine receptor signaling pathway (GO:0007212)1.82715554
178positive regulation of nuclease activity (GO:0032075)1.82662129
179glutathione biosynthetic process (GO:0006750)1.82449879

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.39455752
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.30955603
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.29951741
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.79636403
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.45049043
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.30028510
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.23601566
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.08034644
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.07556885
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.07148880
11DROSHA_22980978_ChIP-Seq_HELA_Human2.05956194
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97053670
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95984365
14RARB_27405468_Chip-Seq_BRAIN_Mouse1.93646388
15MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92425120
16EZH2_22144423_ChIP-Seq_EOC_Human1.89656508
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89451110
18LXR_22292898_ChIP-Seq_THP-1_Human1.84880551
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84858758
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.83493031
21ZNF263_19887448_ChIP-Seq_K562_Human1.81153972
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78622338
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.76610924
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.75954263
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74521283
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73965017
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67473246
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67473246
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66619338
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.66324310
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66269831
32* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63851881
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.63324294
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63176366
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.62362510
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61628971
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61022750
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58669713
39* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56848267
40REST_21632747_ChIP-Seq_MESCs_Mouse1.56519815
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.53554285
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.51659741
43CLOCK_20551151_ChIP-Seq_293T_Human1.49809071
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48903735
45* KDM2B_26808549_Chip-Seq_K562_Human1.44860791
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44828299
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44350106
48ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42730519
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.39796433
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36934471
51GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33780126
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33126411
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32452453
54P63_26484246_Chip-Seq_KERATINOCYTES_Human1.31783880
55TP53_22127205_ChIP-Seq_IMR90_Human1.31248144
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.30186233
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29981298
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.29925725
59GATA1_22025678_ChIP-Seq_K562_Human1.29607770
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.28637265
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27960716
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25969200
63* KDM2B_26808549_Chip-Seq_DND41_Human1.25604406
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.23543344
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20945317
66CTCF_27219007_Chip-Seq_Bcells_Human1.20578736
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20577264
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17095335
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17090410
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17036614
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16910613
72RUNX1_27514584_Chip-Seq_MCF-7_Human1.16496597
73TCF7_22412390_ChIP-Seq_EML_Mouse1.16224414
74TBX20_22328084_ChIP-Seq_HEART_Mouse1.15893024
75TBX20_22080862_ChIP-Seq_HEART_Mouse1.15893024
76BCOR_27268052_Chip-Seq_Bcells_Human1.15888468
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15800331
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15558878
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15508311
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15422313
81GATA1_19941826_ChIP-Seq_K562_Human1.14614266
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.14551871
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14218733
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13943331
85CDX2_20551321_ChIP-Seq_CACO-2_Human1.11525810
86* TET1_21490601_ChIP-Seq_MESCs_Mouse1.08337733
87TP53_23651856_ChIP-Seq_MEFs_Mouse1.08110897
88SMC4_20622854_ChIP-Seq_HELA_Human1.06772084
89CREB1_26743006_Chip-Seq_LNCaP_Human1.05086088
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04218861
91SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03832905
92SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03832905
93RACK7_27058665_Chip-Seq_MCF-7_Human1.02660738
94SOX2_20726797_ChIP-Seq_SW620_Human1.02460830
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.02189814
96ATF3_27146783_Chip-Seq_COLON_Human1.01766487
97VDR_21846776_ChIP-Seq_THP-1_Human1.01531218
98SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01257872
99SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01237096
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00464397
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00404221
102SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00283918
103UBF1/2_26484160_Chip-Seq_HMECs_Human1.00236090
104NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99106208
105FOXA2_19822575_ChIP-Seq_HepG2_Human0.99073926
106ESR1_20079471_ChIP-ChIP_T-47D_Human0.98489841
107RING1B_27294783_Chip-Seq_ESCs_Mouse0.98207824
108KLF4_19829295_ChIP-Seq_ESCs_Human0.97591363
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97517729
110BCL6_27268052_Chip-Seq_Bcells_Human0.96798023
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96775750
112AR_21572438_ChIP-Seq_LNCaP_Human0.96712155
113TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.96598450
114CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96223290
115RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96066515
116RARB_24833708_ChIP-Seq_LIVER_Mouse0.95929148
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95485436
118TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95434842
119ETS1_21867929_ChIP-Seq_TH2_Mouse0.94055779
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93776825
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93708589
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92896195
123ELK3_25401928_ChIP-Seq_HUVEC_Human0.92766740
124JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92606300
125P68_20966046_ChIP-Seq_HELA_Human0.92471887
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91596649
127RXR_22108803_ChIP-Seq_LS180_Human0.91530977
128SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91350301
129ZNF274_21170338_ChIP-Seq_K562_Hela0.90600574
130KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89394990
131GATA2_21666600_ChIP-Seq_HMVEC_Human0.89142875
132DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88784074
133P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86508954
134KDM2B_26808549_Chip-Seq_JURKAT_Human0.86268751
135TP63_22573176_ChIP-Seq_HFKS_Human0.86210014
136PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81591302
137MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.81160133
138TET1_21451524_ChIP-Seq_MESCs_Mouse0.80701648
139SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80180631
140OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79578622
141ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78917063
142GATA2_19941826_ChIP-Seq_K562_Human0.78622792
143EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.76922851

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.75700239
2MP0002837_dystrophic_cardiac_calcinosis3.56614538
3MP0005058_abnormal_lysosome_morphology2.97258141
4MP0000751_myopathy2.94930708
5MP0005451_abnormal_body_composition2.65065353
6MP0005360_urolithiasis2.56069139
7MP0002909_abnormal_adrenal_gland2.55522615
8MP0002139_abnormal_hepatobiliary_system2.47455883
9MP0004130_abnormal_muscle_cell2.45646724
10MP0008438_abnormal_cutaneous_collagen2.31385686
11MP0004270_analgesia2.21013946
12MP0004084_abnormal_cardiac_muscle2.10108208
13MP0003635_abnormal_synaptic_transmissio2.09609487
14MP0005423_abnormal_somatic_nervous2.07865763
15MP0004215_abnormal_myocardial_fiber2.05354095
16MP0010234_abnormal_vibrissa_follicle2.04813986
17MP0004036_abnormal_muscle_relaxation2.03887131
18MP0003329_amyloid_beta_deposits2.02615968
19MP0009840_abnormal_foam_cell2.00666113
20MP0000013_abnormal_adipose_tissue1.89987769
21MP0005085_abnormal_gallbladder_physiolo1.85322818
22MP0003646_muscle_fatigue1.81407374
23MP0005330_cardiomyopathy1.80362963
24MP0004145_abnormal_muscle_electrophysio1.79851186
25MP0003172_abnormal_lysosome_physiology1.78479714
26MP0002822_catalepsy1.76067747
27MP0005365_abnormal_bile_salt1.75500350
28MP0000749_muscle_degeneration1.75372862
29MP0000747_muscle_weakness1.73478057
30MP0002332_abnormal_exercise_endurance1.72158051
31MP0005670_abnormal_white_adipose1.70466117
32MP0010329_abnormal_lipoprotein_level1.66334160
33MP0002063_abnormal_learning/memory/cond1.60910444
34MP0009780_abnormal_chondrocyte_physiolo1.60650048
35MP0008961_abnormal_basal_metabolism1.59645750
36MP0002064_seizures1.50902624
37MP0009745_abnormal_behavioral_response1.48065345
38MP0009046_muscle_twitch1.46508643
39MP0003252_abnormal_bile_duct1.46207855
40MP0001849_ear_inflammation1.45472930
41MP0003137_abnormal_impulse_conducting1.45303450
42MP0004087_abnormal_muscle_fiber1.44822505
43MP0005535_abnormal_body_temperature1.42215823
44MP0008875_abnormal_xenobiotic_pharmacok1.40503287
45MP0005666_abnormal_adipose_tissue1.38956725
46MP0003195_calcinosis1.36558548
47MP0003091_abnormal_cell_migration1.34449350
48MP0000604_amyloidosis1.31752003
49MP0003880_abnormal_central_pattern1.31550234
50MP0002269_muscular_atrophy1.29843713
51MP0005620_abnormal_muscle_contractility1.29479283
52MP0001501_abnormal_sleep_pattern1.26250381
53MP0004510_myositis1.24784798
54MP0002972_abnormal_cardiac_muscle1.24637410
55MP0002896_abnormal_bone_mineralization1.24414120
56MP0002078_abnormal_glucose_homeostasis1.23309477
57MP0002118_abnormal_lipid_homeostasis1.22453457
58MP0001661_extended_life_span1.21339885
59MP0003879_abnormal_hair_cell1.21199939
60MP0002234_abnormal_pharynx_morphology1.19899651
61MP0005375_adipose_tissue_phenotype1.19020078
62MP0005332_abnormal_amino_acid1.18831119
63MP0004085_abnormal_heartbeat1.18593261
64MP0005257_abnormal_intraocular_pressure1.17674575
65MP0004043_abnormal_pH_regulation1.17080827
66MP0001348_abnormal_lacrimal_gland1.16792084
67MP0002272_abnormal_nervous_system1.16082795
68MP0002733_abnormal_thermal_nociception1.15900524
69MP0008569_lethality_at_weaning1.15802165
70MP0003300_gastrointestinal_ulcer1.15793363
71MP0003453_abnormal_keratinocyte_physiol1.14562516
72MP0008775_abnormal_heart_ventricle1.12793445
73MP0004858_abnormal_nervous_system1.12613309
74MP0005023_abnormal_wound_healing1.11911399
75MP0005595_abnormal_vascular_smooth1.11683063
76MP0005584_abnormal_enzyme/coenzyme_acti1.11649683
77MP0009384_cardiac_valve_regurgitation1.10760760
78MP0002971_abnormal_brown_adipose1.10548827
79MP0008260_abnormal_autophagy1.10101854
80MP0000003_abnormal_adipose_tissue1.07311289
81MP0003633_abnormal_nervous_system1.06702776
82MP0003634_abnormal_glial_cell1.06261858
83MP0005319_abnormal_enzyme/_coenzyme1.06193008
84MP0002572_abnormal_emotion/affect_behav1.05581324
85MP0002106_abnormal_muscle_physiology1.05191812
86MP0000759_abnormal_skeletal_muscle1.04761314
87MP0006138_congestive_heart_failure1.04360822
88MP0005083_abnormal_biliary_tract1.04347618
89MP0002060_abnormal_skin_morphology1.04067765
90MP0001544_abnormal_cardiovascular_syste1.03739814
91MP0005385_cardiovascular_system_phenoty1.03739814
92MP0001440_abnormal_grooming_behavior1.02636758
93MP0005166_decreased_susceptibility_to1.02037226
94MP0002877_abnormal_melanocyte_morpholog1.02028962
95MP0004233_abnormal_muscle_weight1.01548563
96MP0000733_abnormal_muscle_development1.01492138
97MP0003183_abnormal_peptide_metabolism1.01426761
98MP0001664_abnormal_digestion1.00529498
99MP0002734_abnormal_mechanical_nocicepti0.99729923
100MP0001502_abnormal_circadian_rhythm0.99723764
101MP0005076_abnormal_cell_differentiation0.99534289
102MP0001958_emphysema0.99106526
103MP0001970_abnormal_pain_threshold0.98865145
104MP0003566_abnormal_cell_adhesion0.98304014
105MP0004185_abnormal_adipocyte_glucose0.97787156
106MP0000230_abnormal_systemic_arterial0.97374052
107MP0009643_abnormal_urine_homeostasis0.97348593
108MP0004811_abnormal_neuron_physiology0.97287965
109MP0003075_altered_response_to0.96960775
110MP0004484_altered_response_of0.96748729
111MP0001666_abnormal_nutrient_absorption0.96678968
112MP0005409_darkened_coat_color0.96461229
113MP0005645_abnormal_hypothalamus_physiol0.96450366
114MP0006036_abnormal_mitochondrial_physio0.95527337
115MP0003191_abnormal_cellular_cholesterol0.93359956
116MP0000609_abnormal_liver_physiology0.92805672
117MP0003690_abnormal_glial_cell0.92639037
118MP0002090_abnormal_vision0.92391500
119MP0008874_decreased_physiological_sensi0.91232300
120MP0005503_abnormal_tendon_morphology0.90958781
121MP0000678_abnormal_parathyroid_gland0.90540629
122MP0001765_abnormal_ion_homeostasis0.90198634
123MP0003303_peritoneal_inflammation0.89754120
124MP0000750_abnormal_muscle_regeneration0.89150040
125MP0003705_abnormal_hypodermis_morpholog0.88213095
126MP0004947_skin_inflammation0.88075544
127MP0003279_aneurysm0.88032565
128MP0003283_abnormal_digestive_organ0.86681952
129MP0005448_abnormal_energy_balance0.86043569
130MP0001968_abnormal_touch/_nociception0.85571017
131MP0005167_abnormal_blood-brain_barrier0.83763511
132MP0000920_abnormal_myelination0.83355007
133MP0005165_increased_susceptibility_to0.83312756
134MP0005369_muscle_phenotype0.82995596
135MP0003045_fibrosis0.82092050
136MP0000467_abnormal_esophagus_morphology0.81464776
137MP0003806_abnormal_nucleotide_metabolis0.81255706
138MP0010352_gastrointestinal_tract_polyps0.79542548
139MP0002138_abnormal_hepatobiliary_system0.77279013
140MP0004019_abnormal_vitamin_homeostasis0.75911949
141MP0002108_abnormal_muscle_morphology0.75109901
142MP0002876_abnormal_thyroid_physiology0.74070745
143MP0005334_abnormal_fat_pad0.73132511
144MP0008004_abnormal_stomach_pH0.70588772
145MP0002089_abnormal_postnatal_growth/wei0.70535171
146MP0001756_abnormal_urination0.70135129
147MP0002254_reproductive_system_inflammat0.67792562

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)3.80831128
2Sudden death (HP:0001699)3.77388154
3Ketoacidosis (HP:0001993)3.49132169
4Visual hallucinations (HP:0002367)3.31933022
5Myoglobinuria (HP:0002913)3.30646777
6Bundle branch block (HP:0011710)3.27576916
7Stridor (HP:0010307)3.06343931
8Abnormality of polysaccharide metabolism (HP:0011012)2.95517711
9Abnormality of glycosaminoglycan metabolism (HP:0004371)2.95517711
10Abnormality of mucopolysaccharide metabolism (HP:0011020)2.95517711
11Urinary glycosaminoglycan excretion (HP:0003541)2.89906535
12Mucopolysacchariduria (HP:0008155)2.89906535
13Myokymia (HP:0002411)2.87009532
14Ketosis (HP:0001946)2.82883204
15Asymmetric septal hypertrophy (HP:0001670)2.79699773
16Dysostosis multiplex (HP:0000943)2.78245681
17Focal motor seizures (HP:0011153)2.78083510
18Hyporeflexia of lower limbs (HP:0002600)2.76283428
19Hypoglycemic coma (HP:0001325)2.75120519
20Abnormality of glycosphingolipid metabolism (HP:0004343)2.72073468
21Abnormality of glycolipid metabolism (HP:0010969)2.72073468
22Abnormality of liposaccharide metabolism (HP:0010968)2.72073468
23Muscle fiber splitting (HP:0003555)2.72060061
24Distal lower limb amyotrophy (HP:0008944)2.69518477
25Syncope (HP:0001279)2.68630680
26Exercise-induced muscle cramps (HP:0003710)2.67360112
27Upper limb amyotrophy (HP:0009129)2.66948173
28Distal upper limb amyotrophy (HP:0007149)2.66948173
29Atrioventricular block (HP:0001678)2.65463362
30Ventricular fibrillation (HP:0001663)2.61795105
31Vertebral compression fractures (HP:0002953)2.61321659
32Abnormal eating behavior (HP:0100738)2.61079276
33Neurofibrillary tangles (HP:0002185)2.59328761
34Protrusio acetabuli (HP:0003179)2.57747275
35Xanthomatosis (HP:0000991)2.57008398
36Difficulty running (HP:0009046)2.56724775
37Prolonged QT interval (HP:0001657)2.56399954
38Mitral stenosis (HP:0001718)2.53267869
39J-shaped sella turcica (HP:0002680)2.49342853
40Hydroxyprolinuria (HP:0003080)2.48284739
41Abnormality of proline metabolism (HP:0010907)2.48284739
42Heart block (HP:0012722)2.46235419
43Pheochromocytoma (HP:0002666)2.45362032
44Cervical subluxation (HP:0003308)2.44519474
45Gout (HP:0001997)2.40862738
46Abnormal atrioventricular conduction (HP:0005150)2.39021005
47Ventricular arrhythmia (HP:0004308)2.37819753
48Loss of speech (HP:0002371)2.37531802
49Abnormality of the lower motor neuron (HP:0002366)2.36703657
50Systemic lupus erythematosus (HP:0002725)2.36610624
51Focal seizures (HP:0007359)2.36217198
52Hand muscle atrophy (HP:0009130)2.33889096
53Thin bony cortex (HP:0002753)2.32566928
54Abnormality of the calf musculature (HP:0001430)2.30277531
55Neuroendocrine neoplasm (HP:0100634)2.29166612
56Palpitations (HP:0001962)2.28961999
57Hypoalphalipoproteinemia (HP:0003233)2.28249959
58Calf muscle hypertrophy (HP:0008981)2.28243044
59Increased variability in muscle fiber diameter (HP:0003557)2.26633839
60Difficulty climbing stairs (HP:0003551)2.25647275
61Premature rupture of membranes (HP:0001788)2.25633017
62Atrophic scars (HP:0001075)2.22952556
63Depression (HP:0000716)2.22823947
64Right ventricular cardiomyopathy (HP:0011663)2.22530084
65Skin nodule (HP:0200036)2.21535037
66EMG: myopathic abnormalities (HP:0003458)2.19226559
67Ventricular tachycardia (HP:0004756)2.18581079
68Bulbar palsy (HP:0001283)2.18005095
69Muscle hypertrophy of the lower extremities (HP:0008968)2.17346155
70Increased connective tissue (HP:0009025)2.17052635
71Broad face (HP:0000283)2.15977655
72Abnormality of the Achilles tendon (HP:0005109)2.14615204
73Ragged-red muscle fibers (HP:0003200)2.14201198
74Supranuclear gaze palsy (HP:0000605)2.13977487
75Hyperglycinuria (HP:0003108)2.13347942
76Atrial fibrillation (HP:0005110)2.13207235
77Myotonia (HP:0002486)2.13167921
78Abnormal EKG (HP:0003115)2.12590675
79Rhabdomyolysis (HP:0003201)2.12492538
80Cerebral aneurysm (HP:0004944)2.12295455
81Malnutrition (HP:0004395)2.10973548
82Hyperinsulinemic hypoglycemia (HP:0000825)2.09278040
83Achilles tendon contracture (HP:0001771)2.09127836
84Primary atrial arrhythmia (HP:0001692)2.08681891
85Hyperammonemia (HP:0001987)2.06760598
86Back pain (HP:0003418)2.05795098
87Nuclear cataract (HP:0100018)2.05619282
88Short nail (HP:0001799)2.04804789
89Centrally nucleated skeletal muscle fibers (HP:0003687)2.04642482
90Spinal rigidity (HP:0003306)2.03807003
91Absence seizures (HP:0002121)2.03746428
92Dysmetric saccades (HP:0000641)2.03518458
93Obstructive sleep apnea (HP:0002870)2.02603234
94Abnormality of fatty-acid metabolism (HP:0004359)2.02201099
95Impaired vibration sensation in the lower limbs (HP:0002166)2.02051732
96Increased cerebral lipofuscin (HP:0011813)2.02025470
97Lower limb amyotrophy (HP:0007210)2.01322432
98Anxiety (HP:0000739)2.01039920
99Deep venous thrombosis (HP:0002625)2.00557834
100Hyperlipoproteinemia (HP:0010980)2.00505892
101Abnormality of aromatic amino acid family metabolism (HP:0004338)2.00239478
102Hyperparathyroidism (HP:0000843)1.98454241
103Polyphagia (HP:0002591)1.98382478
104Round ear (HP:0100830)1.97728265
105Rapidly progressive (HP:0003678)1.97356656
106Distal lower limb muscle weakness (HP:0009053)1.97108897
107Fragile skin (HP:0001030)1.96763264
108Supraventricular tachycardia (HP:0004755)1.95362802
109Global brain atrophy (HP:0002283)1.94518490
110Agitation (HP:0000713)1.94033533
111Late onset (HP:0003584)1.93638271
112Supraventricular arrhythmia (HP:0005115)1.93067645
113Type 1 muscle fiber predominance (HP:0003803)1.91776761
114Ankle clonus (HP:0011448)1.90612082
115Insulin-resistant diabetes mellitus (HP:0000831)1.89829987
116Myopathic facies (HP:0002058)1.89099825
117Cerebral inclusion bodies (HP:0100314)1.88638375
118Abnormality of skeletal muscle fiber size (HP:0012084)1.88293975
119Abnormality of glutamine family amino acid metabolism (HP:0010902)1.88255199
120Mesangial abnormality (HP:0001966)1.87441068
121Long toe (HP:0010511)1.86537508
122Failure to thrive in infancy (HP:0001531)1.85667911
123Insomnia (HP:0100785)1.85193113
124Generalized tonic-clonic seizures (HP:0002069)1.85030017
125Mildly elevated creatine phosphokinase (HP:0008180)1.84198547
126Frequent falls (HP:0002359)1.83026400
127Action tremor (HP:0002345)1.82491217
128Hypercortisolism (HP:0001578)1.81941691
129Abnormality of monocarboxylic acid metabolism (HP:0010996)1.81710939
130Complement deficiency (HP:0004431)1.80962615
131Hyperglycemia (HP:0003074)1.80709595
132Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80694976
133Growth hormone excess (HP:0000845)1.80596483
134Increased neuronal autofluorescent lipopigment (HP:0002074)1.80326019
135Abnormal gallbladder physiology (HP:0012438)1.79778952
136Cholecystitis (HP:0001082)1.79778952
137Polycythemia (HP:0001901)1.79751923
138Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.79742893
139Lipoatrophy (HP:0100578)1.79019229
140Cerebral hemorrhage (HP:0001342)1.78880773
141Torticollis (HP:0000473)1.78733485
142Muscle stiffness (HP:0003552)1.77989056
143Axonal loss (HP:0003447)1.77500419
144Dialeptic seizures (HP:0011146)1.77168099
145Status epilepticus (HP:0002133)1.76870170
146Hyperacusis (HP:0010780)1.76154372
147Neuronal loss in central nervous system (HP:0002529)1.75969757
148Postural instability (HP:0002172)1.75001504
149Truncal ataxia (HP:0002078)1.74424068
150Abnormality of complement system (HP:0005339)1.73103041
151Abnormality of carpal bone ossification (HP:0006257)1.72588767
152Wormian bones (HP:0002645)1.72537265
153Diaphragmatic weakness (HP:0009113)1.72246965
154Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71532080
155Onion bulb formation (HP:0003383)1.69886516
156Hemorrhage of the eye (HP:0011885)1.69185391
157Focal segmental glomerulosclerosis (HP:0000097)1.67837898
158Flat acetabular roof (HP:0003180)1.67318520
159Joint stiffness (HP:0001387)1.66908157
160Advanced eruption of teeth (HP:0006288)1.65889851
161Bradycardia (HP:0001662)1.65202117
162Apathy (HP:0000741)1.64835153
163Clonus (HP:0002169)1.57488649
164Hypoventilation (HP:0002791)1.57276376
165Generalized amyotrophy (HP:0003700)1.57044786
166Aneurysm (HP:0002617)1.56374536
167Muscle fiber inclusion bodies (HP:0100299)1.55679184
168Biconcave vertebral bodies (HP:0004586)1.55485375

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.86258008
2RIPK12.94583119
3IRAK32.77892107
4EPHA22.76125720
5MST1R2.65530692
6PKN22.48812859
7PHKG22.29923905
8PHKG12.29923905
9TTN2.29156224
10EPHA32.24791595
11LMTK22.18964784
12KSR22.14781716
13WNK31.91769632
14MAP3K91.88802554
15MAP3K31.88802543
16PAK61.84038286
17PRKD31.82759125
18NTRK31.80159798
19MAP2K31.79335143
20EPHA41.73499673
21DAPK21.73172616
22INSRR1.70615398
23MET1.67641004
24CAMKK11.64080915
25BCKDK1.57114123
26NTRK11.52766650
27NEK11.49835901
28ERN11.47288821
29PIM21.46047007
30AKT31.43930081
31CAMK1D1.40432476
32PTK21.40158593
33MAP2K61.39821133
34PAK31.34356132
35PDK41.33700231
36PDK31.33700231
37PRPF4B1.29118143
38TESK11.27280072
39MINK11.27223340
40TAOK11.25044588
41PDGFRA1.24679330
42MAP3K71.24671354
43PRKCH1.24554973
44EEF2K1.23802254
45RIPK41.22652155
46MAP2K41.19806035
47PINK11.18533691
48FGFR41.15017564
49MAP3K41.14435601
50LATS21.12057441
51SIK11.12043484
52TBK11.08716590
53MAP3K131.08369487
54SMG11.05238452
55PDPK11.04591920
56RET1.04161502
57MAPKAPK31.03979256
58MAP3K61.00594827
59MAP3K11.00453426
60STK380.98952317
61PDK10.98551907
62CAMKK20.98009559
63CDK50.97902757
64PTK60.96054781
65MTOR0.89274045
66ARAF0.89240495
67FER0.86657699
68OBSCN0.82983141
69KSR10.82705935
70ABL20.79308933
71FLT30.78904567
72MAP3K20.77900847
73DAPK30.77517157
74PRKG20.76373011
75NME20.75265890
76JAK10.75024372
77MAPK110.74924069
78PTK2B0.74558605
79MARK20.73536583
80MAP2K10.72700953
81FES0.71142872
82MAPK120.71099086
83GRK50.71078124
84TAOK20.70097856
85ICK0.68685802
86PRKD10.67925895
87TNIK0.67537346
88MAP2K20.67237334
89MYLK0.66780706
90CDK120.66669540
91CDC42BPA0.66065572
92PDGFRB0.65564317
93PRKAA10.64987957
94CAMK2D0.64598306
95MARK10.62484565
96TRPM70.62245454
97SIK20.61765865
98RPS6KA20.61271580
99ERBB20.60826704
100DMPK0.59592111
101MAP3K110.59311746
102JAK20.57881325
103EPHB10.57066830
104CAMK2B0.56856850
105PRKAA20.56744749
106PRKCG0.56325614
107PRKD20.56287543
108TNK20.55808945
109CCNB10.54496009
110CAMK10.52694044
111CAMK1G0.52553983
112STK110.52471772
113TYRO30.52031445
114DDR20.51734090
115NTRK20.51681522
116WNK40.51351603
117CAMK2G0.49050247
118CAMK2A0.48999148
119PDK20.48572405
120MAPK70.47804343
121DAPK10.47360604
122PRKCZ0.47308203
123MUSK0.47159401
124MAP3K140.46890891
125ROCK10.46428456
126CHUK0.46144359
127SCYL20.44133309
128MAP3K120.44110151
129PAK20.44093980
130TGFBR20.44016952
131IRAK20.43427062
132PRKACG0.42744960
133ZAP700.42208629
134LIMK10.41921536
135SGK30.40599177
136CDK90.39822274
137PIK3CA0.39582440
138PRKCI0.39072988
139SGK2230.37947316
140SGK4940.37947316

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.62423927
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.61408018
3Nitrogen metabolism_Homo sapiens_hsa009102.55078171
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.54135498
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.36601478
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.22458069
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89802106
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.85853206
9Fatty acid degradation_Homo sapiens_hsa000711.83797633
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.80225804
11Arginine biosynthesis_Homo sapiens_hsa002201.74114603
12Insulin secretion_Homo sapiens_hsa049111.65190747
13Bile secretion_Homo sapiens_hsa049761.62414309
14Synaptic vesicle cycle_Homo sapiens_hsa047211.53619325
15Cardiac muscle contraction_Homo sapiens_hsa042601.52350197
16Butanoate metabolism_Homo sapiens_hsa006501.47752930
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46712826
18Propanoate metabolism_Homo sapiens_hsa006401.46710756
19Dilated cardiomyopathy_Homo sapiens_hsa054141.43774296
20Fatty acid metabolism_Homo sapiens_hsa012121.42570879
21Circadian entrainment_Homo sapiens_hsa047131.42379588
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39699989
23GABAergic synapse_Homo sapiens_hsa047271.39133480
24Vitamin B6 metabolism_Homo sapiens_hsa007501.37913861
25Salivary secretion_Homo sapiens_hsa049701.37859269
26PPAR signaling pathway_Homo sapiens_hsa033201.36145828
27Olfactory transduction_Homo sapiens_hsa047401.35850337
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35182326
29Gastric acid secretion_Homo sapiens_hsa049711.32789720
30Lysosome_Homo sapiens_hsa041421.30225881
31Vibrio cholerae infection_Homo sapiens_hsa051101.26799981
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26443225
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25127313
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23494488
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21020834
36Histidine metabolism_Homo sapiens_hsa003401.20414901
37Type II diabetes mellitus_Homo sapiens_hsa049301.19726750
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.19611508
39Carbon metabolism_Homo sapiens_hsa012001.15261104
40Morphine addiction_Homo sapiens_hsa050321.14026279
41Arginine and proline metabolism_Homo sapiens_hsa003301.12891924
42Sulfur relay system_Homo sapiens_hsa041221.11011297
43Renin secretion_Homo sapiens_hsa049241.10814447
44Long-term potentiation_Homo sapiens_hsa047201.09782877
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08583063
46Tryptophan metabolism_Homo sapiens_hsa003801.07115743
47Oxytocin signaling pathway_Homo sapiens_hsa049211.04366683
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02988515
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01862117
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01207405
51Pyruvate metabolism_Homo sapiens_hsa006200.99129626
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.96739664
53Amphetamine addiction_Homo sapiens_hsa050310.96236182
54Cholinergic synapse_Homo sapiens_hsa047250.95666367
55Sphingolipid metabolism_Homo sapiens_hsa006000.95614761
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92531139
57Glucagon signaling pathway_Homo sapiens_hsa049220.91621703
58Glutamatergic synapse_Homo sapiens_hsa047240.90950191
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90545510
60Calcium signaling pathway_Homo sapiens_hsa040200.90250152
61Dopaminergic synapse_Homo sapiens_hsa047280.90147044
62Gap junction_Homo sapiens_hsa045400.88969957
63Insulin resistance_Homo sapiens_hsa049310.88387282
64Mineral absorption_Homo sapiens_hsa049780.88264015
65Caffeine metabolism_Homo sapiens_hsa002320.88178090
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87896396
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87203238
68Nicotine addiction_Homo sapiens_hsa050330.86337029
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86168566
70TNF signaling pathway_Homo sapiens_hsa046680.85606458
71Protein digestion and absorption_Homo sapiens_hsa049740.84154941
72GnRH signaling pathway_Homo sapiens_hsa049120.82392612
73Complement and coagulation cascades_Homo sapiens_hsa046100.82056286
74Insulin signaling pathway_Homo sapiens_hsa049100.81118658
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79760167
76Fat digestion and absorption_Homo sapiens_hsa049750.79512944
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.79222366
78Cocaine addiction_Homo sapiens_hsa050300.77616785
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76575330
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.76373443
81Starch and sucrose metabolism_Homo sapiens_hsa005000.74938026
82Pentose phosphate pathway_Homo sapiens_hsa000300.74889837
83Glycerolipid metabolism_Homo sapiens_hsa005610.72956721
84Biosynthesis of amino acids_Homo sapiens_hsa012300.72662163
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71429686
86Ovarian steroidogenesis_Homo sapiens_hsa049130.71411916
87cAMP signaling pathway_Homo sapiens_hsa040240.71194808
88Pertussis_Homo sapiens_hsa051330.69319142
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68665220
90Renin-angiotensin system_Homo sapiens_hsa046140.67872258
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67792531
92Pancreatic secretion_Homo sapiens_hsa049720.66614927
93beta-Alanine metabolism_Homo sapiens_hsa004100.66564860
94Estrogen signaling pathway_Homo sapiens_hsa049150.65373716
95Fatty acid biosynthesis_Homo sapiens_hsa000610.62841768
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62679181
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61626737
98Fructose and mannose metabolism_Homo sapiens_hsa000510.61565674
99AMPK signaling pathway_Homo sapiens_hsa041520.60993464
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60853554
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60527267
102Amoebiasis_Homo sapiens_hsa051460.59960937
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59843742
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59154768
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.59132549
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58961296
107Thyroid hormone synthesis_Homo sapiens_hsa049180.58440533
108Taste transduction_Homo sapiens_hsa047420.58405268
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.58313152
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.57881928
111Glioma_Homo sapiens_hsa052140.55878475
112ABC transporters_Homo sapiens_hsa020100.55062966
113Focal adhesion_Homo sapiens_hsa045100.54865889
114Prion diseases_Homo sapiens_hsa050200.54742481
115Vitamin digestion and absorption_Homo sapiens_hsa049770.53791833
116Hepatitis C_Homo sapiens_hsa051600.53083606
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.52792125
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52640660
119Inositol phosphate metabolism_Homo sapiens_hsa005620.50777179
120ECM-receptor interaction_Homo sapiens_hsa045120.50757021
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50532675
122Bladder cancer_Homo sapiens_hsa052190.49943732
123Prolactin signaling pathway_Homo sapiens_hsa049170.49177543
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.49174675
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.48243602
126Long-term depression_Homo sapiens_hsa047300.48107478
127Sulfur metabolism_Homo sapiens_hsa009200.48069801
128Peroxisome_Homo sapiens_hsa041460.48030508
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47529230
130mTOR signaling pathway_Homo sapiens_hsa041500.46893029
131VEGF signaling pathway_Homo sapiens_hsa043700.45860232
132Alzheimers disease_Homo sapiens_hsa050100.43606074
133Circadian rhythm_Homo sapiens_hsa047100.43235151
134Phenylalanine metabolism_Homo sapiens_hsa003600.38726421
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38110395
136Galactose metabolism_Homo sapiens_hsa000520.37669381
137Collecting duct acid secretion_Homo sapiens_hsa049660.36751656

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