URI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA synthesis involved in DNA repair (GO:0000731)5.22973603
2DNA unwinding involved in DNA replication (GO:0006268)5.04743432
3synapsis (GO:0007129)4.99800545
4folic acid-containing compound biosynthetic process (GO:0009396)4.96283311
5nuclear pore organization (GO:0006999)4.69266422
6nuclear pore complex assembly (GO:0051292)4.67220210
7negative regulation of DNA repair (GO:0045738)4.54673026
8maturation of SSU-rRNA (GO:0030490)4.49804470
9IMP biosynthetic process (GO:0006188)4.44249576
10DNA replication initiation (GO:0006270)4.35550300
11chromosome organization involved in meiosis (GO:0070192)4.32368962
12sister chromatid segregation (GO:0000819)4.25655647
13mitotic sister chromatid segregation (GO:0000070)4.22900594
14DNA strand elongation involved in DNA replication (GO:0006271)4.21549504
15ribosomal small subunit assembly (GO:0000028)4.09467501
16IMP metabolic process (GO:0046040)4.04385308
17nucleobase biosynthetic process (GO:0046112)4.03635758
18DNA strand elongation (GO:0022616)4.00589572
19somatic diversification of immune receptors via somatic mutation (GO:0002566)3.91077535
20somatic hypermutation of immunoglobulin genes (GO:0016446)3.91077535
21telomere maintenance via semi-conservative replication (GO:0032201)3.89173065
22formation of translation preinitiation complex (GO:0001731)3.79800800
23mitotic sister chromatid cohesion (GO:0007064)3.77045396
24DNA duplex unwinding (GO:0032508)3.72742193
25DNA replication-dependent nucleosome organization (GO:0034723)3.69560175
26DNA replication-dependent nucleosome assembly (GO:0006335)3.69560175
27DNA geometric change (GO:0032392)3.69014586
28DNA replication checkpoint (GO:0000076)3.66855771
29mitotic nuclear envelope disassembly (GO:0007077)3.64230036
30purine nucleobase biosynthetic process (GO:0009113)3.62152677
31regulation of translational fidelity (GO:0006450)3.61206255
32regulation of transcription from RNA polymerase I promoter (GO:0006356)3.59064448
33regulation of histone H3-K9 methylation (GO:0051570)3.58405499
34ribosome assembly (GO:0042255)3.57235264
35regulation of helicase activity (GO:0051095)3.55598452
36regulation of nucleobase-containing compound transport (GO:0032239)3.54664706
37ribosomal small subunit biogenesis (GO:0042274)3.48909517
38histone H3-K36 demethylation (GO:0070544)3.47032994
39synaptonemal complex assembly (GO:0007130)3.46530427
40chromatin remodeling at centromere (GO:0031055)3.46204740
41histone H3-K9 demethylation (GO:0033169)3.46158253
42male meiosis I (GO:0007141)3.45836264
43negative regulation of histone methylation (GO:0031061)3.41576974
44telomere maintenance via recombination (GO:0000722)3.41497790
45regulation of DNA endoreduplication (GO:0032875)3.40809842
46membrane disassembly (GO:0030397)3.39861012
47nuclear envelope disassembly (GO:0051081)3.39861012
48meiotic chromosome segregation (GO:0045132)3.38917268
49pore complex assembly (GO:0046931)3.37127189
50mitotic recombination (GO:0006312)3.36968109
51protein localization to kinetochore (GO:0034501)3.34678582
52regulation of RNA export from nucleus (GO:0046831)3.30995721
53heterochromatin organization (GO:0070828)3.25414616
54pteridine-containing compound biosynthetic process (GO:0042559)3.24984093
55intra-S DNA damage checkpoint (GO:0031573)3.24965307
56regulation of gene silencing by RNA (GO:0060966)3.24962841
57regulation of posttranscriptional gene silencing (GO:0060147)3.24962841
58regulation of gene silencing by miRNA (GO:0060964)3.24962841
59regulation of centriole replication (GO:0046599)3.24304796
60regulation of nuclear cell cycle DNA replication (GO:0033262)3.22981761
61pre-miRNA processing (GO:0031054)3.22960912
62nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.22148049
63protein localization to chromosome, centromeric region (GO:0071459)3.21672758
64translational termination (GO:0006415)3.21487230
65viral transcription (GO:0019083)3.20028191
66DNA replication-independent nucleosome assembly (GO:0006336)3.19349158
67DNA replication-independent nucleosome organization (GO:0034724)3.19349158
68ribosome biogenesis (GO:0042254)3.17877590
69positive regulation of mitotic sister chromatid separation (GO:1901970)3.15974843
70positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.15974843
71positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.15974843
72pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.15726226
73CENP-A containing nucleosome assembly (GO:0034080)3.15118563
74regulation of chromosome segregation (GO:0051983)3.13931755
75regulation of mitotic metaphase/anaphase transition (GO:0030071)3.13314677
76regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.13314677
77negative regulation of chromosome segregation (GO:0051985)3.13307760
78regulation of mitotic sister chromatid separation (GO:0010965)3.13046812
79regulation of mitotic sister chromatid segregation (GO:0033047)3.13046812
80regulation of sister chromatid segregation (GO:0033045)3.13046812
81mitotic spindle assembly checkpoint (GO:0007094)3.12268234
82nucleotide-excision repair, DNA gap filling (GO:0006297)3.12009977
83negative regulation of mitotic sister chromatid segregation (GO:0033048)3.11129330
84negative regulation of mitotic sister chromatid separation (GO:2000816)3.11129330
85negative regulation of sister chromatid segregation (GO:0033046)3.11129330
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.11129330
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11129330
88DNA packaging (GO:0006323)3.10304307
89mitotic metaphase plate congression (GO:0007080)3.08651605
90telomere maintenance via telomere lengthening (GO:0010833)3.08555640
91dosage compensation (GO:0007549)3.08313399
92regulation of spindle organization (GO:0090224)3.08296953
93establishment of integrated proviral latency (GO:0075713)3.07574835
94chromatin assembly (GO:0031497)3.06304758
95mitotic spindle checkpoint (GO:0071174)3.06193039
96positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.04983257
97DNA topological change (GO:0006265)3.04750634
98protein localization to chromosome (GO:0034502)3.04695164
99translesion synthesis (GO:0019985)3.04482366
100protein K6-linked ubiquitination (GO:0085020)3.04427326
101meiotic nuclear division (GO:0007126)3.04161887
102metaphase plate congression (GO:0051310)3.03900213
103spindle assembly checkpoint (GO:0071173)3.03527917
104protein export from nucleus (GO:0006611)3.03266813
105negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.03261894
106pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.02497743
107UMP biosynthetic process (GO:0006222)3.02497743
108pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.02497743
109UMP metabolic process (GO:0046049)3.02497743
110synaptonemal complex organization (GO:0070193)3.01091533
111DNA conformation change (GO:0071103)3.00239300
112chromosome condensation (GO:0030261)3.00006523
113translational initiation (GO:0006413)2.98715730
114peptidyl-lysine dimethylation (GO:0018027)2.98223439
115chromatin assembly or disassembly (GO:0006333)2.97938894
116spindle checkpoint (GO:0031577)2.97208814
117regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.96051363
118translational elongation (GO:0006414)2.95174473
119histone H2B ubiquitination (GO:0033523)2.94967058
120positive regulation of cell cycle checkpoint (GO:1901978)2.93247355
121nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.93197375
122histone H4-K12 acetylation (GO:0043983)2.92192269
123pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.91643489
124SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.91640523
125meiosis I (GO:0007127)2.91288441
126ribonucleoprotein complex biogenesis (GO:0022613)2.90998870
127positive regulation of chromosome segregation (GO:0051984)2.89965669
128monoubiquitinated protein deubiquitination (GO:0035520)2.89432359
129regulation of mitotic spindle organization (GO:0060236)2.88966407
130pseudouridine synthesis (GO:0001522)2.88308112
131negative regulation of RNA splicing (GO:0033119)2.88165933
132regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.86884504
133postreplication repair (GO:0006301)2.86261768
134regulation of sister chromatid cohesion (GO:0007063)2.86224504
135regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.86206306
136kinetochore organization (GO:0051383)2.84517639
137histone H2A monoubiquitination (GO:0035518)2.83900659
138histone exchange (GO:0043486)2.83499005
139establishment of chromosome localization (GO:0051303)2.82994580
140mitotic chromosome condensation (GO:0007076)2.82757943
141cotranslational protein targeting to membrane (GO:0006613)2.82716132
142protein targeting to ER (GO:0045047)2.82555757
143ribosomal large subunit biogenesis (GO:0042273)2.82129315
144telomere organization (GO:0032200)2.82063667
145tetrahydrofolate metabolic process (GO:0046653)2.81650156
146regulation of centrosome cycle (GO:0046605)2.81200710
147piRNA metabolic process (GO:0034587)2.80188509
148telomere maintenance (GO:0000723)2.79182853
149cellular protein complex localization (GO:0034629)2.79041360
150negative regulation of mRNA metabolic process (GO:1903312)2.77708468
151somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.77545626
152isotype switching (GO:0045190)2.77545626
153somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.77545626
154mRNA cleavage (GO:0006379)2.77189390
155attachment of spindle microtubules to kinetochore (GO:0008608)2.76299953
156regulation of centrosome duplication (GO:0010824)2.76191457
157sister chromatid cohesion (GO:0007062)2.76066749
158nuclear envelope organization (GO:0006998)2.75163962
159non-recombinational repair (GO:0000726)2.74259143
160double-strand break repair via nonhomologous end joining (GO:0006303)2.74259143
161meiotic cell cycle process (GO:1903046)2.74108335
162paraxial mesoderm development (GO:0048339)2.73127641
163mRNA transport (GO:0051028)2.70360015
164chromosome organization (GO:0051276)2.70258263
165DNA methylation involved in gamete generation (GO:0043046)2.69811631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.71537928
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.24197750
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.52027066
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.25340046
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.06950247
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90476991
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79487331
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.76596545
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71390600
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39434052
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35351760
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.27173630
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.25677816
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21332155
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20475770
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13079420
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07591608
18MYC_22102868_ChIP-Seq_BL_Human2.07280870
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.03923717
20VDR_23849224_ChIP-Seq_CD4+_Human2.01386348
21MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97796547
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97476510
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.94938419
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94659000
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93020618
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.91081658
27XRN2_22483619_ChIP-Seq_HELA_Human1.90743160
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.89918305
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88775587
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86014462
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.84046930
32FOXP3_21729870_ChIP-Seq_TREG_Human1.83294656
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.83224679
34ZFX_18555785_ChIP-Seq_MESCs_Mouse1.81538015
35AR_21909140_ChIP-Seq_LNCAP_Human1.78942758
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75367010
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74855828
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74628516
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72644090
40CIITA_25753668_ChIP-Seq_RAJI_Human1.71204754
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70360107
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66086855
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.62877089
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62125932
45GABP_19822575_ChIP-Seq_HepG2_Human1.61081829
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59691034
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56681062
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54044675
49DCP1A_22483619_ChIP-Seq_HELA_Human1.53988342
50TTF2_22483619_ChIP-Seq_HELA_Human1.52810790
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.50380498
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48863137
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47063789
54KDM5A_27292631_Chip-Seq_BREAST_Human1.44382656
55ELK1_19687146_ChIP-ChIP_HELA_Human1.42928757
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.39165893
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37379733
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37364826
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37063822
60ZNF263_19887448_ChIP-Seq_K562_Human1.36722224
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36428536
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36428536
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36428536
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33667804
65CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32137448
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31360164
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28685755
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22824164
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22038733
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20735281
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20642820
72PKCTHETA_26484144_Chip-Seq_BREAST_Human1.18481880
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17756520
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17634312
75SCL_19346495_ChIP-Seq_HPC-7_Human1.16640910
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15433846
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12371873
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12307250
79TFEB_21752829_ChIP-Seq_HELA_Human1.11785468
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.11097190
81TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.09590278
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09243390
83NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08853457
84NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08009820
85FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06483780
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06214014
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06052524
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04637214
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04155039
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03852529
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02735846
92SOX17_20123909_ChIP-Seq_XEN_Mouse1.01388466
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00823719
94NANOG_21062744_ChIP-ChIP_HESCs_Human1.00223494
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99216352
96CLOCK_20551151_ChIP-Seq_293T_Human0.98519460
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95994451
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94581253
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94387735
100YY1_21170310_ChIP-Seq_MESCs_Mouse0.93602864
101SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93529299
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92044876
103ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91068425
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90097337
105MYC_18940864_ChIP-ChIP_HL60_Human0.89815128
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89767697
107GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89471477
108FUS_26573619_Chip-Seq_HEK293_Human0.89001683
109CHD1_26751641_Chip-Seq_LNCaP_Human0.88975034
110TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88279221
111TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88215249
112TP63_17297297_ChIP-ChIP_HaCaT_Human0.85877626
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85492149
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84643004
115NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.83482525
116FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81763341
117SPI1_23547873_ChIP-Seq_NB4_Human0.81684741
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80976855
119TCF7_22412390_ChIP-Seq_EML_Mouse0.80790091
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80440930
121EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.78165991
122GATA1_22025678_ChIP-Seq_K562_Human0.78153359
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77930870
124SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76770412
125SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76770412
126WT1_19549856_ChIP-ChIP_CCG9911_Human0.72646610
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.72624031

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.09759410
2MP0003693_abnormal_embryo_hatching4.04546232
3MP0008057_abnormal_DNA_replication3.91286333
4MP0004957_abnormal_blastocyst_morpholog3.85810939
5MP0003111_abnormal_nucleus_morphology3.38283187
6MP0008877_abnormal_DNA_methylation3.19522348
7MP0003077_abnormal_cell_cycle3.02937601
8MP0003806_abnormal_nucleotide_metabolis2.96963748
9MP0002877_abnormal_melanocyte_morpholog2.87922531
10MP0010352_gastrointestinal_tract_polyps2.86910151
11MP0004185_abnormal_adipocyte_glucose2.77158645
12MP0003123_paternal_imprinting2.77058055
13MP0002396_abnormal_hematopoietic_system2.67429274
14MP0008058_abnormal_DNA_repair2.61216657
15MP0010234_abnormal_vibrissa_follicle2.59273533
16MP0003705_abnormal_hypodermis_morpholog2.39024952
17MP0008007_abnormal_cellular_replicative2.30248838
18MP0001730_embryonic_growth_arrest2.20057905
19MP0000350_abnormal_cell_proliferation2.00122991
20MP0008932_abnormal_embryonic_tissue1.90985570
21MP0003121_genomic_imprinting1.89586912
22MP0001661_extended_life_span1.87531903
23MP0010307_abnormal_tumor_latency1.76401313
24MP0000490_abnormal_crypts_of1.75584116
25MP0004808_abnormal_hematopoietic_stem1.72506373
26MP0001697_abnormal_embryo_size1.72235714
27MP0010678_abnormal_skin_adnexa1.71186184
28MP0000383_abnormal_hair_follicle1.67463894
29MP0002138_abnormal_hepatobiliary_system1.66806155
30MP0002084_abnormal_developmental_patter1.66179450
31MP0003890_abnormal_embryonic-extraembry1.65101983
32MP0004233_abnormal_muscle_weight1.64786807
33MP0003567_abnormal_fetal_cardiomyocyte1.60862967
34MP0004197_abnormal_fetal_growth/weight/1.59717365
35MP0001672_abnormal_embryogenesis/_devel1.58683081
36MP0005380_embryogenesis_phenotype1.58683081
37MP0002086_abnormal_extraembryonic_tissu1.58175962
38MP0003787_abnormal_imprinting1.53796767
39MP0002080_prenatal_lethality1.51146103
40MP0005666_abnormal_adipose_tissue1.51065020
41MP0009379_abnormal_foot_pigmentation1.50955953
42MP0006054_spinal_hemorrhage1.50948050
43MP0003984_embryonic_growth_retardation1.49072182
44MP0003786_premature_aging1.48401788
45MP0005409_darkened_coat_color1.47388000
46MP0002085_abnormal_embryonic_tissue1.46748703
47MP0002088_abnormal_embryonic_growth/wei1.45833535
48MP0009697_abnormal_copulation1.42151630
49MP0001293_anophthalmia1.37831415
50MP0000313_abnormal_cell_death1.34070378
51MP0003937_abnormal_limbs/digits/tail_de1.31917058
52MP0002019_abnormal_tumor_incidence1.31718562
53MP0000733_abnormal_muscle_development1.30642909
54MP0000516_abnormal_urinary_system1.30495028
55MP0005367_renal/urinary_system_phenotyp1.30495028
56MP0003763_abnormal_thymus_physiology1.30194497
57MP0004133_heterotaxia1.27611095
58MP0009672_abnormal_birth_weight1.26714912
59MP0002210_abnormal_sex_determination1.26324555
60MP0001929_abnormal_gametogenesis1.22122125
61MP0001145_abnormal_male_reproductive1.21189779
62MP0003453_abnormal_keratinocyte_physiol1.21013837
63MP0002796_impaired_skin_barrier1.20830850
64MP0000428_abnormal_craniofacial_morphol1.20506387
65MP0009703_decreased_birth_body1.17980340
66MP0006292_abnormal_olfactory_placode1.16423401
67MP0003943_abnormal_hepatobiliary_system1.15830343
68MP0004264_abnormal_extraembryonic_tissu1.14770525
69MP0005076_abnormal_cell_differentiation1.11978722
70MP0000762_abnormal_tongue_morphology1.11101388
71MP0000653_abnormal_sex_gland1.10686845
72MP0003283_abnormal_digestive_organ1.09263210
73MP0002139_abnormal_hepatobiliary_system1.08978429
74MP0005220_abnormal_exocrine_pancreas1.08750582
75MP0000703_abnormal_thymus_morphology1.08213710
76MP0000569_abnormal_digit_pigmentation1.07905861
77MP0001545_abnormal_hematopoietic_system1.07607838
78MP0005397_hematopoietic_system_phenotyp1.07607838
79MP0002060_abnormal_skin_morphology1.07299038
80MP0000537_abnormal_urethra_morphology1.03717836
81MP0005174_abnormal_tail_pigmentation1.03126099
82MP0002697_abnormal_eye_size1.03080569
83MP0002398_abnormal_bone_marrow0.99577764
84MP0009053_abnormal_anal_canal0.97121137
85MP0003119_abnormal_digestive_system0.96501322
86MP0005501_abnormal_skin_physiology0.95134091
87MP0000678_abnormal_parathyroid_gland0.94587395
88MP0008995_early_reproductive_senescence0.93908099
89MP0005275_abnormal_skin_tensile0.93373859
90MP0001216_abnormal_epidermal_layer0.92465232
91MP0005075_abnormal_melanosome_morpholog0.91728168
92MP0004134_abnormal_chest_morphology0.91727209
93MP0000377_abnormal_hair_follicle0.91269666
94MP0003315_abnormal_perineum_morphology0.90914097
95MP0005375_adipose_tissue_phenotype0.90495616
96MP0000427_abnormal_hair_cycle0.90201580
97MP0000579_abnormal_nail_morphology0.90092202
98MP0002166_altered_tumor_susceptibility0.89416443
99MP0002722_abnormal_immune_system0.88618461
100MP0000432_abnormal_head_morphology0.88584051
101MP0002075_abnormal_coat/hair_pigmentati0.87983908
102MP0001944_abnormal_pancreas_morphology0.87394299
103MP0002269_muscular_atrophy0.87301585
104MP0003115_abnormal_respiratory_system0.86952735
105MP0001915_intracranial_hemorrhage0.85572548
106MP0006035_abnormal_mitochondrial_morpho0.84987650
107MP0005623_abnormal_meninges_morphology0.84980369
108MP0000689_abnormal_spleen_morphology0.84813865
109MP0002114_abnormal_axial_skeleton0.83387201
110MP0000358_abnormal_cell_content/0.83030194
111MP0003186_abnormal_redox_activity0.83020709
112MP0000627_abnormal_mammary_gland0.82899336
113MP0003868_abnormal_feces_composition0.81630122
114MP0003935_abnormal_craniofacial_develop0.81506633
115MP0002095_abnormal_skin_pigmentation0.80649878
116MP0002928_abnormal_bile_duct0.80488666
117MP0004087_abnormal_muscle_fiber0.80049165
118MP0002009_preneoplasia0.79683897
119MP0010630_abnormal_cardiac_muscle0.79247029
120MP0000759_abnormal_skeletal_muscle0.77938194
121MP0000477_abnormal_intestine_morphology0.77393981
122MP0000566_synostosis0.76429583
123MP0005384_cellular_phenotype0.75027415
124MP0002160_abnormal_reproductive_system0.73894882
125MP0002006_tumorigenesis0.73296813
126MP0000013_abnormal_adipose_tissue0.72836074
127MP0009250_abnormal_appendicular_skeleto0.72250998
128MP0002092_abnormal_eye_morphology0.70790822
129MP0003385_abnormal_body_wall0.70495890
130MP0003942_abnormal_urinary_system0.70194732
131MP0003941_abnormal_skin_development0.70104836
132MP0002693_abnormal_pancreas_physiology0.69262302
133MP0006036_abnormal_mitochondrial_physio0.68233333
134MP0005085_abnormal_gallbladder_physiolo0.68070443
135MP0003698_abnormal_male_reproductive0.67475801
136MP0002429_abnormal_blood_cell0.67304919
137MP0001119_abnormal_female_reproductive0.66958706
138MP0003718_maternal_effect0.66819145
139MP0001186_pigmentation_phenotype0.66571169
140MP0006072_abnormal_retinal_apoptosis0.64734522
141MP0001286_abnormal_eye_development0.62462141
142MP0005621_abnormal_cell_physiology0.60295925
143MP0005389_reproductive_system_phenotype0.59005332
144MP0005266_abnormal_metabolism0.58989560
145MP0000598_abnormal_liver_morphology0.58948991
146MP0000613_abnormal_salivary_gland0.58169748

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.40322254
2Ependymoma (HP:0002888)4.80373864
3Aplastic anemia (HP:0001915)4.33482497
4Medulloblastoma (HP:0002885)4.22941970
5Colon cancer (HP:0003003)4.10770985
6Rhabdomyosarcoma (HP:0002859)3.79388747
7Volvulus (HP:0002580)3.57132069
8Neoplasm of the oral cavity (HP:0100649)3.30368508
9Biliary tract neoplasm (HP:0100574)3.30286654
10Basal cell carcinoma (HP:0002671)3.28219048
11Breast hypoplasia (HP:0003187)3.27761015
12Reticulocytopenia (HP:0001896)3.21858497
13Abnormality of the astrocytes (HP:0100707)3.12825991
14Astrocytoma (HP:0009592)3.12825991
15IgM deficiency (HP:0002850)3.11517067
16Nephroblastoma (Wilms tumor) (HP:0002667)3.10638354
17Papillary thyroid carcinoma (HP:0002895)3.10560006
18Abnormality of chromosome stability (HP:0003220)3.10329587
19Agnosia (HP:0010524)3.08061480
2011 pairs of ribs (HP:0000878)3.07515248
21Supernumerary spleens (HP:0009799)3.04844203
22Abnormality of cells of the erythroid lineage (HP:0012130)3.03035191
23Embryonal renal neoplasm (HP:0011794)2.93291184
24Overlapping toe (HP:0001845)2.85780482
25Neoplasm of striated muscle (HP:0009728)2.84413867
26Abnormal number of erythroid precursors (HP:0012131)2.83178749
27Glioma (HP:0009733)2.77592871
28Abnormal biliary tract morphology (HP:0012440)2.77455257
29Degeneration of anterior horn cells (HP:0002398)2.75116670
30Abnormality of the anterior horn cell (HP:0006802)2.75116670
31Neoplasm of the rectum (HP:0100743)2.74536248
32Deep philtrum (HP:0002002)2.74081738
33Amaurosis fugax (HP:0100576)2.73206479
34Myelodysplasia (HP:0002863)2.71278356
35Missing ribs (HP:0000921)2.68012300
36Limb hypertonia (HP:0002509)2.61921881
37Neoplasm of the small intestine (HP:0100833)2.57764559
38Abnormality of the calcaneus (HP:0008364)2.55984362
39Selective tooth agenesis (HP:0001592)2.55320178
40Prominent nose (HP:0000448)2.50787771
41Progressive external ophthalmoplegia (HP:0000590)2.49317654
42Angiofibromas (HP:0010615)2.47068182
43Adenoma sebaceum (HP:0009720)2.47068182
44Squamous cell carcinoma (HP:0002860)2.46913356
45Abnormality of the left ventricular outflow tract (HP:0011103)2.43817962
46Subaortic stenosis (HP:0001682)2.43817962
47Oral leukoplakia (HP:0002745)2.40650240
48Dysmetric saccades (HP:0000641)2.40268284
49Neonatal hypoglycemia (HP:0001998)2.39230810
50Microglossia (HP:0000171)2.38659480
51Macroorchidism (HP:0000053)2.38206714
52Chromsome breakage (HP:0040012)2.36778530
53Ankyloglossia (HP:0010296)2.36675452
54Acute myeloid leukemia (HP:0004808)2.35017348
55Horizontal nystagmus (HP:0000666)2.34044756
56Sandal gap (HP:0001852)2.33887747
57Neoplasm of the colon (HP:0100273)2.32040144
58Gonadotropin excess (HP:0000837)2.31529911
59Shoulder girdle muscle weakness (HP:0003547)2.30692532
60Capillary hemangiomas (HP:0005306)2.30294647
61Absent thumb (HP:0009777)2.29521290
62Asymmetry of the thorax (HP:0001555)2.28412259
63Ovarian neoplasm (HP:0100615)2.27974549
64Thrombocytosis (HP:0001894)2.27177514
65Cafe-au-lait spot (HP:0000957)2.26905796
66Abnormality of the labia minora (HP:0012880)2.24616828
67Truncal obesity (HP:0001956)2.23889710
68Abnormal spermatogenesis (HP:0008669)2.22107977
69Neoplasm of the pancreas (HP:0002894)2.20049169
70Abnormality of the lower motor neuron (HP:0002366)2.19501677
71Abnormality of chromosome segregation (HP:0002916)2.18915273
72Asplenia (HP:0001746)2.18413603
73Lymphoma (HP:0002665)2.15554482
74High pitched voice (HP:0001620)2.15197102
75Stenosis of the external auditory canal (HP:0000402)2.14734769
76Progressive muscle weakness (HP:0003323)2.11368249
77Proximal placement of thumb (HP:0009623)2.11177085
78Vertebral arch anomaly (HP:0008438)2.09647617
79Abnormality of the preputium (HP:0100587)2.09442306
80Patellar aplasia (HP:0006443)2.08754062
81Atresia of the external auditory canal (HP:0000413)2.08737636
82Calcaneovalgus deformity (HP:0001848)2.07844068
83Abnormality of the fingertips (HP:0001211)2.07168556
84Premature graying of hair (HP:0002216)2.05732925
85Bone marrow hypocellularity (HP:0005528)2.05064673
86Abnormal number of incisors (HP:0011064)2.04963252
87Abnormality of the distal phalanx of the thumb (HP:0009617)2.04126095
88Thyroid carcinoma (HP:0002890)2.03683097
89Broad palm (HP:0001169)2.03327202
90Multiple enchondromatosis (HP:0005701)2.03080475
91Breast carcinoma (HP:0003002)2.03061495
92Deviation of the thumb (HP:0009603)2.00549917
93Aplasia/Hypoplasia of the sternum (HP:0006714)1.99640723
94Microvesicular hepatic steatosis (HP:0001414)1.99031420
95Microretrognathia (HP:0000308)1.97397214
96Diastasis recti (HP:0001540)1.97162671
97Pallor (HP:0000980)1.96478174
98Impulsivity (HP:0100710)1.96384555
99Abnormality of lateral ventricle (HP:0030047)1.95849817
100Pancytopenia (HP:0001876)1.95714961
101Low anterior hairline (HP:0000294)1.94830469
102Carpal bone hypoplasia (HP:0001498)1.92605193
103Intestinal polyposis (HP:0200008)1.91955077
104Intestinal polyp (HP:0005266)1.91924902
105Aplasia/Hypoplasia of the uvula (HP:0010293)1.91623562
106Relative macrocephaly (HP:0004482)1.90926897
107Aplasia/Hypoplasia of the spleen (HP:0010451)1.90849419
108Increased nuchal translucency (HP:0010880)1.90817320
109Meckel diverticulum (HP:0002245)1.90189369
110Abnormality of the phalanges of the hallux (HP:0010057)1.90030014
111Slender long bone (HP:0003100)1.89271669
112Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89259707
113Short middle phalanx of the 5th finger (HP:0004220)1.88532400
114Aplasia/Hypoplasia of the patella (HP:0006498)1.87241358
115Menstrual irregularities (HP:0000858)1.85073851
116Acute lymphatic leukemia (HP:0006721)1.83079428
117Sloping forehead (HP:0000340)1.82894299
118Macrocytic anemia (HP:0001972)1.82655171
119Heterotopia (HP:0002282)1.82460740
120Recurrent bronchitis (HP:0002837)1.82097510
121Neoplasm of the thyroid gland (HP:0100031)1.81454301
122Embryonal neoplasm (HP:0002898)1.80271125
123Duodenal stenosis (HP:0100867)1.80173081
124Small intestinal stenosis (HP:0012848)1.80173081
125Termporal pattern (HP:0011008)1.79588075
126Insidious onset (HP:0003587)1.79588075
127Facial cleft (HP:0002006)1.79306133
128Facial hemangioma (HP:0000329)1.78886428
129Syringomyelia (HP:0003396)1.78752695
130Spinal cord lesions (HP:0100561)1.78752695
131Abnormality of cochlea (HP:0000375)1.78617015
132Deep palmar crease (HP:0006191)1.77949790
133Cubitus valgus (HP:0002967)1.77802231
134Abnormality of the duodenum (HP:0002246)1.76080747
135Lip pit (HP:0100267)1.75578810
136Poikiloderma (HP:0001029)1.74716159
137Rimmed vacuoles (HP:0003805)1.74595834
138Intrahepatic cholestasis (HP:0001406)1.74429250
139Posterior subcapsular cataract (HP:0007787)1.74146261
140Uterine neoplasm (HP:0010784)1.73962596
141Abnormality of monocarboxylic acid metabolism (HP:0010996)1.73918159
142Hypochromic microcytic anemia (HP:0004840)1.73898919
143Abnormality of the ileum (HP:0001549)1.73867458
144Ectopic kidney (HP:0000086)1.73599544
145Rough bone trabeculation (HP:0100670)1.73245336
146Large hands (HP:0001176)1.72609431
147Narrow palate (HP:0000189)1.72600514
148Premature ovarian failure (HP:0008209)1.72283771
149Obsessive-compulsive behavior (HP:0000722)1.72196538
150Gastrointestinal carcinoma (HP:0002672)1.71480944
151Dislocated radial head (HP:0003083)1.70925277
152Abnormal lung lobation (HP:0002101)1.67525480
153Long eyelashes (HP:0000527)1.67452181
154Septate vagina (HP:0001153)1.67445669
155Deformed tarsal bones (HP:0008119)1.67258014
156Hypoplastic labia majora (HP:0000059)1.65694709
157Nemaline bodies (HP:0003798)1.65109415
158Cutaneous melanoma (HP:0012056)1.63501902
159Choanal atresia (HP:0000453)1.61750617
160Sparse lateral eyebrow (HP:0005338)1.61750523
161Malignant gastrointestinal tract tumors (HP:0006749)1.59892379
162Rhizomelia (HP:0008905)1.59557294
163Low posterior hairline (HP:0002162)1.59248961
164Abnormality of oral frenula (HP:0000190)1.59077471
165Cystic hygroma (HP:0000476)1.58831289
166Broad distal phalanx of finger (HP:0009836)1.56778591
167Flat acetabular roof (HP:0003180)1.55815846
168Exercise-induced myalgia (HP:0003738)1.55584263
169Abnormality of the labia majora (HP:0012881)1.54472662
170Muscle fiber inclusion bodies (HP:0100299)1.54295046
171Abnormality of the parietal bone (HP:0002696)1.52643534
172Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.52458535

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.38522533
2WEE13.80478892
3PASK3.34627063
4FLT33.23904693
5ACVR1B3.10480552
6PKN23.06960366
7NEK22.57783118
8CAMK1G2.48797665
9EEF2K2.43965101
10MKNK12.40960754
11SRPK12.40289089
12TTK2.36663829
13CDK122.34100123
14RPS6KB22.04947113
15BRSK21.99402737
16BRD41.97371581
17NEK11.94586288
18MKNK21.93869271
19SCYL21.86515569
20STK31.86257057
21FRK1.77686011
22STK161.74580647
23TAF11.70070452
24STK38L1.63644604
25ATR1.59179656
26CDK71.57171351
27TGFBR11.54131356
28CDK41.52990957
29PLK11.49353301
30TLK11.46283758
31SMG11.42899439
32PDGFRA1.40430970
33MAP3K91.39327134
34BUB11.34084492
35DYRK31.32066502
36MAP3K81.28201423
37EIF2AK31.25335123
38CDK61.25300629
39CHEK11.24796213
40MST1R1.24700143
41MAP3K101.22809864
42PBK1.22252982
43CDK191.20949314
44AURKB1.20356397
45CHEK21.19756466
46KSR21.15605693
47MAP3K21.15226382
48EPHA21.13249789
49ALK1.12423744
50STK241.11940998
51EIF2AK11.11688851
52PLK41.10528230
53VRK11.09203383
54ICK1.07686142
55ATM1.04728363
56MAPKAPK31.01338040
57STK101.00104935
58PLK30.99691234
59PDGFRB0.99608948
60BMX0.98439941
61LRRK20.97871451
62TSSK60.97752528
63PRPF4B0.97301503
64CDK20.91911825
65JAK30.89720784
66LATS20.89125599
67HIPK20.86247921
68WNK10.83431072
69STK40.83152087
70RET0.82773752
71BCKDK0.81907536
72TRIB30.78784804
73RPS6KA40.78681903
74PAK40.78515686
75CDK30.78442528
76MAP2K30.78286824
77TTN0.77848332
78KIT0.77632770
79MAP4K10.76306426
80PIM10.74040055
81DMPK0.73670710
82IRAK30.73585742
83AKT30.70706528
84PNCK0.70433464
85CSNK2A20.68078447
86PTK20.67864921
87CAMK1D0.67775728
88NME20.67014730
89KSR10.65257581
90ILK0.64746979
91CDK90.63371467
92EIF2AK20.62334614
93PDK40.61717731
94PDK30.61717731
95AURKA0.61290817
96MTOR0.60717816
97NLK0.60680955
98FGFR10.59214510
99CDK10.58496295
100BRSK10.57436929
101MET0.57228693
102BTK0.56917820
103OBSCN0.56129515
104TEC0.55660795
105LATS10.55244829
106NEK60.54762128
107PRKCI0.54490724
108PDK20.54353071
109MAP3K130.52082002
110PTK60.51151753
111FGFR30.50340151
112TRPM70.50339697
113MELK0.50121315
114CSNK2A10.48321281
115ZAK0.48306180
116SIK10.46957735
117MAP3K60.46301789
118CSNK1E0.45701741
119CSNK1D0.42603208
120CSF1R0.42299797
121RAF10.42084019
122CSNK1G10.41843583
123MAPK140.41790410
124DAPK10.41541277
125SGK30.41350406
126CSNK1G30.40515073
127ERBB30.40010612
128MAP3K120.39253719
129TESK20.38779680
130AKT20.37960528
131PRKDC0.37819235
132RPS6KB10.36807566
133GRK60.35549051
134ZAP700.35351281
135MAPK110.33221127
136MAPK10.30732344
137NEK90.30015429
138MAP2K60.29562656
139BRAF0.29512163
140PAK20.28398895
141AKT10.26533331

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.79920325
2Mismatch repair_Homo sapiens_hsa034304.75689092
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37401298
4One carbon pool by folate_Homo sapiens_hsa006703.35205389
5RNA transport_Homo sapiens_hsa030133.05176778
6Spliceosome_Homo sapiens_hsa030402.98583894
7Homologous recombination_Homo sapiens_hsa034402.94868104
8Cell cycle_Homo sapiens_hsa041102.84053351
9Base excision repair_Homo sapiens_hsa034102.82193462
10Nucleotide excision repair_Homo sapiens_hsa034202.74278218
11Ribosome_Homo sapiens_hsa030102.72333118
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.55469421
13Selenocompound metabolism_Homo sapiens_hsa004502.43587527
14Non-homologous end-joining_Homo sapiens_hsa034502.32465287
15RNA polymerase_Homo sapiens_hsa030202.24607973
16RNA degradation_Homo sapiens_hsa030182.15244538
17Fanconi anemia pathway_Homo sapiens_hsa034602.08454764
18Maturity onset diabetes of the young_Homo sapiens_hsa049502.05775867
19Pyrimidine metabolism_Homo sapiens_hsa002402.04757626
20mRNA surveillance pathway_Homo sapiens_hsa030152.04727120
21Basal transcription factors_Homo sapiens_hsa030221.79738347
22Protein export_Homo sapiens_hsa030601.63423982
23Thyroid cancer_Homo sapiens_hsa052161.50475444
24p53 signaling pathway_Homo sapiens_hsa041151.42555216
25Adherens junction_Homo sapiens_hsa045201.39135610
26Proteasome_Homo sapiens_hsa030501.26216081
27Renal cell carcinoma_Homo sapiens_hsa052111.18707750
28Oocyte meiosis_Homo sapiens_hsa041141.18609463
29Glioma_Homo sapiens_hsa052141.15733596
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13158046
31Systemic lupus erythematosus_Homo sapiens_hsa053221.09515603
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.09187028
33ErbB signaling pathway_Homo sapiens_hsa040121.06636415
34Viral carcinogenesis_Homo sapiens_hsa052031.04902220
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.03635035
36Purine metabolism_Homo sapiens_hsa002301.03441653
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03341161
38Antigen processing and presentation_Homo sapiens_hsa046121.02116340
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00607115
40N-Glycan biosynthesis_Homo sapiens_hsa005100.95120758
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94943633
42Melanoma_Homo sapiens_hsa052180.90104275
43Vitamin B6 metabolism_Homo sapiens_hsa007500.86231424
44Proteoglycans in cancer_Homo sapiens_hsa052050.84769798
45VEGF signaling pathway_Homo sapiens_hsa043700.84117790
46Folate biosynthesis_Homo sapiens_hsa007900.83606388
47Pentose phosphate pathway_Homo sapiens_hsa000300.82430570
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79866103
49Choline metabolism in cancer_Homo sapiens_hsa052310.77794281
50Herpes simplex infection_Homo sapiens_hsa051680.77024720
51Epstein-Barr virus infection_Homo sapiens_hsa051690.73473898
52Biosynthesis of amino acids_Homo sapiens_hsa012300.72789398
53HTLV-I infection_Homo sapiens_hsa051660.71466071
54Propanoate metabolism_Homo sapiens_hsa006400.68679951
55Focal adhesion_Homo sapiens_hsa045100.64352788
56Primary immunodeficiency_Homo sapiens_hsa053400.62824795
57Lysine degradation_Homo sapiens_hsa003100.60800539
58Colorectal cancer_Homo sapiens_hsa052100.59588245
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59231060
60MicroRNAs in cancer_Homo sapiens_hsa052060.57352093
61Sulfur relay system_Homo sapiens_hsa041220.56693182
62Circadian rhythm_Homo sapiens_hsa047100.56665277
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56489483
64Inositol phosphate metabolism_Homo sapiens_hsa005620.56415608
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.54195325
66Alcoholism_Homo sapiens_hsa050340.53735539
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53708360
68Hedgehog signaling pathway_Homo sapiens_hsa043400.53125877
69Acute myeloid leukemia_Homo sapiens_hsa052210.52636633
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52175332
71Fatty acid biosynthesis_Homo sapiens_hsa000610.51983855
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50933608
73Tight junction_Homo sapiens_hsa045300.50205978
74Long-term potentiation_Homo sapiens_hsa047200.49381466
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48787329
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48619773
77Insulin resistance_Homo sapiens_hsa049310.48285598
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.47286890
79Small cell lung cancer_Homo sapiens_hsa052220.46636801
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.42770946
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42282496
82Chronic myeloid leukemia_Homo sapiens_hsa052200.41719139
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41018465
84Carbon metabolism_Homo sapiens_hsa012000.38487178
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38322654
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36930147
87Non-small cell lung cancer_Homo sapiens_hsa052230.34873856
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.34161002
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34124041
90Dorso-ventral axis formation_Homo sapiens_hsa043200.33096437
91TGF-beta signaling pathway_Homo sapiens_hsa043500.31994881
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31903082
93mTOR signaling pathway_Homo sapiens_hsa041500.30982610
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30043009
95T cell receptor signaling pathway_Homo sapiens_hsa046600.29551481
96Glucagon signaling pathway_Homo sapiens_hsa049220.29214107
97Linoleic acid metabolism_Homo sapiens_hsa005910.28041750
98Bladder cancer_Homo sapiens_hsa052190.27122156
99Hippo signaling pathway_Homo sapiens_hsa043900.26540746
100Prostate cancer_Homo sapiens_hsa052150.25069619
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23422686
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23309629
103Hepatitis B_Homo sapiens_hsa051610.22482737
104Wnt signaling pathway_Homo sapiens_hsa043100.22086079
105Pathways in cancer_Homo sapiens_hsa052000.21598098
106Endometrial cancer_Homo sapiens_hsa052130.21139597
107AMPK signaling pathway_Homo sapiens_hsa041520.20865705
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20538386
109Glutathione metabolism_Homo sapiens_hsa004800.20117110
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19291136
111Notch signaling pathway_Homo sapiens_hsa043300.18903192
112Caffeine metabolism_Homo sapiens_hsa002320.18135920
113Galactose metabolism_Homo sapiens_hsa000520.18078800
114Pancreatic cancer_Homo sapiens_hsa052120.15684706
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15659314
116B cell receptor signaling pathway_Homo sapiens_hsa046620.14934217
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14819356
118Basal cell carcinoma_Homo sapiens_hsa052170.11766079
119FoxO signaling pathway_Homo sapiens_hsa040680.10976147
120Platelet activation_Homo sapiens_hsa046110.10525801
121Pyruvate metabolism_Homo sapiens_hsa006200.10168179
122Insulin signaling pathway_Homo sapiens_hsa049100.10059080
123Prolactin signaling pathway_Homo sapiens_hsa049170.10047006
124Metabolic pathways_Homo sapiens_hsa011000.08747482
125Measles_Homo sapiens_hsa051620.08392766
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.07575405
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07486003
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.07445908

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