UROD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* protoporphyrinogen IX metabolic process (GO:0046501)9.32736146
2* protoporphyrinogen IX biosynthetic process (GO:0006782)8.91188061
3* heme biosynthetic process (GO:0006783)6.77128086
4* porphyrin-containing compound biosynthetic process (GO:0006779)6.40523081
5* heme metabolic process (GO:0042168)5.85024501
6* tetrapyrrole biosynthetic process (GO:0033014)5.81038730
7* porphyrin-containing compound metabolic process (GO:0006778)5.54800530
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.81277704
9L-phenylalanine metabolic process (GO:0006558)4.81277704
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.73208651
11L-phenylalanine catabolic process (GO:0006559)4.73208651
12deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.71988738
13cysteine metabolic process (GO:0006534)4.27619268
14telomere maintenance via semi-conservative replication (GO:0032201)4.18725232
15DNA strand elongation involved in DNA replication (GO:0006271)4.13956120
16lysine metabolic process (GO:0006553)4.10652306
17lysine catabolic process (GO:0006554)4.10652306
18oxygen transport (GO:0015671)4.08609052
19chaperone-mediated protein transport (GO:0072321)4.04338938
20aromatic amino acid family catabolic process (GO:0009074)4.03260971
21DNA strand elongation (GO:0022616)4.01598309
22gas transport (GO:0015669)3.93830164
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.90646570
24glyoxylate metabolic process (GO:0046487)3.90379370
25regulation of mitochondrial translation (GO:0070129)3.90165201
26heme transport (GO:0015886)3.86587007
27respiratory electron transport chain (GO:0022904)3.82527751
28* tetrapyrrole metabolic process (GO:0033013)3.81814593
29glycine metabolic process (GO:0006544)3.74122264
30electron transport chain (GO:0022900)3.70776399
31pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.69267421
32serine family amino acid biosynthetic process (GO:0009070)3.68382604
33pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.67675376
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.66807044
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66085906
36pseudouridine synthesis (GO:0001522)3.62467509
37negative regulation of ligase activity (GO:0051352)3.62162624
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.62162624
39serine family amino acid metabolic process (GO:0009069)3.61530222
40anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.60416833
41mitochondrial respiratory chain complex assembly (GO:0033108)3.57644259
42protein complex biogenesis (GO:0070271)3.57605668
43ethanol oxidation (GO:0006069)3.56569165
44very-low-density lipoprotein particle assembly (GO:0034379)3.55937726
45hemoglobin metabolic process (GO:0020027)3.54880857
46purine nucleobase biosynthetic process (GO:0009113)3.54239232
47triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.53562534
48* pigment biosynthetic process (GO:0046148)3.53219835
49protein targeting to mitochondrion (GO:0006626)3.52436549
50formation of translation preinitiation complex (GO:0001731)3.52321068
51indolalkylamine catabolic process (GO:0046218)3.51744128
52tryptophan catabolic process (GO:0006569)3.51744128
53indole-containing compound catabolic process (GO:0042436)3.51744128
54proteasome assembly (GO:0043248)3.49948439
55mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.48899948
56mitochondrial respiratory chain complex I assembly (GO:0032981)3.48899948
57NADH dehydrogenase complex assembly (GO:0010257)3.48899948
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.48672051
59ribosomal large subunit biogenesis (GO:0042273)3.48564750
60telomere maintenance via recombination (GO:0000722)3.48152324
61deoxyribose phosphate biosynthetic process (GO:0046385)3.43089960
622-deoxyribonucleotide biosynthetic process (GO:0009265)3.43089960
63kynurenine metabolic process (GO:0070189)3.42695657
64response to methylmercury (GO:0051597)3.42299022
65bile acid biosynthetic process (GO:0006699)3.41735377
66tryptophan metabolic process (GO:0006568)3.40648451
67response to lead ion (GO:0010288)3.40387581
68positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.39281851
69erythrocyte maturation (GO:0043249)3.38046863
70aldehyde catabolic process (GO:0046185)3.36140539
71serine family amino acid catabolic process (GO:0009071)3.35608485
72ribosomal small subunit biogenesis (GO:0042274)3.35333128
73cofactor catabolic process (GO:0051187)3.34614110
74aerobic respiration (GO:0009060)3.34605312
75nucleobase biosynthetic process (GO:0046112)3.31929013
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.31723565
77DNA replication initiation (GO:0006270)3.30775329
78mitotic recombination (GO:0006312)3.28837952
79regulation of cellular amino acid metabolic process (GO:0006521)3.28474404
80sulfur amino acid catabolic process (GO:0000098)3.27835461
81establishment of protein localization to mitochondrial membrane (GO:0090151)3.27557698
82aspartate family amino acid catabolic process (GO:0009068)3.27512954
83intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27271846
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27271846
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.27139645
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.27139645
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.27139645
88* pigment metabolic process (GO:0042440)3.27104131
89rRNA modification (GO:0000154)3.26875711
90positive regulation of ligase activity (GO:0051351)3.25969798
91folic acid metabolic process (GO:0046655)3.24951801
92* cofactor biosynthetic process (GO:0051188)3.23788978
93signal transduction involved in DNA damage checkpoint (GO:0072422)3.23271658
94signal transduction involved in DNA integrity checkpoint (GO:0072401)3.23271658
95fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.22950245
96L-serine metabolic process (GO:0006563)3.22358825
97viral transcription (GO:0019083)3.21878090
98plasma lipoprotein particle assembly (GO:0034377)3.20867684
99response to insecticide (GO:0017085)3.19486231
100establishment of protein localization to mitochondrion (GO:0072655)3.19304340
101nucleobase-containing small molecule interconversion (GO:0015949)3.17431675
102energy coupled proton transport, down electrochemical gradient (GO:0015985)3.16960435
103ATP synthesis coupled proton transport (GO:0015986)3.16960435
104amino acid salvage (GO:0043102)3.16921432
105L-methionine salvage (GO:0071267)3.16921432
106L-methionine biosynthetic process (GO:0071265)3.16921432
107IMP biosynthetic process (GO:0006188)3.15801622
108alpha-amino acid catabolic process (GO:1901606)3.15590651
109signal transduction involved in cell cycle checkpoint (GO:0072395)3.15102639
110maturation of SSU-rRNA (GO:0030490)3.14459086
111establishment of integrated proviral latency (GO:0075713)3.13770921
112alpha-linolenic acid metabolic process (GO:0036109)3.13515555
113aromatic amino acid family metabolic process (GO:0009072)3.13256196
114branched-chain amino acid catabolic process (GO:0009083)3.12653182
115translational termination (GO:0006415)3.12560433
116ribonucleoprotein complex biogenesis (GO:0022613)3.12179207
117high-density lipoprotein particle remodeling (GO:0034375)3.12146225
118amino-acid betaine metabolic process (GO:0006577)3.10881106
119cellular component biogenesis (GO:0044085)3.10275417
120ATP biosynthetic process (GO:0006754)3.10167479
121DNA topological change (GO:0006265)3.10121108
122negative regulation of fibrinolysis (GO:0051918)3.09848734
123protein localization to mitochondrion (GO:0070585)3.09641616
124maturation of 5.8S rRNA (GO:0000460)3.08715218
125regulation of ubiquitin-protein transferase activity (GO:0051438)3.07717851
126ribosome assembly (GO:0042255)3.07686106
127sulfur amino acid biosynthetic process (GO:0000097)3.06011255
128ribosomal small subunit assembly (GO:0000028)3.04245797
129protein deneddylation (GO:0000338)3.03698435
130deoxyribonucleotide biosynthetic process (GO:0009263)3.03647575
131oxidative phosphorylation (GO:0006119)3.02514957
132protein maturation by protein folding (GO:0022417)3.02398058
133regulation of fibrinolysis (GO:0051917)3.01667889
134water-soluble vitamin biosynthetic process (GO:0042364)3.01363676
135transcription-coupled nucleotide-excision repair (GO:0006283)3.00003871
136purine nucleoside monophosphate biosynthetic process (GO:0009127)2.99570524
137purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.99570524
138ribosome biogenesis (GO:0042254)2.99426786
139SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.99044803
140CENP-A containing nucleosome assembly (GO:0034080)2.98779131
141purine nucleoside triphosphate biosynthetic process (GO:0009145)2.98391194
142cellular ketone body metabolic process (GO:0046950)2.98251442
143protein-cofactor linkage (GO:0018065)2.98239182
144regulation of ligase activity (GO:0051340)2.97871339
145purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.97701342
146cullin deneddylation (GO:0010388)2.96919945
147translation (GO:0006412)2.96531493
148kinetochore assembly (GO:0051382)2.96282841
149blood coagulation, intrinsic pathway (GO:0007597)2.95551969
150guanosine-containing compound biosynthetic process (GO:1901070)2.95080834
151cellular amino acid catabolic process (GO:0009063)2.94219540
152deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.93737440
153cotranslational protein targeting to membrane (GO:0006613)2.93577966
154respiratory chain complex IV assembly (GO:0008535)2.92659816
155response to nitrosative stress (GO:0051409)2.90917725
156L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.90503839
157DNA deamination (GO:0045006)2.89988620
158homocysteine metabolic process (GO:0050667)2.88218459
159regulation of triglyceride catabolic process (GO:0010896)2.88195247
160regulation of protein activation cascade (GO:2000257)2.86459681
161S-adenosylmethionine metabolic process (GO:0046500)2.85477924
162pteridine-containing compound biosynthetic process (GO:0042559)2.84063989
163aspartate family amino acid metabolic process (GO:0009066)2.81141893
164imidazole-containing compound metabolic process (GO:0052803)2.80992618
165short-chain fatty acid metabolic process (GO:0046459)2.80864087
166* cofactor metabolic process (GO:0051186)2.80804238
167methionine biosynthetic process (GO:0009086)2.80259949
168tyrosine metabolic process (GO:0006570)2.79569833
169sulfur amino acid metabolic process (GO:0000096)2.79561153
170methionine metabolic process (GO:0006555)2.77387695
171tetrahydrofolate metabolic process (GO:0046653)2.76575495
172bile acid metabolic process (GO:0008206)2.76416752
173urea cycle (GO:0000050)2.73877293
174urea metabolic process (GO:0019627)2.73877293
175mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.72223809
176organic acid catabolic process (GO:0016054)2.71953414
177carboxylic acid catabolic process (GO:0046395)2.71953414
178fatty acid beta-oxidation (GO:0006635)2.71906403
179regulation of cholesterol esterification (GO:0010872)2.71897393
180coenzyme catabolic process (GO:0009109)2.71300002
181DNA replication checkpoint (GO:0000076)2.70908766
182branched-chain amino acid metabolic process (GO:0009081)2.70696231
183cellular biogenic amine catabolic process (GO:0042402)2.69583599
184amine catabolic process (GO:0009310)2.69583599

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.32234914
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.83777862
3E2F7_22180533_ChIP-Seq_HELA_Human4.66147661
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.58329841
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.27999845
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.25090414
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.22745126
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.17371352
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.10742833
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08488733
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.00929426
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.93715585
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88541175
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.80266410
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79463706
16* ETS1_20019798_ChIP-Seq_JURKAT_Human2.73957091
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.71591255
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.63759032
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56435617
20GATA1_22025678_ChIP-Seq_K562_Human2.41490366
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.28101029
22* SRF_21415370_ChIP-Seq_HL-1_Mouse2.24949254
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23358317
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18137848
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16107034
26* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12969551
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.12739528
28LXR_22158963_ChIP-Seq_LIVER_Mouse2.10970862
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06559636
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04541845
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03471774
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97139666
33DCP1A_22483619_ChIP-Seq_HELA_Human1.92792583
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.91778200
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.90776154
36VDR_23849224_ChIP-Seq_CD4+_Human1.86947825
37XRN2_22483619_ChIP-Seq_HELA_Human1.83567948
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79573911
39* FOXP3_21729870_ChIP-Seq_TREG_Human1.78245080
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73805656
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.63858158
42GABP_19822575_ChIP-Seq_HepG2_Human1.62724850
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58528493
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.57626825
45AR_21909140_ChIP-Seq_LNCAP_Human1.54731203
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51510087
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45980982
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45783899
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43577175
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.42388283
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41216392
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41134837
53* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37948483
54* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36996103
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36985123
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34180900
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28044273
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27647227
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27603115
60* GATA1_19941826_ChIP-Seq_K562_Human1.26661413
61TTF2_22483619_ChIP-Seq_HELA_Human1.26184966
62* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25907746
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25884328
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25348800
65KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.24314955
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23726943
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21109101
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20410059
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19791279
70* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18207007
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16297847
72* TFEB_21752829_ChIP-Seq_HELA_Human1.15463183
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15121037
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14438499
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13438966
76NCOR1_26117541_ChIP-Seq_K562_Human1.12362227
77KDM5A_27292631_Chip-Seq_BREAST_Human1.07202965
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.06174612
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05077422
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04835732
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03784518
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03198164
83ELK1_19687146_ChIP-ChIP_HELA_Human1.01427190
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00845240
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98745419
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98314553
87SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96996846
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96001980
89KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93784608
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93160812
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92892878
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92275661
93FOXP1_21924763_ChIP-Seq_HESCs_Human0.91275036
94* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91021029
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90514793
96CIITA_25753668_ChIP-Seq_RAJI_Human0.90457472
97NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90322623
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89531013
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.87718411
100ZNF263_19887448_ChIP-Seq_K562_Human0.87170206
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86245998
102TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.84619736
103MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84041846
104* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83660033
105SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83475485
106SCL_19346495_ChIP-Seq_HPC-7_Human0.82527794
107KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80616874
108TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80113117
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79450216
110MYC_18940864_ChIP-ChIP_HL60_Human0.79328464
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79177906
112IRF1_19129219_ChIP-ChIP_H3396_Human0.77816327
113CTCF_18555785_ChIP-Seq_MESCs_Mouse0.77000752
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76020603
115CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75860000
116YY1_22570637_ChIP-Seq_MALME-3M_Human0.75825960
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75378053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo6.78658281
2MP0004147_increased_porphyrin_level6.37998267
3MP0002139_abnormal_hepatobiliary_system5.65358013
4MP0003806_abnormal_nucleotide_metabolis4.88391415
5MP0005360_urolithiasis4.73934012
6MP0005085_abnormal_gallbladder_physiolo4.41033122
7MP0005365_abnormal_bile_salt4.08351020
8MP0008875_abnormal_xenobiotic_pharmacok3.53703196
9MP0005083_abnormal_biliary_tract3.22711042
10MP0003186_abnormal_redox_activity2.66837563
11MP0006036_abnormal_mitochondrial_physio2.55095433
12MP0009840_abnormal_foam_cell2.50621475
13MP0010329_abnormal_lipoprotein_level2.36313063
14MP0005332_abnormal_amino_acid2.35889824
15MP0008995_early_reproductive_senescence2.10760114
16MP0000372_irregular_coat_pigmentation2.07524902
17MP0001764_abnormal_homeostasis2.05671720
18MP0009697_abnormal_copulation2.04060718
19MP0005636_abnormal_mineral_homeostasis2.02174278
20MP0003693_abnormal_embryo_hatching2.01711337
21MP0003195_calcinosis1.85554307
22MP0001666_abnormal_nutrient_absorption1.77195316
23MP0002132_abnormal_respiratory_system1.75193919
24MP0003011_delayed_dark_adaptation1.73183637
25MP0003111_abnormal_nucleus_morphology1.70818355
26MP0000609_abnormal_liver_physiology1.64331471
27MP0005319_abnormal_enzyme/_coenzyme1.63486236
28MP0003252_abnormal_bile_duct1.63484972
29MP0004957_abnormal_blastocyst_morpholog1.57567467
30MP0010094_abnormal_chromosome_stability1.46533418
31MP0004019_abnormal_vitamin_homeostasis1.43931988
32MP0005584_abnormal_enzyme/coenzyme_acti1.40795976
33MP0002118_abnormal_lipid_homeostasis1.39654569
34MP0003191_abnormal_cellular_cholesterol1.37954549
35MP0000350_abnormal_cell_proliferation1.37648873
36MP0009643_abnormal_urine_homeostasis1.33680016
37MP0003077_abnormal_cell_cycle1.32150824
38MP0006035_abnormal_mitochondrial_morpho1.30704723
39MP0003718_maternal_effect1.30504719
40MP0001697_abnormal_embryo_size1.19760606
41MP0008057_abnormal_DNA_replication1.19106898
42MP0008872_abnormal_physiological_respon1.18972234
43MP0005266_abnormal_metabolism1.15712343
44MP0009333_abnormal_splenocyte_physiolog1.12720946
45MP0002095_abnormal_skin_pigmentation1.12389917
46MP0008058_abnormal_DNA_repair1.12200876
47MP0002837_dystrophic_cardiac_calcinosis1.09514300
48MP0004145_abnormal_muscle_electrophysio1.07735689
49MP0005058_abnormal_lysosome_morphology1.06566150
50MP0001529_abnormal_vocalization1.06064370
51MP0005376_homeostasis/metabolism_phenot1.05996833
52MP0000598_abnormal_liver_morphology1.05321258
53MP0009278_abnormal_bone_marrow1.04622088
54MP0000749_muscle_degeneration1.03746594
55MP0004808_abnormal_hematopoietic_stem1.03585124
56MP0002138_abnormal_hepatobiliary_system1.02033663
57MP0000343_altered_response_to0.98161510
58MP0000678_abnormal_parathyroid_gland0.97677600
59MP0010307_abnormal_tumor_latency0.97491415
60MP0004043_abnormal_pH_regulation0.95821738
61MP0005380_embryogenesis_phenotype0.95366756
62MP0001672_abnormal_embryogenesis/_devel0.95366756
63MP0001727_abnormal_embryo_implantation0.94083599
64MP0005408_hypopigmentation0.92195600
65MP0002877_abnormal_melanocyte_morpholog0.91440579
66MP0003984_embryonic_growth_retardation0.86149338
67MP0001853_heart_inflammation0.85868445
68MP0008260_abnormal_autophagy0.85661616
69MP0001545_abnormal_hematopoietic_system0.82961314
70MP0005397_hematopoietic_system_phenotyp0.82961314
71MP0003868_abnormal_feces_composition0.82940679
72MP0005451_abnormal_body_composition0.81140434
73MP0002088_abnormal_embryonic_growth/wei0.80754724
74MP0005410_abnormal_fertilization0.80266041
75MP0001929_abnormal_gametogenesis0.78860171
76MP0000015_abnormal_ear_pigmentation0.77416427
77MP0002722_abnormal_immune_system0.77226891
78MP0009765_abnormal_xenobiotic_induced0.77018909
79MP0008932_abnormal_embryonic_tissue0.75893406
80MP0009764_decreased_sensitivity_to0.75620625
81MP0001756_abnormal_urination0.75255029
82MP0005075_abnormal_melanosome_morpholog0.75124431
83MP0005171_absent_coat_pigmentation0.74050344
84MP0009379_abnormal_foot_pigmentation0.72451369
85MP0008775_abnormal_heart_ventricle0.71292385
86MP0009763_increased_sensitivity_to0.70944676
87MP0005670_abnormal_white_adipose0.70286109
88MP0001881_abnormal_mammary_gland0.70178520
89MP0004215_abnormal_myocardial_fiber0.69296331
90MP0009642_abnormal_blood_homeostasis0.68883917
91MP0002210_abnormal_sex_determination0.68072476
92MP0005647_abnormal_sex_gland0.67522721
93MP0005384_cellular_phenotype0.66840171
94MP0002398_abnormal_bone_marrow0.66588149
95MP0005220_abnormal_exocrine_pancreas0.65541871
96MP0008469_abnormal_protein_level0.65474815
97MP0002429_abnormal_blood_cell0.62007523
98MP0002086_abnormal_extraembryonic_tissu0.61330280
99MP0001661_extended_life_span0.60871516
100MP0002938_white_spotting0.60582620
101MP0003786_premature_aging0.59408010
102MP0001145_abnormal_male_reproductive0.58527786
103MP0002396_abnormal_hematopoietic_system0.57625958
104MP0002078_abnormal_glucose_homeostasis0.57103386
105MP0000358_abnormal_cell_content/0.56871523
106MP0000653_abnormal_sex_gland0.56602316
107MP0002085_abnormal_embryonic_tissue0.56569056
108MP0005395_other_phenotype0.56472350
109MP0008007_abnormal_cellular_replicative0.56258801
110MP0003646_muscle_fatigue0.55692535
111MP0010030_abnormal_orbit_morphology0.55180140
112MP0000490_abnormal_crypts_of0.55101455
113MP0002822_catalepsy0.54723234
114MP0005330_cardiomyopathy0.52316785
115MP0000747_muscle_weakness0.52308270
116MP0002269_muscular_atrophy0.49603825
117MP0003950_abnormal_plasma_membrane0.49432131
118MP0005535_abnormal_body_temperature0.49218528
119MP0002970_abnormal_white_adipose0.49215518
120MP0000703_abnormal_thymus_morphology0.49073965
121MP0000313_abnormal_cell_death0.48201011
122MP0005334_abnormal_fat_pad0.47945506
123MP0005165_increased_susceptibility_to0.47566153
124MP0006292_abnormal_olfactory_placode0.47089442
125MP0005464_abnormal_platelet_physiology0.46982876
126MP0008873_increased_physiological_sensi0.46922853
127MP0008789_abnormal_olfactory_epithelium0.45294492
128MP0001542_abnormal_bone_strength0.44710867
129MP0003123_paternal_imprinting0.44251837
130MP0001730_embryonic_growth_arrest0.43704325
131MP0006054_spinal_hemorrhage0.43227160
132MP0000689_abnormal_spleen_morphology0.42707116
133MP0002332_abnormal_exercise_endurance0.42472580
134MP0005501_abnormal_skin_physiology0.41052012
135MP0009672_abnormal_birth_weight0.39414081
136* MP0002080_prenatal_lethality0.38180619
137MP0002019_abnormal_tumor_incidence0.38075111
138MP0001905_abnormal_dopamine_level0.37718044
139MP0002971_abnormal_brown_adipose0.37545768
140MP0002136_abnormal_kidney_physiology0.37109099
141MP0009931_abnormal_skin_appearance0.36504045

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)9.02873960
2Poikilocytosis (HP:0004447)6.19980791
3Hypochromic microcytic anemia (HP:0004840)4.88070450
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.72072455
5Acanthocytosis (HP:0001927)4.69243358
6Hyperbilirubinemia (HP:0002904)4.56281868
7Cholelithiasis (HP:0001081)4.41958287
8Reticulocytosis (HP:0001923)4.32756494
9Abnormal gallbladder morphology (HP:0012437)4.12712329
10Abnormal hemoglobin (HP:0011902)3.94309435
11Intrahepatic cholestasis (HP:0001406)3.78194134
12Hypobetalipoproteinemia (HP:0003563)3.74706074
13Hepatic necrosis (HP:0002605)3.71903330
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.62927947
15Prolonged partial thromboplastin time (HP:0003645)3.55025988
16Cerebral edema (HP:0002181)3.50884655
17Acute encephalopathy (HP:0006846)3.47697542
18Hepatocellular necrosis (HP:0001404)3.45614532
19Paralysis (HP:0003470)3.43682598
20Acute necrotizing encephalopathy (HP:0006965)3.40727764
21Hyperammonemia (HP:0001987)3.38755215
22Diaphragmatic weakness (HP:0009113)3.38552149
23Abnormal gallbladder physiology (HP:0012438)3.33189490
24Cholecystitis (HP:0001082)3.33189490
25Abnormal number of erythroid precursors (HP:0012131)3.32899744
26Abnormality of fatty-acid metabolism (HP:0004359)3.29477198
27Abnormality of reticulocytes (HP:0004312)3.29031130
28Deep venous thrombosis (HP:0002625)3.27251463
29Abnormal mitochondria in muscle tissue (HP:0008316)3.25856638
30Hyperglycinemia (HP:0002154)3.24472141
31Nausea (HP:0002018)3.22731904
32Mitochondrial inheritance (HP:0001427)3.22153336
33Abnormality of cells of the erythroid lineage (HP:0012130)3.18848515
34Pallor (HP:0000980)3.18000691
35Xanthomatosis (HP:0000991)3.16067740
36Hypoglycemic coma (HP:0001325)3.09542619
37Microvesicular hepatic steatosis (HP:0001414)3.08796665
38Increased CSF lactate (HP:0002490)3.07884957
39Hyperglycinuria (HP:0003108)3.05517683
40Ileus (HP:0002595)3.03891007
41Abnormality of serine family amino acid metabolism (HP:0010894)3.02104545
42Abnormality of glycine metabolism (HP:0010895)3.02104545
43Lethargy (HP:0001254)2.98001410
44Abnormality of the gallbladder (HP:0005264)2.97095102
45Hypertensive crisis (HP:0100735)2.92919576
46Increased serum lactate (HP:0002151)2.87569250
47Type I transferrin isoform profile (HP:0003642)2.87080960
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.85262810
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.85262810
50Ketosis (HP:0001946)2.84057605
51Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.82989541
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.82472885
53Dicarboxylic aciduria (HP:0003215)2.82472885
54Metabolic acidosis (HP:0001942)2.81707269
55Hyperlipoproteinemia (HP:0010980)2.78117756
56Hypolipoproteinemia (HP:0010981)2.76782824
57Abnormality of methionine metabolism (HP:0010901)2.75377968
58Lactic acidosis (HP:0003128)2.73395019
59Lipid accumulation in hepatocytes (HP:0006561)2.70287053
60Abnormality of serum amino acid levels (HP:0003112)2.69204383
61Petechiae (HP:0000967)2.69194055
62Abnormality of pyrimidine metabolism (HP:0004353)2.67601634
63Microcytic anemia (HP:0001935)2.67505209
64Generalized aminoaciduria (HP:0002909)2.67373251
65Increased serum pyruvate (HP:0003542)2.64222280
66Abnormality of glycolysis (HP:0004366)2.64222280
67Truncus arteriosus (HP:0001660)2.63837437
68Abnormality of aspartate family amino acid metabolism (HP:0010899)2.63478442
69Abnormality of sulfur amino acid metabolism (HP:0004339)2.61853906
70Aplastic anemia (HP:0001915)2.60796603
71Progressive macrocephaly (HP:0004481)2.59325109
72Vomiting (HP:0002013)2.57779947
73Respiratory difficulties (HP:0002880)2.56633992
74Reticulocytopenia (HP:0001896)2.54697279
75Exertional dyspnea (HP:0002875)2.53997943
76Increased muscle lipid content (HP:0009058)2.50711917
773-Methylglutaconic aciduria (HP:0003535)2.50299961
78Brushfield spots (HP:0001088)2.50288175
79Hyperthyroidism (HP:0000836)2.49348240
80Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.45823589
81Birth length less than 3rd percentile (HP:0003561)2.45005723
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42565004
83Abnormal protein N-linked glycosylation (HP:0012347)2.42565004
84Abnormal protein glycosylation (HP:0012346)2.42565004
85Abnormal glycosylation (HP:0012345)2.42565004
86Increased serum ferritin (HP:0003281)2.41620326
87Aplasia/Hypoplasia of the sacrum (HP:0008517)2.38459033
88Cerebral hypomyelination (HP:0006808)2.38284036
89Hypochromic anemia (HP:0001931)2.35339123
90Ragged-red muscle fibers (HP:0003200)2.34998297
91Emotional lability (HP:0000712)2.33588417
92Increased intramyocellular lipid droplets (HP:0012240)2.33357809
93Macrocytic anemia (HP:0001972)2.32631158
94CNS demyelination (HP:0007305)2.32593237
95Increased hepatocellular lipid droplets (HP:0006565)2.31869327
96Abnormality of iron homeostasis (HP:0011031)2.30780685
97Hypoalphalipoproteinemia (HP:0003233)2.27517072
98Nonimmune hydrops fetalis (HP:0001790)2.26462617
99Pancytopenia (HP:0001876)2.24315835
100Redundant skin (HP:0001582)2.23941531
101Joint hemorrhage (HP:0005261)2.23827111
102Fat malabsorption (HP:0002630)2.23547299
103Short middle phalanx of the 5th finger (HP:0004220)2.22725391
104Abnormality of transition element cation homeostasis (HP:0011030)2.21450115
105Abnormality of the intrinsic pathway (HP:0010989)2.20748775
106Glycosuria (HP:0003076)2.20707697
107Abnormality of urine glucose concentration (HP:0011016)2.20707697
108Osteomalacia (HP:0002749)2.20026859
109Respiratory failure (HP:0002878)2.18863213
110Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15625801
111Polycythemia (HP:0001901)2.14335156
112Renal Fanconi syndrome (HP:0001994)2.14293772
113Rough bone trabeculation (HP:0100670)2.14099003
114Seborrheic dermatitis (HP:0001051)2.12042923
115Abnormality of the common coagulation pathway (HP:0010990)2.11814935
116Abnormality of the anterior horn cell (HP:0006802)2.11709352
117Degeneration of anterior horn cells (HP:0002398)2.11709352
118Delayed CNS myelination (HP:0002188)2.09062680
119Abnormality of nucleobase metabolism (HP:0010932)2.07981477
120Multiple enchondromatosis (HP:0005701)2.07324428
121Ketoacidosis (HP:0001993)2.05758206
122Complement deficiency (HP:0004431)2.05480365
123Opisthotonus (HP:0002179)2.04488063
124Secondary amenorrhea (HP:0000869)2.02875985
125* Cutaneous photosensitivity (HP:0000992)2.01691010
126Reduced antithrombin III activity (HP:0001976)1.99551942
127Rhabdomyolysis (HP:0003201)1.99335850
128Leukodystrophy (HP:0002415)1.98730594
129Hypoparathyroidism (HP:0000829)1.98087431
130Renal cortical cysts (HP:0000803)1.96904076
131Progressive muscle weakness (HP:0003323)1.96520356
132Steatorrhea (HP:0002570)1.94546738
133Exercise intolerance (HP:0003546)1.94071118
134Oral leukoplakia (HP:0002745)1.92134284
135Abnormality of renal resorption (HP:0011038)1.91973899
136Spastic paraparesis (HP:0002313)1.91919481
137Premature ovarian failure (HP:0008209)1.90802813
138Delusions (HP:0000746)1.90016325
139Abnormal platelet function (HP:0011869)1.87294309
140Impaired platelet aggregation (HP:0003540)1.87294309
141Myelodysplasia (HP:0002863)1.84994240
142Hepatosplenomegaly (HP:0001433)1.84972013
143Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79220358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK15.68239356
2VRK25.09382714
3BCKDK4.83084554
4BUB14.49246020
5NME23.80402044
6STK163.34878239
7TLK13.05974910
8WEE12.50310738
9CDC72.35164906
10PDK22.28040302
11SCYL22.27755131
12NUAK12.27410519
13VRK12.04133843
14SRPK12.00579613
15NEK11.97741039
16BRSK11.83175358
17DYRK31.72061453
18PBK1.60808087
19BRSK21.55240814
20PINK11.54401174
21ZAK1.54125681
22CLK11.52120390
23SMG11.50194780
24MST41.46240191
25AURKA1.40637263
26MAP3K111.37541324
27STK41.34958328
28KDR1.33439073
29MAPK111.32435123
30PIM21.31893752
31TAOK21.31242848
32TSSK61.29725992
33FLT31.28766470
34NME11.26858846
35TAF11.25384305
36CCNB11.18713234
37PLK41.18631117
38PLK11.17169101
39BRAF1.12481969
40AURKB1.12433527
41RAF11.12144260
42TTK1.11016736
43CDK81.09861020
44ABL21.08843044
45EIF2AK31.08523480
46PIM10.98846339
47ILK0.98619553
48NEK20.97385872
49GRK60.91888277
50MAPKAPK30.90364791
51MAP3K80.88847173
52RPS6KB20.82481268
53CDK190.80262465
54RPS6KA50.78752663
55MAP2K30.77268340
56CDK70.76821656
57TESK20.76660732
58ACVR1B0.76493645
59SIK10.76371253
60CSNK1G30.70732911
61CSNK2A10.67893314
62TESK10.65956355
63PAK10.65853768
64MAPKAPK50.65480404
65BMX0.65248162
66LMTK20.64885181
67MYLK0.64754132
68ATR0.63681280
69CSNK2A20.62728129
70PDK30.62569319
71PDK40.62569319
72CHEK20.61902413
73GRK70.61652533
74LRRK20.61074012
75IRAK30.57763048
76DAPK20.57145464
77PIK3CG0.55043230
78MKNK10.54063235
79CDK40.53684414
80PLK30.52633394
81OBSCN0.51706553
82STK100.51243835
83DAPK10.49553961
84ADRBK20.47260218
85TIE10.46982815
86TAOK30.46612707
87PASK0.46472547
88GRK10.46329676
89RPS6KC10.45684342
90RPS6KL10.45684342
91NEK90.45621641
92MAP2K60.45118985
93ARAF0.44051659
94TEC0.43773256
95DAPK30.43031492
96PAK40.41792325
97RIPK40.41255279
98RPS6KA60.41177536
99MELK0.40596280
100EIF2AK20.39662320
101CSNK1G10.37644769
102CDK20.37349448
103ERN10.37103036
104CSNK1G20.37025733
105CSNK1A1L0.35288937
106ERBB20.34958363
107CDK10.34319735
108PRKAA10.34301951
109AKT30.34274214
110MAPK120.32159676
111MAP3K120.32075430
112MAP3K30.31771919
113CHEK10.31310524
114GRK50.31304281
115DYRK20.30134396
116RPS6KA40.29800975
117INSRR0.29448393
118DYRK1B0.28929956
119JAK20.28127254
120BMPR20.28025074
121PRKACG0.27507932
122LYN0.27376382
123ATM0.27236660
124STK240.27159017
125AKT20.26647423
126CDK11A0.26022971
127ALK0.25379956
128MAPK40.25192799
129PAK20.25128808
130CDK140.24934408
131TRPM70.24541302
132MAP3K50.24347291
133CDK150.23968828
134TBK10.22085519
135CDK180.21753725
136MARK30.20389981

Predicted pathways (KEGG)

RankGene SetZ-score
1* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.36440422
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.65325364
3Vitamin B6 metabolism_Homo sapiens_hsa007502.60824114
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51590490
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.43999632
6Proteasome_Homo sapiens_hsa030502.11422517
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03974296
8DNA replication_Homo sapiens_hsa030302.03518141
9Fatty acid degradation_Homo sapiens_hsa000712.01226219
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.00274919
11Ribosome_Homo sapiens_hsa030101.98661883
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.98519203
13Sulfur relay system_Homo sapiens_hsa041221.98313286
14Propanoate metabolism_Homo sapiens_hsa006401.95084937
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94628134
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93372830
17Folate biosynthesis_Homo sapiens_hsa007901.91056738
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.84851365
19Oxidative phosphorylation_Homo sapiens_hsa001901.77548835
20One carbon pool by folate_Homo sapiens_hsa006701.77219914
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76871886
22Tryptophan metabolism_Homo sapiens_hsa003801.72533457
23Pyruvate metabolism_Homo sapiens_hsa006201.72250991
24Peroxisome_Homo sapiens_hsa041461.71877939
25Parkinsons disease_Homo sapiens_hsa050121.67659091
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.66369752
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.66310466
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.63688247
29Arginine biosynthesis_Homo sapiens_hsa002201.63214412
30Selenocompound metabolism_Homo sapiens_hsa004501.60196766
31Carbon metabolism_Homo sapiens_hsa012001.54149279
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49612130
33Fatty acid elongation_Homo sapiens_hsa000621.48373433
34Biosynthesis of amino acids_Homo sapiens_hsa012301.48246415
35Chemical carcinogenesis_Homo sapiens_hsa052041.44268731
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43826691
37Butanoate metabolism_Homo sapiens_hsa006501.42571143
38beta-Alanine metabolism_Homo sapiens_hsa004101.41042006
39Fatty acid metabolism_Homo sapiens_hsa012121.38741071
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37722454
41Mismatch repair_Homo sapiens_hsa034301.36361125
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36060638
43Complement and coagulation cascades_Homo sapiens_hsa046101.35901840
44Pyrimidine metabolism_Homo sapiens_hsa002401.35502596
45Histidine metabolism_Homo sapiens_hsa003401.35351996
46RNA polymerase_Homo sapiens_hsa030201.33727887
47Tyrosine metabolism_Homo sapiens_hsa003501.29219115
48Phenylalanine metabolism_Homo sapiens_hsa003601.28711970
49Sulfur metabolism_Homo sapiens_hsa009201.28262717
50Glutathione metabolism_Homo sapiens_hsa004801.25466613
51Nitrogen metabolism_Homo sapiens_hsa009101.24198888
52Caffeine metabolism_Homo sapiens_hsa002321.20254091
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18522476
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12736133
55Arginine and proline metabolism_Homo sapiens_hsa003301.11095307
56Retinol metabolism_Homo sapiens_hsa008301.10154433
57Huntingtons disease_Homo sapiens_hsa050161.07805585
58PPAR signaling pathway_Homo sapiens_hsa033201.06256083
59Pentose phosphate pathway_Homo sapiens_hsa000301.05533664
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04429615
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.04136815
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03717174
63Systemic lupus erythematosus_Homo sapiens_hsa053221.00387974
64Nucleotide excision repair_Homo sapiens_hsa034200.99409369
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.96743979
66Base excision repair_Homo sapiens_hsa034100.96125402
67ABC transporters_Homo sapiens_hsa020100.93620270
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93064723
69Alzheimers disease_Homo sapiens_hsa050100.90516479
70* Metabolic pathways_Homo sapiens_hsa011000.89115259
71Homologous recombination_Homo sapiens_hsa034400.88189255
72N-Glycan biosynthesis_Homo sapiens_hsa005100.86822827
73Protein export_Homo sapiens_hsa030600.82979925
74Steroid biosynthesis_Homo sapiens_hsa001000.82890620
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82524770
76Spliceosome_Homo sapiens_hsa030400.80703104
77Cardiac muscle contraction_Homo sapiens_hsa042600.78244081
78Starch and sucrose metabolism_Homo sapiens_hsa005000.71699513
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70396261
80Fat digestion and absorption_Homo sapiens_hsa049750.68349576
81Vitamin digestion and absorption_Homo sapiens_hsa049770.67036889
82Purine metabolism_Homo sapiens_hsa002300.64598051
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63278879
84RNA transport_Homo sapiens_hsa030130.63133811
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.61266640
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60160663
87Cell cycle_Homo sapiens_hsa041100.59348391
88Bile secretion_Homo sapiens_hsa049760.57252708
89Fructose and mannose metabolism_Homo sapiens_hsa000510.55497897
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53440207
91p53 signaling pathway_Homo sapiens_hsa041150.52297034
92Collecting duct acid secretion_Homo sapiens_hsa049660.47386428
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47154816
94Non-homologous end-joining_Homo sapiens_hsa034500.46810653
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45136006
96mRNA surveillance pathway_Homo sapiens_hsa030150.42956486
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42726995
98Oocyte meiosis_Homo sapiens_hsa041140.41897416
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41244274
100Epstein-Barr virus infection_Homo sapiens_hsa051690.40015224
101Galactose metabolism_Homo sapiens_hsa000520.39103984
102Other glycan degradation_Homo sapiens_hsa005110.37930911
103Staphylococcus aureus infection_Homo sapiens_hsa051500.37413899
104Glycerolipid metabolism_Homo sapiens_hsa005610.35815178
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34073087
106RNA degradation_Homo sapiens_hsa030180.33880559
107Regulation of autophagy_Homo sapiens_hsa041400.32764677
108Basal transcription factors_Homo sapiens_hsa030220.31733008
109Fanconi anemia pathway_Homo sapiens_hsa034600.30131084
110Linoleic acid metabolism_Homo sapiens_hsa005910.25797722
111Arachidonic acid metabolism_Homo sapiens_hsa005900.25664866
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.25409195
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24709523
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20716950
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.20536575
116Viral carcinogenesis_Homo sapiens_hsa052030.11509738
117Bladder cancer_Homo sapiens_hsa052190.10584812
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.06505719
119Herpes simplex infection_Homo sapiens_hsa051680.04638264
120Malaria_Homo sapiens_hsa051440.04375361
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.03420202
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.02122313

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