UROS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* protoporphyrinogen IX metabolic process (GO:0046501)9.47749312
2* protoporphyrinogen IX biosynthetic process (GO:0006782)9.33897492
3* heme biosynthetic process (GO:0006783)7.02991768
4* porphyrin-containing compound biosynthetic process (GO:0006779)6.63241577
5* tetrapyrrole biosynthetic process (GO:0033014)6.26647043
6* heme metabolic process (GO:0042168)5.85292065
7* porphyrin-containing compound metabolic process (GO:0006778)5.45287736
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.40211716
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.07819365
10ATP synthesis coupled proton transport (GO:0015986)4.97482576
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.97482576
12pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.74352423
13protein-cofactor linkage (GO:0018065)4.61992237
14respiratory electron transport chain (GO:0022904)4.54901278
15electron transport chain (GO:0022900)4.43254723
16protein maturation by protein folding (GO:0022417)4.42998742
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.08024649
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.08024649
19NADH dehydrogenase complex assembly (GO:0010257)4.08024649
20pyrimidine nucleotide catabolic process (GO:0006244)4.05094339
21pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.03256346
22response to insecticide (GO:0017085)4.01732226
23response to methylmercury (GO:0051597)4.01499277
24protein complex biogenesis (GO:0070271)3.93074102
25chaperone-mediated protein transport (GO:0072321)3.85571662
26NADH metabolic process (GO:0006734)3.78456528
27* tetrapyrrole metabolic process (GO:0033013)3.69867220
28L-phenylalanine catabolic process (GO:0006559)3.66634197
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.66634197
30mitochondrial respiratory chain complex assembly (GO:0033108)3.55278915
31fatty acid elongation (GO:0030497)3.54825026
32succinate metabolic process (GO:0006105)3.51219553
33oxidative phosphorylation (GO:0006119)3.43681310
34positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.43032406
35L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.42020314
36cofactor catabolic process (GO:0051187)3.40069927
37response to lead ion (GO:0010288)3.39500926
38* pigment biosynthetic process (GO:0046148)3.36928603
39peptidyl-arginine omega-N-methylation (GO:0035247)3.35987604
40synaptic vesicle maturation (GO:0016188)3.33397232
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.28441594
42L-phenylalanine metabolic process (GO:0006558)3.28441594
43water-soluble vitamin biosynthetic process (GO:0042364)3.27592797
44amino acid salvage (GO:0043102)3.22484564
45L-methionine salvage (GO:0071267)3.22484564
46L-methionine biosynthetic process (GO:0071265)3.22484564
47tricarboxylic acid cycle (GO:0006099)3.21262899
48cullin deneddylation (GO:0010388)3.19277774
49oxygen transport (GO:0015671)3.18538841
50lipopolysaccharide biosynthetic process (GO:0009103)3.17738961
51deoxyribonucleotide biosynthetic process (GO:0009263)3.17381140
52oxaloacetate metabolic process (GO:0006107)3.14155310
53deoxyribonucleotide catabolic process (GO:0009264)3.11797881
54inner mitochondrial membrane organization (GO:0007007)3.10363956
55protein neddylation (GO:0045116)3.08287105
56* pigment metabolic process (GO:0042440)3.06855778
572-deoxyribonucleotide metabolic process (GO:0009394)3.06573775
58base-excision repair, AP site formation (GO:0006285)3.05901708
59protein deneddylation (GO:0000338)3.05204099
60aerobic respiration (GO:0009060)3.04148788
61mitochondrial calcium ion transport (GO:0006851)3.04089872
62negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.03917290
63protein targeting to mitochondrion (GO:0006626)3.03266233
64lysine metabolic process (GO:0006553)3.01937193
65lysine catabolic process (GO:0006554)3.01937193
66nuclear envelope reassembly (GO:0031468)3.00561901
67mitotic nuclear envelope reassembly (GO:0007084)3.00561901
68ATP biosynthetic process (GO:0006754)2.97339837
69heme transport (GO:0015886)2.97035923
70erythrocyte maturation (GO:0043249)2.96813150
71* cofactor biosynthetic process (GO:0051188)2.96178109
72deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.95932816
73hemoglobin metabolic process (GO:0020027)2.95108434
74cellular ketone body metabolic process (GO:0046950)2.94230472
75deoxyribose phosphate catabolic process (GO:0046386)2.93041608
76nucleobase-containing small molecule interconversion (GO:0015949)2.92535988
77coenzyme catabolic process (GO:0009109)2.92450676
78establishment of protein localization to mitochondrion (GO:0072655)2.91141453
79quinone biosynthetic process (GO:1901663)2.90946536
80ubiquinone biosynthetic process (GO:0006744)2.90946536
81respiratory chain complex IV assembly (GO:0008535)2.88083188
82establishment of protein localization to mitochondrial membrane (GO:0090151)2.87719782
83aromatic amino acid family catabolic process (GO:0009074)2.87694500
84deoxyribose phosphate metabolic process (GO:0019692)2.86824218
85peptidyl-arginine methylation (GO:0018216)2.82718529
86peptidyl-arginine N-methylation (GO:0035246)2.82718529
87gas transport (GO:0015669)2.82386461
88peroxisome fission (GO:0016559)2.81993092
89ubiquinone metabolic process (GO:0006743)2.81614920
90purine nucleoside triphosphate biosynthetic process (GO:0009145)2.81208416
91hydrogen ion transmembrane transport (GO:1902600)2.80974174
92negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.77927934
93histone arginine methylation (GO:0034969)2.75476141
94positive regulation of mitochondrial fission (GO:0090141)2.74990301
95protein localization to mitochondrion (GO:0070585)2.74742676
96deoxyribonucleotide metabolic process (GO:0009262)2.74274655
97very-low-density lipoprotein particle assembly (GO:0034379)2.74148161
98establishment of mitochondrion localization (GO:0051654)2.73923208
99regulation of cellular amino acid metabolic process (GO:0006521)2.73694854
100negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.72796606
101purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.72260557
102regulation of oxidative phosphorylation (GO:0002082)2.71974103
103nucleoside diphosphate biosynthetic process (GO:0009133)2.71477514
104regulation of mitochondrial translation (GO:0070129)2.65153208
105ATP hydrolysis coupled proton transport (GO:0015991)2.65032028
106energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.65032028
107mitochondrial transport (GO:0006839)2.64744545
108regulation of penile erection (GO:0060405)2.64604695
109RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.64288723
110tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.64288723
111pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.64259938
1122-deoxyribonucleotide biosynthetic process (GO:0009265)2.63962801
113deoxyribose phosphate biosynthetic process (GO:0046385)2.63962801
114one-carbon compound transport (GO:0019755)2.63316225
115UV protection (GO:0009650)2.62894104
116Arp2/3 complex-mediated actin nucleation (GO:0034314)2.62538542
117deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.62361195
118proton transport (GO:0015992)2.61120691
119negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.60690768
120negative regulation of calcium ion transmembrane transport (GO:1903170)2.60690768
121cellular respiration (GO:0045333)2.58273965
122lipopolysaccharide metabolic process (GO:0008653)2.58021513
123aspartate family amino acid catabolic process (GO:0009068)2.57319307
124hydrogen transport (GO:0006818)2.56720789
125transferrin transport (GO:0033572)2.56584320
126establishment of integrated proviral latency (GO:0075713)2.55192049
127guanosine-containing compound biosynthetic process (GO:1901070)2.52985445
128protein retention in ER lumen (GO:0006621)2.52784701
129tricarboxylic acid metabolic process (GO:0072350)2.52024573
130branched-chain amino acid catabolic process (GO:0009083)2.51632503
131protein insertion into membrane (GO:0051205)2.51174840
132GMP metabolic process (GO:0046037)2.50891126
133mitochondrial fusion (GO:0008053)2.50370062
134trivalent inorganic cation transport (GO:0072512)2.49318762
135ferric iron transport (GO:0015682)2.49318762
136iron-sulfur cluster assembly (GO:0016226)2.48939410
137metallo-sulfur cluster assembly (GO:0031163)2.48939410
138ketone body metabolic process (GO:1902224)2.48580056
139mitochondrial calcium ion homeostasis (GO:0051560)2.48294977
140protein polyglutamylation (GO:0018095)2.48128965
141proteasome assembly (GO:0043248)2.48128262
142positive regulation of TOR signaling (GO:0032008)2.48080310
143dopamine transport (GO:0015872)2.47972112
144cytochrome complex assembly (GO:0017004)2.47365315
145* cofactor metabolic process (GO:0051186)2.47138725
146deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.45783047
147hydrogen peroxide catabolic process (GO:0042744)2.44913202
148cholesterol biosynthetic process (GO:0006695)2.43925119
149thioester biosynthetic process (GO:0035384)2.43684444
150acyl-CoA biosynthetic process (GO:0071616)2.43684444
151ribonucleoside triphosphate biosynthetic process (GO:0009201)2.43224328
152erythrocyte development (GO:0048821)2.42180314
153protein autoprocessing (GO:0016540)2.40907964
154indolalkylamine catabolic process (GO:0046218)2.39606681

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.25289820
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.86938123
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.22730579
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.13235312
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.07092912
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.03776067
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.03107326
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98636519
9PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.96489345
10E2F7_22180533_ChIP-Seq_HELA_Human2.94147321
11GATA1_22025678_ChIP-Seq_K562_Human2.71860458
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71335667
13TAF15_26573619_Chip-Seq_HEK293_Human2.61772334
14* SRF_21415370_ChIP-Seq_HL-1_Mouse2.58306636
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.57417659
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.45264984
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.44410848
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.42776014
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40080567
20CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.34418214
21GBX2_23144817_ChIP-Seq_PC3_Human2.33131485
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.31355954
23EGR1_23403033_ChIP-Seq_LIVER_Mouse2.22361213
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15248180
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.12939005
26XRN2_22483619_ChIP-Seq_HELA_Human2.11091012
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11034241
28KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.07755445
29ZNF263_19887448_ChIP-Seq_K562_Human1.94578949
30* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94251964
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87052492
32ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.86230028
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82485820
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78927260
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.76791644
36* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.76668272
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76289277
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73916851
39SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.72614075
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.66688125
41VDR_22108803_ChIP-Seq_LS180_Human1.66299831
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65784499
43VDR_23849224_ChIP-Seq_CD4+_Human1.65671856
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61823292
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59467868
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58961627
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58848796
48DCP1A_22483619_ChIP-Seq_HELA_Human1.58741081
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56181048
50RXR_22158963_ChIP-Seq_LIVER_Mouse1.55176408
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.54831684
52HTT_18923047_ChIP-ChIP_STHdh_Human1.50782685
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50052498
54* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48842235
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.48266097
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.47338696
57CIITA_25753668_ChIP-Seq_RAJI_Human1.46780832
58FUS_26573619_Chip-Seq_HEK293_Human1.46074929
59* FOXP3_21729870_ChIP-Seq_TREG_Human1.45117757
60CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.43811918
61TBX5_21415370_ChIP-Seq_HL-1_Mouse1.42526071
62TTF2_22483619_ChIP-Seq_HELA_Human1.41024188
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.38618037
64* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38469750
65CTCF_18555785_ChIP-Seq_MESCs_Mouse1.38377530
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37764374
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37594780
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37113715
69FOXP1_21924763_ChIP-Seq_HESCs_Human1.33582185
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.32461380
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30807111
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30747193
73* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30330224
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28015690
75IRF1_19129219_ChIP-ChIP_H3396_Human1.27591297
76TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.23802617
77ELK1_19687146_ChIP-ChIP_HELA_Human1.22944261
78PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22854832
79* P68_20966046_ChIP-Seq_HELA_Human1.22227133
80* GATA1_19941827_ChIP-Seq_MEL_Mouse1.21800805
81* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20954965
82* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20613227
83KDM5A_27292631_Chip-Seq_BREAST_Human1.19733763
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.19182281
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18863306
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18407926
87P300_19829295_ChIP-Seq_ESCs_Human1.18079078
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18073599
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17158535
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17034649
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16818414
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.15588067
93* GABP_19822575_ChIP-Seq_HepG2_Human1.15198318
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14391181
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13686242
96REST_21632747_ChIP-Seq_MESCs_Mouse1.12550190
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12176134
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11489477
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09589948
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08190430
101SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07955063
102SALL4_22934838_ChIP-ChIP_CD34+_Human1.07843824
103CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07470697
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06723819
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04453977
106KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04316767
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04196900
108BCL6_27268052_Chip-Seq_Bcells_Human1.03854816
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03214035
110E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02983527
111SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02530380
112GATA1_19941826_ChIP-Seq_K562_Human1.00169119
113* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00061206
114BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98602946
115LXR_22292898_ChIP-Seq_THP-1_Human0.96652771
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96412713
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96410035
118* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96273063
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96197681
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95210144
121IGF1R_20145208_ChIP-Seq_DFB_Human0.94822136
122KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94178815
123CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94167828
124* PHF8_20622854_ChIP-Seq_HELA_Human0.93475675
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92819367
126TFEB_21752829_ChIP-Seq_HELA_Human0.91888634
127MYC_18940864_ChIP-ChIP_HL60_Human0.91543809
128FLI1_27457419_Chip-Seq_LIVER_Mouse0.91459863
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91234757
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91198146
131TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90542713
132YY1_22570637_ChIP-Seq_MALME-3M_Human0.89607628
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89546414
134MYC_18555785_ChIP-Seq_MESCs_Mouse0.88682313
135SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88640676
136ER_23166858_ChIP-Seq_MCF-7_Human0.88133265
137MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87990922
138RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87940093
139CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87500643
140DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87247894
141* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86916793
142CTCF_26484167_Chip-Seq_Bcells_Mouse0.86618722
143TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.86225305
144SOX2_19829295_ChIP-Seq_ESCs_Human0.86194079
145NANOG_19829295_ChIP-Seq_ESCs_Human0.86194079
146EWS_26573619_Chip-Seq_HEK293_Human0.86004586
147CTCF_21964334_Chip-Seq_Bcells_Human0.85952660
148LXR_22158963_ChIP-Seq_LIVER_Mouse0.85761096
149TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85691769
150VDR_21846776_ChIP-Seq_THP-1_Human0.85260689
151JUN_21703547_ChIP-Seq_K562_Human0.85107731
152NCOR_22424771_ChIP-Seq_293T_Human0.84766435
153FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.84615064
154REST_19997604_ChIP-ChIP_NEURONS_Mouse0.84308982
155* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83629886
156MYC_19030024_ChIP-ChIP_MESCs_Mouse0.82458710
157OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82019716
158EZH2_22144423_ChIP-Seq_EOC_Human0.81562358
159ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78205213

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004147_increased_porphyrin_level5.58431327
2* MP0003656_abnormal_erythrocyte_physiolo5.51511830
3MP0002139_abnormal_hepatobiliary_system3.06989532
4MP0003806_abnormal_nucleotide_metabolis3.02373008
5MP0001529_abnormal_vocalization2.91459446
6MP0004145_abnormal_muscle_electrophysio2.85476937
7MP0006036_abnormal_mitochondrial_physio2.69823736
8MP0003880_abnormal_central_pattern2.69420462
9MP0002736_abnormal_nociception_after2.59477164
10MP0002837_dystrophic_cardiac_calcinosis2.53188729
11MP0005085_abnormal_gallbladder_physiolo2.41806513
12MP0002735_abnormal_chemical_nociception2.35762250
13MP0008789_abnormal_olfactory_epithelium2.30824521
14MP0001968_abnormal_touch/_nociception2.28019710
15MP0005360_urolithiasis2.26562298
16MP0002822_catalepsy2.20486008
17MP0008875_abnormal_xenobiotic_pharmacok2.12419386
18MP0001986_abnormal_taste_sensitivity2.10646645
19MP0009046_muscle_twitch2.03225729
20MP0000747_muscle_weakness1.95062327
21MP0005365_abnormal_bile_salt1.94491094
22MP0004130_abnormal_muscle_cell1.94363782
23MP0006035_abnormal_mitochondrial_morpho1.92140780
24MP0002876_abnormal_thyroid_physiology1.89356979
25MP0005499_abnormal_olfactory_system1.86120711
26MP0005394_taste/olfaction_phenotype1.86120711
27MP0005083_abnormal_biliary_tract1.84320666
28MP0006276_abnormal_autonomic_nervous1.83666433
29* MP0005636_abnormal_mineral_homeostasis1.80288189
30MP0001905_abnormal_dopamine_level1.80000150
31MP0009745_abnormal_behavioral_response1.76459860
32MP0005670_abnormal_white_adipose1.75662029
33MP0003195_calcinosis1.73548060
34MP0002064_seizures1.72913076
35MP0004215_abnormal_myocardial_fiber1.66810570
36MP0001764_abnormal_homeostasis1.63587695
37MP0004142_abnormal_muscle_tone1.62518732
38MP0000749_muscle_degeneration1.62504333
39MP0002272_abnormal_nervous_system1.61290805
40MP0004043_abnormal_pH_regulation1.60406830
41MP0000750_abnormal_muscle_regeneration1.57892783
42MP0009697_abnormal_copulation1.56565413
43MP0005171_absent_coat_pigmentation1.56439571
44MP0003635_abnormal_synaptic_transmissio1.56131643
45MP0004859_abnormal_synaptic_plasticity1.55958373
46MP0008058_abnormal_DNA_repair1.54425124
47MP0000358_abnormal_cell_content/1.52846858
48MP0000759_abnormal_skeletal_muscle1.52363262
49MP0002734_abnormal_mechanical_nocicepti1.49613212
50MP0003786_premature_aging1.48778544
51MP0004233_abnormal_muscle_weight1.46568074
52MP0003111_abnormal_nucleus_morphology1.46418698
53MP0008872_abnormal_physiological_respon1.41543195
54MP0005332_abnormal_amino_acid1.40440941
55MP0002877_abnormal_melanocyte_morpholog1.40362560
56MP0003646_muscle_fatigue1.39628103
57MP0002638_abnormal_pupillary_reflex1.39409229
58MP0005646_abnormal_pituitary_gland1.38088555
59MP0002106_abnormal_muscle_physiology1.36158750
60MP0002067_abnormal_sensory_capabilities1.29815774
61MP0008932_abnormal_embryonic_tissue1.27252823
62MP0001984_abnormal_olfaction1.26525929
63MP0002572_abnormal_emotion/affect_behav1.25518117
64MP0003329_amyloid_beta_deposits1.25171805
65MP0005330_cardiomyopathy1.24551690
66MP0004924_abnormal_behavior1.24155424
67MP0005386_behavior/neurological_phenoty1.24155424
68MP0005058_abnormal_lysosome_morphology1.23934950
69MP0001970_abnormal_pain_threshold1.22699487
70MP0002733_abnormal_thermal_nociception1.22690085
71MP0004811_abnormal_neuron_physiology1.22157780
72MP0004270_analgesia1.19403230
73MP0004185_abnormal_adipocyte_glucose1.18523816
74MP0005645_abnormal_hypothalamus_physiol1.18452947
75MP0002063_abnormal_learning/memory/cond1.16613259
76MP0001727_abnormal_embryo_implantation1.14879945
77MP0003186_abnormal_redox_activity1.14861942
78MP0001440_abnormal_grooming_behavior1.14602071
79MP0010094_abnormal_chromosome_stability1.13984321
80MP0010329_abnormal_lipoprotein_level1.08111253
81MP0005551_abnormal_eye_electrophysiolog1.08104826
82MP0003183_abnormal_peptide_metabolism1.06827257
83MP0002653_abnormal_ependyma_morphology1.05186817
84MP0005535_abnormal_body_temperature1.03728373
85* MP0005584_abnormal_enzyme/coenzyme_acti1.02839465
86MP0000372_irregular_coat_pigmentation1.02317855
87MP0002160_abnormal_reproductive_system1.01831352
88MP0004087_abnormal_muscle_fiber0.98651630
89MP0005369_muscle_phenotype0.95825870
90MP0008260_abnormal_autophagy0.93172261
91MP0003693_abnormal_embryo_hatching0.92808279
92MP0005379_endocrine/exocrine_gland_phen0.91759611
93MP0002229_neurodegeneration0.91752824
94MP0000751_myopathy0.91624665
95MP0001501_abnormal_sleep_pattern0.90314209
96MP0002132_abnormal_respiratory_system0.88521585
97MP0002118_abnormal_lipid_homeostasis0.87489542
98MP0005397_hematopoietic_system_phenotyp0.87256851
99MP0001545_abnormal_hematopoietic_system0.87256851
100MP0003137_abnormal_impulse_conducting0.86078086
101MP0003136_yellow_coat_color0.85740673
102MP0010386_abnormal_urinary_bladder0.85668845
103MP0001486_abnormal_startle_reflex0.84328016
104MP0003122_maternal_imprinting0.82516422
105MP0003077_abnormal_cell_cycle0.81703951
106MP0004085_abnormal_heartbeat0.81370048
107MP0003011_delayed_dark_adaptation0.80894908
108MP0005319_abnormal_enzyme/_coenzyme0.80711239
109MP0002332_abnormal_exercise_endurance0.80454421
110MP0000230_abnormal_systemic_arterial0.79717990
111MP0000604_amyloidosis0.79349887
112MP0001661_extended_life_span0.79178559
113MP0008775_abnormal_heart_ventricle0.78736417
114MP0001666_abnormal_nutrient_absorption0.78093074
115MP0002882_abnormal_neuron_morphology0.78004294
116MP0000778_abnormal_nervous_system0.77965192
117MP0005376_homeostasis/metabolism_phenot0.77882324
118MP0005620_abnormal_muscle_contractility0.77867047
119MP0005266_abnormal_metabolism0.77387067
120MP0002972_abnormal_cardiac_muscle0.76907855
121MP0005623_abnormal_meninges_morphology0.76653546
122MP0001299_abnormal_eye_distance/0.75535036
123MP0003718_maternal_effect0.74844563
124MP0005452_abnormal_adipose_tissue0.74644377
125MP0005408_hypopigmentation0.74402706
126MP0008438_abnormal_cutaneous_collagen0.73225240
127MP0004036_abnormal_muscle_relaxation0.72687397
128MP0000013_abnormal_adipose_tissue0.72484822
129MP0005666_abnormal_adipose_tissue0.71943083
130MP0002066_abnormal_motor_capabilities/c0.71242336
131MP0002078_abnormal_glucose_homeostasis0.71056786
132MP0003879_abnormal_hair_cell0.70670485
133MP0002177_abnormal_outer_ear0.70293352
134MP0010030_abnormal_orbit_morphology0.69228117
135MP0003631_nervous_system_phenotype0.68476057
136MP0000955_abnormal_spinal_cord0.67769976
137* MP0001542_abnormal_bone_strength0.67730196
138MP0000003_abnormal_adipose_tissue0.67390010
139MP0002557_abnormal_social/conspecific_i0.67360808
140MP0002095_abnormal_skin_pigmentation0.66680576
141MP0000313_abnormal_cell_death0.66481723
142MP0001188_hyperpigmentation0.65430913
143MP0002909_abnormal_adrenal_gland0.63305256
144MP0003868_abnormal_feces_composition0.62035610
145MP0005448_abnormal_energy_balance0.61481429
146MP0002163_abnormal_gland_morphology0.59836919
147MP0009379_abnormal_foot_pigmentation0.59682010
148MP0002269_muscular_atrophy0.59594834
149MP0005084_abnormal_gallbladder_morpholo0.59535956
150MP0005423_abnormal_somatic_nervous0.57910168
151MP0005253_abnormal_eye_physiology0.57896711

Predicted human phenotypes

RankGene SetZ-score
1* Abnormality of the heme biosynthetic pathway (HP:0010472)7.80140567
2Acute necrotizing encephalopathy (HP:0006965)5.23671784
3Abnormal mitochondria in muscle tissue (HP:0008316)5.00377993
4Poikilocytosis (HP:0004447)4.78878536
5Hepatocellular necrosis (HP:0001404)4.71335631
6Mitochondrial inheritance (HP:0001427)4.64236084
7Acute encephalopathy (HP:0006846)4.64027175
8Progressive macrocephaly (HP:0004481)4.35773420
9Hepatic necrosis (HP:0002605)4.35698437
10Increased CSF lactate (HP:0002490)4.24817446
11Hypochromic microcytic anemia (HP:0004840)3.97039712
12Acanthocytosis (HP:0001927)3.76778786
13Cerebral edema (HP:0002181)3.71073367
14Hyperbilirubinemia (HP:0002904)3.64619360
15* Cholelithiasis (HP:0001081)3.56479391
16* Abnormal gallbladder morphology (HP:0012437)3.52521108
17Increased serum pyruvate (HP:0003542)3.44951701
18Abnormality of glycolysis (HP:0004366)3.44951701
19Lactic acidosis (HP:0003128)3.36697001
20Myoglobinuria (HP:0002913)3.32111054
21Increased serum lactate (HP:0002151)3.30379382
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.29577872
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.29577872
24Rhabdomyolysis (HP:0003201)3.24739410
25Reticulocytosis (HP:0001923)3.24502330
263-Methylglutaconic aciduria (HP:0003535)3.17371427
27Diaphragmatic weakness (HP:0009113)3.16694539
28Lipid accumulation in hepatocytes (HP:0006561)3.14478591
29Increased hepatocellular lipid droplets (HP:0006565)3.13323065
30Cholecystitis (HP:0001082)3.10706573
31Abnormal gallbladder physiology (HP:0012438)3.10706573
32Leukodystrophy (HP:0002415)2.94177025
33Neuroendocrine neoplasm (HP:0100634)2.92108765
34Increased intramyocellular lipid droplets (HP:0012240)2.90450517
35Paralysis (HP:0003470)2.90366358
36Respiratory failure (HP:0002878)2.88421675
37Myokymia (HP:0002411)2.87046083
38Hypothermia (HP:0002045)2.86936712
39Insomnia (HP:0100785)2.86816378
40Renal Fanconi syndrome (HP:0001994)2.85814535
41Nemaline bodies (HP:0003798)2.83772846
42Pheochromocytoma (HP:0002666)2.83196172
43Abnormality of aromatic amino acid family metabolism (HP:0004338)2.83109823
44Ileus (HP:0002595)2.81752797
45Focal motor seizures (HP:0011153)2.80043035
46Myopathic facies (HP:0002058)2.75752930
47Muscle fiber inclusion bodies (HP:0100299)2.73927860
48Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.70794304
49Increased muscle lipid content (HP:0009058)2.67471383
50Visual hallucinations (HP:0002367)2.63439944
51Optic disc pallor (HP:0000543)2.62846411
52CNS demyelination (HP:0007305)2.58983152
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.58975226
54Exercise intolerance (HP:0003546)2.58883781
55Lethargy (HP:0001254)2.52842944
56* Abnormality of the gallbladder (HP:0005264)2.47912528
57Epileptic encephalopathy (HP:0200134)2.47167002
58Atonic seizures (HP:0010819)2.46584935
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.45652578
60Emotional lability (HP:0000712)2.39216557
61Vomiting (HP:0002013)2.35501774
62Rimmed vacuoles (HP:0003805)2.34977500
63Delusions (HP:0000746)2.33873149
64Metabolic acidosis (HP:0001942)2.30840409
65Prolonged partial thromboplastin time (HP:0003645)2.30435301
66Progressive muscle weakness (HP:0003323)2.24376968
67Opisthotonus (HP:0002179)2.22458533
68Hyperventilation (HP:0002883)2.21904089
69Ragged-red muscle fibers (HP:0003200)2.20662295
70Abnormal hemoglobin (HP:0011902)2.16984424
71Methylmalonic acidemia (HP:0002912)2.16572292
72Abnormal hair whorl (HP:0010721)2.15481131
73Exercise-induced muscle cramps (HP:0003710)2.12871935
74Cerebral palsy (HP:0100021)2.11981498
75Brushfield spots (HP:0001088)2.11411943
76X-linked dominant inheritance (HP:0001423)2.11354001
77Hypobetalipoproteinemia (HP:0003563)2.10826109
78Hyperthyroidism (HP:0000836)2.09340845
79Ketosis (HP:0001946)2.08934127
80Exercise-induced myalgia (HP:0003738)2.08079283
81Abnormality of reticulocytes (HP:0004312)2.07102561
82Calcaneovalgus deformity (HP:0001848)2.05966837
83Methylmalonic aciduria (HP:0012120)2.05125673
84Type 1 muscle fiber predominance (HP:0003803)2.05025449
85Muscle fiber atrophy (HP:0100295)2.04749275
86Abnormality of urine glucose concentration (HP:0011016)2.03969092
87Glycosuria (HP:0003076)2.03969092
88Respiratory difficulties (HP:0002880)2.03699695
89Polyphagia (HP:0002591)2.02977826
90Abnormal protein glycosylation (HP:0012346)2.02017953
91Abnormal glycosylation (HP:0012345)2.02017953
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02017953
93Abnormal protein N-linked glycosylation (HP:0012347)2.02017953
94Deformed tarsal bones (HP:0008119)2.01537290
95Hand muscle atrophy (HP:0009130)2.00034982
96Limb-girdle muscle atrophy (HP:0003797)1.99768038
97Dicarboxylic aciduria (HP:0003215)1.99630774
98Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99630774
99Abnormality of fatty-acid metabolism (HP:0004359)1.98552193
100Abnormal number of erythroid precursors (HP:0012131)1.97426039
101Upper limb muscle weakness (HP:0003484)1.96659385
102Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95800993
103Gliosis (HP:0002171)1.94648751
104Spastic paraparesis (HP:0002313)1.93123390
105Abnormality of the motor neurons (HP:0002450)1.92865709
106Abnormal neuron morphology (HP:0012757)1.92865709
107Abnormality of the lower motor neuron (HP:0002366)1.91625179
108Microvesicular hepatic steatosis (HP:0001414)1.91099687
109Nonimmune hydrops fetalis (HP:0001790)1.91032047
110Ketoacidosis (HP:0001993)1.90355403
111Myotonia (HP:0002486)1.90094812
112Progressive microcephaly (HP:0000253)1.89802907
113Anxiety (HP:0000739)1.88404712
114Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87951080
115Type I transferrin isoform profile (HP:0003642)1.85769050
116Sensorimotor neuropathy (HP:0007141)1.84720025
117Abnormality of renal resorption (HP:0011038)1.84148790
118Poor suck (HP:0002033)1.83952809
119* Cutaneous photosensitivity (HP:0000992)1.83799840
120Hyperglycinemia (HP:0002154)1.83640886
121Intrahepatic cholestasis (HP:0001406)1.83179565
122Neoplasm of head and neck (HP:0012288)1.82296651
123Esophageal neoplasm (HP:0100751)1.82296651
124Osteomalacia (HP:0002749)1.82101502
125Cerebral hypomyelination (HP:0006808)1.81230163
126Failure to thrive in infancy (HP:0001531)1.81143069
127Hyperammonemia (HP:0001987)1.80531384
128Hypoglycemic coma (HP:0001325)1.80130315
129Febrile seizures (HP:0002373)1.78794298
130Shoulder girdle muscle weakness (HP:0003547)1.77297554
131Aplastic anemia (HP:0001915)1.75959992
132Nausea (HP:0002018)1.75696580
133Atrophy/Degeneration involving motor neurons (HP:0007373)1.75249130
134Polycythemia (HP:0001901)1.74291382
135Hyperphosphaturia (HP:0003109)1.73640900
136Abnormal pupillary function (HP:0007686)1.72274172
137Muscle stiffness (HP:0003552)1.71060610
138Abnormality of methionine metabolism (HP:0010901)1.70389263
139Oligomenorrhea (HP:0000876)1.70108147
140Irregular epiphyses (HP:0010582)1.69678027
141Generalized aminoaciduria (HP:0002909)1.68933034
142Renal cortical cysts (HP:0000803)1.68851014
143Abnormality of cells of the erythroid lineage (HP:0012130)1.68546839
144Type 2 muscle fiber atrophy (HP:0003554)1.67625325
145Generalized tonic-clonic seizures (HP:0002069)1.67383340
146Renal tubular dysfunction (HP:0000124)1.65541545
147Distal upper limb amyotrophy (HP:0007149)1.62356057
148Upper limb amyotrophy (HP:0009129)1.62356057

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.07624266
2EIF2AK13.80729643
3TESK23.51947978
4TESK13.49640207
5CASK3.40436581
6LIMK13.38564541
7STK163.11723938
8SCYL22.72556498
9BCKDK2.66537866
10CCNB12.61158887
11MAP2K72.41367669
12NME12.38904466
13VRK22.26996086
14NTRK32.25492093
15AKT32.22423548
16BUB12.20085461
17KDR2.14716098
18MAP4K22.04281272
19MAP2K41.94332464
20TNIK1.92098361
21PAK61.81596446
22BRSK11.67688377
23CSNK1G31.65392411
24BRSK21.60344386
25LMTK21.59651674
26MAPK131.51040225
27GRK71.45760306
28GRK51.43460658
29DAPK11.41762551
30CSNK1G21.41575189
31MAP3K41.41318765
32BRAF1.40635186
33NTRK11.39185563
34MYLK1.38159357
35VRK11.38107925
36TAOK21.37098929
37TSSK61.36495375
38EPHA41.32779085
39CSNK1A1L1.32418018
40TLK11.32179231
41MAP3K61.29904222
42PLK21.26911267
43OXSR11.24555588
44PDK31.22160479
45PDK41.22160479
46CDK81.19592322
47WNK41.19590010
48EIF2AK31.19360130
49RPS6KA41.12074064
50MINK11.11876831
51DAPK21.10103061
52CSNK1G11.10040195
53NME21.09585138
54ARAF1.05269062
55DAPK31.04094977
56STK391.03769204
57PRPF4B1.00839316
58RPS6KA50.99925633
59SGK2230.99483453
60SGK4940.99483453
61MST40.96690366
62PRKD30.96376947
63PINK10.93837457
64SGK20.92766687
65CAMK2B0.92128690
66CDK190.89844677
67OBSCN0.89711448
68PRKCG0.89381547
69MAPKAPK50.87470659
70TXK0.86293398
71PBK0.86071870
72UHMK10.83815830
73ZAK0.82620396
74RAF10.80299503
75INSRR0.79599294
76BCR0.77003366
77NEK10.76052656
78CAMK2A0.75798353
79PLK10.75742599
80ILK0.74324222
81TTN0.72912330
82MOS0.72783854
83SIK30.69135499
84MUSK0.68320854
85WNK30.67121900
86SYK0.65622088
87NEK20.65102538
88MAPK120.62966514
89CAMK2G0.62511509
90ATR0.62395055
91PRKCE0.62005465
92ERBB40.61057464
93ADRBK10.60301701
94PAK10.59381836
95CAMKK10.58689340
96PLK30.58487111
97BMPR20.58335846
98DYRK20.57705400
99PLK40.57612489
100AURKA0.56981025
101DYRK1A0.56839896
102AKT20.56773303
103PIM20.56328167
104CDK50.56093146
105WEE10.55805604
106ACVR1B0.54974965
107MAP3K110.54692527
108SRPK10.53810338
109PDK20.53173196
110PKN10.53063914
111MARK10.52618196
112CDK180.52497816
113PIK3CA0.51689739
114MAP2K20.51591798
115MAPK110.51281627
116ABL20.49825691
117CDK140.49659495
118CAMK2D0.49121997
119PRKACA0.47895129
120AURKB0.47361738
121CDK150.47102712
122MAP2K10.46697678
123BMPR1B0.45344546
124STK240.44943924
125PHKG20.43884471
126PHKG10.43884471
127DYRK1B0.41203829
128PIK3CG0.39851472
129CAMK10.39834906
130CDK11A0.38813354
131TEC0.38739949
132CSNK2A10.37873094
133EPHB20.37246694
134SGK10.37206270
135PRKACG0.36985307
136CDC70.36706962
137DYRK30.36353408
138CHEK20.35855901
139CAMKK20.35683372
140CSNK2A20.34581658
141MAP3K50.33809864
142NUAK10.30026013

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.06727088
2* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.76733180
3Parkinsons disease_Homo sapiens_hsa050123.40397036
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.72502747
5Proteasome_Homo sapiens_hsa030502.56477570
6Base excision repair_Homo sapiens_hsa034102.44758768
7Alzheimers disease_Homo sapiens_hsa050102.41808208
8Vitamin B6 metabolism_Homo sapiens_hsa007502.27243289
9Huntingtons disease_Homo sapiens_hsa050162.24192030
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20886159
11Collecting duct acid secretion_Homo sapiens_hsa049662.15194450
12Fatty acid elongation_Homo sapiens_hsa000622.12492762
13Pyruvate metabolism_Homo sapiens_hsa006202.07148919
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.03348194
15Propanoate metabolism_Homo sapiens_hsa006402.02246381
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93943659
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.84299879
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82255978
19Butanoate metabolism_Homo sapiens_hsa006501.82191917
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80269570
21Protein export_Homo sapiens_hsa030601.78139170
22Sulfur metabolism_Homo sapiens_hsa009201.77522939
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70762755
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.70164746
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67028836
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62910476
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59731808
28Mismatch repair_Homo sapiens_hsa034301.59586240
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58925110
30Peroxisome_Homo sapiens_hsa041461.53363841
31Synaptic vesicle cycle_Homo sapiens_hsa047211.41455782
32Fatty acid degradation_Homo sapiens_hsa000711.36949968
33Cardiac muscle contraction_Homo sapiens_hsa042601.35946450
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.27592572
35RNA polymerase_Homo sapiens_hsa030201.24948790
36Fatty acid metabolism_Homo sapiens_hsa012121.24766323
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.23771755
38Carbon metabolism_Homo sapiens_hsa012001.22012020
39Nicotine addiction_Homo sapiens_hsa050331.20873689
40beta-Alanine metabolism_Homo sapiens_hsa004101.18310848
41Tryptophan metabolism_Homo sapiens_hsa003801.15580059
42Steroid biosynthesis_Homo sapiens_hsa001001.14007008
43Phenylalanine metabolism_Homo sapiens_hsa003601.11922687
44Homologous recombination_Homo sapiens_hsa034401.07064211
45Folate biosynthesis_Homo sapiens_hsa007901.05391430
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03888895
47Histidine metabolism_Homo sapiens_hsa003401.03611713
48Vibrio cholerae infection_Homo sapiens_hsa051101.02664604
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01597489
50Fanconi anemia pathway_Homo sapiens_hsa034600.98914763
51* Metabolic pathways_Homo sapiens_hsa011000.98898149
52Tyrosine metabolism_Homo sapiens_hsa003500.98870064
53Pyrimidine metabolism_Homo sapiens_hsa002400.97591473
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.96448516
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94779018
56ABC transporters_Homo sapiens_hsa020100.93929370
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.91780833
58Ribosome_Homo sapiens_hsa030100.91452560
59Arginine biosynthesis_Homo sapiens_hsa002200.90208192
60Sulfur relay system_Homo sapiens_hsa041220.88751836
61Glutathione metabolism_Homo sapiens_hsa004800.87741080
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84528272
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84359565
64Spliceosome_Homo sapiens_hsa030400.83460062
65Biosynthesis of amino acids_Homo sapiens_hsa012300.81851853
66GABAergic synapse_Homo sapiens_hsa047270.78227797
67Regulation of autophagy_Homo sapiens_hsa041400.77800568
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77436360
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76449306
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75886613
71Galactose metabolism_Homo sapiens_hsa000520.75199986
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.71822401
73Fructose and mannose metabolism_Homo sapiens_hsa000510.71191851
74Selenocompound metabolism_Homo sapiens_hsa004500.70702526
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70537549
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70181928
77Arginine and proline metabolism_Homo sapiens_hsa003300.68886775
78N-Glycan biosynthesis_Homo sapiens_hsa005100.67466175
79RNA transport_Homo sapiens_hsa030130.65398751
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64058411
81Dilated cardiomyopathy_Homo sapiens_hsa054140.63162965
82Phototransduction_Homo sapiens_hsa047440.62522846
83Chemical carcinogenesis_Homo sapiens_hsa052040.62228086
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60557700
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60553315
86Purine metabolism_Homo sapiens_hsa002300.60408952
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.60347405
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57859934
89Taste transduction_Homo sapiens_hsa047420.53836214
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53295341
91Oocyte meiosis_Homo sapiens_hsa041140.52569373
92PPAR signaling pathway_Homo sapiens_hsa033200.49879401
93Complement and coagulation cascades_Homo sapiens_hsa046100.49382815
94Pentose phosphate pathway_Homo sapiens_hsa000300.49047432
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.48324195
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48246978
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47691945
98Serotonergic synapse_Homo sapiens_hsa047260.47539639
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47357298
100Vitamin digestion and absorption_Homo sapiens_hsa049770.47203454
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47090531
102One carbon pool by folate_Homo sapiens_hsa006700.46789069
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46197173
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45479668
105Cell cycle_Homo sapiens_hsa041100.45300695
106Morphine addiction_Homo sapiens_hsa050320.44892229
107Systemic lupus erythematosus_Homo sapiens_hsa053220.44585091
108Shigellosis_Homo sapiens_hsa051310.43336761
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42362919
110Non-homologous end-joining_Homo sapiens_hsa034500.41873420
111Nucleotide excision repair_Homo sapiens_hsa034200.39848104
112AMPK signaling pathway_Homo sapiens_hsa041520.38737866
113Dopaminergic synapse_Homo sapiens_hsa047280.37679616
114Retinol metabolism_Homo sapiens_hsa008300.37315948
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36875946
116Alcoholism_Homo sapiens_hsa050340.36722595
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36354159
118Amphetamine addiction_Homo sapiens_hsa050310.36105418
119DNA replication_Homo sapiens_hsa030300.35288848
120Circadian entrainment_Homo sapiens_hsa047130.34608935
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34522775
122Basal transcription factors_Homo sapiens_hsa030220.34130459
123Olfactory transduction_Homo sapiens_hsa047400.33078492
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32834373
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30775923
126Bile secretion_Homo sapiens_hsa049760.30389439
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29780740
128Insulin secretion_Homo sapiens_hsa049110.29683326
129Starch and sucrose metabolism_Homo sapiens_hsa005000.27320875
130Ether lipid metabolism_Homo sapiens_hsa005650.25733691
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25357809
132Lysosome_Homo sapiens_hsa041420.24407021

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