USB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with several conserved domains, however, its exact function is not known. Mutations in this gene are associated with poikiloderma with neutropenia (PN), which shows phenotypic overlap with Rothmund-Thomson syndrome (RTS) caused by mutations in the RECQL4 gene. It is believed that this gene product interacts with RECQL4 protein via SMAD4 proteins, explaining the partial clinical overlap between PN and RTS. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.43778696
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.43778696
3negative regulation of cell killing (GO:0031342)4.26448693
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.26448693
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.04958798
6antigen processing and presentation of endogenous antigen (GO:0019883)3.89708321
7response to host (GO:0075136)3.87073566
8response to host defenses (GO:0052200)3.87073566
9response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.87073566
10immunoglobulin mediated immune response (GO:0016064)3.85637217
11detection of other organism (GO:0098543)3.81929211
12pentose-phosphate shunt (GO:0006098)3.76715595
13NADPH regeneration (GO:0006740)3.73572650
14neutrophil activation (GO:0042119)3.71546646
15detection of bacterium (GO:0016045)3.65709307
16response to interferon-beta (GO:0035456)3.63633229
17detection of molecule of bacterial origin (GO:0032490)3.57510672
18ribosomal small subunit assembly (GO:0000028)3.54957336
19regulation of mast cell degranulation (GO:0043304)3.52443693
20positive regulation of interferon-alpha production (GO:0032727)3.52375728
21response to peptidoglycan (GO:0032494)3.52231100
22cellular response to type I interferon (GO:0071357)3.51958019
23type I interferon signaling pathway (GO:0060337)3.51958019
24response to type I interferon (GO:0034340)3.46861169
25positive regulation by symbiont of host defense response (GO:0052509)3.43232832
26modulation by symbiont of host defense response (GO:0052031)3.43232832
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.43232832
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.43232832
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.43232832
30modulation by symbiont of host immune response (GO:0052553)3.43232832
31neutrophil activation involved in immune response (GO:0002283)3.42173793
32detection of external biotic stimulus (GO:0098581)3.41415710
33positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.41016511
34leukocyte migration involved in inflammatory response (GO:0002523)3.40275629
35cellular response to interferon-beta (GO:0035458)3.38047513
36B cell mediated immunity (GO:0019724)3.37120656
37tachykinin receptor signaling pathway (GO:0007217)3.36099181
38regulation of interferon-alpha production (GO:0032647)3.35561103
39positive regulation of gamma-delta T cell activation (GO:0046645)3.32463251
40regulation of T-helper 2 cell differentiation (GO:0045628)3.23238040
41regulation of myeloid leukocyte mediated immunity (GO:0002886)3.19332263
42regulation of leukocyte degranulation (GO:0043300)3.14707553
43response to interferon-alpha (GO:0035455)3.13365596
44Arp2/3 complex-mediated actin nucleation (GO:0034314)3.13325171
45regulation of superoxide anion generation (GO:0032928)3.13095026
46regulation of mast cell activation involved in immune response (GO:0033006)3.09171861
47leukocyte aggregation (GO:0070486)3.07592763
48detection of biotic stimulus (GO:0009595)3.04758644
49respiratory burst (GO:0045730)2.99804286
50regulation of chemokine biosynthetic process (GO:0045073)2.99454226
51positive regulation of chemokine biosynthetic process (GO:0045080)2.99364419
52negative regulation of viral genome replication (GO:0045071)2.99098025
53DNA deamination (GO:0045006)2.97375239
54positive regulation of cellular amide metabolic process (GO:0034250)2.97331313
55defense response to protozoan (GO:0042832)2.97271819
56cellular extravasation (GO:0045123)2.96125706
57antigen processing and presentation via MHC class Ib (GO:0002475)2.95770800
58pinocytosis (GO:0006907)2.93647752
59myeloid cell activation involved in immune response (GO:0002275)2.92917618
60positive regulation of interferon-beta production (GO:0032728)2.91830347
61positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.91555605
62positive regulation of Cdc42 GTPase activity (GO:0043089)2.91371762
63positive regulation of B cell differentiation (GO:0045579)2.89988019
64regulation of type I interferon-mediated signaling pathway (GO:0060338)2.87342227
65regulation of protein heterodimerization activity (GO:0043497)2.84957511
66formation of translation preinitiation complex (GO:0001731)2.82792797
67NIK/NF-kappaB signaling (GO:0038061)2.81505815
68positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80433937
69response to protozoan (GO:0001562)2.79758461
703-UTR-mediated mRNA stabilization (GO:0070935)2.79155476
71protein maturation by protein folding (GO:0022417)2.77901773
72pyrimidine-containing compound salvage (GO:0008655)2.75913878
73pyrimidine nucleoside salvage (GO:0043097)2.75913878
74viral transcription (GO:0019083)2.75593830
75response to muramyl dipeptide (GO:0032495)2.74991579
76regulation of interleukin-12 biosynthetic process (GO:0045075)2.74815751
77interferon-gamma-mediated signaling pathway (GO:0060333)2.74202165
78cellular response to virus (GO:0098586)2.73524946
79antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.72654812
80positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.72532999
81positive regulation of mast cell activation (GO:0033005)2.69554983
82T cell migration (GO:0072678)2.68015970
83COPI coating of Golgi vesicle (GO:0048205)2.66102412
84Golgi transport vesicle coating (GO:0048200)2.66102412
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.65757616
86regulation of podosome assembly (GO:0071801)2.65144551
87regulation of regulated secretory pathway (GO:1903305)2.64688763
88response to interleukin-15 (GO:0070672)2.64619411
89natural killer cell mediated immunity (GO:0002228)2.64430261
90natural killer cell mediated cytotoxicity (GO:0042267)2.64430261
91translational termination (GO:0006415)2.63765063
92glucose catabolic process (GO:0006007)2.63613690
93regulation of amyloid precursor protein catabolic process (GO:1902991)2.62941301
94positive regulation of leukocyte degranulation (GO:0043302)2.62898186
95lipopolysaccharide-mediated signaling pathway (GO:0031663)2.62464575
96positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.62289887
97regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.61525265
98cellular response to exogenous dsRNA (GO:0071360)2.60952106
99positive regulation of mast cell degranulation (GO:0043306)2.60072940
100positive regulation of mast cell activation involved in immune response (GO:0033008)2.60072940
101negative regulation of myeloid cell apoptotic process (GO:0033033)2.59753324
102maturation of SSU-rRNA (GO:0030490)2.59099359
103cellular response to zinc ion (GO:0071294)2.58670835
104DNA strand elongation involved in DNA replication (GO:0006271)2.58625442
105stress fiber assembly (GO:0043149)2.55744966
106regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.55557253
107negative regulation of erythrocyte differentiation (GO:0045647)2.55417827
108DNA strand elongation (GO:0022616)2.54920031
109regulation of defense response to virus by virus (GO:0050690)2.54854252
110telomere maintenance via semi-conservative replication (GO:0032201)2.54550694
111negative regulation of phagocytosis (GO:0050765)2.53841308
112regulation of mast cell activation (GO:0033003)2.52721372
113glucose 6-phosphate metabolic process (GO:0051156)2.52697286
114myeloid dendritic cell differentiation (GO:0043011)2.52366951
115negative regulation of lymphocyte mediated immunity (GO:0002707)2.51908025
116positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.49545860
117regulation of B cell differentiation (GO:0045577)2.49405593
118regulation of response to interferon-gamma (GO:0060330)2.48494913
119SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.48382499
120translational elongation (GO:0006414)2.48360139
121regulation of B cell receptor signaling pathway (GO:0050855)2.47141150
122T cell apoptotic process (GO:0070231)2.45837369
123protein localization to endosome (GO:0036010)2.45470133
124macrophage activation (GO:0042116)2.44920464
125leukocyte degranulation (GO:0043299)2.43661873
126negative regulation of glycoprotein biosynthetic process (GO:0010561)2.43339848
127positive regulation of regulated secretory pathway (GO:1903307)2.43258912
128phospholipid scrambling (GO:0017121)2.42072097
129negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.41810663
130positive regulation of NF-kappaB import into nucleus (GO:0042346)2.41762323
131regulation of interferon-beta biosynthetic process (GO:0045357)2.41099859
132protein targeting to ER (GO:0045047)2.38624365
133positive regulation of type I interferon production (GO:0032481)2.37969006
134cotranslational protein targeting to membrane (GO:0006613)2.37164774
135regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.36402769
136telomere maintenance via recombination (GO:0000722)2.35681944
137folic acid-containing compound biosynthetic process (GO:0009396)2.33703076
138regulation of vitamin D biosynthetic process (GO:0060556)2.33698723
139endosome to melanosome transport (GO:0035646)2.33434914
140endosome to pigment granule transport (GO:0043485)2.33434914
141response to host immune response (GO:0052572)2.33324288
142response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.33324288
143production of molecular mediator involved in inflammatory response (GO:0002532)2.33176245
144leukocyte mediated cytotoxicity (GO:0001909)2.32413101
145regulation of interferon-beta production (GO:0032648)2.30888734
146negative regulation of interleukin-12 production (GO:0032695)2.30121338
147DNA unwinding involved in DNA replication (GO:0006268)2.29635174
148myeloid dendritic cell activation (GO:0001773)2.29322613
149positive regulation of antigen processing and presentation (GO:0002579)2.28942620
150protein localization to endoplasmic reticulum (GO:0070972)2.27738235
151regulation of gamma-delta T cell activation (GO:0046643)2.27494010
152granulocyte activation (GO:0036230)2.26651372
153positive regulation of natural killer cell differentiation (GO:0032825)2.26636613
154translational initiation (GO:0006413)2.24752367
155regulation of T-helper 1 cell differentiation (GO:0045625)2.23447230
156establishment of protein localization to endoplasmic reticulum (GO:0072599)2.22752449
157cellular response to interferon-gamma (GO:0071346)2.22220882
158ribosomal small subunit biogenesis (GO:0042274)2.22173434
159antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.20728344
160macrophage activation involved in immune response (GO:0002281)2.20714342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.05408922
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.57646947
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.26595568
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.13881769
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.93754106
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.79816616
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.58777659
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.52031741
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41642137
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.34586120
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.29559809
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.21601561
13MYC_22102868_ChIP-Seq_BL_Human2.16527661
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.07051966
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03122852
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.02660302
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99726844
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98306537
19MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92538184
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92507321
21SPI1_23547873_ChIP-Seq_NB4_Human1.91968848
22* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.91645286
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89996418
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87786513
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.86458306
26VDR_21846776_ChIP-Seq_THP-1_Human1.86244235
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85578967
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80282037
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79847491
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77957492
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.77875360
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76547073
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.75950883
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.75949054
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74562142
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74465355
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.73590803
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73360038
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.70855273
40LXR_22292898_ChIP-Seq_THP-1_Human1.69823385
41VDR_23849224_ChIP-Seq_CD4+_Human1.69783669
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69724161
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69371859
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.67390451
45XRN2_22483619_ChIP-Seq_HELA_Human1.62611075
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60863622
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60828815
48SPI1_23127762_ChIP-Seq_K562_Human1.58460314
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52887695
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51502438
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50836974
52SCL_19346495_ChIP-Seq_HPC-7_Human1.50768391
53MAF_26560356_Chip-Seq_TH1_Human1.50569680
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49980743
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48561321
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48302606
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.48165414
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47819345
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46450345
60FOXP3_21729870_ChIP-Seq_TREG_Human1.46167232
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44946604
62MYB_26560356_Chip-Seq_TH2_Human1.42694181
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42666475
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38996820
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38807406
66TFEB_21752829_ChIP-Seq_HELA_Human1.38203857
67DCP1A_22483619_ChIP-Seq_HELA_Human1.37247119
68KDM2B_26808549_Chip-Seq_DND41_Human1.37110567
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36300183
70RACK7_27058665_Chip-Seq_MCF-7_Human1.35302909
71GABP_19822575_ChIP-Seq_HepG2_Human1.32445030
72VDR_24763502_ChIP-Seq_THP-1_Human1.31992898
73* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29955972
74UTX_26944678_Chip-Seq_JUKART_Human1.29544455
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29482266
76CIITA_25753668_ChIP-Seq_RAJI_Human1.28899077
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.28673656
78MYB_26560356_Chip-Seq_TH1_Human1.28398295
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25864122
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25645776
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25459615
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25298225
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25274091
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22773004
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20179359
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.18359464
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16125709
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15601568
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15446116
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15203186
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15147381
92E2F1_21310950_ChIP-Seq_MCF-7_Human1.15083547
93NCOR1_26117541_ChIP-Seq_K562_Human1.14609487
94ELK1_19687146_ChIP-ChIP_HELA_Human1.14511360
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13834726
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.13731124
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13502974
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12757884
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12180068
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11886233
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11595957
102GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11544461
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11271821
104TET1_21451524_ChIP-Seq_MESCs_Mouse1.10841765
105ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10669587
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10191320
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09850411
108MAF_26560356_Chip-Seq_TH2_Human1.09840375
109PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09341375
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08867027
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07951259
112TTF2_22483619_ChIP-Seq_HELA_Human1.07736137
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07524924
114RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07403786
115ATF3_27146783_Chip-Seq_COLON_Human1.07312715
116BCL6_27268052_Chip-Seq_Bcells_Human1.07063380
117MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06908582
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06317913
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05885524
120MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05522776
121MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05039751
122KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04750080
123PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04099295
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04090724
125BCOR_27268052_Chip-Seq_Bcells_Human1.04081223
126ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03704494
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03355113
128E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03310933
129TCF7_22412390_ChIP-Seq_EML_Mouse1.02872203
130CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02795961
131CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02236171
132ELK3_25401928_ChIP-Seq_HUVEC_Human1.02033745
133CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01366405
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00151641
135YY1_21170310_ChIP-Seq_MESCs_Mouse0.98535473
136KDM5A_27292631_Chip-Seq_BREAST_Human0.98098734
137THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97548635
138HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95608452
139KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95567031

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.54447548
2MP0009785_altered_susceptibility_to3.49880786
3MP0008260_abnormal_autophagy3.48729106
4MP0003436_decreased_susceptibility_to3.44764960
5MP0005451_abnormal_body_composition2.78114289
6MP0000685_abnormal_immune_system2.73573469
7MP0005000_abnormal_immune_tolerance2.66446421
8MP0005025_abnormal_response_to2.62463789
9MP0005671_abnormal_response_to2.54622995
10MP0002148_abnormal_hypersensitivity_rea2.52740471
11MP0003693_abnormal_embryo_hatching2.49267440
12MP0002419_abnormal_innate_immunity2.41567581
13MP0001800_abnormal_humoral_immune2.34197118
14MP0002452_abnormal_antigen_presenting2.30934743
15MP0005387_immune_system_phenotype2.30845453
16MP0001790_abnormal_immune_system2.30845453
17MP0009333_abnormal_splenocyte_physiolog2.26034890
18MP0006082_CNS_inflammation2.25439029
19MP0002723_abnormal_immune_serum2.22911789
20MP0001853_heart_inflammation2.18226161
21MP0003724_increased_susceptibility_to2.17653004
22MP0003303_peritoneal_inflammation2.15622738
23MP0001819_abnormal_immune_cell2.12880494
24MP0002420_abnormal_adaptive_immunity2.12212522
25MP0005464_abnormal_platelet_physiology1.95785299
26MP0002398_abnormal_bone_marrow1.95573380
27MP0000858_altered_metastatic_potential1.92991679
28MP0002405_respiratory_system_inflammati1.87149970
29MP0003763_abnormal_thymus_physiology1.85406757
30MP0005058_abnormal_lysosome_morphology1.84620462
31MP0000716_abnormal_immune_system1.78834074
32MP0001545_abnormal_hematopoietic_system1.78745079
33MP0005397_hematopoietic_system_phenotyp1.78745079
34MP0002396_abnormal_hematopoietic_system1.77892762
35MP0003077_abnormal_cell_cycle1.76365249
36MP0004957_abnormal_blastocyst_morpholog1.73581751
37MP0004947_skin_inflammation1.73369067
38MP0001533_abnormal_skeleton_physiology1.70623642
39MP0000689_abnormal_spleen_morphology1.69519585
40MP0009278_abnormal_bone_marrow1.68926258
41MP0008007_abnormal_cellular_replicative1.68833787
42MP0000490_abnormal_crypts_of1.68658992
43MP0010352_gastrointestinal_tract_polyps1.67729209
44MP0010155_abnormal_intestine_physiology1.67139719
45MP0001845_abnormal_inflammatory_respons1.66327904
46MP0004808_abnormal_hematopoietic_stem1.65093148
47MP0002722_abnormal_immune_system1.64116078
48MP0002429_abnormal_blood_cell1.62547360
49MP0002006_tumorigenesis1.62274152
50MP0010094_abnormal_chromosome_stability1.60771676
51MP0009840_abnormal_foam_cell1.59907427
52MP0010307_abnormal_tumor_latency1.58780106
53MP0003111_abnormal_nucleus_morphology1.54317530
54MP0008057_abnormal_DNA_replication1.47754405
55MP0008469_abnormal_protein_level1.46088052
56MP0002166_altered_tumor_susceptibility1.45832733
57MP0003448_altered_tumor_morphology1.44255084
58MP0003300_gastrointestinal_ulcer1.43656641
59MP0003705_abnormal_hypodermis_morpholog1.37728945
60MP0000343_altered_response_to1.34476099
61MP0004510_myositis1.32738668
62MP0003186_abnormal_redox_activity1.32469390
63MP0008058_abnormal_DNA_repair1.30663700
64MP0003172_abnormal_lysosome_physiology1.28048726
65MP0000703_abnormal_thymus_morphology1.25584229
66MP0002019_abnormal_tumor_incidence1.21912491
67MP0004233_abnormal_muscle_weight1.18791361
68MP0002138_abnormal_hepatobiliary_system1.18537204
69MP0009764_decreased_sensitivity_to1.16631969
70MP0003191_abnormal_cellular_cholesterol1.16113359
71MP0002933_joint_inflammation1.12781586
72MP0003656_abnormal_erythrocyte_physiolo1.12305089
73MP0003866_abnormal_defecation1.06609125
74MP0005174_abnormal_tail_pigmentation1.05581746
75MP0000465_gastrointestinal_hemorrhage1.05544543
76MP0001873_stomach_inflammation1.04802935
77MP0005023_abnormal_wound_healing1.04182709
78MP0000313_abnormal_cell_death1.03620167
79MP0000678_abnormal_parathyroid_gland0.99831898
80MP0004858_abnormal_nervous_system0.93411172
81MP0002877_abnormal_melanocyte_morpholog0.92474462
82MP0009763_increased_sensitivity_to0.90318213
83MP0003453_abnormal_keratinocyte_physiol0.90014943
84MP0003566_abnormal_cell_adhesion0.88944802
85MP0001851_eye_inflammation0.88456918
86MP0000350_abnormal_cell_proliferation0.88004104
87MP0003091_abnormal_cell_migration0.87290857
88MP0005075_abnormal_melanosome_morpholog0.84752386
89MP0003806_abnormal_nucleotide_metabolis0.84724987
90MP0001915_intracranial_hemorrhage0.84680607
91MP0005390_skeleton_phenotype0.84430752
92MP0001849_ear_inflammation0.83946965
93MP0002089_abnormal_postnatal_growth/wei0.81712879
94MP0006054_spinal_hemorrhage0.81295003
95MP0005310_abnormal_salivary_gland0.80410743
96MP0004381_abnormal_hair_follicle0.78875523
97MP0005384_cellular_phenotype0.78856956
98MP0005164_abnormal_response_to0.76857665
99MP0005076_abnormal_cell_differentiation0.76436847
100MP0000371_diluted_coat_color0.74871318
101MP0001730_embryonic_growth_arrest0.73761732
102MP0002796_impaired_skin_barrier0.73050743
103MP0002998_abnormal_bone_remodeling0.72553041
104MP0006035_abnormal_mitochondrial_morpho0.71524976
105MP0005083_abnormal_biliary_tract0.71497876
106MP0000015_abnormal_ear_pigmentation0.71395588
107MP0002277_abnormal_respiratory_mucosa0.70041612
108MP0000598_abnormal_liver_morphology0.68932077
109MP0005257_abnormal_intraocular_pressure0.68923320
110MP0008004_abnormal_stomach_pH0.68345792
111MP0003075_altered_response_to0.67687001
112MP0005166_decreased_susceptibility_to0.67523612
113MP0008932_abnormal_embryonic_tissue0.67393519
114MP0002132_abnormal_respiratory_system0.65541617
115MP0000358_abnormal_cell_content/0.65392866
116MP0005621_abnormal_cell_physiology0.62807975
117MP0005319_abnormal_enzyme/_coenzyme0.62226221
118MP0003221_abnormal_cardiomyocyte_apopto0.62164634
119MP0008873_increased_physiological_sensi0.59809425
120MP0004782_abnormal_surfactant_physiolog0.59743555
121MP0003828_pulmonary_edema0.59654532
122MP0000604_amyloidosis0.58472779
123MP0002080_prenatal_lethality0.58414028
124MP0000477_abnormal_intestine_morphology0.57820275

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.21056285
2Recurrent abscess formation (HP:0002722)5.08861973
3Eczematoid dermatitis (HP:0000976)4.76075567
4Recurrent bacterial skin infections (HP:0005406)4.44093113
5Myositis (HP:0100614)4.24642549
6Abnormality of macrophages (HP:0004311)3.95962351
7Vacuolated lymphocytes (HP:0001922)3.81888024
8Episodic fever (HP:0001954)3.72804790
9Thrombocytosis (HP:0001894)3.71810606
10Mediastinal lymphadenopathy (HP:0100721)3.69056137
11Recurrent gram-negative bacterial infections (HP:0005420)3.49463478
12Orchitis (HP:0100796)3.43331822
13Petechiae (HP:0000967)3.34663795
14Cholecystitis (HP:0001082)3.33744631
15Abnormal gallbladder physiology (HP:0012438)3.33744631
16Chronic otitis media (HP:0000389)3.31465322
17Loss of speech (HP:0002371)3.28228259
18Interstitial pulmonary disease (HP:0006530)3.22748274
19Recurrent fungal infections (HP:0002841)3.17694103
20Recurrent viral infections (HP:0004429)3.04292946
21Autoimmune thrombocytopenia (HP:0001973)3.03770750
22Agnosia (HP:0010524)2.98412465
23Chronic obstructive pulmonary disease (HP:0006510)2.94252729
24Obstructive lung disease (HP:0006536)2.94252729
25Vasculitis (HP:0002633)2.86915657
26Basal ganglia calcification (HP:0002135)2.83748023
27Recurrent skin infections (HP:0001581)2.78567795
28Cellulitis (HP:0100658)2.77706252
29IgM deficiency (HP:0002850)2.71235698
30Segmental peripheral demyelination/remyelination (HP:0003481)2.69413963
31Recurrent bronchitis (HP:0002837)2.69178657
32Stomatitis (HP:0010280)2.65589278
33Abnormality of mucopolysaccharide metabolism (HP:0011020)2.64462232
34Abnormality of polysaccharide metabolism (HP:0011012)2.64462232
35Abnormality of glycosaminoglycan metabolism (HP:0004371)2.64462232
36Poor head control (HP:0002421)2.63526149
37Aplastic anemia (HP:0001915)2.62888416
38Urinary glycosaminoglycan excretion (HP:0003541)2.61778463
39Mucopolysacchariduria (HP:0008155)2.61778463
40Increased IgE level (HP:0003212)2.61699725
41Nasal polyposis (HP:0100582)2.61091921
42Retrobulbar optic neuritis (HP:0100654)2.59981155
43Optic neuritis (HP:0100653)2.59981155
44Abnormality of T cell physiology (HP:0011840)2.59624275
45Degeneration of anterior horn cells (HP:0002398)2.56162716
46Abnormality of the anterior horn cell (HP:0006802)2.56162716
47Abnormality of the nasal mucosa (HP:0000433)2.56004214
48Hemorrhage of the eye (HP:0011885)2.52165704
49Gingivitis (HP:0000230)2.51345740
50Increased cerebral lipofuscin (HP:0011813)2.51331597
51Amyloidosis (HP:0011034)2.50401944
52Hypergammaglobulinemia (HP:0010702)2.46163169
53Reticulocytopenia (HP:0001896)2.45478529
54Abnormality of T cells (HP:0002843)2.45357073
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.41548379
56Periodontitis (HP:0000704)2.40827691
57Meningitis (HP:0001287)2.36933731
58Long palpebral fissure (HP:0000637)2.36101496
59Abnormality of cells of the erythroid lineage (HP:0012130)2.31625244
60Pustule (HP:0200039)2.30077829
61Peritonitis (HP:0002586)2.29264484
62Encephalitis (HP:0002383)2.27792852
63Increased IgM level (HP:0003496)2.26064979
64Progressive neurologic deterioration (HP:0002344)2.25113160
65Leukocytosis (HP:0001974)2.24857854
66Type I transferrin isoform profile (HP:0003642)2.23556952
67Purpura (HP:0000979)2.22071130
68Upper motor neuron abnormality (HP:0002127)2.22053228
69Urticaria (HP:0001025)2.21046651
70Abnormal number of erythroid precursors (HP:0012131)2.19050792
71Pallor (HP:0000980)2.16366332
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.16350493
73Abnormality of the peritoneum (HP:0002585)2.16050780
74Gingival bleeding (HP:0000225)2.15870650
75* Lymphoma (HP:0002665)2.14120925
76Nausea (HP:0002018)2.13417143
77Lymphopenia (HP:0001888)2.12841253
78Gastrointestinal infarctions (HP:0005244)2.12462747
79Hypophosphatemic rickets (HP:0004912)2.08894409
80Keratoconjunctivitis sicca (HP:0001097)2.07918765
81Osteomyelitis (HP:0002754)2.07393588
82Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.06975115
83Vertebral compression fractures (HP:0002953)2.06007311
84Amaurosis fugax (HP:0100576)2.05929359
85Abnormality of liposaccharide metabolism (HP:0010968)2.05190590
86Abnormality of glycosphingolipid metabolism (HP:0004343)2.05190590
87Abnormality of glycolipid metabolism (HP:0010969)2.05190590
88Deep venous thrombosis (HP:0002625)2.03111330
89Granulocytopenia (HP:0001913)2.01841465
90Pulmonary infiltrates (HP:0002113)2.01763207
91Cervical subluxation (HP:0003308)2.01399236
92Systemic lupus erythematosus (HP:0002725)2.01267155
93IgG deficiency (HP:0004315)2.01015090
94Hemoptysis (HP:0002105)1.99397125
95Chronic mucocutaneous candidiasis (HP:0002728)1.98867426
96Recurrent cutaneous fungal infections (HP:0011370)1.98867426
97Dysostosis multiplex (HP:0000943)1.98115350
98Myocardial infarction (HP:0001658)1.97804169
99Increased serum ferritin (HP:0003281)1.96719676
100Gastrointestinal inflammation (HP:0004386)1.95727982
101Progressive external ophthalmoplegia (HP:0000590)1.94203345
102Anorexia (HP:0002039)1.93775278
103Epistaxis (HP:0000421)1.93272869
104Hepatosplenomegaly (HP:0001433)1.93025646
105* Skin ulcer (HP:0200042)1.92030260
106Neuronal loss in central nervous system (HP:0002529)1.91927344
107Eosinophilia (HP:0001880)1.91901735
108Metaphyseal cupping (HP:0003021)1.91636044
109Multiple enchondromatosis (HP:0005701)1.91289612
110Menorrhagia (HP:0000132)1.90852782
111Abnormal platelet volume (HP:0011876)1.86987589
112Abnormality of the pleura (HP:0002103)1.86759292
113Cutaneous melanoma (HP:0012056)1.86690513
114Abnormal delayed hypersensitivity skin test (HP:0002963)1.86591128
115Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85896446
116Abnormal protein N-linked glycosylation (HP:0012347)1.85896446
117Abnormal protein glycosylation (HP:0012346)1.85896446
118Abnormal glycosylation (HP:0012345)1.85896446
119Gastrointestinal dysmotility (HP:0002579)1.85469993
120Broad face (HP:0000283)1.84721239
121Glomerulopathy (HP:0100820)1.83173900
122Albinism (HP:0001022)1.83059628
123Chest pain (HP:0100749)1.81465469
124Leukopenia (HP:0001882)1.81205142
125Hypertensive crisis (HP:0100735)1.80844664
126Upper limb amyotrophy (HP:0009129)1.80342910
127Distal upper limb amyotrophy (HP:0007149)1.80342910
12811 pairs of ribs (HP:0000878)1.80159915
129* Rough bone trabeculation (HP:0100670)1.80130340
130Abnormality of alkaline phosphatase activity (HP:0004379)1.80116902
131* Neutropenia (HP:0001875)1.80030321
132Hand muscle atrophy (HP:0009130)1.79858739
133Inflammation of the large intestine (HP:0002037)1.79602689
134Spontaneous hematomas (HP:0007420)1.78212753
135Arterial thrombosis (HP:0004420)1.77986502
136Prolonged bleeding time (HP:0003010)1.77621464
137Axonal loss (HP:0003447)1.77169751
138Entropion (HP:0000621)1.76762402
139Abnormality of T cell number (HP:0011839)1.76170038
140Increased density of long bones (HP:0006392)1.75813052
141Polygenic inheritance (HP:0010982)1.75276945
142Gastrointestinal stroma tumor (HP:0100723)1.74744915
143Abnormality of eosinophils (HP:0001879)1.74492828
144* Hypermelanotic macule (HP:0001034)1.73286404
145Emphysema (HP:0002097)1.73042467
146Elevated alkaline phosphatase (HP:0003155)1.72874484
147Keratoconjunctivitis (HP:0001096)1.71670217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.47587344
2ERN13.00156752
3SIK32.82405077
4PIM22.76282010
5TBK12.62902801
6TYK22.49295492
7KIT2.41023216
8ICK2.40444576
9NME22.32614390
10BUB12.29924855
11SMG12.27650636
12TXK2.11865867
13IKBKE2.11446580
14BLK2.08809879
15JAK32.08241752
16ZAP702.01689625
17RPS6KA41.99688022
18ACVR1B1.95383370
19FLT31.94368873
20MAP3K141.93563615
21PRPF4B1.91226132
22IRAK41.85900186
23TAOK11.84207314
24TESK21.82063998
25TGFBR11.78952175
26IRAK31.71492072
27PKN21.70858049
28KSR21.70434912
29STK161.69095585
30FGR1.65800038
31WEE11.56897804
32IKBKB1.56422606
33CDK81.45118980
34DYRK31.44509843
35EEF2K1.43369013
36NEK21.43052948
37BTK1.39932901
38LRRK21.32457662
39STK101.30863959
40CSF1R1.30254341
41KDR1.28815097
42FGFR41.27643597
43MAP2K31.27016111
44SIK11.25908001
45TESK11.21540037
46TEC1.20832707
47EIF2AK11.20608716
48SYK1.17850280
49VRK21.17770518
50MAP3K101.17743816
51PIM11.17210155
52PRKD21.12540141
53BRSK21.09597639
54TNK21.08132543
55CHUK1.05118662
56PAK41.02421259
57MAP3K110.98072112
58CSK0.94726823
59RPS6KB20.94279969
60EIF2AK30.94201716
61CDC70.93414482
62PBK0.93362548
63ARAF0.92989096
64TGFBR20.91455341
65MAP3K10.91056713
66SIK20.88451157
67CDK40.87171016
68ATR0.86923641
69TRIB30.86224077
70HCK0.85842074
71KSR10.85195865
72PASK0.84977191
73LIMK10.84333293
74LYN0.83587972
75CDK70.82699555
76YES10.82484755
77CDK90.82373227
78SCYL20.81529050
79LCK0.81408804
80JAK10.77801853
81MAP3K130.76196722
82CDK120.75015643
83FES0.74926696
84ERBB40.74881964
85MAP3K80.74635715
86STK40.72973832
87PRKG20.72031562
88RAF10.69763184
89DAPK10.69645472
90STK380.69570885
91TSSK60.68964461
92MAP3K60.68875957
93CDC42BPA0.68314257
94PTK60.67228510
95MATK0.67156572
96GRK60.67073371
97TRIM280.64977047
98AURKB0.63028925
99PLK40.62177558
100ABL20.59007184
101PTK20.58632434
102PLK10.58056725
103MARK20.57288050
104ITK0.56452077
105EIF2AK20.56256559
106ILK0.55229462
107ALK0.54884052
108BMPR1B0.53936221
109RIPK40.53464894
110RPS6KA50.52452145
111TAOK20.50040148
112MST1R0.49744934
113BMX0.48301114
114EPHB10.48274726
115BRSK10.47831647
116MOS0.47587837
117EPHA20.46868223
118NTRK10.45747566
119TTN0.45700613
120RPS6KA60.45364081
121CAMKK20.45195091
122MAPKAPK20.45066668
123CLK10.44910881
124EPHA30.44149450
125SRPK10.44122062
126PAK10.43129111
127MAP3K50.42112921
128MAP3K90.41818041
129PDPK10.41502322
130MAP2K60.41303801
131MARK30.40365198
132CSNK1A1L0.39987496
133PIK3CG0.39744401
134JAK20.38911789
135CDK60.38651266
136BRAF0.37494297
137MAP3K30.36017618
138FGFR30.35645760
139RPS6KL10.31677969
140RPS6KC10.31677969
141FYN0.30015039

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.84858704
2DNA replication_Homo sapiens_hsa030302.79388430
3Leishmaniasis_Homo sapiens_hsa051402.54081279
4Proteasome_Homo sapiens_hsa030502.48807599
5Ribosome_Homo sapiens_hsa030102.30102723
6Mismatch repair_Homo sapiens_hsa034302.17078791
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.14973603
8Legionellosis_Homo sapiens_hsa051342.10957956
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.08235969
10Base excision repair_Homo sapiens_hsa034101.94935156
11Antigen processing and presentation_Homo sapiens_hsa046121.91049528
12Measles_Homo sapiens_hsa051621.89038949
13Herpes simplex infection_Homo sapiens_hsa051681.85890232
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85861588
15Graft-versus-host disease_Homo sapiens_hsa053321.73911859
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66458625
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.64420340
18Primary immunodeficiency_Homo sapiens_hsa053401.61377897
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60203441
20Spliceosome_Homo sapiens_hsa030401.56163187
21Pertussis_Homo sapiens_hsa051331.51951534
22Osteoclast differentiation_Homo sapiens_hsa043801.51909935
23RNA polymerase_Homo sapiens_hsa030201.51719630
24Homologous recombination_Homo sapiens_hsa034401.48783550
25Pyrimidine metabolism_Homo sapiens_hsa002401.48763817
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.48489002
27Allograft rejection_Homo sapiens_hsa053301.46553595
28Influenza A_Homo sapiens_hsa051641.46460894
29Other glycan degradation_Homo sapiens_hsa005111.46028086
30Shigellosis_Homo sapiens_hsa051311.42567489
31Tuberculosis_Homo sapiens_hsa051521.35615200
32Nucleotide excision repair_Homo sapiens_hsa034201.34943098
33Malaria_Homo sapiens_hsa051441.34484471
34Apoptosis_Homo sapiens_hsa042101.31247777
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.29493956
36Epstein-Barr virus infection_Homo sapiens_hsa051691.25150552
37RNA transport_Homo sapiens_hsa030131.24810895
38Asthma_Homo sapiens_hsa053101.24757841
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23457159
40Hematopoietic cell lineage_Homo sapiens_hsa046401.22749387
41TNF signaling pathway_Homo sapiens_hsa046681.22706775
42Staphylococcus aureus infection_Homo sapiens_hsa051501.22586650
43Bladder cancer_Homo sapiens_hsa052191.22237234
44One carbon pool by folate_Homo sapiens_hsa006701.20807183
45Vibrio cholerae infection_Homo sapiens_hsa051101.19412429
46p53 signaling pathway_Homo sapiens_hsa041151.18596374
47Cell cycle_Homo sapiens_hsa041101.17907201
48Toxoplasmosis_Homo sapiens_hsa051451.17496761
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16462082
50Endocytosis_Homo sapiens_hsa041441.14210533
51B cell receptor signaling pathway_Homo sapiens_hsa046621.12886006
52Pentose phosphate pathway_Homo sapiens_hsa000301.10833097
53Central carbon metabolism in cancer_Homo sapiens_hsa052301.09460929
54Salmonella infection_Homo sapiens_hsa051321.08306013
55Lysosome_Homo sapiens_hsa041421.05400015
56Thyroid cancer_Homo sapiens_hsa052161.04891796
57Hepatitis B_Homo sapiens_hsa051611.03982610
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02123926
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01592125
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01343906
61Type I diabetes mellitus_Homo sapiens_hsa049400.97977902
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.97128314
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96306454
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93782631
65Non-small cell lung cancer_Homo sapiens_hsa052230.93759859
66Folate biosynthesis_Homo sapiens_hsa007900.89982828
67Viral carcinogenesis_Homo sapiens_hsa052030.89862979
68Non-homologous end-joining_Homo sapiens_hsa034500.88923044
69Rheumatoid arthritis_Homo sapiens_hsa053230.86952837
70RNA degradation_Homo sapiens_hsa030180.85232429
71Hepatitis C_Homo sapiens_hsa051600.82847466
72Protein export_Homo sapiens_hsa030600.82678489
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81478961
74VEGF signaling pathway_Homo sapiens_hsa043700.81289217
75Acute myeloid leukemia_Homo sapiens_hsa052210.80645566
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80554842
77Viral myocarditis_Homo sapiens_hsa054160.78200958
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77461226
79Phagosome_Homo sapiens_hsa041450.76047928
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76002616
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75673762
82Colorectal cancer_Homo sapiens_hsa052100.75497937
83Biosynthesis of amino acids_Homo sapiens_hsa012300.75292213
84Renal cell carcinoma_Homo sapiens_hsa052110.75048638
85T cell receptor signaling pathway_Homo sapiens_hsa046600.74244464
86HTLV-I infection_Homo sapiens_hsa051660.73847808
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.72212913
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70596526
89Fanconi anemia pathway_Homo sapiens_hsa034600.70003521
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67219248
91Chronic myeloid leukemia_Homo sapiens_hsa052200.64587579
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64344571
93Endometrial cancer_Homo sapiens_hsa052130.64296971
94Adherens junction_Homo sapiens_hsa045200.63415577
95Galactose metabolism_Homo sapiens_hsa000520.63245311
96Amoebiasis_Homo sapiens_hsa051460.62062565
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61352771
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60605787
99Systemic lupus erythematosus_Homo sapiens_hsa053220.60516940
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60325679
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.59467677
102Notch signaling pathway_Homo sapiens_hsa043300.59404984
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58922965
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57414336
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57344247
106Selenocompound metabolism_Homo sapiens_hsa004500.56857492
107mRNA surveillance pathway_Homo sapiens_hsa030150.55973028
108African trypanosomiasis_Homo sapiens_hsa051430.55786339
109Basal transcription factors_Homo sapiens_hsa030220.54959339
110Sulfur relay system_Homo sapiens_hsa041220.53703691
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53487879
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53304143
113Caffeine metabolism_Homo sapiens_hsa002320.51971159
114Small cell lung cancer_Homo sapiens_hsa052220.51426589
115N-Glycan biosynthesis_Homo sapiens_hsa005100.50844345
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50414338
117Pancreatic cancer_Homo sapiens_hsa052120.48885721
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.47371803
119Chemokine signaling pathway_Homo sapiens_hsa040620.47365610
120Fructose and mannose metabolism_Homo sapiens_hsa000510.47338155
121Purine metabolism_Homo sapiens_hsa002300.45777803
122Prolactin signaling pathway_Homo sapiens_hsa049170.45377479
123Proteoglycans in cancer_Homo sapiens_hsa052050.45266043
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42936060
125Collecting duct acid secretion_Homo sapiens_hsa049660.40660472
126HIF-1 signaling pathway_Homo sapiens_hsa040660.38970291
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.38489670
128Autoimmune thyroid disease_Homo sapiens_hsa053200.37080367

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