USE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)9.81077204
2SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.62895004
3cotranslational protein targeting to membrane (GO:0006613)8.53936742
4protein targeting to ER (GO:0045047)8.51504779
5translational elongation (GO:0006414)8.40716244
6establishment of protein localization to endoplasmic reticulum (GO:0072599)8.10978853
7protein localization to endoplasmic reticulum (GO:0070972)8.09145721
8viral life cycle (GO:0019058)7.90915202
9cellular protein complex disassembly (GO:0043624)7.71675390
10nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.25861105
11maturation of SSU-rRNA (GO:0030490)6.86568694
12translational initiation (GO:0006413)6.60263932
13protein complex disassembly (GO:0043241)6.51534667
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.46473278
15energy coupled proton transport, down electrochemical gradient (GO:0015985)6.24821905
16ATP synthesis coupled proton transport (GO:0015986)6.24821905
17macromolecular complex disassembly (GO:0032984)6.09617959
18ribosomal large subunit biogenesis (GO:0042273)6.04433837
19protein targeting to membrane (GO:0006612)5.76004844
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.63120141
21respiratory electron transport chain (GO:0022904)5.20538331
22translation (GO:0006412)5.17667814
23electron transport chain (GO:0022900)5.11571441
24nuclear-transcribed mRNA catabolic process (GO:0000956)4.78225436
25behavioral response to nicotine (GO:0035095)4.53681018
26mRNA catabolic process (GO:0006402)4.53265562
27ribonucleoprotein complex biogenesis (GO:0022613)4.07484547
28establishment of protein localization to membrane (GO:0090150)4.06616238
29RNA catabolic process (GO:0006401)4.03809584
30protein complex biogenesis (GO:0070271)3.87176103
31oxidative phosphorylation (GO:0006119)3.84720656
32regulation of cilium movement (GO:0003352)3.80454305
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.73676786
34cellular component biogenesis (GO:0044085)3.73420975
35protein targeting (GO:0006605)3.72849556
36protein-cofactor linkage (GO:0018065)3.65214134
37mitochondrial respiratory chain complex assembly (GO:0033108)3.61599625
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.53639043
39negative regulation of telomere maintenance (GO:0032205)3.52081301
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.49263805
41NADH dehydrogenase complex assembly (GO:0010257)3.49263805
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.49263805
43GTP biosynthetic process (GO:0006183)3.45708002
44ubiquinone biosynthetic process (GO:0006744)3.40817676
45base-excision repair, AP site formation (GO:0006285)3.35811513
46purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.33155976
47water-soluble vitamin biosynthetic process (GO:0042364)3.32417251
48inner mitochondrial membrane organization (GO:0007007)3.31871741
49ATP biosynthetic process (GO:0006754)3.29569683
50preassembly of GPI anchor in ER membrane (GO:0016254)3.28877150
51establishment of protein localization to organelle (GO:0072594)3.27807980
52mannosylation (GO:0097502)3.26878815
53purine nucleoside triphosphate biosynthetic process (GO:0009145)3.25841984
54positive regulation of prostaglandin secretion (GO:0032308)3.22514825
55chaperone-mediated protein transport (GO:0072321)3.22345264
56protein localization to membrane (GO:0072657)3.21488609
57pseudouridine synthesis (GO:0001522)3.20489877
58kynurenine metabolic process (GO:0070189)3.20287704
59protein neddylation (GO:0045116)3.17116753
60protein polyglutamylation (GO:0018095)3.16539838
61indole-containing compound catabolic process (GO:0042436)3.14863714
62indolalkylamine catabolic process (GO:0046218)3.14863714
63tryptophan catabolic process (GO:0006569)3.14863714
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13702901
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13702901
66hydrogen ion transmembrane transport (GO:1902600)3.11217842
67sequestering of actin monomers (GO:0042989)3.08018661
68DNA deamination (GO:0045006)3.07996841
69ribonucleoside triphosphate biosynthetic process (GO:0009201)3.05581545
70ubiquinone metabolic process (GO:0006743)3.02829272
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99154320
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.97873858
73UTP biosynthetic process (GO:0006228)2.91266242
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87897700
75pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.87674653
76CTP biosynthetic process (GO:0006241)2.85520694
77CTP metabolic process (GO:0046036)2.85520694
78termination of RNA polymerase III transcription (GO:0006386)2.84743139
79transcription elongation from RNA polymerase III promoter (GO:0006385)2.84743139
80intracellular protein transmembrane import (GO:0044743)2.84388776
81antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84350935
82L-fucose catabolic process (GO:0042355)2.83916111
83fucose catabolic process (GO:0019317)2.83916111
84L-fucose metabolic process (GO:0042354)2.83916111
85rRNA processing (GO:0006364)2.83496092
86regulation of microtubule-based movement (GO:0060632)2.82307588
87regulation of mitochondrial translation (GO:0070129)2.81295576
88tryptophan metabolic process (GO:0006568)2.80466988
89indolalkylamine metabolic process (GO:0006586)2.80442551
90response to interferon-beta (GO:0035456)2.80347361
91synaptic transmission, cholinergic (GO:0007271)2.79574221
92viral protein processing (GO:0019082)2.79238084
93response to pheromone (GO:0019236)2.79057870
94respiratory chain complex IV assembly (GO:0008535)2.79002690
95anterograde synaptic vesicle transport (GO:0048490)2.78242201
96metallo-sulfur cluster assembly (GO:0031163)2.76973133
97iron-sulfur cluster assembly (GO:0016226)2.76973133
98proton transport (GO:0015992)2.76403006
99epithelial cilium movement (GO:0003351)2.74794777
100regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.74525896
101aerobic respiration (GO:0009060)2.74234050
102protein deneddylation (GO:0000338)2.73929065
103DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.71642510
104tRNA processing (GO:0008033)2.70186369
105axoneme assembly (GO:0035082)2.69838468
106rRNA metabolic process (GO:0016072)2.69675639
107hydrogen transport (GO:0006818)2.69350250
108detection of light stimulus involved in sensory perception (GO:0050962)2.69281722
109detection of light stimulus involved in visual perception (GO:0050908)2.69281722
110gamma-aminobutyric acid transport (GO:0015812)2.65989840
111GPI anchor metabolic process (GO:0006505)2.65460655
112purine deoxyribonucleotide catabolic process (GO:0009155)2.65079027
113cullin deneddylation (GO:0010388)2.64703839
114regulation of cellular amino acid metabolic process (GO:0006521)2.63913145
115positive regulation of fatty acid transport (GO:2000193)2.63730094
116signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.63436712
117intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.63436712
118amine catabolic process (GO:0009310)2.62893848
119cellular biogenic amine catabolic process (GO:0042402)2.62893848
120deoxyribonucleotide catabolic process (GO:0009264)2.61848108
121detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60647018
122cytochrome complex assembly (GO:0017004)2.60207485
123guanosine-containing compound biosynthetic process (GO:1901070)2.59707407
124positive regulation of respiratory burst (GO:0060267)2.58262330
125formation of translation preinitiation complex (GO:0001731)2.58069124
126C-terminal protein lipidation (GO:0006501)2.57562820
127signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.57439859
128signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.57439859
129signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.57439859
130purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.55587681
131quinone biosynthetic process (GO:1901663)2.55166898
132purine deoxyribonucleotide metabolic process (GO:0009151)2.54974838
133protein targeting to mitochondrion (GO:0006626)2.53495157
134autophagic vacuole fusion (GO:0000046)2.52256337
135negative regulation of transcription regulatory region DNA binding (GO:2000678)2.52023885
136proteasome assembly (GO:0043248)2.51295183
137GPI anchor biosynthetic process (GO:0006506)2.50919925
138cellular ketone body metabolic process (GO:0046950)2.49611407
139pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.49609223
140antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.49198523
141antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.49198523
142UTP metabolic process (GO:0046051)2.49175971
143tRNA modification (GO:0006400)2.49056523
144peptidyl-histidine modification (GO:0018202)2.48927285
145signal transduction involved in DNA integrity checkpoint (GO:0072401)2.48397517
146signal transduction involved in DNA damage checkpoint (GO:0072422)2.48397517
147establishment of protein localization to mitochondrion (GO:0072655)2.48313947
148negative regulation of mast cell activation (GO:0033004)2.48257567
149positive regulation of defense response to virus by host (GO:0002230)2.47911504
150platelet dense granule organization (GO:0060155)2.46745870
151nucleoside triphosphate biosynthetic process (GO:0009142)2.45739051
152signal transduction involved in cell cycle checkpoint (GO:0072395)2.45114479
153positive regulation of icosanoid secretion (GO:0032305)2.44492074
154negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.43276855
155energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.41267107
156ATP hydrolysis coupled proton transport (GO:0015991)2.41267107
157cellular response to interferon-beta (GO:0035458)2.41150577
158antigen processing and presentation of endogenous antigen (GO:0019883)2.34762917
159establishment of viral latency (GO:0019043)2.32228251
160viral transcription (GO:0019083)10.5357172
161ribosomal small subunit assembly (GO:0000028)10.0693431
162translational termination (GO:0006415)10.0079770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.45795783
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.94010968
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.86180617
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.44732535
5ZNF274_21170338_ChIP-Seq_K562_Hela3.43403448
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.22606798
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22114187
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.12430380
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.11013410
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.94864916
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79194310
12CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.77229000
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.69135300
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66215802
15VDR_22108803_ChIP-Seq_LS180_Human2.66047964
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61046196
17EZH2_22144423_ChIP-Seq_EOC_Human2.58020808
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.57798022
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53113251
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51563822
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37334979
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.30489809
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29671850
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27915935
25XRN2_22483619_ChIP-Seq_HELA_Human2.22822664
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.10620946
27* VDR_23849224_ChIP-Seq_CD4+_Human2.09735503
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08738311
29TTF2_22483619_ChIP-Seq_HELA_Human2.05478165
30* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.00889565
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00600633
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.99544381
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.99055602
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97537541
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97017052
36IGF1R_20145208_ChIP-Seq_DFB_Human1.95953794
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93612122
38* ELK1_22589737_ChIP-Seq_MCF10A_Human1.90927933
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.90147761
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82423121
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.80187179
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.78029014
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74639884
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73174361
45* YY1_21170310_ChIP-Seq_MESCs_Mouse1.72712585
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72291388
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71785873
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69970634
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68481887
50TP53_22573176_ChIP-Seq_HFKS_Human1.67379400
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67085537
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59199955
53CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.59194795
54* FOXP3_21729870_ChIP-Seq_TREG_Human1.57532701
55* DCP1A_22483619_ChIP-Seq_HELA_Human1.54432525
56IRF1_19129219_ChIP-ChIP_H3396_Human1.54408887
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50662151
58CTCF_18555785_ChIP-Seq_MESCs_Mouse1.49853661
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48750624
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47820280
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.47451947
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44967449
63* ELK1_19687146_ChIP-ChIP_HELA_Human1.44039587
64* REST_21632747_ChIP-Seq_MESCs_Mouse1.43099036
65* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42922028
66EWS_26573619_Chip-Seq_HEK293_Human1.42368430
67* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40093027
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38755247
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36314964
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.36096973
71GBX2_23144817_ChIP-Seq_PC3_Human1.34461209
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.34352642
73ERA_21632823_ChIP-Seq_H3396_Human1.32910835
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32786645
75* SPI1_23547873_ChIP-Seq_NB4_Human1.30795756
76TAF2_19829295_ChIP-Seq_ESCs_Human1.28423016
77* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26135068
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26089157
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.25891975
80REST_18959480_ChIP-ChIP_MESCs_Mouse1.25418190
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24466898
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24152758
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24047964
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24011693
85* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23297779
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.23296960
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23296960
88FUS_26573619_Chip-Seq_HEK293_Human1.23168130
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21735215
90BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.21570691
91MYC_19829295_ChIP-Seq_ESCs_Human1.21160680
92YY1_22570637_ChIP-Seq_MALME-3M_Human1.20168767
93* NCOR_22424771_ChIP-Seq_293T_Human1.19895245
94CTCF_26484167_Chip-Seq_Bcells_Mouse1.18553830
95STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18080441
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16876505
97AR_20517297_ChIP-Seq_VCAP_Human1.16088210
98* VDR_21846776_ChIP-Seq_THP-1_Human1.15628169
99* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14815761
100STAT1_20625510_ChIP-Seq_HELA_Human1.14472713
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13804882
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12584732
103IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12423567
104BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09538590
105FLI1_27457419_Chip-Seq_LIVER_Mouse1.08647359
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07691595
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07134510
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06265785
109* GABP_19822575_ChIP-Seq_HepG2_Human1.06220529
110OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05474974
111* MAF_26560356_Chip-Seq_TH2_Human1.05131878
112SOX2_19829295_ChIP-Seq_ESCs_Human1.04261159
113NANOG_19829295_ChIP-Seq_ESCs_Human1.04261159
114FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03840115
115PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03349927
116MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03267704
117ER_23166858_ChIP-Seq_MCF-7_Human1.03084257
118OCT4_20526341_ChIP-Seq_ESCs_Human1.02811893
119EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02069157
120BCL6_27268052_Chip-Seq_Bcells_Human1.02047135
121TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01163771
122LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01101290
123NANOG_20526341_ChIP-Seq_ESCs_Human1.00543063
124P300_19829295_ChIP-Seq_ESCs_Human0.99975378
125KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99671330
126* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99650256
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99494678
128POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99354872
129CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98830408
130SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98657222
131RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97446305
132MYC_18940864_ChIP-ChIP_HL60_Human0.97394999
133FOXH1_21741376_ChIP-Seq_EPCs_Human0.96311340
134HOXB7_26014856_ChIP-Seq_BT474_Human0.95493656
135ERG_20517297_ChIP-Seq_VCAP_Human0.95369805
136SA1_27219007_Chip-Seq_ERYTHROID_Human0.95223606
137GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94890091
138TET1_21451524_ChIP-Seq_MESCs_Mouse0.94801363
139STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94223657
140P53_21459846_ChIP-Seq_SAOS-2_Human0.94147595
141CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93529669
142* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92655158
143NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92426237
144E2F1_20622854_ChIP-Seq_HELA_Human0.91757644
145EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91697663
146NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91341003
147POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91144113
148HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91094406
149RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91026944
150IRF8_21731497_ChIP-ChIP_J774_Mouse0.90278028
151RAC3_21632823_ChIP-Seq_H3396_Human0.89703884
152* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89420434
153POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89102660
154P300_27268052_Chip-Seq_Bcells_Human0.88637904
155RNF2_27304074_Chip-Seq_NSC_Mouse0.88222459
156TAF15_26573619_Chip-Seq_HEK293_Human0.87642926
157SCL_19346495_ChIP-Seq_HPC-7_Human0.87107217
158ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85927863
159SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85062088
160CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84859702
161PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84000292

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.07003424
2MP0001835_abnormal_antigen_presentation2.79482321
3MP0001968_abnormal_touch/_nociception2.72262249
4MP0009785_altered_susceptibility_to2.59833310
5MP0002148_abnormal_hypersensitivity_rea2.47000505
6MP0002132_abnormal_respiratory_system2.45783744
7MP0004381_abnormal_hair_follicle2.45322305
8MP0002653_abnormal_ependyma_morphology2.43982059
9MP0003724_increased_susceptibility_to2.32404357
10MP0000685_abnormal_immune_system2.31562101
11MP0005671_abnormal_response_to2.29246280
12MP0002163_abnormal_gland_morphology2.28728396
13MP0003646_muscle_fatigue2.26358125
14MP0006036_abnormal_mitochondrial_physio2.15692326
15MP0002254_reproductive_system_inflammat2.11777455
16MP0003763_abnormal_thymus_physiology2.08894958
17MP0005645_abnormal_hypothalamus_physiol2.07462343
18MP0001853_heart_inflammation2.06047620
19MP0003186_abnormal_redox_activity2.00595019
20MP0005551_abnormal_eye_electrophysiolog1.98294718
21MP0003011_delayed_dark_adaptation1.97945289
22MP0005025_abnormal_response_to1.97096946
23MP0001986_abnormal_taste_sensitivity1.93045037
24MP0009046_muscle_twitch1.93016986
25MP0005000_abnormal_immune_tolerance1.92754519
26MP0003195_calcinosis1.91508711
27MP0005387_immune_system_phenotype1.89245173
28MP0001790_abnormal_immune_system1.89245173
29MP0002102_abnormal_ear_morphology1.88641500
30MP0005646_abnormal_pituitary_gland1.85915445
31MP0009745_abnormal_behavioral_response1.85886869
32MP0008877_abnormal_DNA_methylation1.84206783
33MP0001800_abnormal_humoral_immune1.81787840
34MP0001905_abnormal_dopamine_level1.81278863
35MP0003880_abnormal_central_pattern1.80830781
36MP0002272_abnormal_nervous_system1.77025655
37MP0002166_altered_tumor_susceptibility1.75814353
38MP0002723_abnormal_immune_serum1.69644213
39MP0004147_increased_porphyrin_level1.66650732
40MP0005084_abnormal_gallbladder_morpholo1.65441532
41MP0002420_abnormal_adaptive_immunity1.64692861
42MP0002837_dystrophic_cardiac_calcinosis1.64594883
43MP0006276_abnormal_autonomic_nervous1.63327974
44MP0001819_abnormal_immune_cell1.62350801
45MP0002277_abnormal_respiratory_mucosa1.62343465
46MP0003787_abnormal_imprinting1.61536921
47MP0002735_abnormal_chemical_nociception1.60947747
48MP0006035_abnormal_mitochondrial_morpho1.60129074
49MP0001970_abnormal_pain_threshold1.59763713
50MP0004043_abnormal_pH_regulation1.56915753
51MP0005253_abnormal_eye_physiology1.56448256
52MP0002009_preneoplasia1.55642327
53MP0002452_abnormal_antigen_presenting1.54446437
54MP0005379_endocrine/exocrine_gland_phen1.54432804
55MP0003436_decreased_susceptibility_to1.53467734
56MP0002405_respiratory_system_inflammati1.50146995
57MP0003806_abnormal_nucleotide_metabolis1.49239346
58MP0002733_abnormal_thermal_nociception1.48079121
59MP0001501_abnormal_sleep_pattern1.47237151
60MP0002064_seizures1.47028353
61MP0002638_abnormal_pupillary_reflex1.44953451
62MP0002796_impaired_skin_barrier1.42069004
63MP0009333_abnormal_splenocyte_physiolog1.40591577
64MP0004133_heterotaxia1.39125288
65MP0003866_abnormal_defecation1.38572598
66MP0002876_abnormal_thyroid_physiology1.37591850
67MP0001764_abnormal_homeostasis1.36525037
68MP0004510_myositis1.36232315
69MP0005174_abnormal_tail_pigmentation1.34635898
70MP0002006_tumorigenesis1.34433964
71MP0001485_abnormal_pinna_reflex1.33758087
72MP0004742_abnormal_vestibular_system1.32755955
73MP0005075_abnormal_melanosome_morpholog1.30094670
74MP0002572_abnormal_emotion/affect_behav1.27516326
75MP0002938_white_spotting1.25919088
76MP0003638_abnormal_response/metabolism_1.25557182
77MP0003136_yellow_coat_color1.24154150
78MP0000716_abnormal_immune_system1.23456722
79MP0000631_abnormal_neuroendocrine_gland1.22865199
80MP0004885_abnormal_endolymph1.21781514
81MP0000569_abnormal_digit_pigmentation1.21776708
82MP0002419_abnormal_innate_immunity1.20787738
83MP0008789_abnormal_olfactory_epithelium1.19177963
84MP0001529_abnormal_vocalization1.17794627
85MP0002095_abnormal_skin_pigmentation1.17294847
86MP0002557_abnormal_social/conspecific_i1.17180743
87MP0004145_abnormal_muscle_electrophysio1.16421714
88MP0002398_abnormal_bone_marrow1.16262919
89MP0001486_abnormal_startle_reflex1.15056131
90MP0006082_CNS_inflammation1.14800712
91MP0010155_abnormal_intestine_physiology1.14441441
92MP0006072_abnormal_retinal_apoptosis1.14256253
93MP0008872_abnormal_physiological_respon1.13878946
94MP0001845_abnormal_inflammatory_respons1.13836261
95MP0001984_abnormal_olfaction1.13178208
96MP0000465_gastrointestinal_hemorrhage1.11978245
97MP0002722_abnormal_immune_system1.11975388
98MP0003635_abnormal_synaptic_transmissio1.09161677
99MP0000689_abnormal_spleen_morphology1.08948327
100MP0005464_abnormal_platelet_physiology1.06263929
101MP0002067_abnormal_sensory_capabilities1.05476706
102MP0005409_darkened_coat_color1.05242416
103MP0008058_abnormal_DNA_repair1.05235337
104MP0000343_altered_response_to1.03876881
105MP0002063_abnormal_learning/memory/cond1.03203100
106MP0000858_altered_metastatic_potential1.02980907
107MP0008995_early_reproductive_senescence1.02234617
108MP0000749_muscle_degeneration1.01443476
109MP0008469_abnormal_protein_level1.01406902
110MP0002429_abnormal_blood_cell1.01118130
111MP0002933_joint_inflammation1.00793506
112MP0005389_reproductive_system_phenotype1.00113723
113MP0010386_abnormal_urinary_bladder1.00040523
114MP0003718_maternal_effect0.99543178
115MP0005330_cardiomyopathy0.98924350
116MP0001502_abnormal_circadian_rhythm0.98332385
117MP0002234_abnormal_pharynx_morphology0.98088096
118MP0001873_stomach_inflammation0.96998348
119MP0006292_abnormal_olfactory_placode0.96513808
120MP0005423_abnormal_somatic_nervous0.95502650
121MP0002734_abnormal_mechanical_nocicepti0.92330036
122MP0004142_abnormal_muscle_tone0.92257706
123MP0005410_abnormal_fertilization0.89958169
124MP0001542_abnormal_bone_strength0.89169590
125MP0005386_behavior/neurological_phenoty0.88063867
126MP0004924_abnormal_behavior0.88063867
127MP0002060_abnormal_skin_morphology0.87808993
128MP0005501_abnormal_skin_physiology0.86539486
129MP0003137_abnormal_impulse_conducting0.85196639
130MP0000230_abnormal_systemic_arterial0.85084437
131MP0000026_abnormal_inner_ear0.85072722
132MP0008004_abnormal_stomach_pH0.84964526
133MP0003941_abnormal_skin_development0.84316217
134MP0000703_abnormal_thymus_morphology0.83302323
135MP0001851_eye_inflammation0.82894142
136MP0005195_abnormal_posterior_eye0.82744011
137MP0000751_myopathy0.82606637
138MP0002928_abnormal_bile_duct0.81974803
139MP0001963_abnormal_hearing_physiology0.81828791
140MP0002332_abnormal_exercise_endurance0.81380356
141MP0005451_abnormal_body_composition0.81169097
142MP0004947_skin_inflammation0.80810109
143MP0000750_abnormal_muscle_regeneration0.80437710
144MP0000049_abnormal_middle_ear0.79795966
145MP0003121_genomic_imprinting0.78674381
146MP0002752_abnormal_somatic_nervous0.76709417
147MP0009764_decreased_sensitivity_to0.76639835
148MP0002160_abnormal_reproductive_system0.76261031
149MP0005332_abnormal_amino_acid0.75398154
150MP0001348_abnormal_lacrimal_gland0.75312636
151MP0005171_absent_coat_pigmentation0.74961298
152MP0000613_abnormal_salivary_gland0.74705099
153MP0003315_abnormal_perineum_morphology0.73511161
154MP0001324_abnormal_eye_pigmentation0.73197249
155MP0000372_irregular_coat_pigmentation0.73117120
156MP0003786_premature_aging0.72671161
157MP0005310_abnormal_salivary_gland0.72025213
158MP0002138_abnormal_hepatobiliary_system0.71639948
159MP0005636_abnormal_mineral_homeostasis0.71442379
160MP0002229_neurodegeneration0.71035786
161MP0002736_abnormal_nociception_after0.70162858
162MP0001919_abnormal_reproductive_system0.70015550
163MP0001440_abnormal_grooming_behavior0.69843260
164MP0009765_abnormal_xenobiotic_induced0.69606010
165MP0000538_abnormal_urinary_bladder0.69563844
166MP0002693_abnormal_pancreas_physiology0.69379036
167MP0010771_integument_phenotype0.68560007
168MP0009840_abnormal_foam_cell0.67297059
169MP0008875_abnormal_xenobiotic_pharmacok0.64653041
170MP0001216_abnormal_epidermal_layer0.64616959

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.34563220
2Abnormal number of erythroid precursors (HP:0012131)6.24984083
3Acute necrotizing encephalopathy (HP:0006965)5.49657939
4Reticulocytopenia (HP:0001896)5.40347314
5Abnormal mitochondria in muscle tissue (HP:0008316)5.18620737
6Mitochondrial inheritance (HP:0001427)5.13992200
7Macrocytic anemia (HP:0001972)5.06794444
8Hepatocellular necrosis (HP:0001404)4.61428159
9Decreased activity of mitochondrial respiratory chain (HP:0008972)4.59216001
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.59216001
11Acute encephalopathy (HP:0006846)4.47062162
12Pallor (HP:0000980)4.44815817
13Progressive macrocephaly (HP:0004481)4.38367416
14Increased CSF lactate (HP:0002490)4.20877226
15Hepatic necrosis (HP:0002605)4.14981172
16Increased hepatocellular lipid droplets (HP:0006565)3.90940294
17Pancreatic cysts (HP:0001737)3.83076416
18Abnormal hemoglobin (HP:0011902)3.82534360
19Increased intramyocellular lipid droplets (HP:0012240)3.80788714
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.72655181
21Renal Fanconi syndrome (HP:0001994)3.69876949
22Molar tooth sign on MRI (HP:0002419)3.61343757
23Abnormality of midbrain morphology (HP:0002418)3.61343757
24Lipid accumulation in hepatocytes (HP:0006561)3.57022327
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.56248489
26Pancreatic fibrosis (HP:0100732)3.47587455
27Increased muscle lipid content (HP:0009058)3.44337344
28True hermaphroditism (HP:0010459)3.37215945
29Aplasia/Hypoplasia of the sacrum (HP:0008517)3.30379023
30Exercise intolerance (HP:0003546)3.23211699
313-Methylglutaconic aciduria (HP:0003535)3.22614931
32Congenital stationary night blindness (HP:0007642)3.22438503
33Nephronophthisis (HP:0000090)3.20275259
34Hypothermia (HP:0002045)3.14668111
35Lactic acidosis (HP:0003128)3.13252835
36Exertional dyspnea (HP:0002875)3.12535318
37Cerebral edema (HP:0002181)3.08113134
38Respiratory failure (HP:0002878)3.01551710
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.93153985
40Respiratory difficulties (HP:0002880)2.91487847
41Attenuation of retinal blood vessels (HP:0007843)2.76760512
42Type II lissencephaly (HP:0007260)2.73872414
43Optic disc pallor (HP:0000543)2.72305775
44Increased serum lactate (HP:0002151)2.69442943
45Decreased electroretinogram (ERG) amplitude (HP:0000654)2.64944644
46Medial flaring of the eyebrow (HP:0010747)2.64131779
47Abnormal rod and cone electroretinograms (HP:0008323)2.60651697
48Abnormality of the renal medulla (HP:0100957)2.59430824
49Abnormality of alanine metabolism (HP:0010916)2.54954616
50Hyperalaninemia (HP:0003348)2.54954616
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54954616
52Abnormality of the renal cortex (HP:0011035)2.51025415
53Methylmalonic acidemia (HP:0002912)2.48858893
54Aplastic anemia (HP:0001915)2.47428614
55Focal motor seizures (HP:0011153)2.45590647
56Thrombocytosis (HP:0001894)2.45308399
57Abnormal pupillary function (HP:0007686)2.42108802
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40644683
59Leukodystrophy (HP:0002415)2.39739061
60Elevated erythrocyte sedimentation rate (HP:0003565)2.38754980
61Abnormality of the axillary hair (HP:0100134)2.32758961
62Abnormality of secondary sexual hair (HP:0009888)2.32758961
63Fragile nails (HP:0001808)2.31821417
64Abnormality of renal resorption (HP:0011038)2.25988128
65Abolished electroretinogram (ERG) (HP:0000550)2.24832224
66Large for gestational age (HP:0001520)2.22632241
67Progressive microcephaly (HP:0000253)2.22170128
68Renal cortical cysts (HP:0000803)2.21719599
69Parakeratosis (HP:0001036)2.20721479
70Decreased central vision (HP:0007663)2.19781623
71IgM deficiency (HP:0002850)2.18993280
72Cystic liver disease (HP:0006706)2.18224740
73Sclerocornea (HP:0000647)2.17523285
74Nasal polyposis (HP:0100582)2.13306074
75Absent/shortened dynein arms (HP:0200106)2.12590454
76Dynein arm defect of respiratory motile cilia (HP:0012255)2.12590454
77Congenital ichthyosiform erythroderma (HP:0007431)2.12570580
78Hyperventilation (HP:0002883)2.10069119
79Concave nail (HP:0001598)2.08428052
80Broad-based gait (HP:0002136)2.07850396
81Multiple enchondromatosis (HP:0005701)2.07565875
82Stenosis of the external auditory canal (HP:0000402)2.06750606
83Abnormal respiratory epithelium morphology (HP:0012253)2.06629041
84Abnormal respiratory motile cilium morphology (HP:0005938)2.06629041
85Abnormal drinking behavior (HP:0030082)2.06374290
86Polydipsia (HP:0001959)2.06374290
87Delayed CNS myelination (HP:0002188)2.00521958
8811 pairs of ribs (HP:0000878)2.00120548
89Vacuolated lymphocytes (HP:0001922)1.99882141
90Hypoplasia of the pons (HP:0012110)1.98473799
91Abnormal biliary tract physiology (HP:0012439)1.97891590
92Bile duct proliferation (HP:0001408)1.97891590
93Abnormal hair whorl (HP:0010721)1.97573989
94Gait imbalance (HP:0002141)1.97280970
95Type I transferrin isoform profile (HP:0003642)1.94229072
96Abnormality of the pons (HP:0007361)1.94185314
97Partial duplication of thumb phalanx (HP:0009944)1.94182643
98Petechiae (HP:0000967)1.93346828
99Increased IgM level (HP:0003496)1.93221281
100Pendular nystagmus (HP:0012043)1.93040601
101Recurrent bronchitis (HP:0002837)1.92069262
102Inability to walk (HP:0002540)1.91908669
103Abnormality of the nasal mucosa (HP:0000433)1.91013372
104Opisthotonus (HP:0002179)1.90549653
105Congenital hepatic fibrosis (HP:0002612)1.90322723
106Neoplasm of head and neck (HP:0012288)1.89353536
107Esophageal neoplasm (HP:0100751)1.89353536
108Tubular atrophy (HP:0000092)1.89305254
109Chronic hepatic failure (HP:0100626)1.89094952
110Aplasia/hypoplasia of the uterus (HP:0008684)1.88719029
111Muscle fiber atrophy (HP:0100295)1.88314304
112Myositis (HP:0100614)1.88086262
113Depressed nasal ridge (HP:0000457)1.87434502
114Constricted visual fields (HP:0001133)1.87166393
115Palpitations (HP:0001962)1.87115000
116Congenital primary aphakia (HP:0007707)1.86139212
117Recurrent abscess formation (HP:0002722)1.85979836
118Anencephaly (HP:0002323)1.85856437
119Congenital, generalized hypertrichosis (HP:0004540)1.85667147
120Cerebellar dysplasia (HP:0007033)1.83248041
121Nephrogenic diabetes insipidus (HP:0009806)1.82146875
122Ketosis (HP:0001946)1.81653462
123Migraine (HP:0002076)1.81114490
124Microretrognathia (HP:0000308)1.79302408
125Severe muscular hypotonia (HP:0006829)1.79290335
126Stomatitis (HP:0010280)1.76751604
127Polyphagia (HP:0002591)1.76565517
128Hemiparesis (HP:0001269)1.76425920
129Hyperglycinemia (HP:0002154)1.76118786
130Abnormality of macrophages (HP:0004311)1.75184524
131Retinal dysplasia (HP:0007973)1.74983051
132Ragged-red muscle fibers (HP:0003200)1.74700686
133Purpura (HP:0000979)1.74669536
134Lissencephaly (HP:0001339)1.74056828
135Chronic sinusitis (HP:0011109)1.72701787
136Type 2 muscle fiber atrophy (HP:0003554)1.71777838
137Chronic otitis media (HP:0000389)1.69176658
138Erythema (HP:0010783)1.69126420
139Lethargy (HP:0001254)1.68544377
140Dicarboxylic aciduria (HP:0003215)1.67981718
141Abnormality of dicarboxylic acid metabolism (HP:0010995)1.67981718
142Glycosuria (HP:0003076)1.67295293
143Abnormality of urine glucose concentration (HP:0011016)1.67295293
144Myotonia (HP:0002486)1.67040371
145Hypoproteinemia (HP:0003075)1.65640191
146Partial duplication of the phalanx of hand (HP:0009999)1.63475592
147Emotional lability (HP:0000712)1.62978426
148Hypotrichosis (HP:0001006)1.61490888
149Hyperphosphaturia (HP:0003109)1.60544998
150Recurrent bacterial skin infections (HP:0005406)1.58974065
151Onycholysis (HP:0001806)1.58029555
152Eczematoid dermatitis (HP:0000976)1.54019516
153Asplenia (HP:0001746)1.53835630
154Abnormality of reticulocytes (HP:0004312)1.52919028
155Generalized aminoaciduria (HP:0002909)1.52912579
156Woolly hair (HP:0002224)1.52376214
157Muscle hypertrophy of the lower extremities (HP:0008968)1.48486799
158Renal tubular dysfunction (HP:0000124)1.48193211
159Methylmalonic aciduria (HP:0012120)1.46428147
160CNS demyelination (HP:0007305)1.46326139
161Pancytopenia (HP:0001876)1.44663942
162Absent thumb (HP:0009777)1.44608189

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.49034813
2VRK23.05102080
3MAP3K123.02246261
4ZAK2.89622693
5FRK2.85133351
6NUAK12.78415457
7MAP4K12.70018134
8MST42.68086282
9STK162.68019405
10MYLK2.59156309
11WNK42.58534330
12PIM22.38395259
13MAP4K22.36780663
14BMPR1B2.14143948
15TAOK32.13679844
16NME12.11281775
17MAPKAPK52.04300099
18BCKDK1.96036971
19DAPK21.91973899
20TGFBR11.82946784
21LRRK21.82896928
22GRK71.80086171
23VRK11.77820221
24WNK31.74361020
25MAP2K71.72471309
26INSRR1.70093620
27CDK191.67871455
28RPS6KB21.65256263
29MAPKAPK31.64666763
30PINK11.62896931
31CAMKK21.62495276
32IKBKE1.61712347
33MAPK131.61473560
34TXK1.58452067
35TLK11.58369275
36IKBKB1.54763876
37TEC1.52036912
38MUSK1.46901429
39TYK21.46524523
40ZAP701.44279833
41MAP3K41.43844909
42ADRBK21.42423676
43ARAF1.38142311
44BTK1.37668709
45BLK1.37339889
46TBK11.37211844
47MAPK151.29881386
48MAP2K21.27268387
49ILK1.26591965
50SYK1.23926924
51MST1R1.20267307
52RPS6KA51.18461052
53GRK51.12447751
54MAP3K31.09600374
55CASK1.08894365
56DAPK31.06826233
57PHKG11.04681439
58IRAK41.03490200
59STK241.01422797
60IRAK30.99345234
61PRKCG0.99126315
62SIK20.98285753
63CSNK1G30.96616244
64RPS6KA60.95657749
65RPS6KA40.94094683
66TIE10.92017992
67BUB10.89653555
68KIT0.89350913
69PKN10.89322182
70MARK10.87875459
71MAP2K60.87187794
72RPS6KC10.86251452
73RPS6KL10.86251452
74PBK0.84821650
75CSNK1G20.84587326
76KDR0.83668833
77PRKCQ0.82610978
78DYRK30.82454094
79FLT30.82066201
80LCK0.81850311
81CAMKK10.81259839
82CSNK1G10.80236778
83TSSK60.78474745
84NLK0.77741654
85ABL20.77579366
86OBSCN0.77313722
87GRK60.75327664
88MAP3K140.73967424
89PAK30.71127417
90MAP3K110.70978331
91MAPK40.70774512
92EEF2K0.70714915
93PRKCI0.70583217
94TESK20.69955139
95TNK20.69350826
96LMTK20.69315296
97PRKCE0.67195193
98CSNK1A1L0.66502404
99ACVR1B0.65143325
100ADRBK10.60386848
101DAPK10.60137867
102LYN0.58619588
103PASK0.58331535
104PIM10.56732704
105CSF1R0.56573336
106CAMK10.56183502
107PIK3CG0.55242160
108PRKACA0.54888127
109TRPM70.54673874
110GRK10.54250475
111JAK30.52828932
112ITK0.52598800
113MATK0.51419331
114MAPK120.50825329
115MAP2K30.50370764
116HIPK20.50002961
117MAPKAPK20.49634355
118PNCK0.48361485
119CAMK2A0.47540809
120IRAK10.45984887
121CSNK2A10.45777458
122TESK10.45632484
123PAK60.45540130
124CCNB10.45165951
125LIMK10.45099933
126PRKCD0.44932583
127PTK2B0.44906866
128BRSK20.44544179
129ERN10.43728173
130OXSR10.43479597
131PLK20.43403162
132FES0.42503256
133CSNK2A20.41731145
134PRKCA0.41448420
135STK390.41352919
136DYRK20.41090903
137TGFBR20.40954180
138PDK20.39490187
139BRAF0.38836911
140MKNK20.38595926
141CAMK2G0.38352217
142RPS6KA20.38207026
143PRKG20.37602605
144CSNK1A10.36922667
145MOS0.36127936
146NTRK30.35871447
147SRPK10.35834165
148CDK80.35709930
149HCK0.35399366
150PHKG20.34626028
151AURKA0.31875355
152EPHA40.30942468
153MKNK10.30777999

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030108.19406939
2Oxidative phosphorylation_Homo sapiens_hsa001905.29608527
3Parkinsons disease_Homo sapiens_hsa050124.59485223
4Alzheimers disease_Homo sapiens_hsa050103.33309002
5Proteasome_Homo sapiens_hsa030503.31325834
6Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.16219521
7Huntingtons disease_Homo sapiens_hsa050163.08280192
8Protein export_Homo sapiens_hsa030602.36465863
9RNA polymerase_Homo sapiens_hsa030202.29144190
10Phototransduction_Homo sapiens_hsa047442.14996300
11Cardiac muscle contraction_Homo sapiens_hsa042601.86573401
12Nitrogen metabolism_Homo sapiens_hsa009101.69040505
13Butanoate metabolism_Homo sapiens_hsa006501.65735647
14Sulfur relay system_Homo sapiens_hsa041221.58473037
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52949301
16Primary immunodeficiency_Homo sapiens_hsa053401.51838221
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38272208
18Pyrimidine metabolism_Homo sapiens_hsa002401.37001316
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31273484
20Fatty acid elongation_Homo sapiens_hsa000621.28602117
21Nicotine addiction_Homo sapiens_hsa050331.27587387
22Tryptophan metabolism_Homo sapiens_hsa003801.27531478
23Collecting duct acid secretion_Homo sapiens_hsa049661.19701340
24Regulation of autophagy_Homo sapiens_hsa041401.12678583
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08222424
26Phenylalanine metabolism_Homo sapiens_hsa003601.06650438
27Fanconi anemia pathway_Homo sapiens_hsa034601.04908951
28Selenocompound metabolism_Homo sapiens_hsa004501.04590950
29Arachidonic acid metabolism_Homo sapiens_hsa005901.02081239
30Folate biosynthesis_Homo sapiens_hsa007901.01812969
31Graft-versus-host disease_Homo sapiens_hsa053321.00836807
32Glutathione metabolism_Homo sapiens_hsa004800.97399569
33Spliceosome_Homo sapiens_hsa030400.96938981
34Type I diabetes mellitus_Homo sapiens_hsa049400.96847562
35Maturity onset diabetes of the young_Homo sapiens_hsa049500.96792470
36Allograft rejection_Homo sapiens_hsa053300.96516416
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95629883
38Rheumatoid arthritis_Homo sapiens_hsa053230.93726278
39Mismatch repair_Homo sapiens_hsa034300.91902806
40Sulfur metabolism_Homo sapiens_hsa009200.91781783
41DNA replication_Homo sapiens_hsa030300.91080008
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90574746
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90412966
44Hematopoietic cell lineage_Homo sapiens_hsa046400.86712674
45Olfactory transduction_Homo sapiens_hsa047400.83586288
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83300634
47Other glycan degradation_Homo sapiens_hsa005110.82665826
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.82049778
49Nucleotide excision repair_Homo sapiens_hsa034200.82029242
50Base excision repair_Homo sapiens_hsa034100.80885946
51Tyrosine metabolism_Homo sapiens_hsa003500.80288240
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78394342
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75312921
54Chemical carcinogenesis_Homo sapiens_hsa052040.74868615
55Histidine metabolism_Homo sapiens_hsa003400.73522804
56Metabolic pathways_Homo sapiens_hsa011000.72745062
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.72139690
58Morphine addiction_Homo sapiens_hsa050320.72043067
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71509134
60One carbon pool by folate_Homo sapiens_hsa006700.70299515
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69118677
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68465804
63Linoleic acid metabolism_Homo sapiens_hsa005910.67997444
64Taste transduction_Homo sapiens_hsa047420.67708449
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.66307061
66Purine metabolism_Homo sapiens_hsa002300.65305998
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64264476
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60884939
69GABAergic synapse_Homo sapiens_hsa047270.60162383
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60146647
71Antigen processing and presentation_Homo sapiens_hsa046120.59077544
72Basal transcription factors_Homo sapiens_hsa030220.57627480
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.57564312
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57271446
75Autoimmune thyroid disease_Homo sapiens_hsa053200.56766465
76Homologous recombination_Homo sapiens_hsa034400.55573225
77Vibrio cholerae infection_Homo sapiens_hsa051100.54979501
78Asthma_Homo sapiens_hsa053100.54620818
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54105957
80* SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54007543
81Insulin secretion_Homo sapiens_hsa049110.53800113
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51707423
83Steroid biosynthesis_Homo sapiens_hsa001000.50288926
84Pyruvate metabolism_Homo sapiens_hsa006200.50269822
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49192228
86Sphingolipid metabolism_Homo sapiens_hsa006000.46602657
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46072000
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45600596
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45469656
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.45180947
91Caffeine metabolism_Homo sapiens_hsa002320.43951698
92Non-homologous end-joining_Homo sapiens_hsa034500.42830921
93Galactose metabolism_Homo sapiens_hsa000520.41745182
94Malaria_Homo sapiens_hsa051440.41276527
95Peroxisome_Homo sapiens_hsa041460.41246470
96RNA degradation_Homo sapiens_hsa030180.39706181
97Propanoate metabolism_Homo sapiens_hsa006400.39191448
98Mineral absorption_Homo sapiens_hsa049780.38598355
99Synaptic vesicle cycle_Homo sapiens_hsa047210.36607921
100Phagosome_Homo sapiens_hsa041450.35995876
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35820499
102Epstein-Barr virus infection_Homo sapiens_hsa051690.35374017
103Leishmaniasis_Homo sapiens_hsa051400.35298058
104Pentose phosphate pathway_Homo sapiens_hsa000300.33567957
105Measles_Homo sapiens_hsa051620.32866952
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.32807683
107Arginine and proline metabolism_Homo sapiens_hsa003300.31054239
108Circadian entrainment_Homo sapiens_hsa047130.30797922
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30600087
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29843466
111Ovarian steroidogenesis_Homo sapiens_hsa049130.29807111
112Serotonergic synapse_Homo sapiens_hsa047260.29721156
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.29365462
114Pertussis_Homo sapiens_hsa051330.29055949
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27788284
116Calcium signaling pathway_Homo sapiens_hsa040200.27208270
117Glutamatergic synapse_Homo sapiens_hsa047240.26814474
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26377011
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26140813
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25148986
121Carbon metabolism_Homo sapiens_hsa012000.25076066
122Fructose and mannose metabolism_Homo sapiens_hsa000510.25020411
123Salivary secretion_Homo sapiens_hsa049700.24135565
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23785688
125beta-Alanine metabolism_Homo sapiens_hsa004100.23672249
126Ether lipid metabolism_Homo sapiens_hsa005650.23203610
127Legionellosis_Homo sapiens_hsa051340.23055934
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21439282
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20130729
130Systemic lupus erythematosus_Homo sapiens_hsa053220.19928227
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19905465
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.17739635
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16724484
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.16622931
135Retinol metabolism_Homo sapiens_hsa008300.15851085

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