USF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.64420659
2negative regulation of cell killing (GO:0031342)5.64420659
3positive regulation of gamma-delta T cell activation (GO:0046645)5.30069249
4positive regulation by symbiont of host defense response (GO:0052509)5.27273468
5modulation by symbiont of host defense response (GO:0052031)5.27273468
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.27273468
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.27273468
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.27273468
9modulation by symbiont of host immune response (GO:0052553)5.27273468
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.11871280
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.08847022
12antigen processing and presentation of endogenous antigen (GO:0019883)5.03988673
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.77184825
14macrophage activation involved in immune response (GO:0002281)4.56478901
15neutrophil activation involved in immune response (GO:0002283)4.47689899
16detection of other organism (GO:0098543)4.43070412
17negative regulation of histone methylation (GO:0031061)4.40953719
18DNA unwinding involved in DNA replication (GO:0006268)4.40363245
19* viral transcription (GO:0019083)4.34144031
20detection of bacterium (GO:0016045)4.30029557
21negative regulation of interleukin-12 production (GO:0032695)4.28400232
22protein-DNA complex disassembly (GO:0032986)4.26078713
23nucleosome disassembly (GO:0006337)4.26078713
24histone H2A acetylation (GO:0043968)4.25347186
25peptidyl-arginine omega-N-methylation (GO:0035247)4.23297916
26negative regulation of erythrocyte differentiation (GO:0045647)4.23127045
27response to peptidoglycan (GO:0032494)4.20175503
28translational termination (GO:0006415)4.14874744
29maturation of SSU-rRNA (GO:0030490)4.12404621
30somatic hypermutation of immunoglobulin genes (GO:0016446)4.05820159
31somatic diversification of immune receptors via somatic mutation (GO:0002566)4.05820159
32ribosomal small subunit assembly (GO:0000028)4.02638960
33regulation of interferon-beta biosynthetic process (GO:0045357)4.02042192
34immunoglobulin mediated immune response (GO:0016064)4.02006458
35ribosomal small subunit biogenesis (GO:0042274)4.01410144
36formation of translation preinitiation complex (GO:0001731)3.91209104
37regulation of B cell receptor signaling pathway (GO:0050855)3.90101500
38translational elongation (GO:0006414)3.86887619
39regulation of gene silencing by RNA (GO:0060966)3.82007549
40regulation of posttranscriptional gene silencing (GO:0060147)3.82007549
41regulation of gene silencing by miRNA (GO:0060964)3.82007549
42DNA damage response, detection of DNA damage (GO:0042769)3.79708917
43regulation of histone H3-K9 methylation (GO:0051570)3.78539615
44translational initiation (GO:0006413)3.77839058
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.75075992
46regulation of gamma-delta T cell activation (GO:0046643)3.74086379
47peptidyl-arginine N-methylation (GO:0035246)3.71911485
48peptidyl-arginine methylation (GO:0018216)3.71911485
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.70385793
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.70385793
51detection of external biotic stimulus (GO:0098581)3.68830635
52germinal center formation (GO:0002467)3.63400195
53nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.62869181
54histone arginine methylation (GO:0034969)3.61479700
55positive regulation of mast cell activation (GO:0033005)3.60912311
56regulation of mast cell degranulation (GO:0043304)3.58857550
57negative regulation of RNA splicing (GO:0033119)3.56178356
58negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.55912877
59protein complex disassembly (GO:0043241)3.55647064
60response to muramyl dipeptide (GO:0032495)3.54871084
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.54049138
62response to host immune response (GO:0052572)3.54049138
63cellular extravasation (GO:0045123)3.53604524
64NIK/NF-kappaB signaling (GO:0038061)3.48635088
65ribosome biogenesis (GO:0042254)3.46013700
66detection of biotic stimulus (GO:0009595)3.45197975
67negative regulation of lymphocyte mediated immunity (GO:0002707)3.43493767
68ribonucleoprotein complex biogenesis (GO:0022613)3.42932009
69cellular protein complex disassembly (GO:0043624)3.40271529
70SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39160913
71leukocyte aggregation (GO:0070486)3.38749418
72detection of molecule of bacterial origin (GO:0032490)3.37935983
73regulation of myeloid leukocyte mediated immunity (GO:0002886)3.37381724
74protein localization to kinetochore (GO:0034501)3.36588788
75regulation of chromatin binding (GO:0035561)3.36235502
76viral life cycle (GO:0019058)3.35529777
77spliceosomal snRNP assembly (GO:0000387)3.35488561
78regulation of leukocyte degranulation (GO:0043300)3.35187569
79RNA splicing, via transesterification reactions (GO:0000375)3.34737096
80mRNA splicing, via spliceosome (GO:0000398)3.34356950
81RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.34356950
82positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.33893572
83microglial cell activation (GO:0001774)3.33875907
84macromolecular complex disassembly (GO:0032984)3.33734812
85regulation of T-helper 2 cell differentiation (GO:0045628)3.33327353
86response to type I interferon (GO:0034340)3.32752194
87negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.32375033
88DNA replication-dependent nucleosome organization (GO:0034723)3.31580404
89DNA replication-dependent nucleosome assembly (GO:0006335)3.31580404
90cellular response to type I interferon (GO:0071357)3.31114674
91type I interferon signaling pathway (GO:0060337)3.31114674
92cotranslational protein targeting to membrane (GO:0006613)3.30472941
93B cell receptor signaling pathway (GO:0050853)3.29901989
94protein targeting to ER (GO:0045047)3.29513346
95regulation of mast cell activation (GO:0033003)3.29242324
96nucleobase biosynthetic process (GO:0046112)3.28247745
97positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.27952746
98response to host (GO:0075136)3.26464739
99response to host defenses (GO:0052200)3.26464739
100response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.26464739
101positive thymic T cell selection (GO:0045059)3.26381277
102regulation of mast cell activation involved in immune response (GO:0033006)3.26108424
103regulation of helicase activity (GO:0051095)3.26095450
104neutrophil activation (GO:0042119)3.25558327
105positive regulation of mast cell degranulation (GO:0043306)3.22967856
106positive regulation of mast cell activation involved in immune response (GO:0033008)3.22967856
107negative regulation of leukocyte mediated immunity (GO:0002704)3.21315072
108respiratory burst (GO:0045730)3.20745098
109viral mRNA export from host cell nucleus (GO:0046784)3.20378789
110negative regulation of type 2 immune response (GO:0002829)3.19192216
111DNA strand elongation involved in DNA replication (GO:0006271)3.19043834
112macrophage activation (GO:0042116)3.18340583
113positive regulation of B cell differentiation (GO:0045579)3.18297505
114myeloid cell activation involved in immune response (GO:0002275)3.17530306
115positive regulation of interferon-alpha production (GO:0032727)3.16765320
116regulation of gamma-delta T cell differentiation (GO:0045586)3.14086900
117negative regulation of T cell mediated immunity (GO:0002710)3.12856559
118DNA replication initiation (GO:0006270)3.10602652
119interferon-gamma-mediated signaling pathway (GO:0060333)3.10365464
120establishment of protein localization to endoplasmic reticulum (GO:0072599)3.10277193
121negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.09787057
122negative regulation of T-helper cell differentiation (GO:0045623)3.09787057
123granulocyte activation (GO:0036230)3.09419345
124antigen processing and presentation via MHC class Ib (GO:0002475)3.08901851
125regulation of dendritic cell antigen processing and presentation (GO:0002604)3.08758444
126DNA strand elongation (GO:0022616)3.08187703
127ribosomal large subunit biogenesis (GO:0042273)3.07241332
128tolerance induction (GO:0002507)3.04784228
129leukocyte migration involved in inflammatory response (GO:0002523)3.03769278
130B cell mediated immunity (GO:0019724)3.03479058
131regulation of interferon-alpha production (GO:0032647)3.03311329
132negative thymic T cell selection (GO:0045060)3.03232606
133histone H4-K12 acetylation (GO:0043983)3.02543284
134regulation of antigen processing and presentation (GO:0002577)3.01246924
135regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.00926667
136pre-miRNA processing (GO:0031054)3.00727539
137defense response to protozoan (GO:0042832)3.00434939
138protein localization to endoplasmic reticulum (GO:0070972)2.99749189
139regulation of T cell tolerance induction (GO:0002664)2.99183118
140histone H4-K5 acetylation (GO:0043981)2.98633086
141histone H4-K8 acetylation (GO:0043982)2.98633086
142nuclear-transcribed mRNA catabolic process (GO:0000956)2.98162747
143regulation of B cell differentiation (GO:0045577)2.97563734
144positive regulation of antigen processing and presentation (GO:0002579)2.95837374
145ncRNA 3-end processing (GO:0043628)2.95529882
146purine nucleobase biosynthetic process (GO:0009113)2.94933648
147cullin deneddylation (GO:0010388)2.94612953
148activated T cell proliferation (GO:0050798)2.91829516
149interferon-gamma secretion (GO:0072643)2.91556977
150negative regulation of mRNA processing (GO:0050686)2.89092673
151positive regulation of cellular amide metabolic process (GO:0034250)2.89059217
152termination of RNA polymerase II transcription (GO:0006369)2.88035367
153regulation of regulated secretory pathway (GO:1903305)2.86926812
154snRNA metabolic process (GO:0016073)2.86394520
155spliceosomal complex assembly (GO:0000245)2.86249592
156regulation of tolerance induction (GO:0002643)2.86099065
157establishment of integrated proviral latency (GO:0075713)2.85141451
158lipopolysaccharide-mediated signaling pathway (GO:0031663)2.84920333
159neutrophil mediated immunity (GO:0002446)2.84786286
160negative T cell selection (GO:0043383)2.84277321
161telomere maintenance via semi-conservative replication (GO:0032201)2.84258939
162positive regulation of RNA splicing (GO:0033120)2.83977658
163production of molecular mediator involved in inflammatory response (GO:0002532)2.83673989
164regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.82829169
165regulation of natural killer cell mediated immunity (GO:0002715)2.82829169
166regulation of telomere maintenance via telomerase (GO:0032210)2.81635500
167mRNA catabolic process (GO:0006402)2.81276506
168ribosome assembly (GO:0042255)2.80030917
169T cell selection (GO:0045058)2.79402393
170transcription-coupled nucleotide-excision repair (GO:0006283)2.79297544
171negative regulation of innate immune response (GO:0045824)2.78985941
172positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.78592011
173response to interleukin-15 (GO:0070672)2.78505662
174negative regulation of histone modification (GO:0031057)2.77547105
175IMP biosynthetic process (GO:0006188)2.77522724
176RNA catabolic process (GO:0006401)2.77175678
177regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.75636311
178regulation of type 2 immune response (GO:0002828)2.75330564
179rRNA processing (GO:0006364)2.72924536
180termination of RNA polymerase III transcription (GO:0006386)2.70123655
181transcription elongation from RNA polymerase III promoter (GO:0006385)2.70123655
182nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.69676636
183protein deneddylation (GO:0000338)2.69329019
184RNA splicing (GO:0008380)2.67788551
185snRNA processing (GO:0016180)2.66967426
186negative regulation of telomerase activity (GO:0051974)2.65461935
187negative regulation of chromatin modification (GO:1903309)2.64017137
188peptidyl-arginine modification (GO:0018195)2.63272852
189telomere maintenance via telomere lengthening (GO:0010833)2.63100908
190regulation of hippo signaling (GO:0035330)2.62922243
191pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.62679948
192rRNA metabolic process (GO:0016072)2.60742408
193histone H2A monoubiquitination (GO:0035518)2.60130857
194IMP metabolic process (GO:0046040)2.60037350
195RNA export from nucleus (GO:0006405)2.59144327
196ribonucleoprotein complex assembly (GO:0022618)2.58660349
197negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.58540414
198DNA duplex unwinding (GO:0032508)2.58083334
199DNA-templated transcription, termination (GO:0006353)2.55672494
200postreplication repair (GO:0006301)2.54180394

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.45468047
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.99645556
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.47731799
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.45062974
5* IRF8_21731497_ChIP-ChIP_J774_Mouse3.25534751
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23108504
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.22889651
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.13623649
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.07456361
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.04173038
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99899104
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.98729198
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85296326
14MYC_22102868_ChIP-Seq_BL_Human2.81929903
15VDR_24763502_ChIP-Seq_THP-1_Human2.71819723
16* IRF8_27001747_Chip-Seq_BMDM_Mouse2.65297555
17* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.61997270
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56937054
19* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.53852006
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46970166
21* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46816581
22* ETS1_20019798_ChIP-Seq_JURKAT_Human2.42888044
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40338764
24MAF_26560356_Chip-Seq_TH1_Human2.35419516
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35150950
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.34417843
27XRN2_22483619_ChIP-Seq_HELA_Human2.34276411
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.27272694
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.25811065
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25712352
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.25450296
32* CIITA_25753668_ChIP-Seq_RAJI_Human2.20734531
33RUNX_20019798_ChIP-Seq_JUKART_Human2.19729319
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19030208
35* EST1_17652178_ChIP-ChIP_JURKAT_Human2.18846457
36E2F4_17652178_ChIP-ChIP_JURKAT_Human2.18641444
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17110452
38BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13357972
39* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.12333046
40MYB_21317192_ChIP-Seq_ERMYB_Mouse2.09596138
41* SPI1_23547873_ChIP-Seq_NB4_Human2.07997644
42* RUNX1_22412390_ChIP-Seq_EML_Mouse2.07856555
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07193599
44SCL_19346495_ChIP-Seq_HPC-7_Human2.05767345
45* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.05480753
46* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02623725
47NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02511197
48* GABP_17652178_ChIP-ChIP_JURKAT_Human2.01847172
49SPI1_23127762_ChIP-Seq_K562_Human2.01265363
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.00263341
51KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.00263341
52KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.00263341
53* LXR_22292898_ChIP-Seq_THP-1_Human1.97517780
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.94333401
55VDR_21846776_ChIP-Seq_THP-1_Human1.93126429
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92134483
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91764508
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.88809660
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.86686846
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86529295
61VDR_23849224_ChIP-Seq_CD4+_Human1.83257212
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83056294
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80586105
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80388635
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.78990164
66* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78520182
67MYB_26560356_Chip-Seq_TH2_Human1.75817721
68* YY1_21170310_ChIP-Seq_MESCs_Mouse1.73954026
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73259003
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72860690
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72517982
72* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72168025
73MYB_26560356_Chip-Seq_TH1_Human1.69812304
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69450124
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.69281470
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63771515
77FOXP3_21729870_ChIP-Seq_TREG_Human1.60912397
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.60273891
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.60122002
80GABP_19822575_ChIP-Seq_HepG2_Human1.58093636
81* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57636873
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56386063
83* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54697625
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53434193
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52438130
86* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51933098
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51299642
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.51258424
89* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.49357348
90* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48935676
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.47562666
92* TTF2_22483619_ChIP-Seq_HELA_Human1.47234774
93KDM2B_26808549_Chip-Seq_JURKAT_Human1.46592419
94* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44491636
95VDR_24787735_ChIP-Seq_THP-1_Human1.42868557
96ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41440579
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39621560
98* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37955485
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37160110
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37081043
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36718801
102HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36545178
103* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36319445
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35556756
105KDM5A_27292631_Chip-Seq_BREAST_Human1.33756501
106CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33542512
107* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32473013
108* NANOG_21062744_ChIP-ChIP_HESCs_Human1.31697933
109* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31251260
110IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30202513
111DCP1A_22483619_ChIP-Seq_HELA_Human1.29610065
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28909422
113* GATA3_27048872_Chip-Seq_THYMUS_Human1.27450543
114* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27435191
115RACK7_27058665_Chip-Seq_MCF-7_Human1.26979203
116* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26970287
117KDM2B_26808549_Chip-Seq_K562_Human1.26429944
118KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25566974
119* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25364636
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24736906
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24409394
122* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22056688
123TFEB_21752829_ChIP-Seq_HELA_Human1.21918725
124TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21723633
125* PU_27001747_Chip-Seq_BMDM_Mouse1.21127585
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20717365
127* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19796426
128SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.19560918
129EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18384384
130SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18337226
131* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17709409
132* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17403878
133* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17359327
134* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16984966
135GATA1_19941826_ChIP-Seq_K562_Human1.16911517
136BCL6_27268052_Chip-Seq_Bcells_Human1.14917195
137SA1_27219007_Chip-Seq_ERYTHROID_Human1.13472755
138KDM2B_26808549_Chip-Seq_DND41_Human1.13105071
139E2F1_21310950_ChIP-Seq_MCF-7_Human1.12356612
140NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12204584
141BCOR_27268052_Chip-Seq_Bcells_Human1.10920830
142* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10603571
143KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09905368
144SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09723385
145SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08766956
146SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07444213
147UTX_26944678_Chip-Seq_JUKART_Human1.06418563
148LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06266035
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05807695
150PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05267058
151ELF1_20517297_ChIP-Seq_JURKAT_Human1.05071889
152* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04394411
153P68_20966046_ChIP-Seq_HELA_Human1.04260019
154ELK3_25401928_ChIP-Seq_HUVEC_Human1.02699046
155* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02648893
156* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02609664
157STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01864351
158CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00665024
159TCF7_22412390_ChIP-Seq_EML_Mouse1.00188618
160ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99473555
161PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99178626
162ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98624224
163NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.97994883
164MAF_26560356_Chip-Seq_TH2_Human0.97976857
165VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97933118
166TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97527963
167DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96707602
168* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96484149
169* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96390194
170SOX2_18692474_ChIP-Seq_MESCs_Mouse0.96299061
171NCOR1_26117541_ChIP-Seq_K562_Human0.96132445
172E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94956096
173FOXP1_21924763_ChIP-Seq_HESCs_Human0.94444280
174SMAD_19615063_ChIP-ChIP_OVARY_Human0.94416905
175CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94052765
176* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93222878
177PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92439562
178EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90977625
179TET1_21451524_ChIP-Seq_MESCs_Mouse0.89950549
180RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89684719
181* GATA2_19941826_ChIP-Seq_K562_Human0.89420169
182GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87338717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.59885571
2MP0003436_decreased_susceptibility_to4.10285459
3MP0003693_abnormal_embryo_hatching3.94843577
4MP0004957_abnormal_blastocyst_morpholog3.64657769
5MP0001835_abnormal_antigen_presentation3.57950538
6MP0001348_abnormal_lacrimal_gland3.50193623
7MP0003111_abnormal_nucleus_morphology3.31943452
8MP0003077_abnormal_cell_cycle3.19712099
9MP0005671_abnormal_response_to2.99950729
10MP0002419_abnormal_innate_immunity2.97527983
11MP0010094_abnormal_chromosome_stability2.95572876
12MP0005387_immune_system_phenotype2.90191686
13MP0001790_abnormal_immune_system2.90191686
14MP0005000_abnormal_immune_tolerance2.89223561
15MP0005025_abnormal_response_to2.80205853
16MP0006292_abnormal_olfactory_placode2.75923518
17MP0008007_abnormal_cellular_replicative2.64621341
18MP0004133_heterotaxia2.63105166
19MP0009785_altered_susceptibility_to2.62055960
20MP0002148_abnormal_hypersensitivity_rea2.49789661
21MP0008877_abnormal_DNA_methylation2.49099392
22MP0001730_embryonic_growth_arrest2.46600275
23MP0008058_abnormal_DNA_repair2.45884989
24MP0003300_gastrointestinal_ulcer2.35499806
25MP0006082_CNS_inflammation2.34721740
26MP0003172_abnormal_lysosome_physiology2.29575785
27MP0003119_abnormal_digestive_system2.23470409
28MP0005058_abnormal_lysosome_morphology2.21375547
29MP0002653_abnormal_ependyma_morphology2.14112821
30MP0001533_abnormal_skeleton_physiology2.11100054
31MP0000350_abnormal_cell_proliferation2.10823489
32MP0004947_skin_inflammation2.00885278
33MP0008932_abnormal_embryonic_tissue1.98722480
34MP0010155_abnormal_intestine_physiology1.89009758
35MP0002405_respiratory_system_inflammati1.87409912
36MP0008260_abnormal_autophagy1.86148531
37MP0008057_abnormal_DNA_replication1.85661360
38MP0009278_abnormal_bone_marrow1.84665588
39MP0003191_abnormal_cellular_cholesterol1.84063478
40MP0002085_abnormal_embryonic_tissue1.80378470
41MP0002084_abnormal_developmental_patter1.79675058
42MP0005464_abnormal_platelet_physiology1.78184239
43MP0001845_abnormal_inflammatory_respons1.72987279
44MP0010030_abnormal_orbit_morphology1.67288777
45MP0003121_genomic_imprinting1.67253592
46MP0002138_abnormal_hepatobiliary_system1.64722604
47MP0002751_abnormal_autonomic_nervous1.64081216
48* MP0002080_prenatal_lethality1.63788348
49MP0005380_embryogenesis_phenotype1.59968073
50MP0001672_abnormal_embryogenesis/_devel1.59968073
51MP0001697_abnormal_embryo_size1.59220740
52MP0000537_abnormal_urethra_morphology1.58696446
53MP0002396_abnormal_hematopoietic_system1.56823902
54MP0000313_abnormal_cell_death1.55911019
55MP0005310_abnormal_salivary_gland1.54095595
56MP0003828_pulmonary_edema1.53367548
57MP0003890_abnormal_embryonic-extraembry1.53122584
58MP0003861_abnormal_nervous_system1.48888073
59MP0003787_abnormal_imprinting1.48788823
60MP0009764_decreased_sensitivity_to1.48738052
61MP0001853_heart_inflammation1.48369045
62MP0001293_anophthalmia1.47403240
63MP0003183_abnormal_peptide_metabolism1.46295537
64MP0000778_abnormal_nervous_system1.45883523
65MP0002998_abnormal_bone_remodeling1.43222173
66MP0002398_abnormal_bone_marrow1.43140038
67MP0009333_abnormal_splenocyte_physiolog1.42801582
68MP0000703_abnormal_thymus_morphology1.41367764
69MP0005451_abnormal_body_composition1.40691975
70MP0003984_embryonic_growth_retardation1.39516879
71MP0002088_abnormal_embryonic_growth/wei1.38350005
72MP0009379_abnormal_foot_pigmentation1.36858789
73MP0003866_abnormal_defecation1.32628689
74MP0003786_premature_aging1.32376105
75MP0008469_abnormal_protein_level1.31842728
76MP0010352_gastrointestinal_tract_polyps1.31712840
77MP0000689_abnormal_spleen_morphology1.31472061
78MP0004510_myositis1.31384910
79MP0002132_abnormal_respiratory_system1.31364259
80MP0005076_abnormal_cell_differentiation1.30323442
81MP0004197_abnormal_fetal_growth/weight/1.29671533
82MP0000604_amyloidosis1.29270506
83MP0008789_abnormal_olfactory_epithelium1.29143919
84MP0008995_early_reproductive_senescence1.26574658
85MP0003123_paternal_imprinting1.25536887
86MP0002019_abnormal_tumor_incidence1.24326554
87MP0004185_abnormal_adipocyte_glucose1.21979805
88MP0002722_abnormal_immune_system1.21280590
89MP0004130_abnormal_muscle_cell1.19779848
90MP0003221_abnormal_cardiomyocyte_apopto1.18998835
91MP0004381_abnormal_hair_follicle1.17273994
92MP0000716_abnormal_immune_system1.15742273
93MP0001800_abnormal_humoral_immune1.15586642
94MP0003763_abnormal_thymus_physiology1.14591205
95MP0005394_taste/olfaction_phenotype1.14139903
96MP0005499_abnormal_olfactory_system1.14139903
97MP0003075_altered_response_to1.14060660
98MP0002086_abnormal_extraembryonic_tissu1.12738007
99MP0002429_abnormal_blood_cell1.11055283
100MP0000490_abnormal_crypts_of1.09712621
101MP0003690_abnormal_glial_cell1.07936390
102MP0005174_abnormal_tail_pigmentation1.07934279
103MP0000685_abnormal_immune_system1.06788290
104MP0003315_abnormal_perineum_morphology1.02804846
105MP0000465_gastrointestinal_hemorrhage1.00860793
106MP0000343_altered_response_to1.00776432
107MP0002092_abnormal_eye_morphology1.00518262
108MP0001849_ear_inflammation1.00472658
109MP0002420_abnormal_adaptive_immunity0.98411075
110MP0001851_eye_inflammation0.97667417
111MP0001819_abnormal_immune_cell0.96659464
112MP0005390_skeleton_phenotype0.96008122
113MP0005166_decreased_susceptibility_to0.95495099
114MP0002166_altered_tumor_susceptibility0.95351585
115MP0002277_abnormal_respiratory_mucosa0.91966431
116MP0002933_joint_inflammation0.91374140
117MP0009672_abnormal_birth_weight0.90268078
118MP0002452_abnormal_antigen_presenting0.90052322
119MP0002111_abnormal_tail_morphology0.89680069
120MP0003656_abnormal_erythrocyte_physiolo0.89526708
121MP0002152_abnormal_brain_morphology0.89388534
122MP0003938_abnormal_ear_development0.89003827
123MP0003283_abnormal_digestive_organ0.87975308
124MP0000858_altered_metastatic_potential0.87680969
125MP0001873_stomach_inflammation0.87073666
126MP0005379_endocrine/exocrine_gland_phen0.85673023
127MP0010307_abnormal_tumor_latency0.85007913
128MP0002160_abnormal_reproductive_system0.83927792
129MP0000678_abnormal_parathyroid_gland0.83804089
130MP0003115_abnormal_respiratory_system0.82833241
131MP0004883_abnormal_blood_vessel0.81950594
132MP0004808_abnormal_hematopoietic_stem0.81300565
133MP0001663_abnormal_digestive_system0.80911820
134MP0009765_abnormal_xenobiotic_induced0.80821388
135MP0004811_abnormal_neuron_physiology0.80587230
136MP0003303_peritoneal_inflammation0.80286590
137MP0005075_abnormal_melanosome_morpholog0.80048874
138MP0003448_altered_tumor_morphology0.79954407
139MP0001145_abnormal_male_reproductive0.77101000
140MP0001915_intracranial_hemorrhage0.77020783
141MP0009840_abnormal_foam_cell0.76837426
142MP0002081_perinatal_lethality0.76544435
143MP0002723_abnormal_immune_serum0.76532529
144MP0003567_abnormal_fetal_cardiomyocyte0.76526363
145MP0009763_increased_sensitivity_to0.73892330
146MP0002210_abnormal_sex_determination0.73699999
147MP0002075_abnormal_coat/hair_pigmentati0.73201070
148MP0000371_diluted_coat_color0.72730247
149MP0005384_cellular_phenotype0.70682701
150MP0005389_reproductive_system_phenotype0.69988358
151MP0005397_hematopoietic_system_phenotyp0.69738946
152MP0001545_abnormal_hematopoietic_system0.69738946
153MP0000631_abnormal_neuroendocrine_gland0.68738150
154MP0001286_abnormal_eye_development0.68348849
155MP0002139_abnormal_hepatobiliary_system0.67842599
156MP0000428_abnormal_craniofacial_morphol0.67803861
157MP0003795_abnormal_bone_structure0.67587497
158MP0003329_amyloid_beta_deposits0.67092761
159MP0000477_abnormal_intestine_morphology0.66832048
160MP0005164_abnormal_response_to0.66000474
161MP0003453_abnormal_keratinocyte_physiol0.65981009
162MP0005167_abnormal_blood-brain_barrier0.65309947
163MP0005083_abnormal_biliary_tract0.62966154
164MP0000681_abnormal_thyroid_gland0.62648176
165MP0002133_abnormal_respiratory_system0.61607747
166MP0005388_respiratory_system_phenotype0.61607747
167MP0000249_abnormal_blood_vessel0.61000675
168MP0008874_decreased_physiological_sensi0.60888209
169MP0005666_abnormal_adipose_tissue0.56932833
170MP0003091_abnormal_cell_migration0.56905115
171MP0003705_abnormal_hypodermis_morpholog0.56151033
172MP0004858_abnormal_nervous_system0.55685596
173MP0003879_abnormal_hair_cell0.54732511

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.06293124
2Recurrent bacterial skin infections (HP:0005406)5.32985216
3Recurrent abscess formation (HP:0002722)5.32343865
4Abnormality of macrophages (HP:0004311)4.66281224
5Colon cancer (HP:0003003)4.52349655
6Myositis (HP:0100614)4.51741769
7Ependymoma (HP:0002888)4.44796181
8Mediastinal lymphadenopathy (HP:0100721)4.39589299
9Agnosia (HP:0010524)4.27663508
10Orchitis (HP:0100796)4.09893321
11Amyotrophic lateral sclerosis (HP:0007354)4.04844707
12Recurrent gram-negative bacterial infections (HP:0005420)4.03333952
13Medulloblastoma (HP:0002885)3.83783655
14Optic neuritis (HP:0100653)3.82329918
15Retrobulbar optic neuritis (HP:0100654)3.82329918
16Recurrent fungal infections (HP:0002841)3.70335762
17Spontaneous hematomas (HP:0007420)3.56762183
18Meningitis (HP:0001287)3.53248854
19Elevated erythrocyte sedimentation rate (HP:0003565)3.44243127
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.42408674
21Cerebral hypomyelination (HP:0006808)3.38674974
22Atrophy/Degeneration involving motor neurons (HP:0007373)3.38062580
23Reticulocytopenia (HP:0001896)3.37155319
24Abnormality of liposaccharide metabolism (HP:0010968)3.35182781
25Abnormality of glycosphingolipid metabolism (HP:0004343)3.35182781
26Abnormality of glycolipid metabolism (HP:0010969)3.35182781
27Recurrent skin infections (HP:0001581)3.33463399
28Patellar aplasia (HP:0006443)3.32703409
29Gingivitis (HP:0000230)3.30603359
30Stomatitis (HP:0010280)3.30477325
31Obstructive lung disease (HP:0006536)3.25919753
32Chronic obstructive pulmonary disease (HP:0006510)3.25919753
33Gastrointestinal infarctions (HP:0005244)3.16685736
34Astrocytoma (HP:0009592)3.16043814
35Abnormality of the astrocytes (HP:0100707)3.16043814
36Increased IgE level (HP:0003212)3.06571766
37Vasculitis (HP:0002633)3.01850743
38Aplasia/Hypoplasia of the patella (HP:0006498)3.00382714
39Recurrent viral infections (HP:0004429)2.98071037
40Pulmonary infiltrates (HP:0002113)2.90704517
41Encephalitis (HP:0002383)2.88506846
42Hyperacusis (HP:0010780)2.88276293
43Absent thumb (HP:0009777)2.86945645
44Chronic mucocutaneous candidiasis (HP:0002728)2.84309380
45Recurrent cutaneous fungal infections (HP:0011370)2.84309380
46Urticaria (HP:0001025)2.82641475
47Broad alveolar ridges (HP:0000187)2.81029045
48Panhypogammaglobulinemia (HP:0003139)2.80450008
49Keratoconjunctivitis sicca (HP:0001097)2.78462166
50Multiple enchondromatosis (HP:0005701)2.75683882
51Dysostosis multiplex (HP:0000943)2.71827921
52Colitis (HP:0002583)2.71783536
53Increased cerebral lipofuscin (HP:0011813)2.70561941
54Basal cell carcinoma (HP:0002671)2.70360521
55Abnormality of cells of the erythroid lineage (HP:0012130)2.69953178
56Aplasia/Hypoplasia of the sternum (HP:0006714)2.68156551
57Neoplasm of the oral cavity (HP:0100649)2.67026923
58Hemoptysis (HP:0002105)2.64181216
59Papilloma (HP:0012740)2.63310545
60Verrucae (HP:0200043)2.63310545
61Chest pain (HP:0100749)2.59240593
62Spinal muscular atrophy (HP:0007269)2.58321750
63Abnormality of the anterior horn cell (HP:0006802)2.57291137
64Degeneration of anterior horn cells (HP:0002398)2.57291137
65Systemic lupus erythematosus (HP:0002725)2.53849297
66Gastrointestinal inflammation (HP:0004386)2.52522601
67Granulocytopenia (HP:0001913)2.51283642
68Leukocytosis (HP:0001974)2.50336223
69Hypochromic anemia (HP:0001931)2.49109502
70Keratoconjunctivitis (HP:0001096)2.48718794
71Inflammation of the large intestine (HP:0002037)2.47324664
72Disinhibition (HP:0000734)2.44274811
73Increased nuchal translucency (HP:0010880)2.43081359
74Renal duplication (HP:0000075)2.42556362
75Abnormality of the intervertebral disk (HP:0005108)2.41888869
76Autoimmune thrombocytopenia (HP:0001973)2.41694787
77Agammaglobulinemia (HP:0004432)2.41440683
78Abnormality of T cell number (HP:0011839)2.38156634
79Gastrointestinal stroma tumor (HP:0100723)2.38023615
80T lymphocytopenia (HP:0005403)2.37949163
81Abnormal neuron morphology (HP:0012757)2.36930627
82Abnormality of the motor neurons (HP:0002450)2.36930627
83Osteomyelitis (HP:0002754)2.35872102
84Pustule (HP:0200039)2.34313507
85Prolonged bleeding time (HP:0003010)2.33440073
86Visual hallucinations (HP:0002367)2.32188979
87Increased IgM level (HP:0003496)2.31576783
88Overriding aorta (HP:0002623)2.31079902
89Neoplasm of the pancreas (HP:0002894)2.30653690
90Glioma (HP:0009733)2.29504743
91Polygenic inheritance (HP:0010982)2.26865785
92Abnormal number of erythroid precursors (HP:0012131)2.26317164
93Adenoma sebaceum (HP:0009720)2.25468306
94Angiofibromas (HP:0010615)2.25468306
95Arterial thrombosis (HP:0004420)2.23627198
96Restrictive lung disease (HP:0002091)2.23471615
97Glossoptosis (HP:0000162)2.22647179
98Abnormality of the labia minora (HP:0012880)2.22503799
99Amyloidosis (HP:0011034)2.21679115
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19144196
101Hematochezia (HP:0002573)2.18787971
102Lymphopenia (HP:0001888)2.17386997
103Increased neuronal autofluorescent lipopigment (HP:0002074)2.17300475
104Pulmonary embolism (HP:0002204)2.16081491
105Eosinophilia (HP:0001880)2.15577834
106Insomnia (HP:0100785)2.15524939
107Loss of speech (HP:0002371)2.15394160
108Abnormality of the salivary glands (HP:0010286)2.14942438
109Selective tooth agenesis (HP:0001592)2.13717000
110Abnormality of cells of the lymphoid lineage (HP:0012140)2.13538066
111Sepsis (HP:0100806)2.13032867
112Cellulitis (HP:0100658)2.11953879
113Trismus (HP:0000211)2.11573137
114CNS hypomyelination (HP:0003429)2.11305122
115Macrocytic anemia (HP:0001972)2.11036770
116Purpura (HP:0000979)2.10613731
117Breast hypoplasia (HP:0003187)2.10328611
118Elfin facies (HP:0004428)2.09986449
119Abnormality of the lower motor neuron (HP:0002366)2.08795934
120Rhabdomyosarcoma (HP:0002859)2.06497715
121Amaurosis fugax (HP:0100576)2.06370003
122Orthostatic hypotension (HP:0001278)2.05952184
123Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05620712
124Abnormality of polysaccharide metabolism (HP:0011012)2.05620712
125Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05620712
126Slow saccadic eye movements (HP:0000514)2.05475798
127Epistaxis (HP:0000421)2.05463258
128Abnormality of T cells (HP:0002843)2.04486196
129Asplenia (HP:0001746)2.04406248
130Spina bifida occulta (HP:0003298)2.04101325
131Interstitial pulmonary disease (HP:0006530)2.03819447
132Cutaneous melanoma (HP:0012056)2.03627597
133Increased serum ferritin (HP:0003281)2.02860438
134Mucopolysacchariduria (HP:0008155)2.02630955
135Urinary glycosaminoglycan excretion (HP:0003541)2.02630955
136Horseshoe kidney (HP:0000085)2.00976824
137Porencephaly (HP:0002132)2.00972352
138Abnormality of the pleura (HP:0002103)1.99394672
139Birth length less than 3rd percentile (HP:0003561)1.98042878
140Pathologic fracture (HP:0002756)1.96701912
141Malignant gastrointestinal tract tumors (HP:0006749)1.96688713
142Gastrointestinal carcinoma (HP:0002672)1.96688713
143Hypergammaglobulinemia (HP:0010702)1.96239520
144Facial hemangioma (HP:0000329)1.96037533
145Anorexia (HP:0002039)1.95509010
146Aplasia/Hypoplasia of the spleen (HP:0010451)1.93933034
147Hemiplegia (HP:0002301)1.93755436
148Viral hepatitis (HP:0006562)1.93110155
149Tracheoesophageal fistula (HP:0002575)1.92668322
150Sex reversal (HP:0012245)1.92512729
151Abnormal sex determination (HP:0012244)1.92512729
152Petechiae (HP:0000967)1.92301443
153Poikiloderma (HP:0001029)1.91428869
154Emphysema (HP:0002097)1.90787518
155Acute lymphatic leukemia (HP:0006721)1.90750974
156Ankle contracture (HP:0006466)1.89936662
157Hypermelanotic macule (HP:0001034)1.89889523
158Abnormal lung lobation (HP:0002101)1.89457176
159Cutis marmorata (HP:0000965)1.89187003
160Gingival bleeding (HP:0000225)1.88930177
161Renovascular hypertension (HP:0100817)1.88750576
162Episodic fever (HP:0001954)1.88323315
163Recurrent pneumonia (HP:0006532)1.88095280
164Impulsivity (HP:0100710)1.87705458
165Malnutrition (HP:0004395)1.87561808
166Freckling (HP:0001480)1.87160716
167Abnormality of hair growth rate (HP:0011363)1.86765709
168Slow-growing hair (HP:0002217)1.86765709
169Pallor (HP:0000980)1.86268793
170Hypochromic microcytic anemia (HP:0004840)1.85820451
171Autoimmune hemolytic anemia (HP:0001890)1.85375147
172Diminished motivation (HP:0000745)1.84223475
173Personality changes (HP:0000751)1.82777239
174Missing ribs (HP:0000921)1.80585882
175Wrist flexion contracture (HP:0001239)1.79170926
176High anterior hairline (HP:0009890)1.75640355
177Premature graying of hair (HP:0002216)1.73845214
178Tongue fasciculations (HP:0001308)1.73792805
179Neoplasm of striated muscle (HP:0009728)1.71887232
180Deep palmar crease (HP:0006191)1.69653232
181Chronic otitis media (HP:0000389)1.69411018
182Supernumerary spleens (HP:0009799)1.69249533
183Optic nerve coloboma (HP:0000588)1.68510215
184Absent radius (HP:0003974)1.68181402
185Apathy (HP:0000741)1.68053297
186Myelodysplasia (HP:0002863)1.66038603
187Short 4th metacarpal (HP:0010044)1.65213636
188Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.65213636
189Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.64876899
190Proximal placement of thumb (HP:0009623)1.64693879
191Peripheral hypomyelination (HP:0007182)1.64678375
192Abnormality of the diencephalon (HP:0010662)1.63034599
193Shoulder girdle muscle weakness (HP:0003547)1.62547560
194Progressive muscle weakness (HP:0003323)1.61726611
195Recurrent bronchitis (HP:0002837)1.61674571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.07336535
2RIPK43.95193191
3MAP3K103.59955526
4EEF2K3.37870759
5TESK23.20940468
6ERN13.06239718
7TSSK62.81068933
8ICK2.73901704
9MAP2K32.66340553
10IRAK42.48590866
11TYK22.33027060
12PKN22.28919648
13MARK12.28834854
14GRK62.14565298
15DYRK22.11987530
16DYRK31.96892740
17BLK1.95284638
18SRPK11.91755175
19MAP4K11.91350592
20CDC71.89795666
21PRKD21.89115898
22ZAP701.87246890
23PASK1.86677596
24SMG11.83568310
25MAP3K141.82389222
26CDK191.77750224
27WEE11.68604511
28PAK41.66374708
29TBK11.64495389
30PRPF4B1.62673842
31EPHB11.60784183
32LRRK21.59717097
33MAP3K111.58496266
34EPHA21.58482528
35NEK21.57640742
36UHMK11.55245835
37CDK71.54488611
38RPS6KB21.51191659
39CDK121.49995975
40CSF1R1.48773581
41JAK31.48095140
42TNK21.44841316
43IKBKE1.44129337
44TRIB31.43988731
45MAP3K131.43785951
46TAOK11.42637304
47MAP3K31.40453240
48STK101.37611602
49MKNK11.31044931
50TXK1.29508651
51TLK11.27791821
52STK241.26623955
53LYN1.25519986
54MARK21.24731248
55DYRK1B1.21087629
56SIK11.17209872
57ALK1.17163546
58MAP3K81.15220061
59NEK11.15066251
60SIK31.13539768
61JAK11.13101202
62MAP3K11.12137842
63PLK11.11073885
64IKBKB1.11016577
65TGFBR11.08373993
66JAK21.04100450
67LCK1.01708298
68TAOK21.00978855
69TAOK31.00646998
70SCYL21.00134116
71RIPK10.98944915
72MATK0.98082741
73FGFR40.97771769
74ATR0.97729858
75SIK20.96083650
76MAP3K60.94859806
77LIMK10.94519514
78CDK40.94096081
79VRK10.93181007
80IRAK30.91097712
81YES10.89387807
82RPS6KA40.88964041
83FLT30.88843790
84TYRO30.87943306
85EIF2AK10.84129017
86IRAK20.84072555
87AURKA0.82176269
88PLK30.82017670
89ITK0.81963509
90PAK10.81533503
91EPHA30.81190112
92PDPK10.81063025
93CHEK10.78821422
94IRAK10.78483081
95CDC42BPA0.78389366
96CDK20.76493180
97HIPK20.75936512
98RPS6KL10.75894485
99MARK30.75448982
100MAPK120.75124971
101PDK10.74166189
102DAPK10.73645961
103CAMKK10.73590072
104KSR20.72870167
105NME20.69501306
106TTK0.68686468
107BTK0.66607908
108MAP2K40.65807459
109PRKCI0.64844150
110FGFR30.64261207
111AURKB0.63855816
112STK40.63636521
113GRK70.63196809
114TEC0.62631893
115RPS6KA60.61650388
116MAP3K70.61552292
117CLK10.61339940
118FGR0.61312232
119CSNK1G30.61103446
120BRSK10.60981012
121FYN0.59566499
122ILK0.58628198
123BCKDK0.57617769
124MAPK70.57036162
125SGK30.56982805
126BMPR20.56726064
127RPS6KA20.55777886
128MAP2K20.55152412
129RPS6KA10.54801566
130KIT0.54544815
131RPS6KA50.53983380
132PIM10.53859582
133SYK0.53417321
134RET0.52316913
135CSNK2A20.51447394
136BMX0.51136323
137CAMKK20.51048052
138CDK10.50019579
139MTOR0.49577299
140PTK60.48629176
141DAPK30.47412666
142TGFBR20.45283396
143STK110.45222260
144MAPK90.43157275
145FES0.42879005
146PNCK0.42460615
147STK160.41742398
148MAPK40.40951073
149ROCK20.40725680
150CHEK20.39109569
151CSNK1E0.38349453
152PRKD10.38149304
153MAPKAPK20.37125356
154CDK11A0.36841756
155PRKCH0.36116180
156TESK10.35566678
157MAPKAPK30.34898123
158MAP2K60.33946024
159NEK90.33855187
160DAPK20.33736540
161KSR10.33653150
162EIF2AK30.33162539
163CSK0.33147707
164MAPK110.33063621
165HCK0.33048744
166BRD40.31935135
167MAPK130.31126350
168RPS6KC10.31085789

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030404.06934054
2Mismatch repair_Homo sapiens_hsa034303.79669087
3Ribosome_Homo sapiens_hsa030103.56676079
4DNA replication_Homo sapiens_hsa030303.50791645
5RNA polymerase_Homo sapiens_hsa030203.41891321
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.92277759
7Base excision repair_Homo sapiens_hsa034102.85850806
8RNA transport_Homo sapiens_hsa030132.78673126
9Proteasome_Homo sapiens_hsa030502.76552722
10Osteoclast differentiation_Homo sapiens_hsa043802.73749530
11Leishmaniasis_Homo sapiens_hsa051402.64762674
12Staphylococcus aureus infection_Homo sapiens_hsa051502.57201422
13Allograft rejection_Homo sapiens_hsa053302.32688626
14Nucleotide excision repair_Homo sapiens_hsa034202.20819362
15Graft-versus-host disease_Homo sapiens_hsa053322.20486784
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19102805
17Autoimmune thyroid disease_Homo sapiens_hsa053202.18215258
18Pyrimidine metabolism_Homo sapiens_hsa002402.16907086
19mRNA surveillance pathway_Homo sapiens_hsa030151.94057170
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.93125170
21Tuberculosis_Homo sapiens_hsa051521.92602992
22Homologous recombination_Homo sapiens_hsa034401.91339645
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.85757653
24Cell cycle_Homo sapiens_hsa041101.84188851
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.76171564
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75151191
27Asthma_Homo sapiens_hsa053101.75083430
28Epstein-Barr virus infection_Homo sapiens_hsa051691.70622756
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67575469
30Notch signaling pathway_Homo sapiens_hsa043301.66913935
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59719028
32B cell receptor signaling pathway_Homo sapiens_hsa046621.59376842
33Type I diabetes mellitus_Homo sapiens_hsa049401.55438878
34Colorectal cancer_Homo sapiens_hsa052101.51022401
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.48539140
36Non-homologous end-joining_Homo sapiens_hsa034501.47614051
37Malaria_Homo sapiens_hsa051441.42389167
38Hematopoietic cell lineage_Homo sapiens_hsa046401.40722825
39One carbon pool by folate_Homo sapiens_hsa006701.40231221
40Fanconi anemia pathway_Homo sapiens_hsa034601.37084094
41Primary immunodeficiency_Homo sapiens_hsa053401.34026625
42TNF signaling pathway_Homo sapiens_hsa046681.33281339
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30008054
44Antigen processing and presentation_Homo sapiens_hsa046121.25474157
45Viral carcinogenesis_Homo sapiens_hsa052031.25158018
46Systemic lupus erythematosus_Homo sapiens_hsa053221.23200691
47RNA degradation_Homo sapiens_hsa030181.21545197
48Phagosome_Homo sapiens_hsa041451.19241053
49Basal transcription factors_Homo sapiens_hsa030221.17948861
50Endometrial cancer_Homo sapiens_hsa052131.17203983
51Basal cell carcinoma_Homo sapiens_hsa052171.14675367
52Lysosome_Homo sapiens_hsa041421.13983424
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.13016589
54Hepatitis C_Homo sapiens_hsa051601.11853485
55Rheumatoid arthritis_Homo sapiens_hsa053231.11495604
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09417381
57Acute myeloid leukemia_Homo sapiens_hsa052211.01894524
58Non-small cell lung cancer_Homo sapiens_hsa052230.99645989
59Herpes simplex infection_Homo sapiens_hsa051680.99473882
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.98100441
61p53 signaling pathway_Homo sapiens_hsa041150.97712372
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95391462
63Chronic myeloid leukemia_Homo sapiens_hsa052200.93178636
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92168812
65Shigellosis_Homo sapiens_hsa051310.91088240
66African trypanosomiasis_Homo sapiens_hsa051430.91063342
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88716526
68HTLV-I infection_Homo sapiens_hsa051660.86727839
69Apoptosis_Homo sapiens_hsa042100.85880808
70Platelet activation_Homo sapiens_hsa046110.85444058
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.85422535
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84619509
73Alcoholism_Homo sapiens_hsa050340.83364489
74Purine metabolism_Homo sapiens_hsa002300.82323697
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82261015
76MicroRNAs in cancer_Homo sapiens_hsa052060.81562459
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.81162653
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79555675
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79325223
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78902616
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78738390
82Salmonella infection_Homo sapiens_hsa051320.78146240
83Oocyte meiosis_Homo sapiens_hsa041140.77990787
84Hedgehog signaling pathway_Homo sapiens_hsa043400.75878543
85Hippo signaling pathway_Homo sapiens_hsa043900.72415594
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.71973824
87Thyroid cancer_Homo sapiens_hsa052160.70311875
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.70198410
89Biosynthesis of amino acids_Homo sapiens_hsa012300.69867334
90Renal cell carcinoma_Homo sapiens_hsa052110.68618236
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67603338
92T cell receptor signaling pathway_Homo sapiens_hsa046600.67401384
93Choline metabolism in cancer_Homo sapiens_hsa052310.67326529
94GnRH signaling pathway_Homo sapiens_hsa049120.67195682
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65025474
96Type II diabetes mellitus_Homo sapiens_hsa049300.64630201
97MAPK signaling pathway_Homo sapiens_hsa040100.63455116
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62977938
99Pathways in cancer_Homo sapiens_hsa052000.62719790
100Pentose phosphate pathway_Homo sapiens_hsa000300.61929698
101mTOR signaling pathway_Homo sapiens_hsa041500.60785162
102Viral myocarditis_Homo sapiens_hsa054160.59486901
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59032032
104Sulfur relay system_Homo sapiens_hsa041220.58573477
105VEGF signaling pathway_Homo sapiens_hsa043700.55827766
106Small cell lung cancer_Homo sapiens_hsa052220.54766415
107Axon guidance_Homo sapiens_hsa043600.54763445
108Insulin resistance_Homo sapiens_hsa049310.52313192
109Folate biosynthesis_Homo sapiens_hsa007900.51624824
110Legionellosis_Homo sapiens_hsa051340.51187909
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50991747
112Influenza A_Homo sapiens_hsa051640.50974022
113Hepatitis B_Homo sapiens_hsa051610.50553946
114Rap1 signaling pathway_Homo sapiens_hsa040150.50002822
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.49673021
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49176267
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49031340
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.48468325
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48259171
120Measles_Homo sapiens_hsa051620.48167793
121Galactose metabolism_Homo sapiens_hsa000520.47654989
122Amoebiasis_Homo sapiens_hsa051460.46805017
123Wnt signaling pathway_Homo sapiens_hsa043100.45222792
124Dorso-ventral axis formation_Homo sapiens_hsa043200.44828633
125Endocytosis_Homo sapiens_hsa041440.43246606
126Estrogen signaling pathway_Homo sapiens_hsa049150.43197922
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40579216
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40120029
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39971391
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39711177
131Pancreatic cancer_Homo sapiens_hsa052120.39652272
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39152298
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.38776089
134Other glycan degradation_Homo sapiens_hsa005110.37228995
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36364785
136Prion diseases_Homo sapiens_hsa050200.36119012
137Renin-angiotensin system_Homo sapiens_hsa046140.35605918
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35089208
139FoxO signaling pathway_Homo sapiens_hsa040680.34708464
140Glioma_Homo sapiens_hsa052140.31737159
141N-Glycan biosynthesis_Homo sapiens_hsa005100.31539659
142Prolactin signaling pathway_Homo sapiens_hsa049170.31137044
143HIF-1 signaling pathway_Homo sapiens_hsa040660.29021664
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27558063
145Toxoplasmosis_Homo sapiens_hsa051450.27273121
146Cyanoamino acid metabolism_Homo sapiens_hsa004600.27205307
147Chemokine signaling pathway_Homo sapiens_hsa040620.26294521
148ErbB signaling pathway_Homo sapiens_hsa040120.26098667
149Bladder cancer_Homo sapiens_hsa052190.24966404
150Prostate cancer_Homo sapiens_hsa052150.24963575
151Pertussis_Homo sapiens_hsa051330.24630492

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