ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	muscle cell fate commitment (GO:0042693)	9.92364613
2	tongue development (GO:0043586)	5.66247259
3	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	5.50804643
4	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	5.50804643
5	cell aggregation (GO:0098743)	5.31358320
6	cartilage condensation (GO:0001502)	5.31358320
7	protein complex biogenesis (GO:0070271)	5.03651140
8	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.57753992
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.57753992
10	NADH dehydrogenase complex assembly (GO:0010257)	4.57753992
11	muscle cell cellular homeostasis (GO:0046716)	4.57064282
12	regulation of cilium movement (GO:0003352)	4.53202850
13	mitochondrial respiratory chain complex assembly (GO:0033108)	4.32309970
14	N-acetylglucosamine metabolic process (GO:0006044)	4.23869675
15	protein heterotetramerization (GO:0051290)	4.21820258
16	sodium-independent organic anion transport (GO:0043252)	4.07662706
17	regulation of sarcomere organization (GO:0060297)	4.00228763
18	lymphangiogenesis (GO:0001946)	3.98194655
19	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.92488714
20	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.91718411
21	positive regulation of vesicle fusion (GO:0031340)	3.88061422
22	negative regulation of mast cell activation (GO:0033004)	3.80822588
23	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.79697111
24	transepithelial transport (GO:0070633)	3.78133099
25	regulation of MHC class I biosynthetic process (GO:0045343)	3.74168325
26	DNA double-strand break processing (GO:0000729)	3.72518194
27	signal peptide processing (GO:0006465)	3.71633286
28	cellular potassium ion homeostasis (GO:0030007)	3.70212949
29	somitogenesis (GO:0001756)	3.69062561
30	oligodendrocyte differentiation (GO:0048709)	3.68470197
31	N-acetylneuraminate metabolic process (GO:0006054)	3.68465093
32	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.68048706
33	negative regulation of JUN kinase activity (GO:0043508)	3.59123670
34	negative regulation of nitric-oxide synthase activity (GO:0051001)	3.56892979
35	musculoskeletal movement (GO:0050881)	3.56268299
36	multicellular organismal movement (GO:0050879)	3.56268299
37	membrane budding (GO:0006900)	3.55103121
38	membrane raft organization (GO:0031579)	3.51391809
39	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.49022874
40	replication fork processing (GO:0031297)	3.46310926
41	regulation of translation in response to stress (GO:0043555)	3.46169371
42	positive regulation of protein autophosphorylation (GO:0031954)	3.38392498
43	segmentation (GO:0035282)	3.33608438
44	lung lobe morphogenesis (GO:0060463)	3.33098113
45	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.31185373
46	positive regulation of muscle hypertrophy (GO:0014742)	3.27132739
47	positive regulation of cardiac muscle hypertrophy (GO:0010613)	3.27132739
48	glucosamine-containing compound metabolic process (GO:1901071)	3.25277934
49	membrane assembly (GO:0071709)	3.23862332
50	skeletal muscle tissue development (GO:0007519)	3.23289289
51	rRNA catabolic process (GO:0016075)	3.19646472
52	recombinational repair (GO:0000725)	3.19298758
53	auditory receptor cell stereocilium organization (GO:0060088)	3.19103364
54	double-strand break repair via homologous recombination (GO:0000724)	3.13766182
55	histone H2A acetylation (GO:0043968)	3.09288731
56	defense response to Gram-negative bacterium (GO:0050829)	3.03905174
57	rRNA modification (GO:0000154)	3.00765455
58	natural killer cell activation involved in immune response (GO:0002323)	2.97401832
59	potassium ion import (GO:0010107)	2.96876957
60	activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)	2.95827665
61	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.95205464
62	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.93619618
63	endocardial cushion morphogenesis (GO:0003203)	2.92182165
64	nephron tubule formation (GO:0072079)	2.88814846
65	positive regulation of interleukin-8 secretion (GO:2000484)	2.88038962
66	positive regulation of T cell chemotaxis (GO:0010820)	2.87066978
67	regulation of T cell chemotaxis (GO:0010819)	2.87066978
68	mannosylation (GO:0097502)	2.86512177
69	positive regulation of actin filament depolymerization (GO:0030836)	2.84085603
70	ncRNA catabolic process (GO:0034661)	2.81743271
71	regulation of metalloenzyme activity (GO:0048552)	2.78930389
72	dopamine transport (GO:0015872)	2.78243261
73	lactate metabolic process (GO:0006089)	2.77416195
74	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.74047716
75	limb bud formation (GO:0060174)	2.72892401
76	forebrain neuron development (GO:0021884)	2.71701638
77	anterograde synaptic vesicle transport (GO:0048490)	2.70706601
78	DNA demethylation (GO:0080111)	2.70228486
79	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.70074108
80	cellular response to ethanol (GO:0071361)	2.69098312
81	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.68078349
82	interleukin-6-mediated signaling pathway (GO:0070102)	2.67995601
83	regulation of protein glycosylation (GO:0060049)	2.67766076
84	regulation of interleukin-8 secretion (GO:2000482)	2.67652923
85	positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081	2.67518328
86	regulation of respiratory burst (GO:0060263)	2.66305339
87	negative regulation of execution phase of apoptosis (GO:1900118)	2.64138802
88	negative regulation of macroautophagy (GO:0016242)	2.60838153
89	positive regulation of cell size (GO:0045793)	2.60186640
90	regulation of alkaline phosphatase activity (GO:0010692)	2.58988457
91	glycosphingolipid biosynthetic process (GO:0006688)	2.58964668
92	proline transport (GO:0015824)	2.57427515
93	cytochrome complex assembly (GO:0017004)	2.57070821
94	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.56716720
95	fucose catabolic process (GO:0019317)	2.56635068
96	L-fucose metabolic process (GO:0042354)	2.56635068
97	L-fucose catabolic process (GO:0042355)	2.56635068
98	activation of protein kinase B activity (GO:0032148)	2.56548579
99	neuromuscular synaptic transmission (GO:0007274)	2.55976641
100	sodium ion export (GO:0071436)	2.55952995

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.44002008
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	4.65018595
3	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.04478294
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.02471899
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.84255342
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.79409320
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.63042272
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.38793619
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.38771053
10	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.28584499
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.12373563
12	BCAT_22108803_ChIP-Seq_LS180_Human	2.10066903
13	VDR_22108803_ChIP-Seq_LS180_Human	2.07348272
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.06220043
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.01627527
16	P300_19829295_ChIP-Seq_ESCs_Human	1.99815298
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.93354808
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.92099464
19	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.90370911
20	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.80265256
21	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.78975001
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.73920320
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.71992507
24	FUS_26573619_Chip-Seq_HEK293_Human	1.71923653
25	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.68187368
26	EWS_26573619_Chip-Seq_HEK293_Human	1.63279412
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58803870
28	AR_25329375_ChIP-Seq_VCAP_Human	1.57475038
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57224502
30	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.57085746
31	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.56621615
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.54638742
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.53485110
34	TAF15_26573619_Chip-Seq_HEK293_Human	1.51951927
35	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.50748984
36	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.50741977
37	CJUN_26792858_Chip-Seq_BT549_Human	1.49023481
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.45265056
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.45265056
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.44705853
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.43501281
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.42083759
43	CDX2_22108803_ChIP-Seq_LS180_Human	1.39392178
44	BRD4_25478319_ChIP-Seq_HGPS_Human	1.36625813
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.35627616
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35135150
47	TCF4_23295773_ChIP-Seq_U87_Human	1.34175200
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33509276
49	STAT3_23295773_ChIP-Seq_U87_Human	1.33359889
50	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.32051010
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30424290
52	TCF4_22108803_ChIP-Seq_LS180_Human	1.30215744
53	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.30030044
54	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.29602333
55	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.29058837
56	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.27987563
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.27753233
58	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.27057131
59	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27057131
60	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.26383554
61	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.26035794
62	RXR_22108803_ChIP-Seq_LS180_Human	1.25405639
63	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.24979007
64	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.24010337
65	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.23588531
66	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.22585334
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20042961
68	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.18980550
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.18620437
70	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.18270994
71	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17950427
72	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.15074025
73	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.15074025
74	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.12477184
75	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.12431608
76	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.12374540
77	RUNX2_22187159_ChIP-Seq_PCA_Human	1.11944130
78	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10917826
79	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10275443
80	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10275443
81	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.08861459
82	P53_22387025_ChIP-Seq_ESCs_Mouse	1.07478461
83	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.07010232
84	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.06889513
85	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.06791091
86	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05627818
87	TP53_22573176_ChIP-Seq_HFKS_Human	1.05062053
88	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.04564814
89	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.04363717
90	TP53_18474530_ChIP-ChIP_U2OS_Human	1.04281262
91	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04280587
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.03364627
93	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.03175585
94	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.03092139
95	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.03082450
96	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.02882092
97	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.01239951
98	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00543944
99	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99787828
100	AR_20517297_ChIP-Seq_VCAP_Human	0.99413701

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002234_abnormal_pharynx_morphology	8.11261188
2	MP0003300_gastrointestinal_ulcer	4.93282992
3	MP0003950_abnormal_plasma_membrane	4.32341930
4	MP0003191_abnormal_cellular_cholesterol	3.51356498
5	MP0006054_spinal_hemorrhage	3.38053310
6	MP0000569_abnormal_digit_pigmentation	3.37354132
7	MP0000750_abnormal_muscle_regeneration	3.09855434
8	MP0009780_abnormal_chondrocyte_physiolo	2.85142314
9	MP0001853_heart_inflammation	2.24383609
10	MP0005360_urolithiasis	2.13133656
11	MP0005379_endocrine/exocrine_gland_phen	1.98291066
12	MP0002108_abnormal_muscle_morphology	1.97178721
13	MP0000013_abnormal_adipose_tissue	1.95425291
14	MP0010368_abnormal_lymphatic_system	1.85067663
15	MP0004885_abnormal_endolymph	1.84618565
16	MP0005423_abnormal_somatic_nervous	1.82194209
17	MP0008875_abnormal_xenobiotic_pharmacok	1.81881707
18	MP0006072_abnormal_retinal_apoptosis	1.80256443
19	MP0005310_abnormal_salivary_gland	1.78225492
20	MP0000733_abnormal_muscle_development	1.76901469
21	MP0005670_abnormal_white_adipose	1.73039633
22	MP0003787_abnormal_imprinting	1.70815933
23	MP0001984_abnormal_olfaction	1.64069341
24	MP0002282_abnormal_trachea_morphology	1.62266855
25	MP0003868_abnormal_feces_composition	1.59804912
26	MP0005645_abnormal_hypothalamus_physiol	1.59439941
27	MP0001529_abnormal_vocalization	1.55125830
28	MP0009764_decreased_sensitivity_to	1.51757444
29	MP0004883_abnormal_blood_vessel	1.51684048
30	MP0002163_abnormal_gland_morphology	1.48079204
31	MP0003866_abnormal_defecation	1.44552300
32	MP0003137_abnormal_impulse_conducting	1.44247941
33	MP0000538_abnormal_urinary_bladder	1.40299817
34	MP0003011_delayed_dark_adaptation	1.37707259
35	MP0002736_abnormal_nociception_after	1.37501192
36	MP0000372_irregular_coat_pigmentation	1.36174426
37	MP0005253_abnormal_eye_physiology	1.34411590
38	MP0002272_abnormal_nervous_system	1.25775723
39	MP0001485_abnormal_pinna_reflex	1.22801761
40	MP0002138_abnormal_hepatobiliary_system	1.22118570
41	MP0010386_abnormal_urinary_bladder	1.12624156
42	MP0000516_abnormal_urinary_system	1.12543201
43	MP0005367_renal/urinary_system_phenotyp	1.12543201
44	MP0002837_dystrophic_cardiac_calcinosis	1.11433180
45	MP0002932_abnormal_joint_morphology	1.09269423
46	MP0009765_abnormal_xenobiotic_induced	1.08505996
47	MP0002734_abnormal_mechanical_nocicepti	1.08453160
48	MP0003959_abnormal_lean_body	1.08206411
49	MP0008872_abnormal_physiological_respon	1.07283384
50	MP0009745_abnormal_behavioral_response	1.02865385
51	MP0003279_aneurysm	1.01490852
52	MP0004270_analgesia	1.00639606
53	MP0005084_abnormal_gallbladder_morpholo	0.98878671
54	MP0004142_abnormal_muscle_tone	0.98524744
55	MP0000465_gastrointestinal_hemorrhage	0.95889326
56	MP0003646_muscle_fatigue	0.95417385
57	MP0001486_abnormal_startle_reflex	0.93663350
58	MP0008058_abnormal_DNA_repair	0.91093841
59	MP0003633_abnormal_nervous_system	0.90194120
60	MP0003045_fibrosis	0.85506155
61	MP0001968_abnormal_touch/_nociception	0.84581975
62	MP0005166_decreased_susceptibility_to	0.82902598
63	MP0005623_abnormal_meninges_morphology	0.81712774
64	MP0005220_abnormal_exocrine_pancreas	0.80652860
65	MP0002332_abnormal_exercise_endurance	0.78783476
66	MP0000015_abnormal_ear_pigmentation	0.77473114
67	MP0005174_abnormal_tail_pigmentation	0.73876665
68	MP0008775_abnormal_heart_ventricle	0.72941909
69	MP0001879_abnormal_lymphatic_vessel	0.71157236
70	MP0002139_abnormal_hepatobiliary_system	0.70926929
71	MP0003755_abnormal_palate_morphology	0.69407078
72	MP0003186_abnormal_redox_activity	0.68251887
73	MP0005164_abnormal_response_to	0.66743968
74	MP0001873_stomach_inflammation	0.65875945
75	MP0010234_abnormal_vibrissa_follicle	0.65789534
76	MP0005595_abnormal_vascular_smooth	0.64618750
77	MP0005389_reproductive_system_phenotype	0.64530800
78	MP0005023_abnormal_wound_healing	0.63852034
79	MP0002102_abnormal_ear_morphology	0.63508533
80	MP0000358_abnormal_cell_content/	0.62973587
81	MP0002733_abnormal_thermal_nociception	0.62362177
82	MP0010094_abnormal_chromosome_stability	0.62137848
83	MP0002160_abnormal_reproductive_system	0.61859608
84	MP0005452_abnormal_adipose_tissue	0.60323643
85	MP0002168_other_aberrant_phenotype	0.60017684
86	MP0000343_altered_response_to	0.59341400
87	MP0003121_genomic_imprinting	0.59182434
88	MP0001915_intracranial_hemorrhage	0.58701245
89	MP0002106_abnormal_muscle_physiology	0.58222945
90	MP0005332_abnormal_amino_acid	0.55730794
91	MP0001970_abnormal_pain_threshold	0.54812649
92	MP0008438_abnormal_cutaneous_collagen	0.54574921
93	MP0000762_abnormal_tongue_morphology	0.54484203
94	MP0001764_abnormal_homeostasis	0.54130619
95	MP0004215_abnormal_myocardial_fiber	0.54024923
96	MP0003252_abnormal_bile_duct	0.52570668
97	MP0005646_abnormal_pituitary_gland	0.52354341
98	MP0001542_abnormal_bone_strength	0.52288682
99	MP0002972_abnormal_cardiac_muscle	0.52036715
100	MP0000759_abnormal_skeletal_muscle	0.51642243

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Amniotic constriction ring (HP:0009775)	6.55502305
2	Abnormality of placental membranes (HP:0011409)	6.55502305
3	Popliteal pterygium (HP:0009756)	6.08663954
4	Type 2 muscle fiber atrophy (HP:0003554)	5.62462211
5	Muscle fiber atrophy (HP:0100295)	4.79570722
6	Fetal akinesia sequence (HP:0001989)	4.61719408
7	Fatigable weakness (HP:0003473)	4.10919534
8	Abnormality of the neuromuscular junction (HP:0003398)	4.10919534
9	Abnormal hair whorl (HP:0010721)	3.79357206
10	Intestinal atresia (HP:0011100)	3.57353998
11	Aplasia of the musculature (HP:0100854)	3.56730141
12	Weak cry (HP:0001612)	3.29583453
13	Cystic hygroma (HP:0000476)	3.20344188
14	Aplasia/Hypoplasia involving the musculature (HP:0001460)	3.02087600
15	Hypoproteinemia (HP:0003075)	2.98026299
16	True hermaphroditism (HP:0010459)	2.96053619
17	Sex reversal (HP:0012245)	2.95434333
18	Abnormal sex determination (HP:0012244)	2.95434333
19	Akinesia (HP:0002304)	2.73065856
20	Atonic seizures (HP:0010819)	2.72257407
21	Volvulus (HP:0002580)	2.68626583
22	Gowers sign (HP:0003391)	2.65275746
23	Thin ribs (HP:0000883)	2.62723763
24	Poor eye contact (HP:0000817)	2.61110729
25	Aqueductal stenosis (HP:0002410)	2.60680440
26	Pancreatic cysts (HP:0001737)	2.54606587
27	Glucose intolerance (HP:0000833)	2.51847038
28	Long clavicles (HP:0000890)	2.51252752
29	Malignant hyperthermia (HP:0002047)	2.48085362
30	Acute necrotizing encephalopathy (HP:0006965)	2.47168813
31	Easy fatigability (HP:0003388)	2.43895633
32	Inability to walk (HP:0002540)	2.40399385
33	Progressive macrocephaly (HP:0004481)	2.40035867
34	Abnormalities of placenta or umbilical cord (HP:0001194)	2.39188819
35	Neoplasm of the adrenal cortex (HP:0100641)	2.36807093
36	Methylmalonic acidemia (HP:0002912)	2.35465901
37	Hemiparesis (HP:0001269)	2.35379170
38	Acute encephalopathy (HP:0006846)	2.35297322
39	Hyperventilation (HP:0002883)	2.34931181
40	Anencephaly (HP:0002323)	2.34604167
41	Curly hair (HP:0002212)	2.27063100
42	Dialeptic seizures (HP:0011146)	2.24822650
43	Pendular nystagmus (HP:0012043)	2.21312393
44	Type I transferrin isoform profile (HP:0003642)	2.20626675
45	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.19758083
46	Gastrointestinal atresia (HP:0002589)	2.17710377
47	Hypoplastic iliac wings (HP:0002866)	2.16613769
48	Nephronophthisis (HP:0000090)	2.10590525
49	Pterygium (HP:0001059)	2.09754294
50	Meningioma (HP:0002858)	2.09746162
51	Short middle phalanx of the 5th finger (HP:0004220)	2.08137054
52	Fair hair (HP:0002286)	2.07906678
53	Absence seizures (HP:0002121)	2.00804597
54	Abnormal protein glycosylation (HP:0012346)	2.00659595
55	Abnormal glycosylation (HP:0012345)	2.00659595
56	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.00659595
57	Abnormal protein N-linked glycosylation (HP:0012347)	2.00659595
58	Small hand (HP:0200055)	1.99697554
59	Secondary amenorrhea (HP:0000869)	1.94271675
60	Esophageal atresia (HP:0002032)	1.93268159
61	Chronic hepatic failure (HP:0100626)	1.92950984
62	Abnormality of the renal medulla (HP:0100957)	1.91618756
63	Neoplasm of the oral cavity (HP:0100649)	1.91045630
64	Pancreatic fibrosis (HP:0100732)	1.90915693
65	CNS demyelination (HP:0007305)	1.90102552
66	Mesomelia (HP:0003027)	1.89442169
67	Hypobetalipoproteinemia (HP:0003563)	1.88911428
68	Abnormality of the antihelix (HP:0009738)	1.87792276
69	Poor suck (HP:0002033)	1.86583304
70	Fibular aplasia (HP:0002990)	1.85801341
71	Progressive inability to walk (HP:0002505)	1.85563111
72	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.84740608
73	Focal motor seizures (HP:0011153)	1.84399811
74	Decreased muscle mass (HP:0003199)	1.84211017
75	Sensory axonal neuropathy (HP:0003390)	1.82969063
76	Increased corneal curvature (HP:0100692)	1.82356837
77	Keratoconus (HP:0000563)	1.82356837
78	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.82069065
79	Depressed nasal tip (HP:0000437)	1.81515955
80	Diminished movement (HP:0002374)	1.79904434
81	Occipital encephalocele (HP:0002085)	1.79630720
82	Irregular vertebral endplates (HP:0003301)	1.79437834
83	Drooling (HP:0002307)	1.79221593
84	Hypoplastic heart (HP:0001961)	1.78082934
85	Thyroid carcinoma (HP:0002890)	1.77819056
86	Mitochondrial inheritance (HP:0001427)	1.76763019
87	Abnormal mitochondria in muscle tissue (HP:0008316)	1.76174256
88	Abnormal glucose tolerance (HP:0001952)	1.75522227
89	Broad alveolar ridges (HP:0000187)	1.74982833
90	Oligodactyly (hands) (HP:0001180)	1.72897925
91	Chorioretinal atrophy (HP:0000533)	1.72365415
92	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.72275733
93	Breast carcinoma (HP:0003002)	1.70976461
94	Stomach cancer (HP:0012126)	1.70580181
95	Exocrine pancreatic insufficiency (HP:0001738)	1.68332163
96	Methylmalonic aciduria (HP:0012120)	1.66609560
97	Hypoalbuminemia (HP:0003073)	1.66458992
98	Abnormal albumin level (HP:0012116)	1.66458992
99	Reduced subcutaneous adipose tissue (HP:0003758)	1.66216441
100	Male infertility (HP:0003251)	1.65742371

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MUSK	4.77730377
2	EIF2AK3	3.79650205
3	NUAK1	3.60043173
4	PRKD3	3.45952515
5	STK39	3.31946103
6	CCNB1	3.21789737
7	CASK	3.03497726
8	STK16	3.00786111
9	VRK2	2.97584958
10	EIF2AK1	2.80143651
11	OXSR1	2.73453947
12	FRK	2.65844200
13	BRSK2	2.61102785
14	MAPK13	2.42513116
15	TAF1	2.38948290
16	MST4	2.24300489
17	LIMK1	1.80016408
18	MKNK2	1.71514729
19	MARK1	1.70561050
20	MAP4K2	1.67905555
21	WNK3	1.59111898
22	GRK1	1.44998517
23	PLK2	1.44268955
24	PAK3	1.43468361
25	ZAK	1.39339384
26	TRIM28	1.26527986
27	ERBB3	1.18476282
28	BRSK1	1.17147572
29	MAP3K12	1.13860946
30	CAMKK2	1.06768269
31	MAP3K2	1.04222635
32	FER	1.03635305
33	VRK1	1.00017363
34	BMPR1B	0.92395720
35	WEE1	0.90498782
36	NTRK3	0.87196847
37	CSNK1G1	0.84301809
38	CSNK1G3	0.83820927
39	CSNK1A1L	0.83257682
40	BCR	0.81869380
41	PLK3	0.80576707
42	PRKCE	0.80535498
43	EIF2AK2	0.79119371
44	ROCK1	0.77252055
45	MYLK	0.75870711
46	PKN1	0.71530390
47	NME1	0.67047834
48	DYRK2	0.65766264
49	MKNK1	0.62060407
50	RAF1	0.61725195
51	PRKD2	0.61190774
52	DAPK1	0.58780241
53	MAPKAPK5	0.58763749
54	DMPK	0.58740962
55	SRPK1	0.57421985
56	CSNK1G2	0.57251999
57	GSK3A	0.55294075
58	GRK5	0.54459651
59	MELK	0.54267076
60	FGFR2	0.53829403
61	SMG1	0.53399236
62	MAP3K4	0.52268015
63	DYRK1A	0.51837782
64	TAOK3	0.51837623
65	CDK9	0.51196084
66	PIK3CG	0.50139620
67	ADRBK2	0.49157021
68	PHKG2	0.44206392
69	PHKG1	0.44206392
70	LMTK2	0.43972157
71	CAMK2D	0.43860533
72	KSR1	0.43313718
73	CDK8	0.42417890
74	PRKCG	0.42229348
75	NTRK2	0.40441651
76	INSRR	0.38656791
77	PRKCQ	0.38564872
78	PRKDC	0.36897842
79	ROCK2	0.36540650
80	SGK2	0.34548504
81	STK11	0.32635714
82	ERBB2	0.32592924
83	MAP3K14	0.31850310
84	ILK	0.31495227
85	PRKCH	0.31426997
86	STK38L	0.29469082
87	IKBKB	0.29221505
88	SIK3	0.28726661
89	CSNK1A1	0.28723667
90	IGF1R	0.28615085
91	CSNK2A2	0.27496602
92	PRKCI	0.27295970
93	STK4	0.27246433
94	CHEK2	0.25069770
95	CHUK	0.24782262
96	MAPK7	0.23696894
97	PRKACA	0.22975532
98	ABL1	0.22819178
99	WNK1	0.22367437
100	ADRBK1	0.22081476

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	5.57441200
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.63791792
3	Proteasome_Homo sapiens_hsa03050	3.36449740
4	Propanoate metabolism_Homo sapiens_hsa00640	2.99228075
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.61375301
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.59583641
7	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.55770830
8	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.18825111
9	Folate biosynthesis_Homo sapiens_hsa00790	2.17366401
10	Steroid biosynthesis_Homo sapiens_hsa00100	2.09835115
11	Butanoate metabolism_Homo sapiens_hsa00650	2.02394636
12	Mineral absorption_Homo sapiens_hsa04978	1.97575141
13	RNA polymerase_Homo sapiens_hsa03020	1.90739425
14	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.75206628
15	Sulfur metabolism_Homo sapiens_hsa00920	1.59153142
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.54367924
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.50812612
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.43659043
19	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.43218225
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.41770844
21	Salivary secretion_Homo sapiens_hsa04970	1.39148619
22	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.36876578
23	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.29437052
24	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.25779329
25	Parkinsons disease_Homo sapiens_hsa05012	1.24019435
26	Nicotine addiction_Homo sapiens_hsa05033	1.23302971
27	Pancreatic secretion_Homo sapiens_hsa04972	1.20464386
28	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.18756312
29	Melanoma_Homo sapiens_hsa05218	1.16750710
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.15783684
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13638352
32	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.11223276
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.09492025
34	PPAR signaling pathway_Homo sapiens_hsa03320	1.04564077
35	Fatty acid elongation_Homo sapiens_hsa00062	1.01339621
36	Fanconi anemia pathway_Homo sapiens_hsa03460	0.98160607
37	Sulfur relay system_Homo sapiens_hsa04122	0.97666035
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.95969176
39	GABAergic synapse_Homo sapiens_hsa04727	0.95156532
40	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.95084473
41	Tryptophan metabolism_Homo sapiens_hsa00380	0.95037662
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93450304
43	Fatty acid metabolism_Homo sapiens_hsa01212	0.92363486
44	Circadian rhythm_Homo sapiens_hsa04710	0.91478103
45	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.87326959
46	Cardiac muscle contraction_Homo sapiens_hsa04260	0.86675466
47	Pyruvate metabolism_Homo sapiens_hsa00620	0.86197442
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.86006557
49	Huntingtons disease_Homo sapiens_hsa05016	0.85002306
50	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80954599
51	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.77803834
52	Alzheimers disease_Homo sapiens_hsa05010	0.72581905
53	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.72374392
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.71182967
55	Homologous recombination_Homo sapiens_hsa03440	0.70972614
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67923170
57	Gap junction_Homo sapiens_hsa04540	0.67378288
58	Basal transcription factors_Homo sapiens_hsa03022	0.66989045
59	Fatty acid degradation_Homo sapiens_hsa00071	0.66463604
60	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.61113348
61	RNA degradation_Homo sapiens_hsa03018	0.60288530
62	Insulin secretion_Homo sapiens_hsa04911	0.57032183
63	Peroxisome_Homo sapiens_hsa04146	0.55644522
64	Bile secretion_Homo sapiens_hsa04976	0.55443889
65	Wnt signaling pathway_Homo sapiens_hsa04310	0.54576036
66	Nitrogen metabolism_Homo sapiens_hsa00910	0.52886916
67	Gastric acid secretion_Homo sapiens_hsa04971	0.52546002
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52149054
69	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52018726
70	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.51490398
71	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.50463884
72	Sphingolipid metabolism_Homo sapiens_hsa00600	0.50404666
73	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.50126430
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.49821031
75	Prostate cancer_Homo sapiens_hsa05215	0.49796424
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.48315555
77	Linoleic acid metabolism_Homo sapiens_hsa00591	0.45926523
78	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.44577756
79	Vibrio cholerae infection_Homo sapiens_hsa05110	0.43611256
80	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43216243
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.43100883
82	Complement and coagulation cascades_Homo sapiens_hsa04610	0.41038531
83	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.39820979
84	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.36875230
85	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.36293003
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.36024925
87	Serotonergic synapse_Homo sapiens_hsa04726	0.33736751
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.32979879
89	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.32152494
90	Taste transduction_Homo sapiens_hsa04742	0.31686997
91	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.31255381
92	Histidine metabolism_Homo sapiens_hsa00340	0.31246366
93	Metabolic pathways_Homo sapiens_hsa01100	0.30841687
94	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.29673042
95	Purine metabolism_Homo sapiens_hsa00230	0.29141868
96	Pyrimidine metabolism_Homo sapiens_hsa00240	0.28954513
97	Phototransduction_Homo sapiens_hsa04744	0.28654505
98	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.28177700
99	Morphine addiction_Homo sapiens_hsa05032	0.26792110
100	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.26585778

USF1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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