USH1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a scaffold protein that functions in the assembly of Usher protein complexes. The protein contains PDZ domains, a coiled-coil region with a bipartite nuclear localization signal and a PEST degradation sequence. Defects in this gene are the cause of Usher syndrome type 1C and non-syndromic sensorineural deafness autosomal recessive type 18. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)6.63864177
2regulation of guanylate cyclase activity (GO:0031282)6.43991545
3COPI coating of Golgi vesicle (GO:0048205)6.06699345
4Golgi transport vesicle coating (GO:0048200)6.06699345
5epoxygenase P450 pathway (GO:0019373)5.38088974
6drug transmembrane transport (GO:0006855)5.26620995
7intestinal cholesterol absorption (GO:0030299)5.20651496
8endocrine pancreas development (GO:0031018)5.15903869
9purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.04847681
103-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.04847681
11peptide hormone processing (GO:0016486)4.90979982
12pentose metabolic process (GO:0019321)4.82456099
13positive regulation of guanylate cyclase activity (GO:0031284)4.80406272
14intestinal epithelial cell development (GO:0060576)4.72437491
15angiotensin maturation (GO:0002003)4.63301840
16fat-soluble vitamin biosynthetic process (GO:0042362)4.47680953
17COPII vesicle coating (GO:0048208)4.37764148
18drug transport (GO:0015893)4.37594816
19cellular response to vitamin D (GO:0071305)4.34917585
20lipoprotein transport (GO:0042953)4.32761802
21cellular glucuronidation (GO:0052695)4.22770046
22uronic acid metabolic process (GO:0006063)4.17807693
23glucuronate metabolic process (GO:0019585)4.17807693
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.16002519
25regulation of systemic arterial blood pressure (GO:0003073)4.14184177
26receptor guanylyl cyclase signaling pathway (GO:0007168)4.12504565
27glandular epithelial cell differentiation (GO:0002067)4.12013190
28drug metabolic process (GO:0017144)4.10263733
29UDP-N-acetylglucosamine metabolic process (GO:0006047)4.04223146
30regulation of cGMP biosynthetic process (GO:0030826)4.03976254
31regulation of Golgi to plasma membrane protein transport (GO:0042996)4.01287431
32flavonoid metabolic process (GO:0009812)3.99382628
33urea cycle (GO:0000050)3.99337275
34retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.94128204
35regulation of cellular extravasation (GO:0002691)3.93720770
36membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.92929563
37fructose metabolic process (GO:0006000)3.91633736
38peptide catabolic process (GO:0043171)3.90621717
39drug catabolic process (GO:0042737)3.87391889
40urea metabolic process (GO:0019627)3.79263772
41diacylglycerol metabolic process (GO:0046339)3.76900009
42bile acid and bile salt transport (GO:0015721)3.76197091
43response to hepatocyte growth factor (GO:0035728)3.71317393
44cellular response to hepatocyte growth factor stimulus (GO:0035729)3.71317393
45positive regulation of pseudopodium assembly (GO:0031274)3.70795974
46renal absorption (GO:0070293)3.69052345
47protein retention in ER lumen (GO:0006621)3.68771343
48renal system process involved in regulation of blood volume (GO:0001977)3.60208685
49calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.60125096
50columnar/cuboidal epithelial cell development (GO:0002066)3.58766561
51sequestering of metal ion (GO:0051238)3.57857626
52regulation of extracellular matrix disassembly (GO:0010715)3.56918145
53positive regulation of respiratory burst (GO:0060267)3.55379615
54regulation of bile acid biosynthetic process (GO:0070857)3.51607303
55regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.50749641
56sphingomyelin metabolic process (GO:0006684)3.49238552
57very-low-density lipoprotein particle assembly (GO:0034379)3.46582592
58cytidine metabolic process (GO:0046087)3.45898269
59cytidine catabolic process (GO:0006216)3.45898269
60cytidine deamination (GO:0009972)3.45898269
61endocardial cushion morphogenesis (GO:0003203)3.44898698
62membrane repolarization during action potential (GO:0086011)3.44605191
63nitrogen cycle metabolic process (GO:0071941)3.41975891
64antibacterial humoral response (GO:0019731)3.41126283
65positive regulation of insulin secretion (GO:0032024)3.40903846
66digestive system process (GO:0022600)3.40740497
67ethanol oxidation (GO:0006069)3.38987524
68positive regulation of glycoprotein biosynthetic process (GO:0010560)3.38948672
69vitamin transport (GO:0051180)3.37809366
70O-glycan processing (GO:0016266)3.37289624
71actin filament depolymerization (GO:0030042)3.36820065
72negative regulation of keratinocyte proliferation (GO:0010839)3.34411053
73regulation of pseudopodium assembly (GO:0031272)3.32852441
74glycosylceramide metabolic process (GO:0006677)3.30981728
75digestion (GO:0007586)3.30734491
76signal peptide processing (GO:0006465)3.29619437
77regulation of cholesterol homeostasis (GO:2000188)3.29335556
78antimicrobial humoral response (GO:0019730)3.29189123
79pyrimidine ribonucleoside catabolic process (GO:0046133)3.27295775
80regulation of cGMP metabolic process (GO:0030823)3.27096716
81* auditory receptor cell differentiation (GO:0042491)3.26468617
82glutamine family amino acid biosynthetic process (GO:0009084)3.25015978
83urate metabolic process (GO:0046415)3.23963323
84fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.23844197
85desmosome organization (GO:0002934)3.23376702
86glycolipid catabolic process (GO:0019377)3.23193026
87virion attachment to host cell (GO:0019062)3.21136821
88adhesion of symbiont to host cell (GO:0044650)3.21136821
89transcytosis (GO:0045056)3.20869933
90glycosphingolipid catabolic process (GO:0046479)3.20496616
91regulation of vitamin metabolic process (GO:0030656)3.20169456
92bundle of His cell to Purkinje myocyte communication (GO:0086069)3.19999520
93plasma lipoprotein particle assembly (GO:0034377)3.19456669
94regulation of triglyceride catabolic process (GO:0010896)3.19006453
95alkaloid metabolic process (GO:0009820)3.18286485
96phenylpropanoid metabolic process (GO:0009698)3.16074876
97protein targeting to Golgi (GO:0000042)3.13796425
98arginine metabolic process (GO:0006525)3.13749035
99epithelial structure maintenance (GO:0010669)3.13313535
100regulation of somitogenesis (GO:0014807)3.13283175
101sulfation (GO:0051923)3.11213657
102hormone catabolic process (GO:0042447)3.11186036
103glucose 6-phosphate metabolic process (GO:0051156)3.11153770
104regulation of cholesterol esterification (GO:0010872)3.10330646
105cellular response to vitamin (GO:0071295)3.08983845
106positive regulation of glycoprotein metabolic process (GO:1903020)3.08435635
107vitamin transmembrane transport (GO:0035461)3.08333611
108cGMP-mediated signaling (GO:0019934)3.05495500
109glomerular filtration (GO:0003094)3.04007150
110macroautophagy (GO:0016236)3.02266103
111homocysteine metabolic process (GO:0050667)3.01438909
112sphingolipid catabolic process (GO:0030149)3.01190694
113high-density lipoprotein particle remodeling (GO:0034375)2.98408099
114maintenance of gastrointestinal epithelium (GO:0030277)2.98327862
115epithelial cell fate commitment (GO:0072148)2.96806375
116exogenous drug catabolic process (GO:0042738)2.96675375
117lysine metabolic process (GO:0006553)2.96128890
118lysine catabolic process (GO:0006554)2.96128890
119negative regulation of digestive system process (GO:0060457)2.94733240
120protein-lipid complex assembly (GO:0065005)2.94166206
121phospholipid efflux (GO:0033700)2.94108577
122organic cation transport (GO:0015695)2.94070195
123cellular response to nutrient (GO:0031670)2.92593976
124positive regulation of cGMP biosynthetic process (GO:0030828)2.90673294
125ribonucleoside bisphosphate metabolic process (GO:0033875)2.90259145
126nucleoside bisphosphate metabolic process (GO:0033865)2.90259145
127purine nucleoside bisphosphate metabolic process (GO:0034032)2.90259145
128NADH metabolic process (GO:0006734)2.89763850
129regulation of protein glycosylation (GO:0060049)2.88565658
130sulfur compound transport (GO:0072348)2.87340165
131aminoglycoside antibiotic metabolic process (GO:0030647)2.87146841
132vesicle coating (GO:0006901)2.87143503
133lipoprotein metabolic process (GO:0042157)2.86810359
134vitamin A metabolic process (GO:0006776)2.86531943
135oligosaccharide catabolic process (GO:0009313)2.85701518
136nucleoside diphosphate biosynthetic process (GO:0009133)2.85133222
137phosphate ion transport (GO:0006817)2.85066766
138bile acid metabolic process (GO:0008206)2.84616745
139bicarbonate transport (GO:0015701)2.84033915
140vitamin biosynthetic process (GO:0009110)2.84033701
141cGMP biosynthetic process (GO:0006182)2.83957224
142protein autoprocessing (GO:0016540)2.82849769
143tricarboxylic acid metabolic process (GO:0072350)2.82567094
144oligosaccharide biosynthetic process (GO:0009312)2.81925580
145sulfate transmembrane transport (GO:1902358)2.81445192
146cobalamin metabolic process (GO:0009235)2.81159516
147membrane lipid catabolic process (GO:0046466)2.80953101
148fat-soluble vitamin metabolic process (GO:0006775)2.80667883
149reverse cholesterol transport (GO:0043691)2.80600056
150type B pancreatic cell development (GO:0003323)2.80338262
151phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.80162177
152regulation of type B pancreatic cell apoptotic process (GO:2000674)2.78442137
153regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.77794036
154endocrine process (GO:0050886)2.77794036
155regulation of systemic arterial blood pressure by hormone (GO:0001990)2.77794036
156fucose metabolic process (GO:0006004)2.77488485
157glandular epithelial cell development (GO:0002068)2.77346355
158retrograde transport, vesicle recycling within Golgi (GO:0000301)2.77010037
159modified amino acid transport (GO:0072337)2.72912505
160galactose catabolic process (GO:0019388)2.72763204
161positive regulation of peptide hormone secretion (GO:0090277)2.70536303
162L-alpha-amino acid transmembrane transport (GO:1902475)2.70101763
163activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.68109898
164establishment of protein localization to Golgi (GO:0072600)2.67639910
165intra-Golgi vesicle-mediated transport (GO:0006891)2.66601943
166mesenchyme morphogenesis (GO:0072132)2.64628965
167GDP-mannose metabolic process (GO:0019673)2.64375529
168inner ear receptor cell development (GO:0060119)2.64309571
169positive regulation of glycolytic process (GO:0045821)2.62769094
170beta-amyloid metabolic process (GO:0050435)2.62379791
171protein localization to Golgi apparatus (GO:0034067)2.61982874
172peptide metabolic process (GO:0006518)2.60125733

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.78187842
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.39992006
3CDX2_20551321_ChIP-Seq_CACO-2_Human3.61663200
4SOX2_27498859_Chip-Seq_STOMACH_Mouse3.56803037
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.98822301
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.61261792
7GATA4_25053715_ChIP-Seq_YYC3_Human2.60047205
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.52186462
9HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.40309027
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37636838
11SOX2_20726797_ChIP-Seq_SW620_Human2.37378496
12GATA6_25053715_ChIP-Seq_YYC3_Human2.34788150
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25645733
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.24605974
15FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.16601391
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.15651383
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.13577003
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.96904506
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.92799283
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.91908732
21ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.88726578
22ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.84457913
23ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.83110699
24GATA1_22025678_ChIP-Seq_K562_Human1.68898526
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67364447
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67114183
27RUNX1_27514584_Chip-Seq_MCF-7_Human1.57253331
28FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.53424898
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53358496
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52667132
31DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.52662435
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.51687500
33CLOCK_20551151_ChIP-Seq_293T_Human1.51163425
34AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.50049028
35RACK7_27058665_Chip-Seq_MCF-7_Human1.47575736
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47311133
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.45302106
38GATA3_24758297_ChIP-Seq_MCF-7_Human1.41301379
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.40541191
40VDR_22108803_ChIP-Seq_LS180_Human1.38673981
41CDX2_22108803_ChIP-Seq_LS180_Human1.36174573
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34310119
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.33552291
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32714453
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29717423
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29330937
47LXR_22292898_ChIP-Seq_THP-1_Human1.27739238
48TCF4_18268006_ChIP-ChIP_LS174T_Human1.27480128
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27324387
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23095297
51HNF4A_19822575_ChIP-Seq_HepG2_Human1.22637067
52DROSHA_22980978_ChIP-Seq_HELA_Human1.21488356
53KLF5_25053715_ChIP-Seq_YYC3_Human1.20746324
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18274765
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17432366
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15848111
57ZNF263_19887448_ChIP-Seq_K562_Human1.14979464
58CREB1_26743006_Chip-Seq_LNCaP_Human1.13553510
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12580303
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12443129
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.10602311
62CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09727070
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09288591
64FOXA1_25552417_ChIP-Seq_VCAP_Human1.09112876
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.09070216
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08266345
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04592089
68ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03305297
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02795627
70FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01987762
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00051546
72ATF3_27146783_Chip-Seq_COLON_Human0.99694992
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99077445
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98272431
75* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96222935
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95026787
77* CTCF_27219007_Chip-Seq_Bcells_Human0.94839689
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93500763
79AHR_22903824_ChIP-Seq_MCF-7_Human0.91987082
80BCAT_22108803_ChIP-Seq_LS180_Human0.91167581
81WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91027874
82FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89780061
83BCOR_27268052_Chip-Seq_Bcells_Human0.89269020
84EZH2_27294783_Chip-Seq_ESCs_Mouse0.87937305
85TBX20_22328084_ChIP-Seq_HEART_Mouse0.87367225
86TBX20_22080862_ChIP-Seq_HEART_Mouse0.87367225
87SA1_27219007_Chip-Seq_Bcells_Human0.87178845
88TP63_22573176_ChIP-Seq_HFKS_Human0.86907027
89RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86878291
90OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86729629
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86297272
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86231105
93* EP300_21415370_ChIP-Seq_HL-1_Mouse0.85164175
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85130416
95FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85021918
96BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.84965938
97TET1_21451524_ChIP-Seq_MESCs_Mouse0.84195091
98SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84104597
99RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84055756
100SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83759412
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.83318891
102RXR_22108803_ChIP-Seq_LS180_Human0.83072980
103NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81063906
104CEBPB_22108803_ChIP-Seq_LS180_Human0.80394977
105ERG_21242973_ChIP-ChIP_JURKAT_Human0.80368024
106IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80175755
107SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77981504
108FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.77973794
109ISL1_27105846_Chip-Seq_CPCs_Mouse0.77609376
110CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77113819
111FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.76311678
112BCL6_27268052_Chip-Seq_Bcells_Human0.75911826
113CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.75660173
114STAT1_20625510_ChIP-Seq_HELA_Human0.74657538
115KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73821688
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73649621
117SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.73465564
118NR3C1_23031785_ChIP-Seq_PC12_Mouse0.73411118
119FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73272230
120SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73231721
121GATA1_19941826_ChIP-Seq_K562_Human0.71927483
122* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.71850190
123CTNNB1_20460455_ChIP-Seq_HCT116_Human0.71615864
124SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71354242
125GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.70907512
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.70830633
127ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.70779422
128JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.69591436
129TP63_23658742_ChIP-Seq_EP156T_Human0.69278064
130TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.69050000
131NANOG_20526341_ChIP-Seq_ESCs_Human0.68605818
132GATA2_19941826_ChIP-Seq_K562_Human0.68394767
133PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.68228041
134TCF4_22108803_ChIP-Seq_LS180_Human0.67195292

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.31494392
2MP0003878_abnormal_ear_physiology5.31494392
3MP0004043_abnormal_pH_regulation5.07424446
4MP0005360_urolithiasis4.70176224
5MP0004264_abnormal_extraembryonic_tissu3.85593641
6MP0003283_abnormal_digestive_organ3.25809757
7MP0001666_abnormal_nutrient_absorption3.13585739
8MP0003183_abnormal_peptide_metabolism3.09384167
9MP0010234_abnormal_vibrissa_follicle2.84936348
10MP0009780_abnormal_chondrocyte_physiolo2.77390002
11MP0004147_increased_porphyrin_level2.76820383
12MP0003252_abnormal_bile_duct2.73624621
13MP0002139_abnormal_hepatobiliary_system2.59304108
14MP0003195_calcinosis2.51582008
15MP0009379_abnormal_foot_pigmentation2.51427021
16* MP0001485_abnormal_pinna_reflex2.40923127
17* MP0003879_abnormal_hair_cell2.38384295
18MP0000678_abnormal_parathyroid_gland2.31160828
19MP0001765_abnormal_ion_homeostasis2.27931681
20MP0000462_abnormal_digestive_system2.20711877
21MP0000013_abnormal_adipose_tissue2.17330117
22MP0009643_abnormal_urine_homeostasis2.15775859
23MP0005409_darkened_coat_color2.12579326
24MP0004019_abnormal_vitamin_homeostasis2.08678719
25MP0005085_abnormal_gallbladder_physiolo2.07060226
26MP0003866_abnormal_defecation2.03779910
27MP0001944_abnormal_pancreas_morphology1.88927106
28MP0002877_abnormal_melanocyte_morpholog1.84906587
29MP0003300_gastrointestinal_ulcer1.80619726
30MP0005365_abnormal_bile_salt1.79261765
31MP0002693_abnormal_pancreas_physiology1.78742178
32MP0005220_abnormal_exocrine_pancreas1.77921442
33MP0010386_abnormal_urinary_bladder1.74918751
34MP0002138_abnormal_hepatobiliary_system1.73613201
35MP0005636_abnormal_mineral_homeostasis1.60804061
36MP0000538_abnormal_urinary_bladder1.57944420
37MP0005084_abnormal_gallbladder_morpholo1.57017294
38MP0008875_abnormal_xenobiotic_pharmacok1.55239161
39MP0001756_abnormal_urination1.52213455
40MP0005332_abnormal_amino_acid1.45981685
41MP0002909_abnormal_adrenal_gland1.45455128
42MP0002837_dystrophic_cardiac_calcinosis1.42028617
43* MP0001963_abnormal_hearing_physiology1.40072560
44MP0005166_decreased_susceptibility_to1.39444823
45* MP0000026_abnormal_inner_ear1.37227400
46MP0008961_abnormal_basal_metabolism1.36020287
47MP0001501_abnormal_sleep_pattern1.26726627
48MP0002078_abnormal_glucose_homeostasis1.21730711
49MP0001664_abnormal_digestion1.20382661
50MP0006072_abnormal_retinal_apoptosis1.19144382
51MP0001188_hyperpigmentation1.17967050
52MP0005381_digestive/alimentary_phenotyp1.17737033
53MP0010678_abnormal_skin_adnexa1.16985850
54MP0005058_abnormal_lysosome_morphology1.16043991
55MP0002928_abnormal_bile_duct1.15919460
56MP0000613_abnormal_salivary_gland1.15084154
57MP0000003_abnormal_adipose_tissue1.15069878
58MP0001849_ear_inflammation1.14789811
59MP0002896_abnormal_bone_mineralization1.11286781
60MP0004782_abnormal_surfactant_physiolog1.07309975
61MP0002089_abnormal_postnatal_growth/wei1.06925158
62MP0004885_abnormal_endolymph1.06426459
63MP0001663_abnormal_digestive_system1.04658029
64MP0003941_abnormal_skin_development1.04070563
65MP0005670_abnormal_white_adipose1.03050573
66MP0005379_endocrine/exocrine_gland_phen1.01447945
67MP0002822_catalepsy1.00224877
68MP0002876_abnormal_thyroid_physiology0.97733880
69MP0002971_abnormal_brown_adipose0.96772139
70MP0002136_abnormal_kidney_physiology0.96762470
71MP0008872_abnormal_physiological_respon0.96617140
72MP0000477_abnormal_intestine_morphology0.94299163
73MP0002653_abnormal_ependyma_morphology0.91840191
74MP0000537_abnormal_urethra_morphology0.87351034
75MP0003868_abnormal_feces_composition0.87051712
76MP0003953_abnormal_hormone_level0.86488264
77MP0002277_abnormal_respiratory_mucosa0.85528053
78MP0004858_abnormal_nervous_system0.84621576
79MP0000566_synostosis0.84591079
80MP0010329_abnormal_lipoprotein_level0.81865507
81MP0010155_abnormal_intestine_physiology0.80686870
82MP0002796_impaired_skin_barrier0.80183306
83MP0005584_abnormal_enzyme/coenzyme_acti0.79192901
84MP0009840_abnormal_foam_cell0.78586810
85MP0005448_abnormal_energy_balance0.77187619
86MP0002098_abnormal_vibrissa_morphology0.76138161
87MP0003119_abnormal_digestive_system0.74328529
88MP0005645_abnormal_hypothalamus_physiol0.73740438
89MP0005451_abnormal_body_composition0.73667317
90MP0000230_abnormal_systemic_arterial0.73472288
91MP0004270_analgesia0.73394304
92MP0002166_altered_tumor_susceptibility0.72973202
93MP0003718_maternal_effect0.71404808
94MP0000467_abnormal_esophagus_morphology0.70765559
95MP0009384_cardiac_valve_regurgitation0.69408872
96MP0006054_spinal_hemorrhage0.67349890
97MP0002118_abnormal_lipid_homeostasis0.67082159
98MP0001873_stomach_inflammation0.66981700
99MP0010352_gastrointestinal_tract_polyps0.65367807
100MP0005310_abnormal_salivary_gland0.64013281
101MP0005375_adipose_tissue_phenotype0.63510011
102MP0000490_abnormal_crypts_of0.62614822
103MP0002254_reproductive_system_inflammat0.59989540
104MP0003191_abnormal_cellular_cholesterol0.58955140
105MP0002638_abnormal_pupillary_reflex0.58828040
106MP0001845_abnormal_inflammatory_respons0.58156553
107MP0000470_abnormal_stomach_morphology0.58078536
108MP0005319_abnormal_enzyme/_coenzyme0.57190304
109MP0003806_abnormal_nucleotide_metabolis0.56303391
110MP0000579_abnormal_nail_morphology0.56041855
111MP0009115_abnormal_fat_cell0.54886832
112MP0009642_abnormal_blood_homeostasis0.54302879
113MP0003638_abnormal_response/metabolism_0.54287878
114MP0006082_CNS_inflammation0.54198217
115MP0000163_abnormal_cartilage_morphology0.54046822
116MP0000516_abnormal_urinary_system0.53919195
117MP0005367_renal/urinary_system_phenotyp0.53919195
118MP0003045_fibrosis0.52966652
119MP0002069_abnormal_eating/drinking_beha0.52826731
120MP0008004_abnormal_stomach_pH0.52662546
121MP0005257_abnormal_intraocular_pressure0.52125022
122MP0003329_amyloid_beta_deposits0.51461806
123MP0005535_abnormal_body_temperature0.50904248
124MP0005501_abnormal_skin_physiology0.50838087
125MP0000609_abnormal_liver_physiology0.50695849
126MP0008775_abnormal_heart_ventricle0.50473062
127MP0001764_abnormal_homeostasis0.50052285
128MP0005248_abnormal_Harderian_gland0.49002484
129MP0003172_abnormal_lysosome_physiology0.48155984
130MP0001270_distended_abdomen0.47452042
131MP0003705_abnormal_hypodermis_morpholog0.46554748

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)5.09588048
2Abnormality of chloride homeostasis (HP:0011422)4.65633574
3Symptomatic seizures (HP:0011145)4.53269842
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.45860377
5Hyperinsulinemic hypoglycemia (HP:0000825)4.39417932
6Hypoglycemic coma (HP:0001325)4.39277235
7Abnormality of the vitamin B12 metabolism (HP:0004341)4.36731083
8Metabolic alkalosis (HP:0200114)4.36206284
9Hypobetalipoproteinemia (HP:0003563)4.15289054
10Hypoglycemic seizures (HP:0002173)4.13975221
11Ketoacidosis (HP:0001993)4.11503755
12Chronic diarrhea (HP:0002028)4.06837265
13Unilateral renal agenesis (HP:0000122)3.95050874
14Fat malabsorption (HP:0002630)3.93374634
15Abnormality of renin-angiotensin system (HP:0000847)3.93182455
16Increased circulating renin level (HP:0000848)3.73261269
17Ileus (HP:0002595)3.72894955
18Late onset (HP:0003584)3.66202986
19Hypokalemia (HP:0002900)3.65722475
20Abdominal distention (HP:0003270)3.63995537
21Decreased circulating renin level (HP:0003351)3.44753466
22Abnormality of calcium-phosphate metabolism (HP:0100530)3.38210129
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.36521734
24Abnormality of monocarboxylic acid metabolism (HP:0010996)3.31565484
25Confusion (HP:0001289)3.29835479
26Systemic lupus erythematosus (HP:0002725)3.29591222
27Hyperaldosteronism (HP:0000859)3.28998678
28Proximal tubulopathy (HP:0000114)3.27652932
29Hyperparathyroidism (HP:0000843)3.25126477
30Hypokalemic alkalosis (HP:0001949)3.20521238
31Pigmentary retinal degeneration (HP:0001146)3.19240713
32Generalized aminoaciduria (HP:0002909)3.14624540
33Gout (HP:0001997)3.13650764
34Hyperglycemia (HP:0003074)3.12927579
35Abnormality of magnesium homeostasis (HP:0004921)3.12901213
36Enlarged epiphyses (HP:0010580)3.07387683
37Conjugated hyperbilirubinemia (HP:0002908)3.06413364
38Abnormality of potassium homeostasis (HP:0011042)3.04118603
39Glycosuria (HP:0003076)2.99899780
40Abnormality of urine glucose concentration (HP:0011016)2.99899780
41Protuberant abdomen (HP:0001538)2.99366906
42Xanthomatosis (HP:0000991)2.98038688
43Malnutrition (HP:0004395)2.96093241
44Hyperphosphaturia (HP:0003109)2.88834642
45Hypomagnesemia (HP:0002917)2.81576290
46Epiphyseal dysplasia (HP:0002656)2.78871876
47Hyperammonemia (HP:0001987)2.77640455
48Alkalosis (HP:0001948)2.76497332
49Abnormality of serine family amino acid metabolism (HP:0010894)2.74855445
50Abnormality of glycine metabolism (HP:0010895)2.74855445
51Abnormal urine output (HP:0012590)2.72165090
52Hypoplasia of the fovea (HP:0007750)2.69943212
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.69943212
54Focal segmental glomerulosclerosis (HP:0000097)2.69150324
55Abnormality of purine metabolism (HP:0004352)2.66134573
56Hydroxyprolinuria (HP:0003080)2.63332068
57Abnormality of proline metabolism (HP:0010907)2.63332068
58Hypoplastic ischia (HP:0003175)2.62707029
59Steatorrhea (HP:0002570)2.62100717
60Mixed hearing impairment (HP:0000410)2.61099273
61Widely patent fontanelles and sutures (HP:0004492)2.60404713
62Abnormality of renal excretion (HP:0011036)2.58147226
63Acanthocytosis (HP:0001927)2.56989557
64Abnormal pancreas size (HP:0012094)2.54804270
65Polyuria (HP:0000103)2.52744912
66Urinary glycosaminoglycan excretion (HP:0003541)2.52420036
67Mucopolysacchariduria (HP:0008155)2.52420036
68Hypophosphatemia (HP:0002148)2.52077803
69Abnormality of endocrine pancreas physiology (HP:0012093)2.49527206
70Abnormality of the pancreatic islet cells (HP:0006476)2.49527206
71Vascular calcification (HP:0004934)2.48570225
72Abnormal urine phosphate concentration (HP:0012599)2.48463938
73Ketosis (HP:0001946)2.47331034
74Hypercalciuria (HP:0002150)2.46795371
75Wide cranial sutures (HP:0010537)2.44376725
76Hemorrhage of the eye (HP:0011885)2.43646615
77Dysostosis multiplex (HP:0000943)2.43468978
78Adrenal overactivity (HP:0002717)2.42616103
79Vertebral clefting (HP:0008428)2.41101244
80Abnormal vertebral ossification (HP:0100569)2.40352100
81Growth hormone excess (HP:0000845)2.39518571
82Delayed epiphyseal ossification (HP:0002663)2.38962533
83Nausea (HP:0002018)2.38329260
84Facial shape deformation (HP:0011334)2.36032711
85Potter facies (HP:0002009)2.36032711
86Hypolipoproteinemia (HP:0010981)2.35936549
87Intrahepatic cholestasis (HP:0001406)2.34356241
88Right ventricular cardiomyopathy (HP:0011663)2.33114493
89Abnormality of the fovea (HP:0000493)2.32531389
90Megaloblastic anemia (HP:0001889)2.29584624
91Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.28886741
92Abnormality of the ischium (HP:0003174)2.27462361
93Hyperglycinuria (HP:0003108)2.26333356
94Abnormality of polysaccharide metabolism (HP:0011012)2.25418992
95Abnormality of glycosaminoglycan metabolism (HP:0004371)2.25418992
96Abnormality of mucopolysaccharide metabolism (HP:0011020)2.25418992
97Dicarboxylic aciduria (HP:0003215)2.24238856
98Abnormality of dicarboxylic acid metabolism (HP:0010995)2.24238856
99Insulin-resistant diabetes mellitus (HP:0000831)2.23131437
100Abnormality of vitamin B metabolism (HP:0004340)2.20165903
101Abnormal biliary tract morphology (HP:0012440)2.20020701
102Metabolic acidosis (HP:0001942)2.19624464
103Tetany (HP:0001281)2.18697307
104Pancreatic islet-cell hyperplasia (HP:0004510)2.17505037
105Nephrolithiasis (HP:0000787)2.16499615
106Pili torti (HP:0003777)2.16262415
107Dehydration (HP:0001944)2.15599367
108Flat acetabular roof (HP:0003180)2.13529062
109Hyperuricemia (HP:0002149)2.13445074
110Increased purine levels (HP:0004368)2.13445074
111Syncope (HP:0001279)2.13047850
112Abnormal tarsal ossification (HP:0008369)2.11835501
113Abnormality of nucleobase metabolism (HP:0010932)2.11686046
114Vacuolated lymphocytes (HP:0001922)2.11583269
115Hyperphosphatemia (HP:0002905)2.10700101
116Cardiovascular calcification (HP:0011915)2.10496388
117Progressive sensorineural hearing impairment (HP:0000408)2.09911782
118Exocrine pancreatic insufficiency (HP:0001738)2.09113049
119Abnormality of aromatic amino acid family metabolism (HP:0004338)2.08280438
120Hyperkalemia (HP:0002153)2.08151999
121Glomerulosclerosis (HP:0000096)2.08075029
122Abnormal drinking behavior (HP:0030082)2.04108887
123Polydipsia (HP:0001959)2.04108887
124Abnormal glucose tolerance (HP:0001952)2.03737236
125Double outlet right ventricle (HP:0001719)2.01226303
126Congenital malformation of the right heart (HP:0011723)2.01226303
127Large for gestational age (HP:0001520)2.00903042
128Abnormal albumin level (HP:0012116)2.00659032
129Hypoalbuminemia (HP:0003073)2.00659032
130Irritability (HP:0000737)1.99315990
131Abnormality of vitamin metabolism (HP:0100508)1.99237575
132Insulin resistance (HP:0000855)1.98501388
133Hypotension (HP:0002615)1.98191916
134Villous atrophy (HP:0011473)1.97695261
135Abnormality of small intestinal villus morphology (HP:0011472)1.97695261
136Thin bony cortex (HP:0002753)1.94549245
137Posterior subcapsular cataract (HP:0007787)1.93925542
138Aplasia/hypoplasia of the uterus (HP:0008684)1.91370728
139Osteomalacia (HP:0002749)1.89898548
140Abnormal hair laboratory examination (HP:0003328)1.86815744
141Glomerulonephritis (HP:0000099)1.86127152
142Increased CSF protein (HP:0002922)1.86019679
143Renal tubular acidosis (HP:0001947)1.85623537
144Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84831499

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.82928620
2DDR25.20084578
3WNK44.84477864
4WNK34.75150515
5MAPK154.44736719
6FRK4.38541346
7INSRR3.52592139
8MAP3K22.82137522
9LMTK22.43982116
10MAP2K22.19972108
11PASK2.11099911
12MST42.00706487
13RIPK11.99688643
14TAOK31.98505974
15NME11.97216415
16EPHA21.95800648
17ERN11.94994775
18PRKG21.83276735
19MAP3K121.82876507
20MST1R1.79020341
21MAP2K61.73109838
22STK241.60566251
23DYRK1B1.57178638
24PTK61.53872212
25HIPK21.48947222
26OXSR11.46119872
27CDC42BPA1.41004538
28PRKD31.33557267
29PTK21.31169234
30WNK11.29152214
31TNIK1.25611146
32AKT31.24400457
33BCKDK1.20428660
34PIK3CG1.19052853
35LATS11.14833154
36PRKCI1.14799396
37EPHB11.11024962
38MET1.10757323
39MAP3K101.09291113
40CASK1.07572068
41TESK11.03750739
42MAP3K31.02736631
43NLK1.02644146
44MAP3K11.00182139
45STK391.00047408
46PAK30.98736594
47FGFR20.97115682
48BRAF0.95604916
49PDGFRA0.94597589
50IRAK30.88160260
51DAPK20.84538094
52PIK3CA0.83402102
53STK38L0.81871561
54GRK60.81730605
55GRK10.81369102
56FER0.79892216
57NTRK10.78937689
58UHMK10.78792180
59TRIB30.73615006
60TYK20.70877922
61PHKG20.70790963
62PHKG10.70790963
63PRKAA10.67588162
64DMPK0.65149596
65NUAK10.64903328
66ERBB20.59647683
67EPHB20.59287188
68EPHA40.58462190
69MYLK0.58169204
70EPHA30.57469801
71FLT30.57197781
72BMPR20.54166160
73YES10.50379050
74FGFR40.49687102
75PRKAA20.48929901
76PDK10.48143620
77CAMK2G0.48112876
78KSR20.47350740
79PDPK10.46909316
80CAMK2D0.45671111
81MAP2K10.43847805
82MAPKAPK30.43672112
83PDK40.42578424
84PDK30.42578424
85BMX0.41790045
86SCYL20.41120104
87RPS6KA20.40616483
88PRKCZ0.39278457
89ABL20.39107602
90GSK3A0.37854060
91IRAK10.37358361
92SRC0.37009999
93DAPK10.33451539
94ARAF0.33122451
95PRKD20.33090586
96STK30.32122397
97NEK60.31510030
98TESK20.30904897
99CSK0.30825582
100PINK10.30575880
101CAMKK20.30575164
102NTRK30.30450727
103TAOK10.29930817
104CSNK1A10.28554168
105BRD40.28414179
106TBK10.27889496
107RET0.27814840
108PAK40.26336150
109ERBB40.25588955
110MTOR0.25386574
111MARK30.25167367
112RPS6KA10.25126049
113PRKCE0.25032003
114MAPK110.24658094
115PRKCA0.24513098
116PRKACG0.24264105
117MAP3K70.24167982
118JAK10.23351634
119ADRBK20.22450665
120BMPR1B0.22392897
121SIK10.22044499
122FGFR30.21897565
123PRKCQ0.20594326
124PDK20.20537780
125SGK10.20475883
126ROCK10.19803646
127CAMK2A0.17402914
128TRPM70.17180727
129SGK2230.16931978
130SGK4940.16931978
131MATK0.16403306
132MAP4K10.16367248
133RPS6KL10.15838690
134RPS6KC10.15838690
135CAMK2B0.15069700
136MAPKAPK20.14743047

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.48287969
2Sulfur metabolism_Homo sapiens_hsa009204.40946107
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.05225428
4Fat digestion and absorption_Homo sapiens_hsa049752.79924917
5Mineral absorption_Homo sapiens_hsa049782.50384059
6Arginine biosynthesis_Homo sapiens_hsa002202.49815444
7Carbohydrate digestion and absorption_Homo sapiens_hsa049732.30620096
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.27973055
9Protein export_Homo sapiens_hsa030602.10967576
10Galactose metabolism_Homo sapiens_hsa000521.97908371
11Protein digestion and absorption_Homo sapiens_hsa049741.96742388
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.94499945
13Folate biosynthesis_Homo sapiens_hsa007901.90777384
14Starch and sucrose metabolism_Homo sapiens_hsa005001.86955465
15Renin-angiotensin system_Homo sapiens_hsa046141.82956870
16Retinol metabolism_Homo sapiens_hsa008301.81448142
17Butanoate metabolism_Homo sapiens_hsa006501.80944050
18Vitamin digestion and absorption_Homo sapiens_hsa049771.78143236
19Tryptophan metabolism_Homo sapiens_hsa003801.73771872
20Insulin secretion_Homo sapiens_hsa049111.71396813
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65906160
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58933046
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.58258532
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58016063
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57041990
26Histidine metabolism_Homo sapiens_hsa003401.51415283
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50882405
28Fatty acid degradation_Homo sapiens_hsa000711.48950349
29Fructose and mannose metabolism_Homo sapiens_hsa000511.45491941
30Bile secretion_Homo sapiens_hsa049761.41231005
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39441029
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.37494975
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33633350
34Other glycan degradation_Homo sapiens_hsa005111.26054855
35Vibrio cholerae infection_Homo sapiens_hsa051101.20319958
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16928807
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12575885
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12364340
39Pyruvate metabolism_Homo sapiens_hsa006201.10270422
40Type II diabetes mellitus_Homo sapiens_hsa049301.09987681
41Selenocompound metabolism_Homo sapiens_hsa004501.08179782
42Ether lipid metabolism_Homo sapiens_hsa005651.06340596
43Lysine degradation_Homo sapiens_hsa003101.05522294
44Thyroid hormone synthesis_Homo sapiens_hsa049181.03204029
45Nitrogen metabolism_Homo sapiens_hsa009101.03043988
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02682393
47Sphingolipid metabolism_Homo sapiens_hsa006000.94601387
48Pancreatic secretion_Homo sapiens_hsa049720.92772047
49N-Glycan biosynthesis_Homo sapiens_hsa005100.88903775
50ABC transporters_Homo sapiens_hsa020100.87577689
51Arginine and proline metabolism_Homo sapiens_hsa003300.87407046
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86859468
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85667183
54Propanoate metabolism_Homo sapiens_hsa006400.85103304
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84114416
56Peroxisome_Homo sapiens_hsa041460.83650500
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81636644
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.77665377
59beta-Alanine metabolism_Homo sapiens_hsa004100.71475373
60Glycerolipid metabolism_Homo sapiens_hsa005610.70767569
61Tight junction_Homo sapiens_hsa045300.70035559
62PPAR signaling pathway_Homo sapiens_hsa033200.68471178
63Oxidative phosphorylation_Homo sapiens_hsa001900.68078666
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67523256
65Glutathione metabolism_Homo sapiens_hsa004800.67369493
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65016493
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.64348022
68Renin secretion_Homo sapiens_hsa049240.64150384
69Carbon metabolism_Homo sapiens_hsa012000.63188627
70Caffeine metabolism_Homo sapiens_hsa002320.63184902
71Phenylalanine metabolism_Homo sapiens_hsa003600.62166428
72Circadian rhythm_Homo sapiens_hsa047100.62157846
73Cocaine addiction_Homo sapiens_hsa050300.62141388
74Linoleic acid metabolism_Homo sapiens_hsa005910.60972112
75Sulfur relay system_Homo sapiens_hsa041220.60378441
76Bladder cancer_Homo sapiens_hsa052190.59994156
77Fatty acid metabolism_Homo sapiens_hsa012120.59870987
78Insulin resistance_Homo sapiens_hsa049310.59565845
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56913041
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52576926
81Lysosome_Homo sapiens_hsa041420.52392000
82Collecting duct acid secretion_Homo sapiens_hsa049660.50294682
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49570232
84Gastric acid secretion_Homo sapiens_hsa049710.48736568
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.48038000
86Parkinsons disease_Homo sapiens_hsa050120.47456077
87Alzheimers disease_Homo sapiens_hsa050100.47341758
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47044879
89Glucagon signaling pathway_Homo sapiens_hsa049220.43525635
90Tyrosine metabolism_Homo sapiens_hsa003500.41677848
91Asthma_Homo sapiens_hsa053100.41249983
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.41122944
93Fatty acid elongation_Homo sapiens_hsa000620.39134189
94Thyroid cancer_Homo sapiens_hsa052160.38064762
95Type I diabetes mellitus_Homo sapiens_hsa049400.37017323
96Vitamin B6 metabolism_Homo sapiens_hsa007500.36927745
97Inositol phosphate metabolism_Homo sapiens_hsa005620.36574575
98Metabolic pathways_Homo sapiens_hsa011000.36410560
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.35346629
100Arachidonic acid metabolism_Homo sapiens_hsa005900.33454922
101Dorso-ventral axis formation_Homo sapiens_hsa043200.29273269
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25530755
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.23883567
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23865123
105Fatty acid biosynthesis_Homo sapiens_hsa000610.23452828
106Cardiac muscle contraction_Homo sapiens_hsa042600.23077441
107Complement and coagulation cascades_Homo sapiens_hsa046100.21120148
108Amphetamine addiction_Homo sapiens_hsa050310.20101813
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.19925276
110Taste transduction_Homo sapiens_hsa047420.19740261
111Hepatitis C_Homo sapiens_hsa051600.19130559
112Adherens junction_Homo sapiens_hsa045200.16358300
113Insulin signaling pathway_Homo sapiens_hsa049100.16302464
114Estrogen signaling pathway_Homo sapiens_hsa049150.15772799
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15436428
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.15007694
117Prolactin signaling pathway_Homo sapiens_hsa049170.14945409
118Serotonergic synapse_Homo sapiens_hsa047260.14648289
119Staphylococcus aureus infection_Homo sapiens_hsa051500.14462194
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.13750642
121Chemical carcinogenesis_Homo sapiens_hsa052040.12854634
122Pentose phosphate pathway_Homo sapiens_hsa000300.12189287
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.11991388
124Autoimmune thyroid disease_Homo sapiens_hsa053200.09667030
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.08822164
126Allograft rejection_Homo sapiens_hsa053300.08733594
127Salivary secretion_Homo sapiens_hsa049700.08626775

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