USH1G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains three ankyrin domains, a class I PDZ-binding motif and a sterile alpha motif. The encoded protein interacts with harmonin, which is associated with Usher syndrome type 1C. This protein plays a role in the development and maintenance of the auditory and visual systems and functions in the cohesion of hair bundles formed by inner ear sensory cells. Mutations in this gene are associated with Usher syndrome type 1G (USH1G). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.70302418
2regulation of cilium movement (GO:0003352)5.39972535
3cell-cell junction maintenance (GO:0045217)5.34129246
4microtubule depolymerization (GO:0007019)5.24537905
5nucleobase catabolic process (GO:0046113)5.17115209
6head development (GO:0060322)5.01173015
7establishment of mitochondrion localization (GO:0051654)4.98667018
8mitochondrion transport along microtubule (GO:0047497)4.91166964
9establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.91166964
10G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.80784723
11calcium ion-dependent exocytosis (GO:0017156)4.72729549
12acrosome reaction (GO:0007340)4.60866921
13cell junction maintenance (GO:0034331)4.54986229
14sperm motility (GO:0030317)4.50781850
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.39432957
16regulation of microtubule-based movement (GO:0060632)4.27693010
17neurotransmitter-gated ion channel clustering (GO:0072578)4.25658642
18gamma-aminobutyric acid signaling pathway (GO:0007214)4.15583339
19neuron cell-cell adhesion (GO:0007158)4.15130585
20regulation of synapse maturation (GO:0090128)4.14969875
21microtubule polymerization or depolymerization (GO:0031109)4.12493710
22positive regulation of CREB transcription factor activity (GO:0032793)4.10445878
23behavioral response to nicotine (GO:0035095)4.07270747
24proline biosynthetic process (GO:0006561)4.03463487
25righting reflex (GO:0060013)3.98798495
26protein polyglutamylation (GO:0018095)3.93132542
27detection of light stimulus involved in visual perception (GO:0050908)3.89694758
28detection of light stimulus involved in sensory perception (GO:0050962)3.89694758
29urinary tract smooth muscle contraction (GO:0014848)3.84023877
30negative regulation of amino acid transport (GO:0051956)3.82031775
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.81541784
32secondary heart field specification (GO:0003139)3.80673889
33heart field specification (GO:0003128)3.80673889
34regulation of timing of cell differentiation (GO:0048505)3.79582100
35positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.76449158
36centriole replication (GO:0007099)3.74945043
37cardiac ventricle formation (GO:0003211)3.74700991
38positive regulation of synapse maturation (GO:0090129)3.72757362
39presynaptic membrane assembly (GO:0097105)3.71957381
40positive regulation of dendritic spine morphogenesis (GO:0061003)3.64673047
41regulation of collateral sprouting (GO:0048670)3.64627400
42protein localization to synapse (GO:0035418)3.60326727
43synaptic vesicle endocytosis (GO:0048488)3.56933600
44protein targeting to Golgi (GO:0000042)3.55902611
45axonemal dynein complex assembly (GO:0070286)3.50075161
46apoptotic DNA fragmentation (GO:0006309)3.48791780
47postsynaptic membrane organization (GO:0001941)3.47642302
48cardiac chamber formation (GO:0003207)3.47319860
49presynaptic membrane organization (GO:0097090)3.47267096
50microtubule nucleation (GO:0007020)3.47055766
51male sex determination (GO:0030238)3.44237773
52regulation of feeding behavior (GO:0060259)3.43857818
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.37919994
54spermatid development (GO:0007286)3.35509757
55establishment of protein localization to Golgi (GO:0072600)3.32903761
56regulation of development, heterochronic (GO:0040034)3.30299530
57regulation of glutamate secretion (GO:0014048)3.29184757
58regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.29103781
59forebrain neuron development (GO:0021884)3.28997965
60retrograde transport, vesicle recycling within Golgi (GO:0000301)3.27507091
61regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.24146340
62peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.24005343
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.22829472
64specification of organ identity (GO:0010092)3.21839296
65axoneme assembly (GO:0035082)3.21663595
66calcium ion import (GO:0070509)3.21409043
67startle response (GO:0001964)3.21025003
68positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.20837672
69glutamate receptor signaling pathway (GO:0007215)3.20176572
70spinal cord development (GO:0021510)3.18524820
71negative regulation of synaptic transmission, GABAergic (GO:0032229)3.16028169
72regulation of meiosis I (GO:0060631)3.14620228
73adenosine metabolic process (GO:0046085)3.13480365
74opioid receptor signaling pathway (GO:0038003)3.12669012
75epithelial cilium movement (GO:0003351)3.05852389
76retinal rod cell development (GO:0046548)3.05089978
77nonmotile primary cilium assembly (GO:0035058)3.03252496
78cellular potassium ion homeostasis (GO:0030007)3.00522558
79reflex (GO:0060004)2.98528820
80regulation of male gonad development (GO:2000018)2.98435074
81centriole assembly (GO:0098534)2.97858131
82limb bud formation (GO:0060174)2.96655562
83fusion of sperm to egg plasma membrane (GO:0007342)2.96539664
84cellular component maintenance (GO:0043954)2.93465165
85positive regulation of synaptic transmission, GABAergic (GO:0032230)2.93021049
86positive regulation of uterine smooth muscle contraction (GO:0070474)2.89489424
87regulation of synaptic vesicle exocytosis (GO:2000300)2.89416680
88neuronal action potential propagation (GO:0019227)2.84200380
89negative regulation of dendrite development (GO:2000171)2.83350000
90cerebral cortex radially oriented cell migration (GO:0021799)2.83262589
91neuronal ion channel clustering (GO:0045161)2.81462092
92negative regulation of homotypic cell-cell adhesion (GO:0034111)2.80501947
93ganglion development (GO:0061548)2.79392856
94microtubule bundle formation (GO:0001578)2.77694992
95retinal ganglion cell axon guidance (GO:0031290)2.77686337
96polarized epithelial cell differentiation (GO:0030859)2.77427764
97positive regulation of vascular permeability (GO:0043117)2.77388655
98nuclear pore complex assembly (GO:0051292)2.76540328
99adult feeding behavior (GO:0008343)2.76236170
100innervation (GO:0060384)2.75751654
101arginine catabolic process (GO:0006527)2.74975849
102regulation of neuron projection regeneration (GO:0070570)2.74924862
103regulation of axon regeneration (GO:0048679)2.74924862
104establishment or maintenance of monopolar cell polarity (GO:0061339)2.72760067
105establishment of monopolar cell polarity (GO:0061162)2.72760067
106positive regulation of cellular amide metabolic process (GO:0034250)2.71761497
107sphingoid metabolic process (GO:0046519)2.71341747
108positive regulation of meiosis (GO:0045836)2.70910608
109regulation of pigment cell differentiation (GO:0050932)2.70531553
110response to dietary excess (GO:0002021)2.69796854
111regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.69654142
112spinal cord motor neuron differentiation (GO:0021522)2.69038669
113kidney morphogenesis (GO:0060993)2.67745531
114daunorubicin metabolic process (GO:0044597)2.67706514
115polyketide metabolic process (GO:0030638)2.67706514
116doxorubicin metabolic process (GO:0044598)2.67706514
117polyamine biosynthetic process (GO:0006596)2.64857012
118cerebral cortex cell migration (GO:0021795)2.63809916
119diol metabolic process (GO:0034311)2.62990393
120positive regulation of meiotic cell cycle (GO:0051446)2.62506973
121negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.62157078
122ionotropic glutamate receptor signaling pathway (GO:0035235)2.61578550
123sympathetic nervous system development (GO:0048485)2.58676823
124positive regulation of amino acid transport (GO:0051957)2.58646175
125positive regulation of male gonad development (GO:2000020)2.57471083
126neuron-neuron synaptic transmission (GO:0007270)2.56510208
127neuromuscular synaptic transmission (GO:0007274)2.56392251
128proline metabolic process (GO:0006560)2.56210117
129multicellular organism reproduction (GO:0032504)2.55978784
130transmission of nerve impulse (GO:0019226)2.55774598
131vocalization behavior (GO:0071625)2.53956346
132cornea development in camera-type eye (GO:0061303)2.53481595
133regulation of respiratory system process (GO:0044065)2.53352006
134female gonad development (GO:0008585)2.52105269
135amino acid import (GO:0043090)2.52085715
136single strand break repair (GO:0000012)2.51969726
137regulation of synaptic vesicle transport (GO:1902803)2.50087680
138regulation of uterine smooth muscle contraction (GO:0070472)2.50005184
139synaptic transmission, cholinergic (GO:0007271)2.49979855
140nuclear pore organization (GO:0006999)2.49586429
141synaptic transmission, glutamatergic (GO:0035249)2.48880038
142regulation of glutamate receptor signaling pathway (GO:1900449)2.48707958
143regulation of neurotransmitter secretion (GO:0046928)2.48537168
144ear development (GO:0043583)2.47611605
145protein localization to Golgi apparatus (GO:0034067)2.47024112
146calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.45869584
147L-amino acid import (GO:0043092)2.45863763
148mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.44371825
149sphingosine metabolic process (GO:0006670)2.43721503
150cellular biogenic amine catabolic process (GO:0042402)2.43092237
151amine catabolic process (GO:0009310)2.43092237
152negative regulation of telomere maintenance (GO:0032205)2.42591069
153regulation of synaptic transmission, GABAergic (GO:0032228)2.42585790
154cilium or flagellum-dependent cell motility (GO:0001539)2.41420939
155long-term synaptic potentiation (GO:0060291)2.40976388
156long-term memory (GO:0007616)2.40900536
157positive regulation of cell size (GO:0045793)2.40409567
158behavioral response to ethanol (GO:0048149)2.40334446
159clathrin coat assembly (GO:0048268)2.39737987
160negative regulation of calcium ion transport into cytosol (GO:0010523)2.39483367
161detection of mechanical stimulus involved in sensory perception (GO:0050974)2.38136691
162long-chain fatty acid biosynthetic process (GO:0042759)2.37330581
163synaptic vesicle exocytosis (GO:0016079)2.37225717
164positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.36832545
165cell migration in hindbrain (GO:0021535)2.36795366
166keratinocyte development (GO:0003334)2.36476758
167synapse assembly (GO:0007416)2.36030231
168ubiquinone metabolic process (GO:0006743)2.35915396
169import into cell (GO:0098657)2.35704119
170hippocampus development (GO:0021766)2.35231048
171cerebellar Purkinje cell differentiation (GO:0021702)2.34978944
172ephrin receptor signaling pathway (GO:0048013)2.34091705
173cilium movement (GO:0003341)2.33036763
174microtubule severing (GO:0051013)2.32364783
175cerebellar granule cell differentiation (GO:0021707)2.31898067
176execution phase of apoptosis (GO:0097194)2.31892717
177sperm-egg recognition (GO:0035036)2.30975021
178positive regulation of mitochondrial fission (GO:0090141)2.30313246
179anterograde axon cargo transport (GO:0008089)2.29422084
180apical protein localization (GO:0045176)2.28707107
181neurofilament cytoskeleton organization (GO:0060052)2.26828287
182cardiac right ventricle morphogenesis (GO:0003215)2.26118860
183chemosensory behavior (GO:0007635)2.26091025
184microtubule anchoring (GO:0034453)2.25958119
185glycerol metabolic process (GO:0006071)2.24504133
186cell differentiation in hindbrain (GO:0021533)2.23785859

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.00602443
2GBX2_23144817_ChIP-Seq_PC3_Human3.83074867
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.09956615
4EZH2_22144423_ChIP-Seq_EOC_Human3.05001579
5ZNF274_21170338_ChIP-Seq_K562_Hela2.83043267
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69733012
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.65630913
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.53555925
9* EED_16625203_ChIP-ChIP_MESCs_Mouse2.44724291
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41744310
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40887561
12* EZH2_27304074_Chip-Seq_ESCs_Mouse2.39579313
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.39156482
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35702290
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35128577
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34793468
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.33743810
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22453773
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20841102
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20841102
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19679703
22IGF1R_20145208_ChIP-Seq_DFB_Human2.19424077
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17684100
24TAF15_26573619_Chip-Seq_HEK293_Human2.14359301
25CBX2_27304074_Chip-Seq_ESCs_Mouse2.13635364
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.12551840
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.06627022
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01671656
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95514114
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.94488912
31* RNF2_27304074_Chip-Seq_ESCs_Mouse1.91089163
32* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89317334
33AR_21572438_ChIP-Seq_LNCaP_Human1.88091854
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87502740
35VDR_22108803_ChIP-Seq_LS180_Human1.86298375
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81594702
37WDR5_24793694_ChIP-Seq_LNCAP_Human1.81166954
38P300_19829295_ChIP-Seq_ESCs_Human1.80853897
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79333877
40REST_21632747_ChIP-Seq_MESCs_Mouse1.77504304
41CTCF_27219007_Chip-Seq_Bcells_Human1.76511335
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70192471
43SMAD4_21799915_ChIP-Seq_A2780_Human1.69028763
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67488517
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65682227
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65139226
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.64988646
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61843344
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60998330
50SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.60412346
51RNF2_27304074_Chip-Seq_NSC_Mouse1.59562288
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58647384
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54450585
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.54153283
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.53855099
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.53039304
57DROSHA_22980978_ChIP-Seq_HELA_Human1.50844250
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49355926
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.49275689
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48620646
61SUZ12_18555785_Chip-Seq_ESCs_Mouse1.47320645
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43965545
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.43094783
64FUS_26573619_Chip-Seq_HEK293_Human1.42653329
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41713717
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41389403
67P53_22387025_ChIP-Seq_ESCs_Mouse1.41065218
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.40913294
69RARB_27405468_Chip-Seq_BRAIN_Mouse1.39317888
70ER_23166858_ChIP-Seq_MCF-7_Human1.38998165
71SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.38809346
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37226058
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.36219497
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35689788
75AR_25329375_ChIP-Seq_VCAP_Human1.34856600
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.34346574
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32973336
78SMAD3_21741376_ChIP-Seq_ESCs_Human1.32673162
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31634536
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.31213447
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30842299
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30303155
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29691550
84CBP_20019798_ChIP-Seq_JUKART_Human1.29691550
85STAT3_23295773_ChIP-Seq_U87_Human1.29666755
86GATA1_26923725_Chip-Seq_HPCs_Mouse1.29565727
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.29478946
88P300_18555785_Chip-Seq_ESCs_Mouse1.29330924
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.29135171
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.28793307
91BCAT_22108803_ChIP-Seq_LS180_Human1.28771559
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28189061
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28162357
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27869007
95EWS_26573619_Chip-Seq_HEK293_Human1.27498567
96E2F1_17053090_ChIP-ChIP_MCF-7_Human1.27438297
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25127685
98IRF1_19129219_ChIP-ChIP_H3396_Human1.24486037
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.22892296
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22779019
101ERA_21632823_ChIP-Seq_H3396_Human1.22588014
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21642871
103SMAD3_21741376_ChIP-Seq_HESCs_Human1.21264668
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20260993
105RAC3_21632823_ChIP-Seq_H3396_Human1.20219033
106SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20189352
107RUNX1_27457419_Chip-Seq_LIVER_Mouse1.20187826
108OCT4_20526341_ChIP-Seq_ESCs_Human1.18502058
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17889256
110SOX2_18555785_Chip-Seq_ESCs_Mouse1.17181344
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15972673
112MYC_19829295_ChIP-Seq_ESCs_Human1.15891467
113REST_18959480_ChIP-ChIP_MESCs_Mouse1.15291474
114ZFX_18555785_Chip-Seq_ESCs_Mouse1.14984937
115* RING1B_27294783_Chip-Seq_ESCs_Mouse1.14953376
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14853638
117KLF4_18555785_Chip-Seq_ESCs_Mouse1.14687869
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14217125
119TCF4_23295773_ChIP-Seq_U87_Human1.14096646
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13830668
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13497450
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13145424
123OCT4_18555785_Chip-Seq_ESCs_Mouse1.13133760
124TP53_18474530_ChIP-ChIP_U2OS_Human1.13129571
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12146865
126P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12112493
127ESRRB_18555785_Chip-Seq_ESCs_Mouse1.11897778
128THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11153830
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10797877
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10797877
131BCL6_27268052_Chip-Seq_Bcells_Human1.10513195
132SMAD4_21741376_ChIP-Seq_ESCs_Human1.10185492
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10075958
134NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09437598
135ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09425664
136PU1_27457419_Chip-Seq_LIVER_Mouse1.09131727
137PHF8_20622854_ChIP-Seq_HELA_Human1.08408964
138CTCF_18555785_Chip-Seq_ESCs_Mouse1.07670112
139TAL1_26923725_Chip-Seq_HPCs_Mouse1.07641013
140RUNX2_22187159_ChIP-Seq_PCA_Human1.06149388
141OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05340174
142TET1_21490601_ChIP-Seq_MESCs_Mouse1.03893020
143SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03208134
144P68_20966046_ChIP-Seq_HELA_Human1.02668692
145E2F1_20622854_ChIP-Seq_HELA_Human1.01952463
146EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00980001
147GATA3_21878914_ChIP-Seq_MCF-7_Human1.00158399
148SOX2_21211035_ChIP-Seq_LN229_Human0.97892021
149TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96223609
150HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95890362
151* SMC4_20622854_ChIP-Seq_HELA_Human0.94219967
152RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93920883
153ETV1_20927104_ChIP-Seq_GIST48_Human0.92764986
154KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92063506
155YY1_22570637_ChIP-Seq_MALME-3M_Human0.91597978
156* BCOR_27268052_Chip-Seq_Bcells_Human0.90768820
157FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90195515
158FOXA1_25329375_ChIP-Seq_VCAP_Human0.90195515
159EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89823933
160TAF2_19829295_ChIP-Seq_ESCs_Human0.88925263
161ETS1_20019798_ChIP-Seq_JURKAT_Human0.87419197
162NANOG_20526341_ChIP-Seq_ESCs_Human0.87255240
163MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86562780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.14451001
2MP0001529_abnormal_vocalization4.08764901
3MP0010386_abnormal_urinary_bladder3.31126089
4MP0003136_yellow_coat_color3.15172568
5MP0001188_hyperpigmentation3.03272704
6MP0001984_abnormal_olfaction3.01981680
7MP0005171_absent_coat_pigmentation2.83520698
8MP0001346_abnormal_lacrimal_gland2.81441370
9MP0003880_abnormal_central_pattern2.79748892
10MP0005551_abnormal_eye_electrophysiolog2.70656855
11MP0002735_abnormal_chemical_nociception2.65490520
12MP0005377_hearing/vestibular/ear_phenot2.62456313
13MP0003878_abnormal_ear_physiology2.62456313
14MP0000566_synostosis2.53845416
15MP0005410_abnormal_fertilization2.52176654
16MP0002102_abnormal_ear_morphology2.41374489
17MP0009046_muscle_twitch2.34701238
18MP0001968_abnormal_touch/_nociception2.30636456
19MP0002736_abnormal_nociception_after2.16800676
20MP0005083_abnormal_biliary_tract2.15451284
21MP0005248_abnormal_Harderian_gland2.12535582
22MP0001486_abnormal_startle_reflex2.12524456
23MP0002876_abnormal_thyroid_physiology2.08774160
24MP0006276_abnormal_autonomic_nervous2.07100913
25MP0005646_abnormal_pituitary_gland2.05355088
26MP0002638_abnormal_pupillary_reflex2.03030207
27MP0009745_abnormal_behavioral_response2.02035380
28MP0005167_abnormal_blood-brain_barrier1.93842065
29MP0003635_abnormal_synaptic_transmissio1.85965630
30MP0001986_abnormal_taste_sensitivity1.85330810
31MP0003122_maternal_imprinting1.83541781
32MP0002572_abnormal_emotion/affect_behav1.78697074
33MP0008877_abnormal_DNA_methylation1.76522107
34MP0000678_abnormal_parathyroid_gland1.75750409
35MP0002822_catalepsy1.75076862
36MP0001293_anophthalmia1.73334243
37MP0002272_abnormal_nervous_system1.72358470
38MP0001502_abnormal_circadian_rhythm1.70698428
39MP0002184_abnormal_innervation1.68411300
40MP0002063_abnormal_learning/memory/cond1.65859318
41MP0003698_abnormal_male_reproductive1.65142379
42MP0003879_abnormal_hair_cell1.64644317
43MP0002734_abnormal_mechanical_nocicepti1.64526162
44* MP0004742_abnormal_vestibular_system1.62926018
45* MP0002067_abnormal_sensory_capabilities1.62488148
46MP0006072_abnormal_retinal_apoptosis1.61886845
47MP0005645_abnormal_hypothalamus_physiol1.59705166
48MP0002277_abnormal_respiratory_mucosa1.59503405
49MP0002234_abnormal_pharynx_morphology1.58990858
50MP0002064_seizures1.58338585
51MP0004885_abnormal_endolymph1.54611068
52MP0005187_abnormal_penis_morphology1.54120128
53MP0003183_abnormal_peptide_metabolism1.54058125
54MP0004142_abnormal_muscle_tone1.52639775
55MP0005379_endocrine/exocrine_gland_phen1.52535359
56MP0002557_abnormal_social/conspecific_i1.50501541
57MP0005253_abnormal_eye_physiology1.48913499
58MP0003950_abnormal_plasma_membrane1.38464447
59MP0004957_abnormal_blastocyst_morpholog1.38176403
60MP0003787_abnormal_imprinting1.37937179
61MP0004859_abnormal_synaptic_plasticity1.36484565
62MP0001970_abnormal_pain_threshold1.36108251
63MP0003315_abnormal_perineum_morphology1.33920910
64MP0001929_abnormal_gametogenesis1.33525464
65MP0003942_abnormal_urinary_system1.31219783
66MP0003121_genomic_imprinting1.31042592
67MP0004133_heterotaxia1.30128386
68MP0002160_abnormal_reproductive_system1.29812790
69MP0004858_abnormal_nervous_system1.28632728
70MP0002796_impaired_skin_barrier1.25570446
71MP0000579_abnormal_nail_morphology1.25168353
72MP0000647_abnormal_sebaceous_gland1.23861941
73MP0004381_abnormal_hair_follicle1.23773427
74MP0005423_abnormal_somatic_nervous1.21257455
75MP0002751_abnormal_autonomic_nervous1.21192899
76MP0000015_abnormal_ear_pigmentation1.19373059
77* MP0001963_abnormal_hearing_physiology1.18784657
78MP0001340_abnormal_eyelid_morphology1.18668396
79MP0002909_abnormal_adrenal_gland1.18364148
80MP0003861_abnormal_nervous_system1.17454765
81MP0008260_abnormal_autophagy1.16261146
82* MP0000026_abnormal_inner_ear1.15534625
83MP0008058_abnormal_DNA_repair1.15518372
84MP0004782_abnormal_surfactant_physiolog1.14728957
85MP0005409_darkened_coat_color1.14586967
86MP0002938_white_spotting1.13601686
87MP0003868_abnormal_feces_composition1.12710559
88MP0002282_abnormal_trachea_morphology1.12450395
89MP0002210_abnormal_sex_determination1.11686792
90MP0002653_abnormal_ependyma_morphology1.11276761
91MP0004134_abnormal_chest_morphology1.10791348
92MP0009053_abnormal_anal_canal1.10323728
93MP0003137_abnormal_impulse_conducting1.09562123
94MP0009697_abnormal_copulation1.08629805
95MP0001440_abnormal_grooming_behavior1.08530086
96MP0003123_paternal_imprinting1.08406664
97* MP0002752_abnormal_somatic_nervous1.08306163
98MP0003011_delayed_dark_adaptation1.07635849
99MP0004811_abnormal_neuron_physiology1.07166008
100MP0000538_abnormal_urinary_bladder1.03694836
101MP0002152_abnormal_brain_morphology1.03422608
102MP0003119_abnormal_digestive_system1.02732799
103MP0000372_irregular_coat_pigmentation1.01829957
104MP0002733_abnormal_thermal_nociception1.01004521
105MP0002161_abnormal_fertility/fecundity1.00636506
106MP0000681_abnormal_thyroid_gland1.00534771
107MP0001501_abnormal_sleep_pattern0.99005289
108MP0000427_abnormal_hair_cycle0.97884691
109MP0004270_analgesia0.97384873
110MP0000534_abnormal_ureter_morphology0.97305615
111MP0000778_abnormal_nervous_system0.96382783
112MP0003941_abnormal_skin_development0.95912269
113MP0002254_reproductive_system_inflammat0.95705351
114* MP0002882_abnormal_neuron_morphology0.95524128
115MP0000631_abnormal_neuroendocrine_gland0.95447644
116MP0008789_abnormal_olfactory_epithelium0.93848635
117MP0001270_distended_abdomen0.93515892
118MP0008872_abnormal_physiological_respon0.92629281
119MP0001145_abnormal_male_reproductive0.91322928
120MP0005367_renal/urinary_system_phenotyp0.89945372
121MP0000516_abnormal_urinary_system0.89945372
122MP0001286_abnormal_eye_development0.89151619
123MP0002098_abnormal_vibrissa_morphology0.88449324
124MP0005386_behavior/neurological_phenoty0.87299556
125MP0004924_abnormal_behavior0.87299556
126MP0008770_decreased_survivor_rate0.85373394
127MP0005195_abnormal_posterior_eye0.85085048
128MP0008569_lethality_at_weaning0.85069039
129MP0005501_abnormal_skin_physiology0.84803444
130MP0008995_early_reproductive_senescence0.84016952
131MP0000762_abnormal_tongue_morphology0.83103516
132MP0005391_vision/eye_phenotype0.83004433
133MP0002090_abnormal_vision0.82648835
134MP0000955_abnormal_spinal_cord0.82318603
135MP0002081_perinatal_lethality0.81966944
136MP0005389_reproductive_system_phenotype0.80958685
137MP0008004_abnormal_stomach_pH0.79127533
138MP0005174_abnormal_tail_pigmentation0.78870996
139MP0005499_abnormal_olfactory_system0.77588844
140MP0005394_taste/olfaction_phenotype0.77588844
141MP0001664_abnormal_digestion0.76480623
142MP0000049_abnormal_middle_ear0.75885787
143MP0002095_abnormal_skin_pigmentation0.75783880
144* MP0002229_neurodegeneration0.74084297
145MP0005670_abnormal_white_adipose0.73554321
146MP0001324_abnormal_eye_pigmentation0.71670955
147MP0003718_maternal_effect0.70504877
148MP0001919_abnormal_reproductive_system0.69515321
149* MP0002066_abnormal_motor_capabilities/c0.69504235
150MP0002249_abnormal_larynx_morphology0.69417214
151* MP0001485_abnormal_pinna_reflex0.69245504
152MP0004145_abnormal_muscle_electrophysio0.69100417
153MP0000569_abnormal_digit_pigmentation0.67617795
154MP0003938_abnormal_ear_development0.66579886
155MP0003633_abnormal_nervous_system0.65467465

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.01510324
2Bilateral microphthalmos (HP:0007633)5.38049405
3Abnormality of the aortic arch (HP:0012303)4.24724948
4Febrile seizures (HP:0002373)4.10065992
5Aplasia/Hypoplasia of the sternum (HP:0006714)4.09347765
6Septo-optic dysplasia (HP:0100842)4.03270103
7Decreased central vision (HP:0007663)3.81625147
8Absent eyelashes (HP:0000561)3.79101181
9Abnormality of the pubic bones (HP:0003172)3.73359509
10Focal motor seizures (HP:0011153)3.68187749
11Absent eyebrow (HP:0002223)3.64280171
12Abnormal sex determination (HP:0012244)3.58903283
13Sex reversal (HP:0012245)3.58903283
14Volvulus (HP:0002580)3.46310002
15Morphological abnormality of the middle ear (HP:0008609)3.37586283
16Epileptic encephalopathy (HP:0200134)3.27178887
17Progressive cerebellar ataxia (HP:0002073)3.24089865
18Bifid tongue (HP:0010297)3.17597123
19Aplasia/Hypoplasia of the fovea (HP:0008060)3.13923581
20Hypoplasia of the fovea (HP:0007750)3.13923581
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.07100996
22True hermaphroditism (HP:0010459)3.05995296
23Abnormality of the labia minora (HP:0012880)3.03879400
24Increased corneal curvature (HP:0100692)3.00092307
25Keratoconus (HP:0000563)3.00092307
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.97940363
27Midline defect of the nose (HP:0004122)2.97579751
28Abnormal ciliary motility (HP:0012262)2.95470401
29Abnormal respiratory motile cilium physiology (HP:0012261)2.93025507
30Absent/shortened dynein arms (HP:0200106)2.87864919
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.87864919
32Facial cleft (HP:0002006)2.84884532
33Absence seizures (HP:0002121)2.83494931
34Bicornuate uterus (HP:0000813)2.74713169
35Dialeptic seizures (HP:0011146)2.71641336
36Optic nerve hypoplasia (HP:0000609)2.70303905
37Chronic hepatic failure (HP:0100626)2.70113192
38Anophthalmia (HP:0000528)2.67705274
39Renal hypoplasia (HP:0000089)2.66760914
40Abnormal biliary tract physiology (HP:0012439)2.65370412
41Bile duct proliferation (HP:0001408)2.65370412
42Sclerocornea (HP:0000647)2.64834311
43Cutaneous finger syndactyly (HP:0010554)2.64368964
44Abnormal respiratory epithelium morphology (HP:0012253)2.64287219
45Abnormal respiratory motile cilium morphology (HP:0005938)2.64287219
46Abnormality of the septum pellucidum (HP:0007375)2.63487447
47Abnormal lung lobation (HP:0002101)2.60964117
48Abnormality of the lacrimal duct (HP:0011481)2.58866193
49White forelock (HP:0002211)2.58822552
50Absent septum pellucidum (HP:0001331)2.58494870
51Papilledema (HP:0001085)2.51283485
52Reticulocytopenia (HP:0001896)2.49193103
53Vaginal atresia (HP:0000148)2.48804016
54Optic nerve coloboma (HP:0000588)2.48278243
55Abnormality of hair growth rate (HP:0011363)2.42990298
56Slow-growing hair (HP:0002217)2.42990298
57Genital tract atresia (HP:0001827)2.41752059
58Absent hair (HP:0002298)2.40368152
59Submucous cleft hard palate (HP:0000176)2.40151248
60Abnormality of DNA repair (HP:0003254)2.39270836
61Upper limb muscle weakness (HP:0003484)2.39202018
62Abnormality of the fovea (HP:0000493)2.39187266
63Pancreatic fibrosis (HP:0100732)2.38843441
64Myelomeningocele (HP:0002475)2.32636644
65Fetal akinesia sequence (HP:0001989)2.31335007
66Pendular nystagmus (HP:0012043)2.30733282
67Fragile nails (HP:0001808)2.29042225
68Patchy hypopigmentation of hair (HP:0011365)2.28748257
69Myokymia (HP:0002411)2.25899547
70Supernumerary spleens (HP:0009799)2.25605741
71Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.24882036
72Retinal dysplasia (HP:0007973)2.24471957
73Cupped ear (HP:0000378)2.20781388
74Abnormality of calcium-phosphate metabolism (HP:0100530)2.20207514
75Tubulointerstitial nephritis (HP:0001970)2.19981547
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.18768910
77Parakeratosis (HP:0001036)2.18538978
78Cutaneous syndactyly (HP:0012725)2.18189694
79Chromsome breakage (HP:0040012)2.17203288
80Unilateral renal agenesis (HP:0000122)2.15576573
81Atelectasis (HP:0100750)2.13591481
82Atonic seizures (HP:0010819)2.13274968
83Narrow nasal bridge (HP:0000446)2.12665344
84Generalized tonic-clonic seizures (HP:0002069)2.12079867
85Scrotal hypoplasia (HP:0000046)2.11584010
86Skull defect (HP:0001362)2.11036124
87Muscle fiber atrophy (HP:0100295)2.09920377
88Follicular hyperkeratosis (HP:0007502)2.09721900
89Duplicated collecting system (HP:0000081)2.08157496
90Choanal stenosis (HP:0000452)2.08108283
91Renal dysplasia (HP:0000110)2.06709090
92Severe visual impairment (HP:0001141)2.05996760
93Abnormality of the nasolacrimal system (HP:0000614)2.05981306
94Scanning speech (HP:0002168)2.05534893
95Aplasia/Hypoplasia of the macula (HP:0008059)2.03077981
96Abnormal rod and cone electroretinograms (HP:0008323)2.02128007
97Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.02070819
98Pheochromocytoma (HP:0002666)2.01962378
99Abnormality of alanine metabolism (HP:0010916)2.01675952
100Hyperalaninemia (HP:0003348)2.01675952
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01675952
102Abnormality of macular pigmentation (HP:0008002)2.00753976
103Conical tooth (HP:0000698)1.99284839
104Broad distal phalanx of finger (HP:0009836)1.99039356
105Sparse scalp hair (HP:0002209)1.97753871
106Abnormality of the clitoris (HP:0000056)1.97230978
107Rhinitis (HP:0012384)1.97225170
108Clitoromegaly (HP:0000057)1.96791932
109Bowel incontinence (HP:0002607)1.95690073
110Type 2 muscle fiber atrophy (HP:0003554)1.95574896
111Abnormality of nail color (HP:0100643)1.95166652
112Intellectual disability, moderate (HP:0002342)1.94127993
113Abnormality of lateral ventricle (HP:0030047)1.93763247
114Intestinal atresia (HP:0011100)1.93125021
115Male pseudohermaphroditism (HP:0000037)1.93054451
116Erythroderma (HP:0001019)1.91297404
117Focal seizures (HP:0007359)1.91065269
118Abnormality of the renal medulla (HP:0100957)1.89921436
119Pancreatic cysts (HP:0001737)1.89629324
120Oligodactyly (hands) (HP:0001180)1.89059958
121Turricephaly (HP:0000262)1.88674320
122Abnormality of the nasal septum (HP:0000419)1.88248001
123Hypothermia (HP:0002045)1.87884940
124Gaze-evoked nystagmus (HP:0000640)1.87677898
125Heterotopia (HP:0002282)1.86564622
126Abnormality of dental color (HP:0011073)1.86557572
127Ulnar claw (HP:0001178)1.85399229
128Aplasia/Hypoplasia of the tibia (HP:0005772)1.85245749
129Dysdiadochokinesis (HP:0002075)1.84030260
130Thickened helices (HP:0000391)1.83939034
131Menstrual irregularities (HP:0000858)1.83673983
132Recurrent corneal erosions (HP:0000495)1.83651132
133Absent speech (HP:0001344)1.83465627
134Osteomalacia (HP:0002749)1.83440211
135High anterior hairline (HP:0009890)1.83296247
136Abnormal large intestine physiology (HP:0012700)1.83167884
137Double outlet right ventricle (HP:0001719)1.82339240
138Congenital malformation of the right heart (HP:0011723)1.82339240
139Abnormal drinking behavior (HP:0030082)1.81493814
140Polydipsia (HP:0001959)1.81493814
141Short tibia (HP:0005736)1.80531204
142Congenital sensorineural hearing impairment (HP:0008527)1.80031206
143Protruding tongue (HP:0010808)1.79896281
144Abnormality of the heme biosynthetic pathway (HP:0010472)1.79142989
145Drooling (HP:0002307)1.79000995
146Clubbing of toes (HP:0100760)1.78911474
147Broad alveolar ridges (HP:0000187)1.78502119
148Increased IgM level (HP:0003496)1.77979578
149Keratitis (HP:0000491)1.77500973
150Long nose (HP:0003189)1.77011128
151Impulsivity (HP:0100710)1.76902056
152Maternal diabetes (HP:0009800)1.73606723
153Nephronophthisis (HP:0000090)1.73426706
154Bony spicule pigmentary retinopathy (HP:0007737)1.73322148
155Spastic tetraplegia (HP:0002510)1.73130522
156Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72157238
157Cellular immunodeficiency (HP:0005374)1.71882785
158Oral leukoplakia (HP:0002745)1.71484400
159Abnormality of incisor morphology (HP:0011063)1.70740969
160Blue irides (HP:0000635)1.70122469
161Median cleft lip (HP:0000161)1.69460400
162Amblyopia (HP:0000646)1.68922792
163Renal agenesis (HP:0000104)1.68406186
164Ependymoma (HP:0002888)1.67448810
165Abnormality of the intervertebral disk (HP:0005108)1.67243221
166Abnormal social behavior (HP:0012433)1.67225453
167Impaired social interactions (HP:0000735)1.67225453
168Gastrointestinal atresia (HP:0002589)1.66667875
169Pulmonary hypoplasia (HP:0002089)1.66522441
170Aplasia cutis congenita (HP:0001057)1.65712732
171Abnormality of the renal collecting system (HP:0004742)1.64966283
172Abnormal hair whorl (HP:0010721)1.63689035
173Aplasia/Hypoplasia affecting the retina (HP:0008061)1.62748331
174Abnormality of the renal cortex (HP:0011035)1.62669269
175Long foot (HP:0001833)1.62048189
176Redundant skin (HP:0001582)1.62008727
177Hyperthyroidism (HP:0000836)1.61404408
178Intellectual disability, progressive (HP:0006887)1.61389533
179Patellar aplasia (HP:0006443)1.61348123
180Neuroendocrine neoplasm (HP:0100634)1.60774844
181Abnormality of the labia (HP:0000058)1.60605340
182Aplasia/Hypoplasia of the patella (HP:0006498)1.60146861
183Abnormality of the ileum (HP:0001549)1.59507489

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK36.17075780
2CASK5.17449146
3INSRR4.66201618
4PBK4.40876861
5NEK23.66471882
6TNIK2.87829489
7MKNK22.82841915
8FRK2.79472068
9PRPF4B2.65847289
10IRAK22.55088365
11MAP2K72.35840217
12PLK42.20321304
13TNK22.07095447
14IRAK41.94793623
15STK38L1.93409231
16NTRK31.90963520
17PINK11.88016504
18PRKD21.73453140
19IRAK11.71906581
20MAPK131.70995077
21FES1.70221937
22PNCK1.68922370
23STK161.63118080
24PKN11.55099139
25NEK61.52620087
26BLK1.51134057
27YES11.46661422
28ADRBK21.46238408
29MAP4K21.42096960
30TXK1.38722229
31MARK11.36764095
32MKNK11.34969834
33BRAF1.29724337
34EPHA41.28586342
35FER1.25732982
36MAP3K41.22837003
37PRKCE1.20578853
38DYRK31.18235882
39SGK2231.17351488
40SGK4941.17351488
41STK41.14250541
42GRK71.14239203
43SGK21.12948067
44AKT31.12777784
45CDK31.07391982
46BMPR21.02861477
47MINK11.02634963
48SRPK11.01927364
49MST41.00786055
50TAOK20.98596562
51GRK10.98213848
52MAP3K140.96983820
53DYRK1A0.92215337
54NME10.91883050
55TYRO30.89523251
56IRAK30.89174431
57TRIM280.88504681
58EIF2AK20.87588665
59EPHA20.86832917
60EPHA30.85937805
61RPS6KA40.83710718
62CDK80.83650724
63SIK30.81753291
64MAP3K130.80044834
65VRK20.76584560
66CSNK1G30.76131454
67TLK10.75503470
68CAMK2D0.74634392
69PIK3CG0.73926618
70BUB10.72283860
71CSNK1A1L0.70785136
72PRKCG0.70322954
73CDK190.69935309
74CAMK2A0.69290371
75CAMK1G0.68046238
76MAP2K40.67458726
77CSNK1G20.66251034
78TSSK60.65052641
79LIMK10.62259546
80DAPK20.61703073
81MAP3K90.58729141
82GRK50.57827163
83CAMK10.57108466
84VRK10.56693907
85TRPM70.52684338
86UHMK10.51391759
87ADRBK10.51312408
88TAF10.49479252
89EPHB20.49437377
90WNK10.49182729
91CSNK1G10.48750110
92ERBB30.48346280
93PRKG10.46366911
94MAP3K120.46150169
95WEE10.45619553
96PRKACA0.45350898
97ZAK0.43996067
98NTRK10.43148603
99DYRK20.43038679
100RIPK40.42921306
101SGK30.42331629
102SIK20.42200663
103BMPR1B0.40823096
104CLK10.40142915
105BCR0.40142793
106BRD40.39881198
107CAMK40.39469488
108PHKG20.39370174
109PHKG10.39370174
110MAPK150.39279981
111TTK0.38780962
112MAP3K10.38738032
113AURKA0.38673820
114WNK40.38091313
115CAMKK20.38009847
116MUSK0.37911410
117ERBB20.36924059
118CSNK1D0.36503050
119DYRK1B0.35531353
120PLK20.34844231
121PRKD30.34633269
122PLK10.34147463
123CSNK1A10.33722988
124PRKG20.33475344
125CDK50.33059619
126TEC0.32651467
127EPHB10.32357155
128PRKAA10.32329901
129SGK10.32012716
130MARK20.31874049
131PRKCA0.31255469
132CAMK2B0.30742467
133TAOK30.30736064
134CDK10.30606936
135NTRK20.30475537
136PKN20.29633809
137MAP3K100.28455840
138BRSK10.28255814
139PIK3CA0.28153251
140CAMK1D0.28092897
141CAMK2G0.27890248
142STK380.27517766
143CDK20.27084042
144PRKAA20.26271667
145MAPK80.26252901
146BCKDK0.26092406
147PRKCZ0.25887402
148CSNK1E0.25742997
149RPS6KA50.25707563
150STK110.25640041
151RPS6KB10.25412082
152CHEK10.24072828
153CHEK20.24041507
154LATS20.22537208
155GSK3B0.22225321
156CDK70.21721869
157BMX0.21058952
158MAP3K60.19954815
159MAPK90.19714446
160NUAK10.19372564

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.14588529
2Morphine addiction_Homo sapiens_hsa050323.29168321
3Taste transduction_Homo sapiens_hsa047423.10786985
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.06765468
5GABAergic synapse_Homo sapiens_hsa047273.03720868
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.60169750
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.37291922
8Synaptic vesicle cycle_Homo sapiens_hsa047212.21463578
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.20756350
10Serotonergic synapse_Homo sapiens_hsa047262.18631930
11Oxidative phosphorylation_Homo sapiens_hsa001902.15163043
12Circadian entrainment_Homo sapiens_hsa047132.15123739
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.11951964
14Glutamatergic synapse_Homo sapiens_hsa047242.11434690
15Olfactory transduction_Homo sapiens_hsa047402.07146671
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.98967751
17Insulin secretion_Homo sapiens_hsa049111.88306301
18Huntingtons disease_Homo sapiens_hsa050161.73747744
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72939913
20Parkinsons disease_Homo sapiens_hsa050121.71717041
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69407353
22Non-homologous end-joining_Homo sapiens_hsa034501.67426866
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63620942
24Base excision repair_Homo sapiens_hsa034101.59995179
25Cholinergic synapse_Homo sapiens_hsa047251.55975960
26Sphingolipid metabolism_Homo sapiens_hsa006001.55697308
27Renin secretion_Homo sapiens_hsa049241.51052511
28Fatty acid metabolism_Homo sapiens_hsa012121.50966600
29Sulfur relay system_Homo sapiens_hsa041221.39513835
30Phototransduction_Homo sapiens_hsa047441.36644895
31Collecting duct acid secretion_Homo sapiens_hsa049661.35499445
32Salivary secretion_Homo sapiens_hsa049701.35298679
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34441830
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.29712549
35Butanoate metabolism_Homo sapiens_hsa006501.27904707
36Alzheimers disease_Homo sapiens_hsa050101.27622539
37RNA polymerase_Homo sapiens_hsa030201.27088851
38Calcium signaling pathway_Homo sapiens_hsa040201.24564400
39Circadian rhythm_Homo sapiens_hsa047101.23870160
40Rheumatoid arthritis_Homo sapiens_hsa053231.23110570
41RNA transport_Homo sapiens_hsa030131.18346011
42Selenocompound metabolism_Homo sapiens_hsa004501.16938955
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14108206
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.12590809
45Mismatch repair_Homo sapiens_hsa034301.09400109
46Type I diabetes mellitus_Homo sapiens_hsa049401.08153705
47Fatty acid elongation_Homo sapiens_hsa000621.08136392
48Dopaminergic synapse_Homo sapiens_hsa047281.07469601
49Basal cell carcinoma_Homo sapiens_hsa052171.06360321
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.05929939
51Type II diabetes mellitus_Homo sapiens_hsa049301.04132132
52Biosynthesis of amino acids_Homo sapiens_hsa012301.04073504
53Ether lipid metabolism_Homo sapiens_hsa005651.03924339
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03398950
55Pyruvate metabolism_Homo sapiens_hsa006201.02823515
56Hedgehog signaling pathway_Homo sapiens_hsa043401.01816208
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.00419311
58Ribosome_Homo sapiens_hsa030101.00132557
59Axon guidance_Homo sapiens_hsa043600.95847974
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95767863
61Basal transcription factors_Homo sapiens_hsa030220.92388830
62Arachidonic acid metabolism_Homo sapiens_hsa005900.91799532
63Graft-versus-host disease_Homo sapiens_hsa053320.90933442
64Long-term depression_Homo sapiens_hsa047300.90924157
65Fat digestion and absorption_Homo sapiens_hsa049750.87507101
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87472993
67Fatty acid biosynthesis_Homo sapiens_hsa000610.87255394
68Autoimmune thyroid disease_Homo sapiens_hsa053200.86915476
69Mineral absorption_Homo sapiens_hsa049780.86652529
70Pyrimidine metabolism_Homo sapiens_hsa002400.85424029
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85233121
72Nucleotide excision repair_Homo sapiens_hsa034200.83979381
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83242331
74Ovarian steroidogenesis_Homo sapiens_hsa049130.82940154
75Prion diseases_Homo sapiens_hsa050200.82600149
76Oxytocin signaling pathway_Homo sapiens_hsa049210.81859205
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79990839
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76359775
79Retinol metabolism_Homo sapiens_hsa008300.75655593
80African trypanosomiasis_Homo sapiens_hsa051430.75554855
81Amphetamine addiction_Homo sapiens_hsa050310.74884981
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73624043
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73323044
84Spliceosome_Homo sapiens_hsa030400.72472747
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72133852
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72050828
87Steroid biosynthesis_Homo sapiens_hsa001000.71262347
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71203324
89Melanoma_Homo sapiens_hsa052180.70801699
90Fanconi anemia pathway_Homo sapiens_hsa034600.70694421
91Arginine and proline metabolism_Homo sapiens_hsa003300.70296945
92Ras signaling pathway_Homo sapiens_hsa040140.69663074
93Metabolic pathways_Homo sapiens_hsa011000.68106437
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66776068
95Hippo signaling pathway_Homo sapiens_hsa043900.66385307
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65369851
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.65270126
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64002945
99Linoleic acid metabolism_Homo sapiens_hsa005910.63627051
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63557097
101Homologous recombination_Homo sapiens_hsa034400.63382231
102Histidine metabolism_Homo sapiens_hsa003400.61360702
103Alcoholism_Homo sapiens_hsa050340.59848747
104cAMP signaling pathway_Homo sapiens_hsa040240.59620625
105ABC transporters_Homo sapiens_hsa020100.58949120
106Lysine degradation_Homo sapiens_hsa003100.58749821
107Propanoate metabolism_Homo sapiens_hsa006400.58525631
108Choline metabolism in cancer_Homo sapiens_hsa052310.57477993
109Allograft rejection_Homo sapiens_hsa053300.56784085
110Fatty acid degradation_Homo sapiens_hsa000710.56777542
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54862968
112Cardiac muscle contraction_Homo sapiens_hsa042600.54264807
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53697464
114Purine metabolism_Homo sapiens_hsa002300.53640522
115Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53296846
116Other glycan degradation_Homo sapiens_hsa005110.52848201
117Vibrio cholerae infection_Homo sapiens_hsa051100.52505117
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51828493
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51524754
120ErbB signaling pathway_Homo sapiens_hsa040120.50964744
121Tight junction_Homo sapiens_hsa045300.50684628
122beta-Alanine metabolism_Homo sapiens_hsa004100.50018668
123Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49212406
124Long-term potentiation_Homo sapiens_hsa047200.48945052
125One carbon pool by folate_Homo sapiens_hsa006700.48662612
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.48098607
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47724209
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47617875
129Melanogenesis_Homo sapiens_hsa049160.45382267
130Phagosome_Homo sapiens_hsa041450.45009561
131GnRH signaling pathway_Homo sapiens_hsa049120.44676345
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44650238
133DNA replication_Homo sapiens_hsa030300.44313756
134Carbon metabolism_Homo sapiens_hsa012000.44248696
135Gastric acid secretion_Homo sapiens_hsa049710.44020253
136Pancreatic secretion_Homo sapiens_hsa049720.43712926
137Cyanoamino acid metabolism_Homo sapiens_hsa004600.43363060
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42866657
139Staphylococcus aureus infection_Homo sapiens_hsa051500.42204373
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.40598995
141mRNA surveillance pathway_Homo sapiens_hsa030150.39943895
142Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39934851
143Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39453893
144Dorso-ventral axis formation_Homo sapiens_hsa043200.39090495
145Vitamin digestion and absorption_Homo sapiens_hsa049770.39068966
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38650280
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.38040574
148Nitrogen metabolism_Homo sapiens_hsa009100.36805963
149Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36426116
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36359809
151MAPK signaling pathway_Homo sapiens_hsa040100.34866433
152Wnt signaling pathway_Homo sapiens_hsa043100.34161153
153Galactose metabolism_Homo sapiens_hsa000520.34079960
154Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33949430
155Cocaine addiction_Homo sapiens_hsa050300.33867529
156Dilated cardiomyopathy_Homo sapiens_hsa054140.32323455
157Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31231745
158NF-kappa B signaling pathway_Homo sapiens_hsa040640.30183803
159Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29878809

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